Ccne1

Summary

Gene Symbol: Ccne1
Description: cyclin E1
Alias: CYCLE, Ccne, G1/S-specific cyclin-E1, cyclin E
Species: rat

Top Publications

  1. ncbi Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors
    B A Schmidt
    Department of Urology, Heinrich Heine University of Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    Cancer Res 61:4214-21. 2001
  2. ncbi Different cell cycle regulation of vascular smooth muscle in genetic hypertension
    Felix C Tanner
    Cardiovascular Research, Physiology Institute, University Zurich Irchel, and the Division of Cardiology, University Hospital, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Hypertension 42:184-8. 2003
  3. ncbi Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism
    Jose L Mauriz
    Department of Physiology, University of Leon, and the Hospital of León, Spain
    Transl Res 149:46-53. 2007
  4. doi Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female ACI rats induced by estrogen
    S John Weroha
    Hormonal Oncogenesis Laboratory, University of Kansas Cancer Center, Kansas, KS 66160, USA
    Horm Cancer 1:34-43. 2010
  5. pmc Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control
    Peng Dong
    Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina 27708, USA
    Nat Commun 5:4750. 2014
  6. pmc Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia
    Niyathi H Shah
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
    J Neurosci 34:4326-31. 2014
  7. ncbi The Pezcoller lecture: cancer cell cycles revisited
    C J Sherr
    Howard Hughes Medical Institute and Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 60:3689-95. 2000
  8. doi ERK1/2 promotes cigarette smoke-induced rat pulmonary artery smooth muscle cells proliferation and pulmonary vascular remodeling via up-regulating cycline1 expression
    Mu Qing Yu
    Department of Respiratory Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 33:315-22. 2013
  9. pmc Drosophila Minus is required for cell proliferation and influences Cyclin E turnover
    Sébastien Szuplewski
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 23:1998-2003. 2009
  10. ncbi Mammalian cyclin-dependent kinases
    Marcos Malumbres
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    Trends Biochem Sci 30:630-41. 2005

Research Grants

Scientific Experts

Detail Information

Publications63

  1. ncbi Up-regulation of cyclin-dependent kinase 4/cyclin D2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors
    B A Schmidt
    Department of Urology, Heinrich Heine University of Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    Cancer Res 61:4214-21. 2001
    ..382; P = 0.00085). CDK2 and its catalytic partner cyclin E were down-regulated in 40% (19 of 47) and 42% (19 of 45) of the tumors, respectively, by a factor of 7 each...
  2. ncbi Different cell cycle regulation of vascular smooth muscle in genetic hypertension
    Felix C Tanner
    Cardiovascular Research, Physiology Institute, University Zurich Irchel, and the Division of Cardiology, University Hospital, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Hypertension 42:184-8. 2003
    ..Western blot analysis demonstrated that the level of cyclin D, cyclin E, and cyclin A was higher in SHR cells progressing through G1 phase, whereas expression of cyclin-dependent kinase ..
  3. ncbi Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism
    Jose L Mauriz
    Department of Physiology, University of Leon, and the Hospital of León, Spain
    Transl Res 149:46-53. 2007
    ..TNP-470 on cell proliferation and effectors of the apoptotic pathway, including p53, p21WAF1/CIP1, cyclin D, and cyclin E. Tumor was induced in male Wistar rats by diethylnitrosamine and promoted by two-thirds hepatectomy plus ..
  4. doi Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female ACI rats induced by estrogen
    S John Weroha
    Hormonal Oncogenesis Laboratory, University of Kansas Cancer Center, Kansas, KS 66160, USA
    Horm Cancer 1:34-43. 2010
    ..b>Cyclin E·CDK2 positive staining was confined to the large round cells found within focal dysplasias, ductal carcinomas in ..
  5. pmc Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control
    Peng Dong
    Computational Biology and Bioinformatics Program, Duke University, Durham, North Carolina 27708, USA
    Nat Commun 5:4750. 2014
    A body of evidence has shown that the control of E2F transcription factor activity is critical for determining cell cycle entry and cell proliferation...
  6. pmc Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia
    Niyathi H Shah
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
    J Neurosci 34:4326-31. 2014
    ..These results support a novel role for neuronal cyclin E1 in regulating the phosphorylation status and localization of Kv2.1 channels, a likely component of signaling cascades leading to ischemic preconditioning. ..
  7. ncbi The Pezcoller lecture: cancer cell cycles revisited
    C J Sherr
    Howard Hughes Medical Institute and Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 60:3689-95. 2000
    ..inhibitors of the Cip/Kip family, complementing the effects of the E2F transcriptional program by facilitating cyclin E-cdk2 activation at the G1-S transition...
  8. doi ERK1/2 promotes cigarette smoke-induced rat pulmonary artery smooth muscle cells proliferation and pulmonary vascular remodeling via up-regulating cycline1 expression
    Mu Qing Yu
    Department of Respiratory Medicine, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China
    J Huazhong Univ Sci Technolog Med Sci 33:315-22. 2013
    ..Our data demonstrated that increased expression of ERK1/2 and cyclinE1 might be involved in the pathogenesis of abnormal rPASMCs proliferation and rat pulmonary vascular remodelling induced by cigarette smoke exposure...
  9. pmc Drosophila Minus is required for cell proliferation and influences Cyclin E turnover
    Sébastien Szuplewski
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Genes Dev 23:1998-2003. 2009
    ..Here we present a novel cell cycle regulator, called minus, which influences Cyclin E turnover in Drosophila...
  10. ncbi Mammalian cyclin-dependent kinases
    Marcos Malumbres
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    Trends Biochem Sci 30:630-41. 2005
    ..of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function...
  11. pmc Overexpression of cyclin E/CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins
    Victoria Kolupaeva
    Department of Microbiology, New York University School of Medicine, NY, USA
    Cell Cycle 11:2557-66. 2012
    ..In cells overexpressing cyclin D1/CDK4, FGF-induced downregulation of cyclin E/CDK2 activity was absent...
  12. ncbi Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells
    Y Hosokawa
    Department of Biochemistry, Mie University Faculty of Medicine, Japan
    Biochem Mol Biol Int 37:393-9. 1995
    ..The present study demonstrates that the genes of cyclin E, cdk2, cdk5 and the transcriptional factor E2F-1 are expressed during the prolactin (PRL)-induced G1/S transition ..
  13. doi Up-regulation of cyclin-E(1) via proline-mTOR pathway is responsible for HGF-mediated G(1)/S progression in the primary culture of rat hepatocytes
    Kiyomasa Oka
    Division for Regenerative Drug Discovery, Center for Advanced Science and Innovation, Osaka University, Yamadaoka 2 1, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 435:120-5. 2013
    ..This is the first report to demonstrate the molecular bridge between amino acids and growth factors that drive mitogenic outcomes...
  14. ncbi Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2
    Chun Shik Park
    Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong dong, Puk Gu, Kwangju 500 712, Korea
    J Biol Chem 279:19592-9. 2004
    ..Here we demonstrate that cyclin-dependent kinase 2 (CDK2) in association with cyclin A or cyclin E directly binds to beta-catenin...
  15. ncbi Effects of cyclin D1 overexpression on G1 progression-related events
    M Imoto
    Columbia Presbyterian Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Exp Cell Res 236:173-80. 1997
    ..quiescent R6-ccnD1 cells had not only increased levels of the cyclin D1 protein but also increased levels of the cyclin E protein. The latter protein was complexed to phosphorylated cyclin-dependent kinase 2 (CDK2)...
  16. ncbi Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2
    T Aikawa
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 276:29347-52. 2001
    ..FGF2 increased p21 expression in RCS cells, which assembled with the cyclin E-Cdk2 complexes, although the expression of neither cyclin E nor Cdk2 increased...
  17. ncbi Integrated profiling of basal and luminal breast cancers
    José Adélaïde
    Marseille Cancer Research Center, Department of Molecular Oncology, Institut Paoli Calmettes and UMR599 Institut National de la Santé et de la Recherche Médicale, Marseille, France
    Cancer Res 67:11565-75. 2007
    ..Rare high-level amplifications contained BCL2L2, CCNE, EGFR, FGFR2, IGF1R, NOTCH2, and PIK3CA. Potential gene breaks involved ETV6 and FLT3...
  18. pmc The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities
    Anny Shai
    McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Cancer Res 67:1626-35. 2007
    ..tumors arising in E6 transgenic mice, we learned that E6 induces expression of the E2F-responsive genes, Mcm7 and cyclin E, in the absence of the E7 oncogene...
  19. ncbi HPV related VIN: highly proliferative and diminished responsiveness to extracellular signals
    Lindy A M Santegoets
    Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 121:759-66. 2007
    ..observed differences, we found that VIN appears to be a highly proliferative disease; many cyclins (CCNA, CCNB and CCNE) and almost all prereplication complex proteins are upregulated...
  20. ncbi Differential and combined effects of cardiotrophin-1 and TGF-beta1 on cardiac myofibroblast proliferation and contraction
    Vanja Drobic
    Institute of Cardiovascular Science, St Boniface General Hospital Research Centre, Department of Physiology, University of Manitoba, Winnipeg, MB, Canada
    Am J Physiol Heart Circ Physiol 293:H1053-64. 2007
    ..TGF-beta(1) treatment also increased expression of p27 and decreased expression of cyclin E and Cdk2 in primary cells...
  21. ncbi Cyclin E confers a prognostic value in premenopausal breast cancer patients with tumours exhibiting an infiltrative growth pattern
    P Berglund
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Malmo University Hospital, Malmo, Sweden
    J Clin Pathol 61:184-91. 2008
    To investigate the prognostic value of cyclin E in relation to tumour growth pattern by analysing stage II primary breast cancers from premenopausal women not subjected to any further adjuvant treatment...
  22. ncbi Progressive derailment of cell cycle regulators in endometrial carcinogenesis
    N Horree
    Department of Surgical Gynecology and Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Pathol 61:36-42. 2008
    Derailments of the control mechanisms of the cell cycle can initiate carcinogenesis, and play a role in progression to cancer.
  23. ncbi Impaired hepatic regeneration by ischemic preconditioning in a rat model of small-for-size liver transplantation
    AiHua Yao
    Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China
    Transpl Immunol 18:37-43. 2007
    ..This study was designed to evaluate the effects of IPC on liver regeneration in small-for-size liver grafts...
  24. ncbi Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma
    Ben Davidson
    Pathology Clinic, Radiumhospitalet Rikshospitalet Medical Center, Oslo, Norway
    Cancer 110:1264-71. 2007
    The authors recently reported on the role of cyclin E in differentiating ovarian/primary peritoneal carcinoma from malignant peritoneal mesothelioma using gene expression arrays...
  25. ncbi Di(2-ethylhexyl) phthalate induces apoptosis through peroxisome proliferators-activated receptor-gamma and ERK 1/2 activation in testis of Sprague-Dawley rats
    Ju Young Ryu
    College of Pharmacy, Pusan National University, Pusan, Republic of Korea
    J Toxicol Environ Health A 70:1296-303. 2007
    ..Results showed that the levels of pRB, cyclin D, CDK2, cyclin E, and CDK4 were significantly lower in rats given 500 and 750 mg/kg/d DEHP, while levels of p21 were significantly ..
  26. ncbi Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway
    Said Akli
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:7212-22. 2007
    In tumor cells, cyclin E deregulation results in the appearance of five low molecular weight (LMW) isoforms...
  27. ncbi Elevated cyclin E level in human clear cell renal cell carcinoma: possible causes and consequences
    Alicja Nauman
    Department of Biochemistry and Molecular Biology, Medical Center of Postgraduate Education, Warszawa, Poland
    Acta Biochim Pol 54:595-602. 2007
    The expression of cyclin E gene (CCNE) in relation to the expression of its major regulatory protein, E2F1, was examined in clear cell renal cell carcinomas (ccRCC)...
  28. ncbi Growth pattern switch of renal cells and expression of cell cycle related proteins at the early stage of diabetic nephropathy
    Yanling Zhang
    Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang 050051, China
    Biochem Biophys Res Commun 363:159-64. 2007
    ..b>Cyclin E, CDK(2) and P(27) were found significantly up-regulated in diabetic kidney...
  29. ncbi Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle
    Yong Ri Jin
    Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361 763, Korea
    J Cell Biochem 104:1-14. 2008
    ..inhibited not only phosphorylation of retinoblastoma protein (pRb) and expressions of cyclin A, cyclin D, cyclin E, cyclin-dependent kinase 2 (CDK2) as well as proliferating cell nuclear antigen (PCNA) protein, but also ..
  30. ncbi Association of cyclin D1 and E1 expression with disease progression and biomarkers in patients with nonmuscle-invasive urothelial cell carcinoma of the bladder
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9110, USA
    Urol Oncol 25:468-75. 2007
    ..To determine the association of cyclin D1 and E1 expression with bladder cancer presence, clinical and molecular characteristics, and disease progression in patients with nonmuscle-invasive urothelial cell carcinoma of the bladder...
  31. doi The expression of cyclins in neurons of rats after focal cerebral ischemia
    Bin Chen
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 28:60-4. 2008
    ..expression of Cyclin D1 and B1 in neurons was notably gradually down-regulated at 7th and 14th day, and that of Cyclin E and A was significantly up-regulated at 14th day after reperfusion as compared with that in control group (all P&..
  32. ncbi The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma
    Abeer A Bahnassy
    The Departments of Pathology, National Cancer Institute, Cairo, Egypt
    J Egypt Natl Canc Inst 18:292-302. 2006
    ..This is possibly achieved through an interaction between HPV oncogenic proteins and some cell cycle regulatory genes. However, the exact pathogenetic mechanisms are not well defined yet.
  33. doi Phospholipase C-delta1 expression is linked to proliferation, DNA synthesis, and cyclin E levels
    Jonathan D Stallings
    Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, Washington 98431, USA
    J Biol Chem 283:13992-4001. 2008
    ..The levels of cyclin E, a key regulator of the G1/S transition and DNA synthesis, were elevated in asynchronous cultures as well as ..
  34. doi Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation
    Il Je Cho
    Innovative Drug Research Center for Metabolic and Inflammatory Disease, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 151 742, Korea
    Arch Pharm Res 32:625-35. 2009
    ..The expression of cyclin E and the activity of cyclin E-dependent kinase were both enhanced by oltipraz treatment of PH rats...
  35. ncbi Inhibited activities in CCAAT/enhancer-binding protein, activating protein-1 and cyclins after hepatectomy in rats with thioacetamide-induced liver cirrhosis
    Gang Zhao
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 292:474-81. 2002
    ..AP)-1 and CCAAT/enhancer-binding protein (C/EBP) plays an important role in liver regeneration by modulating cell cycle regulators...
  36. doi The proliferative effect of synthetic N-POMC(1-28) peptides in rat adrenal cortex: a possible role for cyclin E
    Pedro O R de Mendonça
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 2415, Sao Paulo 05508 000, SP, Brazil
    Mol Cell Endocrinol 336:156-61. 2011
    ..In addition, we examine the cyclin E expression in rat adrenal cortex...
  37. ncbi Differential association of p21Cip1 and p27Kip1 with cyclin E-CDK2 during rat liver regeneration
    M J Pujol
    Department of Cell Biology, Faculty of Medicine, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, University of Barcelona, Spain
    J Hepatol 33:266-74. 2000
    ..The aim of this study was to examine the association of p21Cip1 and p27Kip1 with cyclin E-CDK2 and cyclin A-CDK2 complexes during rat liver regeneration and to correlate the association of both ..
  38. ncbi Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1
    K Tamura
    Department of Molecular Genetics, Osaka University, Japan
    Oncogene 8:2113-8. 1993
    ..Cig1, a B-type cyclin, of Schizosaccharomyces pombe, which has been suggested to act at the G1/S phase of the cell cycle. Cyclin G mRNA is induced within 3 h after growth stimulation and remains elevated with no apparent cell cycle ..
  39. ncbi Long-term 17alpha-ethinyl estradiol treatment decreases cyclin E and cdk2 expression, reduces cdk2 kinase activity and inhibits S phase entry in regenerating rat liver
    Lena Koroxenidou
    Department of Natural Science, Södertörns högskola University College, Box 4101, S 141 89 Huddinge, Sweden
    J Hepatol 43:478-84. 2005
    ..To identify the molecular targets of the mitoinhibitory effect of EE, the expression of proteins regulating G(1)- and S-progression were analyzed during the first cell cycle in EE-treated female Wistar rats.
  40. ncbi Overexpression of p21, cyclin E and decreased expression of p27 in DMBA (7, 12-dimethylbenzanthracene)-induced rat ovarian carcinogenesis
    Ki Kwon Kim
    Department of Pathology, Dongguk University College of Medicine, Kyongju, South Korea
    Pathol Int 53:291-6. 2003
    ..Inactivation of the tumor suppressor gene and deregulation of cyclin E are frequent in human ovarian cancer...
  41. ncbi [Changes in the activity of cyclin-kinase complexes governing cell transition from G1 phase to DNA replication phase in E1A + c-Ha-ras transformants transfected with the bcl-2 gene]
    A M Neliudova
    Institute of Cytology RAS, St Petersburg
    Tsitologiia 45:149-57. 2003
    ..Bcl-2 antiproliferative effect in E1A + c-Ha-ras-transformants was not associated with alterations in Cdk2, cyclin E and A contents...
  42. ncbi Mechanisms by which energy restriction inhibits rat mammary carcinogenesis: in vivo effects of corticosterone on cell cycle machinery in mammary carcinomas
    Zongjian Zhu
    Cancer Prevention Laboratory, Colorado State University, Fort Collins, 111 Shepardson, 1173 Campus Delivery, Fort Collins, CO 80523 1173, USA
    Carcinogenesis 24:1225-31. 2003
    ..Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, ..
  43. ncbi Molecular mechanism of progesterone-induced antiproliferation in rat aortic smooth muscle cells
    Wen Sen Lee
    Department of Physiology, School of Medicine, Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    Endocrinology 144:2785-90. 2003
    ..Western blotting analysis revealed that the protein levels of cyclin A, cyclin E, and cyclin-dependent-kinase (CDK) 2 but not cyclin D1 and CDK4 decreased after progesterone treatment, but those ..
  44. ncbi Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis
    K Hur
    Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, 441 744, Korea
    J Vet Sci 1:121-6. 2000
    ..dihydrochloride (DMH)-induced rat colon carcinogenesis, we studied the expression of cyclin D1 and cyclin E by quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis and immunohistochemistry (IHC)...
  45. ncbi Differential expression of cell cycle regulatory molecules and evidence for a "cyclin switch" during progression of prostate cancer
    Lisette A Maddison
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Prostate 58:335-44. 2004
    Deregulation of the cell cycle can be viewed as both cause and consequence of cancer...
  46. ncbi Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors
    Konstantin Christov
    Department of Surgical Oncology, University of Illinois, Chicago, IL, USA
    Breast Cancer Res Treat 77:253-64. 2003
    ..in proliferating (BrdU-labeled) cells, arrested the cells in G1/0 phase, and differentially decreased the cyclin E and cyclin D1 expression at mRNA and protein levels...
  47. ncbi A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry
    Yutaka Matsumoto
    Howard Hughes Medical Institute HHMI and Department of Pharmacology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Science 306:885-8. 2004
    Excess cyclin E-Cdk2 accelerates entry into S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells...
  48. ncbi Stimulation of a rat uterine stromal cell line in culture reveals a molecular switch for endocrine-dependent differentiation
    V Rider
    Department of Biology, Pittsburg State University, Pittsburg, Kansas 66762, USA
    J Endocrinol 184:119-27. 2005
    ..Comparison of cyclin E/Cdk2 activity between proliferating and differentiating cells showed a 3-fold increase (P< 0...
  49. ncbi D-type cyclins and G1 progression during liver development in the rat
    Joan M Boylan
    Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, RI 02903, USA
    Biochem Biophys Res Commun 330:722-30. 2005
    ..In fetal liver, Rb was highly phosphorylated at both cyclin D- and cyclin E-dependent sites...
  50. ncbi Nitrofurazone-induced gene expressions in rat hepatocytes and their modification by N-acetylcysteine
    Kyoko Ito
    Safety Research Laboratories, Yamanouchi Pharmaceutical Co, Ltd, 1 8 Azusawa 1 chome, Itabashi ku, Tokyo 174 8511, Japan
    Exp Toxicol Pathol 56:333-9. 2005
    ..followed by tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-alpha (TGF-alpha), c-Ha-ras, and cyclin E. The increases were blocked by concomitant administration of NAC...
  51. ncbi Effect of energy restriction on cell cycle machinery in 1-methyl-1-nitrosourea-induced mammary carcinomas in rats
    Weiqin Jiang
    Center for Nutrition in the Prevention of Disease, AMC Cancer Research Center, Denver, Colorado 80214, USA
    Cancer Res 63:1228-34. 2003
    ..01), and levels of cyclin E were reduced...
  52. pmc Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer
    Astrid M Eder
    Department of Molecular Therapeutics, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:12519-24. 2005
    ..model, overexpression of persistently active atypical PKC results in defects in apical-basal polarity, increased Cyclin E protein expression, and increased proliferation...
  53. ncbi The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein
    Christoph Geisen
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Virchowstrasse 173, D 45122 Essen, Germany
    J Biol Chem 277:39909-18. 2002
    We have previously shown that cyclin E can malignantly transform primary rat embryo fibroblasts in cooperation with constitutively active Ha-Ras...
  54. ncbi Dehydroepiandrosterone causes hyperplasia and impairs regeneration in rat liver
    Kathrin Kopplow
    Hormones and Signal Transduction, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Int J Oncol 27:1551-8. 2005
    ..after 3 days of treatment (100 mg/kg body weight per day) as indicated by significantly enhanced expression of cyclin E, PCNA and Ki-67 and an elevated number of mitotic figures...
  55. ncbi Vitamin E deficiency induces liver nuclear factor-kappaB DNA-binding activity and changes in related genes
    María Morante
    Universitat de Valencia, Departamentos de Bioquímica y Biología Molecular y Fisiología, Valencia, Spain
    Free Radic Res 39:1127-38. 2005
    ..and up-regulated transcription of gamma-glutamylcysteine synthetase (gamma-GCSM; gamma-GCSC), cyclin D1 and cyclin E. We also showed down-regulation of p21(Waf1/Cip1) transcription...
  56. pmc Parallel cyclin E and cyclin A expression in neoplastic lesions of the uterine cervix
    F Erlandsson
    Cancer Center Karolinska, CCK R8 04, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm 17176, Sweden
    Br J Cancer 94:1045-50. 2006
    b>Cyclin E levels are high during late G1 and early S-phase in normal cells. The cyclin E expression over the cell cycle in tumours is not fully known...
  57. ncbi Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization
    Puran S Bora
    Department of Ophthalmology and Visual Science, Kentucky Lions Eye Center, University of Louisville, KY, USA
    FEBS J 273:1403-14. 2006
    ..The increased accumulation of ethyl esters was associated with a 3.0-fold increased expression of cyclin E and cyclin E/CDK2; however, the level of the cyclin kinase inhibitor, p27Kip, did not change...
  58. ncbi Quantitative analysis of cyclin E and protein p34 cdc2 expression in superficial bladder cancer
    Piotr Kaczmarek
    Department of Pathophysiology and Clinical Immunology, Medical University of Lodz
    Pol J Pathol 57:41-4. 2006
    In the present study, the expression of cyclin E and kinase p34 cdc2 was investigated in preinvasive bladder tumors...
  59. ncbi [Effects of cyclin dependent protein kinase inhibitor olomoucine on the microenvironment of axonal regeneration after spinal cord injury: an experiment with rats]
    Dai Shi Tian
    Department of Neurology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan 430030, China
    Zhonghua Yi Xue Za Zhi 86:901-5. 2006
    ..To investigate the effects of olomoucine, a cyclin dependent protein kinase (CDK) inhibitor, on the microenvironment of axonal regeneration after spinal cord injury (SCI)...
  60. ncbi Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells
    Lucie Tosca
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 75:342-51. 2006
    Metformin is an anti-diabetic drug commonly used to treat cycle disorders and anovulation in women with polycystic ovary syndrome. However, the effects and molecular mechanism of metformin in the ovary are not entirely understood...
  61. ncbi Correlation of cyclin D1 and E1 expression with bladder cancer presence, invasion, progression, and metastasis
    Shahrokh F Shariat
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, TX 75390 9110, USA
    Hum Pathol 37:1568-76. 2006
    ..to determine the correlation of the expression of cyclin D1 and E1 with the expression of commonly altered cell cycle regulators and bladder cancer presence, staging, and clinical outcomes...
  62. pmc Methylmercury elicits rapid inhibition of cell proliferation in the developing brain and decreases cell cycle regulator, cyclin E
    Kelly Burke
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Neurotoxicology 27:970-81. 2006
    ..At 6h, MeHg decreased by 75% levels of cyclin E, a cell cycle regulator with roles in proliferation and apoptosis, without altering p57, p27, or CDK2 nor levels ..
  63. ncbi Granulosa cell expression of G1/S phase cyclins and cyclin-dependent kinases in PMSG-induced follicle growth
    Jennifer D Cannon
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Cell Endocrinol 264:6-15. 2007
    ..In addition, Cdk 2 protein increased transiently 12-24h after PMSG. Cyclin E expression increased significantly by 12h but remained elevated through 48 h, and multiple isoforms of Cyclin E ..

Research Grants2

  1. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..P27/Kip1 is a cell cycle suppressor that inhibits cyclin D1-D3/cdk4 and or cyclin E/cdk2 activity in the G1 phase of the cell cycle and thus prevents the G1-S transition and cell-type progression...
  2. Preventing choroidal neovascularization by long-term transscleral drug delivery
    PURAN BORA; Fiscal Year: 2006
    ..For proof-of-concept, we will use a novel, human protein-based therapy that has shown great potential in preliminary animal studies. [unreadable] [unreadable] [unreadable] [unreadable]..