Ccl2

Summary

Gene Symbol: Ccl2
Description: C-C motif chemokine ligand 2
Alias: MCP-1, Scya2, Sigje, C-C motif chemokine 2, chemokine (C-C motif) ligand 2, immediate-early serum-responsive JE protein, immediate-early serum-responsive protein JE, monocyte chemoattractant protein 1, monocyte chemotactic protein 1, small inducible cytokine A2, small inducible gene JE
Species: rat

Top Publications

  1. ncbi Albumin stimulates monocyte chemotactic protein-1 expression in rat embryonic mixed brain cells
    Charles Felix Calvo
    Chaire de Neuropharmacologie, INSERM U114, College de France, Paris, France
    J Neurosci Res 80:707-14. 2005
  2. doi Angiotensin II and tumor necrosis factor-alpha synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-kappaB, p38, and reactive oxygen species
    Masao Takahashi
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 294:H2879-88. 2008
  3. ncbi Association of serum MCP-1 concentration and MCP-1 polymorphism with insulin resistance in Japanese individuals with obese type 2 diabetes
    Kunichi Kouyama
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 53:345-54. 2008
  4. pmc Signal transduction of MCP-1 expression induced by pancreatitis-associated ascitic fluid in pancreatic acinar cells
    Laura Ramudo
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    J Cell Mol Med 13:1314-20. 2009
  5. pmc MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis
    T Narasaraju
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Kent Ridge 117597, Singapore
    Am J Respir Cell Mol Biol 42:732-43. 2010
  6. pmc CCL2/MCP-1 modulation of microglial activation and proliferation
    Ara E Hinojosa
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid, Avenida Complutense s n, Madrid, Spain
    J Neuroinflammation 8:77. 2011
  7. doi Curcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-κB pathways in rat vascular smooth muscle cells
    Yi Zhong
    Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People s Republic of China
    Inflamm Res 61:61-7. 2012
  8. pmc Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats
    Sushil K Jain
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Antioxid Redox Signal 11:241-9. 2009
  9. pmc Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals
    Malathesha Ganachari
    The Methodist Hospital Research Institute, The Methodist Hospital, Houston, Texas, United States of America
    PLoS ONE 5:e8881. 2010
  10. pmc MCP-1 promotes mural cell recruitment during angiogenesis in the aortic ring model
    Alfred C Aplin
    Department of Pathology, University of Washington, Seattle, WA, USA
    Angiogenesis 13:219-26. 2010

Detail Information

Publications178 found, 100 shown here

  1. ncbi Albumin stimulates monocyte chemotactic protein-1 expression in rat embryonic mixed brain cells
    Charles Felix Calvo
    Chaire de Neuropharmacologie, INSERM U114, College de France, Paris, France
    J Neurosci Res 80:707-14. 2005
    ..In the present study, we show that ovalbumin and albumin induce the release of monocyte chemotactic protein 1 (MCP-1/CCL2) from rat embryonic mixed brain cells...
  2. doi Angiotensin II and tumor necrosis factor-alpha synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-kappaB, p38, and reactive oxygen species
    Masao Takahashi
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 294:H2879-88. 2008
    ..These results also suggest that ANG II and TNF-alpha cooperatively stimulate vascular inflammation in vivo as well as in vitro...
  3. ncbi Association of serum MCP-1 concentration and MCP-1 polymorphism with insulin resistance in Japanese individuals with obese type 2 diabetes
    Kunichi Kouyama
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 53:345-54. 2008
    Monocyte chemoattractant protein-1 (MCP-1, also known as CCL2) secreted by adipocytes is a member of the CC chemokine family and plays a pivotal role in the inflammatory process...
  4. pmc Signal transduction of MCP-1 expression induced by pancreatitis-associated ascitic fluid in pancreatic acinar cells
    Laura Ramudo
    Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain
    J Cell Mol Med 13:1314-20. 2009
    ..In conclusion, acinar cells were activated by PAAF to produce MCP-1, mainly via NF-kappaB and STAT3 pathways. Both downstream pathways were targeted by Dx and NAC to repress the PAAF-mediated acinar MCP-1 up-regulation...
  5. pmc MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis
    T Narasaraju
    Infectious Diseases Program, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, 5 Science Drive 2, Kent Ridge 117597, Singapore
    Am J Respir Cell Mol Biol 42:732-43. 2010
    ....
  6. pmc CCL2/MCP-1 modulation of microglial activation and proliferation
    Ara E Hinojosa
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid, Avenida Complutense s n, Madrid, Spain
    J Neuroinflammation 8:77. 2011
    Monocyte chemoattractant protein (CCL2/MCP-1) is a chemokine that attracts cells involved in the immune/inflammatory response...
  7. doi Curcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-κB pathways in rat vascular smooth muscle cells
    Yi Zhong
    Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People s Republic of China
    Inflamm Res 61:61-7. 2012
    ....
  8. pmc Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats
    Sushil K Jain
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    Antioxid Redox Signal 11:241-9. 2009
    ..This suggests that curcumin supplementation can reduce glycemia and the risk of vascular inflammation in diabetes...
  9. pmc Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals
    Malathesha Ganachari
    The Methodist Hospital Research Institute, The Methodist Hospital, Houston, Texas, United States of America
    PLoS ONE 5:e8881. 2010
    ..MMP-1 may destabilize granuloma formation and promote tissue damage and disease progression early in the infection. Our findings may foster the development of new and personalized therapeutic approaches targeting MCP-1 and/or MMP-1...
  10. pmc MCP-1 promotes mural cell recruitment during angiogenesis in the aortic ring model
    Alfred C Aplin
    Department of Pathology, University of Washington, Seattle, WA, USA
    Angiogenesis 13:219-26. 2010
    ..These results implicate MCP-1 as one of the mediators of mural cell recruitment in the aortic ring model, and suggest that chemokine pathways may contribute to the assembly of the vessel wall during the angiogenesis response to injury...
  11. pmc Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP
    Craig W Younce
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Bldg 20, Rm 136, Orlando, FL 32816, USA
    Cardiovasc Res 87:665-74. 2010
    ..Here we report that high glucose-induced cardiomyocyte death is mediated via monocyte chemotactic protein-1 (MCP-1) production and induction of a novel zinc-finger protein...
  12. ncbi Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts
    Xin Li
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    J Biol Chem 282:33098-106. 2007
    ..This information provides a rationale for increased osteoclast activity in the anabolic effects of PTH in addition to receptor activator of NF-kappaB ligand stimulation to initiate greater bone remodeling...
  13. pmc HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production
    Markus Tölle
    Charite Campus Benjamin Franklin, Medizinische Klinik, Berlin, Germany
    Arterioscler Thromb Vasc Biol 28:1542-8. 2008
    ..Here we investigated the influence of HDL on MCP-1 production in vascular smooth muscle cells (VSMCs) and rat aortic explants...
  14. ncbi Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor
    Oksana Shynlova
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Immunol 181:1470-9. 2008
    ....
  15. doi The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat
    Jonathan K J Rhodes
    University of Edinburgh, Department of Anaesthesia, Critical Care and Pain Medicine, Western General Hospital, Edinburgh, Scotland
    J Neurotrauma 26:507-25. 2009
    ..macrophage inflammatory protein-2 (MIP-2/CXCL2) and the monocyte chemokine monocyte chemotactic protein-1 (MCP-1/CCL2) have been described in glial cells in vitro but their origin following TBI has not been established...
  16. doi Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm
    Masahiko Onoda
    Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Japan
    Atherosclerosis 208:366-9. 2010
    ..These findings suggest that LOX has a novel function in resolving inflammation by reducing MCP-1 in AAA...
  17. doi Expression of macrophage inflammatory protein-1α and monocyte chemoattractant protein-1 in glioma-infiltrating microglia: involvement of ATP and P2X₇ receptor
    Kuan Min Fang
    Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
    J Neurosci Res 89:199-211. 2011
    ....
  18. doi Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells
    Hidehisa Shimizu
    Department of Advanced Medicine for Uremia, Nagoya University Graduate School of Medicine, Japan
    Life Sci 90:525-30. 2012
    ..The present study examined whether indoxyl sulfate, a uremic toxin, regulates renal expression of MCP-1...
  19. doi Monocyte chemoattractant protein-1 (MCP-1) produced via NF-kappaB signaling pathway mediates migration of amoeboid microglia in the periventricular white matter in hypoxic neonatal rats
    Y Y Deng
    Department of Anatomy, Yong Loo Lin School of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore
    Glia 57:604-21. 2009
    ..It is concluded that the preponderance and active migration of AMC, as well as them being the main cellular source of MCP-1, may offer an explanation for the PWM being susceptible to hypoxic damage in neonatal brain...
  20. ncbi Lysophosphatidylcholine stimulates monocyte chemoattractant protein-1 gene expression in rat aortic smooth muscle cells
    James X Rong
    Department of Medicine and The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arterioscler Thromb Vasc Biol 22:1617-23. 2002
    ..We investigated whether lysophosphatidylcholine (LPC), enriched in oxidized low density lipoprotein, can modulate the expression of MCP-1 in arterial wall cells...
  21. ncbi The monocyte chemotactic protein-1 gene may contribute to hypertension in Dahl salt-sensitive rats
    Naomi Yasui
    Research Institute, National Cardiovascular Center, Japan
    Hypertens Res 30:185-93. 2007
    ..chain reaction (RT-PCR) and Northern blot analysis identified that, while the expression levels of Ccl2 mRNA were not different between the kidneys of DS and LEW rats fed a normal diet, those in DS were 10-fold higher ..
  22. ncbi The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1
    Jee Hoon Lee
    Department of Pharmacology, Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon, Korea
    J Immunol 181:8642-9. 2008
    ..Considering the importance of MCP-1 in inflammatory processes, our results suggest that 15d-PGJ(2) analogues may have therapeutic potential to attenuate inflammatory brain diseases by inducing MKP-1 expression...
  23. doi Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation
    Tomohiro Aoki
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Stroke 40:942-51. 2009
    ..Macrophages accumulate in CA walls and express proinflammatory genes promoting CA progression, but the molecular mechanisms of monocyte/macrophage recruitment into CA walls remain to be elucidated...
  24. pmc Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration
    Harihara S K Potula
    Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 284:31142-55. 2009
    ..These results show for the first time that 15-LOX1-15(S)-HETE axis plays a major role in vascular wall remodeling after balloon angioplasty...
  25. ncbi Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats
    Akiko Miyazaki
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Graefes Arch Clin Exp Ophthalmol 246:747-57. 2008
    ..The purpose of this study was to investigate the anti-inflammatory effect of a selective AT1 receptor antagonist, losartan, on endotoxin-induced uveitis (EIU) and compare the effect on experimental autoimmune uveoretinitis (EAU)...
  26. ncbi Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis
    O Gerdprasert
    Monash Institute of Reproduction and Development, Monash University, 27 31 Wright Street, Victoria, Australia
    Mol Hum Reprod 8:518-24. 2002
    ..Together with M-CSF, MCP-1 may also play a role in maintaining the resident macrophage population of the normal testis...
  27. pmc Increased expression of ICAM-1, VCAM-1, MCP-1, and MIP-1 alpha by spinal perivascular macrophages during experimental allergic encephalomyelitis in rats
    Nils Hofmann
    Institut für Anatomie der Universität zu Köln, Germany
    BMC Immunol 3:11. 2002
    ..Apart from the poor spatial and optical resolution, no differentiation between the resident SPM (mabs ED1+, ED2+) and the just recruited monocytes/macrophages (mab ED1+) was possible...
  28. doi Role of NAD(P)H oxidase in transforming growth factor-beta1-induced monocyte chemoattractant protein-1 and interleukin-6 expression in rat renal tubular epithelial cells
    Haiyan Zhang
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, China
    Nephrology (Carlton) 14:302-10. 2009
    ....
  29. doi Sequential evaluation of serum monocyte chemotactic protein 1 among asymptomatic state and acute exacerbation and remission of asthma in children
    Chin Kan Chan
    Graduate Institute of Clinical Medical Science, Chang Gung University, Taoyuan, Taiwan
    J Asthma 46:225-8. 2009
    b>Monocyte chemotactic protein 1 (MCP-1) plays an important role in various immune and allergic disorders since it is a potent chemo-attractant for inflammatory cells, such as eosinophils, memory T cells, and monocytes.
  30. doi Hypertonicity-induced expression of monocyte chemoattractant protein-1 through a novel cis-acting element and MAPK signaling pathways
    Ryoji Kojima
    Laboratory of Analytical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya 468 8503, Japan
    J Immunol 184:5253-62. 2010
    ..Furthermore, p38MAPK and MEK-ERK pathways appear to be, at least in part, involved in hypertonic stress-mediated regulation of MCP1 expression through the MCP1-TonE/ORE...
  31. doi Therapeutic effects of evasin-1, a chemokine binding protein, in bleomycin-induced pulmonary fibrosis
    Remo C Russo
    Laboratorio de Imunofarmacologia, Departamento de Bioquimica e Imunologia, Instituto de Ciências Biológicas Universidade Federal de Minas Gerais, Avenida Antonio Carlos, 6627, CEP 30882 650 Pampulha, Belo Horizonte, MG, Brazil
    Am J Respir Cell Mol Biol 45:72-80. 2011
    ..time after bleomycin challenge, and this was accompanied by increased number of leukocytes and elevated levels of CCL2/monocyte chemoattractant protein (MCP)-1, CCL5/regulated upon activation, normal T cell expressed and secreted, TNF-..
  32. doi Identification of genes and proteins specifically regulated by costimulation of mast cell Fcε Receptor I and chemokine receptor 1
    Cho Cho Aye
    Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Exp Mol Pathol 92:267-74. 2012
    ..Of the panel of chemokines and cytokines tested, only CCL2, CCL7 and interleukin (IL)-6 were expressed at higher levels following costimulation...
  33. doi Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions
    Nari Tei
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Toon, Ehime, Japan
    J Neurosci Res 91:681-93. 2013
    ..Thus, chemokines may play a critical role in the accumulation of neuroprotective BINCs. © 2013 Wiley Periodicals, Inc...
  34. ncbi [Effects of xiongshao capsule combined with ischemic postconditioning on monocyte chemoattractant protein-1 and tumor necrosis factor-alpha in rat myocardium with ischemic reperfusion injury]
    Da Wu Zhang
    Department of Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091
    Zhongguo Zhong Xi Yi Jie He Za Zhi 30:1279-83. 2010
    ....
  35. ncbi Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES
    Rujun Gong
    Division of Renal Diseases, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island 02903, USA
    J Am Soc Nephrol 15:2868-81. 2004
    ..These findings suggest that the beneficial effect of HGF in chronic renal disease is attributable, at least in part, to a direct anti-inflammatory action, likely via NF-kappaB, on tubular epithelial cells...
  36. ncbi Assessment of genetic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in Japanese
    Naoharu Iwai
    Department of Epidemiology, National Cardiovascular Center, Suita, Japan
    Circ J 70:805-9. 2006
    Recently, the Framingham Heart Study reported that genetic variations in CCL2 influence serum levels of monocyte chemoattractant protein-1 (MCP-1) and the incidence of myocardial infarction (MI)...
  37. pmc Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia
    Jie Chao
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Respir Cell Mol Biol 45:53-61. 2011
    ..Monocyte chemoattractant protein-1/Chemokine (C-C motif) ligand 2 (MCP-1/CCL2) is rapidly released by hypoxic alveolar macrophages...
  38. doi Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF
    Jasmeet Kaur
    Department of Biophysics, Panjab University, Chandigarh, India
    Mol Carcinog 50:707-18. 2011
    ..Our results indicate potential role of chemokines alongwith VEGF in angiogenesis in DMH-induced cancer and its chemoprevention with diclofenac...
  39. doi The endothelium-derived contracting factor uridine adenosine tetraphosphate induces P2Y(2)-mediated pro-inflammatory signaling by monocyte chemoattractant protein-1 formation
    Mirjam Schuchardt
    Charité Universitätsmedizin Berlin Med Klinik mit SP Nephrologie, Campus Benjamin Franklin, Berlin, Germany
    J Mol Med (Berl) 89:799-810. 2011
    ..This process requires the activation of the G-protein coupled receptor P2Y(2). Therefore, Up(4)A is not only a potent EDCF but also a potent inductor of pro-inflammatory response in the vascular wall...
  40. doi Regulation of CCL2/MCP-1 production in astrocytes by desipramine and atomoxetine: involvement of α2 adrenergic receptors
    Ara E Hinojosa
    Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense de Madrid and Centro de Investigación Biomédica en Red de Salud Mental, 28040 Madrid, Spain
    Brain Res Bull 86:326-33. 2011
    ..activation of β adrenergic receptors induces the synthesis of the chemokine monocyte chemoattractant protein (CCL2/MCP-1) in astrocytes, it is our interest to analyze the mechanisms involved in this process, particularly the ..
  41. ncbi Monocyte chemoattractant protein-1 (MCP-1/CCL2) in experimental autoimmune orchitis
    Vanesa A Guazzone
    Centro de Investigaciones en Reproduccion, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 piso 10, C1121 ABG, Buenos Aires, Argentina
    J Reprod Immunol 60:143-57. 2003
    ..The aim of this study was to detect the variations in the expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and its receptor in the testis of rats undergoing autoimmune orchitis...
  42. ncbi MCP-1 and MIP-2 expression and production in BB diabetic rat: effect of chronic hypoxia
    Cacchio Marisa
    Department of Biomedical Sciences, University G D Annunzio, Chieti, Italy
    Mol Cell Biochem 276:105-11. 2005
    ..1+/- 72). Our data point to MCP-1 and MIP-2 as important components in the pathophysiology of diabetes, and hypoxia is an important and potent environmental stimulus capable of modulating the expression and production of these chemokines...
  43. ncbi Apoptotic myocytes generate monocyte chemoattractant protein-1 and mediate macrophage recruitment
    Miyuki Kobara
    Dept of Clinical Pharmacology, Kyoto Pharmaceutical University, 5 Misasagi Nakauchi cho, Yamashina ku, Kyoto, Japan
    J Appl Physiol (1985) 104:601-9. 2008
    ..Concomitantly, activated macrophages infiltrated the areas of apoptosis remarkably. These results suggest that apoptotic myocytes produce MCP-1, which have a critical role in the active recruitment of macrophages...
  44. doi Participation of functionally different macrophage populations and monocyte chemoattractant protein-1 in early stages of thioacetamide-induced rat hepatic injury
    Yoko Mori
    Laboratories of Veterinary Pathology and Molecular Science, Life and Environmental Sciences, Osaka Prefecture University, Nakaku, Sakai, Osaka, Japan
    Toxicol Pathol 37:463-73. 2009
    ..Collectively, macrophages in acute hepatic necrosis may express different properties such as phagocytosis, MHC class II expression, and TGF-beta1 production; such expression may be influenced by MCP-1 produced by HSCs...
  45. doi Sustained activation of ERK signaling in astrocytes is critical for neuronal injury-induced monocyte chemoattractant protein-1 production in rat corticostriatal slice cultures
    Takahiro Katayama
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Eur J Neurosci 31:1359-67. 2010
    ..NMDA) treatment (50 microM, 3 h) induced astrocytic production of monocyte chemoattractant protein-1 (MCP-1, CCL2), a CC chemokine implicated in ischemic and excitotoxic brain injury, in rat corticostriatal slice cultures...
  46. doi 17beta-estradiol down-regulates lipopolysaccharide-induced MCP-1 production and cell migration in vascular smooth muscle cells
    Ping Jiang
    Department of Physiology, Zhongshan School of Medicine, Sun Yat Sen University, Guangdong, Guangzhou 510089, People s Republic of China
    J Mol Endocrinol 45:87-97. 2010
    ..study, we investigated the effect of estrogen on LPS-induced monocyte chemoattractant protein-1 (MCP-1; listed as CCL2 in the MGI database) production in vascular smooth muscle cells (VSMCs)...
  47. ncbi MCP-1/CCL2 protects cardiac myocytes from hypoxia-induced apoptosis by a G(alphai)-independent pathway
    Sima T Tarzami
    Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA
    Biochem Biophys Res Commun 335:1008-16. 2005
    ..In a previous study, we demonstrated that CCL2 protects cultured mouse neonatal cardiac myocytes from hypoxia-induced cell death...
  48. pmc Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors
    Xiao C Li
    Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA
    Am J Physiol Cell Physiol 294:C1034-45. 2008
    ....
  49. doi Rosiglitazone protects diabetic rats against kidney disease through the suppression of renal moncyte chemoattractant protein-1 expression
    Mao Zheng
    Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui Province of China
    J Diabetes Complications 23:124-9. 2009
    ..In conclusion, rosiglitazone may have a potential therapeutic target in DN, which may be partly attributed to lowering of the expression of MCP-1 in the local kidney and the urinary excretion of MCP-1...
  50. doi Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors
    Suresh N Magge
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 87:1547-55. 2009
    ..An understanding of NPC migration mechanisms may be used to enhance delivery of cytotoxic agents to brain tumor cells...
  51. ncbi [Effect of ginsenoside Rgl on the expression of TNF-alpha and MCP-1 in rats with diabetic nephropathy]
    Li Na Zhang
    Department of Nephrology, State Key Laboratory of Biotherapy of Human Disease, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:466-71. 2009
    ..To investigate the effects of Ginsenoside Rgl on proteinuria and the expression of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in rats with diabetic nephropathy (DN)...
  52. ncbi Myocardial expression of TNF-alpha, IL-1beta, IL-6, IL-8, IL-10 and MCP-1 after a single MDMA dose administered in a rat model
    Margherita Neri
    Department of Forensic Pathology, University of Foggia, Ospedale Colonnello D Avanzo, 71100 Foggia, Italy
    Curr Pharm Biotechnol 11:413-20. 2010
    ..The rise of the selective cardioinhibitory cytokines may be interpreted as the adaptive response of jeopardized myocardium to the cardiac dysfunction resulting from MDMA injection...
  53. ncbi Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria
    Hideaki Shimizu
    Division of Clinical Immunology, Department of Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Soc Nephrol 14:1496-505. 2003
    ..The fact that 7ND gene therapy had little effect on the contralateral kidney indicates that 7ND acted locally. This strategy may have a potential usefulness as a gene therapy against tubulointerstitial renal injury...
  54. ncbi Dexamethasone suppresses monocyte chemoattractant protein-1 production via mitogen activated protein kinase phosphatase-1 dependent inhibition of Jun N-terminal kinase and p38 mitogen-activated protein kinase in activated rat microglia
    Yan Zhou
    Department of Anatomy, Molecular Neurobiology Laboratory, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    J Neurochem 102:667-78. 2007
    ..This study reveals that the MKP-1 and MCP-1 as novel mediators of biological effects of Dex may help developing better therapeutic strategies for the treatment of patients with neuroinflammatory diseases...
  55. ncbi Ischemic cerebral tissue and MCP-1 enhance rat bone marrow stromal cell migration in interface culture
    Lei Wang
    Department of Neurology, Division of Hematology and Medical Oncology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Exp Hematol 30:831-6. 2002
    ..Adult MSCs administered intravenously to rat migrate and express neural phenotypes in ischemic brain. The aim of the present study was to investigate the mechanisms targeting MSC migration into the ischemic brain...
  56. ncbi MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation
    Madhav Bhatia
    Department of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool L69 3GA, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 282:G77-85. 2002
    ..This suggests that regulation of CC and CXC chemokines within acinar cells may be quite different...
  57. ncbi Levels of MCP-1 and GM-CSF mRNA correlated with inflammatory cytokines mRNA levels in experimental autoimmune myocarditis in rats
    Yoshiyuki Kobayashi
    First Department of Internal Medicine, Nara Medical University, Japan
    Autoimmunity 35:97-104. 2002
    ..These findings suggest that elevated MCP-1 and GM-CSF may associate with the migration and proliferation of monocytes/macrophages in EAM. Thus, MCP-1 and GM-CSF may play an important role in the progression of EAM...
  58. ncbi Muscle responds to an antibody reactive with the acetylcholine receptor by up-regulating monocyte chemoattractant protein 1: a chemokine with the potential to influence the severity and course of experimental myasthenia gravis
    Sara Reyes-Reyna
    Department of Microbiology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Immunol 169:1579-86. 2002
    ..e., monocyte chemoattractant protein 1) production by skeletal muscle cells...
  59. ncbi Constitutive patterns of RANTES, MCP-1 and MIP-1 alpha expression at the mRNA and protein level during postnatal development of the rat brain
    Anita M Geppert
    Division of Neuropathology, Department of Neurology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
    Folia Neuropathol 41:79-88. 2003
    ..This may support the differences between RANTES, MCP-1 and MIP-1alpha functional significance in vivo in terms of influence on the migration of distinct cell populations...
  60. ncbi Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells
    Lan Wu
    Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Onsen gun, Ehime 791 0295, Japan
    Mol Endocrinol 18:666-78. 2004
    ....
  61. ncbi Heat stress decreases pulmonary MCP-1 production in endotoxemia
    Jagadish Urs
    Children s Hospital of Michigan, Wayne State University, 3901 Beaubien, Detroit, MI 48201, USA
    Cytokine 26:243-6. 2004
    ..35 vs. 0.74+/-0.51, MCP-1/beta-actin mRNA, p <0.01). Control and heat alone rats had undetectable mRNA MCP-1 in the lungs. Heat stress prior to endotoxemia results in decreased production of MCP-1 by a post-transcriptional mechanism...
  62. ncbi Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration
    I Chung Lo
    Department of Cell Biology and Anatomy, National Cheng Kung University Medical College, Taiwan
    J Biomed Sci 12:377-88. 2005
    ....
  63. ncbi TGF-beta1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process
    Jingfei Cheng
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First St SW, Stabile 7, Rochester, Minnesota 55905, USA
    Am J Physiol Cell Physiol 289:C959-70. 2005
    ..Rp, by preventing TGF-beta1-stimulated MCP-1 production, may offer a therapeutic approach in retarding the progression of renal disease...
  64. pmc Blocking of monocyte chemoattractant protein-1 during tubulointerstitial nephritis resulted in delayed neutrophil clearance
    Ping Li
    Department of Medicine, Renal and Infectious Disease Sections, Baylor College of Medicine, Houston, TX 77030
    Am J Pathol 167:637-49. 2005
    ..Antagonism of MCP-1 in TIN by Ab or RA may alter the pathological process, most likely through delayed removal of apoptotic neutrophils in the inflammatory loci...
  65. ncbi The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
    Z Cermakova
    Immunology and Immunogenetics, Palacky University and Faculty Hospital Olomouc, Czech Republic
    Int J Immunogenet 32:315-8. 2005
    ..The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction...
  66. ncbi Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts
    Emma A Kruglov
    Section of Digestive Diseases and Yale Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 290:G765-71. 2006
    ..The cytokine monocyte chemoattractant protein-1 (MCP-1)/CCL2 is upregulated in biliary fibrosis by bile duct epithelia (BDE) and induces functional responses in HSC...
  67. ncbi HIV-infected patients with lipodystrophy have higher rates of carotid atherosclerosis: the role of monocyte chemoattractant protein-1
    Blai Coll
    Servei de Medicina Interna, Hospital Universitari Sant Joan, Reus, Spain
    Cytokine 34:51-5. 2006
    ..18, p=0.05). In summary, HIV-1-infected patients with clinically manifest LD are at higher risk for atherosclerosis and our observations support the relationship between inflammation and atherosclerotic disease...
  68. ncbi Expression of MCP-1 in the hippocampus of SHRSP with ischemia-related delayed neuronal death
    Yasuko Sakurai-Yamashita
    Department of Pharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852 8523, Japan
    Cell Mol Neurobiol 26:823-31. 2006
    ..As a result, such astrocytes expressing MCP-1 may therefore be related to the pathological events of delayed neuronal death in the pyramidal neurons...
  69. ncbi Increased expression of CCAAT/enhancer binding protein-beta and -delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats
    Y Sato
    Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga, 520 2192, Japan
    Diabetologia 50:481-9. 2007
    ..stimulates the expression of transcription factor CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP-delta and leads to the induction of the chemokine (C-C motif) ligand 2 gene (Ccl2, also known as MCP-1) expression in aortas.
  70. ncbi Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation
    Victoria Catalan
    Metabolic Research Laboratory, Clinica Universitaria de Navarra, University of Navarra, Pamplona, Spain
    Clin Endocrinol (Oxf) 68:213-9. 2008
    ....
  71. ncbi Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells
    S Giunti
    Department of Internal Medicine, University of Turin, C so AM Dogliotti, 14, 10126, Turin, Italy
    Diabetologia 51:198-207. 2008
    ....
  72. ncbi Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-kappaB activation
    Sun Young Hwang
    Department of Animal Science, University of Manitoba, Winnipeg, Canada
    Am J Physiol Renal Physiol 294:F236-44. 2008
    ..Our results suggest that hyperhomocysteinemia stimulates MCP-1 expression in the kidney via NF-kappaB activation. Such an inflammatory response may contribute to renal injury associated with hyperhomocysteinemia...
  73. ncbi Homocysteine induces monocyte chemoattractant protein-1 expression in hepatocytes mediated via activator protein-1 activation
    Connie W H Woo
    Departments of Animal Science and Physiology, University of Manitoba, Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, Canada
    J Biol Chem 283:1282-92. 2008
    ..These results suggest that Hcy-induced MCP-1 expression in the liver is mediated via AP-1 activation, which may contribute to chronic inflammation associated with hyperhomocysteinemia...
  74. doi The effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic rats
    Yang Lin
    Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China
    J Diabetes Complications 23:214-8. 2009
    ..This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats...
  75. pmc The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats
    A Schafer
    Department of Internal Medicine I Cardiology, University Hospital Wurzburg, Julius Maximilians University, Wurzburg, Germany
    Br J Pharmacol 154:1047-54. 2008
    ..We investigated the effect of rimonabant on inflammation and enhanced platelet reactivity in type 2 diabetic Zucker rats, an experimental model of impaired glucose tolerance and the metabolic syndrome...
  76. doi Nitric oxide and MCP-1 regulation in LPS activated rat Kupffer cells
    George Kolios
    Department of Gastroenterology, University of Crete, Greece
    Mol Cell Biochem 319:91-8. 2008
    ....
  77. ncbi Angiotensin-receptor blockade reduces border zone myocardial monocyte chemoattractant protein-1 expression and macrophage infiltration in post-infarction ventricular remodeling
    Takashi Kohno
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Circ J 72:1685-92. 2008
    ....
  78. doi Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain
    Sang Min Jeon
    Department of Anatomy, School of Medicine, Kyungpook National University, 2 101, Dongin Dong, Daegu, 700 422, South Korea
    Brain Res 1251:103-11. 2009
    ..Additionally, increased MCP-1 in both intact L4 and injured L5 DRG neurons may contribute to neuropathic pain hypersensitivity following L5 SNL...
  79. pmc Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease
    Judit Marsillach
    Centre de Recerca Biomedica, Hospital Universitari de Sant Joan, Institut d Investigacions Sanitaries Pere Virgili, Universitat Rovira i Virgili, C, Sant Joan s n, 43201 Reus, Spain
    BMC Gastroenterol 9:3. 2009
    ..We investigated the relationships between hepatic PON1 and MCP-1 expression in rats with liver disease and explored the possible molecular mechanisms involved...
  80. doi Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells
    Atsushi Ishikado
    Department of Medicine, Shiga University of Medical Science, Japan
    Atherosclerosis 205:404-12. 2009
    ..Moreover, we propose that SPC can be useful as a selective inhibitor to suppress the TLR4-mediated inflammatory signaling...
  81. pmc Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion
    Zongming Fu
    Laboratory of Cardiovascular Science, National Institute on Aging National Institutes of Health, Baltimore, MD 21224, USA
    Circ Res 104:1337-46. 2009
    ..Thus, targeting of MFG-E8 within this signaling axis pathway is a potential novel therapy for the prevention and treatment of the age-associated vascular diseases such as atherosclerosis...
  82. ncbi Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells
    M C Chen
    Gene Expression Unit, Diabetes Research Center, Vrije Universiteit Brussel, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Diabetologia 44:325-32. 2001
    ....
  83. ncbi Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Invest Dermatol 121:510-6. 2003
    ....
  84. ncbi Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas
    Michael Platten
    Laboratory of Molecular Neuro Oncology, Department of Neurology, University of Tubingen Medical School, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Ann Neurol 54:388-92. 2003
    ..This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth...
  85. ncbi An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
    Jayakrishna Ambati
    Department of Ophthalmology, University of Kentucky, 740 South Limestone Street, Lexington, Kentucky 40536 0284, USA
    Nat Med 9:1390-7. 2003
    ..Wild-type choroidal macrophages degrade C5 and IgG in eye sections of Ccl2(-/-) or Ccr2(-/-) mice...
  86. ncbi Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain
    Takahiro Tanaka
    Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Neurosci Res 48:463-9. 2004
    ..Furthermore, intrathecal administration of MCP-1 induced mechanical allodynia. These results suggest that MCP-1 produced in the DRG neurons is involved in the development of mechanical allodynia induced by nerve injury...
  87. ncbi Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis
    Marco Tucci
    University of Florida, and Malcom Randall VA Medical Center, Gainesville, 32610, USA
    Arthritis Rheum 50:1842-9. 2004
    ..In this study, we examined the role of a functional monocyte chemoattractant protein 1 (MCP-1) polymorphism in SLE and LN.
  88. ncbi Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons
    Ghazal Banisadr
    Institut National de la Santé et de la Recherche Médicale U732 Université Pierre et Marie Curie Hôpital Saint Antoine, Paris Cedex 12, France
    J Comp Neurol 492:178-92. 2005
    ..These data are largely in accordance with results obtained using quantitative autoradiography with [(125)I]MCP-1/CCL2 and RT-PCR CCR2 mRNA analysis...
  89. ncbi Cachexia--induced cerebellar degeneration: involvement of serum TNF and MCP-1 in the course of experimental neoplastic disease
    Sławomir Michalak
    Department of Neurochemistry and Neuropathology, Chair of Neurology, University of Medical Sciences, 49 Przybyszewskiego St 60 355 Poznań, Poland
    Acta Neurobiol Exp (Wars) 66:113-22. 2006
    ....
  90. ncbi Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus
    Nathan C Manley
    Department of Biological Sciences, Stanford University, Stanford, CA, USA
    Brain Res 1182:138-43. 2007
    ..To address this, we report the expression profile of the chemokine, monocyte chemoattractant protein-1 (MCP-1, CCL2), during kainate-induced seizure in the rat hippocampus...
  91. pmc Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus
    Ju Young Moon
    Department of Nephrology, College of Medicine, Kyunghee University, Seoul, Korea
    J Korean Med Sci 22:810-4. 2007
    ..Our result shows that the -2518 A allele of the MCP-1 gene is associated with kidney failure in Korean patients with type 2 DM...
  92. pmc Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors
    Sonia Bhangoo
    Cell Biology, Neurobiology and Anatomy, Loyola University Chicago, Maywood, IL, USA
    Mol Pain 3:38. 2007
    ....
  93. pmc Serum monocyte chemoattractant protein-1 concentrations associate with diabetes status but not arterial stiffness in children with type 1 diabetes
    Issam Zineh
    Department of Pharmacy Practice and Center for Pharmacogenomics, University of Florida College of Pharmacy, Gainesville, Florida, USA
    Diabetes Care 32:465-7. 2009
    ..We tested whether inflammatory monocyte chemoattractant protein (MCP)-1 concentrations correlate with arterial stiffness or type 1 diabetes status...
  94. doi Intraocular expression and release of high-mobility group box 1 protein in retinal detachment
    Noboru Arimura
    Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Lab Invest 89:278-89. 2009
    ..In addition, we assessed the vitreous concentrations of HMGB1 and monocyte chemoattractant protein 1 (MCP-1) in human eyes with RD...
  95. doi Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release
    A Guyon
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UNSA, UMR, 6097 CNRS, 660 route des Lucioles, Sophia Antipolis, 06560, Valbonne, France
    Neuroscience 162:1072-80. 2009
    ..Recently, we demonstrated that CCR2, the main receptor for the chemokine CCL2, is constitutively expressed in dopamine neurons in the rat substantia nigra...
  96. pmc Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma
    Kin Chiu
    Laboratory of Neurodegenerative Diseases, Department of Anatomy, University of Hong Kong, Pokfulam, Hong Kong, China
    Cell Mol Immunol 7:61-8. 2010
    Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a C-C chemokine involved in the activation and recruitment of monocytic cells to injury sites...
  97. doi Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration
    Jost B Jonas
    Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht Karls University, Heidelberg, Germany
    Arch Ophthalmol 128:1281-6. 2010
    To examine intraocular concentrations of monocyte chemoattractant protein 1 (MCP-1), soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular cell adhesion molecule 1 (sVCAM-1), and vascular endothelial growth factor (VEGF) ..
  98. pmc Chemokine CCL2 modulation of neuronal excitability and synaptic transmission in rat hippocampal slices
    Yan Zhou
    The Laboratory of Neurophysiology, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Neurochem 116:406-14. 2011
    In addition to its well-characterized effects in immune system, chemokine CC motif ligand 2 (CCL2, formerly known as monocyte chemoattractant protein-1) is believed to play an important role in brain physiological and pathological ..
  99. pmc Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells
    Martin A Kriegel
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 109:3457-62. 2012
    ..The exact role of the attracted cells is still poorly understood. Chemokine CCL2/MCP-1 is known to attract CCR2(+) monocytes and dendritic cells (DCs)...
  100. doi Upregulation of retinal neuronal MCP-1 in the rodent model of diabetic retinopathy and its function in vitro
    Ning Dong
    Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People s Republic of China
    Invest Ophthalmol Vis Sci 53:7567-75. 2012
    ..To evaluate the expression of monocyte chemoattractant protein-1 (MCP-1) in the rodent model of diabetic retinopathy (DR) and to study the stimulation of microglial activation by retinal neuronal MCP-1 in vitro...
  101. ncbi Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease
    M J Czaja
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461
    J Leukoc Biol 55:120-6. 1994
    ..To further define this process, the gene expression of the monocyte chemoattractant monocyte chemoattractant protein 1 (MCP-1) was examined in animal and human liver disease...

Research Grants8

  1. Surfactant protein variants in pediatric lung injury
    Neal Thomas; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  2. CHARACTERIZATION OF FRACTALKINE IN VITRO AND IN VIVO
    Lili Feng; Fiscal Year: 2003
    ....
  3. CELLULAR MECHANISM OF DIABETIC NEPHROPATHY
    Lili Feng; Fiscal Year: 2004
    ..Insights gained in the proposed studies will lead to the development of new therapeutic strategies to this life-threatening disease. ..
  4. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  5. Molecular Mechanism of Acupuncture
    Gabriela Garcia; Fiscal Year: 2006
    ..We believe that our studies may open new era towards molecular understanding of acupuncture treatment in pain, inflammation, as well as a variety of vascular diseases in humans. ..
  6. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  7. Chemokine receptor antagonists in inflammatory disease
    Shiva Shahrara; Fiscal Year: 2007
    ..Achieving these goals may give us valuable information in regard to molecular inflammatory mechanisms involved in atherosclerosis and RA. ..
  8. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..