caspase 3

Summary

Gene Symbol: caspase 3
Description: caspase 3
Alias: CPP32-beta, Lice, Yama, caspase-3, CASP-3, CPP-32, CPP32beta, Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease), IRP, SCA-1, SREBP cleavage activity 1, apopain, cysteine protease CPP32, cysteine protease p32-beta, protein Yama, yama protein
Species: rat

Top Publications

  1. ncbi Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 278:1248-58. 2003
  2. ncbi Erythropoietin preconditioning on hippocampus neuronal apoptosis following status epilepticus induced by Li-pilocarpine in rats through anti-caspase-3 expression
    XiaoNi Wen
    Department of Neurology, Xijing Hospital, The Fourth Military Medical University of Chinese PLA, China
    Neurol India 54:58-63; discussion 63. 2006
  3. doi Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland
    Antonio Mata
    Cidade Universitaria, Lisbon, Portugal
    Mol Cell Biochem 319:23-31. 2008
  4. ncbi [Temporal expression and significance of caspase-3 and interleukin-8 in the lungs of preterm rats exposed to hyperoxia]
    Wei Liu
    Department of Pediatrics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Er Ke Za Zhi 46:229-33. 2008
  5. doi Caspase-3-mediated cyclic stretch-induced myoblast apoptosis via a Fas/FasL-independent signaling pathway during myogenesis
    Jiaqiang Liu
    Department of Orthodontics, The Fourth Military Medical University, Xi an, Shanxi Province, People s Republic of China
    J Cell Biochem 107:834-44. 2009
  6. ncbi TRAIL signalling: decisions between life and death
    Christina Falschlehner
    Division of Apoptosis Regulation D040, Tumor Immunology Program, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Int J Biochem Cell Biol 39:1462-75. 2007
  7. ncbi Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3
    T S Juan
    Department of Developmental Hematology, Amgen, Inc, Thousand Oaks, California 91320, USA
    Oncogene 13:749-55. 1996
  8. ncbi 2-Methoxyestradiol enhances reactive oxygen species formation and increases the efficacy of oxygen radical generating tumor treatment
    C Lambert
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany
    Eur J Med Res 7:404-14. 2002
  9. ncbi Caspase-3 inhibits the growth of breast cancer cells independent of protease activity
    Beatrice Faraglia
    Istituto di Patologia Generale, Centro di Ricerche Oncologiche Giovanni XXIII, Rome, Italy
    J Cell Physiol 202:478-82. 2005
  10. ncbi In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures
    Tianfu Li
    Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, 200040 Shanghai, China
    Exp Neurol 197:301-8. 2006

Detail Information

Publications164 found, 100 shown here

  1. ncbi Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 278:1248-58. 2003
    ..CO, through p38 MAPK, indirectly modulates caspase 3. Furthermore, we correlate our in vitro apoptosis model with an in vivo model of A-R by showing that CO can ..
  2. ncbi Erythropoietin preconditioning on hippocampus neuronal apoptosis following status epilepticus induced by Li-pilocarpine in rats through anti-caspase-3 expression
    XiaoNi Wen
    Department of Neurology, Xijing Hospital, The Fourth Military Medical University of Chinese PLA, China
    Neurol India 54:58-63; discussion 63. 2006
    ..Recently, erythropoietin (Epo) has been shown to have potent anti-apoptosis activity in central nervous system neurons in animal models of ischaemic injury...
  3. doi Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland
    Antonio Mata
    Cidade Universitaria, Lisbon, Portugal
    Mol Cell Biochem 319:23-31. 2008
    ..This effect of H(2)O(2) may be due to its activity to induce apoptosis in the parotid gland, since H(2)O(2) can stimulate the activity of caspase-3, a marker of cellular apoptosis...
  4. ncbi [Temporal expression and significance of caspase-3 and interleukin-8 in the lungs of preterm rats exposed to hyperoxia]
    Wei Liu
    Department of Pediatrics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Er Ke Za Zhi 46:229-33. 2008
    ..To explore the temporal expression and significance of Caspase-3 and interleukin-8 (IL-8) in hyperoxia-induced lung injury in preterm rats...
  5. doi Caspase-3-mediated cyclic stretch-induced myoblast apoptosis via a Fas/FasL-independent signaling pathway during myogenesis
    Jiaqiang Liu
    Department of Orthodontics, The Fourth Military Medical University, Xi an, Shanxi Province, People s Republic of China
    J Cell Biochem 107:834-44. 2009
    ..Furthermore, we had provided evidence that caspase-3 mediated cyclic stretch-induced myoblast apoptosis. Mechanical forces induced activation of caspase-3 via signaling pathways independent of Fas/FasL system...
  6. ncbi TRAIL signalling: decisions between life and death
    Christina Falschlehner
    Division of Apoptosis Regulation D040, Tumor Immunology Program, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Int J Biochem Cell Biol 39:1462-75. 2007
    ..In this review we intend to summarise the most important findings on the TRAIL signalling network and the interplay in the decisions between life and death of a tumor cell...
  7. ncbi Molecular characterization of mouse and rat CPP32 beta gene encoding a cysteine protease resembling interleukin-1 beta converting enzyme and CED-3
    T S Juan
    Department of Developmental Hematology, Amgen, Inc, Thousand Oaks, California 91320, USA
    Oncogene 13:749-55. 1996
    ..Amino acid sequence analysis indicates that this rodent cysteine protease is the homolog of human CPP32 beta. Mouse CPP32 beta mRNA is highly expressed in spleen, and to a lesser degree in brain, lung, liver, and kidney...
  8. ncbi 2-Methoxyestradiol enhances reactive oxygen species formation and increases the efficacy of oxygen radical generating tumor treatment
    C Lambert
    Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany
    Eur J Med Res 7:404-14. 2002
    ..These results suggest that amplifying the levels of reactive oxygen species within tumor tissue with substances such as 2-ME may prove to be a promising strategy for adjuvant treatment of solid tumors...
  9. ncbi Caspase-3 inhibits the growth of breast cancer cells independent of protease activity
    Beatrice Faraglia
    Istituto di Patologia Generale, Centro di Ricerche Oncologiche Giovanni XXIII, Rome, Italy
    J Cell Physiol 202:478-82. 2005
    ..These results suggest that caspase-3 might have biological functions independent of its protease activity and that its loss might contribute to tumor development by increasing the growth potential of cancer cells...
  10. ncbi In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures
    Tianfu Li
    Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12 Wulumuqi Zhong Road, 200040 Shanghai, China
    Exp Neurol 197:301-8. 2006
    ..The significance of these findings in the treatment of epilepsy still needs to be extensively studied...
  11. ncbi Caspase function in programmed cell death
    S Kumar
    Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Cell Death Differ 14:32-43. 2007
    ..In this article, I will specifically focus on caspases that function primarily in cell death execution. In particular, the physiological function of caspases in apoptosis is discussed using examples from the worm, fly and mammals...
  12. ncbi Caspase-3 and Bcl-2 expression in aging in adrenal zona reticularis after dexamethasone administration
    Henrique Almeida
    Laboratory of Molecular Cell Biology, Faculdade de Medicina da Universidade do Porto, Alameda Hernani Monteiro, Porto, Portugal, PT 4200 319 Porto
    Ann N Y Acad Sci 1119:190-5. 2007
    ..The results confirm the involvement of Bcl-2 and caspase-3 proteins in the apoptotic pathway and suggest their simultaneous intervention...
  13. doi Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model
    James E Kendrick
    Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Gynecol Oncol 108:591-7. 2008
    ..To investigate the cytotoxicity of TRA-8, an antibody that specifically binds death receptor 5 (DR5), alone and in combination with cisplatin, using an ex vivo human cervical cancer model...
  14. doi Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease
    Young Mook Lee
    Department of Biology, 134 Shinchon dong, Seodaemoon Gu, Yonsei University College of Science, Seoul, Korea
    J Biol Chem 283:9986-98. 2008
    ....
  15. pmc Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents
    Michael F Wendland
    University California San Francisco, Department of Neurology, Box 0663, 521 Parnassus Ave, San Francisco, CA 94143 0663, USA
    Stroke 39:1862-8. 2008
    ..We asked whether the extent of injury depicted on DWI can predict the presence of caspase-3 activation, a quantitative marker of apoptotic injury, after hypoxia-ischemia (H-I) in postnatal day 7 rats...
  16. doi The effects of selenium against cerebral ischemia-reperfusion injury in rats
    Seda Ozbal
    Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, TR 35340, Izmir, Turkey
    Neurosci Lett 438:265-9. 2008
    ..The present results suggest that selenium is potentially a beneficial agent in treating IR-induced brain injury in rats...
  17. doi Death of hypothalamic astrocytes in poorly controlled diabetic rats is associated with nuclear translocation of apoptosis inducing factor
    C García-Cáceres
    Hospital Infantil Universitario Nino Jesus, Servicio de Endocrinologia, Madrid, Spain
    J Neuroendocrinol 20:1348-60. 2008
    ..However, enzymatic assays indicated that caspase 3 activity increased significantly after 1 week of diabetes and decreased below control levels thereafter...
  18. doi Amyloid oligomers in diabetic and nondiabetic human pancreas
    Hai Lu Zhao
    Department of Medicine and Therapeutics, Department of Anatomical and Cellular Pathology, Hong Kong Institute of Diabetes and Obesity, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
    Transl Res 153:24-32. 2009
    ..The observations warrant function studies to investigate the clinical implications of the amyloid oligomerization in the pathogenesis of type 2 diabetes...
  19. doi The effects of topiramate on caspase-3 expression in hippocampus of basolateral amygdala (BLA) electrical kindled epilepsy rat
    Xuqin Chen
    Department of Neurology, Children s Hospital of Soochow University, No 303, Jingde Road, Suzhou, 215003, China
    J Mol Neurosci 38:201-6. 2009
    ..These data suggest that topiramate may have a neuroprotective role in addition to its action as an anticonvulsant...
  20. doi Expression of caspase and apoptotic signal pathway induced by sulfur dioxide
    Juli Bai
    Institute of Environmental Medicine and Toxicology, Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006, China
    Environ Mol Mutagen 51:112-22. 2010
    ..These results suggest that SO(2) exposure increases the expression and activity of both initiator and and effector caspases, and may induce apoptosis in liver and lung of rats through both death receptor and mitochondrial pathways...
  21. pmc Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats
    Yong Zhang
    Department of Neurobiology, Institute of Biomedical Sciences, State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai 200032, People s Republic of China
    J Cereb Blood Flow Metab 30:566-75. 2010
    ..Our results provide new therapeutic targets to prevent further neurodegeneration in patients after stroke...
  22. doi Constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation in ghrelin protection against Porphyromonas gingivalis-induced salivary gland acinar cell apoptosis
    B L Slomiany
    Research Center, C875, UMDNJ NJ Dental School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103 2400, USA
    Inflammopharmacology 18:119-25. 2010
    ..The findings point to the involvement of ghrelin in Src/Akt kinase-mediated cNOS activation and the apoptogenic signal inhibition through the NO-induced caspase-3 S-nitrosylation...
  23. doi [Effect of formaldehyde on expressions of Fas apoptosis pathway-related genes of ovary tissues in female rats]
    Guoqing Peng
    Department of Toxicology, School of Public Health, Central South University, Changsha 410078, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:341-5. 2010
    ....
  24. pmc The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats
    Moon Sun Kim
    Department of Pediatrics, School of Medicine, Catholic University of Daegu, Daegu, Korea
    Korean J Pediatr 53:898-908. 2010
    ..Therefore, we investigated whether recombinant human EPO (rHuEPO) can protect against perinatal HI brain injury via an antiapoptotic mechanism...
  25. pmc Axonal outgrowth is associated with increased ERK 1/2 activation but decreased caspase 3 linked cell death in Schwann cells after immediate nerve repair in rats
    Yoshifumi Tsuda
    Department of Orthopedic Surgery, National Defense Medical College, Saitama, Japan
    BMC Neurosci 12:12. 2011
    ..In contrast, activation of caspase 3, a cysteine protease, is considered as a marker for apoptosis in Schwann cells...
  26. doi Phenotype of distinct primary sensory afferent subpopulations and caspase-3 expression following axotomy
    Adam J Reid
    Blond McIndoe Research Laboratories, Tissue Injury and Repair Group, University of Manchester, Oxford Road, Manchester, UK
    Histochem Cell Biol 136:71-8. 2011
    ..These findings provide further clarification in the understanding of two distinct neuronal populations used increasingly in nerve injury models...
  27. ncbi Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay
    Zhen hong Zhu
    Institute of Cardio cerebrovascular Disease, Zhejiang Chinese Medical University, Hangzhou, China
    Sheng Li Xue Bao 63:272-80. 2011
    ..These results suggest the absolute quantitative method established in the present study is capable of detecting the changes of IL-1β and Caspase-3 gene expressions in rat brain damaged by I/R...
  28. doi The VPAC2 agonist peptide histidine isoleucine (PHI) up-regulates glutamate transport in the corpus callosum of a rat model of amyotrophic lateral sclerosis (hSOD1G93A) by inhibiting caspase-3 mediated inactivation of GLT-1a
    Stephanie Goursaud
    Group of Neuropharmacology, Institute of Neuroscience, Universite Catholique de Louvain, 54 10, av Hippocrate 54, 1200 Brussels, Belgium
    FASEB J 25:3674-86. 2011
    ..Together, with evidence for a reduced expression of prepro-VIP/PHI mRNA in the corpus callosum of transgenic animals, these data shed light on the modulatory role of the VIP/PHI system on the glutamatergic transmission in ALS...
  29. doi Expression of activating transcription factor 3 (ATF 3) and caspase 3 in Schwann cells and axonal outgrowth after sciatic nerve repair in diabetic BB rats
    Lena Stenberg
    Hand Surgery Department of Clinical Sciences, Lund University, Skane University Hospital, SE 205 02 Malmo, Sweden
    Neurosci Lett 515:34-8. 2012
    ..in relation to the transcription factor, Activating Transcription Factor 3 (ATF 3), and an apoptotic marker, caspase 3, in the Schwann cells of diabetic BB rats (i.e. display type 1 diabetes phenotype)...
  30. doi The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide
    Gungor Kanbak
    Eskisehir Osmangazi University, The Medical School, Department of Biochemistry, Turkey
    Gene 512:492-5. 2013
    ..Protective effects of moderate ethanol consumption might be related to inhibition of lysosomal protease release and nitric oxide production...
  31. doi Transplantation of bone marrow-derived endothelial progenitor cells attenuates cerebral ischemia and reperfusion injury by inhibiting neuronal apoptosis, oxidative stress and nuclear factor-κB expression
    Jing Qiu
    Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, PR China
    Int J Mol Med 31:91-8. 2013
    ....
  32. pmc Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer
    Anupam Bishayee
    Department of Pharmaceutical Sciences, School of Pharmacy, American University of Health Sciences, Signal Hill, CA 90755, USA
    Int J Cancer 133:1054-63. 2013
    ..AMR-Me could be developed as a chemopreventive drug to reduce the risk of human breast cancer that remains a devastating disease. ..
  33. pmc Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model
    Bin Ma
    Department of Spine Surgery, Bone and Joint Medical Center, East Hospital, Tongji University School of Medicine, Shanghai, China
    PLoS ONE 8:e56580. 2013
    ..Whereas, the factors and the mechanism involved in the process of apoptosis induced by CEC remain unclear...
  34. doi Distinct functional brain regional integration of Casp3, Ascl1 and S100a6 gene expression in spatial memory
    Marina A Gruden
    P K Anokhin Institute of Normal Physiology RAMS, Moscow, Russia
    Behav Brain Res 252:230-8. 2013
    ....
  35. doi Pretreatment with sildenafil alleviates early lung ischemia-reperfusion injury in a rat model
    Pin Keng Shih
    Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan China Medical University, Taichung, Taiwan
    J Surg Res 185:e77-83. 2013
    ..Less well known is the role of sildenafil in lung I/R injury; therefore, we attempted to determine whether sildenafil could alleviate lung apoptosis and tissue injury in a rat model...
  36. doi Neonatal testosterone suppresses a neuroendocrine pulse generator required for reproduction
    Jean Marc Israel
    1 INSERM, U862, Neurocentre Magendie, F 33077 Bordeaux, France 2 Université de Bordeaux, F 33077 Bordeaux, France
    Nat Commun 5:3285. 2014
    ..This supports the view that stereotypic neuroendocrine pulsatility is governed by CPGs, some of which are subjected to gender-specific perinatal programming. ..
  37. doi Caspase-3 inhibition prevents the development of hepatopulmonary syndrome in common bile duct ligation rats by alleviating pulmonary injury
    Bing Chen
    Department of Anesthesia, Southwest Hospital, Third Military Medical University, Chongqing, China
    Liver Int 35:1373-82. 2015
    ..We assessed the effects of relieving pulmonary injury on Akt and ERK activation and on the development of HPS following CBDL...
  38. doi Curcumin ameliorate DENA-induced HCC via modulating TGF-β, AKT, and caspase-3 expression in experimental rat model
    Mekky M M Abouzied
    Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, El Madinah El Munawarah, P O Box 30001, Saudi Arabia
    Tumour Biol 36:1763-71. 2015
    ..It interferes and modulates cell signaling pathways and hence turns death signals and apoptosis on within tumor cells. ..
  39. doi Depletion of intracellular zinc induced apoptosis in cultured hippocampal neurons through Raf/MEK/ERK pathways
    Wei Pang
    Department of Nutrition, Institute of Hygiene and Environmental Medicine, Academy of Military Medical Science, Tianjin, China
    Nutr Neurosci 15:18-24. 2012
    ..It is possible that zinc depletion-induced apoptosis in cultured hippocampal neurons may be relevant to the changes of Raf/MEK/ERK signaling pathway...
  40. pmc Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation
    Ki Chun Yoo
    Laboratory of Molecular Biochemistry, Department of Chemistry, Hanyang University, Seoul, Republic of Korea
    Int J Nanomedicine 7:1203-14. 2012
    ..Recently, it has become evident that some TiO(2) particles have a considerable cytotoxic effect in normal human cells. However, the molecular basis for the cytotoxicity of TiO(2) has yet to be defined...
  41. doi Glutamine prevents apoptosis in intestinal epithelial cells and induces differential protective pathways in heat and oxidant injury models
    Alyssa R Kallweit
    Department of Anesthesiology, Translational PharmacoNutrition and Pharmacology Laboratory, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, USA
    JPEN J Parenter Enteral Nutr 36:551-5. 2012
    ..GLN's effect on HSPs in oxidant injury and apoptosis remains to be elucidated. The purpose of this study was to determine if GLN protects via decreasing apoptosis during both heat and oxidative stress...
  42. doi Kinetics of GADD45α, TP53 and CASP3 gene expression in the rat lens in vivo in response to exposure to double threshold dose of UV-B radiation
    Konstantin Galichanin
    St Erik s Eye Hospital, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Exp Eye Res 97:19-23. 2012
    ....
  43. doi Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats
    Zhong qian Lu
    The Intensive Care Unit, the First People s Hospital of Yancheng City, Yancheng 224005, PR China
    Mol Med Rep 6:371-4. 2012
    ..05). In conclusion, aloe polysaccharide has a protective effect on cerebral ischemia that may be due to the inhibition of neuronal cell apoptosis...
  44. doi Upregulation of cytochrome P450 2J3/11,12-epoxyeicosatrienoic acid inhibits apoptosis in neonatal rat cardiomyocytes by a caspase-dependent pathway
    Hong Xia Wang
    Department of Pathophysiology, Capital Medical University, Beijing 100069, China
    Cytokine 60:360-8. 2012
    ..Therefore, upregulation of CYP2J3/11,12-EET during HPost is involved in cardioprotection by inhibiting apoptosis via a caspase-dependent pathway, and the apoptosis-suppressive effect may have important clinical implications during HPost...
  45. ncbi [Effects of propofol on expression of hippocampal survivin and Caspase-3 in newborn rats]
    Xiao Man Tang
    Department of Anesthesiology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
    Zhonghua Er Ke Za Zhi 50:361-5. 2012
    ..We examined the effects of neonatal propofol exposure on brain cell viability, as well as expression of hippocampal survivin and Caspase-3 mRNA and protein...
  46. doi Immunoreactivity of Ki-67/β-tubulin and immunocolocalization with active caspase-3 in rat dentate gyrus during postnatal development
    Lirong Chang
    Department of Anatomy, Capital Medical University, Beijing, China
    J Chem Neuroanat 46:10-8. 2012
    ....
  47. doi Cleaved caspase-3 expression in hypothalamic magnocellular neurons may affect vasopressin secretion during experimental polymicrobial sepsis
    Gabriela Ravanelli Oliveira-Pelegrin
    Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    J Neuroimmunol 258:10-6. 2013
    ..Concomitantly, expression of the apoptosis effector, cleaved caspase 3, was increased in magnocellular neurons, inferring that this increase in hypothalamic neurons may be caused by ..
  48. ncbi Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle
    J A Flaws
    Department of Population Dynamics, Johns Hopkins University, Baltimore, Maryland 21205 2179, USA
    Endocrinology 136:5042-53. 1995
    ..Finally, we tested the requirement for IRP activity in granulosa cell apoptosis and follicular atresia by incubating follicles without and with IRP inhibitors...
  49. ncbi The membrane attack complex of complement induces caspase activation and apoptosis
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 32:783-92. 2002
    ..In line with this observation, complement induced cleavage and activation of caspase 3. Importantly, cellular exposure to purified cytolytically inactive C5b-9, in the absence of antibody and early ..
  50. pmc Cyclophilin-A is involved in excitotoxin-induced caspase activation in rat neuronal B50 cells
    Michela Capano
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 363:29-36. 2002
    ..It is concluded that neuroprotection by cyclosporin A against excitotoxin-induced apoptosis is, at least partly, due to inhibition of cyclophilin-A...
  51. ncbi Arachidonic acid converts the glutathione depletion-induced apoptosis to necrosis by promoting lipid peroxidation and reducing caspase-3 activity in rat glioma cells
    Yoshihiro Higuchi
    Department of Molecular Pharmacology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Arch Biochem Biophys 400:133-40. 2002
    ..Some ROS such as hydroperoxide produced by unknown pathway make hydroxy radicals and induce 8-OH-dG formation in the cells. The conversion of apoptosis to necrosis may be a possible event under GSH depleted conditions...
  52. ncbi Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain
    Ramanjit Gill
    F Hoffmann La Roche Ltd, Preclinical Research Basel, CNS Department, Basel, Switzerland
    J Cereb Blood Flow Metab 22:420-30. 2002
    ....
  53. pmc Caspase-3-dependent and -independent apoptosis in focal brain ischemia
    Vladimir V Didenko
    Department of Neurosurgery and Surgical Service, Baylor College of Medicine and VAMC, Houston, Texas 77030, USA
    Mol Med 8:347-52. 2002
    ..This raises the question whether caspase-3 synthesis and activation are essential for execution of the apoptotic program and DNA fragmentation in permanent brain ischemia, a condition that impairs cellular protein synthesis...
  54. pmc Caspase 3 activation is essential for neuroprotection in preconditioning
    BethAnn McLaughlin
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 100:715-20. 2003
    ..In an in vivo model of ischemic tolerance, we were surprised to observe widespread caspase 3 cleavage, without cell death, in preconditioned tissue...
  55. ncbi Caspase-3 and -6 expression and activation are targeted by hormone action in the rat ventral prostate during the apoptotic cell death process
    Asma Omezzine
    Institut National de la Santé et de la Recherche Médicale INSERM U 407, Faculté de médecine Lyon Sud, 69921, Oullins, France
    Biol Reprod 69:752-60. 2003
    ....
  56. ncbi Caspase-3-dependent reactivation of latent herpes simplex virus type 1 in sensory neuronal cultures
    Elizabeth A Hunsperger
    Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
    J Neurovirol 9:390-8. 2003
    ..Interestingly, the caspase-3 inhibitor had no effect on productive HSV-1 infection. Furthermore, activation of caspase-3 with either C2-ceramide or a recombinant adenovirus expressing caspase-3 caused significant HSV-1 reactivation...
  57. ncbi Caspase activity is essential for long-term potentiation
    Natalia V Gulyaeva
    Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
    J Neurosci Res 73:853-64. 2003
    ..Candidate caspase-3 substrates that may be cleaved for LTP induction and maintenance are discussed...
  58. ncbi Endurance exercise training inhibits activity of plasma GOT and liver caspase-3 of mice [correction of rats] exposed to stress by induction of heat shock protein 70
    Toshio Mikami
    Department of Health and Sports Science, Nippon Medical School, 2 297 2 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa 211 0063, Japan
    J Appl Physiol (1985) 96:1776-81. 2004
    ..These results suggest that exercise training enhanced the resting level of liver HSP70 and hepatic protection against various stresses, at least partly attributing to the suppression of caspase-3 activity by the increase in HSP70...
  59. pmc Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells
    Florian Guthmann
    Humboldt Universitat zu Berlin, Klinik für Neonatologie, Charite Campus Mitte, D 10098 Berlin, Germany
    Respir Res 6:10. 2005
    ..We hypothesised that, in the initial phase of hyperoxia, TNFalpha activates the caspase cascade in type II pneumocytes (TIIcells)...
  60. ncbi The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats
    Anders A F Sima
    Wayne State University School of Medicine, Department of Pathology, 540 E Canfield Ave, Detroit, MI 48201, USA
    Diabetes 54:1497-505. 2005
    ..These findings were associated with the prevention of increased expression of Bax and active caspase 3 and the frequency of caspase 3-positive neurons...
  61. ncbi PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone
    Gang Wang
    Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    FEBS Lett 579:4005-11. 2005
    ....
  62. ncbi Inflammation and caspase activation in long-term renal ischemia/reperfusion injury and immunosuppression in rats
    Bin Yang
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, UK
    Kidney Int 68:2050-67. 2005
    ..For the first time, we have now investigated the effects of I/R and immunosuppression on inflammation and caspase activation...
  63. pmc Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis
    Ming Cheng Liu
    Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, McKnight Brain Institute, University of Florida, P O Box 100256, Gainesville, FL 32610, USA
    Biochem J 394:715-25. 2006
    ..In summary, we demonstrated that HTPI is a novel and powerful method for studying proteolytic pathways in vivo and in vitro...
  64. ncbi Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity
    David C Zebrowski
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, 07103, USA
    J Mol Cell Cardiol 40:605-18. 2006
    ....
  65. ncbi Proliferation related acidic leucine-rich protein PAL31 functions as a caspase-3 inhibitor
    Weiyong Sun
    Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 342:817-23. 2006
    ..In conclusion, PAL31 is a multifunctional protein working as a cell cycle progression factor as well as a cell survival factor...
  66. ncbi ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
    J Biol Chem 281:20315-25. 2006
    ....
  67. ncbi Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1
    Julie D Atkin
    Brain Injury and Repair Group, Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, USA
    J Biol Chem 281:30152-65. 2006
    ..The possibility that PDI may be a therapeutic target to prevent SOD1 aggregation is also raised by this study...
  68. ncbi The role of caspase-3 activation in phencyclidine-induced neuronal death in postnatal rats
    Cheng Z Wang
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555 1031, USA
    Neuropsychopharmacology 32:1178-94. 2007
    ..These data demonstrate that caspase-3 activation plays a necessary role in the regionally selective neuronal death induced by PCP in the developing rat brain...
  69. ncbi Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia
    Michael van Hoecke
    Laboratoire de Pharmacodynamie et Physiologie Pharmaceutique, Faculte de Pharmacie, 7 Boulevard Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Mol Cell Neurosci 34:40-7. 2007
    ..Altogether the present data provide strong arguments for a causative relationship between HIF-1alpha and caspase-3 inductions through a functional binding activity to the caspase-3 gene promoter...
  70. ncbi Inhibition of HtrA2/Omi ameliorates heart dysfunction following ischemia/reperfusion injury in rat heart in vivo
    Md Shenuarin Bhuiyan
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Eur J Pharmacol 557:168-77. 2007
    ..These results suggest that UCF-101 rescues cardiomyocytes from ischemia/reperfusion injury by inhibiting XIAP degradation and Fas/Fas-ligand-induced apoptosis, thereby ameliorating ischemia/reperfusion-induced myocardial dysfunction...
  71. ncbi Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis
    Keren Yacobi
    Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel
    Endocrinology 148:1717-26. 2007
    ..Thus, this study reveals a linkage between two seemingly distinct processes in which LH-induced caspase activation in cultured rat preovulatory follicles is coupled to mitochondrial steroidogenesis via P450scc...
  72. ncbi Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Lancet Oncol 8:128-36. 2007
    ....
  73. ncbi Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation
    Makio Saeki
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:11786-94. 2007
    ..These results suggest that calcineurin B potentiates the activation of procaspase-3 by accelerating its proteolytic maturation...
  74. ncbi [Protective effects of minocycline against apoptosis of olfactory sensory neurons]
    Fanglei Ye
    Department of Otorhinolaryngology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 20:1135-7. 2006
    ..To investigate the protective effects of minocycline against apoptosis of olfactory sensory neurons induced by sinusitis...
  75. ncbi VX-induced cell death involves activation of caspase-3 in cultured rat cortical neurons
    Catherine C Tenn
    Medical Therapy Group, DRDC Suffield, P O Box 4000, Station Main, Medicine Hat, Alberta T1A 8K6, Canada
    Neurosci Lett 417:155-9. 2007
    ..These data suggested that in rat cortical neurons, VX-induced cell death via a programmed cell death pathway that involves changes in caspase-3 protease...
  76. ncbi Anti-tumor effect of endostatin mediated by retroviral gene transfer in mice bearing renal cell carcinoma
    Enia Lúcia Coutinho
    Division of Nephrology, Department of Medicine, Universidade Federal de Sao Paulo, SP, Brazil
    FASEB J 21:3153-61. 2007
    ..A second mechanism may also be implied in endostatin-dependent tumor regression, associated with tumor infiltration of leukocytes. Besides its antiangiogenic properties, endostatin may be a promising adjuvant to immunotherapy...
  77. ncbi Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression
    Carmine Morisco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Napoli, Italy
    Cardiovasc Res 76:453-64. 2007
    ..Caspases are a family of cysteine proteases that regulate apoptosis. We explored the effects of insulin resistance on hypoxia-induced caspase-3 activation in cardiomyocytes...
  78. ncbi The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells
    Ki Won Kim
    Department of Orthopedic Surgery, St Mary s Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea
    Spine (Phila Pa 1976) 32:2443-8. 2007
    ..Western blotting and flow cytometric analyses were performed using rat notochordal cells...
  79. doi Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat
    Erik Vahtola
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Hypertens 26:334-44. 2008
    ....
  80. pmc 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action
    W Wang
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham AL 35294, USA
    Br J Cancer 98:792-802. 2008
    ..In conclusion, our preclinical data indicate that 25-OCH3-PPD is a potential therapeutic agent against both androgen-dependent and androgen-independent prostate cancer...
  81. doi A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells
    Morgane Gorria
    INSERM U620, Toxicity of polycyclic aromatic hydrocarbons group Equipe Labellisée Ligue contre le Cancer, Faculte de Pharmacie, Universite Rennes I, 2 Avenue Pr Léon Bernard, Rennes Cedex, France
    Toxicol Appl Pharmacol 228:212-24. 2008
    ....
  82. doi Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis
    Khadidja Haidara
    Departement de Chimie, TOXEN, Universite du Quebec a Montreal, Montreal, Canada
    Toxicol Appl Pharmacol 229:65-76. 2008
    ..This study demonstrates that caspase-9 and caspase-12 are activated in t-BHP-induced apoptosis in hepatocytes. We highlight the importance of subcellular compartments such as mitochondria, ER and nuclei in the apoptotic process...
  83. doi Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound model
    Qixu Zhang
    Division of Plastic Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    J Invest Dermatol 128:2102-12. 2008
    ..These results indicate that HBO improves ischemic wound healing by downregulation of HIF-1alpha and subsequent target gene expression with attenuation of cell apoptosis and reduction of inflammation...
  84. pmc P2X(7) nucleotide receptors mediate caspase-8/9/3-dependent apoptosis in rat primary cortical neurons
    Qiongman Kong
    Interdisciplinary Neuroscience Program, University of Missouri Columbia, Columbia, Missouri, USA
    Purinergic Signal 1:337-47. 2005
    ..Taken together, these data indicate that extracellular nucleotides mediate neuronal apoptosis through activation of P2X(7)Rs and their downstream signaling pathways involving JNK1, ERK and caspases 8/9/3...
  85. doi Antiapoptosis and mitochondrial effect of pioglitazone preconditioning in the ischemic/reperfused heart of rat
    Jian Li
    Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No 1277 Jiefang Road, Wuhan 430022, China
    Cardiovasc Drugs Ther 22:283-91. 2008
    ..Furthermore, we investigated whether the protective effect of pioglitazone was related to opening of the mitochondrialATP-sensitive potassium channels...
  86. doi Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain
    Juliet C Russell
    The Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, Maryland, USA
    J Neurochem 106:1357-70. 2008
    ..HI triggered the mitochondrial release of cytochrome c, Smac/DIABLO, and caspase 3 activation...
  87. pmc Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis
    Arabinda Das
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 86:2992-3001. 2008
    ..From these findings, we conclude that increases in calpain and caspase activities play crucial roles in neuronal apoptosis during the development of acute EAE...
  88. doi Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model
    Jianmei Cai
    Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, PR China
    Neurosci Lett 441:167-72. 2008
    ..These results indicated H2 administration after HI appeared to provide brain protection via inhibition of neuronal apoptosis...
  89. doi Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation
    M Bhattacharjee
    Department of Laboratory Medicine, School of Tropical Medicine, 108, Chittaranjan Avenue Road, Kolkata 700073
    Int Immunol 20:1489-505. 2008
    ..The present work focuses on the mechanistic approach of how T11TS mediates apoptosis and hence is the first approach of its kind in the field of immunology where the immunotherapeutic molecule's mode of action has been worked out...
  90. doi Inhibition of nNOS reduces ischemic cell death through down-regulating calpain and caspase-3 after experimental stroke
    Ming Sun
    Department of Neurochemistry, Beijing Neurosurgical Institute, China
    Neurochem Int 54:339-46. 2009
    ....
  91. ncbi Caspase-dependent retinal ganglion cell apoptosis in the rat model of acute diabetes
    Yong hao Li
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, Guangdong, China
    Chin Med J (Engl) 121:2566-71. 2008
    ..Neural apoptosis is generally believed to be mediated by two distinct pathways, caspase-dependant and caspase-independent pathways. This study investigated the apoptotic pathways involved in retinal ganglion cells in acute diabetes in rats...
  92. pmc Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunction
    Jeejabai Radhakrishnan
    Medical Service 111F North Chicago VA Medical Center, 3001 Green Bay Road, North Chicago, IL 60064, USA
    Am J Physiol Heart Circ Physiol 296:H1164-74. 2009
    ..Concomitant activation of intrinsic antiapoptotic mechanisms could play a protective role downstream to caspase-3 activation...
  93. pmc The many roles of FAS receptor signaling in the immune system
    Andreas Strasser
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Vic, Australia
    Immunity 30:180-92. 2009
    ..This review describes current understanding of Fas-induced apoptosis signaling and proposes experimental strategies for future advances...
  94. pmc Vasoactive intestinal peptide inhibits TNF-alpha-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands
    Mario Calafat
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, Buenos Aires, Argentina
    Arthritis Res Ther 11:R53. 2009
    ..Our goal was to analyse the effect of TNF-alpha on apoptotic mediators in isolated acinar cells from NOD submandibular gland and their modulation by VIP...
  95. doi Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Neurosci Lett 459:47-51. 2009
    ..Based on the current data, it could be concluded that high glucose-induced apoptosis in PC12 cells is mediated, in part, by activation of caspase-8, -9, and -3 dependent pathways...
  96. doi Tocotrienol attenuates oxidative-nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy
    Anurag Kuhad
    Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160 014, India
    Neuropharmacology 57:456-62. 2009
    ....
  97. doi Attenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamol
    Anurag Kuhad
    Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160 014, India
    J Agric Food Chem 57:6123-8. 2009
    ..The data reveal that sesamol modulates the release of profibrotic cytokines, oxidative stress, ongoing chronic inflammation, and apoptosis and thus exerts a marked renoprotective effect...
  98. doi Evaluation of transcriptional activity of caspase-3 gene as a marker of acute neurotoxicity in rat cerebellar granular cells
    Jaume Folch
    Unitat de Bioquimica, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, C St Llorenç 21, 43201 Reus, Tarragona, Spain
    Toxicol In Vitro 24:465-71. 2010
    ..Transcriptional activity of caspase-3 correlates significantly with these changes and it could be a good indicator of acute neurotoxicity...
  99. ncbi [Expression of caspase-3 in rat kidney with renal tubular damage induced by lipopolysaccharide and hypoxia]
    Fang Yang
    Department of Pediatrics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510630, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2091-3. 2009
    ..To observe the expression of caspase-3 in the kidney of a rat model of renal tubular damage induced by endotoxin and hypoxia and explore the mechanism of renal tubular damage...
  100. doi Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos
    Shiva Nasiraei-Moghadam
    Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    J Mol Neurosci 41:156-64. 2010
    ..Immunohistochemical assay was used to reveal the protein expression of Bax, Bcl2, and the activation of caspase 3. The results showed a significant increase in Bax immunoreactivity in all of the mentioned embryonic days (E9...

Research Grants16

  1. Cellular Mechanisms of Preconditioning Neuroprotection
    BethAnn McLaughlin; Fiscal Year: 2009
    ..These studies will provide novel insight into endogenous molecular events that can be exploited to enhance neuronal survival. ..
  2. SEROTONIN (5-HT) RECEPTORS AND SALIVARY GLAND FUNCTION
    GARY WEISMAN; Fiscal Year: 2002
    ....
  3. Novel Mechanisms of Chronic Inflammation in Sjogren's Syndrome
    GARY ANDREW WEISMAN; Fiscal Year: 2010
    ..These studies should lead to better therapeutic strategies for minimizing autoimmune-associated inflammation of salivary gland that contributes to xerostomia in patients with SS. ..
  4. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..
  5. STRUCTURE/FUNCTION OF TRK RECEPTORS FOR NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2001
    ....
  6. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    ....
  7. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  8. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  9. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  10. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  11. HSP25 and HSP20 Regulation in Skeletal Muscle Adapt
    KIMBERLY HUEY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  12. STRUCTURE/FUNCTION OF NERVE GROWTH FACTOR/NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2009
    ..abstract_text> ..
  13. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  14. Calcium Homeostasis and Neonatal Brain Injury
    Christopher Turner; Fiscal Year: 2009
    ....
  15. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2009
    ....