Camk2a

Summary

Gene Symbol: Camk2a
Description: calcium/calmodulin-dependent protein kinase II alpha
Alias: PK2CDD, PKCCD, calcium/calmodulin-dependent protein kinase type II subunit alpha, Ca2+/calmodulin-dependent protein kinase II alpha, alpha CaM kinase II, caM kinase II subunit alpha, caM-kinase II alpha chain, caMK-II subunit alpha, calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha, calcium/calmodulin-dependent protein kinase II alpha subunit, calcium/calmodulin-dependent protein kinase type II alpha chain
Species: rat

Top Publications

  1. pmc Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors
    Guang Yin Xu
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Proc Natl Acad Sci U S A 101:11868-73. 2004
  2. pmc The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure
    Ken ichi Okamoto
    RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:6418-23. 2007
  3. doi Activity-dependent regulation of the dopamine transporter is mediated by Ca(2+)/calmodulin-dependent protein kinase signaling
    Shalini Padmanabhan
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Eur J Neurosci 28:2017-27. 2008
  4. pmc Heterosynaptic molecular dynamics: locally induced propagating synaptic accumulation of CaM kinase II
    Jacqueline Rose
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    Neuron 61:351-8. 2009
  5. pmc Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor
    Rebekah S Vest
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    J Biol Chem 285:20675-82. 2010
  6. ncbi Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation
    K Shen
    Department of Cell Biology and Department of Pharmacology and Cancer Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Science 284:162-6. 1999
  7. ncbi Localization of CaMKIIalpha in rat primary sensory neurons: increase in inflammation
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Brain Res 947:252-9. 2002
  8. ncbi Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia
    Koji Osuka
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Japan
    J Cereb Blood Flow Metab 22:1098-106. 2002
  9. ncbi Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII
    Charles C Fink
    Department of Molecular Pharmacology, Stanford University Medical School, Stanford, CA 94305, USA
    Neuron 39:283-97. 2003
  10. ncbi Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation
    Maddalena Illario
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli, 80131 Italy
    J Biol Chem 278:45101-8. 2003

Research Grants

  1. PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAIN
    Susan Carlton; Fiscal Year: 2004
  2. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
  3. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
  4. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
  5. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
  6. Modes of Neurotoxicity in the Mammalian Retina
    DENNIS GOEBEL; Fiscal Year: 2006
  7. Cell-permeable inibitors specific for CaMKII
    K Ulrich Bayer; Fiscal Year: 2006
  8. CaMKII signaling in insulin secretion and response
    K Ulrich Bayer; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications129 found, 100 shown here

  1. pmc Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors
    Guang Yin Xu
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Proc Natl Acad Sci U S A 101:11868-73. 2004
    ....
  2. pmc The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure
    Ken ichi Okamoto
    RIKEN MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:6418-23. 2007
    ..This finding indicates that CaMKII serves as a central signaling molecule in both functional and structural changes during synaptic plasticity...
  3. doi Activity-dependent regulation of the dopamine transporter is mediated by Ca(2+)/calmodulin-dependent protein kinase signaling
    Shalini Padmanabhan
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Eur J Neurosci 28:2017-27. 2008
    ..These data suggest that neuronal activity can regulate dopamine transporter function and abundance via calcium/CaM kinase II signaling...
  4. pmc Heterosynaptic molecular dynamics: locally induced propagating synaptic accumulation of CaM kinase II
    Jacqueline Rose
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    Neuron 61:351-8. 2009
    ..L-IPS translocation of CaMKII alters biochemical signaling and is associated with an increase in AMPA receptor GluR1 at both stimulated and nonstimulated synapses and thus provides a molecular mechanism for heterosynaptic plasticity...
  5. pmc Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor
    Rebekah S Vest
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    J Biol Chem 285:20675-82. 2010
    ..Together, these data demonstrate that inhibition of autonomous CaMKII activity provides a promising therapeutic avenue for post-insult neuro-protection after stroke...
  6. ncbi Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation
    K Shen
    Department of Cell Biology and Department of Pharmacology and Cancer Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Science 284:162-6. 1999
    ..Autophosphorylation of CaMKII indirectly prolongs its PSD localization by increasing the calmodulin-binding affinity...
  7. ncbi Localization of CaMKIIalpha in rat primary sensory neurons: increase in inflammation
    Susan M Carlton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Brain Res 947:252-9. 2002
    ....
  8. ncbi Phosphorylation of neuronal nitric oxide synthase at Ser847 by CaM-KII in the hippocampus of rat brain after transient forebrain ischemia
    Koji Osuka
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Japan
    J Cereb Blood Flow Metab 22:1098-106. 2002
    ....
  9. ncbi Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII
    Charles C Fink
    Department of Molecular Pharmacology, Stanford University Medical School, Stanford, CA 94305, USA
    Neuron 39:283-97. 2003
    ..These results show that the two main neuronal CaMKII isoforms have markedly different roles in neuronal plasticity, with CaMKIIalpha regulating synaptic strength and CaMKIIbeta controlling the dendritic morphology and number of synapses...
  10. ncbi Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation
    Maddalena Illario
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Federico II, Napoli, 80131 Italy
    J Biol Chem 278:45101-8. 2003
    ..These findings also provide evidence supporting the possible existence of cross-talk between other intracellular pathways involving CaMKII and Raf-1...
  11. ncbi Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
    A J Robison
    Department of Molecular Physiology and Biophysics, Center for Molecular Neuroscience, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 280:35329-36. 2005
    ....
  12. pmc Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B
    K Ulrich Bayer
    Department of Pharmacology, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 26:1164-74. 2006
    ..This activity-dependent incorporation of CaMKII into postsynaptic sites may play a role in maturation and plasticity of synapses...
  13. ncbi Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors
    Catriona M Houston
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    J Biol Chem 282:17855-65. 2007
    ..These findings were confirmed in a neuronal environment by expressing recombinant GABA(A) receptors in cerebellar granule neurons...
  14. ncbi CaMKIIalphaB mediates a survival response in retinal ganglion cells subjected to a glutamate stimulus
    Wei Fan
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Invest Ophthalmol Vis Sci 48:3854-63. 2007
    ..The purpose of this study was to investigate whether CaMKIIalphaB is present specifically in retinal ganglion cells (RGCs) and to determine whether it can be implicated in the cell death or cell survival of signal transduction pathways...
  15. ncbi Secondary hyperalgesia in the postoperative pain model is dependent on spinal calcium/calmodulin-dependent protein kinase II alpha activation
    Toni L Jones
    Department of Anesthesiology, University of California San Diego, La Jolla, California 92093 0818, USA
    Anesth Analg 105:1650-6, table of contents. 2007
    ..In the present study, we investigated whether spinal calcium/calmodulin-dependent protein kinase IIalpha (CaMKIIalpha) mediates 1 degree and/or 2 degrees hyperalgesia and spontaneous pain behavior after plantar incision...
  16. ncbi Synaptic strength of individual spines correlates with bound Ca2+-calmodulin-dependent kinase II
    Brent Asrican
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 27:14007-11. 2007
    ..The results are consistent with the hypothesis that bound CaMKII serves as a structural organizer of postsynaptic molecules and thereby may be involved in maintaining spine size and synaptic strength...
  17. pmc Multiplexed dendritic targeting of alpha calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway
    Yuanzheng Gao
    Neuroscience Program, Department of Molecular Microbial and Structural Biology, University of Connecticut Health Center, Farmington CT 06030, USA
    Mol Biol Cell 19:2311-27. 2008
    ..Multiplexed dendritic targeting of different RNAs by the same pathway represents a new organizing principle for coordinating gene expression at the synapse...
  18. doi Chronic, but not acute morphine treatment, up-regulates alpha-Ca2+/calmodulin dependent protein kinase II gene expression in rat brain
    Yuejun Chen
    Pharmacology Research Center and State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai 200032, China
    Neurochem Res 33:2092-8. 2008
    ..Taken together, our data demonstrate that chronic morphine treatment region-specific up-regulates the levels of the alpha-CaMK II gene expression in hippocampus and frontal cortex...
  19. pmc A novel role for calcium/calmodulin kinase II within the brainstem pedunculopontine tegmentum for the regulation of wakefulness and rapid eye movement sleep
    Edward C Stack
    Laboratory of Sleep and Cognitive Neurosciences, Boston University School of Medicine, Boston, Massachusetts, USA
    J Neurochem 112:271-81. 2010
    ....
  20. pmc Depression of Ca(2+)/calmodulin-dependent protein kinase II in dorsal root ganglion neurons after spinal nerve ligation
    Sanja Lovric Kojundzic
    Department of Anatomy, Histology and Embryology, University of Split School of Medicine, 21000 Split, Croatia
    J Comp Neurol 518:64-74. 2010
    ..These results indicate that diminished afferent activity after axotomy may lead to decreased phosphorylation of CaMKIIalpha...
  21. pmc The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury
    Margarita A Salas
    Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Medicas, 60 y 120, 1900 La Plata, Argentina
    J Mol Cell Cardiol 48:1298-306. 2010
    ..The results reveal an apoptotic-necrotic pathway mediated by CaMKII-dependent phosphorylations at the SR, which involves the reverse NCX mode and the mitochondria as trigger and end effectors, respectively, of the cascade...
  22. pmc CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action
    Hyun Jae Pi
    Quantitative Biology Program, Physics Department, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 107:14437-42. 2010
    ..This form fails to enhance synaptic strength but increases spine size, presumably by a structural process. Thus very different mechanisms govern how CaMKII affects spine structure and synaptic function...
  23. doi CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin
    Patricio Opazo
    CNRS UMR 5091, Cellular Physiology of the Synapse, Bordeaux, France
    Neuron 67:239-52. 2010
    ..Thus, NMDA-dependent Ca(2+) influx in the post-synapse triggers a CaMKII- and Stargazin-dependent decrease in AMPAR diffusional exchange at synapses that controls synaptic function...
  24. doi Ca2+/calmodulin-dependent protein kinase II and protein kinase C activities mediate extracellular glucose-regulated hippocampal synaptic efficacy
    Shigeki Moriguchi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Mol Cell Neurosci 46:101-7. 2011
    ..Taken together, CaMKII and PKC activation likely mediate potentiation of fEPSPs by elevated glucose levels, and CaMKII activity is also associated with LTP induction in the hippocampal CA1 region...
  25. pmc Selective translocation of Ca2+/calmodulin protein kinase IIalpha (CaMKIIalpha) to inhibitory synapses
    Kurt C Marsden
    Dominick P Purpura Department of Neuroscience, The Rose Kennedy Center for Mental Retardation, The Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:20559-64. 2010
    ..This preferential targeting of CaMKIIα to glutamatergic or GABAergic synapses provides neurons with a mechanism whereby activity can selectively potentiate excitation or inhibition through a single kinase mediator...
  26. pmc Mechanisms of CaMKII action in long-term potentiation
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 13:169-82. 2012
    ..These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse...
  27. doi Nonlinear decoding and asymmetric representation of neuronal input information by CaMKIIα and calcineurin
    Hajime Fujii
    Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Rep 3:978-87. 2013
    ..These results provide evidence that CaMKIIα and calcineurin are fine-tuned to unique bandwidths and compute input variables in an asymmetric manner...
  28. ncbi Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway
    Bong Gun Ju
    Howard Hughes Medical Institute, University of California, San Diego, Department and School of Medicine, La Jolla, CA 92093, USA
    Cell 119:815-29. 2004
    ..The identification of PARP-1 as a regulated promoter-specific exchange factor required for activation of specific neurogenic gene programs is likely to be prototypic of similar molecular mechanisms...
  29. ncbi Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin
    R S Walikonis
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 21:423-33. 2001
    ....
  30. ncbi The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner
    Rani Dhavan
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 22:7879-91. 2002
    ....
  31. ncbi Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats
    Bo Song
    Research Center of Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou 221002, Jiangsu, PR China
    Neurosci Lett 349:183-6. 2003
    ....
  32. ncbi A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins
    Tatsuo Suzuki
    Department of Neuroplasticity, Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Eur J Neurosci 21:339-50. 2005
    ..These results suggest that TANC protein may work as a postsynaptic scaffold component by forming a multiprotein complex with various postsynaptic density proteins...
  33. ncbi Long-term potentiation is mediated by multiple kinase cascades involving CaMKII or either PKA or p42/44 MAPK in the adult rat dentate gyrus in vitro
    JianQun Wu
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurophysiol 95:3519-27. 2006
    ..Thus LTP is mediated by either of two parallel cascades, one involving CaMKII and the other PKA or MAPK. Moreover, these cascades are active for a certain period after the induction stimulus...
  34. doi CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking
    Sharon M Anderson
    Department of Pharmacology, Boston University School of Medicine, 715 Albany Street, L603, Boston, Massachusetts 02118, USA
    Nat Neurosci 11:344-53. 2008
    ..Thus, CaMKII may be an essential link between accumbens shell dopamine and glutamate systems involved in the neuronal plasticity underlying cocaine craving and relapse...
  35. doi Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons
    Dennis J Goebel
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Brain Res 1256:190-204. 2009
    ....
  36. pmc CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death
    Sujuan Chen
    College of Life Sciences, Nanjing Normal University, Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, Nanjing, China
    J Neurochem 119:1108-18. 2011
    ..Our findings underscore a central role of CaMKII in the neurotoxicology of Cd, and suggest that manipulation of intracellular Ca(2+) level or CaMKII activity may be exploited for prevention of Cd-induced neurodegenerative disorders...
  37. doi Diabetes mellitus affects activity of calcium/calmodulin-dependent protein kinase II alpha in rat trigeminal ganglia
    Milka Jeric
    Department of Anatomy, Histology and Embryology, University of Split, School of Medicine, Soltanska 2, 21000 Split, Croatia
    J Chem Neuroanat 64:12-9. 2015
    ..In future, innovative strategies for modulation of CaMKIIα activity in specific subpopulations of neurons could be a novel approach in therapy of diabetic trigeminal neuropathy. ..
  38. pmc Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy
    Ersilia Cipolletta
    Department of Medicine and Surgery, University of Salerno, Baronissi SA, Italy
    PLoS ONE 10:e0130477. 2015
    ..We hypothesize that CaMKII association with extracellular regulated kinase (ERK), promotes cardiac hypertrophy through ERK nuclear localization...
  39. pmc CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation
    Per Holmfeldt
    Department of Molecular Biology, Umea University, Umea, Sweden
    EMBO J 24:1256-66. 2005
    ..These two mechanisms, involving CaMKIIgamma and TOGp, respectively, are both essential for spindle bipolarity in a normal physiological context, but not in MCAK-depleted cells...
  40. ncbi [Effect of iodine deficiency and hypothyroidism on the protein expressions of CaMK II in the hippocampus of pups]
    Wei Wei
    Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110001, China
    Wei Sheng Yan Jiu 39:180-3. 2010
    ..To observe the effect of iodine deficiency and hypothyroidism on the protein expressions of CaMK II in the hippocampus of pups...
  41. doi Regional alterations of JNK3 and CaMKIIα subunit expression in the rat brain after soman poisoning
    G Ramarao
    Division of Biochemistry, Defense Research and Development Establishment, Gwalior, Madhya Pradesh, India
    Hum Exp Toxicol 30:448-59. 2011
    ..CaMKII activity was increased in cerebrum and decreased in cerebellum. Results suggest that altered expression of both the protein kinases play a role in nerve agent-induced long-term neurotoxic effects...
  42. pmc Role of the CaMKII/NMDA receptor complex in the maintenance of synaptic strength
    Magdalena Sanhueza
    Department of Biology, Faculty of Sciences, University of Chile, Santiago, Santiago 7800024, Chile
    J Neurosci 31:9170-8. 2011
    ..These results support the hypothesis that the CaMKII/NMDAR complex has switch-like properties that are important in the maintenance of synaptic strength...
  43. pmc Glucocorticoid receptors recruit the CaMKIIα-BDNF-CREB pathways to mediate memory consolidation
    Dillon Y Chen
    Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1707-14. 2012
    ..Thus, glucocorticoid receptors mediate long-term memory formation by recruiting the CaMKIIα-BDNF-CREB-dependent neural plasticity pathways...
  44. pmc Role of nociceptor αCaMKII in transition from acute to chronic pain (hyperalgesic priming) in male and female rats
    Luiz F Ferrari
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 33:11002-11. 2013
    ..Our results demonstrate a contribution of αCaMKII to induction of hyperalgesic priming, a phenomenon implicated in the transition from acute to chronic pain. ..
  45. pmc Ca²⁺/calmodulin-dependent protein kinase II contributes to hypoxic ischemic cell death in neonatal hippocampal slice cultures
    Qing Lu
    Vascular Biology Center, Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 8:e70750. 2013
    ..In a neonatal rat model of HI, KN93 also reduced brain injury. Our results suggest that CaMKII activation contributes to the oxidative stress associated with neural cell death after HI...
  46. pmc Differential regulation of CaMKIIα interactions with mGluR5 and NMDA receptors by Ca(2+) in neurons
    Dao Zhong Jin
    Department of Basic Medical Science, School of Medicine, University of Missouri Kansas City, Kansas City, Missouri, USA
    J Neurochem 127:620-31. 2013
    ..This agonist-induced cascade seems to mediate crosstalk between mGluR5 and NMDA receptors in neurons. ..
  47. pmc Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses
    Julien P Dupuis
    Interdisciplinary Institute for Neuroscience University de Bordeaux UMR 5297, Bordeaux, France
    EMBO J 33:842-61. 2014
    ..We thus uncover a non-canonical mechanism by which GluN2B-NMDAR surface dynamics plays a critical role in the plasticity of maturing synapses through a direct interplay with CaMKII. ..
  48. pmc Muscle-type specific autophosphorylation of CaMKII isoforms after paced contractions
    Wouter Eilers
    School of Healthcare Science, Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Manchester M1 5GD, UK Laboratory for Myology, Faculty of Human Movement Sciences, MOVE Research Institute Amsterdam, VU University Amsterdam, 1081 BT Amsterdam, The Netherlands
    Biomed Res Int 2014:943806. 2014
    ..The findings expose that CaMKII autophosphorylation with paced contractions is regulated in an isoform and muscle type-specific fashion and highlight properties emerging for phenotype-specific regulation of CaMKII. ..
  49. doi NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII
    Stefan Wagner
    Dept Internal Medicine II, University Hospital Regensburg, Regensburg, Germany Clinic for Cardiology and Pneumology, Georg August University Gottingen, and DZHK German Centre for Cardiovascular Research, partner site Göttingen, Germany
    J Mol Cell Cardiol 75:206-15. 2014
    ..Interestingly, cAMP-dependent protein kinase A (PKA) which regulates similar targets as CaMKII has recently been shown to be redox-sensitive as well...
  50. doi CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease
    Xia Jiang
    Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, P R China Department of Pathology, Hubei University of Chinese Medicine, Wuhan, Hubei Province, P R China
    Neurobiol Aging 36:867-76. 2015
    ..We conclude that spatial training can preserve the cognitive function by CaMKII-dependent remodeling of dendritic plasticity in hyperhomocysteinemia-induced sporadic AD-like rats. ..
  51. pmc CaMKIIα knockdown decreases anxiety in the open field and low serotonin-induced upregulation of GluA1 in the basolateral amygdala
    Lee Tran
    Institute for Biomedical Studies, Baylor University, Waco, TX, USA
    Behav Brain Res 303:152-9. 2016
    ..Our results suggest that the CaMKII signaling plays a key role in low 5-HT-induced anxiety and mood disturbances, potentially through regulation of GluA1 expression in the BLA. ..
  52. pmc Independent localization of MAP2, CaMKIIα and β-actin RNAs in low copy numbers
    Martin Mikl
    Center for Brain Research, Department of Neuronal Cell Biology, Medical University of Vienna, Spitalgasse 4, Wien 1090, Austria
    EMBO Rep 12:1077-84. 2011
    ..Our data suggest that the independent localization of individual RNAs in low copy numbers could contribute to tighter temporal and spatial control of expression in neurons and synapse-specific plasticity...
  53. doi TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons
    Zhuohao He
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 32:9383-95. 2012
    ..In contrast, the Ca(2+) influx through TRPC6 induced by NT-4 promoted the dendritic growth. Thus, TRPC5 acts as a novel and specific mediator for NT-3 to regulate dendrite development through CaMKIIα...
  54. pmc Glutamate receptor subunit and calmodulin kinase II expression, with and without T maze training, in the rat hippocampus following bilateral vestibular deafferentation
    Yiwen Zheng
    Department of Pharmacology and Toxicology, School of Medical Sciences, and the Brain Health Research Centre, University of Otago Medical School, Dunedin, New Zealand
    PLoS ONE 8:e54527. 2013
    ..Given the importance of glutamate as a neurotransmitter in the hippocampus, it was predicted that bilateral vestibular deafferentation (BVD) would alter the expression of NMDA and AMPA receptors in this area of the brain...
  55. pmc The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
    D Stokoe
    Department of Biochemistry, University of Dundee, Scotland, UK
    Biochem J 296:843-9. 1993
    ..The threonine residue phosphorylated by MAP kinase lies immediately C-terminal to the catalytic domain and is followed by a nuclear localization signal, Lys-Lys-(Xaa)10-Lys-Arg-Arg-Lys-Lys, near the C-terminus...
  56. ncbi Subcellular distribution and phosphorylation of the nuclear localization signal binding protein, NBP60
    S Kawahire
    Department of Biochemistry, Faculty of Science, Niigata University, Japan
    Exp Cell Res 222:385-94. 1996
    ..The phosphorylation of NBP60 by cdc2 kinase and/or the other kinases may be related to the change in the protein's location during the mitotic phase...
  57. ncbi Determining calmodulin binding to metabotropic glutamate receptors with distinct protein-interaction methods
    K Lidwell
    Neuroscience Group, University of Southampton, Southampton, UK
    Biochem Soc Trans 32:868-70. 2004
    ..This illustrates that certain Ca(2+)-dependent interactions are not recapitulated in yeast. Moreover, it highlights the necessity for supporting biochemical data to substantiate interactions identified with Y2H methods...
  58. doi Direct visualization of CaMKII at postsynaptic densities by electron microscopy tomography
    Andrea Fera
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Comp Neurol 520:4218-25. 2012
    ..CaMKII molecules found in the core of the PSD may represent a pool distinct from the CaMKII residing at the cytoplasmic surface...
  59. pmc CaMKII regulation in information processing and storage
    Steven J Coultrap
    Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Trends Neurosci 35:607-18. 2012
    ..Recent findings also implicate CaMKII in long-term depression (LTD), as well as functional roles at inhibitory synapses, lending renewed emphasis on better understanding the spatiotemporal control of CaMKII regulation...
  60. pmc CaMKII is essential for the function of the enteric nervous system
    Na Gao
    Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas, USA
    PLoS ONE 7:e44426. 2012
    ..In this study, we investigated the function and expression pattern of CaMKII in the ENS across several mammalian species...
  61. pmc Gating of long-term depression by Ca2+/calmodulin-dependent protein kinase II through enhanced cGMP signalling in cerebellar Purkinje cells
    Shin ya Kawaguchi
    Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Physiol 591:1707-30. 2013
    ..Thus, this study clarified interaction between NO and Ca(2+)/CaMKII, two important factors required for LTD...
  62. pmc Phosphorylated CaMKII levels increase in rat central nervous system after large-dose intravenous remifentanil
    Qiang Wang
    Department of Anesthesia, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China
    Med Sci Monit Basic Res 19:118-25. 2013
    ..This study was designed to determine how CaMKII phosphorylation and protein expression levels change in the central nervous system of rats with remifentanil-induced hyperalgesia...
  63. pmc Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels and CaMKII functions regulating protein turnover in the hippocampus
    Weber Cláudio da Silva
    Centro de Memoria, Instituto do Cérebro, Pontificia Universidade Catolica do Rio Grande do Sul, RS90610 000 Porto Alegre, Brazil
    Proc Natl Acad Sci U S A 110:6566-70. 2013
    ....
  64. pmc Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling
    Leena Rauhala
    School of Medicine, Institute of Biomedicine Anatomy, University of Eastern Finland, Kuopio Campus, Yliopistonranta 1 E, P O Box 1627, 70211 Kuopio, Finland
    J Biol Chem 288:17999-8012. 2013
    ..The simultaneously enhanced catabolism of hyaluronan demonstrates the complexity of the UVB-induced changes. Nevertheless, enhanced hyaluronan metabolism is an important part of the adaptation of keratinocytes to radiation injury. ..
  65. doi Expression of phospho-Ca(2+) /calmodulin-dependent protein kinase II in the pre-Bötzinger complex of rats
    Jun Jun Kang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    J Neurochem 126:349-59. 2013
    ..In somas, CaMKII acts on both symmetric and asymmetric synapses, mediating excitatory and inhibitory synaptic transmission. P-CaMKII was also localized to the perisynaptic and extrasynaptic regions in the pre-BötC. ..
  66. doi Sequestration of CaMKII in dendritic spines in silico
    Shahid Khan
    Laboratory of Neurobiology, National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892, USA
    J Comput Neurosci 31:581-94. 2011
    ..The computations revealed that self-aggregation could provide a concentration-dependent switch to amplify CaMKII sequestration and regulate its activity depending on its occupancy of the actin cytoskeleton...
  67. doi Single-prolonged stress induce changes of CaM/CaMKIIα in the rats of dorsal raphe nucleus
    Huaju Xie
    Department of Histology and Embryology, Institute of Pathology and Pathophysiology, Basic Medical Sciences College, China Medical University, 92 North 2nd Road, Shenyang 110001, Liaoning Province, People s Republic of China
    Neurochem Res 37:1043-9. 2012
    ..Our results confirm that SPS induce changes of CaM/CaMKIIα in the dorsal raphe nucleus. Changes of CaM/CaMKIIα may be associated with the activation of 5-HT1A receptor, and may contribute to the progress of molecular mechanism of PTSD...
  68. doi Acute exposure of L6 myotubes to cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers stimulates glucose uptake by modulating Ca2+/calmodulin-dependent protein kinase II
    Suresh K Mohankumar
    Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
    Int J Biochem Cell Biol 44:1321-30. 2012
    ..Given that impairments in muscle glucose utilisation are apparent in metabolic syndrome, delineating the molecular mechanisms by which CLA isomers mediate muscle glucose uptake may identify new approaches to manage this condition...
  69. ncbi The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
    K O Cho
    Division of Biology, California Institute of Technology, Pasadena 91125
    Neuron 9:929-42. 1992
    ..The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain...
  70. pmc Sequence analysis and DNA-protein interactions within the 5' flanking region of the Ca2+/calmodulin-dependent protein kinase II alpha-subunit gene
    T Sunyer
    Cell Biology Division, Wellcome Research Laboratories, Research Triangle Park, NC 27709
    Proc Natl Acad Sci U S A 87:278-82. 1990
    ....
  71. pmc Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase
    C R Lin
    Proc Natl Acad Sci U S A 84:5962-6. 1987
    ..The domain organization suggests a structural model for calcium/calmodulin-dependent and independent states that might subserve short- and long-term responses to transient stimuli...
  72. ncbi Two cis-acting elements in the 3' untranslated region of alpha-CaMKII regulate its dendritic targeting
    Y Mori
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka Suita, Osaka 565 0871, Japan
    Nat Neurosci 3:1079-84. 2000
    ..This inhibition was removed in depolarized neurons, and such activity-dependent derepression was a primary requirement for their dendritic targeting...
  73. ncbi Identification of a cis-acting dendritic targeting element in the mRNA encoding the alpha subunit of Ca2+/calmodulin-dependent protein kinase II
    A Blichenberg
    Institute for Cell Biochemistry and Clinical Neurobiology, University of Hamburg, University Hospital Eppendorf, Süderfeldstr 24, D 22529 Hamburg, Germany
    Eur J Neurosci 13:1881-8. 2001
    ..These findings imply that extrasomatic sorting of individual dendritic mRNAs involves at least partially distinct molecular mechanisms, as well as large trafficking complexes...
  74. ncbi [Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions]
    Hideyuki Yamamoto
    Tanpakushitsu Kakusan Koso 47:241-7. 2002
  75. ncbi Persistent phosphorylation of synaptic proteins following middle cerebral artery occlusion
    Shohei Matsumoto
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University Hospital, Sweden
    J Cereb Blood Flow Metab 22:1107-13. 2002
    ....
  76. ncbi Mechanisms for regulation of calmodulin kinase IIalpha by Ca(2+)/calmodulin and autophosphorylation of threonine 286
    David Chin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biochemistry 41:14001-9. 2002
    ....
  77. ncbi Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII
    Kara G Pratt
    Department of Biology, Volen National Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Neuron 39:269-81. 2003
    ..These data suggest that postsynaptic activation of CaMKII induces a structural remodeling of presynaptic inputs that favors the retention of active presynaptic partners...
  78. ncbi CyclinB1 expression is elevated and mitosis is delayed in HeLa cells expressing autonomous CaMKII
    Shirelyn R Beauman
    Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Cell Signal 15:1049-57. 2003
    ..Taken together, these data suggest that constitutive CaMKII may delay mitosis by activating a cell cycle checkpoint...
  79. ncbi Protein kinase C-gamma and calcium/calmodulin-dependent protein kinase II-alpha are persistently translocated to cell membranes of the rat brain during and after middle cerebral artery occlusion
    Shohei Matsumoto
    Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    J Cereb Blood Flow Metab 24:54-61. 2004
    ..Drugs preventing PKC and/or CaMKII-alpha translocation may prove beneficial against ischemic cell death...
  80. ncbi Ca2+/calmodulin-dependent protein kinase II in the rat cranial sensory ganglia
    H Ichikawa
    Department of Oral Function and Anatomy, Shikata cho, Okayama, Japan
    Brain Res 1005:36-43. 2004
    ..8% of trigeminal neurons which were retrogradely traced with fluorogold from the facial skin and nasal mucosa exhibited CaMKII-ir. Forty-six percent of petrosal neurons which innervated the soft palate were immunoreactive for the enzyme...
  81. ncbi Sustained beta1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway
    Wang Wang
    Laboratory of Cardiovascular Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Circ Res 95:798-806. 2004
    ..This finding may bear important etiological and therapeutical ramifications in understanding beta1AR signaling in chronic heart failure...
  82. ncbi Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons
    Jarin Hongpaisan
    Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4062, USA
    J Neurosci 24:10878-87. 2004
    ..This mechanism also represents yet another way that mitochondria, acting as calcium sensors, can play a role in neuronal signal transduction...
  83. ncbi Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress
    Olivia S Gardner
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, North Carolina, 27599, USA
    J Biol Chem 280:10109-18. 2005
    ..Furthermore, using structural derivatives of TZDs that lack PPARgamma ligand-binding activity as well as a PPARgamma antagonist, we show that activation of these kinase signaling pathways is PPARgamma-independent...
  84. ncbi BAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-terminal myristoylation and palmitoylation, and interacts with alpha, but not beta, subunit of Ca/calmodulin-dependent protein kinase II
    Xin Wang
    Department of Neuroplasticity, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Neurochem 92:647-59. 2005
    ..These findings suggest that BAALC 1-6-8 protein play a synaptic role at the postsynaptic lipid raft possibly through interaction with CaMKIIalpha...
  85. ncbi Bidirectional synaptic plasticity regulated by phosphorylation of stargazin-like TARPs
    Susumu Tomita
    Department of Physiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuron 45:269-77. 2005
    ..These results establish stargazin as a critical substrate in the bidirectional control of synaptic strength, which is thought to underlie aspects of learning and memory...
  86. ncbi Synaptic activity and F-actin coordinately regulate CaMKIIalpha localization to dendritic postsynaptic sites in developing hippocampal slices
    Raheel Ahmed
    Department of Biological Sciences, 369 Biology Building, University of Iowa, Iowa City, IA 52242 1324, USA
    Mol Cell Neurosci 31:37-51. 2006
    ..Moreover, the timing of CaMKIIalpha recruitment to developing spines suggests a role for CaMKIIalpha in spine assembly and maintenance...
  87. ncbi A beta1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction
    Carmen C Sucharov
    University of Colorado Cardiovascular Institute, Campus Box B130, UCHSC, Denver, CO 80262, USA
    Am J Physiol Heart Circ Physiol 291:H1299-308. 2006
    ..We conclude that in neonatal rat cardiac myocytes, agonist-occupied beta1-AR mobilizes Ca2+ stores to activate fetal gene induction through cAMP independent pathways that involve CaMK...
  88. ncbi A mechanism for the inactivation of Ca2+/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo
    Y Yamagata
    Laboratory of Neurochemistry National Institute for Physiological Sciences, Myodaiji, Okazaki 444 8787, Japan
    Neuroscience 140:981-92. 2006
    ..Such a form of CaMKII may be important during pathological conditions in vivo in preventing excessive CaMKII activation due to Ca2+ overload...
  89. ncbi Differential modulation of Kv4.2 and Kv4.3 channels by calmodulin-dependent protein kinase II in rat cardiac myocytes
    Olaia Colinas
    Departamento de Bioquimica y Biologia Molecular y Fisiologia, Edificio IBGM, Universidad de Valladolid, C Sanz y Fores s n, 47003 Valladolid, Spain
    Am J Physiol Heart Circ Physiol 291:H1978-87. 2006
    ..3 provides a new role of Kv4.3 subunits as molecular scaffolds for concentrating CaMKII in the membrane, allowing Ca(2+)-dependent modulation by this enzyme of the associated Kv4.2 channels...
  90. ncbi Mechanisms for association of Ca2+/calmodulin-dependent protein kinase II with lipid rafts
    Feng Du
    Department of Neuroplasticity, Research Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Biochem Biophys Res Commun 347:814-20. 2006
    ..a. 261-309, 371-420, and 421-478). The multimeric structure of the full-length molecule also appeared to contribute to efficient lipid raft-targeting. Acylation of CaMKIIalpha did not appear to be a mechanism for the targeting...
  91. ncbi Calcium-calmodulin kinase II is the common factor in calcium-dependent cardiac expression and secretion of A- and B-type natriuretic peptides
    Jarkko J Ronkainen
    University of Oulu, Department of Physiology and Biocenter Oulu, University of Oulu, 90014 Oulu, Finland
    Endocrinology 148:2815-20. 2007
    ..This is a plausible mechanism contributing to exercise-induced natriuretic peptide secretion and the augmented secretion in heart dysfunction due to impaired calcium handling...
  92. ncbi Extracellular calcium induces activation of Ca(2+)/calmodulin-dependent protein kinase II and mediates spontaneous activation in rat oocytes
    Jae Gyu Yoo
    Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Canada J2S 7C6
    Biochem Biophys Res Commun 359:854-9. 2007
    ..Therefore, CaMKII is one of the upstream signals to activate rat oocytes spontaneously after recovery and rat oocytes respond very sensitively to extracellular calcium...
  93. ncbi Postsynaptic secretion of BDNF and NT-3 from hippocampal neurons depends on calcium calmodulin kinase II signaling and proceeds via delayed fusion pore opening
    Richard Kolarow
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, 55128 Mainz, Germany
    J Neurosci 27:10350-64. 2007
    ....
  94. ncbi Dynamics underlying synaptic gain between pairs of cortical pyramidal neurons
    Kara G Pratt
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Dev Neurobiol 68:143-51. 2008
    ..Our data suggest that activating CaMKII can increase synaptic connectivity through a CaM-dependent increase in contact formation, followed by stabilization of a constant fraction of new contacts...
  95. ncbi Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats
    Gin Den Chen
    Department of Physiology, College of Medicine, Chung Shan Medical University, No 110 Chang Kuo North Road Section 1, Taichung, Taiwan
    Am J Physiol Regul Integr Comp Physiol 294:R487-93. 2008
    ..Our findings suggest that a CaMKII-dependent NO/sGC/PKG pathway is involved in the RS-induced SRP, which has pathological relevance to hyperalgesia and allodynia...
  96. doi Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II
    Tao Song
    Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Biochem J 412:223-31. 2008
    ..This glutamate-induced S-nitrosylation was blocked by 7NI. These results suggest that inactivation of CaMKII mediated by S-nitrosylation at Cys(6) may contribute to NO-induced neurotoxicity in the brain...
  97. doi A two-state model for Ca2+/CaM-dependent protein kinase II (alphaCaMKII) in response to persistent Ca2+ stimulation in hippocampal neurons
    Paul A A Grant
    Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Cell Calcium 44:465-78. 2008
    ..Punctate deposition disables both the interactions and the activity of CaMKII...
  98. pmc Ethanol inhibition of recombinant NMDA receptors is not altered by coexpression of CaMKII-alpha or CaMKII-beta
    Minfu Xu
    Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, SC, USA
    Alcohol 42:425-32. 2008
    ..The results of this study suggest that CaMKII is not involved in regulating the acute ethanol sensitivity of NMDA receptors...
  99. pmc Optical induction of plasticity at single synapses reveals input-specific accumulation of alphaCaMKII
    Yan Ping Zhang
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Proc Natl Acad Sci U S A 105:12039-44. 2008
    ....
  100. doi Selective inhibition of cyclooxygenase-2 attenuates nitroglycerin-induced calmodulin-dependent protein kinase II alpha in rat trigeminal nucleus caudalis
    Hedvig Varga
    Department of Neurology, Albert Szent Gyorgyi Clinical Centre, University of Szeged, Semmelweis u 6, H 6725 Szeged, Hungary
    Neurosci Lett 451:170-3. 2009
    ..Thus this isoform may play a significant role in the induction of migraine. These data could help in the better understanding of the pathogenesis of headaches and the action of antimigraine drugs...
  101. pmc CAMKII activation is not required for maintenance of learning-induced enhancement of neuronal excitability
    Ori Liraz
    Department of Neurobiology, Faculty of Sciences, Haifa University, Haifa, Israel
    PLoS ONE 4:e4289. 2009
    ..Our data show that although CaMKII modulates the amplitude of AHP of pyramidal neurons in the piriform cortex, its activation is not required for maintaining learning-induced enhancement of neuronal excitability...

Research Grants9

  1. PERIPHERAL SOMATOSTATIN CONTROLS INFLAMMATORY PAIN
    Susan Carlton; Fiscal Year: 2004
    ..Peripheral SST receptors offer novel targets for nociceptor modulation and are likely targets for further development of non-opioid therapies to aid in reducing the pain and long-term deleterious changes that can accompany inflammation. ..
  2. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. MECHANISMS OF ADAPTATION AND EXCITATION
    John Lisman; Fiscal Year: 2002
    ....
  4. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  5. CRCNS: Memory Mechanisms: Modifiability and Stability
    John Lisman; Fiscal Year: 2007
    ..The insights derived are likely to be of importance in understanding diseases of memory and suggest strategies for therapeutic intervention. ..
  6. Modes of Neurotoxicity in the Mammalian Retina
    DENNIS GOEBEL; Fiscal Year: 2006
    ..abstract_text> ..
  7. Cell-permeable inibitors specific for CaMKII
    K Ulrich Bayer; Fiscal Year: 2006
    ..The inhibitor developed and characterized in this proposal will allow easy testing of specific CaMKII functions in various physiological and pathological situations, and may thus lead to new therapeutic avenues, including for stroke. ..
  8. CaMKII signaling in insulin secretion and response
    K Ulrich Bayer; Fiscal Year: 2007
    ..3) Test feasibility of methods to study function of specific CaMKII isoforms in beta cells and islets. [unreadable] [unreadable]..