Genomes and Genes
Gene Symbol: Calb1
Description: calbindin 1
Alias: CaBP28K, calbindin, D-28K, calbindin 1, 28 kD, calbindin D28, cerebellar Ca-binding protein, spot 35 protein, spot 35 protein, vitamin D-dependent calcium-binding protein, avian-type
- The concentrations of calcium buffering proteins in mammalian cochlear hair cellsCarole M Hackney
MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
J Neurosci 25:7867-75. 2005..We measured the concentrations of the four main calcium-buffering proteins (calbindin-D28k, calretinin, parvalbumin-alpha, and parvalbumin-beta) in rat cochlear hair cells in which Ca2+ signaling is ..
- Hypothyroid states mitigate the diabetes-induced reduction of calbindin D-28k, calretinin, and parvalbumin immunoreactivity in type 2 diabetic ratsSung Min Nam
Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151 742, South Korea
Neurochem Res 37:253-60. 2012In this study, we investigated the differences in calbindin D-28k (CB), calretinin, (CR) and parvalbumin (PV) immunoreactivity in the hippocampus of Zucker diabetic fatty (ZDF) rats and Zucker lean control (ZLC) rats...
- Calbindin-D-28K like immunoreactivity in superficial dorsal horn neurons and effects of sciatic chronic constriction injuryM J Stebbing
School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora 3083, Victoria, Australia
Neuroscience 324:330-43. 2016..Since the calcium-binding protein calbindin D-28K has been associated with excitatory neurons, we examined whether CCI altered the properties of neurons ..
- Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currentsGitte L Christensen
Department of Biomedical Sciences, University of Copenhagen, Nørre Allé 20, 2100, Copenhagen, Denmark
Diabetologia 58:1282-90. 2015..Bone morphogenetic protein 4 (BMP4) expression is increased in diabetic animals and BMP4 reduces glucose-stimulated insulin secretion (GSIS). Here, we investigate the molecular mechanism behind this inhibition...
- Time-dependent changes of calbindin D-28K and parvalbumin immunoreactivity in the hippocampus of rats with streptozotocin-induced type 1 diabetesSun Shin Yi
Department of Biomedical Laboratory Science, College of Biomedical Sciences, Soonchunhyang University, Asan 336 745, Korea
J Vet Sci 14:373-80. 2013..However, this number subsequently decreased over time. These results suggest that CB and PV expression is lowest 3 weeks after STZ administration, and these deficits lead to disturbances in calcium homeostasis. ..
- Estrogen deficiency-induced Ca balance impairment is associated with decrease in expression of epithelial Ca transport proteins in aged female ratsXiao Li Dong
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, People s Republic of China
Life Sci 96:26-32. 2014....
- Selegiline (deprenyl) decreases calbindin-D28k expression in cortical neurons of rats socially deprived during the post-weaning periodRodrigo Pascual
Laboratorio de Neurociencias, Escuela de Kinesiología, Facultad de Ciencias, Pontificia Universidad Catolica de Valparaiso, Chile
Int J Dev Neurosci 31:145-9. 2013..Since the main intracellular Ca(2+) buffering mechanism involves changes in the calcium-binding protein calbindin-D28k (CB), and that CB neuronal expression can increase in response to Ca(2+) transients, we hypothesized that ..
- Cytosolic Ca2+ buffersBeat Schwaller
Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
Cold Spring Harb Perspect Biol 2:a004051. 2010..Examples of Ca(2+) buffers include parvalbumins (α and β isoforms), calbindin-D9k, calbindin-D28k, and calretinin...
- The effect of different maternal deprivation paradigms on the expression of hippocampal glucocorticoid receptors, calretinin and calbindin-D28k in male and female adolescent ratsHongyu Xu
Department of Physiology, School of Basic Medical Sciences, Third Military Medical University, Chongqing, China
Neurochem Int 59:847-52. 2011..hippocampal expression of glucocorticoid receptors (GRs) and the calcium-binding proteins calretinin (CALR) and calbindin-D28k (CALB) in male and female rats that underwent different MD paradigms during the stress hyporesponsive ..
- Calretinin, parvalbumin and calbindin immunoreactive interneurons in perirhinal cortex and temporal area Te3V of the rat brain: qualitative and quantitative analysesFilip Barinka
Department of Anatomy, Charles University in Prague, 2nd Faculty of Medicine, U nemocnice 3, 128 00 Prague, Czech Republic
Brain Res 1436:68-80. 2012..We studied the general pattern of calretinin (CR), parvalbumin (PV) and calbindin (CB) immunoreactivity and its corrected relative optical density (cROD) as well as morphological features and ..
- Calbindin-D28k immunoreactivity in sympathetic ganglionic neurons during developmentPetr M Masliukov
Department of Normal Physiology, Yaroslavl State Medical Academy, Yaroslavl, Russia
Auton Neurosci 167:27-33. 2012..Finally, the changes in the size and percentages of CB-IR neurons were complete in rats at the first month of life, and in cats at the end of the second month...
- Calbindin controls release probability in ventral tegmental area dopamine neuronsPing Yue Pan
Department of Biochemistry, Weill Cornell Medical College, New York, NY, USA
Nat Neurosci 15:813-5. 2012..In ventral tegmental area neurons, this allows exocytosis to be efficiently controlled by a native fast calcium buffer, calbindin-D28k, maintaining a lower vesicular release probability compared with substantia nigra neurons.
- Effects of a high-sodium diet on renal tubule Ca2+ transporter and claudin expression in Wistar-Kyoto ratsMidori Sasaki Yatabe
Department of Pharmacology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960 1295, Japan
BMC Nephrol 13:160. 2012..This study examined alterations in the expressions of renal Ca2+ transporters, channels and claudins upon salt loading to better understand the mechanism of salt-induced urinary Ca2+ loss...
- Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segmentsS M Jenkins
Howard Hughes Medical Institute and Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
J Cell Biol 155:739-46. 2001....
- Influence of aging on the calbindin-D-28k immunoreactive positive dopaminergic neurons in the substantia nigra pars compacta of ratsHong Mei Liu
Department of Neurobiology and Anatomy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, 221002, China
Neurosci Lett 468:3-6. 2010We studied the relationship between aging and the vulnerability of substantia nigra pars compacta (SNc) calbindin-D-28k immunoreactive positive (CB+) dopaminergic (DA) neurons...
- Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometryCarey A Hobbs
Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, USA
Biochemistry 48:8603-14. 2009b>Calbindin-D28k is a calcium binding protein with six EF hand domains. Calbindin-D28k is unique in that it functions as both a calcium buffer and a sensor protein...
- Effects of thiazide on the expression of TRPV5, calbindin-D28K, and sodium transporters in hypercalciuric ratsHye Ryoun Jang
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
J Korean Med Sci 24:S161-9. 2009..We assessed the effects of hydrochlorothiazide (HCTZ) on the expression of TRPV5, calbindin-D(28K), and several sodium transporters in hypercalciuric rats...
- Spontaneous glutamate release controls NT-3-dependent development of hippocampal calbindin-D(28k) phenotype through activation of sodium channels ex vivoSimon Pieraut
INSERM U 583, 80 rue Augustin Fliche F34091 Montpellier, France
Eur J Neurosci 25:2629-39. 2007..At the same time, these neurons develop their calbindin-D(28k) phenotype through an activity-dependent NT-3 autocrine loop...
- The expression and implication of TRPV5, Calbindin-D28k and NCX1 in idiopathic hypercalciuriaShaogang Wang
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
J Huazhong Univ Sci Technolog Med Sci 28:580-3. 2008The expression of calcium epithelium TRPV5, alcium binding protein Calbindin-D28k and Na(+)/Ca(2+) exchanger NCX1 was detected in renal distal convoluted tubule, and their effects on urine calcium reabsorption and the possible pathogenic ..
- Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retinaDeb Kumar Mojumder
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Vis 14:1600-13. 2008..Two major EF-hand (E-helix-loop-F-helix-hand) calcium binding proteins in the retina, calretinin and calbindin-28 kDa, are important buffers of intracellular free Ca(2+) in neurons, and may also serve as Ca(2+)-dependent ..
- Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathwayHong Jun Wang
Department of Neurobiology, Xuzhou Medical College, Jiangsu Province, PR China
Eur J Pharmacol 595:7-12. 2008b>Calbindin-D28K is a calcium-binding protein in neuronal cytoplasm, which has the capability to protect neurons from degeneration...
- Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticusDawn S Carter
Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States
Epilepsy Res 79:213-23. 2008..One major regulator of Ca(2+) homeostasis is the neuronal calcium binding protein, calbindin-D28k that serves to buffer and transport Ca(2+) ions...
- Peptide binding proclivities of calcium loaded calbindin-D28kDavid R Kordys
Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA
FEBS Lett 581:4778-82. 2007b>Calbindin-D28k is known to function as a calcium-buffering protein in the cell. Moreover, recent evidence shows that it also plays a role as a sensor...
- Calcium-binding proteins as markers of layer-I projecting vs. deep layer-projecting thalamocortical neurons: a double-labeling analysis in the ratP Rubio-Garrido
Department of Anatomy and Neuroscience, Autonoma University School of Medicine, Avenida Arzobispo Morcillo s n, Madrid, E 28029, Spain
Neuroscience 149:242-50. 2007..a large part of the M-type cell populations in the thalamus and subsequently examined FB co-localization with calbindin or parvalbumin immunoreactivity in thalamic neuron somata...
- Increased calbindin-D28K immunoreactivity in rat cerebellar Purkinje cell with excitatory amino acids agonists is not dependent on protein synthesisR Vigot
Laboratoire de Physiologie de la Motricité, CNRS UMR 9923, Universite Pierre et Marie Curie, 75634, CHU Pitie Salpetriere, Paris, France
Arch Ital Biol 142:69-75. 2004The calcium binding protein Calbindin-D28K (CaBP) is abundantly expressed in cerebellar Purkinje cells and show increased immunoreactivity (CaBP-IR) when challenged with glutamate or an analog agonist for the ionotropic glutamate ..
- Cloning and analysis of calbindin-D28K cDNA and its expression in the central nervous systemN Lomri
INSERM U 120, alliée CNRS, Le Vesinet, France
Gene 80:87-98. 1989The vitamin D-dependent calcium-binding protein (CaBP), calbindin-D28K (CaBP28K), is present in the central nervous system (CNS), the sensory system, and kidneys of mammals and birds...
- Rat brain calbindin D28: six domain structure and extensive amino acid homology with chicken calbindin D28W Hunziker
Central Research Units, Hoffmann La Roche and Company, Ltd, Basle, Switzerland
Mol Endocrinol 2:465-73. 1988b>Calbindin D28 cDNA clones were isolated from a rat brain library using a chicken intestinal Calbindin D28 cDNA probe...
- Molecular cloning of cDNA to mRNA for a cerebellar spot 35 proteinT Yamakuni
J Neurochem 48:1590-6. 1987The nucleotide sequence of mRNA for rat cerebellar spot 35 protein, a Ca-binding protein, was determined from recombinant complementary DNA (cDNA) clones...
- Expression in Escherichia coli of full-length and mutant rat brain calbindin D28. Comparison with the purified native proteinM D Gross
Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, 55905
J Biol Chem 263:14426-32. 1988Studies of vitamin D-dependent 28-kilodalton calcium binding protein (calbindin D28) have been hindered by difficulties in purifying large amounts of the protein...
- Nucleotide sequence of cDNA to mRNA for a cerebellar Ca-binding protein, spot 35 proteinT Yamakuni
Nucleic Acids Res 14:6768. 1986
- Changes in calcium-binding protein expression in the auditory brainstem nuclei of the jaundiced Gunn ratRobert F Spencer
Department of Otolaryngology Head and Neck Surgery, School of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
Hear Res 171:129-141. 2002..The expression of the calcium-binding proteins, calbindin-D28k and parvalbumin, in the brainstem auditory pathway of homozygous recessive jaundiced (jj) Gunn rats was ..
- Immunohistochemical localization of calcium-binding proteins in the brainstem vestibular nuclei of the jaundiced Gunn ratWayne T Shaia
Department of Otolaryngology Head and Neck Surgery, School of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University Health System, Richmond 23298 0599, USA
Hear Res 173:82-90. 2002..The expression of the calcium-binding proteins calbindin-D28k and parvalbumin in the brainstem vestibular pathways and cerebellum of homozygous recessive jaundiced (jj) ..
- Synaptic connections of distinct interneuronal subpopulations in the rat basolateral amygdalar nucleusJay F Muller
Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia 29208, USA
J Comp Neurol 456:217-36. 2003..immunofluorescence experiments revealed that antibodies to vasoactive intestinal peptide (VIP) and calbindin-D28K (CB) labeled two separate interneuronal subpopulations in the ABL...
- Calbindin D28K immunoreactive neurons in vomeronasal organ and their projections to the accessory olfactory bulb in the ratChangping Jia
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
Brain Res 977:261-9. 2003..In this study, we examined the expression of calbindin D28k (CB) in the rat VNO and AOB...
- Light microscopic study of GluR1 and calbindin expression in interneurons of neocortical microgyral malformationsV N Kharazia
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, 300 Pasteur Drive, M016, Stanford, CA 94305, USA
Neuroscience 120:207-18. 2003..alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit and the calcium-binding protein, calbindin (CB)...
- The classical and a non-classical pathways associated with NF-kappaB are involved in estrogen-mediated regulation of calbindin-D9k gene in rat pituitary cellsGeun Shik Lee
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361 763, Republic of Korea
Mol Cell Endocrinol 277:42-50. 2007b>Calbindin-D9k (CaBP-9k) is a high affinity calcium binding protein that is highly expressed in the duodenum, kidney, uterus, and pituitary glands...
- Overexpression of calbindin D(28k) in dentate gyrus granule cells alters mossy fiber presynaptic function and impairs hippocampal-dependent memoryT C Dumas
Department of Biological Sciences, Stanford University, Stanford, California, USA
Hippocampus 14:701-9. 2004..We used herpes simplex amplicons to overexpress calbindin D(28k) (CaBP) selectively in dentate gyrus (DG) granule cells...
- Changes in structure and stability of calbindin-D(28K) upon calcium bindingSergei Yu Venyaminov
Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Anal Biochem 334:97-105. 2004b>Calbindin-D(28K) is a biologically important protein required for normal neural function and for the transport of calcium in epithelial cells of the intestine and kidney...
- Endogenous Ca2+ buffer concentration and Ca2+ microdomains in hippocampal neuronsAndreas Muller
Department of Neurosurgery, University Clinic Bonn, D 53105 Bonn, Germany
J Neurosci 25:558-65. 2005..In this study, we investigate the intracellular concentration of the widely expressed Ca2+-binding protein calbindin-D28k in adult hippocampal slices using patch-clamp recordings and immunohistochemistry...
- Calbindin-D28k (CaBP28k) identification and regulation by 1,25-dihydroxyvitamin D3 in human choriocarcinoma cell line JEG-3Louiza Belkacemi
Laboratoire de Physiologie Materno Foetale, Departement des Sciences Biologiques, Universite du Quebec a Montreal, C P 8888, Succursale Centre Ville, Montreal, Que, Canada H3C 3P8
Mol Cell Endocrinol 236:31-41. 2005b>Calbindin-D28k (CaBP28k) is a cytosolic calcium (Ca2+)-binding protein expressed in tissues such as intestine, kidneys and placenta. This protein is thought to be involved in Ca2+ homeostasis...
- Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowthJu Hee Kim
Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, Seoul, Korea
FASEB J 20:109-11. 2006Excitatory stimuli are known to be a potent regulator for induction of neuronal differentiation. Calbindin-D28K buffers intracellular Ca2+ and modifies synaptic functions in neurons...
- Calbindin-D28k decreases L-type calcium channel activity and modulates intracellular calcium homeostasis in response to K+ depolarization in a rat beta cell line RINr1046-38David Lee
Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
Cell Calcium 39:475-485. 2006b>Calbindin-D(28k), acts as a modulator of depolarization induced calcium transients in the pancreatic beta cell. However, specific mechanisms have not been defined...
- Calbindin is predominantly expressed in nitrergic neurons in rat esophagusHirofumi Kuramoto
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto 606 8585, Japan
Neurosci Lett 401:174-7. 2006We used immunohistochemistry to investigate the colocalization pattern of calbindin D28k (Calb) with nitric oxide and acetylcholine in myenteric neurons in the rat esophagus and compared it to that in the ileum or distal colon...
- Chronic hypoxia alters calbindin D-28k immunoreactivity in lingual and laryngeal taste buds in the ratT Yoshida
Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Japan
Histol Histopathol 21:1271-6. 2006The distribution and abundance of the calcium binding protein, calbindin D-28k (CB) immunoreactivity in the taste buds of the circumvallate papillae and larynx were compared between normoxic and chronically hypoxic rats (10% O2 for 8 ..
- Brain calbindin-D28k and an Mr 29,000 calcium binding protein in cerebellum are different but related proteins: evidence obtained from sequence analysis by tandem mass spectrometryC Gabrielides
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103
Biochemistry 30:656-62. 1991A calcium binding protein of Mr 29,000 which cross-reacts with antibodies raised against chick calbindin-D28k was previously reported to be present in rat cerebellum [Pochet, R., Parmentier, M., Lawson, D. E. M., & Pasteels, J. L...
- Tri-Institutional Training Program in Chemical BiologyTimothy Ryan; Fiscal Year: 2008..The goal of this project is to help meet the future needs defined in terms of these challenging research problems by training students simultaneously in these two different research disciplines. [unreadable] [unreadable] [unreadable]..