Calb1

Summary

Gene Symbol: Calb1
Description: calbindin 1
Alias: CaBP28K, calbindin, D-28K, calbindin 1, 28 kD, calbindin D28, cerebellar Ca-binding protein, spot 35 protein, spot 35 protein, vitamin D-dependent calcium-binding protein, avian-type
Species: rat

Top Publications

  1. ncbi The concentrations of calcium buffering proteins in mammalian cochlear hair cells
    Carole M Hackney
    MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
    J Neurosci 25:7867-75. 2005
  2. doi Hypothyroid states mitigate the diabetes-induced reduction of calbindin D-28k, calretinin, and parvalbumin immunoreactivity in type 2 diabetic rats
    Sung Min Nam
    Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151 742, South Korea
    Neurochem Res 37:253-60. 2012
  3. doi Calbindin-D-28K like immunoreactivity in superficial dorsal horn neurons and effects of sciatic chronic constriction injury
    M J Stebbing
    School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora 3083, Victoria, Australia
    Neuroscience 324:330-43. 2016
  4. doi Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents
    Gitte L Christensen
    Department of Biomedical Sciences, University of Copenhagen, Nørre Allé 20, 2100, Copenhagen, Denmark
    Diabetologia 58:1282-90. 2015
  5. pmc Time-dependent changes of calbindin D-28K and parvalbumin immunoreactivity in the hippocampus of rats with streptozotocin-induced type 1 diabetes
    Sun Shin Yi
    Department of Biomedical Laboratory Science, College of Biomedical Sciences, Soonchunhyang University, Asan 336 745, Korea
    J Vet Sci 14:373-80. 2013
  6. doi Estrogen deficiency-induced Ca balance impairment is associated with decrease in expression of epithelial Ca transport proteins in aged female rats
    Xiao Li Dong
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, People s Republic of China
    Life Sci 96:26-32. 2014
  7. doi Selegiline (deprenyl) decreases calbindin-D28k expression in cortical neurons of rats socially deprived during the post-weaning period
    Rodrigo Pascual
    Laboratorio de Neurociencias, Escuela de Kinesiología, Facultad de Ciencias, Pontificia Universidad Catolica de Valparaiso, Chile
    Int J Dev Neurosci 31:145-9. 2013
  8. pmc Cytosolic Ca2+ buffers
    Beat Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
    Cold Spring Harb Perspect Biol 2:a004051. 2010
  9. doi The effect of different maternal deprivation paradigms on the expression of hippocampal glucocorticoid receptors, calretinin and calbindin-D28k in male and female adolescent rats
    Hongyu Xu
    Department of Physiology, School of Basic Medical Sciences, Third Military Medical University, Chongqing, China
    Neurochem Int 59:847-52. 2011
  10. doi Calretinin, parvalbumin and calbindin immunoreactive interneurons in perirhinal cortex and temporal area Te3V of the rat brain: qualitative and quantitative analyses
    Filip Barinka
    Department of Anatomy, Charles University in Prague, 2nd Faculty of Medicine, U nemocnice 3, 128 00 Prague, Czech Republic
    Brain Res 1436:68-80. 2012

Research Grants

Scientific Experts

  • Sun Shin Yi
  • TIMOTHY AIDAN RYAN
  • B Schwaller
  • S M Jenkins
  • Rodrigo Pascual
  • Filip Barinka
  • Petr M Masliukov
  • Midori Sasaki Yatabe
  • Sergei Yu Venyaminov
  • Theodore C Dumas
  • Hirofumi Kuramoto
  • Deb Kumar Mojumder
  • Shao Gang Wang
  • M J Stebbing
  • Gitte L Christensen
  • Xiao Li Dong
  • Sung Min Nam
  • Ping Yue Pan
  • Hongyu Xu
  • Hong Mei Liu
  • Dian Shuai Gao
  • Hye Ryoun Jang
  • Carey A Hobbs
  • Dawn S Carter
  • John Cavanagh
  • Benjamin G Bobay
  • Richele J Thompson
  • Hong Jun Wang
  • Wayne T Shaia
  • Robert F Spencer
  • P Rubio-Garrido
  • Simon Pieraut
  • Geun Shik Lee
  • David R Kordys
  • T Yoshida
  • Ju Hee Kim
  • David Lee
  • Carole M Hackney
  • Louiza Belkacemi
  • Andreas Muller
  • R Vigot
  • P A Smith
  • V N Kharazia
  • Changping Jia
  • Jay F Muller
  • S Balasubramanyan
  • Lena Eliasson
  • Klaus S Frederiksen
  • Maria L B Jacobsen
  • Nils Billestrup
  • Inês G Mollet
  • Michael Meyer
  • Anna Wendt
  • Christine Bruun
  • Josefine Friberg
  • Steven M Shapiro
  • Aristides Sismanis
  • Man Sau Wong
  • Yan Zhang
  • Yeo Sung Yoon
  • In Koo Hwang
  • Dae Young Yoo
  • Je Kyung Seong
  • Yo Na Kim
  • Woosuk Kim
  • Ming Liang
  • Xuesi Zhang
  • Wei Gao
  • Zhian Hu
  • Wendong Hu
  • Xiaosheng He
  • Tao Chen
  • Hui Miao
  • Yu Sun
  • Xia Du
  • Hong Hua Yuan
  • Hong Li Yu
  • Jin Gao
  • Cheng Hua Xiao
  • Yun Kyu Oh
  • Nam Ju Heo
  • Un Sil Jeon
  • Leesa J Deterding
  • Kwon Wook Joo
  • Lalith Perera
  • Hyo Sang Kim
  • Sejoong Kim
  • Jin Suk Han
  • Søren Nielsen
  • Kenneth B Tomer

Detail Information

Publications46

  1. ncbi The concentrations of calcium buffering proteins in mammalian cochlear hair cells
    Carole M Hackney
    MacKay Institute of Communication and Neuroscience, School of Life Sciences, Keele University, Keele, Staffordshire ST5 5BG, United Kingdom
    J Neurosci 25:7867-75. 2005
    ..We measured the concentrations of the four main calcium-buffering proteins (calbindin-D28k, calretinin, parvalbumin-alpha, and parvalbumin-beta) in rat cochlear hair cells in which Ca2+ signaling is ..
  2. doi Hypothyroid states mitigate the diabetes-induced reduction of calbindin D-28k, calretinin, and parvalbumin immunoreactivity in type 2 diabetic rats
    Sung Min Nam
    Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151 742, South Korea
    Neurochem Res 37:253-60. 2012
    In this study, we investigated the differences in calbindin D-28k (CB), calretinin, (CR) and parvalbumin (PV) immunoreactivity in the hippocampus of Zucker diabetic fatty (ZDF) rats and Zucker lean control (ZLC) rats...
  3. doi Calbindin-D-28K like immunoreactivity in superficial dorsal horn neurons and effects of sciatic chronic constriction injury
    M J Stebbing
    School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora 3083, Victoria, Australia
    Neuroscience 324:330-43. 2016
    ..Since the calcium-binding protein calbindin D-28K has been associated with excitatory neurons, we examined whether CCI altered the properties of neurons ..
  4. doi Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents
    Gitte L Christensen
    Department of Biomedical Sciences, University of Copenhagen, Nørre Allé 20, 2100, Copenhagen, Denmark
    Diabetologia 58:1282-90. 2015
    ..Bone morphogenetic protein 4 (BMP4) expression is increased in diabetic animals and BMP4 reduces glucose-stimulated insulin secretion (GSIS). Here, we investigate the molecular mechanism behind this inhibition...
  5. pmc Time-dependent changes of calbindin D-28K and parvalbumin immunoreactivity in the hippocampus of rats with streptozotocin-induced type 1 diabetes
    Sun Shin Yi
    Department of Biomedical Laboratory Science, College of Biomedical Sciences, Soonchunhyang University, Asan 336 745, Korea
    J Vet Sci 14:373-80. 2013
    ..However, this number subsequently decreased over time. These results suggest that CB and PV expression is lowest 3 weeks after STZ administration, and these deficits lead to disturbances in calcium homeostasis. ..
  6. doi Estrogen deficiency-induced Ca balance impairment is associated with decrease in expression of epithelial Ca transport proteins in aged female rats
    Xiao Li Dong
    Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, People s Republic of China
    Life Sci 96:26-32. 2014
    ....
  7. doi Selegiline (deprenyl) decreases calbindin-D28k expression in cortical neurons of rats socially deprived during the post-weaning period
    Rodrigo Pascual
    Laboratorio de Neurociencias, Escuela de Kinesiología, Facultad de Ciencias, Pontificia Universidad Catolica de Valparaiso, Chile
    Int J Dev Neurosci 31:145-9. 2013
    ..Since the main intracellular Ca(2+) buffering mechanism involves changes in the calcium-binding protein calbindin-D28k (CB), and that CB neuronal expression can increase in response to Ca(2+) transients, we hypothesized that ..
  8. pmc Cytosolic Ca2+ buffers
    Beat Schwaller
    Unit of Anatomy, Department of Medicine, University of Fribourg, Route Albert Gockel 1, CH 1700 Fribourg, Switzerland
    Cold Spring Harb Perspect Biol 2:a004051. 2010
    ..Examples of Ca(2+) buffers include parvalbumins (α and β isoforms), calbindin-D9k, calbindin-D28k, and calretinin...
  9. doi The effect of different maternal deprivation paradigms on the expression of hippocampal glucocorticoid receptors, calretinin and calbindin-D28k in male and female adolescent rats
    Hongyu Xu
    Department of Physiology, School of Basic Medical Sciences, Third Military Medical University, Chongqing, China
    Neurochem Int 59:847-52. 2011
    ..hippocampal expression of glucocorticoid receptors (GRs) and the calcium-binding proteins calretinin (CALR) and calbindin-D28k (CALB) in male and female rats that underwent different MD paradigms during the stress hyporesponsive ..
  10. doi Calretinin, parvalbumin and calbindin immunoreactive interneurons in perirhinal cortex and temporal area Te3V of the rat brain: qualitative and quantitative analyses
    Filip Barinka
    Department of Anatomy, Charles University in Prague, 2nd Faculty of Medicine, U nemocnice 3, 128 00 Prague, Czech Republic
    Brain Res 1436:68-80. 2012
    ..We studied the general pattern of calretinin (CR), parvalbumin (PV) and calbindin (CB) immunoreactivity and its corrected relative optical density (cROD) as well as morphological features and ..
  11. doi Calbindin-D28k immunoreactivity in sympathetic ganglionic neurons during development
    Petr M Masliukov
    Department of Normal Physiology, Yaroslavl State Medical Academy, Yaroslavl, Russia
    Auton Neurosci 167:27-33. 2012
    ..Finally, the changes in the size and percentages of CB-IR neurons were complete in rats at the first month of life, and in cats at the end of the second month...
  12. pmc Calbindin controls release probability in ventral tegmental area dopamine neurons
    Ping Yue Pan
    Department of Biochemistry, Weill Cornell Medical College, New York, NY, USA
    Nat Neurosci 15:813-5. 2012
    ..In ventral tegmental area neurons, this allows exocytosis to be efficiently controlled by a native fast calcium buffer, calbindin-D28k, maintaining a lower vesicular release probability compared with substantia nigra neurons.
  13. pmc Effects of a high-sodium diet on renal tubule Ca2+ transporter and claudin expression in Wistar-Kyoto rats
    Midori Sasaki Yatabe
    Department of Pharmacology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960 1295, Japan
    BMC Nephrol 13:160. 2012
    ..This study examined alterations in the expressions of renal Ca2+ transporters, channels and claudins upon salt loading to better understand the mechanism of salt-induced urinary Ca2+ loss...
  14. pmc Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments
    S M Jenkins
    Howard Hughes Medical Institute and Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 155:739-46. 2001
    ....
  15. doi Influence of aging on the calbindin-D-28k immunoreactive positive dopaminergic neurons in the substantia nigra pars compacta of rats
    Hong Mei Liu
    Department of Neurobiology and Anatomy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, 221002, China
    Neurosci Lett 468:3-6. 2010
    We studied the relationship between aging and the vulnerability of substantia nigra pars compacta (SNc) calbindin-D-28k immunoreactive positive (CB+) dopaminergic (DA) neurons...
  16. pmc Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry
    Carey A Hobbs
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, USA
    Biochemistry 48:8603-14. 2009
    b>Calbindin-D28k is a calcium binding protein with six EF hand domains. Calbindin-D28k is unique in that it functions as both a calcium buffer and a sensor protein...
  17. pmc Effects of thiazide on the expression of TRPV5, calbindin-D28K, and sodium transporters in hypercalciuric rats
    Hye Ryoun Jang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    J Korean Med Sci 24:S161-9. 2009
    ..We assessed the effects of hydrochlorothiazide (HCTZ) on the expression of TRPV5, calbindin-D(28K), and several sodium transporters in hypercalciuric rats...
  18. ncbi Spontaneous glutamate release controls NT-3-dependent development of hippocampal calbindin-D(28k) phenotype through activation of sodium channels ex vivo
    Simon Pieraut
    INSERM U 583, 80 rue Augustin Fliche F34091 Montpellier, France
    Eur J Neurosci 25:2629-39. 2007
    ..At the same time, these neurons develop their calbindin-D(28k) phenotype through an activity-dependent NT-3 autocrine loop...
  19. doi The expression and implication of TRPV5, Calbindin-D28k and NCX1 in idiopathic hypercalciuria
    Shaogang Wang
    Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 28:580-3. 2008
    The expression of calcium epithelium TRPV5, alcium binding protein Calbindin-D28k and Na(+)/Ca(2+) exchanger NCX1 was detected in renal distal convoluted tubule, and their effects on urine calcium reabsorption and the possible pathogenic ..
  20. pmc Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina
    Deb Kumar Mojumder
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Vis 14:1600-13. 2008
    ..Two major EF-hand (E-helix-loop-F-helix-hand) calcium binding proteins in the retina, calretinin and calbindin-28 kDa, are important buffers of intracellular free Ca(2+) in neurons, and may also serve as Ca(2+)-dependent ..
  21. doi Calbindin-D28K expression induced by glial cell line-derived neurotrophic factor in substantia nigra neurons dependent on PI3K/Akt/NF-kappaB signaling pathway
    Hong Jun Wang
    Department of Neurobiology, Xuzhou Medical College, Jiangsu Province, PR China
    Eur J Pharmacol 595:7-12. 2008
    b>Calbindin-D28K is a calcium-binding protein in neuronal cytoplasm, which has the capability to protect neurons from degeneration...
  22. pmc Long-term decrease in calbindin-D28K expression in the hippocampus of epileptic rats following pilocarpine-induced status epilepticus
    Dawn S Carter
    Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, United States
    Epilepsy Res 79:213-23. 2008
    ..One major regulator of Ca(2+) homeostasis is the neuronal calcium binding protein, calbindin-D28k that serves to buffer and transport Ca(2+) ions...
  23. ncbi Peptide binding proclivities of calcium loaded calbindin-D28k
    David R Kordys
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA
    FEBS Lett 581:4778-82. 2007
    b>Calbindin-D28k is known to function as a calcium-buffering protein in the cell. Moreover, recent evidence shows that it also plays a role as a sensor...
  24. ncbi Calcium-binding proteins as markers of layer-I projecting vs. deep layer-projecting thalamocortical neurons: a double-labeling analysis in the rat
    P Rubio-Garrido
    Department of Anatomy and Neuroscience, Autonoma University School of Medicine, Avenida Arzobispo Morcillo s n, Madrid, E 28029, Spain
    Neuroscience 149:242-50. 2007
    ..a large part of the M-type cell populations in the thalamus and subsequently examined FB co-localization with calbindin or parvalbumin immunoreactivity in thalamic neuron somata...
  25. ncbi Increased calbindin-D28K immunoreactivity in rat cerebellar Purkinje cell with excitatory amino acids agonists is not dependent on protein synthesis
    R Vigot
    Laboratoire de Physiologie de la Motricité, CNRS UMR 9923, Universite Pierre et Marie Curie, 75634, CHU Pitie Salpetriere, Paris, France
    Arch Ital Biol 142:69-75. 2004
    The calcium binding protein Calbindin-D28K (CaBP) is abundantly expressed in cerebellar Purkinje cells and show increased immunoreactivity (CaBP-IR) when challenged with glutamate or an analog agonist for the ionotropic glutamate ..
  26. ncbi Cloning and analysis of calbindin-D28K cDNA and its expression in the central nervous system
    N Lomri
    INSERM U 120, alliée CNRS, Le Vesinet, France
    Gene 80:87-98. 1989
    The vitamin D-dependent calcium-binding protein (CaBP), calbindin-D28K (CaBP28K), is present in the central nervous system (CNS), the sensory system, and kidneys of mammals and birds...
  27. ncbi Rat brain calbindin D28: six domain structure and extensive amino acid homology with chicken calbindin D28
    W Hunziker
    Central Research Units, Hoffmann La Roche and Company, Ltd, Basle, Switzerland
    Mol Endocrinol 2:465-73. 1988
    b>Calbindin D28 cDNA clones were isolated from a rat brain library using a chicken intestinal Calbindin D28 cDNA probe...
  28. ncbi Molecular cloning of cDNA to mRNA for a cerebellar spot 35 protein
    T Yamakuni
    J Neurochem 48:1590-6. 1987
    The nucleotide sequence of mRNA for rat cerebellar spot 35 protein, a Ca-binding protein, was determined from recombinant complementary DNA (cDNA) clones...
  29. ncbi Expression in Escherichia coli of full-length and mutant rat brain calbindin D28. Comparison with the purified native protein
    M D Gross
    Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota, 55905
    J Biol Chem 263:14426-32. 1988
    Studies of vitamin D-dependent 28-kilodalton calcium binding protein (calbindin D28) have been hindered by difficulties in purifying large amounts of the protein...
  30. pmc Nucleotide sequence of cDNA to mRNA for a cerebellar Ca-binding protein, spot 35 protein
    T Yamakuni
    Nucleic Acids Res 14:6768. 1986
  31. ncbi Changes in calcium-binding protein expression in the auditory brainstem nuclei of the jaundiced Gunn rat
    Robert F Spencer
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
    Hear Res 171:129-141. 2002
    ..The expression of the calcium-binding proteins, calbindin-D28k and parvalbumin, in the brainstem auditory pathway of homozygous recessive jaundiced (jj) Gunn rats was ..
  32. ncbi Immunohistochemical localization of calcium-binding proteins in the brainstem vestibular nuclei of the jaundiced Gunn rat
    Wayne T Shaia
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University Health System, Richmond 23298 0599, USA
    Hear Res 173:82-90. 2002
    ..The expression of the calcium-binding proteins calbindin-D28k and parvalbumin in the brainstem vestibular pathways and cerebellum of homozygous recessive jaundiced (jj) ..
  33. ncbi Synaptic connections of distinct interneuronal subpopulations in the rat basolateral amygdalar nucleus
    Jay F Muller
    Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia 29208, USA
    J Comp Neurol 456:217-36. 2003
    ..immunofluorescence experiments revealed that antibodies to vasoactive intestinal peptide (VIP) and calbindin-D28K (CB) labeled two separate interneuronal subpopulations in the ABL...
  34. ncbi Calbindin D28K immunoreactive neurons in vomeronasal organ and their projections to the accessory olfactory bulb in the rat
    Changping Jia
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Brain Res 977:261-9. 2003
    ..In this study, we examined the expression of calbindin D28k (CB) in the rat VNO and AOB...
  35. ncbi Light microscopic study of GluR1 and calbindin expression in interneurons of neocortical microgyral malformations
    V N Kharazia
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, 300 Pasteur Drive, M016, Stanford, CA 94305, USA
    Neuroscience 120:207-18. 2003
    ..alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit and the calcium-binding protein, calbindin (CB)...
  36. ncbi The classical and a non-classical pathways associated with NF-kappaB are involved in estrogen-mediated regulation of calbindin-D9k gene in rat pituitary cells
    Geun Shik Lee
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361 763, Republic of Korea
    Mol Cell Endocrinol 277:42-50. 2007
    b>Calbindin-D9k (CaBP-9k) is a high affinity calcium binding protein that is highly expressed in the duodenum, kidney, uterus, and pituitary glands...
  37. ncbi Overexpression of calbindin D(28k) in dentate gyrus granule cells alters mossy fiber presynaptic function and impairs hippocampal-dependent memory
    T C Dumas
    Department of Biological Sciences, Stanford University, Stanford, California, USA
    Hippocampus 14:701-9. 2004
    ..We used herpes simplex amplicons to overexpress calbindin D(28k) (CaBP) selectively in dentate gyrus (DG) granule cells...
  38. ncbi Changes in structure and stability of calbindin-D(28K) upon calcium binding
    Sergei Yu Venyaminov
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Anal Biochem 334:97-105. 2004
    b>Calbindin-D(28K) is a biologically important protein required for normal neural function and for the transport of calcium in epithelial cells of the intestine and kidney...
  39. ncbi Endogenous Ca2+ buffer concentration and Ca2+ microdomains in hippocampal neurons
    Andreas Muller
    Department of Neurosurgery, University Clinic Bonn, D 53105 Bonn, Germany
    J Neurosci 25:558-65. 2005
    ..In this study, we investigate the intracellular concentration of the widely expressed Ca2+-binding protein calbindin-D28k in adult hippocampal slices using patch-clamp recordings and immunohistochemistry...
  40. ncbi Calbindin-D28k (CaBP28k) identification and regulation by 1,25-dihydroxyvitamin D3 in human choriocarcinoma cell line JEG-3
    Louiza Belkacemi
    Laboratoire de Physiologie Materno Foetale, Departement des Sciences Biologiques, Universite du Quebec a Montreal, C P 8888, Succursale Centre Ville, Montreal, Que, Canada H3C 3P8
    Mol Cell Endocrinol 236:31-41. 2005
    b>Calbindin-D28k (CaBP28k) is a cytosolic calcium (Ca2+)-binding protein expressed in tissues such as intestine, kidneys and placenta. This protein is thought to be involved in Ca2+ homeostasis...
  41. ncbi Overexpression of calbindin-D28K in hippocampal progenitor cells increases neuronal differentiation and neurite outgrowth
    Ju Hee Kim
    Department of Biochemistry and Molecular Biology, Hanyang University College of Medicine, Seoul, Korea
    FASEB J 20:109-11. 2006
    Excitatory stimuli are known to be a potent regulator for induction of neuronal differentiation. Calbindin-D28K buffers intracellular Ca2+ and modifies synaptic functions in neurons...
  42. ncbi Calbindin-D28k decreases L-type calcium channel activity and modulates intracellular calcium homeostasis in response to K+ depolarization in a rat beta cell line RINr1046-38
    David Lee
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    Cell Calcium 39:475-485. 2006
    b>Calbindin-D(28k), acts as a modulator of depolarization induced calcium transients in the pancreatic beta cell. However, specific mechanisms have not been defined...
  43. ncbi Calbindin is predominantly expressed in nitrergic neurons in rat esophagus
    Hirofumi Kuramoto
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto 606 8585, Japan
    Neurosci Lett 401:174-7. 2006
    We used immunohistochemistry to investigate the colocalization pattern of calbindin D28k (Calb) with nitric oxide and acetylcholine in myenteric neurons in the rat esophagus and compared it to that in the ileum or distal colon...
  44. ncbi Chronic hypoxia alters calbindin D-28k immunoreactivity in lingual and laryngeal taste buds in the rat
    T Yoshida
    Department of Otorhinolaryngology, Yokohama City University School of Medicine, Yokohama, Japan
    Histol Histopathol 21:1271-6. 2006
    The distribution and abundance of the calcium binding protein, calbindin D-28k (CB) immunoreactivity in the taste buds of the circumvallate papillae and larynx were compared between normoxic and chronically hypoxic rats (10% O2 for 8 ..
  45. ncbi Brain calbindin-D28k and an Mr 29,000 calcium binding protein in cerebellum are different but related proteins: evidence obtained from sequence analysis by tandem mass spectrometry
    C Gabrielides
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103
    Biochemistry 30:656-62. 1991
    A calcium binding protein of Mr 29,000 which cross-reacts with antibodies raised against chick calbindin-D28k was previously reported to be present in rat cerebellum [Pochet, R., Parmentier, M., Lawson, D. E. M., & Pasteels, J. L...

Research Grants1

  1. Tri-Institutional Training Program in Chemical Biology
    Timothy Ryan; Fiscal Year: 2008
    ..The goal of this project is to help meet the future needs defined in terms of these challenging research problems by training students simultaneously in these two different research disciplines. [unreadable] [unreadable] [unreadable]..