Cacna1b

Summary

Gene Symbol: Cacna1b
Description: calcium voltage-gated channel subunit alpha1 B
Alias: BIII, voltage-dependent N-type calcium channel subunit alpha-1B, brain calcium channel III, calcium channel, L type, alpha-1 polypeptide, calcium channel, voltage-dependent, N type, alpha 1B subunit, voltage gated N-type calcium channel Ca(v)2.2, voltage-gated calcium channel subunit alpha Cav2.2
Species: rat

Top Publications

  1. ncbi Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties
    Jérôme Leroy
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:6984-96. 2005
  2. ncbi Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit
    M Pragnell
    Howard Hughes Medical Institute, Department of Physiology, University of Iowa College of Medicine, Iowa City 52242
    Nature 368:67-70. 1994
  3. pmc Synaptic targeting of N-type calcium channels in hippocampal neurons
    Anton Maximov
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    J Neurosci 22:6939-52. 2002
  4. pmc Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation
    Meng Hua Zhou
    From the Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030
    J Biol Chem 290:30616-23. 2015
  5. doi Distribution of voltage-dependent and intracellular Ca2+ channels in submucosal neurons from rat distal colon
    Matthias Rehn
    Institute for Veterinary Physiology and Biochemistry, Justus Liebig University, Giessen, Germany
    Cell Tissue Res 353:355-66. 2013
  6. doi Gβ₂ mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons
    Juan M Hernández-Castellanos
    Department of Physiology, School of Medicine, Universidad Nacional Autonoma de Mexico UNAM, Apartado Postal 70250, C P 04510 México, D F, Mexico
    Biochem Biophys Res Commun 445:250-4. 2014
  7. doi CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation
    María A Gandini
    Department of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute, CINVESTAV IPN, Avenida IPN 2508, Colonia Zacatenco, Mexico DF, 07360, Mexico
    Pflugers Arch 466:2113-26. 2014
  8. ncbi Involvement of TRPM2 and L-type Ca²⁺ channels in Ca²⁺ entry and cell death induced by hydrogen peroxide in rat β-cell line RIN-5F
    Masakazu Ishii
    Department of Pharmacology, Toxicology and Therapeutics, Division of Physiology and Pathology, Showa University School of Pharmacy
    J Toxicol Sci 39:199-209. 2014
  9. pmc Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits
    John S Cassidy
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 111:8979-84. 2014
  10. pmc The upregulation of α2δ-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons
    Marianna D'Arco
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 35:5891-903. 2015

Research Grants

  1. DOPAMINE AND RETINAL ADAPTATION
    Paul Witkovsky; Fiscal Year: 2001

Scientific Experts

  • Elizabeth M Fitzgerald
  • R J Lewis
  • Xin Su
  • William A Catterall
  • P Witkovsky
  • PROSPER N'GOUEMO
  • Sareh Asadi
  • Jérôme Leroy
  • Nicole Martin-Moutot
  • Jonathan N Davies
  • Rajesh Khanna
  • Joel M Brittain
  • Gerald W Zamponi
  • John S Cassidy
  • Annette C Dolphin
  • Oscar Vivas
  • David E Garcia
  • Isabel Arenas
  • Jesica Raingo
  • Christophe Altier
  • Elise F Stanley
  • Lele Song
  • Meng Hua Zhou
  • Eduardo Javier López Soto
  • Marianna D'Arco
  • Ricardo Felix
  • Masakazu Ishii
  • María A Gandini
  • Juan M Hernández-Castellanos
  • Andrew J Castiglioni
  • Diane Lipscombe
  • David Elías-Viñas
  • Matthias Rehn
  • Meizan Lai
  • Laurent Ferron
  • Giovanna Bucci
  • Dominic Waithe
  • Yuying Wang
  • Xuan Huang
  • Hugo W Tedford
  • Santiago Rebolledo-Antunez
  • Alexandra E Kisilevsky
  • A G Miriam Leenders
  • Francois Maingret
  • Qi Li
  • Yong Sook Goo
  • Hongyu Fang
  • Henrike Berkefeld
  • Z Lin
  • Dongjun Li
  • Yuan Chen
  • S I Nudler
  • Ji fang Zhang
  • Fushun Wang
  • J Q Pan
  • Anita Scheuber
  • Ryan W Richman
  • Thomas J Bell
  • Isabelle Latour
  • D Lipscombe
  • Agustina Cabral
  • Daniel Castrogiovanni
  • Mario Perello
  • Alexis Bavencoffe
  • Silvia Rodriguez
  • Sarah Etheridge
  • Owen T Jones
  • Italo A Espinoza-Fuenzalida
  • Valentina Martínez Damonte
  • Maria Alejandra Gandini
  • Wojciech Margas
  • Francina Agosti
  • Hui Lin Pan
  • Emilio Roman Mustafa
  • Yasuo Mori
  • Julieta Garduño
  • Daniel R Henríquez
  • Alejandro Sandoval
  • Ken Mackie
  • Anton Maximov
  • Christian Gonzalez-Billault
  • Lizbeth Grimaldo
  • Shunichi Shimizu
  • Wendy S Pratt
  • Tamio Hagiwara
  • Ivan Kadurin
  • Lizbeth De la Cruz
  • Hector Castro
  • Martin Diener
  • Sandra Bader

Detail Information

Publications56

  1. ncbi Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties
    Jérôme Leroy
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 25:6984-96. 2005
    ....
  2. ncbi Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit
    M Pragnell
    Howard Hughes Medical Institute, Department of Physiology, University of Iowa College of Medicine, Iowa City 52242
    Nature 368:67-70. 1994
    ..Conservation of the beta-subunit binding motif in these functionally distinct calcium channels suggests a critical role for the I-II cytoplasmic linker of the alpha 1-subunit in channel modulation by the beta-subunit...
  3. pmc Synaptic targeting of N-type calcium channels in hippocampal neurons
    Anton Maximov
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    J Neurosci 22:6939-52. 2002
    ..Our results provide a novel insight into the molecular mechanisms responsible for targeting of Ca2+ channels and other synaptic proteins in neurons...
  4. pmc Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation
    Meng Hua Zhou
    From the Department of Anesthesiology and Perioperative Medicine, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030
    J Biol Chem 290:30616-23. 2015
    ..S-Nitrosylation mediates the feedback regulation of N-type channels by NO...
  5. doi Distribution of voltage-dependent and intracellular Ca2+ channels in submucosal neurons from rat distal colon
    Matthias Rehn
    Institute for Veterinary Physiology and Biochemistry, Justus Liebig University, Giessen, Germany
    Cell Tissue Res 353:355-66. 2013
    ..Thus, rat submucosal neurons are equipped with various types of high-voltage activated Ca(v) channels and with IP3 receptors for intracellular Ca2+ signaling...
  6. doi Gβ₂ mimics activation kinetic slowing of CaV2.2 channels by noradrenaline in rat sympathetic neurons
    Juan M Hernández-Castellanos
    Department of Physiology, School of Medicine, Universidad Nacional Autonoma de Mexico UNAM, Apartado Postal 70250, C P 04510 México, D F, Mexico
    Biochem Biophys Res Commun 445:250-4. 2014
    ..These results advance our understanding on the mechanisms by which signals conveying from a variety of membrane receptors are able to display precise homeostatic responses. ..
  7. doi CaV2.2 channel cell surface expression is regulated by the light chain 1 (LC1) of the microtubule-associated protein B (MAP1B) via UBE2L3-mediated ubiquitination and degradation
    María A Gandini
    Department of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute, CINVESTAV IPN, Avenida IPN 2508, Colonia Zacatenco, Mexico DF, 07360, Mexico
    Pflugers Arch 466:2113-26. 2014
    ..Together these results revealed a novel functional coupling between LC1 and the N-type channels. ..
  8. ncbi Involvement of TRPM2 and L-type Ca²⁺ channels in Ca²⁺ entry and cell death induced by hydrogen peroxide in rat β-cell line RIN-5F
    Masakazu Ishii
    Department of Pharmacology, Toxicology and Therapeutics, Division of Physiology and Pathology, Showa University School of Pharmacy
    J Toxicol Sci 39:199-209. 2014
    ..Our results suggest that TRPM2 channels rather than L-type Ca²⁺ channels primarily contribute to H₂O₂-induced Ca²⁺ entry and cell death...
  9. pmc Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits
    John S Cassidy
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 111:8979-84. 2014
    ..2 and α2δ-1 is not disrupted by gabapentin. Altogether, these results demonstrate that CaV2.2 and α2δ-1 are intimately associated at the plasma membrane and allow us to infer a region of interaction. ..
  10. pmc The upregulation of α2δ-1 subunit modulates activity-dependent Ca2+ signals in sensory neurons
    Marianna D'Arco
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 35:5891-903. 2015
    ..2 channels. Thus, by controlling channel abundance at the plasma membrane, the α2δ-1 subunit has a major impact on the organization of depolarization-induced intracellular Ca(2+) signaling in dorsal root ganglion neurons. ..
  11. ncbi The R-Domain: Identification of an N-terminal Region of the α2δ-1 Subunit Which is Necessary and Sufficient for its Effects on Cav2.2 Calcium Currents
    Lele Song
    A 1022 Michael Smith Building, Manchester, M13 9PT U K
    Curr Mol Pharmacol 8:169-79. 2015
    ..We suggest, therefore, that Rd likely constitutes the major locus for physical interaction with the α1 subunit and may provide a target for novel Cav therapeutics...
  12. pmc Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons
    Eduardo Javier López Soto
    Laboratory of Electrophysiology and Laboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology IMBICE, B1904CMA La Plata, Buenos Aires, Argentina
    J Gen Physiol 146:205-19. 2015
    ....
  13. ncbi Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes
    R J Lewis
    Centre for Drug Design and Development 3D Centre, Institute for Molecular Bioscience, Department of Physiology and Pharmacology, CSIRO Tropical Agriculture, and Queensland Agricultural Biotechnology Centre QDPI, Australia
    J Biol Chem 275:35335-44. 2000
    ..1)H NMR studies reveal that CVID possesses a combination of unique structural features, including two hydrogen bonds that stabilize loop 2 and place loop 2 proximal to loop 4, creating a globular surface that is rigid and well defined...
  14. pmc Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating
    Francois Maingret
    Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille CRN2M, CNRS UMR 6231, Universite de la Mediterranee, Boulevard Pierre Dramard, 13916, Marseille Cedex 20, France
    Neuron 59:439-49. 2008
    ..Hence, neurotransmitter-initiated signaling cascades can dynamically regulate Ca2+ sensitivity of SK channels and directly influence somatic excitability...
  15. doi Role of spinal Cav2.2 and Cav2.1 ion channels in bladder nociception
    Xin Su
    Department of Urology, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    J Urol 179:2464-9. 2008
    ..To our knowledge this is the first study to evaluate the ability of various high voltage activated calcium channel blockers to inhibit the transmission of noxious stimuli from the bladder at the level of the spinal cord...
  16. pmc Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca²+ channel peptides
    Giovanna Bucci
    School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AJ, UK
    J Physiol 589:3085-101. 2011
    ..2 amino terminal and I-II loop contribute molecular determinants for Ca2+ channel function; the data favour a direct interaction of peptides with Ca2+ channels to inhibit synaptic transmission and attenuate G protein modulation...
  17. ncbi Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses
    Anita Scheuber
    Institut National de la Sante et de la Recherche Medicale, Equipe Mixte 224 Cortex et Epilepsie, Centre Hospitalier Universitaire Pitie Salpetriere, 75013 Paris, France
    J Neurosci 24:10402-9. 2004
    ..2 by G(o/i), thereby increasing the number of available channels...
  18. pmc Voltage-gated calcium channels
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    Cold Spring Harb Perspect Biol 3:a003947. 2011
    ..This article presents the molecular relationships and physiological functions of these Ca(2+) channel proteins and provides information on their molecular, genetic, physiological, and pharmacological properties...
  19. doi Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2
    Joel M Brittain
    Program in Medical Neuroscience, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    FEBS Lett 586:3813-8. 2012
    ..Cdk5-phosphorylated CRMP-2 had increased association with CaV2.2. These results identify an important role for Cdk5 in CRMP2-mediated CaV2.2 regulation...
  20. doi PIP₂ hydrolysis is responsible for voltage independent inhibition of CaV2.2 channels in sympathetic neurons
    Oscar Vivas
    Department of Physiology, School of Medicine, Universidad Nacional Autonoma de Mexico, Apartado Postal 70250, CP 04510 Mexico, DF, Mexico
    Biochem Biophys Res Commun 432:275-80. 2013
    ..These results support that the hydrolysis of PIP(2) is responsible for the voltage independent inhibition of Ca(V)2.2 channels...
  21. pmc Alternative splicing controls G protein-dependent inhibition of N-type calcium channels in nociceptors
    Jesica Raingo
    Department of Neuroscience, Brown University, Sidney E Frank Hall for Life Sciences, 185 Meeting Street, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:285-92. 2007
    ..Here we show that preferential inclusion in nociceptors of exon 37a in rat Cacna1b (encoding Ca(V)2.2) creates, de novo, a C-terminal module that mediates voltage-independent inhibition...
  22. ncbi The transmitter release-site CaV2.2 channel cluster is linked to an endocytosis coat protein complex
    Rajesh Khanna
    Genetics and Development Division, MP14 320, Toronto Western Research Institute, University Health Network, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Eur J Neurosci 26:560-74. 2007
    ..The most probable role of this subcomplex is to facilitate SV recovery after transmitter release...
  23. ncbi The presynaptic CaV2.2 channel-transmitter release site core complex
    Rajesh Khanna
    Genetics and Development Division, Toronto Western Research Institute, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8
    Eur J Neurosci 26:547-59. 2007
    ..2 in situ are also the most intimately attached. Our findings suggest that the CaV2.2 cluster is an integral element of a multimolecular vesicle-fusion module that forms the core of a multifunctional TRS...
  24. pmc The role of MAP1A light chain 2 in synaptic surface retention of Cav2.2 channels in hippocampal neurons
    A G Miriam Leenders
    Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3701, USA
    J Neurosci 28:11333-46. 2008
    ..2 to the actin cytoskeleton, thus contributing to presynaptic function...
  25. doi Alternative splicing in the synaptic protein interaction site of rat Ca(v)2.2 (alpha (1B)) calcium channels: changes induced by chronic inflammatory pain
    Sareh Asadi
    Neuroscience Research Center, Shahid Beheshti University M C, Tehran, Iran
    J Mol Neurosci 39:40-8. 2009
    ..Determining different Ca(v)2.2 splice variants in rat nervous system and the impact of inflammatory pain on the splicing pattern suggest a possible regulatory role for calcium channel alternative splicing...
  26. doi Gating charges per channel of Ca(V)2.2 channels are modified by G protein activation in rat sympathetic neurons
    Santiago Rebolledo-Antunez
    Departamento de Fisiologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico UNAM, Av Universidad 3000, Ciudad Universitaria, Delegacion Coyoacan, C P 04510, Apdo Postal 70250, Mexico, D F, Mexico
    Arch Biochem Biophys 486:51-7. 2009
    ..This paper shows for the first time a significant and reversible decrease in charge transfer of Ca(V)2.2 channels under G protein modulation, which might depend on the activated G protein inhibitory pathway...
  27. pmc An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels
    Joel M Brittain
    Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 284:31375-90. 2009
    ..Toxin block of Ca(2+) entry via CaV2.2 abolished this stimulated release. Thus, the CRMP-2-Ca(2+) channel interaction represents a novel mechanism for modulation of Ca(2+) influx into nerve terminals and, hence, of synaptic strength...
  28. pmc Scanning mutagenesis of the I-II loop of the Cav2.2 calcium channel identifies residues Arginine 376 and Valine 416 as molecular determinants of voltage dependent G protein inhibition
    Hugo W Tedford
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Canada
    Mol Brain 3:6. 2010
    ....
  29. doi G-proteins modulate invertebrate synaptic calcium channel (LCav2) differently from the classical voltage-dependent regulation of mammalian Cav2.1 and Cav2.2 channels
    Xuan Huang
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    J Exp Biol 213:2094-103. 2010
    ....
  30. pmc Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation
    Dominic Waithe
    Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St, London WC1E 6BT, United Kingdom
    J Biol Chem 286:9598-611. 2011
    ..In conclusion, there is a marked effect of β-subunits on Ca(V)2.2 expression, particularly in neurites, but our results point to protection from proteasomal degradation rather than masking of an ER retention signal...
  31. doi Bipartite syntaxin 1A interactions mediate CaV2.2 calcium channel regulation
    Jonathan N Davies
    Hotchkiss Brain Institute, Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Dr NW, Calgary AB, Canada T2N 4N1
    Biochem Biophys Res Commun 411:562-8. 2011
    ..Furthermore, we highlight the syntaxin 1A N-terminus as the minimal determinant for functional regulation of Ca(V)2.2 and Ca(V)2.3 channels...
  32. ncbi N-type Ca2+ channels as scaffold proteins in the assembly of signaling molecules for GABAB receptor effects
    Ryan W Richman
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 279:24649-58. 2004
    ..Our results suggest that the Ca(2+) channel alpha(1) subunit functions as a dynamic scaffold allowing assembly of intracellular signaling components that alter channel activity and route signals to the MAP kinase pathway...
  33. pmc Rat brain expresses a heterogeneous family of calcium channels
    T P Snutch
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Proc Natl Acad Sci U S A 87:3391-5. 1990
    ..The antisense oligonucleotide experiments specifically show that one or several of the Ca-channel classes are related to the Ca channels observed in rat brain mRNA injected oocytes...
  34. ncbi Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini
    J W Hell
    Department of Pharmacology, University of Washington, Seattle 98195
    J Biol Chem 269:7390-6. 1994
    ..Specific phosphorylation of the long form of the class B alpha 1 subunit by CaM kinase II may differentially regulate the function of N-type calcium channels containing different size forms of their alpha 1 subunits in vivo...
  35. ncbi Identification of functionally distinct isoforms of the N-type Ca2+ channel in rat sympathetic ganglia and brain
    Z Lin
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 18:153-66. 1997
    ....
  36. ncbi Delineation of the oligomerization, AP-2 binding, and synprint binding region of the C2B domain of synaptotagmin
    E R Chapman
    Department of Physiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 273:32966-72. 1998
    ..These studies provide the first structural information regarding C2B target protein recognition and provide the means to selectively disrupt synaptotagmin-effector interactions for functional studies...
  37. ncbi Alternative splicing of a short cassette exon in alpha1B generates functionally distinct N-type calcium channels in central and peripheral neurons
    Z Lin
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 19:5322-31. 1999
    ....
  38. ncbi Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: functional differences are beta subunit-specific
    J Q Pan
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    J Neurosci 20:4769-75. 2000
    ..The potential to mix and match multiple alpha(1B) splice variants and beta subunits probably represents a mechanism for controlling the plasticity of excitation-secretion coupling at different synapses...
  39. ncbi Mints as adaptors. Direct binding to neurexins and recruitment of munc18
    T Biederer
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:39803-6. 2000
    ..Our data support a model whereby one of the functions of Mints is to localize the vesicle fusion protein Munc18 to those sites at the plasma membrane that are defined by neurexins, presumably in the vicinity of points of exocytosis...
  40. ncbi Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis
    B Kornek
    Department of Neuroimmunology, Brain Research Institute, University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    Brain 124:1114-24. 2001
    ..Our data suggest that calcium influx through voltage-dependent calcium channels is one possible candidate mechanism for axonal degeneration in inflammatory demyelinating disorders...
  41. ncbi Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin
    T Coppola
    Institut de Biologie Cellulaire et de Morphologie, University of Lausanne, 1005 Lausanne, Switzerland
    J Biol Chem 276:32756-62. 2001
    ..We propose that the Rab3 effector RIM is a scaffold protein that participates through its multiple binding partners in the docking and fusion of secretory vesicles at the release sites...
  42. ncbi Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes
    Isabelle Latour
    Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada
    Glia 41:347-53. 2003
    ..Overall, our data indicate that astrocytes express multiple types of voltage-gated Ca(2+) channels, hinting at a complex regulation of Ca(2+) homeostasis in glial cells...
  43. ncbi Voltage-gated calcium channels in adult rat inferior colliculus neurons
    P N'GOUEMO
    Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007, USA
    Neuroscience 120:815-26. 2003
    ..We conclude that IC neurons express functionally all members of HVA Ca(2+) channels, but only a subset of these neurons appear to have developed functional LVA channels...
  44. ncbi Cell-specific alternative splicing increases calcium channel current density in the pain pathway
    Thomas J Bell
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 41:127-38. 2004
    ..8. Cell-specific inclusion of exon 37a correlates closely with significantly larger N-type currents in nociceptive neurons. This unique splice isoform of the N-type channel could represent a novel target for pain management...
  45. ncbi Differential role of N-type calcium channel splice isoforms in pain
    Christophe Altier
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Neurosci 27:6363-73. 2007
    ..In contrast, both N-type channel isoforms (e37a- and e37b-containing) contribute to tactile neuropathic allodynia. Hence, exon 37a acts as a molecular switch that tailors the channels toward specific roles in pain...
  46. ncbi A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C
    Dongjun Li
    Department of Physiology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Neurosci 25:1914-23. 2005
    ..Thus, the PP2calpha-Ca2+ channel complex is responsible for rapid dephosphorylation of Ca2+ channels and may contribute to regulation of synaptic transmission in neurons...
  47. ncbi A tctex1-Ca2+ channel complex for selective surface expression of Ca2+ channels in neurons
    Meizan Lai
    Department of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA
    Nat Neurosci 8:435-42. 2005
    ..These results underscore the importance of the specific tctex1-channel interaction in determining sorting and trafficking of neuronal Ca(2+) channels with different functionalities...
  48. ncbi Testosterone modulates Ca(v2.2) calcium channels' functional expression at rat levator ani neuromuscular junction
    S I Nudler
    Departamento de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    Neuroscience 134:817-26. 2005
    ..2) and transmitter release at the neuromuscular junctions of these sexually dimorphic motoneurons...
  49. ncbi Phoneutria nigriventer omega-Phonetoxin IIA: a new tool for anti-calcium channel autoantibody assays in Lambert-Eaton myasthenic syndrome
    Nicole Martin-Moutot
    INSERM U641, Marseille F 13916, France
    Neurobiol Dis 22:57-63. 2006
    ..1 and/or Cav2.2 antibodies detected using two different omega-conotoxins. Thus, the 125I-omegaPtxIIA assay detects a broader spectrum of autoantibody specificities than current omega-conotoxin-based assays...
  50. ncbi Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate
    Hongyu Fang
    Department of Anesthesiology, University of Virginia Health Sciences Systems, Charlottesville, Virginia 22908, USA
    J Biol Chem 281:20011-7. 2006
    ..The homologous sites in alpha(1) 2.2 and alpha(1) 2.3 subunits seem to be functionally different. The existence of an inhibitory phosphorylation site in the I-II linker seems to be unique to the alpha(1) 2.2 subunit...
  51. ncbi Differential distribution of voltage-gated calcium channels in dopaminergic neurons of the rat retina
    Paul Witkovsky
    Department of Ophthalmology, New York University School of Medicine, New York, New York 10016, USA
    J Comp Neurol 497:384-96. 2006
    ..Our findings are consistent with the available pharmacological data indicating that alpha1A and alpha1B calcium channels control the major fraction of dopamine release in the rat retina...
  52. ncbi Ca2+ enhances U-type inactivation of N-type (CaV2.2) calcium current in rat sympathetic neurons
    Yong Sook Goo
    Department of Physiology, Tulane University Medical School, New Orleans, Louisiana, USA
    J Neurophysiol 96:1075-83. 2006
    ..Taken together, the data support a role for extracellular divalent cations in modulating U-type inactivation. CDI appears to play a role in N-channel inactivation, but on a slower (sec) time scale...
  53. ncbi Ethanol withdrawal is accompanied by downregulation of calcium channel alpha 1B subunit in rat inferior colliculus neurons
    PROSPER N'GOUEMO
    Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20057, USA
    Brain Res 1108:216-20. 2006
    ..Thus, remodeling of N-type Ca(2+) channels may play an important role in neuronal hyperexcitability that leads to ethanol withdrawal seizures...
  54. ncbi BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling
    Henrike Berkefeld
    Institute of Physiology, University of Freiburg, Hermann Herder Strasse 7, 79104 Freiburg, Germany
    Science 314:615-20. 2006
    ..Complex formation with distinct Cav channels enables BKCa-mediated membrane hyperpolarization that controls neuronal firing pattern and release of hormones and transmitters in the central nervous system...
  55. pmc Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel
    S J Dubel
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada
    Proc Natl Acad Sci U S A 89:5058-62. 1992
    ..This brain Ca channel may mediate the omega-conotoxin-sensitive Ca influx required for neurotransmitter release at many synapses...
  56. ncbi A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners
    Rajesh Khanna
    Cellular and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    J Biochem Mol Biol 40:302-14. 2007
    ..Our results suggest that the channel is anchored to a cytoplasmic matrix related to the previously described particle web...

Research Grants1

  1. DOPAMINE AND RETINAL ADAPTATION
    Paul Witkovsky; Fiscal Year: 2001
    ....