C3

Summary

Gene Symbol: C3
Description: complement C3
Alias: complement C3, complement component 3
Species: rat

Top Publications

  1. pmc A role for immune complexes in enhanced respiratory syncytial virus disease
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 196:859-65. 2002
  2. ncbi Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma
    Koichi Hasegawa
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan
    Hum Genet 115:295-301. 2004
  3. ncbi Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families
    K C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Genes Immun 7:27-35. 2006
  4. ncbi Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population
    Xue Ting Pei
    The People Eye Center, Peking University People s Hospital, Beijing, China
    Curr Eye Res 34:615-22. 2009
  5. doi Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration
    Matt Rutar
    Research School of Biology, The Australian National University, Canberra, Australian Capital Territory, Australia
    Invest Ophthalmol Vis Sci 52:5347-58. 2011
  6. ncbi [Changes of the complement system in myelodysplastic syndromes]
    R Villaescusa Blanco
    Instituto de Hematologia e Inmunologia, Ciudad de La Habana, Cuba
    Sangre (Barc) 43:210-2. 1998
  7. ncbi Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury
    J E Jordan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 104:1413-8. 2001
  8. ncbi Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU)
    Purushottam Jha
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    J Immunol 176:7221-31. 2006
  9. pmc Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains
    Matthew C Pickering
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London W12 0NN, England, UK
    J Exp Med 204:1249-56. 2007
  10. pmc Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Immunol 179:2318-29. 2007

Scientific Experts

Detail Information

Publications99

  1. pmc A role for immune complexes in enhanced respiratory syncytial virus disease
    Fernando P Polack
    Department of Pediatrics, School of Medicine, Bloomberg School of Public Health at Johns Hopkins University, Baltimore, MD 21205, USA
    J Exp Med 196:859-65. 2002
    ..Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls...
  2. ncbi Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma
    Koichi Hasegawa
    Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Yokohama, Japan
    Hum Genet 115:295-301. 2004
    ..Recent studies have provided evidence that C3, C3a receptor, and C5 are linked to airway hyperresponsiveness...
  3. ncbi Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families
    K C Barnes
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Genes Immun 7:27-35. 2006
    Proinflammatory and immunoregulatory products from C3 play a major role in phagocytosis, respiratory burst, and airways inflammation...
  4. ncbi Association of c3 gene polymorphisms with neovascular age-related macular degeneration in a chinese population
    Xue Ting Pei
    The People Eye Center, Peking University People s Hospital, Beijing, China
    Curr Eye Res 34:615-22. 2009
    The purpose of this study was to determine whether the genetic polymorphisms of complement factor 3 (C3) are associated with neovascular age-related macular degeneration (AMD) in the Chinese population.
  5. doi Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration
    Matt Rutar
    Research School of Biology, The Australian National University, Canberra, Australian Capital Territory, Australia
    Invest Ophthalmol Vis Sci 52:5347-58. 2011
    ..To investigate the expression and localization of complement system mRNA and protein in a light-induced model of progressive retinal degeneration...
  6. ncbi [Changes of the complement system in myelodysplastic syndromes]
    R Villaescusa Blanco
    Instituto de Hematologia e Inmunologia, Ciudad de La Habana, Cuba
    Sangre (Barc) 43:210-2. 1998
    ..To search complement system activity and detection of circulating immune complexes in a group of patients with myelodysplastic syndromes (MDS) classified as with relatively favourable and unfavourable prognosis...
  7. ncbi Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury
    J E Jordan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 104:1413-8. 2001
    ..Although complement is widely accepted as participating in the pathophysiology of ischemia-reperfusion injury, the specific role of the lectin pathway has not been addressed...
  8. ncbi Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU)
    Purushottam Jha
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    J Immunol 176:7221-31. 2006
    ..Increased complement activation as determined by increased deposition of C3, C3 activation fragments, and membrane attack complex was observed in the eyes of Lewis rats when the function and/..
  9. pmc Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains
    Matthew C Pickering
    Molecular Genetics and Rheumatology Section, Faculty of Medicine, Imperial College, London W12 0NN, England, UK
    J Exp Med 204:1249-56. 2007
    ..an abundant serum glycoprotein that regulates the alternative pathway of complement-preventing uncontrolled plasma C3 activation and nonspecific damage to host tissues...
  10. pmc Development of Sjogren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3
    Cuong Q Nguyen
    Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
    J Immunol 179:2318-29. 2007
    ..In the present study, we examined the role of complement component-3 (C3) using a newly constructed C3-gene knockout mouse, C57BL/6.NOD-Aec1Aec2.C3(-/-)...
  11. pmc The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis
    Michael A Flierl
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 3:e2560. 2008
    ..Since blockade of both C5a receptors virtually abolished adrenomedullary apoptosis in vivo, C5aR and C5L2 become promising targets with implications on future complement-blocking strategies in the clinical setting of sepsis...
  12. doi Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist
    Robert J Collier
    Alcon Research, Ltd, Fort Worth, Texas 76134 2099, USA
    Invest Ophthalmol Vis Sci 52:8108-16. 2011
    ..This study evaluated retinal microglia, T-lymphocytes, and complement deposition in a light-induced retinopathy model. The effect of a serotonin (5-hydroxytryptamine, 5-HT(1A)) agonist on these processes was investigated...
  13. pmc Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice
    Qian Li
    Department of Otolaryngology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 79:2578-85. 2011
    ..Using mice deficient in complement C1qa, factor B, and factor B/C2, we found that complement C3 activation and opsonophagocytosis of S...
  14. doi Proteomic analysis of rat plasma following transient focal cerebral ischemia
    Ruoli Chen
    National Institute for Biological Standards and Control, Health Protection Agency, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, UK
    Biomark Med 5:837-46. 2011
    ..This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach...
  15. ncbi A murine model for the study of mycotic mastitis
    F A Guhad
    Department of Pathology and Infectious Diseases, Royal Veterinary College, University of London, UK
    J Comp Pathol 113:315-25. 1995
    ....
  16. ncbi Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus. The Shwartzman phenomenon revisited
    H M Belmont
    Department of Medicine, New York University Medical Center, New York
    Arthritis Rheum 37:376-83. 1994
    ..To test the hypothesis that during exacerbations of systemic lupus erythematosus (SLE), endothelial cells are activated to increase their expression of adhesion molecules...
  17. doi C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling
    Junxian Lim
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    FASEB J 27:822-31. 2013
    ....
  18. doi Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats
    Kazuya Ikeda
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Clin Exp Hypertens 36:58-63. 2014
    ..a synthetic phenotype and angiotensin II (Ang II) production associated with increased production of complement (C3). We hypothesized that C3 is involved in the growth of mesangial cells (MCs) from hypertensive rats...
  19. pmc CD36-mediated hematoma absorption following intracerebral hemorrhage: negative regulation by TLR4 signaling
    Huang Fang
    Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    J Immunol 192:5984-92. 2014
    ..TLR4 inhibition could promote hematoma absorption and significantly improve neurologic deficits following ICH. ..
  20. doi A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft
    Thusitha Gajanayake
    Department of Plastic, Reconstructive and Hand Surgery, Bern University Hospital, Inselspital, CH 3010 Bern, Switzerland Department of Clinical Research, University of Bern, CH 3010 Bern, Switzerland
    Sci Transl Med 6:249ra110. 2014
    ..Histopathological evaluation, including anti-graft antibodies and complement C3, revealed significantly reduced immune responses in the tacrolimus-hydrogel group compared with tacrolimus ..
  21. pmc Renal C3 complement component: feed forward to diabetic kidney disease
    Katherine J Kelly
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Ind, USA
    Am J Nephrol 41:48-56. 2015
    ..Diabetic nephropathy is the main cause of end-stage renal disease and has reached epidemic proportions...
  22. pmc Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice
    Yijie Zhang
    Department of Cardiology, Wuhan University, Renmin Hospital, 238 Jiefang Road, Wuhan, 430060, Peoples Republic of China
    Cardiovasc Diabetol 14:69. 2015
    ..We hypothesized that cardiospecific suppression of CD36, the predominant membrane FA transporter, would protect against obesity-related cardiomyopathy...
  23. ncbi Activation of complement C3, C5, and C9 genes in tumors treated by photodynamic therapy
    Brandon Stott
    British Columbia Cancer Agency, Vancouver, BC, Canada
    Cancer Immunol Immunother 56:649-58. 2007
    ..The expression of genes encoding complement proteins C3, C5, and C9 was studied following tumor PDT mediated by photosensitizer Photofrin using mouse Lewis lung carcinoma (..
  24. pmc A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population
    Suiho Yanagisawa
    Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    PLoS ONE 6:e28847. 2011
    Genetic variants in the complement component 3 gene (C3) have been shown to be associated with age-related macular degeneration (AMD) in Caucasian populations of European descent...
  25. ncbi CD36 deficiency rescues lipotoxic cardiomyopathy
    John Yang
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 100:1208-17. 2007
    ....
  26. pmc Intravenous immunoglobulin (IVIG) attenuates antibody binding in acute haemorrhagic immunopneumonitis in a rat model of complement-dependent lung injury
    M Dantas
    Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Clin Exp Immunol 121:139-45. 2000
    ..Pulmonary damage was evaluated by light microscopy; C3 deposits and the binding of immunoglobulins to the alveolar septa were assayed by immunofluorescence...
  27. ncbi Structure at 1.44 A resolution of an N-terminally truncated form of the rat serum complement C3d fragment
    G Zanotti
    Department of Organic Chemistry and Biopolymer Research Center, University of Padova, Italy
    Biochim Biophys Acta 1478:232-8. 2000
    Complement component C3 plays a key role in the complement-mediated immune defence, and occupies a central position within the complement cascade system...
  28. ncbi Phosphorylation of ATPase subunits of the 26S proteasome
    G G Mason
    Department of Biochemistry, School of Medical Sciences, University of Bristol, UK
    FEBS Lett 430:269-74. 1998
    ..Some differences were observed in the 2D-PAGE pattern of proteasomes immunoprecipitated from cultured cells compared to purified rat liver 26S proteasomes suggesting possible differences in subunit compositions of 26S proteasomes...
  29. ncbi C-reactive protein and complement components but not other acute-phase reactants discriminate between clinical subsets and organ damage in systemic lupus erythematosus
    Luis M Amezcua-Guerra
    Department of Immunology and Microbiology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico
    Clin Lab 57:607-13. 2011
    ..Nonetheless, several acute-phase proteins may remain normal or are decreased. We explore the association of diverse biomarkers with selected clinical features, disease activity, and organ damage in SLE...
  30. ncbi Overexpression of innate immune response genes in a model of recessive polycystic kidney disease
    M Mrug
    Division of Genetic and Translational Medicine, Department of Medicine, The University of Alabama at Birmingham, 720 20th Street South, Birmingham, AL 35294, USA
    Kidney Int 73:63-76. 2008
    ..expression of macrophage activators was dominated by the complement system factors including the central complement component 3. Additional studies confirmed increased complement component 3 protein levels in both cystic and non-..
  31. ncbi Vascular C3 deposits on renal biopsy in pediatric patients with hematuria
    R D Sheth
    Department of Pediatrics, Texas Children s Hospital and Baylor College of Medicine, Houston 77030 2399, USA
    Pediatr Nephrol 14:797-801. 2000
    Isolated deposition of the third component of complement (C3) in the renal arterioles has been noted on biopsy specimens in patients with hematuria...
  32. doi Minocycline effects on the cerebrospinal fluid proteome of experimental autoimmune encephalomyelitis rats
    Marcel P Stoop
    Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Proteome Res 11:4315-25. 2012
    ..Two of these proteins, complement C3 and carboxypeptidase B2, were validated by quantitative LC-MS/MS in the SRM mode...
  33. pmc 670-nm light treatment reduces complement propagation following retinal degeneration
    Matt Rutar
    The John Curtin School of Medical Research, College of Medicine, Biology and Environment, The Australian National University, Building 131, Garran Rd, Canberra ACT 2601, Australia
    J Neuroinflammation 9:257. 2012
    ..Complement activation is associated with the pathogenesis of age-related macular degeneration (AMD). We aimed to investigate whether 670-nm light treatment reduces the propagation of complement in a light-induced model of atrophic AMD...
  34. ncbi Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1/IRF-1 pathway during tolerance induction
    Shaun P Cordoba
    AW Morrow Liver Immunobiology Laboratory, Centenary Institute, UNSW Sydney, Australia
    Liver Transpl 12:636-43. 2006
    ..More immune genes were increased in TOL vs. REJ on day 1, including STAT-1, IRF-1 and complement C3. Differential expression of selected genes was confirmed by quantitative RT-PCR...
  35. ncbi Serum complement C3 predicts renal arteriolosclerosis in non-diabetic chronic kidney disease
    Chiari Kojima
    Department of Internal Medicine IV, Tokyo Women s Medical University, Tokyo, Japan
    J Atheroscler Thromb 19:854-61. 2012
    b>Complement C3 (C3) is one of the major mediators of inflammation. Serum C3 has been shown to be correlated with the presence of atherosclerosis...
  36. ncbi Intraglomerular synthesis of complement C3 and its activation products in IgA nephropathy
    K Abe
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1, Sakamoto, Nagasaki 852 5201, Japan
    Nephron 87:231-9. 2001
    Complement activation is thought to be pathologically important in IgA nephropathy (IgAN). Although C3 deposition in the mesangium is found in IgAN, the origin of C3 is not clear...
  37. doi Blast-induced moderate neurotrauma (BINT) elicits early complement activation and tumor necrosis factor α (TNFα) release in a rat brain
    Jurandir J Dalle Lucca
    Immunomodulation of Trauma Program, US Army Institute of Surgical Research, 3650 Chambers Pass, BHT2 Building 3610, Fort Sam Houston, TX 78234, USA
    J Neurol Sci 318:146-54. 2012
    ..Moderate blast triggers moderate brain injuries, elevated levels of local brain C3/C5b-9 and systemic C5b-9, increased leukocyte infiltration, unregulated tumor necrosis factor alpha (TNFα), and ..
  38. doi Profiling and identification of cerebrospinal fluid proteins in a rat EAE model of multiple sclerosis
    Therese Rosenling
    Department of Analytical Biochemistry, Centre for Pharmacy, University of Groningen, Groningen, The Netherlands
    J Proteome Res 11:2048-60. 2012
    ..Lysozyme C1, fetuin B, T-kininogen, serum paraoxonase/arylesterase 1, glutathione peroxidase 3, complement C3, and afamin are among the proteins significantly elevated in this rat EAE model...
  39. doi Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice
    Xiaoyan Xiao
    Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    J Autoimmun 32:85-93. 2009
    ..We also found that IgG deposits in the glomeruli of diabetic NOD mice were accompanied by the presence of complement C3. Moreover, the serum from diabetic mice contained autoantibodies directed towards components of the glomeruli ..
  40. pmc A complex role for complement in allergic asthma
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, OH 45229, USA
    Expert Rev Clin Immunol 6:269-77. 2010
    ..Different models of experimental allergic asthma suggest that the small complement fragments of C3 and C5, the anaphylatoxins C3a and C5a, not only promote proallergic effector functions during the allergic effector ..
  41. doi Alterations in gene expression of complement components in chronic rhinosinusitis
    Rodney J Schlosser
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
    Am J Rhinol Allergy 24:21-5. 2010
    ..rhinosinusitis (AFRS), CRS without NPs (CRS-NPs), and controls were harvested and gene and protein expression of C3, factor B (fB), C5, and C7 complement proteins were analyzed using quantitative polymerase chain reaction and ..
  42. pmc A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection
    Kevin B O'Brien
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS ONE 6:e17377. 2011
    ..b>C3, a member of the complement system of serum proteins, is a major component of the innate immune and inflammatory ..
  43. doi Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer
    Xu Wei Cai
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48108, USA
    Int J Radiat Oncol Biol Phys 77:867-76. 2010
    ..To study whether radiation induces differential changes in plasma proteomics in patients with and without radiation-induced lung toxicity (RILT) of Grade >/=2 (RILT2)...
  44. ncbi Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
    M M Griffiths
    Department of Veterans Affairs Medical Center, and University of Utah, Salt Lake City, USA
    Arthritis Rheum 43:1278-89. 2000
    ..Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats...
  45. doi Regulation of murine splenic B cell CR3 expression by complement component 3
    Amanda C Jacobson
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Immunol 183:3963-70. 2009
    Complement component C3 has established roles in both innate and adaptive immune responses. C3 cleavage products function in B cell activation through the complement receptors CD21/35...
  46. doi Defective solubilization of immune complexes and activation of the complement system in patients with pulmonary tuberculosis
    P Senbagavalli
    Department of Clinical Pathology, Tuberculosis Research Centre, Chetput, Chennai 600031, India
    J Clin Immunol 29:674-80. 2009
    ....
  47. doi Complement factors C3a and C5a have distinct hemodynamic effects in the rat
    Lavinia M Proctor
    School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
    Int Immunopharmacol 9:800-6. 2009
    ..In contrast to C3a, C5a infusion resulted in hypotension, and rapid and transient neutropenia. These results demonstrate that C3a and C5a mediate distinct effects on blood pressure and circulating polymorphonuclear leukocytes in the rat...
  48. ncbi The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis
    Trent M Woodruff
    School of Biomedical Sciences, University of Queensland, Brisbane, Australia
    J Immunol 181:8727-34. 2008
    ..With end-stage disease, SOD1(G93A) rats displayed marked deposition of C3/C3b, and a significant up-regulation of the C5aR in the lumbar spinal cord...
  49. doi Complement components (C3, C4) as inflammatory markers in asthma
    Mohammed Abdel Fattah
    Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt
    Indian J Pediatr 77:771-3. 2010
    To assess the serum levels of complement factors C3 and C4 in Egyptian asthmatic children.
  50. doi Complement component C3 functions as an embryotrophic factor in early postimplantation rat embryos
    Makoto Usami
    Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Int J Dev Biol 54:1277-85. 2010
    ..for early postimplantation rat embryos, partially purified from rat serum, was identified as complement component C3 (C3), the central component of the complement system, by sequence analysis of its N-terminal...
  51. pmc Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    Stephane Lajoie
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Immunol 11:928-35. 2010
    ..The opposing effects of C3a and C5a were mediated through their reciprocal regulation of IL-23 production. These data demonstrate a critical role for complement-mediated regulation of the IL-23-T(H)17 axis in severe asthma...
  52. doi Perivascular adipose tissue-derived complement 3 is required for adventitial fibroblast functions and adventitial remodeling in deoxycorticosterone acetate-salt hypertensive rats
    Cheng Chao Ruan
    Laboratory of Vascular Biology and Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Arterioscler Thromb Vasc Biol 30:2568-74. 2010
    ..To examine the role of perivascular adipose tissue (PVAT)-derived factors in the regulation of adventitial fibroblast (AF) function in vitro and in vivo...
  53. doi Complement 3 activates the KLF5 gene in rat vascular smooth muscle cells
    En Hui Yao
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Ooyaguchi kami 30 1, Itabashi ku, Tokyo 173 8610, Japan
    Biochem Biophys Res Commun 367:468-73. 2008
    ..smooth muscle cells (VSMCs) change to the synthetic phenotype and show increased expression of complement 3 (C3) and that C3 plays a role in the change to the synthetic phenotype...
  54. doi Complement inhibition alleviates paraquat-induced acute lung injury
    Shihui Sun
    State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
    Am J Respir Cell Mol Biol 45:834-42. 2011
    ..Within 24 hours of PQ-induced ALI, there was significantly increased expression of the complement proteins, C1q and C3, in the lung. Expression of the anaphylatoxin receptors, C3aR and C5aR, was also increased...
  55. ncbi Treatment with mycophenolate mofetil attenuates the development of Heymann nephritis
    M E Luca
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Nephrol 8:77-83. 2000
    ..Glomerular complement component C3, however, was significantly lower in the mycophenolate mofetil treated rats...
  56. ncbi Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation
    Y Fukuoka
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    Biochem Biophys Res Commun 242:663-8. 1998
    ..These results suggest that expression of C3aR and C5aR is independently regulated in rat cells and tissues...
  57. ncbi Complement component 3 (C 3) and diabetes mellitus
    S Krantz
    Institute of Biochemistry, Ernst Moritz Arndt University Greifswald, GDR
    Exp Clin Endocrinol 92:287-96. 1988
    Complement factor 3 (C3) phenotype and allele frequencies were defined in 312 patients with Type 1 diabetes (IDDM), 256 patients with Type 2 diabetes mellitus (NIDDM), 114 apparently healthy first-degree relatives of Type 1 diabetics, in ..
  58. ncbi Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin
    W Kellermann
    Institut für Anaesthesiologie, Universitat Munchen
    Klin Wochenschr 67:190-5. 1989
    ..The relation between PLA and neopterin shown in the study is consistent with the possibility of macrophages being a source of the plasma PLA, as reported in experimental studies...
  59. pmc Nucleotide and deduced amino acid sequence of rat complement C3
    Y Misumi
    Department of Biochemistry, Fukuoka University School of Medicine, Japan
    Nucleic Acids Res 18:2178. 1990
  60. pmc Molecular basis of hereditary C3 deficiency
    M Botto
    Department of Medicine, Royal Postgraduate Medical School, London, United Kingdom
    J Clin Invest 86:1158-63. 1990
    Hereditary deficiency of complement component C3 in a 10-yr-old boy was studied. C3 could not be detected by RIA of serum from the patient...
  61. ncbi Purification, characterization, and amino acid sequence of rat anaphylatoxin (C3a)
    J W Jacobs
    Biochemistry 17:5031-8. 1978
    ..Antisera raised to the purified rat peptide do not cross-react immunologically by Ouchterlony analysis with either human or porcine C3a...
  62. ncbi Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats
    Rita M Cowell
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 23:9459-68. 2003
    ..With immunofluorescence assays and confocal microscopy, both C3 and C9 were localized to injured neurons 16 and 24 hr post-HI...
  63. ncbi Complement components (C3, C4) in childhood asthma
    F I E Najam
    Department of Laboratory Medicine, Faculty of Medicine, Al Arab Medical University, Benghazi, Libya
    Indian J Pediatr 72:745-9. 2005
    To assess the involvement of complements (C3, C4) in the pathophysiology of bronchial asthma.
  64. pmc Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration
    Itzhak Ben-David
    Department of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Respir Cell Mol Biol 33:476-82. 2005
    ..When parallel experiments were performed in complement C3-deficient mice, no suppression of the second inoculum was noted, suggesting that early upregulation of ..
  65. pmc Innate immune defense against pneumococcal pneumonia requires pulmonary complement component C3
    Alison R Kerr
    Division of Infection and Immunity, IBLS, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Infect Immun 73:4245-52. 2005
    ..By intranasally infecting transgenic mice unable to express complement C3, we investigated the role of complement in pulmonary defenses against S. pneumoniae...
  66. ncbi Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor
    Fabio Fischetti
    Department of Physiology and Pathology, University of Trieste, Trieste, Italy
    Blood 106:2340-6. 2005
    ..Anti-beta2-glycoprotein I-depleted aPL IgG failed to induce PLAs and TOs. C3 and C9 colocalized with aPL IgG on the mesenteric vessels...
  67. ncbi Regulation of complement C3 expression by the bile acid receptor FXR
    Jiali Li
    Department of Biology, X Ceptor Therapeutics Inc, San Diego, California 92121, USA
    J Biol Chem 280:7427-34. 2005
    ..The analysis of the human complement C3 gene reveals the presence of functional FXR response elements in the proximal promoter of C3...
  68. ncbi Rat uterine complement C3 expression as a model for progesterone receptor modulators: characterization of the new progestin trimegestone
    S G Lundeen
    Endocrinology Division, Women s Health Research Institute, Wyeth Ayerst Research, 145 King of Prussia Road, Radnor, PA 19087 USA
    J Steroid Biochem Mol Biol 78:137-43. 2001
    ..Here we report the development and characterization of the rat uterine complement component C3 mRNA as a molecular target for the evaluation of the antiestrogenic activity of progestins in the uterus...
  69. ncbi Rat membrane cofactor protein (MCP; CD46) is expressed only in the acrosome of developing and mature spermatozoa and mediates binding to immobilized activated C3
    Masashi Mizuno
    Complement Biology Group, Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Cardiff CF14 4XN, United Kingdom
    Biol Reprod 71:1374-83. 2004
    ..Acrosome-reacted but not unreacted spermatozoa bound methylamine-activated C3 immobilized on plastic...
  70. ncbi Complement activation following optic nerve crush in the adult rat
    Marcus Ohlsson
    Department of Clinical Neuroscience, Section of Neurosurgery, Karolinska Institutet and Hospital, 171 76 Stockholm, Sweden
    J Neurotrauma 20:895-904. 2003
    ..b>Complement C3-mRNA was upregulated 2-28 days post lesion, indicating local synthesis of complement in the optic nerve...
  71. ncbi Intravenous immunoglobulin protects against experimental thrombotic microangiopathy
    J A Jefferson
    Division of Nephrology, University of Washington, Seattle, Washington, USA
    Kidney Int 60:1018-25. 2001
    ..utilized in several forms of vasculitis and has many potential mechanisms of action, including the inhibition of C3 activation...
  72. ncbi Increase in complement component C3 is an early response to experimental magnesium deficiency in rats
    F I Bussière
    Centre de Recherches en Nutrition Humaine d Auvergne, Unite Maladies Metaboliques et Micronutriments, INRA, Theix, 63122 St Genes Champanelle, France
    Life Sci 73:499-507. 2003
    ..of Mg-deficiency on complement system by measuring total C3 concentration, mRNA abundance for rat pre-pro complement C3 in liver by RT-PCR, complement haemolytic activity and C3 activation by Western Blot was studied...
  73. ncbi Responsiveness of endometrial genes Connexin26, Connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens
    S Heikaus
    Institute of Anatomy, University Hospital Essen, D 45122 Essen, Germany
    J Mol Endocrinol 29:239-49. 2002
    ..The gap junction connexin (Cx) genes Cx26 and Cx43, the plasma glycoprotein clusterin gene and the complement C3 gene are highly regulated by estrogen in rat endometrium...
  74. ncbi Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy
    S M Drouin
    Institute of Molecular Medicine for the Prevention of Human Diseases, Department of Biochemistry and Molecular Biology, University of Texas, Houston, TX 77030, USA
    J Immunol 167:4141-5. 2001
    ..Historically, complement was not thought to contribute to the pathogenesis of asthma. However, using C3-deficient mice in an allergen-induced model of pulmonary allergy, we demonstrate that complement may impact key ..
  75. ncbi Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection
    Sharookh B Kapadia
    Department of Immunology and Pathology, Department of Molecular Microbiology, Washington University School of Medicine, Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Immunity 17:143-55. 2002
    ..We evaluated the role of complement factor C3 (C3) and the murine gamma-herpesvirus 68 (gammaHV68) RCA protein in viral pathogenesis...
  76. ncbi Down-regulation of complement receptor 3 and major histocompatibility complex I and II antigen-like immunoreactivity accompanies ramification in isolated rat microglia
    Kayvon Salimi
    Laboratory of Psychiatry, Clinic of Psychiatry, University Hospital Innsbruck, Anichstr 35, Austria
    Brain Res 946:283-9. 2002
    ..The results attest to the special efficacy of this culture method for the investigation of the early microglial reaction by use of highly sensitive immunophenotypic criteria...
  77. ncbi Genetic-biochemical criteria for individual sensitivity in development of occupational bronchopulmonary diseases
    N F Izmerov
    Institute of Occupational Health, Russian Academy of Medical Sciences, Moscow, Russia
    Cent Eur J Public Health 10:35-41. 2002
    ..pathology (BPP) and the immune status of the body: proteinase inhibitor (Pi), third component of the complement (C3), transferrin (Tf), group-specific component of blood serum (Gc), haptoglobin (Hp), erythrocytic glyoxalase (Glo) ..
  78. ncbi Involvement of dipeptidyl peptidase IV in immune complex-mediated glomerulonephritis
    Toshihiro Shinosaki
    Shionogi Discovery Research Laboratories, Shionogi and Company, Ltd, Toyonaka City, Osaka, Japan
    Lab Invest 82:505-13. 2002
    ..Treatment with F16 inhibited glomerular deposition of complement C3 and complement C4 after the binding of E30 to the mesangial cell surface...
  79. ncbi Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci
    T Furuya
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 1820, USA
    Hum Mol Genet 9:2241-50. 2000
    ..Our data support the view that multiple autoimmune diseases may share genetic risk factors, and suggest that many of these loci are gender influenced...
  80. doi Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy
    Koh Ichi Yuhki
    Department of Pharmacology, Asahikawa Medical College, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    J Pharmacol Exp Ther 325:601-9. 2008
    ..cavity after zymosan injection was confirmed, and preinjection of cobra venom factor (CVF), to deplete blood complement C3, was significantly suppressed after zymosan-induced exudate formation in WT mice...
  81. ncbi Cathepsin B and complement C3 are major comigrants in the estrogen-induced peroxidase fraction of rat uterine fluid
    K V Balan
    Department of Biology, Howard University, Washington, DC, USA
    J Submicrosc Cytol Pathol 33:221-30. 2001
    ..bands isolated from SDS-PAGE gels from the size-exclusion purified peroxidase fraction showed the presence of complement C3 along with novel previously uncharacterized proteins...
  82. ncbi A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease
    Ernesto Silva
    Department of Medicine, Division of Respiratory Medicine, Karolinska University Hospital, Stockholm, Sweden
    Sarcoidosis Vasc Diffuse Lung Dis 24:24-32. 2007
    ..These diseases have several similarities from their clinical aspects. The aim of this study was to compare the protein profile at the site of active inflammation i.e. the lungs of patients with sarcoidosis and CBD...
  83. ncbi Complement activation contributes to leukocyte recruitment and neuropathic pain following peripheral nerve injury in rats
    Man Li
    School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Eur J Neurosci 26:3486-500. 2007
    ..We found that C3 deposition significantly increased from 6 h to 7 days in the injured nerve and was associated with the extent of ..
  84. ncbi C-reactive protein and natural IgM antibodies are activators of complement in a rat model of intestinal ischemia and reperfusion
    Niubel Diaz Padilla
    Department of Immunopathology, Sanquin Research, Plesmalaan 125, Amsterdam, The Netherlands
    Surgery 142:722-33. 2007
    ..The effect of C1-esterase inhibitor (C1-Inh) on this complement activation along with other inflammatory mediators was also studied...
  85. pmc Autoantibodies in patients with chronic obstructive pulmonary disease
    Carol A Feghali-Bostwick
    Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 177:156-63. 2008
    ..Adaptive immune responses are present in patients with chronic obstructive pulmonary disease (COPD), and it has been postulated that these processes could be autoreactive...
  86. pmc Cirrhosis-induced defects in innate pulmonary defenses against Streptococcus pneumoniae
    Katie L Propst-Graham
    Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
    BMC Microbiol 7:94. 2007
    ....
  87. doi Association study of the C3 gene with adult and childhood asthma
    Hiroki Inoue
    Department of Public Health, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, 260 8670, Japan
    J Hum Genet 53:728-38. 2008
    ..It has been shown that complement-C3-deficient mice have reduced inflammation of asthmatic airways...
  88. ncbi [MRNA expression of complement C3 and C4 in rat nasal mucosa with allergic rhinitis]
    Jun tian Lang
    Department of Otorhinolaryngology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 41:928-31. 2006
    To investigate the level of mRNA expression of complement C3 and C4 in rat nasal mucosa and to reveal the relationship with the pathogenesis of allergic rhinitis (AR) .
  89. ncbi Expression and activation of complement protein and alveolar damage during Pneumocystis pneumonia
    Mark E Lasbury
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 1120 South Drive, Fesler Hall Rm 406, Indianapolis, Indiana 46202, USA
    J Eukaryot Microbiol 53:S136-7. 2006
  90. ncbi Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity
    Jinrong Fu
    Department of Cardiology, Renmin Hospital, Wuhan University School of Medicine, Wuhan, Hubei, PR China
    Biochem Biophys Res Commun 350:162-8. 2006
    b>C3 is common to all pathways of complement activation augmenting ischemia/reperfusion (I/R)-induced myocardial injury and cardiac dysfunction...
  91. ncbi Species difference in correlation between in vivo/in vitro liposome-complement interactions
    T M Huong
    Department of Pharmacokinetics and Pharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Japan
    Biol Pharm Bull 24:439-41. 2001
    ..Third component of the complement (C3) fragments associated with hydrogenated egg phosphatidylcholine (HEPC)-based liposomes in vivo and complement-..
  92. ncbi Retinal synthesis and deposition of complement components induced by ocular hypertension
    Markus H Kuehn
    Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Exp Eye Res 83:620-8. 2006
    ..Toward this goal the gene expression levels of complement components 1qb (C1qb) and 3 (C3) were determined in the retina by quantitative polymerase chain reaction in human eyes with elevated intraocular ..
  93. ncbi The metabolic syndrome in relation to complement component 3 and postprandial lipemia in patients from an outpatient lipid clinic and healthy volunteers
    Antonie J H H M van Oostrom
    Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands
    Atherosclerosis 190:167-73. 2007
    We investigated the relationship between complement component 3 (C3), fasting and postprandial lipemia and the metabolic syndrome (MetabS)...
  94. pmc Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model
    B H M Heijnen
    Department of Surgery, Surgical Laboratory, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Exp Immunol 143:15-23. 2006
    ..Immunohistochemical assessment indicated that activated C3, the membrane attack complex C5b9 and C-reactive protein (CRP) colocalized in hepatocytes within midzonal areas, ..
  95. ncbi Estrogen regulation of tissue-specific expression of complement C3
    S A Sundstrom
    Department of Obstetrics and Gynecology, University of Pennsylvania, School of Medicine, Philadelphia 19104
    J Biol Chem 264:16941-7. 1989
    ..This LE-1 cDNA was sequenced and shown to be homologous to complement component C3. The sequence was approximately 81 and 90% homologous to human and mouse C3, respectively...

Research Grants4

  1. Complement inhibition in experimental autoimmune uveitis
    RUSSELL READ; Fiscal Year: 2006
    ..abstract_text> ..
  2. Genetic Studies of Immune Responsiveness to Cockroach
    Kathleen Barnes; Fiscal Year: 2007
    ..We will also examine the interactive effect of current cockroach allergen exposure and susceptibility loci associated with asthma severity. ..
  3. AIRWAY DISEASE AND COCKROACH EXPOSURE IN PUBLIC HOUSING
    Kathleen Barnes; Fiscal Year: 2008
    ..We hope that with the data to be generated, we will positively impact the health of urban US populations who are disproportionally suffering from asthma morbidity and mortality. ..
  4. Genome-Wide Association Studies of Asthma in Populations of African Descent
    Kathleen Barnes; Fiscal Year: 2008
    ..Findings from this study will provide a better understanding of the complex pathways related to risk of asthma and associated phenotypes. [unreadable] [unreadable] [unreadable]..