brevican

Summary

Gene Symbol: brevican
Description: brevican
Alias: ALPBRE, BEHAB, brevican core protein, brain-enriched hyaluronan-binding protein, brevican (brain specific proteoglycan in the aggrecan family)
Species: rat

Top Publications

  1. pmc Brevican knockdown reduces late-stage glioma tumor aggressiveness
    Chrissa A Dwyer
    SUNY Upstate Medical University, Syracuse, NY, USA
    J Neurooncol 120:63-72. 2014
  2. ncbi cDNA cloning and the identification of an aggrecanase-like cleavage site in rat brevican
    H Yamada
    Cancer Research Center, La Jolla Cancer Research Foundation, CA 92037, USA
    Biochem Biophys Res Commun 216:957-63. 1995
  3. pmc BEHAB, a new member of the proteoglycan tandem repeat family of hyaluronan-binding proteins that is restricted to the brain
    D M Jaworski
    Yale University School of Medicine, Section of Neurobiology, New Haven, Connecticut 06510
    J Cell Biol 125:495-509. 1994
  4. ncbi Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms
    C I Seidenbecher
    Federal Institute for Neurobiology, Magdeburg, Germany
    J Biol Chem 270:27206-12. 1995
  5. pmc The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety
    A Aspberg
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 94:10116-21. 1997
  6. ncbi Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats
    W Yuan
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa 33612 4799, USA
    Neuroscience 114:1091-101. 2002
  7. ncbi Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue
    Xiufeng Tang
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 71:427-44. 2003
  8. ncbi A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma
    Mariano S Viapiano
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:33239-47. 2003
  9. ncbi The effect of hypoxic-ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2
    James Aya-ay
    Shriners Hospital for Children, University of South Florida, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa, FL 33612 4799, USA
    Exp Neurol 193:149-62. 2005
  10. ncbi Altered production and proteolytic processing of brevican by transforming growth factor beta in cultured astrocytes
    Michelle G Hamel
    University of South Florida College of Medicine, Department of Pharmacology and Therapeutics, Tampa, Florida, USA
    J Neurochem 93:1533-41. 2005

Detail Information

Publications12

  1. pmc Brevican knockdown reduces late-stage glioma tumor aggressiveness
    Chrissa A Dwyer
    SUNY Upstate Medical University, Syracuse, NY, USA
    J Neurooncol 120:63-72. 2014
    ..Brain Enriched Hyaluronan Binding (BEHAB)/brevican (B/b), is a CNS-specific ECM constituent and is upregulated in the glioma TME...
  2. ncbi cDNA cloning and the identification of an aggrecanase-like cleavage site in rat brevican
    H Yamada
    Cancer Research Center, La Jolla Cancer Research Foundation, CA 92037, USA
    Biochem Biophys Res Commun 216:957-63. 1995
    ..In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a 145-kDa full-length form and an 80-kDa C-terminal fragment...
  3. pmc BEHAB, a new member of the proteoglycan tandem repeat family of hyaluronan-binding proteins that is restricted to the brain
    D M Jaworski
    Yale University School of Medicine, Section of Neurobiology, New Haven, Connecticut 06510
    J Cell Biol 125:495-509. 1994
    ..We propose the name BEHAB, Brain Enriched HyAluronan Binding protein, for this gene...
  4. ncbi Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms
    C I Seidenbecher
    Federal Institute for Neurobiology, Magdeburg, Germany
    J Biol Chem 270:27206-12. 1995
    ..6 kilobases (kb). The 3.6-kb transcript encodes a polypeptide that exhibits 82% sequence identity with bovine brevican and is thought to be the rat ortholog of brevican...
  5. pmc The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety
    A Aspberg
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 94:10116-21. 1997
    The lecticans are a family of chondroitin sulfate proteoglycans including aggrecan, versican, neurocan, and brevican. The C-terminal globular domains of lecticans are structurally related to selectins, consisting of a C-type lectin domain ..
  6. ncbi Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats
    W Yuan
    Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa 33612 4799, USA
    Neuroscience 114:1091-101. 2002
    ..with thrombospondin motifs)-mediated cleavage of the aggregating chondroitin sulfate proteoglycan, brevican, have been identified, but not localized in the CNS...
  7. ncbi Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue
    Xiufeng Tang
    Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 71:427-44. 2003
    ..neurocan, NG2, and 250/200 kD tenascin-C were reached at 8 days, with maximum levels of phosphacan and 140/80 kD brevican attained later, at 1 month post injury...
  8. ncbi A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma
    Mariano S Viapiano
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:33239-47. 2003
    BEHAB (brain-enriched hyaluronan-binding protein)/brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult rat brain...
  9. ncbi The effect of hypoxic-ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2
    James Aya-ay
    Shriners Hospital for Children, University of South Florida, MDC Box 9, 12901 Bruce B Downs Boulevard, Tampa, FL 33612 4799, USA
    Exp Neurol 193:149-62. 2005
    ..b>Brevican is an aggregating chondroitin sulfate proteoglycan (CSPG) secreted by OLs and their progenitors prior to and ..
  10. ncbi Altered production and proteolytic processing of brevican by transforming growth factor beta in cultured astrocytes
    Michelle G Hamel
    University of South Florida College of Medicine, Department of Pharmacology and Therapeutics, Tampa, Florida, USA
    J Neurochem 93:1533-41. 2005
    b>Brevican, a proteoglycan of the lectican family, inhibits neurite outgrowth and may also stabilize synapses. Little is known about its expression or function in vitro...
  11. ncbi Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures
    Nora John
    Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany
    Mol Cell Neurosci 31:774-84. 2006
    ..b>Brevican, a chondroitin sulfate proteoglycan, is an integral component of PNN...
  12. ncbi Versican and brevican are expressed with distinct pathology in neonatal hypoxic-ischemic injury
    Christopher C Leonardo
    Department of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, University of South Florida, Tampa, Florida, USA
    J Neurosci Res 86:1106-14. 2008
    ..The main objectives of this study were to examine the expression profiles of brevican and versican in rat using a standard H-I model and to determine whether altered expression was associated with ..