Arg2

Summary

Gene Symbol: Arg2
Description: arginase 2
Alias: arginase-2, mitochondrial, AII type II arginase, arginase II, arginase type II, kidney-type arginase, non-hepatic arginase, type II arginase
Species: rat

Top Publications

  1. ncbi Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line
    T Gotoh
    Department of Molecular Genetics, Kumamoto University School of Medicine, Japan
    FEBS Lett 395:119-22. 1996
  2. pmc Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus
    J Pernow
    Division of Cardiology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Br J Pharmacol 172:4684-98. 2015
  3. doi Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia
    Akina Nara
    1 Department of Forensic Medicine, Graduate School of Medicine and
    Am J Respir Cell Mol Biol 53:184-92. 2015
  4. doi Arginase inhibition reduces interleukin-1β-stimulated vascular smooth muscle cell proliferation by increasing nitric oxide synthase-dependent nitric oxide production
    Jeongyeon Yoon
    Department of Biology, College of Natural Sciences, Kangwon National University, Chuncheon, Republic of Korea
    Biochem Biophys Res Commun 435:428-33. 2013
  5. ncbi Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts
    Dirk Lindemann
    Institut für Pharmakologie und Toxikologie der Universität Bonn, Reuterstrasse 2b, 53113 Bonn, Germany
    Naunyn Schmiedebergs Arch Pharmacol 368:546-50. 2003
  6. pmc Arginase-2 mediates diabetic renal injury
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:3015-22. 2011
  7. pmc Role of arginase in impairing relaxation of lung parenchyma of hyperoxia-exposed neonatal rats
    Nuzhat K M Ali
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106 6009, USA
    Neonatology 101:106-15. 2012
  8. doi Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
    Mehnaz Khan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Medicine, Tower 711, 600 N Wolfe St, Baltimore, MD 21287, USA
    Eur J Appl Physiol 112:2933-41. 2012
  9. doi Arginine availability modulates arginine metabolism and TNFα production in peritoneal macrophages from Zucker Diabetic Fatty rats
    Charlotte Breuillard
    Laboratory of Nutrition Biology, EA 4466, Paris Descartes University, France
    Clin Nutr 31:415-21. 2012
  10. doi Immunohistochemical study of arginase 1 and 2 in various tissues of rats
    Sungyoung Choi
    Laboratory of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Republic of Korea
    Acta Histochem 114:487-94. 2012

Scientific Experts

  • Srdjan Ljubisavljević
  • J Belik
  • Hakan Erbas
  • V Holan
  • John Albert Watts
  • Celine Demougeot
  • Calvin D Tormanen
  • Jose M Moran
  • Judith M Vonk
  • Idit F Schwartz
  • Oliver Schnorr
  • Mine Erişir
  • Markus Munder
  • Vasthi Lopez
  • Teddy Bagnost
  • Sungwoo Ryoo
  • Mehnaz Khan
  • Jochen Steppan
  • J Pernow
  • Akina Nara
  • Jeongyeon Yoon
  • Charlotte Breuillard
  • Nuzhat K M Ali
  • Sungyoung Choi
  • Donia Amrouni
  • Sidney M Morris
  • Robert A Johnson
  • Wei Zhang
  • Artin A Shoukas
  • Dan E Berkowitz
  • Daniel Nyhan
  • Lakshmi Santhanam
  • Karl H Schuleri
  • Alain Berthelot
  • Claire André
  • Yves Guillaume
  • Masataka Mori
  • Hironori Kanda
  • Tomomi Gotoh
  • Misako Hirata
  • Huiling Li
  • C P Jenkinson
  • Hamid Moradi
  • Itzhak Nissim
  • Hanzhong Liu
  • Myriam Gharbi
  • Ping Liu
  • Bas W M van Balkom
  • Olivier Levillain
  • Naohito Ishii
  • Dirk Lindemann
  • Nives Zimmermann
  • Shalini Thakran
  • Kaori Shintani-Ishida
  • Y Tratsiakovich
  • Ichiro Kuwahira
  • Mikiyasu Shirai
  • Ken ichi Yoshida
  • Sayoko Ogura
  • B Climent
  • Hisashi Nagai
  • A Kiss
  • Tatsuo Shimosawa
  • Chang Li Wei
  • Loretta G Que
  • Sachiyo Iwata
  • Nathalie Neveux
  • Anjum Jafri
  • Richard J Martin
  • Taekyun Shin
  • Jun Hwa Lee
  • H Li
  • Marie Céline Blanc-Quintin
  • Meejung Ahn
  • Karl Schuleri
  • Jean Pascal De Bandt
  • Sylviane Darquy
  • Y S Prakash
  • Tal Berkowitz
  • Syed I A Zaidi
  • Changnam Park
  • Eric Tuday
  • Linda Belabed
  • Sandra Bonhomme
  • Ramadan B Sopi
  • Remy Couderc
  • S Klasen
  • Luc Cynober
  • Lukasz Bugaj
  • Ting Gao

Detail Information

Publications54

  1. ncbi Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line
    T Gotoh
    Department of Molecular Genetics, Kumamoto University School of Medicine, Japan
    FEBS Lett 395:119-22. 1996
    ..almost exclusively in the liver and catalyzes the last step of urea synthesis, whereas the nonhepatic type (arginase II) is expressed in extrahepatic tissues...
  2. pmc Tissue-specific up-regulation of arginase I and II induced by p38 MAPK mediates endothelial dysfunction in type 1 diabetes mellitus
    J Pernow
    Division of Cardiology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Br J Pharmacol 172:4684-98. 2015
    ..Activated p38 MAPK has been reported to increase arginase II in various cardiovascular diseases...
  3. doi Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia
    Akina Nara
    1 Department of Forensic Medicine, Graduate School of Medicine and
    Am J Respir Cell Mol Biol 53:184-92. 2015
    ..IH also increased arginase I expression in the pulmonary artery endothelium and arginase II in the pulmonary artery adventitia...
  4. doi Arginase inhibition reduces interleukin-1β-stimulated vascular smooth muscle cell proliferation by increasing nitric oxide synthase-dependent nitric oxide production
    Jeongyeon Yoon
    Department of Biology, College of Natural Sciences, Kangwon National University, Chuncheon, Republic of Korea
    Biochem Biophys Res Commun 435:428-33. 2013
    ..In conclusion, arginase inhibition augmented iNOS-dependent NO production that resulted in suppression of IL-1β-induced VSMCs proliferation in a cGMP-dependent manner...
  5. ncbi Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts
    Dirk Lindemann
    Institut für Pharmakologie und Toxikologie der Universität Bonn, Reuterstrasse 2b, 53113 Bonn, Germany
    Naunyn Schmiedebergs Arch Pharmacol 368:546-50. 2003
    ..Using RT-PCR mRNA for arginase I was clearly detectable with 30 PCR cycles, whereas mRNA for arginase II was hardly detectable with 35 PCR cycles...
  6. pmc Arginase-2 mediates diabetic renal injury
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:3015-22. 2011
    ..To determine 1) whether renal arginase activity or expression is increased in diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN)...
  7. pmc Role of arginase in impairing relaxation of lung parenchyma of hyperoxia-exposed neonatal rats
    Nuzhat K M Ali
    Department of Pediatrics, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, Ohio 44106 6009, USA
    Neonatology 101:106-15. 2012
    ..We have previously demonstrated that neonatal exposure of rat pups to ≥95% O2 impairs airway relaxation due to disruption of nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling...
  8. doi Upregulation of arginase-II contributes to decreased age-related myocardial contractile reserve
    Mehnaz Khan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University Medicine, Tower 711, 600 N Wolfe St, Baltimore, MD 21287, USA
    Eur J Appl Physiol 112:2933-41. 2012
    ..4,014 ± 314 RFU/min/mg protein, p = 0.005). Arg-II upregulation in aging rat hearts contributes to age-related decreased contractile function...
  9. doi Arginine availability modulates arginine metabolism and TNFα production in peritoneal macrophages from Zucker Diabetic Fatty rats
    Charlotte Breuillard
    Laboratory of Nutrition Biology, EA 4466, Paris Descartes University, France
    Clin Nutr 31:415-21. 2012
    ....
  10. doi Immunohistochemical study of arginase 1 and 2 in various tissues of rats
    Sungyoung Choi
    Laboratory of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Republic of Korea
    Acta Histochem 114:487-94. 2012
    ..These findings indicate that the levels of arginase 1 and 2 varied among organs, suggesting that the arginase isoforms may play organ-specific roles in the urea cycle...
  11. doi Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis
    Srdjan Ljubisavljević
    Clinic of Neurology, University Clinical Centre of Nis, Bul Dr Zorana Djindjica 48, 18000 Nis, Serbia
    J Neurol Sci 318:106-11. 2012
    ..The continued research of these findings may provide a new area in the treatment of multiple sclerosis acute phase...
  12. ncbi Involvement of arginase in regulating myometrial contractions during gestation in the rat
    Misako Hirata
    Comprehensive Reproductive Medicine and Department of Biosystem Regulation, Institute of Biomaterials and Bioengineering, Graduate School, Tokyo Medical and Dental University, 2 3 10 Surugadai, Kanda, Chiyoda ku, Tokyo 101 0062, Japan
    Mol Hum Reprod 12:513-8. 2006
    ..However, the protein was clearly up-regulated at term gestation (22nd day), although arginase II protein was down-regulated during gestation, with the lowest value on the 14th day...
  13. ncbi Effect of chronic renal failure on arginase and argininosuccinate synthetase expression
    Hamid Moradi
    Division of Nephrology and Hypertension, University of California, Irvine, CA 92868, USA
    Am J Nephrol 26:310-8. 2006
    ..L-arg is converted to urea by arginase I in the liver and arginase II in the kidney...
  14. ncbi Time course of vascular arginase expression and activity in spontaneously hypertensive rats
    Celine Demougeot
    Laboratoire de Physiologie, Pharmacologie, Nutrition Preventive Experimentale, Equipe Optimisation Métabolique et Cellulaire, 25030 Besancon, France
    Life Sci 80:1128-34. 2007
    ..Arginase activity as well as expression of arginase I, arginase II, endothelial and inducible NOS were determined in aortic tissue extracts...
  15. ncbi Downregulation of arginase II and renal apoptosis by inorganic mercury: overexpression of arginase II reduces its apoptosis
    Hironori Kanda
    University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Arch Toxicol 82:67-73. 2008
    Inorganic mercury is a toxic metal that accumulates in the proximal tubules of the kidney, causing apoptosis. Arginase II is known to inhibit apoptosis, but its role in the renal apoptosis caused by inorganic mercury is poorly understood...
  16. doi Developmental changes in arginase expression and activity in the lung
    Jaques Belik
    Department of Pediatrics, Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, and University of Toronto, 555 University Ave, Toronto, Ontario, M5G 1X8 Canada
    Am J Physiol Lung Cell Mol Physiol 294:L498-504. 2008
    ..b>Arginase II content, as well as total arginase activity, was highest in fetal rat lung, bronchi, and pulmonary arterial ..
  17. doi Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo
    Oliver Schnorr
    Institute for Biochemistry and Molecular Biology I, Building 22 03, Heinrich Heine University Duesseldorf, Universitaetsstrasse 1, D 40225 Duesseldorf, Germany
    Arch Biochem Biophys 476:211-5. 2008
    ..Dietary intervention with flavanol-rich cocoa caused diminished arginase activity in rat kidney and, erythrocyte arginase activity was lowered in healthy humans following consumption of a high flavanol beverage in vivo...
  18. doi Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat
    Teddy Bagnost
    Laboratory of Physiology, Pharmacology, Experimental Preventive Nutrition, EA 3921, Cellular and Metabolic Optimization, Faculty of Medicine and Pharmacy, Besancon University Hospital, Besancon, France
    J Hypertens 26:1110-8. 2008
    ..The present study investigated the effects of in-vivo arginase inhibition on blood pressure and vascular function in adult spontaneously hypertensive rats...
  19. doi Arginine transport is augmented, through modulation of cationic amino acid transporter-1, in obstructive uropathy in rats
    Idit F Schwartz
    Nephrology Department, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
    Kidney Blood Press Res 31:210-6. 2008
    ..Since availability of L-arginine, the sole precursor for NO, governs NO synthesis, we aimed to determine the role of glomerular arginine transport in rats subjected to 24 h of bilateral ureteral ligation (BUO)...
  20. doi Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats
    Teddy Bagnost
    Laboratoire de Physiologie Pharmacologie Nutrition Préventive Expérimentale, Besancon, France
    Hypertens Res 32:1130-5. 2009
    ..In conclusion, this study shows that increased arginase activity is not restricted to large vessels in SHRs and suggests that cardiac arginase activity is hemodynamic sensitive...
  21. pmc Arginase: an emerging key player in the mammalian immune system
    Markus Munder
    Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany
    Br J Pharmacol 158:638-51. 2009
    ..Pharmacological interference with L-arginine metabolism is a novel promising strategy in the treatment of cancer, autoimmunity or unwanted immune deviation...
  22. doi Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia
    Vasthi Lopez
    Instituto de Estudios de la Salud, Universidad Arturo Prat, Iquique, Chile
    High Alt Med Biol 10:373-81. 2009
    ..596, p < 0.001). An upregulation of arginase type II could be pivotal in understanding the pathogenesis of systolic hypertension and probably other phenomena ..
  23. doi Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response
    Judith M Vonk
    Department of Epidemiology, University Medical Center Groningen, The Netherlands
    Pharmacogenet Genomics 20:179-86. 2010
    ..Arginase probably plays an important role in asthma development, severity and progression. Polymorphisms in arginase 1 and arginase 2 genes have been associated with childhood asthma and FEV1 reversibility to beta2 agonists...
  24. doi Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells
    Jose M Moran
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Departamento de Bioquimica y Biologia Molecular y Genetica, EU Enfermería y TO, Universidad de Extremadura, Avda Universidad s n 10071 Cáceres, Spain
    Nitric Oxide 23:51-9. 2010
    ..of nitric oxide and its potential role in paraquat-induced gene expression, we examined changes in GCH1, ARG1, ARG2, NOS1, NOS2, NOS3, NOSTRIN, NOSIP, NOS1AP, RASD1, DYNLL1, GUCY1A3, DDAH1, DDAH2 and CYGB genes whose expression is ..
  25. doi Vascular arginase contributes to arteriolar endothelial dysfunction in a rat model of hemorrhagic shock
    Robert A Johnson
    Division of Trauma and Emergency Surgery, Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    J Trauma 69:384-91. 2010
    ..However, the role of arginase in hemorrhage-induced endothelial dysfunction has not been studied. This study tests the hypothesis that arginase inhibition improves endothelial function after hemorrhage...
  26. doi Hyperlipidemic versus healthy pancreases: a proteomic analysis using an animal model
    Wei Zhang
    Department of Gastroenterology, Hua Dong Hospital, Fu Dan University School of Medical Sciences, Shanghai, China
    IUBMB Life 62:781-9. 2010
    ..Alpha-amylase and arginase II were dysregulated by more than twofold...
  27. doi Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism
    John A Watts
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
    Pulm Pharmacol Ther 24:407-13. 2011
    ..We tested if experimental PE impairs pulmonary vascular endothelium-dependent dilation via activation of arginase II. Experimental PE was induced in male Sprague-Dawley rats by infusing 25 μm microspheres in the right jugular ..
  28. pmc Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness
    Donia Amrouni
    Universite Claude Bernard Lyon 1, Faculte de Medecine, EA 4170 and Plateau NeuroChem, Lyon, France
    PLoS ONE 6:e16891. 2011
    ....
  29. ncbi Oral administration of orthovanadate and Trigonella foenum graecum seed power restore the activities of mitochondrial enzymes in tissues of alloxan-induced diabetic rats
    Shalini Thakran
    Hormone and Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Mol Cell Biochem 247:45-53. 2003
    ....
  30. ncbi Cloning and characterization of the mouse and rat type II arginase genes
    R K Iyer
    Department of Pathology, UCLA School of Medicine, California 90095, USA
    Mol Genet Metab 63:168-75. 1998
    ..In these patients, a second extrahepatic or type II arginase activity is significantly increased, an induction that may partially compensate for the lack of AI activity ..
  31. ncbi Differential expression of arginase and iNOS in the lung in sepsis
    M S Carraway
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Lung Res 24:253-68. 1998
    ..We found by Western blot that arginase II at 39 kDa was the main isoform present in normal rat lung...
  32. ncbi The human arginases and arginase deficiency
    R Iyer
    Department of Pathology, University of California, Los Angeles, USA
    J Inherit Metab Dis 21:86-100. 1998
    ..The evidence for the role of AII in nitric oxide and polyamine metabolism is presented and this appears consonant with the data on the tissue distribution...
  33. ncbi Induction of arginase isoforms in the lung during hyperoxia
    L G Que
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol 275:L96-102. 1998
    ..The strong expression of arginase in the connective tissues suggests that the function of pulmonary arginase may be linked to connective tissue elements, e.g., fibroblasts, during lung injury and recovery...
  34. ncbi Expression of arginase II and related enzymes in the rat small intestine and kidney
    M Ozaki
    Department of Molecular Genetics, Kumamoto University School of Medicine, Honjo, Kumamoto, 860 0811, Japan
    J Biochem 125:586-93. 1999
    ..conversion of arginine to urea and ornithine, and consists of a liver-type (arginase I) and a non-hepatic type (arginase II)...
  35. ncbi Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells
    H Li
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Am J Physiol Endocrinol Metab 280:E75-82. 2001
    ..transfected with the Escherichia coli lacZ gene (lacZ-EC, control), rat arginase I cDNA (AI-EC), or mouse arginase II cDNA (AII-EC)...
  36. pmc Glucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophages
    S Klasen
    Institut fur Pharmakologie und Toxikologie, Rheinische Friedrich Wilhelms Universitat, Reuterstr 2b, D 53113 Bonn, Germany
    Br J Pharmacol 132:1349-57. 2001
    ..Both, LPS and IFN-gamma enhanced the levels of arginase II mRNA and protein, effects also inhibited by dexamethasone...
  37. ncbi Effects of arginase isoforms on NO Production by nNOS
    Loretta G Que
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Nitric Oxide 6:1-8. 2002
    ..These results suggest that, in 293nNOS cells, AI was more effective in regulating NO production by nNOS, most likely by competing for L-arginine...
  38. ncbi Induction of arginase II in livers of bile duct-ligated rats
    Chang Li Wei
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, Singapore
    Biochem Pharmacol 63:1043-50. 2002
    ..21 x 10(4) attomole/microg of total RNA, sham vs. BDL, P<0.001), as well as arginase I protein. In contrast, arginase II mRNA was induced in the livers of BDL rats, with negligible expression in controls (0.35+/-0.11 vs. 3.64+/-0...
  39. ncbi Decreased expression of arginase II in the kidneys of Dahl salt-sensitive rats
    Sachiyo Iwata
    Department of Internal Medicine, Kobe University Graduate School of Medical Science, Japan
    Hypertens Res 25:411-8. 2002
    ..b>Arginase II (the dominant isoform in the kidney) mRNA and protein in the kidney of salt-loaded SS rats were also lower than ..
  40. ncbi L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats
    Idit F Schwartz
    The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Kidney Int 62:1700-6. 2002
    ..We hypothesized that the increased NO production observed in iARF may result from increased l-Arg uptake, which would be reflected in the augmented expression of l-Arg transporter(s)...
  41. pmc Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis
    Nives Zimmermann
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Clin Invest 111:1863-74. 2003
    ..related to metabolism of basic amino acids, specifically the cationic amino acid transporter 2, arginase I, and arginase II, were particularly prominent among the asthma signature genes...
  42. ncbi Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity, and L-arginine metabolism
    Vladimir Holan
    Institute of Molecular Genetics, Academy of Sciences, and Faculty of Natural Sciences, Charles University, Prague, Czech Republic
    Transplantation 81:1708-15. 2006
    ..Although high levels of NO are generated during allograft rejection, undetectable or only limited amounts of NO were found in rejected skin xenografts...
  43. ncbi Proteomic analysis of long-term vasopressin action in the inner medullary collecting duct of the Brattleboro rat
    Bas W M van Balkom
    Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Am J Physiol Renal Physiol 286:F216-24. 2004
    ..to a role for vasopressin in the coordinate regulation of several determinants of nitric oxide levels (NOS2, arginase II, NADPH oxidase) and of proteins potentially involved in vasopressin escape (adenylyl cyclase VI and G protein-..
  44. ncbi Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid
    Mine Erişir
    Department of Biochemistry, Veterinary Faculty of Firat Euphrates University, Elazig 23119, Turkey
    Cell Biochem Funct 21:331-5. 2003
    ..Vitamin E and Se in combination may prevent the changes in arginase activity in various tissues caused by prednisolone...
  45. ncbi Ornithine metabolism in male and female rat kidney: mitochondrial expression of ornithine aminotransferase and arginase II
    Olivier Levillain
    Laboratoire de Physiopathologie Métabolique et Rénale, Faculté de Médecine Lyon R T H Laennec, INSERM U 499, 7 ue G Paradin, 69372 Lyon Cedex 08, France
    Am J Physiol Renal Physiol 286:F727-38. 2004
    ..is reabsorbed along the proximal convoluted tubule (PCT), transported by basolateral carriers, and produced by arginase II (AII). Here, the renal metabolic fate of L-ornithine was analyzed in male and female rats...
  46. ncbi High glucose augments arginase activity and nitric oxide production in the renal cortex
    Naohito Ishii
    Department of Clinical Chemistry, Kitasato University School of Allied Health Sciences, Kanagawa, Japan
    Metabolism 53:868-74. 2004
    ..These results suggest that increased NOS activity, rather than altered substrate availability, may be the principal factor underlying increased NO synthesis in diabetic kidneys...
  47. ncbi Effects of N-acetylcysteine on arginase, ornithine and nitric oxide in renal ischemia-reperfusion injury
    Hakan Erbas
    Department of Biochemistry, Faculty of Medicine, University of Trakya, 22030 Edirne, Turkey
    Pharmacol Res 50:523-7. 2004
    ..The aim of this study was to investigate the possible effects of NAC on liver and kidney tissue arginase activity, ornithine and plasma nitric oxide levels during the I/R injury of kidney...
  48. ncbi Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: a link to deficits in object recognition?
    Ping Liu
    Vestibular Research Group, Dept of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    J Vestib Res 14:411-7. 2004
    ..plasticity, neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), arginase I and arginase II (AI and II), in the rat EC and PRC using Western blotting...
  49. ncbi The role of mitochondrially bound arginase in the regulation of urea synthesis: studies with [U-15N4]arginine, isolated mitochondria, and perfused rat liver
    Itzhak Nissim
    Children s Hospital of Philadelphia, Division of Child Development and Rehabilitation Medicine, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:17715-24. 2005
    ....
  50. ncbi Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway
    Hanzhong Liu
    Department of Pediatrics, University of Florida, Gainesville, 32610, USA
    Am J Transplant 5:1256-63. 2005
    ..These results suggest that pirfenidone inhibits local arginase activity possibly through suppression of endogenous TGF-beta, hence, limiting the development of fibrosis in lung allografts...
  51. ncbi Modulation of intestinal urea cycle by dietary spermine in suckling rat
    Myriam Gharbi
    Department of Biochemistry and General Physiology, Immunology Center, University of Liege, Belgium
    Biochem Biophys Res Commun 336:1119-24. 2005
    ..Modulation of the gene expression for several urea cycle enzymes suggests a coordination between all the pathway steps and switch toward polyamine (or proline and glutamate) biosynthesis from ornithine...
  52. pmc Genetic polymorphisms in arginase I and II and childhood asthma and atopy
    Huiling Li
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Allergy Clin Immunol 117:119-26. 2006
    A recent microarray study implicated arginase I (ARG1) and arginase II (ARG2) in mouse allergic asthma models and human asthma.
  53. pmc Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism
    Jochen Steppan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Proc Natl Acad Sci U S A 103:4759-64. 2006
    ..These findings have implications for therapy in pathophysiologic states such as aging and heart failure in which myocardial NO signaling is disrupted...
  54. ncbi Inhibition of rat liver and kidney arginase by cadmium ion
    Calvin D Tormanen
    Department of Chemistry, Central Michigan University, Mount Pleasant 48859, USA
    J Enzyme Inhib Med Chem 21:119-23. 2006
    ..Cadmium ion prevented the substrate inhibition of rat kidney arginase by fluoride while still inhibiting the enzyme. Cadmium ion also inhibited rat kidney arginase in the presence of manganese ion...