Aqp4

Summary

Gene Symbol: Aqp4
Description: aquaporin 4
Alias: AQP-4, Miwc, WCH4, aquaporin-4, mercurial-insensitive water channel
Species: rat

Top Publications

  1. doi The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury
    Tetsuhiro Higashida
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosurg 114:92-101. 2011
  2. doi Potential contribution of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage
    Zhong Wang
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, People s Republic of China
    J Mol Neurosci 48:273-80. 2012
  3. doi Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model
    Leena Paul
    Burnett School of Biomedical Science, College of Medicine, University of Central Florida Orlando, Florida, USA
    Neurosurgery 68:462-73. 2011
  4. doi Differential regulations of AQP4 and Kir4.1 by triamcinolone acetonide and dexamethasone in the healthy and inflamed retina
    Min Zhao
    Institut National de la Santé et de la Recherche Médicale U872, Team 17, Physiopathology of ocular diseases therapeutic innovations, Paris, France
    Invest Ophthalmol Vis Sci 52:6340-7. 2011
  5. doi Intraperitoneal administration of Shiga toxin 2 induced neuronal alterations and reduced the expression levels of aquaporin 1 and aquaporin 4 in rat brain
    María Soledad Lucero
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Microb Pathog 53:87-94. 2012
  6. ncbi Expression of glucose transporter-1 and aquaporin-4 in the cerebral cortex of stroke-prone spontaneously hypertensive rats in relation to the blood-brain barrier function
    Hiroyuki Ishida
    Department of Pathology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    Am J Hypertens 19:33-9. 2006
  7. doi Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy
    Kjell Heuser
    Department of Neurology, Rikshospitalet University Hospital, Oslo, Norway
    Epilepsy Res 88:55-64. 2010
  8. ncbi Expression of aquaporin 1 and aquaporin 4 water channels in rat choroid plexus
    Tracey Speake
    School of Biological Sciences, University of Manchester, UK
    Biochim Biophys Acta 1609:80-6. 2003
  9. pmc Aquaporin 1 - a novel player in spinal cord injury
    O Nesic
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 1072, USA
    J Neurochem 105:628-40. 2008
  10. ncbi Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues
    H Hasegawa
    Department of Medicine and Physiology, University of California, San Francisco 94143 0532
    J Biol Chem 269:5497-500. 1994

Research Grants

  1. Vestibular Pathology in Meniere's Disease
    Akira Ishiyama; Fiscal Year: 2007
  2. MOLECULAR PHYSIOLOGY AND STRUCTURE OF AQUAPORINS
    Alfred Van Hoek; Fiscal Year: 2002
  3. NEURONAL MIGRATION IN THE DEVELOPING BRAIN
    Huaiyu Hu; Fiscal Year: 2003
  4. Molecular Studies of Brain Malformations
    Huaiyu Hu; Fiscal Year: 2007
  5. Spectrum of Autoimmune Gastrointestinal Dysmotility
    Vanda Lennon; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. doi The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury
    Tetsuhiro Higashida
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurosurg 114:92-101. 2011
    ....
  2. doi Potential contribution of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage
    Zhong Wang
    Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, People s Republic of China
    J Mol Neurosci 48:273-80. 2012
    ..Pharmacological intervention of this pathway in patients with SAH may provide a novel therapeutic strategy for early brain injury...
  3. doi Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model
    Leena Paul
    Burnett School of Biomedical Science, College of Medicine, University of Central Florida Orlando, Florida, USA
    Neurosurgery 68:462-73. 2011
    ..AQP1 is a water channel found in the choroid plexus (CP), and AQP4 is expressed at the brain-CSF interfaces and astrocytic end feet; excessive fluid accumulation may involve ..
  4. doi Differential regulations of AQP4 and Kir4.1 by triamcinolone acetonide and dexamethasone in the healthy and inflamed retina
    Min Zhao
    Institut National de la Santé et de la Recherche Médicale U872, Team 17, Physiopathology of ocular diseases therapeutic innovations, Paris, France
    Invest Ophthalmol Vis Sci 52:6340-7. 2011
    ..1 and aquaporin-4 (AQP4), the two main retinal Müller glial (RMG) channels controlling retinal fluid movement.
  5. doi Intraperitoneal administration of Shiga toxin 2 induced neuronal alterations and reduced the expression levels of aquaporin 1 and aquaporin 4 in rat brain
    María Soledad Lucero
    Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Microb Pathog 53:87-94. 2012
    ..Neuronal damage, as well as significant decrease in aquaporin 1 (AQP1) and aquaporin 4 (AQP4) expression levels were observed in the brain of rats, 2 days after sStx2 injection, compared to controls...
  6. ncbi Expression of glucose transporter-1 and aquaporin-4 in the cerebral cortex of stroke-prone spontaneously hypertensive rats in relation to the blood-brain barrier function
    Hiroyuki Ishida
    Department of Pathology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
    Am J Hypertens 19:33-9. 2006
    ..of increases in vascular permeability in the cerebral cortex, we investigated the expression of glucose transporter-1 (GLUT-1) in endothelial cells and aquaporin-4 (AQP4) in astrocytes in relation to blood-brain barrier (BBB) function.
  7. doi Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy
    Kjell Heuser
    Department of Neurology, Rikshospitalet University Hospital, Oslo, Norway
    Epilepsy Res 88:55-64. 2010
    ..It has been proposed that the water channel aquaporin-4 (AQP4) and the potassium channel Kir4...
  8. ncbi Expression of aquaporin 1 and aquaporin 4 water channels in rat choroid plexus
    Tracey Speake
    School of Biological Sciences, University of Manchester, UK
    Biochim Biophys Acta 1609:80-6. 2003
    ..Western analysis and immunocytochemistry were used to examine the expression of aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in the rat choroid plexus epithelium...
  9. pmc Aquaporin 1 - a novel player in spinal cord injury
    O Nesic
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 1072, USA
    J Neurochem 105:628-40. 2008
    ....
  10. ncbi Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues
    H Hasegawa
    Department of Medicine and Physiology, University of California, San Francisco 94143 0532
    J Biol Chem 269:5497-500. 1994
    ..water permeability in lung alveolus, we cloned a 32-kDa water channel (mercurial-insensitive water channel (MIWC)) from a rat lung cDNA library with several novel features...
  11. pmc Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance
    J S Jung
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 91:13052-6. 1994
    ..pattern implicates this fourth mammalian member of the aquaporin water channel family (designated gene symbol, AQP4) as the osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
  12. ncbi Select types of supporting cell in the inner ear express aquaporin-4 water channel protein
    Y Takumi
    Department of Anatomy, University of Oslo, Norway
    Eur J Neurosci 10:3584-95. 1998
    ..In contrast, AQP4 protein and mRNA (visualized by in situ hybridization) were concentrated in select types of supporting cell, ..
  13. ncbi Impaired hearing in mice lacking aquaporin-4 water channels
    J Li
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 276:31233-7. 2001
    ..Using mice deficient in selected aquaporins as controls, we localized AQP1 in fibrocytes in the spiral ligament and AQP4 in supporting epithelial cells (Hensen's, Claudius, and inner sulcus cells) in the organ of Corti...
  14. ncbi Decreased hemispheric Aquaporin-4 is linked to evolving brain edema following controlled cortical impact injury in rats
    Karl L Kiening
    Department of Neurosurgery, Virchow Medical Center, Charite, Humboldt University at Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Neurosci Lett 324:105-8. 2002
    The cerebral Aquaporin-4 (AQP4) water channel is suggested to be involved in brain edema formation aggravated by reduced cerebral blood flow early after traumatic brain injury (TBI)...
  15. ncbi Aquaporin 4 expression in the mammalian inner ear and its role in hearing
    Anand N Mhatre
    Laboratory of Molecular Otology, Epstein Laboratories, Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 533 Parnassus Avenue U490A, San Francisco, CA 94143 0526, USA
    Biochem Biophys Res Commun 297:987-96. 2002
    b>Aquaporin 4 (Aqp4), a member of a family of water transport proteins, is a candidate for playing a critical role in inner ear fluid homeostasis...
  16. ncbi Hyperosmolar mannitol simulates expression of aquaporins 4 and 9 through a p38 mitogen-activated protein kinase-dependent pathway in rat astrocytes
    Hajime Arima
    Department of Anesthesia and Critical Care, Okazaki City Hospital, 3 1 Goshoai, Koryuji cho, Okazaki 444 8553, Japan
    J Biol Chem 278:44525-34. 2003
    ..However, the mechanisms regulating the expression of AQP4 and AQP9 induced by hyperosmotic stress are poorly understood...
  17. ncbi Increased aquaporin-4 expression in ammonia-treated cultured astrocytes
    K V Rama Rao
    Department of Pathology, University of Miami School of Medicine, FL 33101, USA
    Neuroreport 14:2379-82. 2003
    ..AQP-4 may be involved in the astrocyte swelling associated with hyperammonemic states...
  18. ncbi Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells
    Claudia Silberstein
    Renal Unit and Program in Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 287:F501-11. 2004
    Aquaporin-4 (AQP4) water channels exist as heterotetramers of M1 and M23 splice variants and appear to be present in orthogonal arrays of intramembraneous particles (OAPs) visualized by freeze-fracture microscopy...
  19. ncbi Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis
    Marios C Papadopoulos
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 280:13906-12. 2005
    The astroglial water channel aquaporin-4 (AQP4) facilitates water movement into and out of brain parenchyma...
  20. ncbi New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43
    Grazia P Nicchia
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
    FASEB J 19:1674-6. 2005
    Aquaporin-4 (AQP4), the main water channel in the brain, is expressed in the perivascular membranes of mouse, rat, and human astrocytes...
  21. ncbi Implications of the aquaporin-4 structure on array formation and cell adhesion
    Yoko Hiroaki
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Kyoto 606 8502, Japan
    J Mol Biol 355:628-39. 2006
    Aquaporin-4 (AQP4) is the predominant water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder and mesial temporal lobe epilepsy...
  22. ncbi Interleukin-1beta induces the expression of aquaporin-4 through a nuclear factor-kappaB pathway in rat astrocytes
    Hiroaki Ito
    Department of Anesthesiology and Medical Crisis Management, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    J Neurochem 99:107-18. 2006
    ..Aquaporin (AQP)4 is also reported to be involved in the progression of brain edema. We tested the hypothesis that AQP4 is induced in response to IL-1beta...
  23. pmc Differential expression of Kir4.1 and aquaporin 4 in the retina from endotoxin-induced uveitis rat
    Xiao Qiang Liu
    Department of Ophthalmology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Mol Vis 13:309-17. 2007
    The inwardly rectifying potassium channel protein Kir4.1 and the water channel protein aquaporin-4 (AQP4) have been suggested to play essential roles in the potassium and water homeostasis of the retina...
  24. ncbi Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions
    K Tanaka
    Department of Neurology, Brain Research Institute, Niigata University, Niigata Japan
    Mult Scler 13:850-5. 2007
    ..Recently, Lennon et al. discovered that NMO-IgG, shown to bind to aquaporin 4 (AQP4), could be a specific marker of NMO and also of Japanese OSMS whose clinical features were identical to ..
  25. ncbi Diabetes alters the localization of glial aquaporins in rat retina
    Ianors Iandiev
    Translational Center for Regenerative Medicine, University of Leipzig, 04103 Leipzig, Germany
    Neurosci Lett 421:132-6. 2007
    ..We investigated whether the immunolocalization of two water channels, AQP1 and AQP4, alters in the rat retina during experimental diabetes...
  26. ncbi Distribution of aquaporin 4 on sarcolemma of fast-twitch skeletal myofibres
    Mika Kaakinen
    Department of Anatomy and Cell Biology, University of Oulu, PO Box 5000, FIN 90014 Oulu, Finland
    Cell Tissue Res 329:529-39. 2007
    The aquaporin 4 (AQP4) water channel is present on the sarcolemma of fast-twitch-type skeletal myofibres...
  27. pmc Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody
    Masami Tanaka
    MS Centre, Utano National Hospital, Kyoto, Japan
    J Neurol Neurosurg Psychiatry 78:990-2. 2007
    Anti-aquaporin 4 (AQP4) antibodies were found in patients with neuromyelitis optica (NMO) and Japanese optic-spinal multiple sclerosis (OSMS).
  28. doi New isoforms of rat Aquaporin-4
    Svein Erik Moe
    Center for Molecular Biology and Neuroscience, University of Oslo, Oslo, Norway
    Genomics 91:367-77. 2008
    Aquaporin-4 (AQP4) is a brain aquaporin implicated in the pathophysiology of numerous clinical conditions including brain edema. Here we show that rat AQP4 has six cDNA isoforms, formed by alternative splicing...
  29. pmc Changes in ocular aquaporin-4 (AQP4) expression following retinal injury
    Adnan Dibas
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, TX, USA
    Mol Vis 14:1770-83. 2008
    ..This study was designed to analyze changes in the expression of AQP4 following elevation of intraocular pressure (IOP) and after intravitreal endothelin-1 injection and the potential ..
  30. pmc Age-related hearing loss: aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain
    Nathan Christensen
    Otolaryngology Department, University of Rochester Medical School, Rochester, NY 14642 8629, USA
    Brain Res 1253:27-34. 2009
    ..Aquaporins, particularly aquaporin 4 (Aqp4), are membrane proteins with important roles in water and ion flux across cell membranes, including cells ..
  31. pmc Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo
    Kumar Sripathirathan
    CoMentis Inc, Oklahoma City, Oklahoma, USA
    J Neurotrauma 26:261-73. 2009
    ..a carbonic anhydrase inhibitor/diuretic with negligible ORAC effectiveness and, interestingly, an aquaporin-4 (AQP4) water channel inhibitor, prevented alcohol-dependent tissue edema and neurodegeneration in HEC slice cultures...
  32. doi High-salt loading exacerbates increased retinal content of aquaporins AQP1 and AQP4 in rats with diabetic retinopathy
    Yaowu Qin
    EENT Hospital, Eye Institute, Fudan University, Fengyang Road 83, Shanghai 200031, China
    Exp Eye Res 89:741-7. 2009
    ..Retinal content and immunolocalization of two water channels, AQP1 and AQP4, in the diabetic rat retinas during high-salt loading were examined in this study...
  33. doi Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats
    Masahide Fukuda
    Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Exp Eye Res 90:17-25. 2010
    ..AQP1 was expressed in the outer retina, whereas AQP4 was expressed in the perivascular and end feet of Müller cells and astrocytes in the inner retina in the control ..
  34. pmc Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice
    Samira Saadoun
    St George s, University of London, London SW17 0RE, UK
    Brain 133:349-61. 2010
    ..In our mouse model, immunoglobulin G from neuromyelitis optica patients does not require pre-existing central nervous system inflammation to produce lesions...
  35. doi Higher order structure of aquaporin-4
    G P Nicchia
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, I 70126 Bari, Italy
    Neuroscience 168:903-14. 2010
    Unlike other mammalian AQPs, multiple tetramers of AQP4 associate in the plasma membrane to form peculiar structures called Orthogonal Arrays of Particles (OAPs), that are observable by freeze-fracture electron microscopy (FFEM)...
  36. pmc Changes in ocular aquaporin expression following optic nerve crush
    Adnan Dibas
    Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA
    Mol Vis 16:330-40. 2010
    ..This study was designed to analyze changes in the expression of AQP4 (water selective channel) and AQP9 (water and lactate channel) following ONC in the rat.
  37. doi Aquaporin-4 astrocytopathy in Baló's disease
    Takeshi Matsuoka
    Department of Neuropathology, Kyushu University, Higashi ku, Fukuoka, Japan
    Acta Neuropathol 120:651-60. 2010
    ..Because selective loss of aquaporin-4 (AQP4) and vasculocentric deposition of complement and immunoglobulins are characteristic in NMO, we aimed to assess AQP4 ..
  38. pmc Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference
    Jerome Badaut
    Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California 92350, USA
    J Cereb Blood Flow Metab 31:819-31. 2011
    ..Because of this critical role and the recognition that brain AQP4 is distributed within astrocytic cell membranes, we hypothesized that AQP4 contributes to the regulation of water ..
  39. pmc Identification of two major conformational aquaporin-4 epitopes for neuromyelitis optica autoantibody binding
    Francesco Pisani
    Department of General and Environmental Physiology, Centre of Excellence in Comparative Genomics, University of Bari, I 70126 Bari, Italy
    J Biol Chem 286:9216-24. 2011
    Neuromyelitis optica (NMO) is an autoimmune demyelinating disease characterized by the presence of anti-aquaporin-4 (AQP4) antibodies in the patient sera...
  40. doi Translational regulation mechanisms of aquaporin-4 supramolecular organization in astrocytes
    Francesco Pisani
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
    Glia 59:1923-32. 2011
    The two predominant isoforms of Aquaporin-4 (AQP4), AQP4-M23 and AQP4-M1, assemble in the plasma membrane to form supramolecular structures called Orthogonal Array of Particles (OAPs) whose dimension is tightly associated to the M1/M23 ..
  41. doi Aquaporin 4 knockdown exacerbates streptozotocin-induced diabetic retinopathy through aggravating inflammatory response
    Bei Cui
    Department of Ophthalmology, First Affiliated Hospital of Second Military Medical University, Shanghai 200433, China
    Exp Eye Res 98:37-43. 2012
    ..Diabetes is known to alter the amount of retinal expression of the water-selective channels aquaporin 4 (AQP4). However, the function and impact of AQP4 in diabetic retinopathy is not well understood...
  42. doi Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies
    Grazia Paola Nicchia
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
    Glia 57:1363-73. 2009
    ..in autoantibodies produced by patients with NMO (NMO-IgG) recognize a glial water channel protein, Aquaporin-4 (AQP4) expressed as two major isoforms, M1- and M23-AQP4, in which the plasma membrane form orthogonal arrays of ..
  43. doi Combustion smoke exposure induces up-regulated expression of vascular endothelial growth factor, aquaporin 4, nitric oxide synthases and vascular permeability in the retina of adult rats
    Y Y Zou
    Department of Pathology, Faculty of Basic Medical Sciences, Kunming Medical College, Kunming, People s Republic of China
    Neuroscience 160:698-709. 2009
    ..The major changes included up-regulated expression of vascular endothelial growth factor (VEGF), aquaporin 4 (AQP4) and nitric oxide synthase (NOS)...
  44. pmc IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
    Vanda A Lennon
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Exp Med 202:473-7. 2005
    ..NMO may represent the first example of a novel class of autoimmune channelopathy...
  45. doi Formation of aquaporin-4 arrays is inhibited by palmitoylation of N-terminal cysteine residues
    Hiroshi Suzuki
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo, Kyoto 606 8502, Japan
    Biochim Biophys Acta 1778:1181-9. 2008
    Tetramers of the mammalian water channel aquaporin-4 (AQP4) assemble into square arrays and mediate bidirectional water transport across the blood-brain interface. The aqp4 gene expresses two splicing isoforms...
  46. doi Vasopressin-dependent short-term regulation of aquaporin 4 expressed in Xenopus oocytes
    H B Moeller
    Department of Anatomy, Nordic Center of Excellence for Water Imbalance Related Disorders, The Water and Salt Research Center, University of Aarhus, Aarhus, Denmark
    Neuroscience 164:1674-84. 2009
    b>Aquaporin 4 (AQP4) is abundantly expressed in the perivascular glial endfeet in the central nervous system (CNS), where it is involved in the exchange of fluids between blood and brain...
  47. doi Favorable effects of MMP-9 knockdown in murine herpes simplex encephalitis using small interfering RNA
    Yu Zhou
    Department of Neurology, Renmin Hospital of Wuhan University, China
    Neurol Res 32:801-9. 2010
    ..We hypothesize that temporally knockdown MMP-9 expression in early phase of HSE might be an effective treatment strategy...
  48. doi The relationship between aquaporin-4 expression and blood-brain and spinal cord barrier permeability following experimental autoimmune encephalomyelitis in the rat
    Xiang Nan Huang
    Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, People s Republic of China
    Anat Rec (Hoboken) 294:46-54. 2011
    b>Aquaporin 4(AQP4) is a water channel protein strongly expressed in the central nervous system in perimicrovessel astrocyte foot processes, the glia limitans, and ependyma...
  49. ncbi [Deficiency of water channel AQP4 aggravates NMDA-induced brain injury in mice]
    Wen Zhen Shi
    Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310058, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 40:145-9. 2011
    To evaluate the role of water channel AQP4 in NMDA-induced brain injury in mice.
  50. ncbi [Role of P38 signaling pathway in neonatal rat astrocyte swelling and aquaporin-4 expression after oxygen-glucose deprivation and recovery]
    Zhaohua Tang
    Department of Neurosurgery, Chongqing Medical University, Chongqing, China
    Nan Fang Yi Ke Da Xue Xue Bao 32:141-5. 2012
    To explore the role of P38 signaling pathway in neonatal rat astrocyte swelling and the expression of aquaporin-4 (AQP4) after oxygen-glucose deprivation (OGD) and recovery (OGD/R).
  51. doi Protective effects of erythropoietin on astrocytic swelling after oxygen-glucose deprivation and reoxygenation: mediation through AQP4 expression and MAPK pathway
    Zhaohua Tang
    Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, No 1 Youyi Road, Chongqing 400016, China
    Neuropharmacology 67:8-15. 2013
    ..by reoxygenation (OGD/Reox) in vitro and whether this effect can be mediated through the modulation of aquaporin4 (AQP4) expression in the plasma membrane (PM) and phosphorylation of the mitogen-activated protein kinase pathway (MAPK) ..
  52. doi Increased expression of Aquaporin 4 in the rat hippocampus and cortex during trimethyltin-induced neurodegeneration
    S Ceccariglia
    Institute of Anatomy and Cell Biology, Universita Cattolica del Sacro Cuore, L go F Vito 1, 00168 Rome, Italy
    Neuroscience 274:273-88. 2014
    ..b>Aquaporin 4 (AQP4), a glial water channel protein expressed mainly in the nervous system, is considered a specific marker ..
  53. doi Loss of AQP4 polarized localization with loss of β-dystroglycan immunoreactivity may induce brain edema following intracerebral hemorrhage
    Guo ping Qiu
    Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, People s Republic of China
    Neurosci Lett 588:42-8. 2015
    The aquaporin-4 (AQP4) water channel contributes to brain water homeostasis in perivascular and subpial membrane domains of astrocytes where it is concentrated...
  54. doi Aquaporins and blood-brain barrier permeability in early edema development after traumatic brain injury
    Jonas Blixt
    Department of Anesthesiology and Intensive Care, Karolinska University Hospital, Karolinska Institutet, SE 171 77 Stockholm, Sweden Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden Electronic address
    Brain Res 1611:18-28. 2015
    ..The total amount of AQP4 protein decreased (-20%)...
  55. doi Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na⁺/H⁺ exchanger 1 expression
    Ryutaro Nishioka
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Japan
    Exp Neurol 277:150-61. 2016
    ..Exercise prevented the ischemia-induced expression of mRNA encoding aquaporin 4 (AQP4) and Na(+)/H(+) exchangers (NHEs) (n=5 or 7, P<0.01)...
  56. ncbi [A aquaporin 4 expression and effects in rat hippocampus after microwave radiation]
    Xiang Li
    Institution of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 27:534-8. 2009
    To investigate the expression of aquaporin 4 (AQP4) after microwave exposure and the correlation with the brain injury by radiation.
  57. doi Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats
    Daniele Tomassoni
    Anatomia Umana, Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universita di Camerino, Camerino, Italy
    Brain Res 1325:155-63. 2010
    ..AQP1 is expressed in the apical membrane of choroid plexus epithelium. AQP4 is expressed by astrocyte foot processes near blood vessels...
  58. doi Anti-aquaporin-4 antibodies in the context of assorted immune-mediated diseases
    A Dellavance
    Research and Development Division, Fleury Group, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brasil
    Eur J Neurol 19:248-52. 2012
    Anti-aquaporin 4 antibodies are specific markers for Devic's disease. This study aimed to test if this high specificity holds in the context of a large spectrum of systemic autoimmune and non-autoimmune diseases.
  59. doi Regulation of AQP4 surface expression via vesicle mobility in astrocytes
    Maja Potokar
    Laboratory of Neuroendocrinology Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Glia 61:917-28. 2013
    b>Aquaporin 4 (AQP4) is the predominant water channel in the brain, expressed mainly in astrocytes and involved in water transport in physiologic and pathologic conditions...
  60. doi Brain expression of the water channels aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema
    Martin Eefsen
    Department of Hepatology, Rigshospitalet, University Hospital of Copenhagen, Blegdamsvej 9, Copenhagen, Denmark
    Metab Brain Dis 25:315-23. 2010
    ..The water channels Aquaporin-1 (Aqp1) and -4 (Aqp4) has been associated with brain edema formation in several neuropathological conditions, indicating a possible role ..
  61. pmc AQP4-dependent water transport plays a functional role in exercise-induced skeletal muscle adaptations
    Davide Basco
    Department of Bioscience, Biotechnologies and Biopharmaceutics and Center of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
    PLoS ONE 8:e58712. 2013
    In this study we assess the functional role of Aquaporin-4 (AQP4) in the skeletal muscle by analyzing whether physical activity modulates AQP4 expression and whether the absence of AQP4 has an effect on osmotic behavior, muscle ..
  62. pmc Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy
    Parham Moftakhar
    Department of Radiology and Biomedical Imaging, UCSF Medical Center, San Francisco, CA, USA
    J Neuropathol Exp Neurol 69:1201-9. 2010
    ..We investigated the expression of aquaporin 1 (AQP1) and aquaporin 4 (AQP4) in 24 human autopsy brains consisting of 18 with AD and varying degrees of CAA and 6 with no pathologic ..
  63. doi p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage
    Jun hao Yan
    Department of Anatomy and Embryology, School of Basic Medical Sciences, Peking University, Beijing, China
    CNS Neurosci Ther 18:334-42. 2012
    ..To investigate the mechanism behind cytotoxic edema formation following subarachnoid hemorrhage (SAH)...
  64. doi NFAT5-dependent expression of AQP4 in astrocytes
    Min Hee Yi
    Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, South Korea
    Cell Mol Neurobiol 33:223-32. 2013
    The maintenance of water homeostasis under pathological conditions is mediated by the aquaporin-4 (AQP4) channel in astrocytes...
  65. doi Short-term effect of erythropoietin on brain lesions and aquaporin-4 expression in a hypoxic-ischemic neonatal rat model assessed by magnetic resonance diffusion weighted imaging and immunohistochemistry
    Olivier Brissaud
    Neonatal Intensive Care Unit, University Children s Hospital, Bordeaux 33076, France
    Pediatr Res 68:123-7. 2010
    ..underlying the effects of Epo, immunohistochemical detection of caspase-3 and water channel protein aquaporin-4 (AQP4) were performed...
  66. ncbi Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain
    Tetsuhiro Higashida
    Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 8:44-51. 2011
    ..Pharmacological blockade of this pathway in stroke patients may provide novel therapeutic strategies...
  67. doi Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease
    Ying Chi
    Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, China
    Aging Cell 10:368-82. 2011
    Aquaporin-4 (AQP4) is highly expressed in mammalian brains and is involved in the pathophysiology of cerebral disorders, including stroke, tumors, infections, hydrocephalus, epilepsy, and traumatic brain injury...
  68. ncbi [Expression of aquaporin 3, 4, and 8 in colonic mucosa of rat models with slow transit constipation]
    Hui Zhi
    Department of General Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
    Zhonghua Wei Chang Wai Ke Za Zhi 14:459-61. 2011
    ..To investigate the expression of aquaporin 3, 4, and 8 in the colonic mucosa of rat models with slow transit constipation (STC)...
  69. doi Aquaporin-4 expression is not elevated in mild hydrocephalus
    Kamran Aghayev
    Department of Neuro Oncology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, 33612, USA
    Acta Neurochir (Wien) 154:753-9; discussion 759. 2012
    ..Several studies demonstrated its compensatory role in severe hydrocephalus. However, its role is not clear during the initial stages of hydrocephalus...
  70. pmc Delayed increase of astrocytic aquaporin 4 after juvenile traumatic brain injury: possible role in edema resolution?
    A M Fukuda
    Department of Physiology, Loma Linda University, Loma Linda, CA 92354, USA
    Neuroscience 222:366-78. 2012
    ..We examined the spatiotemporal expression pattern of principal brain AQPs (AQP1, AQP4, and AQP9) after juvenile TBI (jTBI) related to edema formation and resolution observed using magnetic resonance ..
  71. doi Small-scale purification and mass spectrometry analysis reveal a third aquaporin-4 protein isoform of 36 kDa in rat brain
    Jan Gunnar Sørbø
    Center for Molecular Biology and Neuroscience CMBN and Nordic Centre for Research on Water Imbalance Related Disorders WIRED, University of Oslo, Norway
    J Neurosci Methods 211:31-9. 2012
    Aquaporin-4 (AQP4) is known to have two main isoforms M1 and M23 in the brain...
  72. doi Ammonia induces aquaporin-4 rearrangement in the plasma membrane of cultured astrocytes
    Guillermo Bodega
    Departamento de Biología Celular y Genética, Facultad de Biologia, Universidad de Alcala, 28871 Alcala de Henares, Madrid, Spain
    Neurochem Int 61:1314-24. 2012
    Aquaporin-4 (AQP4) is a water channel protein mainly located in the astroglial plasma membrane, the precise function of which in the brain edema that accompanies hepatic encephalopathy (HE) is unclear...
  73. ncbi A role of the C-terminus of aquaporin 4 in its membrane expression in cultured astrocytes
    Ken ichi Nakahama
    Department of Anatomy, Kinki University School of Medicine, 377 2 Ohno Higashi, Osakasayama City, Osaka 589 8511, Japan
    Genes Cells 7:731-41. 2002
    b>Aquaporin 4 (AQP4) is a predominant water channel protein in mammalian brains, which is localized in the astrocyte plasma membrane. Membrane targeting of AQP4 is essential to perform its function...
  74. ncbi Impact of experimental acute hyponatremia on severe traumatic brain injury in rats: influences on injuries, permeability of blood-brain barrier, ultrastructural features, and aquaporin-4 expression
    Changshu Ke
    Division of Neurosurgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N T, Hong Kong
    Exp Neurol 178:194-206. 2002
    ..The ultrastructural features were also correlated with the down-regulation of aquaporin-4 (AQP4) mRNA expression (P < 0.05)...
  75. ncbi A method for the comprehensive proteomic analysis of membrane proteins
    Christine C Wu
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Biotechnol 21:532-8. 2003
    ..Furthermore, coupling protease protection strategies to this method permits characterization of the relative sidedness of the hydrophilic domains of membrane proteins...
  76. ncbi Partitioning of aquaporin-4 water channel mRNA and protein in gastric glands
    Yan Huang
    Renal Unit, Program in Membrane Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Dig Dis Sci 48:2027-36. 2003
    Immunolocalization studies in proximal, middle, and distal stomach indicated that aquaporin-4 (AQP4) protein is localized only in parietal cells located in the middle or deep regions of the gastric glands...
  77. ncbi [Expression of aquaporin 1 and aquaporin 4 in rat laryngeal tissue]
    Bing Guan
    Department of Otorhinolaryngology Head and Neck Surgery, China Japan Union Hospital, Jilin University, Changchun, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 20:132-4. 2006
    To detect expression level and distribution of aquaporin 1(AQP1) and aquaporin 4 (AQP4) in rat laryngeal tissues and try to find out significance about aquaporin in the laryngeal function and mechanism on the laryngeal diseases.
  78. pmc Aquaporin-11: a channel protein lacking apparent transport function expressed in brain
    Daniel A Gorelick
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA
    BMC Biochem 7:14. 2006
    ..Two recently described aquaporins, numbers 11 and 12, appear to be more distantly related to the other mammalian aquaporins and aquaglyceroporins...
  79. ncbi Trafficking and phosphorylation dynamics of AQP4 in histamine-treated human gastric cells
    Monica Carmosino
    Department of General and Environmental Physiology, University of Bari, Via Amendola 165 A, 70126 Bari, Italy
    Biol Cell 99:25-36. 2007
    AQP4 (aquaporin 4) internalization and a concomitant decrease in the osmotic water permeability coefficient (Pf) after histamine exposure has been reported in AQP4-transfected gastric HGT1 cells.
  80. ncbi Ischemia-reperfusion alters the immunolocalization of glial aquaporins in rat retina
    Ianors Iandiev
    Paul Flechsig Institute of Brain Research, University of Leipzig Medical Faculty, 04109 Leipzig, Germany
    Neurosci Lett 408:108-12. 2006
    ..we investigated whether ischemia-reperfusion of the rat retina causes alterations in the distribution of AQP1 and AQP4 proteins...
  81. ncbi Different pattern of aquaporin-4 expression in extensor digitorum longus and soleus during early development
    Grazia P Nicchia
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Via Amendola 165 A, I 70126 Bari, Italy
    Muscle Nerve 35:625-31. 2007
    Aquaporin-4 (AQP4) is the neuromuscular water channel expressed at the sarcolemma of mammalian fast-twitch fibers that mediates a high water transport rate, which is important during muscle activity...
  82. ncbi Thrombin inhibits aquaporin 4 expression through protein kinase C-dependent pathway in cultured astrocytes
    Yuping Tang
    Laboratory of Neurology, Institute of Integrative Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China
    J Mol Neurosci 31:83-93. 2007
    b>Aquaporin 4 (AQP4) is a key molecule for maintaining water balance in the central nervous system, and its dysfunction might cause brain edema. However, little is known about the regulation of AQP4 expression...
  83. ncbi Distinct detergent-resistant membrane microdomains (lipid rafts) respectively harvest K(+) and water transport systems in brain astroglia
    Hiroshi Hibino
    Division of Molecular and Cellular Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Eur J Neurosci 26:2539-55. 2007
    ..K(+)-buffering inwardly rectifying Kir4.1 channels and the water channel AQP4 are expressed in astrocytes and they may be functionally coupled to maintain ionic and osmotic homeostasis in the ..
  84. doi Actin cytoskeleton remodeling governs aquaporin-4 localization in astrocytes
    Grazia Paola Nicchia
    Department of General and Environmental Physiology, Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
    Glia 56:1755-66. 2008
    Aquaporin-4 (AQP4) is constitutively concentrated in the plasma membrane of the perivascular glial processes, and its expression is altered in certain pathological conditions associated with brain edema or altered glial migration...
  85. doi Bradykinin preconditioning modulates aquaporin-4 expression after spinal cord ischemic injury in rats
    Wei Bing Xu
    Department of Orthopaedics, Dalian Municipal Central Hospital, Da Lian 116033, Liaoning Province, PR China
    Brain Res 1246:11-8. 2008
    The study investigated whether bradykinin (BK) preconditioning could regulate the expression of aquaporin-4 (AQP4) using an in vivo transient spinal cord ischemia model in rats...
  86. pmc Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays
    Alfred N Van Hoek
    Simches Research Center, 8 208, 185 Cambridge St, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 296:F1396-404. 2009
    Aquaporin-4 (AQP4) is a basolateral water channel in collecting duct principal cells and assembles into orthogonal array particles (OAPs), the size of which appears to depend on relative expression levels of AQP4 splice variants...
  87. pmc Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes
    Geoffroy Noel
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver V6T 1Z3, Canada
    J Biol Chem 284:19694-704. 2009
    ..with perivascular laminin in the targeting of the dystrophin complex and the water-permeable channel, aquaporin 4 (AQP4), at astrocyte endfeet...
  88. pmc The protein kinase C activator phorbol myristate acetate decreases brain edema by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat
    Giovanna Fazzina
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298 0508, USA
    J Neurotrauma 27:453-61. 2010
    The protein kinase C activator phorbol 12-myristate 13-acetate (PMA) is known to interact with aquaporin 4 (AQP 4), a water-selective transporting protein that is abundant in astrocytes, and has experimentally been found to decrease ..
  89. pmc Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells
    Jonathan M Crane
    Departments of Medicine and Physiology, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:35850-60. 2009
    Aquaporin-4 (AQP4) can assemble into supramolecular aggregates called orthogonal arrays of particles (OAPs)...
  90. doi Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation
    Sheng Mei Zhu
    Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hang Zhou 310003, People s Republic of China
    Anesth Analg 109:1493-9. 2009
    b>Aquaporin 4 (AQP4) plays a key role in maintaining water balance in the central nervous system, and its dysfunction may lead to brain edema...
  91. doi Decreases in rat brain aquaporin-4 expression following intracerebroventricular administration of an endothelin ET B receptor agonist
    Yutaka Koyama
    Laboratory of Pharmacology, Faculty of Pharmacy, Osaka Ohtani University, 3 11 1 Nishikiori kita, Tonda bayashi, Osaka 584 8540, Japan
    Neurosci Lett 469:343-7. 2010
    ..In the cerebrum, the copy numbers of AQP4 mRNAs were highest among AQP1, 3, 4, 5 and 9...
  92. doi Temporal profiles of aquaporin 4 expression and astrocyte response in the process of brain damage in fat embolism model in rats
    Toru Gohara
    Department of Anesthesiology, Yamaguchi University Graduate School of Medicine, 1 1 1 Minami kogushi, Ube, Yamaguchi, 755 8505, Japan
    J Anesth 24:225-33. 2010
    ..We investigated brain damage in relationship to temporal profiles of water channel aquaporin 4 (AQP4) and astrocyte response to fat embolism in rats.
  93. pmc Aquaporin expression in blood-retinal barrier cells during experimental autoimmune uveitis
    Elie Motulsky
    Laboratory of Biological Chemistry and Nutrition, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Vis 16:602-10. 2010
    ..We have therefore evaluated the expression of AQP1 and AQP4 on BRB cells during experimental autoimmune uveitis (EAU) in mice.
  94. doi Role of aquaporin-4 in the development of brain oedema in liver failure
    Gavin Wright
    Institute of Hepatology, University College London, London, UK
    J Hepatol 53:91-7. 2010
    ..We aimed to determine whether aquaporin-4 (AQP4), an astrocyte endfeet bi-directional water channel, is associated with the brain oedema of HE.
  95. ncbi Immunohistochemical localization of aquaporin-4 in the rat pituitary gland
    Sachi Kuwahara
    Department of Anatomy and Cell Biology, Hyogo College of Medicine, Mukogawa cho, Nishinomiya, Hyogo, Japan
    J Vet Med Sci 72:1307-12. 2010
    Aquaporin-4 (AQP4) is an isoform of membrane water channel aquaporins. It is most abundant in the brain, and is believed to be expressed by astrocytes and ependymal cells...
  96. doi Protective role of aquaporin-4 water channels after contusion spinal cord injury
    Atsushi Kimura
    Department of Neurological Surgery, University of California, Irvine, CA, USA
    Ann Neurol 67:794-801. 2010
    ..However, the mechanisms that control edema and the extent to which edema impacts outcome after SCI are not well elucidated...
  97. doi Müller cells upregulate the expression of SAP97 in light-injured rat retina
    Hui Ren
    EENT Hospital, Eye Institute, Shanghai, China
    Neuroreport 21:832-6. 2010
    ..upregulated and concentrated in the Müller cell processes after photic injury, which was similar to the changes of AQP4 and the inwardly rectifying potassium channel, Kir4.1...
  98. doi Aquaporin-4 water channel oligomers are associated with the transverse tubules of skeletal myofibers
    Mika Kaakinen
    Institute of Biomedicine, Department of Anatomy and Cell Biology, P O Box 5000, FIN 90014, University of Oulu, Oulu, Finland
    Exp Cell Res 317:20-8. 2011
    ..Here we have examined whether the T tubules contain aquaporin type 4 (AQP4) water channels to mediate rapid transmembrane water flow...
  99. pmc Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
    Hironaka Igarashi
    Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh ku, Niigata, 951 8585, Japan
    Neurol Sci 32:113-6. 2011
    We investigated the in vivo effects of a novel aquaporin 4 (AQP4) inhibitor 2-(nicotinamide)-1,3,4-thiadiazole, TGN-020, in a mouse model of focal cerebral ischemia using 7.0-T magnetic resonance imaging (MRI)...
  100. ncbi [The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats]
    Shu Nü Cai
    Department of Anesthesiology, Zhejiang Cancer Hospital, Hangzhou 310022, China
    Zhonghua Yi Xue Za Zhi 90:1648-51. 2010
    To investigate the effects of ketamine pretreatment on cerebral edema following brain ischemia reperfusion injury in rats and assess the involvement of Aquaporin 4 (AQP4) expression.

Research Grants5

  1. Vestibular Pathology in Meniere's Disease
    Akira Ishiyama; Fiscal Year: 2007
    ..or with alterations in neuronal number or size? 6) What are the morphometric correlates to abnormalities on traditional vestibular testing: caloric paresis, and decreased gain and time constant on step rotational testing? ..
  2. MOLECULAR PHYSIOLOGY AND STRUCTURE OF AQUAPORINS
    Alfred Van Hoek; Fiscal Year: 2002
    ..of the molecular physiology of solvent/solute transport by functional domain exchange between water selective AQP4 channels and poly-selective AQP9 channels in combination with a scanning site-directed mutagenesis program...
  3. NEURONAL MIGRATION IN THE DEVELOPING BRAIN
    Huaiyu Hu; Fiscal Year: 2003
    ....
  4. Molecular Studies of Brain Malformations
    Huaiyu Hu; Fiscal Year: 2007
    ....
  5. Spectrum of Autoimmune Gastrointestinal Dysmotility
    Vanda Lennon; Fiscal Year: 2009
    ..l.dysmotilities, and justify early consideration of immunomodulatory therapies. The proposed research also has high clinical relevance to cancer immunity. ..