App

Summary

Gene Symbol: App
Description: amyloid beta precursor protein
Alias: Abeta, amyloid beta A4 protein, ABPP, alzheimer disease amyloid A4 protein homolog, amyloid A4, amyloid beta (A4) precursor protein, amyloid precursor protein, amyloidogenic glycoprotein, beta-amyloid precursor protein
Species: rat

Top Publications

  1. pmc Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688
    Amina El Ayadi
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 109:13416-21. 2012
  2. doi Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia
    Takuya Watanabe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Neurosci Res 88:1908-17. 2010
  3. pmc The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells
    Kaoru Yamada
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 283:34554-62. 2008
  4. pmc Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates
    Allen C Chen
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:11378-91. 2010
  5. ncbi Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity
    Jaroslaw Kanski
    Department of Chemistry, University of Kentucky, Lexington 40506 0055, USA
    Biochim Biophys Acta 1586:190-8. 2002
  6. pmc The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
    J P Borg
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109, USA
    Mol Cell Biol 16:6229-41. 1996
  7. ncbi The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
    X Huang
    Laboratory for Oxidation Biology, Genetics and Aging Unit, Massachusetts General Hospital, Charlestown 02129, USA
    Biochemistry 38:7609-16. 1999
  8. ncbi Expression of c-Fos and c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noise
    Annette Säljö
    Department of Anatomy and Cell Biology, University of Goteborg, Sweden
    J Neurotrauma 19:379-85. 2002
  9. ncbi The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo
    Shasta L Sabo
    Laboratory of Molecular and Cellular Neuroscience and the Zachary and Elizabeth M Fisher Center, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 23:5407-15. 2003
  10. ncbi Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex
    John J Dougherty
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Neurosci 23:6740-7. 2003

Scientific Experts

Detail Information

Publications126 found, 100 shown here

  1. pmc Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688
    Amina El Ayadi
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Proc Natl Acad Sci U S A 109:13416-21. 2012
    The pathogenesis of Alzheimer's disease (AD) is associated with proteolytic processing of the amyloid precursor protein (APP) to an amyloidogenic peptide termed Aβ...
  2. doi Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia
    Takuya Watanabe
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Neurosci Res 88:1908-17. 2010
    Alzheimer's disease (AD) is progressive dementia with senile plaques composed of beta-amyloid (Abeta). Recent studies suggest that synaptic dysfunction is one of the earliest events in the pathogenesis of AD...
  3. pmc The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells
    Kaoru Yamada
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 283:34554-62. 2008
    ....
  4. pmc Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates
    Allen C Chen
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:11378-91. 2010
    ..of Alzheimer disease by excising the hydrophobic, aggregation-prone amyloid beta-peptide from the beta-amyloid precursor protein. A central unresolved question is how its many substrates bind and enter the gamma-secretase complex...
  5. ncbi Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity
    Jaroslaw Kanski
    Department of Chemistry, University of Kentucky, Lexington 40506 0055, USA
    Biochim Biophys Acta 1586:190-8. 2002
    Recent theoretical calculations predicted that Gly33 of one molecule of amyloid beta-peptide (1-42) (Abeta(1-42)) is attacked by a putative sulfur-based free radical of methionine residue 35 of an adjacent peptide...
  6. pmc The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
    J P Borg
    Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109, USA
    Mol Cell Biol 16:6229-41. 1996
    ..of X11 and one of the PI domains of FE65, two neuronal proteins, bind to the cytoplasmic domain of the amyloid precursor protein ((beta)APP). (beta)APP is an integral transmembrane glycoprotein whose cellular function is unknown...
  7. ncbi The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
    X Huang
    Laboratory for Oxidation Biology, Genetics and Aging Unit, Massachusetts General Hospital, Charlestown 02129, USA
    Biochemistry 38:7609-16. 1999
    ..These findings indicate that the accumulation of A beta could be a direct source of oxidative stress in Alzheimer's disease...
  8. ncbi Expression of c-Fos and c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noise
    Annette Säljö
    Department of Anatomy and Cell Biology, University of Goteborg, Sweden
    J Neurotrauma 19:379-85. 2002
    ..Here, rat brains were investigated immunohistochemically for the expression of c-Fos, c-Myc, and beta-APP during the first 3 weeks postexposure to impulse noise of 198 or 202 dB...
  9. ncbi The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo
    Shasta L Sabo
    Laboratory of Molecular and Cellular Neuroscience and the Zachary and Elizabeth M Fisher Center, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 23:5407-15. 2003
    Although the Alzheimer amyloid protein precursor (APP) has been studied intensely for more than a decade, its function in neurons is unresolved. Much less is known about its binding partner FE65...
  10. ncbi Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex
    John J Dougherty
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    J Neurosci 23:6740-7. 2003
    Alteration by beta-amyloid (Abeta) of signaling via nicotinic acetylcholine receptors (nAChRs) has been implicated in the early stages of Alzheimer's disease...
  11. ncbi DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3
    Donna L McPhie
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 23:6914-27. 2003
    ..We show that expression of familial AD (FAD) mutants of the amyloid precursor protein (APP) in primary neurons in culture causes apoptosis and DNA synthesis...
  12. pmc Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage
    Angela Ho
    The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, NA4 118, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 101:2548-53. 2004
    Amyloid-beta precursor protein (APP), a type I membrane protein, is physiologically processed by alpha- or beta-secretases that cleave APP N-terminal to the transmembrane region...
  13. ncbi Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease
    Bryan Maloney
    Departments of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    FASEB J 18:1288-90. 2004
    Potentially toxic amyloid beta-peptide (Abeta) in Alzheimer's disease (AD) is generated from a family of Abeta-containing precursor proteins (APP), which is regulated via the 5'-untranslated region (5'-UTR) of its mRNA...
  14. ncbi The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain
    M Riyaz Basha
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island 02881, USA
    J Neurosci 25:823-9. 2005
    ..by excessive deposits of aggregated beta-amyloid (Abeta) peptides, which are snippets of the beta-amyloid precursor protein (APP)...
  15. ncbi ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
    Young Hae Chong
    Department of Microbiology, College of Medicine, Division of Molecular Biology and Neuroscience, Ewha Medical Research Institute, Ewha Womans University, Yangcheonku, Seoul, 158 710, Korea
    J Biol Chem 281:20315-25. 2006
    ..investigated the molecular basis for the altered signal transduction associated with soluble amyloid beta-protein (Abeta) oligomer-mediated neurotoxicity in the hippocampus, which is primarily linked to cognitive dysfunction in ..
  16. ncbi Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides
    Claire Goldsbury
    Max Planck Unit for Structural Molecular Biology, c o DESY, Notkestrasse 85, 22607 Hamburg, Germany
    Traffic 7:873-88. 2006
    Amyloid-beta, a peptide derived from the precursor protein APP, accumulates in the brain and contributes to the neuropathology of Alzheimer's disease...
  17. ncbi Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice
    Celina V Zerbinatti
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:36180-6. 2006
    ..protein (LRP) is highly expressed in the brain and has been shown to alter the metabolism of amyloid precursor protein and amyloid-beta peptide (Abeta) in vitro...
  18. ncbi The cell-selective neurotoxicity of the Alzheimer's Abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for Abeta toxicity
    Olga Simakova
    Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    J Neurosci 27:13719-29. 2007
    Measurement of Abeta toxicity of cells in culture exposes a subpopulation of cells with resistance to Abeta, even at high concentrations and after long periods of treatment...
  19. pmc Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    Ganesh M Shankar
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 14:837-42. 2008
    ..We extracted soluble amyloid-beta protein (Abeta) oligomers directly from the cerebral cortex of subjects with Alzheimer's disease...
  20. pmc The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity
    Asad Jan
    Laboratory of Molecular Neurobiology and Neuroproteomics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 283:28176-89. 2008
    Aggregation and fibril formation of amyloid-beta (Abeta) peptides Abeta40 and Abeta42 are central events in the pathogenesis of Alzheimer disease...
  21. pmc Interaction of reelin with amyloid precursor protein promotes neurite outgrowth
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057 1464, USA
    J Neurosci 29:7459-73. 2009
    The processing of amyloid precursor protein (APP) to Abeta is an important event in the pathogenesis of Alzheimer's disease, but the physiological function of APP is not well understood...
  22. doi Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses
    Efrat Abramov
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nat Neurosci 12:1567-76. 2009
    Accumulation of cerebral amyloid-beta peptide (Abeta) is essential for developing synaptic and cognitive deficits in Alzheimer's disease...
  23. pmc Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers
    Ali Reza A Ladiwala
    Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    J Biol Chem 285:24228-37. 2010
    ..Surprisingly, resveratrol does not remodel non-toxic oligomers or accelerate Abeta monomer aggregation despite that both conformers possess random coil secondary structures indistinguishable from ..
  24. pmc ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1
    Ragna Sannerud
    Laboratory of Membrane Trafficking, Center for Human Genetics, Catholic University of Leuven, Leuven, Belgium
    Proc Natl Acad Sci U S A 108:E559-68. 2011
    ..and a hallmark in Alzheimer's disease pathology, are generated through the sequential cleavage of amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase...
  25. pmc Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling
    Ottavio V Vitolo
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain and Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:13217-21. 2002
    ..In the studies reported here we demonstrate that amyloid beta-peptide (Abeta) treatment of cultured hippocampal neurons leads to the inactivation of protein kinase A (PKA) and persistence of ..
  26. ncbi Glutamate and amyloid beta-protein rapidly inhibit fast axonal transport in cultured rat hippocampal neurons by different mechanisms
    Hiromi Hiruma
    Department of Physiology, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    J Neurosci 23:8967-77. 2003
    Impairment of axonal transport leads to neurodegeneration and synapse loss. Glutamate and amyloid beta-protein (Abeta) have critical roles in the pathogenesis of Alzheimer's disease (AD)...
  27. pmc Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production
    Alessio Vagnoni
    KCL Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Hum Mol Genet 21:2845-54. 2012
    Understanding the mechanisms that control processing of the amyloid precursor protein (APP) to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research...
  28. ncbi A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein
    T Watanabe
    Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021, USA
    J Neurochem 72:549-56. 1999
    Alzheimer amyloid precursor protein (APP) is an integral membrane protein with a short cytoplasmic domain of 47 amino acids...
  29. ncbi Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles
    Jinoh Kim
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California 94720, USA
    J Biol Chem 280:7758-68. 2005
    Mutant forms of presenilin (PS) 1 and 2 and amyloid precursor protein (APP) lead to familial Alzheimer's disease. Several reports indicate that PS may modulate APP export from the endoplasmic reticulum (ER)...
  30. pmc APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells
    Giovanna De Chiara
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e13989. 2010
    ..neurotoxic peptides, which occurs during amyloidogenic endoproteolytic processing of the transmembrane amyloid precursor protein (APP)...
  31. ncbi Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons
    SeungYong Yoon
    Department of Anatomy and Cell Biology, University of Ulsan College of Medicine, Seoul, Korea
    Neuroreport 18:1879-83. 2007
    ..b>Amyloid precursor protein (APP) is the precursor protein of the beta-amyloid peptide that accumulates in extracellular plaques in ..
  32. ncbi Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein
    D Schubert
    Salk Institute for Biological Studies, San Diego, CA 92138
    Science 241:223-6. 1988
    ..The synaptic localization and metabolism of this class of proteoglycans are consistent with its potential involvement in central nervous system dysfunction...
  33. pmc Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation
    R K Lee
    Department of Brain and Cognitive Sciences, E25 604, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 94:5422-6. 1997
    Amyloid plaques in Alzheimer disease are primarily aggregates of Abeta peptides that are derived from the amyloid precursor protein (APP)...
  34. ncbi Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat
    Hideaki Wakita
    Department of Neurology, Faculty of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Brain Res 924:63-70. 2002
    ..Therefore, we examined axonal damage using immunohistochemistry for the amyloid beta/A4 precursor protein (APP), chromogranin A (CgA) and demyelination using immunohistochemistry for the encephalitogenic peptide (EP) in this ..
  35. ncbi Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
    Stephen H Pasternak
    Research Institute, The Hospital for Sick Children, University of Toronto, Toronto M5G 1X8, Canada
    J Biol Chem 278:26687-94. 2003
    ..deposition of beta-amyloid (Abeta), a 38-43-amino acid peptide derived by proteolytic cleavage of the amyloid precursor protein (APP)...
  36. pmc Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease
    Y Wakutani
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurol Neurosurg Psychiatry 75:1039-42. 2004
    To describe a novel missense mutation, Asp678Asn (D678N), in the amyloid precursor protein (APP) gene in a Japanese pedigree of probable familial Alzheimer's disease (FAD).
  37. ncbi Inhibition of Alzheimer's amyloid-beta peptide-induced reduction of mitochondrial membrane potential and neurotoxicity by gelsolin
    Hongjiang Qiao
    The Division of Cancer Gene Regulation, Research Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Neurobiol Aging 26:849-55. 2005
    ..These results demonstrate that cytoplasmic gelsolin plays a important role in inhibiting Abeta-induced cytotoxicity by inhibiting apoptotic mitochondrial changes...
  38. ncbi Amyloid peptide attenuates the proteasome activity in neuronal cells
    Sangsoo Oh
    Neuroscience Program, Ajou University, Suwon, Republic of Korea
    Mech Ageing Dev 126:1292-9. 2005
    ..This study investigated the possibility that the Abeta peptides interact with the ubiquitin-proteasome pathway inside neuronal cells...
  39. ncbi Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels
    Idan Rakover
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Neurodegener Dis 4:392-402. 2007
    ..approach to inhibit Abeta production via antibodies against the beta-secretase cleavage site of the amyloid precursor protein (APP)...
  40. doi Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels
    Ana María Simón
    Division of Neurosciences, CIMA, University of Navarra, Av Pio XII 55, 31008 Pamplona, Spain
    Neurobiol Dis 33:369-78. 2009
    Transgenic mice expressing mutant human amyloid precursor protein (APP) develop an age-dependent amyloid pathology and memory deficits, but no overt neuronal loss...
  41. ncbi Abeta(31-35)-induced neuronal apoptosis is mediated by JNK-dependent extrinsic apoptosis pathway
    Ling Min Li
    Department of Pathology, Shanxi Medical University, Taiyuan, China
    Neurosci Bull 25:361-6. 2009
    To investigate whether JNK-caspase-dependent apoptotic pathway is involved in Abeta(31-35)-induced apoptosis of cultured cortical neurons.
  42. pmc gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes
    Jenny Frånberg
    Karolinska Institutet Alzheimer s Disease Research Center KI ADRC, Department of Neurobiology, Care Sciences and Society NVS, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 5:e9772. 2010
    gamma-Secretase is an intramembrane aspartyl protease whose cleavage of the amyloid precursor protein (APP) generates the amyloid beta-peptide (Abeta) and the APP intracellular domain...
  43. pmc The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons
    Roger S Chung
    NeuroRepair Group, Menzies Research Institute, University of Tasmania, Hobart, Australia
    PLoS ONE 5:e12030. 2010
    A major pathological hallmark of AD is the deposition of insoluble extracellular beta-amyloid (Abeta) plaques. There are compelling data suggesting that Abeta aggregation is catalysed by reaction with the metals zinc and copper.
  44. pmc Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro
    Abhay Moghekar
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 286:15989-97. 2011
    The metabolism of the amyloid precursor protein (APP) has been extensively investigated because its processing generates the amyloid-β-peptide (Aβ), which is a likely cause of Alzheimer disease...
  45. pmc Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein
    Emily S Stieren
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 286:35689-98. 2011
    Alzheimer disease (AD) is associated with extracellular deposition of proteolytic fragments of amyloid precursor protein (APP)...
  46. doi Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures
    I L Ferreira
    CNC Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
    Cell Calcium 51:95-106. 2012
    ..This study contributes to the understanding of the molecular basis of early AD pathogenesis, by exploring the role of GluN2A and GluN2B subunits in the mechanism of Aβ toxicity in AD...
  47. pmc Aβ-40 Y10F increases βfibrils formation but attenuates the neurotoxicity of amyloid-β peptide
    Xueling Dai
    Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing 100191, China E mail
    Int J Mol Sci 13:5324-37. 2012
    ..These findings may lead to further understanding of the structural perturbation of Aβ to its fibrillation...
  48. pmc PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)
    Debomoy K Lahiri
    Laboratory of Molecular Neurogenetics, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA
    BMC Genomics 14:68. 2013
    ..Protein sequence mutations of the Aβ precursor protein (APP) account for a small proportion of AD cases, suggesting that regulation of the associated gene (APP) may play a ..
  49. doi Electromagnetic pulse exposure induces overexpression of beta amyloid protein in rats
    Da Peng Jiang
    Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, Xi an, Shaanxi, China
    Arch Med Res 44:178-84. 2013
    ..Electromagnetic pulse (EMP) is one type of widely used EMF. This study aimed to clarify whether EMP exposure could induce cognitive and memory impairment, thus finding a possible relationship between EMP and AD...
  50. pmc Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance
    Lucas J Sosa
    Department of Pediatrics and Colorado Intellectual and Developmental Disabilities Research Center, University of Colorado School of Medicine, Aurora, Colorado, USA
    PLoS ONE 8:e64521. 2013
    b>Amyloid precursor protein (APP), a transmembrane glycoprotein, is well known for its involvement in the pathogenesis of Alzheimer disease of the aging brain, but its normal function is unclear...
  51. doi β-Amyloid is transmitted via neuronal connections along axonal membranes
    Ha Lim Song
    Alzheimer s Disease Experts Laboratory, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Anatomy and Cell Biology, University of Ulsan College of Medicine, Seoul, Korea Bio medical Institute of Technology, University of Ulsan College of Medicine, Seoul, Korea Cell Dysfunction Research Center, University of Ulsan College of Medicine, Seoul, Korea
    Ann Neurol 75:88-97. 2014
    ..However, there is no direct experimental evidence to show transmission of β-amyloid...
  52. pmc The effects of endogenous non-peptide molecule isatin and hydrogen peroxide on proteomic profiling of rat brain amyloid-β binding proteins: relevance to Alzheimer's disease?
    Alexei E Medvedev
    Department of Proteomic Research and Mass Spectrometry, Institute of Biomedical Chemistry, 10 Pogodinskaya Street, Moscow 119121, Russia
    Int J Mol Sci 16:476-95. 2014
    ....
  53. doi A mouse model of Alzheimer's disease displays increased susceptibility to kindling and seizure-associated death
    Jianxiong Chan
    Department of Medicine RMH, The University of Melbourne, Parkville, Victoria, Australia
    Epilepsia 56:e73-7. 2015
    ..These findings support the "two-hit" hypothesis and represent a potentially novel research model to help better understand the relationship between AD pathology and epilepsy. ..
  54. pmc Differential effect of amyloid β on the cytochrome P450 epoxygenase activity in rat brain
    P Sarkar
    Department of Physiology and Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 194:241-9. 2011
    ..Further understanding of these interactions will improve our ability to protect against the pathology of Alzheimer's disease...
  55. doi The profile of β-amyloid precursor protein expression of rats induced by aluminum
    Xiao Bo Li
    Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
    Environ Toxicol Pharmacol 33:135-40. 2012
    The environmental agent aluminum has been extensively investigated for a potential relationship with amyloid precursor protein (APP) expression...
  56. pmc Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces β-secretase (BACE1) levels and Aβ generation
    Yun Ding
    Department of Medicine, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Biol Chem 287:8424-33. 2012
    The cellular levels of β-site APP cleaving enzyme 1 (BACE1), the rate-limiting enzyme for the generation of the Alzheimer disease (AD) amyloid β-peptide (Aβ), are tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ..
  57. pmc Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons
    Inna Solomonov
    Department of Structural Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 287:20555-64. 2012
    ..Thus, Zn(2+) promotes Aβ40 neurotoxicity by structural organization mechanisms mediated by coordination chemistry...
  58. pmc Cell line specific modulation of extracellular aβ42 by Hsp40
    Anna Carnini
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 7:e37755. 2012
    ..Therefore, increasing Hsp40 therapeutically with the intention of interfering with the pathogenic cascade leading to neurodegeneration in AD should be pursued with caution...
  59. pmc C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity
    Marie E Benoit
    Department of Molecular Biology and Biochemistry, of California at Irvine, Irvine, California 92697, USA
    J Biol Chem 288:654-65. 2013
    ....
  60. pmc Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction
    Erzsebet M Szatmari
    Department of Neurobiology and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Neurosci 33:5367-74. 2013
    ..of Elk-1 with mitochondria were also observed in transgenic mice overexpressing a human mutant form of amyloid precursor protein. Therefore, the CentA1-Ras-Elk-1 signaling pathway acts on mitochondria to regulate dendritic spine ..
  61. ncbi Purification and tissue level of the beta-amyloid peptide precursor of rat brain
    A Potempska
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314
    J Biol Chem 266:8464-9. 1991
    The beta-amyloid peptide precursor (beta-APP) exists in brain tissue as a membrane-associated protein extractable with 1% Triton X-100...
  62. ncbi The beta A4 amyloid precursor protein binding to copper
    L Hesse
    Center for Molecular Biology Heidelberg, University Heidelberg, Germany
    FEBS Lett 349:109-16. 1994
    Previously it has been shown that the extracellular domain of transmembrane beta A4 amyloid precursor protein (APP) includes binding sites for zinc(II) and for molecules of the extracellular matrix such as collagen, laminin and the ..
  63. ncbi Structural features of the 5' upstream regulatory region of the gene encoding rat amyloid precursor protein
    J M Chernak
    Molecular Neurobiology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224
    Gene 133:255-60. 1993
    The 5' upstream regulatory region of the gene encoding the rat amyloid precursor protein (APP) was cloned and sequenced...
  64. ncbi APP gene family. Alternative splicing generates functionally related isoforms
    R Sandbrink
    Zentrum für Molekulare Biologie Heidelberg ZMBH, University of Heidelberg, Germany
    Ann N Y Acad Sci 777:281-7. 1996
    The Alzheimer's beta A4-amyloid protein precursor (APP) and the APP-like proteins (APLPs) are transmembrane glycoproteins with a similar modular domain structure...
  65. ncbi Expression of the APP gene family in brain cells, brain development and aging
    R Sandbrink
    Center for Molecular Biology Heidelberg ZMBH, University of Heidelberg, Germany
    Gerontology 43:119-31. 1997
    The Alzheimer's beta A4-amyloid protein precursor (APP) and the APP-like proteins (APLPs) are transmembrane glycoproteins with a similar modular domain structure...
  66. ncbi The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1
    N Zambrano
    Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, Via S Pansini 5, 80131 Napoli, Italy
    J Biol Chem 273:20128-33. 1998
    ..PID1 and PID2); the most C-terminal of these domains (PID2) interacts in vivo with the Alzheimer's beta-amyloid precursor protein, whereas the WW domain binds to Mena, the mammalian homolog of Drosophila-enabled protein...
  67. ncbi Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region
    K Tsuchida
    Department of Biochemistry, Kobe Pharmaceutical University, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 276:37155-60. 2001
    ..Here we analyzed the CS chain of appican, the CSPG form of the Alzheimer's amyloid precursor protein. Appican is expressed almost exclusively by astrocytes and has been reported to have brain- and ..
  68. ncbi Age-dependent differential regulation of genes encoding APP and alpha-synuclein in hippocampal synaptic plasticity
    A Stephan
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, CNRS UMR 8620, Universite Paris Sud, Orsay, France
    Hippocampus 12:55-62. 2002
    We investigated the modulation of the messenger RNA encoding the amyloid precursor protein (APP) and alpha-synuclein following induction of long-term potentiation (LTP) in the dentate gyrus of young and aged rats...
  69. ncbi Mechanism of membrane depolarization caused by the Alzheimer Abeta1-42 peptide
    Barbara J Blanchard
    Department of Biology, Massachusetts Institute of Technology, 31 Ames Street, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 293:1197-203. 2002
    ..This phenomenon involves activation of the metabotropic glutamate receptor, mGluR(1). Abeta-induced membrane depolarization in PC12 cells is sensitive to mGluR(1) antagonists and to pertussis and cholera ..
  70. ncbi Eliminating membrane depolarization caused by the Alzheimer peptide Abeta(1-42, aggr.)
    Barbara J Blanchard
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 293:1204-8. 2002
    ..We found 10 potentially useful compounds, some of which reduce the Abeta-induced membrane depolarization up to 96%...
  71. ncbi Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?
    Aedin M Minogue
    Trinity College Institute of Neuroscience, Department of Physiology, Trinity College, Dublin 2, Ireland
    J Biol Chem 278:27971-80. 2003
    Amyloid-beta (Abeta) is a major constituent of the neuritic plaque found in the brain of Alzheimer's disease patients, and a great deal of evidence suggests that the neuronal loss that is associated with the disease is a consequence of ..
  72. ncbi Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease
    Kazuma Murakami
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 278:46179-87. 2003
    Cerebral amyloid angiopathy (CAA) due to beta-amyloid (Abeta) is one of the specific pathological features of familial Alzheimer's disease...
  73. ncbi The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis
    Donat Kogel
    Interdisciplinary Center for Clinical Research IZKF, Research Group Apoptosis and Cell Death, University Münster Clinics, Munster, Germany
    J Neurochem 87:248-56. 2003
    ..In the present study, we investigated the effect of the human amyloid precursor protein (APP) on the ER stress response in PC12 cells...
  74. ncbi Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid
    Rodrigo Alarcón
    Department of Neurology, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Marcoleta 391, Santiago, Chile
    J Biol Chem 280:30406-15. 2005
    ..Microglia are activated by and can phagocytose beta-amyloid (Abeta). Scavenger receptors (SRs) are among the receptors mediating the uptake of fibrillar Abeta in vitro...
  75. ncbi SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    Jennifer Chen
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
    J Biol Chem 280:40364-74. 2005
    ..that NF-kappaB signaling in microglia is critically involved in neuronal death induced by amyloid-beta (Abeta) peptides, which are widely presumed to cause Alzheimer disease...
  76. ncbi Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation
    Md Riyaz Basha
    Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    FASEB J 19:2083-4. 2005
    ..of excessive deposits of aggregated beta-amyloid (Abeta) peptides, which are derived from the beta-amyloid precursor protein (APP) following processing by beta-secretase and gamma-secretase...
  77. ncbi [Expression of beta-amyloid precursor protein in diffuse axonal injury of rats]
    Jin long Zhu
    Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Fa Yi Xue Za Zhi 21:165-8. 2005
    To explore an method for diffuse axonal injury (DAI) diagnosis and injury time estimation, the changes of beta-APP immunoreactivity and to observe the morphology of axonal in different parts of brain after experimental DAI injury.
  78. ncbi Nitric oxide synthase inhibitors modulate nerve growth factor-mediated regulation of amyloid precursor protein expression in PC12 cells
    Janet C Binnington
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada
    J Neurochem 101:422-33. 2007
    ..In this study, the role of NO in NGF-stimulated amyloid precursor protein (APP) levels was studied...
  79. ncbi Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies
    Valérie Vingtdeux
    INSERM, U837, Neurodegenerative Disorders and Neuronal Death, Lille, France
    J Biol Chem 282:18197-205. 2007
    b>Amyloid precursor protein (APP) metabolism is central to the pathogenesis of Alzheimer disease...
  80. ncbi Rat's trick to escape Alzheimer's disease
    Lian Shen
    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Center for Advanced Study, Shandong University of Technology, Zibo 255049, P R China
    J Biomol Struct Dyn 25:271-4. 2007
    Amyloid beta (Abeta) peptides fibril formation and deposition is considered to be the principal pathological hallmark of Alzheimer's disease (AD)...
  81. ncbi Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Biol Chem 283:6288-99. 2008
    Dab1 is an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2), increases their levels on the cell surface, and increases their cleavage by alpha-secretases...
  82. doi Phosphorylation of beta-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis
    Chhinder P Sodhi
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Brain Res 1198:204-12. 2008
    ..of beta-amyloid peptides (Abeta) derived by endoproteolytic ("amyloidogenic") processing of beta-amyloid precursor protein (APP) represent collectively an early and necessary event in the pathogenesis of Alzheimer's disease...
  83. doi Modulation of 'A'-type K+ current by rodent and human forms of amyloid beta protein
    Talitha L Kerrigan
    Institutes of aMembrane and Systems Biology bCardiovascular Research, University of Leeds, Leeds, UK
    Neuroreport 19:839-43. 2008
    The Alzheimer's disease related peptide amyloid beta (Abeta) might have a physiological role in upregulating K channel currents in neurones. Earlier studies used the human form of Abeta1-40 on rat neurones...
  84. doi Alpha4beta2 nicotinic acetylcholine receptors are required for the amyloid beta protein-induced suppression of long-term potentiation in rat hippocampal CA1 region in vivo
    M N Wu
    Department of Neurobiology and the national key discipline of physiology, Shanxi Medical University, Taiyuan, Shanxi 030001, PR China
    Brain Res Bull 77:84-90. 2008
    Amyloid beta protein (Abeta) is thought to be responsible for the deficit of learning and memory in Alzheimer's disease (AD), possibly through interfering with synaptic plasticity such as hippocampal long-term potentiation (LTP)...
  85. pmc Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs
    Sara Sanz-Blasco
    Instituto de Biologia y Genetica Molecular, Universidad de Valladolid and Consejo Superior de Investigaciones Cientificas, Valladolid, Spain
    PLoS ONE 3:e2718. 2008
    Dysregulation of intracellular Ca(2+) homeostasis may underlie amyloid beta peptide (Abeta) toxicity in Alzheimer's Disease (AD) but the mechanism is unknown...
  86. pmc NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons
    Carmela Matrone
    Institute of Neurobiology and Molecular Medicine, Consiglio Nazionale delle Ricerche, Via del Fosso di Fiorano 64, 00143 Rome, Italy
    Proc Natl Acad Sci U S A 105:13139-44. 2008
    ..catalytic subunits and of APP C-terminal fragments and a progressive accumulation of intra- and extracellular Abeta aggregates partly released into the culture medium...
  87. doi The APP670/671 mutation alters calcium signaling and response to hyperosmotic stress in rat primary hippocampal neurons
    Ewa Kloskowska
    Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, 14186 Stockholm, Sweden
    Neurosci Lett 444:275-9. 2008
    ..These results suggest that APP670/671 transgenic neurons have impaired calcium homeostasis...
  88. pmc Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription
    Kwok Fai Lau
    Department of Biochemistry and Molecular Biotechnology Programme, Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR
    J Biol Chem 283:34728-37. 2008
    ..protein that binds to and forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain...
  89. doi Intracellular sAPP retention in response to Abeta is mapped to cytoskeleton-associated structures
    Ana Gabriela Henriques
    Laboratorio de Neurociencias, Centro de Biologia Celular, Universidade de Aveiro, Aveiro, Portugal
    J Neurosci Res 87:1449-61. 2009
    ..In the work described here, Abeta did not induce amyloid precursor protein (APP) expression, but APP processing/trafficking was markedly affected...
  90. doi Expression of amyloid precursor protein after rat traumatic brain injury
    Tatsuki Itoh
    Department of Pathology, Kinki University School of Medicine, Okasayyama City, Osaka, Japan
    Neurol Res 31:103-9. 2009
    Previous reports have demonstrated that some focal brain injuries increase amyloid precursor protein (APP) immunoreactivity in the region surrounding the injury in the cerebral cortex...
  91. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
    Accumulation of amyloid beta (Abeta) oligomers in the brain is toxic to synapses and may play an important role in memory loss in Alzheimer disease. However, how these toxins are built up in the brain is not understood...
  92. pmc Mapping cofilin-actin rods in stressed hippocampal slices and the role of cdc42 in amyloid-beta-induced rods
    Richard C Davis
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    J Alzheimers Dis 18:35-50. 2009
    ..Amyloid-beta (Abeta) induces rods predominantly in the dentate gyrus region, and Abeta-induced rods are reversible following washout...
  93. doi Soluble oligomeric forms of beta-amyloid (Abeta) peptide stimulate Abeta production via astrogliosis in the rat brain
    J L Perez
    Laboratory of Neuroanatomy, Institute of Neuroscience of Castilla and Leon, Valladolid University Campus of Soria, Spain
    Exp Neurol 223:410-21. 2010
    The aim of this study was to investigate the interaction between beta-amyloid (Abeta) peptide and astrogliosis in early stages of Abeta toxicity...
  94. doi Changes in cell proliferation in the subventricular zone of the brain in adult rats given beta-amyloid peptide (25-35)
    M Yu Stepanichev
    Laboratory for the Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
    Neurosci Behav Physiol 40:123-6. 2010
    The effects of intracerebroventricular administration of fragment (25-35) of beta-amyloid peptide [Abeta(25-35)] on cell proliferation in the subventricular zone of the dentate gyrus of the hippocampus in adult rats were analyzed...
  95. pmc Amyloid beta from axons and dendrites reduces local spine number and plasticity
    Wei Wei
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 13:190-6. 2010
    Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease. Amyloid beta (Abeta), a peptide secreted in an activity-modulated manner by neurons, has been implicated in the pathogenesis of Alzheimer's ..
  96. doi Possible involvement of NO/NOS signaling in hippocampal amyloid-beta production induced by transient focal cerebral ischemia in aged rats
    Song Li
    Institute of Neuroinformatics, Dalian University of Technology, 116024 Dalian, China
    Neurosci Lett 470:106-10. 2010
    ..The present data may be important in understanding, at least in part, the pathological role of NO/NOS system involved in hippocampal A beta production and neuronal damage induced by transient cerebral ischemia...
  97. pmc MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons
    Elisa Vilardo
    Istituto di Neurobiologia e Medicina Molecolare, CNR, Roma, Italy
    J Biol Chem 285:18344-51. 2010
    The amyloid precursor protein (APP) and its proteolytic product amyloid beta (Abeta) are associated with both familial and sporadic forms of Alzheimer disease (AD). Aberrant expression and function of microRNAs has been observed in AD...
  98. doi Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity
    Sangmi Shim
    Creative Research Initiative CRI Acceleration Research Laboratory, School of Biological Science Bio Max Institute, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul, Korea
    Cell Mol Life Sci 68:2115-27. 2011
    ..These results suggest that up-regulated FOXRED2 inhibits proteasome activity by interfering with 26S proteasome assembly to contribute to Aβ neurotoxicity via an ER stress response...
  99. pmc The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-β
    Hye Eun Han
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    PLoS ONE 5:e15645. 2010
    ..The presence of the same consensus sequence, Val(12)-His-His-Gln(15), near the presumptive α-secretase cleavage site of the amyloid-β (Aβ) peptide led us to hypothesize that NIa could possess activity against Aβ...
  100. doi Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells
    Grzegorz A Czapski
    Department of Cellular Signaling, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawinskiego 5, 02 106 Warsaw, Poland
    FEBS Lett 585:1243-8. 2011
    ..of cyclin dependent kinase 5 (Cdk5) expression and phosphorylation in PC12 cells overexpressing amyloid precursor protein (APP)...
  101. doi The mechanism for heme to prevent Aβ(1-40) aggregation and its cytotoxicity
    Qingui Bao
    Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    J Biol Inorg Chem 16:809-16. 2011
    ..These results indicated that exogenous heme is able to alleviate the cytotoxicity induced by Aβ(1-40) and Cu(2+). This information may be a foundation to develop a potential strategy to treat AD...