apolipoprotein E

Summary

Gene Symbol: apolipoprotein E
Description: apolipoprotein E
Alias: APOEA, apolipoprotein E, apo-E
Species: rat

Top Publications

  1. ncbi Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    S H Zhang
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 258:468-71. 1992
  2. ncbi Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain
    Jillian R Gee
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536 0230, USA
    Biogerontology 7:69-79. 2006
  3. pmc Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
    S Bellosta
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 96:2170-9. 1995
  4. ncbi Regulation of apolipoprotein A-1 and E gene expression in liver and intestine of nephrotic and pair-fed rats
    A Panduro
    Department of Gastroenterology, Instituto Nacional de la Nutricion Salvador Zubiran, Tlalpan, Mexico D F
    Nephron 65:100-7. 1993
  5. pmc Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo
    P C Rensen
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Sylvius Laboratories, 2300 RA Leiden, The Netherlands
    J Clin Invest 99:2438-45. 1997
  6. ncbi Role of apolipoprotein E in lipoprotein metabolism and in the process of atherosclerosis
    N Yamada
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Atheroscler Thromb 2:S29-33. 1995
  7. pmc Herpes simplex encephalitis: involvement of apolipoprotein E genotype
    W R Lin
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
    J Neurol Neurosurg Psychiatry 70:117-9. 2001
  8. ncbi Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors
    Akihiro Hirashiki
    Division of Cardiology, Okazaki City Hospital, Okazaki, Japan
    J Am Coll Cardiol 42:1429-37. 2003
  9. ncbi Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
  10. ncbi Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma
    Thomas Ressiniotis
    Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Mol Vis 10:805-7. 2004

Scientific Experts

Detail Information

Publications107 found, 100 shown here

  1. ncbi Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    S H Zhang
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 258:468-71. 1992
    b>Apolipoprotein E (apoE) is a ligand for receptors that clear remnants of chylomicrons and very low density lipoproteins...
  2. ncbi Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain
    Jillian R Gee
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536 0230, USA
    Biogerontology 7:69-79. 2006
    ..b>Apolipoprotein E (ApoE) is produced in the brain and has been shown to possess anti-inflammatory properties in a variety of ..
  3. pmc Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice
    S Bellosta
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco 94141 9100, USA
    J Clin Invest 96:2170-9. 1995
    ..The data suggest that apoE prevents atherosclerosis by promoting cholesterol efflux from cells of the arterial wall...
  4. ncbi Regulation of apolipoprotein A-1 and E gene expression in liver and intestine of nephrotic and pair-fed rats
    A Panduro
    Department of Gastroenterology, Instituto Nacional de la Nutricion Salvador Zubiran, Tlalpan, Mexico D F
    Nephron 65:100-7. 1993
    ..To study the regulation of apolipoprotein (apo) A-1 and apo E gene expression in nephrotic rats, we analyzed the steady-state levels (SSLs) of hepatic and intestinal apo A-1 ..
  5. pmc Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats In vivo
    P C Rensen
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, Sylvius Laboratories, 2300 RA Leiden, The Netherlands
    J Clin Invest 99:2438-45. 1997
    ..Recently, we developed recombinant chylomicrons from commercially available lipids and human recombinant apolipoprotein E. The current study explored the effectiveness of these apoE-enriched emulsions in redirecting LPS from ..
  6. ncbi Role of apolipoprotein E in lipoprotein metabolism and in the process of atherosclerosis
    N Yamada
    Third Department of Internal Medicine, University of Tokyo, Japan
    J Atheroscler Thromb 2:S29-33. 1995
    b>Apolipoprotein E (apoE) plays an important role in plasma lipoprotein metabolism through its high affinity binding to cell surface low density lipoprotein (LDL) receptor...
  7. pmc Herpes simplex encephalitis: involvement of apolipoprotein E genotype
    W R Lin
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
    J Neurol Neurosurg Psychiatry 70:117-9. 2001
    ..in the brain, is a risk factor for Alzheimer's disease in carriers of the type 4 allele of the gene for apolipoprotein E (apoE epsilon4), and apoE epsilon4 is a risk factor for herpes labialis...
  8. ncbi Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors
    Akihiro Hirashiki
    Division of Cardiology, Okazaki City Hospital, Okazaki, Japan
    J Am Coll Cardiol 42:1429-37. 2003
    ..The aim of the study was to identify genes that confer susceptibility to coronary artery disease (CAD) in low- or high-risk men or women separately and thereby to assess the genetic risk of CAD in such individuals...
  9. ncbi Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
    ..women with this condition; the -863C-->A in the tumor necrosis factor-alpha gene, the -219G-->T in the apolipoprotein E gene, the 1019C-->T in the connexin 37 gene for men without type 2 diabetes; and the -482C-->T in the ..
  10. ncbi Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma
    Thomas Ressiniotis
    Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Mol Vis 10:805-7. 2004
    ..Recent genetic association studies have implicated the apolipoprotein E (APOE) gene in the pathophysiology of primary open angle glaucoma, but there have been conflicting findings.
  11. ncbi Effects of apolipoprotein E genotypes on the development of exfoliation syndrome
    Ayca Yilmaz
    Ophthalmology Department, Mersin University Faculty of Medicine, 33079 Mersin, Turkey
    Exp Eye Res 80:871-5. 2005
    b>Apolipoprotein E (apo E) is directly involved in the amyloid deposition and fibril formation and is present in many cerebral and systemic amyloidoses immunologically...
  12. ncbi The apolipoprotein E gene polymorphism is associated with open angle glaucoma in the Japanese population
    Fumihiko Mabuchi
    Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    Mol Vis 11:609-12. 2005
    To assess whether genetic polymorphisms of the apolipoprotein E (APOE) gene are associated with open angle glaucoma (OAG) in the Japanese population.
  13. ncbi Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin
    E Campalani
    The Dermatology Centre, University of Manchester, Hope Hospital, Manchester, UK
    Br J Dermatol 154:345-52. 2006
    ..Increased lipid levels are also seen in patients with psoriasis treated with acitretin. Apolipoprotein E (ApoE) variants have been linked to hypertriglyceridaemia and hypercholesterolaemia in normal individuals...
  14. ncbi Association of apolipoprotein E polymorphisms with normal tension glaucoma in a Chinese population
    Ching Yan Lam
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Kowloon, Hong Kong
    J Glaucoma 15:218-22. 2006
    To evaluate the role of apolipoprotein E (APOE) polymorphisms in primary open angle glaucoma (POAG).
  15. pmc Subsets of SNPs define rare genotype classes that predict ischemic heart disease
    Ruth Frikke-Schmidt
    Department of Clinical Biochemistry KB3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark
    Hum Genet 120:865-77. 2007
    ..In this study we determined the utility of exonic and 5' SNPs in apolipoprotein E (APOE) and lipoprotein lipase (LPL) when considered singly and in combination for predicting incidence of IHD ..
  16. ncbi Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency
    R M Miller
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA renee
    Neurobiol Aging 29:71-7. 2008
    ..addition to age, the most prevalent known risk factor for developing AD is carriage of the epsilon4 allele of Apolipoprotein E (ApoE)...
  17. ncbi The apolipoprotein E epsilon4-allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities
    P Høgh
    Memory Disorders Research Unit, The Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    Acta Neurol Scand 115:248-53. 2007
    b>Apolipoprotein E-epsilon4 (APOE-epsilon4) is a potential risk factor for cerebral vascular disease...
  18. ncbi [A study on the association of apolipoprotein E genotypes with primary open-angle glaucoma and primary angle-closure glaucoma in northeast of China]
    Hui ping Yuan
    Department of Ophthalmology, Second Affiliated Hospital of Harbin Medical University, Heilongjiang, Harbin 150086, China
    Zhonghua Yan Ke Za Zhi 43:416-20. 2007
    To analysis the association of apolipoprotein E (APOE) genotype with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) in northeast of China.
  19. ncbi Apolipoprotein E promoter polymorphisms (-491A/T and -427T/C) and Alzheimer's disease: no evidence of association in the Irish population
    C A Lynch
    Mercer s Institute for Research on Ageing, Hospital 4, St James s Hospital, Dublin 8, Ireland
    Ir J Med Sci 177:29-33. 2008
    ..Polymorphisms (-491A/T and -427T/C) at the promoter region of the APOE gene are postulated to affect the expression of the gene through differential binding of transcription factors...
  20. pmc Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China
    Gabriella Andreotti
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 17:525-34. 2008
    ..5-fold risk of bile duct cancer. Our findings suggest that gene variants in the lipid metabolism pathway contribute to the risk of biliary tract stones and cancers, particularly of the bile duct...
  21. doi Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model
    Partha S Bhattacharjee
    Departments of Ophthalmology, School of Public Health, LouisianaState University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Invest Ophthalmol Vis Sci 49:4263-8. 2008
    To evaluate efficacy of the small apolipoprotein E (apoE) mimetic dimer peptide (apoEdp) in the treatment of herpetic stromal keratitis in a mouse ocular model and determine its therapeutic effects against HSV-1-induced inflammatory ..
  22. pmc Apolipoprotein E epsilon4 allele and outcomes of traumatic spinal cord injury
    Amitabh Jha
    Craig Hospital Research Department, University of Colorado, 3425 S Clarkson Street, Englewood, CO 80113, USA
    J Spinal Cord Med 31:171-6. 2008
    To test the hypothesis that apolipoprotein E (APOE) polymorphisms are associated with outcomes after spinal cord injury (SCI).
  23. doi Glucose concentration in the dialysate does not contribute to lipid profiles in patients undergoing CAPD
    Zheng Li
    Department of Nephrology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, PR China
    Ren Fail 33:124-30. 2011
    ..We concluded that patients on CAPD exhibit dyslipidemia, and that different concentrations of glucose in the dialysate do not affect lipid profiles in these patients...
  24. ncbi [Comparative plasma proteomic analysis of patients with multiple myeloma treated with bortezomib-based regimens]
    J Cumova
    Babákova myelomová skupina, Ustav patologické fyziologie, LF MU Brno
    Klin Onkol 25:17-25. 2012
    ....
  25. pmc The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet
    Xin Xia Chang
    Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China
    Lipids Health Dis 11:86. 2012
    ..The study was undertaken to examine the effects of berberine (BBR) on serum homocysteine, lipids and the aortic lesion in Sprague-Dawley (SD) rats fed with a long-term high-fat diet (HFD)...
  26. ncbi Combined germline variations of thrombophilic genes promote genesis of lung cancer
    Filiz Ozen
    Department of Medical Genetics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey E mail
    Asian Pac J Cancer Prev 14:5449-54. 2013
    ..We aimed to investigate the prevalence of 5 thrombophilic germ-line mutations in patients with lung carcinomas...
  27. doi Neurobehavioral Deficits in a Rat Model of Recurrent Neonatal Seizures Are Prevented by a Ketogenic Diet and Correlate with Hippocampal Zinc/Lipid Transporter Signals
    Tian Tian
    Neurology Laboratory, Children s Hospital of Soochow University, No 303, Jingde Road, Suzhou, 215003, People s Republic of China
    Biol Trace Elem Res 167:251-8. 2015
    ..Our findings provide support for zinc/lipid transporter signals being potential targets for the treatment of neonatal seizure-induced brain damage by KD. ..
  28. doi ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion
    Z L Wang
    Department of Neurosurgery, the First Affiliated Hospital of Xinjiang Medical University, Urumuqi, Xinjiang Province, China
    Genet Mol Res 14:19275-81. 2015
    ..Our data demonstrate that the expression of ApoE and S-100 correlated with the progression of focal cerebral contusion. This suggests that both proteins may serve as effective biomarkers of focal cerebral contusions. ..
  29. ncbi Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males
    A Inbal
    Institute of Thrombosis and Hemostasis, Department of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Blood 93:2186-90. 1999
    ..7; 95% CI, 7.17 to 84.9). The presented data suggest a synergistic effect between atherogenic and thrombogenic risk factors in the pathogenesis of AMI, as was recently found in a similar cohort of women...
  30. ncbi The apolipoprotein E epsilon4 allele is unlikely to be a major risk factor of age-related macular degeneration in Chinese
    C P Pang
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong
    Ophthalmologica 214:289-91. 2000
    b>Apolipoprotein E (ApoE) is a major transporter of lipids and cholesterol in the nervous system...
  31. ncbi APOE and APOC1 genetic polymorphisms in age-associated memory impairment
    D Bartres-Faz
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain
    Neurogenetics 3:215-9. 2001
    ....
  32. ncbi Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus
    Matthew A Wozniak
    Molecular Neurobiology Laboratory, Department of Optometry and Neuroscience, University of Manchester Institute of Science and Technology, Manchester, UK
    Hepatology 36:456-63. 2002
    ..The virus associates with serum lipoproteins, including those containing apolipoprotein E (apoE) and apolipoprotein B (apoB), and may enter cells via the low-density lipoprotein receptor (LDLR)...
  33. ncbi A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy
    Silke Schmidt
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Ophthalmic Genet 23:209-23. 2002
    ..The epsilon4 allele of the apolipoprotein E gene (APOE-4) has previously been reported to have a protective effect on ARM risk, while the APOE-2 allele ..
  34. ncbi Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction
    Gysèle S Bleumink
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Am Heart J 147:685-9. 2004
    ..We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects...
  35. ncbi Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study
    Gerald Liew
    Centre for Vision Research, Univerisity of Sydney, Sydney, Australia
    Arch Ophthalmol 125:813-8. 2007
    To examine the association between apolipoprotein E (APOE) gene polymorphisms and retinal microvascular signs.
  36. ncbi A role for LRP4 in neuronal cell viability is related to apoE-binding
    Yonghao Lu
    Department of Neuroplasticity, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Brain Res 1177:19-28. 2007
    The distribution pattern of apolipoprotein E (apoE) in cortical neurons in culture resembles that of low-density lipoprotein receptor-related protein 4 (LRP4)...
  37. doi Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer
    Li Yan
    Division of Surgery and Oncology, Royal Liverpool University Hospital, Liverpool L68 3 GA, UK
    J Proteome Res 8:142-8. 2009
    ..or biliary duct obstruction, we observed that the plasma levels of apolipoprotein A1, transthyretin, and apolipoprotein E, when examined in isolation, were each associated with pancreatic cancer...
  38. doi Proteome analysis of rat serum proteins adsorbed onto synthetic octacalcium phosphate crystals
    Hirofumi Kaneko
    Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Anal Biochem 418:276-85. 2011
    ..analysis of the proteins detected was performed for the extracted two bone formation-related proteins apolipoprotein E (Apo E), a protein known to promote osteoblast differentiation, and complement 3 (C3). HA adsorbed C3 (3...
  39. doi Apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries
    Shujie Wei
    Department of Cardiology, Chengdu Military General Hospital, 270 Tianhui Rd, Rongdu Ave, Jinniu, Chengdu, Sichuan 610083, China
    Atherosclerosis 243:589-92. 2015
    The goal of this study was to establish an apolipoprotein E-deficient (ApoE(-/-)) rat model.
  40. ncbi SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Annu Rev Nutr 25:341-90. 2005
    ..In summary, there is need for both large population studies and well-standardized intervention studies...
  41. ncbi Involvement of apolipoprotein E in excess fat accumulation and insulin resistance
    Junhong Gao
    Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Diabetes 56:24-33. 2007
    Although apolipoprotein E (apoE) is well known to play a major role in lipid metabolism, its role in glucose and energy homeostasis remains unclear. Herein, we established apoE-deficient genetically obese Ay (apoE(-/-);Ay/+) mice...
  42. ncbi Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1
    Hideki Hayashi
    Group on Molecular and Cell Biology of Lipids and Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurosci 27:1933-41. 2007
    b>Apolipoprotein E (apoE)-containing lipoproteins (LPs) are secreted by glia and play important roles in lipid homeostasis in the CNS. Glia-derived LPs also promote synaptogenesis and stimulate axon growth of CNS neurons...
  43. pmc Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans
    Michael L James
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Stroke Cerebrovasc Dis 18:144-9. 2009
    ....
  44. pmc Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane
    Lili Yue
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Lipid Res 52:489-98. 2011
    ....
  45. doi Low cholesterol in dialysis patients--causal factor for mortality or an effect of confounding?
    Michal Chmielewski
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    Nephrol Dial Transplant 26:3325-31. 2011
    ..The aim of the study was to verify the hypothesis of time discrepancy of competing risks in 1191 incident dialysis patients (Netherlands Cooperative Study on the Adequacy of Dialysis)...
  46. pmc Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease
    Harini Bagavant
    Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Pathol 179:651-60. 2011
    ..b>Apolipoprotein E-deficient (ApoE(-/-)) mice develop hyperlipidemia and are a model for atherosclerosis...
  47. doi All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats
    Tian Biao Zhou
    Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
    Vascul Pharmacol 55:169-77. 2011
    b>Apolipoprotein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a key role in the pathogenesis of glomerulosclerosis (GS)...
  48. pmc Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis
    Jose A Diaz
    Department of Surgery, Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, Ann Arbor, MI 48109, USA
    J Vasc Surg 55:815-22. 2012
    ..We sought to determine the effects of PAI-1 in an in vivo hyperlipidemic model of VT...
  49. doi Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats
    Tian Biao Zhou
    Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
    Histol Histopathol 27:249-56. 2012
    ..We conducted this investigation to explore whether gelatinases were associated with the apoE accumulation in the pathological process of GS...
  50. pmc A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma
    Hideki Hayashi
    Priority Organization for Innovation and Excellence, Kumamoto University, Kumamoto 860 8556, Japan
    J Biol Chem 287:25395-406. 2012
    ..However, the clinical application of neuroprotection has not, so far, been successful. Here, we report that apolipoprotein E-containing lipoproteins (E-LPs) protect primary cultured RGCs from Ca(2+)-dependent, and mitochondrion-..
  51. doi A discovery-phase urine proteomics investigation in type 1 diabetes
    A Soggiu
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Milano, Milan, Italy
    Acta Diabetol 49:453-64. 2012
    ..in diabetic subjects were associated with Tamm-Horsfall urinary glycoprotein, apolipoprotein A-I, apolipoprotein E, α2-thiol proteinase inhibitor, and human complement regulatory protein CD59, while higher protein ..
  52. doi Proteinuria decreases tissue lipoprotein receptor levels resulting in altered lipoprotein structure and increasing lipid levels
    Limin Wang
    Department of Veteran s Affairs, Northern California Health Care System, Mather, California, USA
    Kidney Int 82:990-9. 2012
    ..b>Apolipoprotein E (apoE) was decreased in lipoprotein fractions in NS, but not in analbuminemia...
  53. ncbi Apolipoprotein E Sendai (arginine 145-->proline): a new variant associated with lipoprotein glomerulopathy
    S Oikawa
    First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Am Soc Nephrol 8:820-3. 1997
    ..It is believed that a genetic disorder of apo E may be present and associated with the disease. Three patients with LPG were examined in this study...
  54. ncbi Apolipoprotein E polymorphism influences lipid phenotypes in Chinese families with familial combined hyperlipidemia
    Wei Dong Pei
    Division of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Circ J 70:1606-10. 2006
    b>Apolipoprotein E (apoE) polymorphism is associated with changes in the lipoprotein profile of individuals with familial combined hyperlipidemia (FCHL), but its effects on the lipoprotein profiles of members of Chinese families with FCHL ..
  55. doi Liver X receptors regulate cholesterol homeostasis in oligodendrocytes
    Katherine Nelissen
    Biomedical Research Institute, Hasselt University, and transnational University Limburg, Diepenbeek, Belgium
    J Neurosci Res 90:60-71. 2012
    ..These data show that LXRs are involved in regulating cholesterol homeostasis in oligodendrocytes...
  56. doi Meta-analysis of genome-wide gene expression differences in onset and maintenance phases of genetic hypertension
    Francine Z Marques
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
    Hypertension 56:319-24. 2010
    ..Our meta-analysis has revealed many new genes for which the expression is altered in hypertension, so pointing to novel potential causative, maintenance, and responsive mechanisms and pathways...
  57. ncbi Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice
    Y Ishigaki
    Tohoku University Gene Research Center, Sendai 981 8555, Japan
    J Biol Chem 275:31269-73. 2000
    ..These LPG-like depositions were detected 6 days after virus injection and were sustained for at least 60 days. Our results demonstrated that apoE-Sendai is an etiological cause of LPG...
  58. ncbi The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndrome
    F Cardona
    Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, 29009 Malaga, Spain
    J Clin Endocrinol Metab 90:2972-5. 2005
    b>Apolipoprotein E (apo E) is a constituent molecule of the triglyceride-rich lipoproteins and participates in their clearance. Polymorphisms in the apo E gene are associated with increased fasting and postprandial levels of triglycerides...
  59. doi Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke
    Karsten Ruscher
    Department of Clinical Sciences, Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, University of Lund, Lund, Sweden
    J Cereb Blood Flow Metab 29:1796-805. 2009
    b>Apolipoprotein E (ApoE), a cholesterol transporter and an immunomodulator, is brain protective after experimental stroke and implicated in brain repair...
  60. pmc An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury
    Feng Qiao Li
    Cognosci, Inc, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 334:106-15. 2010
    Elevated apolipoprotein E (apoE) synthesis within crushed sciatic nerves advocates that apoE could benefit axonal repair and reconstruction of axonal and myelin membranes...
  61. pmc Genetic associations in diabetic nephropathy: a meta-analysis
    A L Mooyaart
    Department of Pathology, Bldg 1, L1 Q, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Diabetologia 54:544-53. 2011
    ..This meta-analysis assessed the pooled effect of each genetic variant reproducibly associated with diabetic nephropathy...
  62. pmc Early hypercholesterolemia contributes to vasomotor dysfunction and injury associated atherogenesis that can be inhibited by nitric oxide
    Kathleen G Raman
    Division of Vascular Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Vasc Surg 53:754-63. 2011
    ..The efficacy of NO therapy to protect against the injury response in this setting was also assessed...
  63. doi Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats
    Toshiaki Nakano
    Center for Translational Research in Biomedical Sciences, Liver Transplantation Program and Department of Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
    J Hepatol 55:415-25. 2011
    ..This study aimed to characterize lipid transfer/metabolic proteins as non-invasive diagnostic markers, and to evaluate the therapeutic effects of phototherapy on the progression of NASH in rats...
  64. doi Chronic renal failure alters endothelial function in cerebral circulation in mice
    Jean Marc Bugnicourt
    Institut National de Santé et de Recherche Médicale, ERI12, Amiens, France
    Am J Physiol Heart Circ Physiol 301:H1143-52. 2011
    ..in cerebral arterioles after 4 wk of chronic renal failure (CRF) in a well-defined murine model (C57BL/6J and apolipoprotein E knockout female mice)...
  65. pmc Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift
    Mary Jo Ladu
    Department of Anatomy and Cell Biology, University of Illinois, Chicago, IL 60612, USA
    Biochim Biophys Acta 1821:295-302. 2012
    The association between apolipoprotein E (apoE) and amyloid-β peptide (Aβ) may significantly impact the function of both proteins, thus affecting the etiology of Alzheimer's disease (AD)...
  66. pmc Biochemical and biophysical characterization of recombinant rat apolipoprotein E: similarities to human apolipoprotein E3
    Tuyen N Tran
    Department of Chemistry and Biochemistry, 1250 Bellflower Boulevard, California State University Long Beach, Long Beach, CA 90840, USA
    Arch Biochem Biophys 529:18-25. 2013
    b>Apolipoprotein E (apoE) is an anti-atherogenic protein that plays a critical role in maintaining plasma cholesterol and triglyceride homeostasis by virtue of its ability to act as a ligand for the low-density lipoprotein receptor (LDLr) ..
  67. ncbi Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis
    Sachiyo Yamaguchi
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 18:871-83. 2006
    ..Stratification of subjects on the basis of sex or conventional risk factors for atherosclerosis may therefore be important in order to achieve the personalized prevention of ACI with the use of genetic information...
  68. ncbi Is the ApoE polymorphism associated with dilated cardiomyopathy?
    D Jurkovicova
    Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Slovakia
    Gen Physiol Biophys 25:3-10. 2006
    b>Apolipoprotein E (ApoE) is 34 kDa protein involved in the modulation of cholesterol transport and homeostasis. Polymorphism of the ApoE gene has been implicated in many chronic cardiovascular and neuronal diseases...
  69. pmc Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex
    Stephen Arold
    School of Nursing and Mary S Easton Center for Alzheimer s Research, UCLA, Box 956919 Factor Bldg, Los Angeles, CA 90095 6919, USA
    Acta Neuropathol 123:39-52. 2012
    ..We have used flow cytometry analysis to measure apolipoprotein E (apoE) and amyloid beta peptide (Aβ) levels in large populations of synaptic terminals from AD and aged ..
  70. ncbi Severe type III hyperlipoproteinemia associated with unusual apolipoprotein E1 phenotype and epsilon 1/'null' genotype
    G Feussner
    Medizinische Universitatsklinik Heidelberg, Germany
    Eur J Clin Invest 22:599-608. 1992
    ..97 without therapy which is unusually high (normal ratio about 0.18). By contrast his plasma apo E level was only moderately elevated (6.8 mg dl-1)...
  71. ncbi Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I
    J K Boyles
    Gladstone Foundation Laboratories for Cardiovascular Disease, Department of Pathology, University of California, San Francisco 94140 0608
    J Biol Chem 265:17805-15. 1990
    ..The results from this study provide evidence that several different apolipoproteins from various sources may play a role in lipid transport within neural tissues...
  72. ncbi Effects of apolipoproteins A-IV and A-I on the uptake of phospholipid liposomes by hepatocytes
    C L Bisgaier
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032
    J Biol Chem 264:862-6. 1989
    ..As a positive control, apolipoprotein E doubled the uptake of labeled liposomes by hepatoma cells, compared to apolipoprotein-free controls, and this ..
  73. ncbi Structure and expression of the rat apolipoprotein E gene
    W P Fung
    J Biol Chem 261:13777-83. 1986
    The rat apolipoprotein E gene was isolated from a genomic library by screening with a cDNA probe. The nucleotide sequence of the gene plus a 5' flanking region of 623 nucleotides and a 3' flanking region of 234 nucleotides was determined...
  74. pmc Complete nucleotide sequence of the gene encoding the rat apolipoprotein E
    C Fukazawa
    Nucleic Acids Res 14:9527-8. 1986
  75. ncbi Rat apolipoprotein E mRNA. Cloning and sequencing of double-stranded cDNA
    J W McLean
    J Biol Chem 258:8993-9000. 1983
    A 900-base pair clone corresponding to rat liver apolipoprotein E (apo-E) mRNA, and containing a 3'-terminal poly(A) segment, was identified from a library of rat liver cDNA clones in the plasmid pBR322 by specific hybrid selection and ..
  76. ncbi Cell surface "blanket" of apolipoprotein E on rat adrenocortical cells
    D L Williams
    Department of Pharmacological Sciences, State University of New York at Stony Brook 11794, USA
    J Lipid Res 36:745-58. 1995
    ..These results are consistent with the idea that this cell surface "blanket" of apoE participates in the uptake of lipoprotein cholesterol by either the endocytic or selective uptake pathways...
  77. ncbi Secretion by Saccharomyces cerevisiae of rat apolipoprotein E as a fusion to Mucor rennin
    N Nomura
    Department of Biotechnology, University of Tokyo, Japan
    Appl Microbiol Biotechnol 42:865-70. 1995
    As the first step for production of rat apolipoprotein E (rApoE) in Saccharomyces cerevisiae, the rApoE cDNA was cloned and its nucleotide sequence was determined...
  78. pmc Concentration of intracellular hepatic apolipoprotein E in Golgi apparatus saccular distensions and endosomes
    S Dahan
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    J Cell Biol 127:1859-69. 1994
    The intrahepatic distribution of apolipoprotein E has been assessed by immunogold labeling of cryosections as well as by Western blotting of organelles isolated from liver homogenates...
  79. ncbi Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat
    K Horsburgh
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, UK
    Neuropathol Appl Neurobiol 22:342-9. 1996
    The aim of this study was to examine the cellular localization and alterations of apolipoprotein E (apoE) following a transient ischaemic insult using immunohistochemistry...
  80. ncbi Apolipoprotein E genotype is associated with differential expansion rates of small abdominal aortic aneurysms
    L U Gerdes
    Department of Clinical Biochemistry, Aarhus University Hospital, Denmark
    Br J Surg 87:760-5. 2000
    The common polymorphism of the apolipoprotein E (APOE) gene is associated with differential risk of atherosclerosis; the gene could be a candidate gene in abdominal aortic aneurysms (AAA).
  81. ncbi Chronic ethanol exposure in rats affects rabs-dependent hepatic trafficking of apolipoprotein E and transferrin
    P Marmillot
    Lipid Research Laboratory, DVA Medical Center, Washington, DC 20422, USA
    Alcohol 25:195-200. 2001
    ..protein trafficking, we tested whether chronic ethanol exposure affected the trafficking of newly synthesized apolipoprotein E (apoE) or transferrin (O-glycosylated and N-glycosylated proteins, respectively) attached to acylated or ..
  82. ncbi Apolipoprotein E gene promoter (-219G/T) polymorphism is associated with premature coronary heart disease
    L Viitanen
    Department of Medicine, University of Kuopio, 70210 Kuopio, Finland
    J Mol Med (Berl) 79:732-7. 2001
    ..Additionally, when the two apo E gene polymorphisms were combined, affected siblings and probands had a higher frequency of the -219T allele and ..
  83. ncbi Apolipoprotein E and lipoprotein lipase increase triglyceride-rich particle binding but decrease particle penetration in arterial wall
    Adam E Mullick
    Division of Endocrinology, University of California, Davis 95616, USA
    Arterioscler Thromb Vasc Biol 22:2080-5. 2002
    Liver-derived apolipoprotein E (apoE) decreases atherosclerosis without altering the circulating concentrations of plasma lipoproteins...
  84. ncbi APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study
    Qi Chen
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 130 De Soto Street, Pittsburgh, PA 15261, USA
    Atherosclerosis 169:159-67. 2003
    Genetic variation in the apolipoprotein E (APOE) gene is a significant determinant of variation in plasma cholesterol levels and it also affects the risk of coronary artery disease (CAD)...
  85. ncbi Neuronal apolipoprotein E is not synthesized in neuron after focal ischemia in rat brain
    Masami Nishio
    Department of Neurosurgery, Osaka University Medical School, 2 2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurol Res 25:390-4. 2003
    b>Apolipoprotein E (ApoE) is a major apolipoprotein in the central nervous system (CNS) that plays an important role in Alzheimer's disease. It may also be involved in other CNS disorders including ischemic injury...
  86. ncbi Spatiotemporal changes of apolipoprotein E immunoreactivity and apolipoprotein E mRNA expression after transient middle cerebral artery occlusion in rat brain
    Hiroshi Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Neurosci Res 73:545-56. 2003
    b>Apolipoprotein E (ApoE) is a constituent of lipoprotein and plays an important role in the maintenance of neural networks...
  87. ncbi Postprandial triglyceride levels in familial combined hyperlipidemia. The role of apolipoprotein E and lipoprotein lipase polymorphisms
    István Reiber
    Department of Internal Medicine, Szent György Hospital Székesfehérvár, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary
    J Nutr Biochem 14:394-400. 2003
    The effect of apolipoprotein E genotype and polymorphisms of lipoprotein lipase gene on plasma postprandial triglyceride levels in familial combined hyperlipidemic subjects and their relatives have not been sufficiently studied...
  88. ncbi Bacterial expression and characterization of rat apolipoprotein E
    Kevin Pearson
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267, USA
    Protein Expr Purif 41:447-53. 2005
    ..The recombinant protein was then compared both structurally and functionally to rat plasma apoE. This expression system will be highly useful for probing the ability of rat apoE to mediate food intake in rats...
  89. ncbi Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes
    Alfred Rapp
    Department of Medical Chemistry, MedUniWien, Center of Physiology and Pathophysiology, Medical University of Vienna, Währingerstrasse 10, 1090 Vienna, Austria
    Biochimie 88:473-83. 2006
    b>Apolipoprotein E (apoE) has been genetically linked to late-onset Alzheimer's disease...
  90. pmc Alveolar type I cells protect rat lung epithelium from oxidative injury
    Jiwang Chen
    Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    J Physiol 572:625-38. 2006
    ..Nine out of 10 selected genes were verified by quantitative real-time PCR. Two genes, apolipoprotein E (Apo E) and transferrin, were further characterized and functionally studied...
  91. ncbi 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux
    Karlygash Abildayeva
    Department of Molecular Cell Biology, Institute of Brain and Behavior European Graduate School of Neuroscience, EURON, University of Maastricht, 6200 MD Maastricht, The Netherlands
    J Biol Chem 281:12799-808. 2006
    Both apolipoprotein E (apoE) and 24(S)-hydroxycholesterol are involved in the pathogenesis of Alzheimer disease (AD)...
  92. ncbi Effect of fungal polysaccharides on the modulation of plasma proteins in streptozotocin-induced diabetic rats
    Sang Woo Kim
    Department of Biotechnology, Daegu University, Kyungsan, Kyungbuk, Korea
    Proteomics 6:5291-302. 2006
    ..effect of diabetes induction on the pattern of rat plasma proteins includes the down-regulation of albumin, apolipoprotein E (Apo E), alpha1-inhibitor-3, fetuin beta, Gc-globulin, hemopexin, vitronectin, and transthyretin (TTR) ..
  93. ncbi Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice
    Celina V Zerbinatti
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:36180-6. 2006
    ..Interestingly, PDAPP mice lacking apolipoprotein E (apoE) had much less intraneuronal Abeta42...
  94. ncbi C-terminal apolipoprotein E-derived peptide, Ep1.B, displays anti-atherogenic activity
    Leila Bocksch
    Vascular Biology Group, Robarts Research Institute, Canada
    Atherosclerosis 194:116-24. 2007
    b>Apolipoprotein E (ApoE) is a lipid transport protein with expanded functions in cellular responses to tissue injury, immune regulation and cell growth...
  95. ncbi Pro-inflammatory cytokines modulate glial apolipoprotein E secretion
    Rosanne Aleong
    Department of Neurology and Neurosurgery, Montreal, Quebec, Canada
    Curr Alzheimer Res 5:33-7. 2008
    ..Studies have also established the apolipoprotein E (apoE) gene to be a risk factor for AD with epsilon4 carriers having been found to show lower levels of brain ..
  96. ncbi The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation
    Tomohiro Aoki
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Int J Mol Med 21:453-9. 2008
    ..The relation of hypercholesterolemia and apolipoprotein E (ApoE) to cerebral aneurysm formation, has been unclear until now...
  97. pmc Brain apolipoprotein E: an important regulator of food intake in rats
    Ling Shen
    Cincinnati Obesity Research Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Diabetes 57:2092-8. 2008
    ....
  98. pmc Food-entrained rhythmic expression of apolipoprotein E expression in the hypothalamus of rats
    Ling Shen
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0529, USA
    Brain Res 1273:66-71. 2009
    b>Apolipoprotein E (apoE) is a protein mainly synthesized in the liver and brain...
  99. doi Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E
    Barbara Lorber
    Molecular Neuroscience Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    J Neurosci Res 87:2645-52. 2009
    ..Glial-related neurite outgrowth appears to be, at least in part, mediated via apolipoprotein E (ApoE), which is expressed by activated retinal astrocytes and Müller glia...

Research Grants10

  1. Inducible NOS as a Treatment Target in CLL
    J Weinberg; Fiscal Year: 2005
    ....
  2. Acupuncture for treatment of acute spinal cord injury
    Amitabh Jha; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Amyloid beta conformation-specific monoclonal antibodies
    Mary Jo Ladu; Fiscal Year: 2005
    ..5. An ELISA capture assay will be designed, using existing and novel antibodies, to facilitate measurement of soluble A¿ oligomers in extracts of brain, CSF, and sera. ..
  4. APOE AND BETA AMYLOID INTERACTIONS--EFFECTS ON NEUROTOX
    Mary Jo Ladu; Fiscal Year: 2004
    ....
  5. Brain Apolipoprotein AIV, Food Intake and Obesity
    Min Liu; Fiscal Year: 2007
    ..This new knowledge may lead to novel targets for preventive and therapeutic interventions that will be particularly important to the growing numbers of obese persons in this country. ..
  6. Novel Restorative Therapy For Spinal Cord Injury
    Feng Qiao Li; Fiscal Year: 2006
    ..developed an anti-inflammatory/neuroprotective peptide, COG133 derived from the receptor-binding region of apolipoprotein E (apoE)...
  7. Development of Remyelinating Agents
    Feng Qiao Li; Fiscal Year: 2007
    ..Our interest in developing apolipoprotein E-based remyelinating agents is derived from our unique understanding that 1) apoE is the principal ..
  8. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2010
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
  9. Regulatory T cells in Systemic Lupus Erythematosus
    Harini Bagavant; Fiscal Year: 2007
    ..This award will help to overcome the lag period in my career induced by my leave of absence and return to a new field of study, and will facilitate my aim of becoming an independent scientist. ..
  10. Novel Therapy for Multiple Sclerosis (SBIR-Phase II)
    Feng Qiao Li; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..