Apoh

Summary

Gene Symbol: Apoh
Description: apolipoprotein H
Alias: beta-2-glycoprotein 1, B2GPI, apo-H, beta(2)GPI, beta-2-glycoprotein I
Species: rat

Top Publications

  1. doi A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome
    Chiara Agostinis
    Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico Burlo Garofolo, Trieste, Italy
    Blood 123:3478-87. 2014
  2. doi Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds
    Shingo Okubo
    Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
    Toxicol Sci 132:21-31. 2013
  3. pmc Dietary oil modifies the plasma proteome during aging in the rat
    Monica Santos-Gonzalez
    Departamento de Biologia Celular, Fisiologia e Inmunologia, University of Cordoba, Spain
    Age (Dordr) 34:341-58. 2012
  4. ncbi Anti-beta 2-glycoprotein I antibodies bind to central nervous system
    B Caronti
    Dipartimento di Science Neurologiche, Universita La Sapienza, Rome, Italy
    J Neurol Sci 156:211-9. 1998
  5. ncbi beta 2-glycoprotein I (apolipoprotein H) modulates uptake and endocytosis associated chemiluminescence in rat Kupffer cells
    L F Gomes
    Disciplina de Patologia, Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av Lineu Prestes n 580, Bloco 17 superior CEP 05508 900, Sao Paulo, Brazil
    Free Radic Res 36:741-7. 2002
  6. ncbi Relation of preexisting anti-beta2GPI antibodies to infarct size in a rat model
    I Barshack
    Department of Pathology, Sheba Medical Center, Tel Hashomer 52621, Israel
    Cardiovasc Pathol 12:195-201. 2003
  7. ncbi Proteomic analysis of vitreous from diabetic macular edema
    Masayuki Ouchi
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kamigyo ku, Kyoto 602 0841, Kyoto, Japan
    Exp Eye Res 81:176-82. 2005
  8. ncbi Beta-2-glycoprotein I is growth regulated and plays a role as survival factor for hepatocytes
    Maurizio Averna
    Department of Internal Medicine, University of Palermo, Via del Vespro 141, 90127 Palermo, Italy
    Int J Biochem Cell Biol 36:1297-305. 2004
  9. doi Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies
    Libor Hradecky
    Department of Gynecology and Obstetrics, Charles University and Faculty Hospital, Pilsen, Czech Republic
    Am J Reprod Immunol 62:412-7. 2009
  10. doi Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients
    Rafael Simo
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Arch Ophthalmol 126:1076-81. 2008

Scientific Experts

  • I Barshack
  • Henrique Luiz Staub
  • L R Lopez
  • Rafael Simo
  • L F Gomes
  • Marcus Franck
  • Chiara Agostinis
  • Shingo Okubo
  • Monica Santos-Gonzalez
  • Francesco Tedesco
  • Daniele Sblattero
  • Paolo Macor
  • Paolo Durigutto
  • Roberta Bulla
  • Libor Hradecky
  • Fabio Fischetti
  • Masayuki Ouchi
  • Maurizio Averna
  • Aline Ranzolin
  • Spiros Miyakis
  • X Yan
  • Filomena Guida
  • Maria O Borghi
  • Pier Luigi Meroni
  • Claudia Grossi
  • Francesca Pregnolato
  • Makoto Miyamoto
  • Hiroshi Yamada
  • Atsushi Ono
  • Noriyuki Nakatsu
  • Kenji Takami
  • Masayuki Kanki
  • Yasuo Ohno
  • Tetsuro Urushidani
  • Francisco Perez-Jimenez
  • Jose Lopez-Miranda
  • Jose M Villalba
  • Placido Navas
  • Z Ulcova-Gallova
  • P Cavallo Perin
  • Ivan Subrt
  • Zdenka Ulcova-Gallova
  • R Gambino
  • M Cassader
  • G Pagano
  • B Caronti
  • K Anzai
  • Shigeru Kinoshita
  • Federica Ziller
  • Karen West
  • Fleur Bossi
  • Valentina Pellis
  • Alessandra Debeus
  • John W Crabb
  • Pierluigi Meroni
  • Motohiro Kamei
  • Giovanni Bartoloni
  • Gaetano Magro
  • Steven A Krilis
  • Salvatore Travali
  • J A A M Kamps
  • Gary L Norman
  • Bill Giannakopoulos
  • Maria Ragusa
  • Euler Manenti
  • Giuseppina Marino
  • G Ruiu
  • K Poelstra
  • Daniela Callari
  • Davide Noto
  • Jussara Marilú Bohn
  • H W M Morselt
  • G L Scherphof
  • Carlos Alberto von Muhlen
  • Alberto Notarbartolo
  • Maria Clorinda Mazzarino
  • Angelo Baldassare Cefalù
  • Giovanni Emmanuele
  • Carlo Maria Barbagallo
  • Luis Carlos Bodanese
  • Gianluca Paravizzini
  • K Krizanovská
  • Z Rokyta
  • V Bouse
  • L Netrvalová
  • M Balvin
  • S Giunti
  • G Gruden
  • L Arnaldi
  • Y Niho

Detail Information

Publications25

  1. doi A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome
    Chiara Agostinis
    Institute for Maternal and Child Health, Istituto di Ricovero e Cura a Carattere Scientifico Burlo Garofolo, Trieste, Italy
    Blood 123:3478-87. 2014
    ..The CH2-deleted antibody represents an innovative approach potentially useful to treat APS patients refractory to standard therapy. ..
  2. doi Identification of novel liver-specific mRNAs in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds
    Shingo Okubo
    Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
    Toxicol Sci 132:21-31. 2013
    ..Among six genes selected from the database, high liver specificity of apolipoprotein h (Apoh) and group-specific component (Gc) mRNAs were confirmed by reverse transcription (RT)-PCR and the copy numbers of ..
  3. pmc Dietary oil modifies the plasma proteome during aging in the rat
    Monica Santos-Gonzalez
    Departamento de Biologia Celular, Fisiologia e Inmunologia, University of Cordoba, Spain
    Age (Dordr) 34:341-58. 2012
    ..Our unbiased analysis reinforces the beneficial role of a diet rich in virgin olive oil compared with a diet rich in sunflower oil, modulating inflammation, homeostasis, oxidative stress, and cardiovascular risk during aging...
  4. ncbi Anti-beta 2-glycoprotein I antibodies bind to central nervous system
    B Caronti
    Dipartimento di Science Neurologiche, Universita La Sapienza, Rome, Italy
    J Neurol Sci 156:211-9. 1998
    ..Because of the presence of aCL in all patient sera, and the CNS involvement in three control patients, it is not possible to attribute a direct role for a beta 2-GPI in neurological diseases in this study...
  5. ncbi beta 2-glycoprotein I (apolipoprotein H) modulates uptake and endocytosis associated chemiluminescence in rat Kupffer cells
    L F Gomes
    Disciplina de Patologia, Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Av Lineu Prestes n 580, Bloco 17 superior CEP 05508 900, Sao Paulo, Brazil
    Free Radic Res 36:741-7. 2002
    beta 2-Glycoprotein I (beta 2 GPI) is known to influence macrophage uptake of particles with phosphatidylserine containing surfaces, as apoptotic thymocytes and unilamellar vesicles in vitro...
  6. ncbi Relation of preexisting anti-beta2GPI antibodies to infarct size in a rat model
    I Barshack
    Department of Pathology, Sheba Medical Center, Tel Hashomer 52621, Israel
    Cardiovasc Pathol 12:195-201. 2003
    ..Herein, we evaluated the role of preexisting high levels of aPL antibodies in determining the size of the infarct induced by permanent ligation of the left anterior descending artery (LAD) in a rat model...
  7. ncbi Proteomic analysis of vitreous from diabetic macular edema
    Masayuki Ouchi
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji Kamigyo ku, Kyoto 602 0841, Kyoto, Japan
    Exp Eye Res 81:176-82. 2005
    ..On the other hand, Apo H was expressed only in non-DME. Certain vitreous proteins expressed exclusively in DME and lacked in DME...
  8. ncbi Beta-2-glycoprotein I is growth regulated and plays a role as survival factor for hepatocytes
    Maurizio Averna
    Department of Internal Medicine, University of Palermo, Via del Vespro 141, 90127 Palermo, Italy
    Int J Biochem Cell Biol 36:1297-305. 2004
    ....
  9. doi Urgent termination of pregnancy in pre-eclampsia and panel of antiphospholipid antibodies
    Libor Hradecky
    Department of Gynecology and Obstetrics, Charles University and Faculty Hospital, Pilsen, Czech Republic
    Am J Reprod Immunol 62:412-7. 2009
    ....
  10. doi Elevation of apolipoprotein A-I and apolipoprotein H levels in the vitreous fluid and overexpression in the retina of diabetic patients
    Rafael Simo
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Arch Ophthalmol 126:1076-81. 2008
    To determine levels of apolipoprotein (apo) A-I and apo H in the vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and to examine whether apo A-I and apo H messenger RNA (mRNA) levels are overexpressed in the ..
  11. ncbi Autoantibodies to the atheroma component beta2-glycoprotein I and risk of symptomatic peripheral artery disease
    Marcus Franck
    Department of Rheumatology, Universidade Catolica do Rio Grande do Sul, Porto Alegre, Brazil
    Angiology 58:295-302. 2007
    ..The occurrence of these autoantibodies might represent one of the links between autoimmunity and atherosclerosis in patients with sPAD...
  12. ncbi Oxidized low-density lipoprotein/beta2-glycoprotein I complexes and autoantibodies in patients with type 2 diabetes mellitus
    Luis R Lopez
    Corgenix Inc, 12061 Tejon Street, Westminster, CO 80234, USA
    Ann N Y Acad Sci 1051:97-103. 2005
    ..The interaction of oxLDL with beta(2)-GPI in circulation suggests the intriguing possibility that oxLDL/beta(2)-GPI complexes may also play a role in the development of atherosclerosis and/or cardiovascular complications in DM...
  13. ncbi Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor
    Fabio Fischetti
    Department of Physiology and Pathology, University of Trieste, Trieste, Italy
    Blood 106:2340-6. 2005
    ..In conclusion, our data indicate that antibodies to beta2-glycoprotein I trigger coagulation subsequent to a priming proinflammatory factor and that the terminal C complex is the main mediator of the coagulation process...
  14. ncbi The role of beta2-glycoprotein I in liposome-hepatocyte interaction
    X Yan
    Groningen University Institute for Drug Exploration, Department of Cell Biology, University of Groningen, The Netherlands
    Biochim Biophys Acta 1667:208-14. 2004
    ..On the contrary, an inhibitory effect was observed. We conclude that despite abundant adsorption to negatively charged liposomes, beta2GP1 inhibits, rather than enhances, liposome uptake by liver cells...
  15. ncbi Beta 2 glycoprotein I--function in health and disease
    Spiros Miyakis
    Department of Immunology, Allergy and Infectious Diseases, University of New South Wales, St George Hospital, 2 South Street, Kogarah, NSW 2217, Australia
    Thromb Res 114:335-46. 2004
    ..Moreover, because beta2GPI is the dominant autoantigen in patients with APS, dysregulation of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS...
  16. ncbi Anti-beta2-glycoprotein I antibodies as risk factors for acute myocardial infarction
    Aline Ranzolin
    Hospital Sao Lucas, PUCRS, Porto Alegre, RS, Brazil
    Arq Bras Cardiol 83:141-4; 137-40. 2004
    ..To determine whether high levels of antibodies against the phospholipid beta2-glycoprotein I (beta2-gpI) cofactor are associated with an increase in the risk of acute myocardial infarction...
  17. pmc The primary structure of rat beta 2-glycoprotein I
    Y Aoyama
    Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637
    Nucleic Acids Res 17:6401. 1989
  18. ncbi Antibodies to the atherosclerotic plaque components beta2-glycoprotein I and heat-shock proteins as risk factors for acute cerebral ischemia
    Henrique Luiz Staub
    Laborat rio de Imunorreumatologia, Pontif cia Universidade Cat lica do Rio Grande do Sul, Porto Alegre, RS, Brasil
    Arq Neuropsiquiatr 61:757-63. 2003
    ..The association occurred independently of other risk factors. This humoral response might link autoimmunity, thrombophilia and atherosclerosis in stroke patients...
  19. ncbi Beta 2-glycoprotein I is a good indicator of certain adverse pregnancy conditions
    Z Ulcova-Gallova
    Department of Obstetrics and Gynecology, Charles University, Pilsen, Czech Republic
    Int J Fertil Womens Med 46:304-8. 2001
    ..To compare levels of beta2-glycoprotein I antibodies with six different antiphospholipid antibodies (aPL) in sera from patients with certain adverse pregnancy conditions...
  20. ncbi Apolipoprotein H is increased in type 2 diabetic patients with microalbuminuria
    P Cavallo Perin
    Department of Internal Medicine, University of Turin, Turin, Italy
    Nutr Metab Cardiovasc Dis 10:311-4. 2000
    Serum apolipoprotein H (Apo H) levels are increased in hyperlipidemic subjects and type 2 diabetics, but unknown in microalbuminuria, another disorder with an increased cardiovascular risk...
  21. pmc Beta2-glycoprotein I-dependent and -independent anticardiolipin antibody in non-obese diabetic (NOD) mice
    K Anzai
    Department of Laboratory Medicine, Fukuoka University School of Medicine, Japan
    Clin Exp Immunol 111:173-80. 1998
    ..In conclusion, aCL with multiple antigenic specificity were produced in NOD mice along with the development of insulitis and diabetes. NOD mice should thus be added to the list of animal models possessing antiphospholipid antibody...
  22. ncbi Influence of APOH protein polymorphism on apoH levels in normal and diabetic subjects
    G Ruiu
    Department of Internal Medicine, University of Turin, Italy
    Clin Genet 52:167-72. 1997
    ..b>APOH displays a genetically determined structural polymorphism: three alleles (APOH*1, APOH*2, APOH*3) at a single locus ..
  23. ncbi Studies on the possible function of beta 2-glycoprotein-I: influence in the triglyceride metabolism in the rat
    H Wurm
    Metabolism 31:484-6. 1982
    ..It is concluded that beta 2-glycoprotein-I affects the triglyceride clearance under these experimental conditions...