Apln

Summary

Gene Symbol: Apln
Description: apelin
Alias: Apel, apelin, APJ endogenous ligand, apelin, AGTRL1 ligand
Species: rat

Top Publications

  1. ncbi Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum
    Y Habata
    Discovery Research Laboratories 1, Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki, Japan
    Biochim Biophys Acta 1452:25-35. 1999
  2. ncbi Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury
    Lauren A O'Donnell
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 102:1905-17. 2007
  3. doi A possible role for hypoxia-induced apelin expression in enteric cell proliferation
    Song Han
    Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1832-9. 2008
  4. doi Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension
    Carolina Tiani
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, CIBERehd, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 50:296-305. 2009
  5. pmc Apelin gene transfer into the rostral ventrolateral medulla induces chronic blood pressure elevation in normotensive rats
    Qi Zhang
    Department of Pharmaceutical Sciences, North Dakota State University, 1401 Albrecht Blvd, Fargo, ND 58105, USA
    Circ Res 104:1421-8. 2009
  6. ncbi Hypoxia inducible factor regulates the cardiac expression and secretion of apelin
    Veli Pekka Ronkainen
    Department of Physiology, University of Oulu and Biocenter Oulu, Finland
    FASEB J 21:1821-30. 2007
  7. ncbi Interactions between apelin and angiotensin II on rat portal vein
    Bogdan Gurzu
    Faculty of Medicine, Department of Physiology, University of Medicine and Pharmacy Gr T Popa, 16 Universitatii Str, RO 700115 Iasi, Romania
    J Renin Angiotensin Aldosterone Syst 7:212-6. 2006
  8. ncbi Apelin protects against cardiomyocyte apoptosis induced by glucose deprivation
    Zhi Zhang
    Department of Cardiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
    Chin Med J (Engl) 122:2360-5. 2009
  9. ncbi Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-angiotensin type 1 receptor system
    Yoshitaka Iwanaga
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoinn kawahara cho Sakyo ku, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 41:798-806. 2006
  10. ncbi Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats
    Jing Zhang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Life Sci 79:1153-9. 2006

Scientific Experts

  • Hamid Najafipour
  • R Zabielski
  • Mehmet Bulbul
  • Jens Peter Goetze
  • Inho Soh
  • Jiu Chang Zhong
  • Yoshitaka Iwanaga
  • Bogdan Gurzu
  • Tim Van Mieghem
  • Zhen Gui Huang
  • David Sunter
  • Guiyun Wang
  • Song Han
  • Catherine Llorens-Cortes
  • Ella W Englander
  • George H Greeley
  • Qi Feng Liu
  • Xiang Qi
  • Ines Falcao-Pires
  • Annabelle Reaux-Le Goazigo
  • Sylvain Mayeur
  • Gui zhou Tao
  • Zhi Zhang
  • Laurence Bodineau
  • Dennis K Lee
  • Xuemin Zhang
  • Agnieszka Cudnoch-Jedrzejewska
  • Aung Than
  • Feng Xie
  • Hong wei Yu
  • Laura Butruille
  • Jing Zhang
  • Jean Lesage
  • Lu You
  • Alejandro D Hofmann
  • Didier Vieau
  • Claude Knauf
  • Hongxian Wu
  • Emilie Ceraudo
  • Raziye Akcılar
  • Amit Modgil
  • Chen Wang
  • N Dib
  • Joanna Ivars
  • Shino Ohno
  • Xin lei Wang
  • Si Chen
  • Yan Bo
  • Chengwen Sun
  • Xiaogang Zhang
  • STEPHEN T O'ROURKE
  • Rodrigo Alvear-Perez
  • Nádia Gonçalves
  • Y Kawamata
  • Alain Frugière
  • Federico Soriguer
  • Qi Zhang
  • Carolina Tiani
  • Y Habata
  • Annette Hus-Citharel
  • Alessandro Principe
  • Zhao Li
  • G Erdem
  • Françoise Moos
  • Klára Farkasfalvi
  • Veli Pekka Ronkainen
  • Lauren A O'Donnell
  • Diego García-Díaz
  • Pavan Atluri
  • Tatsuo Hashimoto
  • Yue Xia Jia
  • Patrick T Ellinor
  • Tieying Dai
  • Anaya Mitra
  • Yong Fen Qi
  • Shuntaro Kagiyama
  • Wei Wei
  • M V Heinonen
  • Regina Cheng
  • Susan R George
  • Tuan Nguyen
  • Brian F O'Dowd
  • R Fujii
  • C Kitada
  • M Hosoya
  • S Fukusumi
  • Nadia De Mota
  • H Onda
  • M Jászberényi
  • S Hinuma

Detail Information

Publications72

  1. ncbi Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum
    Y Habata
    Discovery Research Laboratories 1, Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, Ibaraki, Japan
    Biochim Biophys Acta 1452:25-35. 1999
    ..Hinuma et al., Nature 393 (1998) 272-276], we have recently identified a natural ligand, apelin, for the orphan 7TMR, APJ [K. Tatemoto et al., Biochem. Biophys. Res. Commun. 251 (1998) 471-476]...
  2. ncbi Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury
    Lauren A O'Donnell
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurochem 102:1905-17. 2007
    ..We now demonstrate that the endogenous APJ peptide ligand apelin activates signaling pathways in rat hippocampal neurons and modulates neuronal survival...
  3. doi A possible role for hypoxia-induced apelin expression in enteric cell proliferation
    Song Han
    Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1832-9. 2008
    b>Apelin is the endogenous ligand for the APJ receptor, and apelin and APJ are expressed in the gastrointestinal (GI) tract. Intestinal inflammation increases intestinal hypoxia-inducible factor (HIF) and apelin expression...
  4. doi Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension
    Carolina Tiani
    Hepatic Hemodynamic Laboratory, Liver Unit, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, CIBERehd, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    J Hepatol 50:296-305. 2009
    ..The apelin/APJ signaling pathway plays a crucial role in angiogenesis...
  5. pmc Apelin gene transfer into the rostral ventrolateral medulla induces chronic blood pressure elevation in normotensive rats
    Qi Zhang
    Department of Pharmaceutical Sciences, North Dakota State University, 1401 Albrecht Blvd, Fargo, ND 58105, USA
    Circ Res 104:1421-8. 2009
    The peripheral apelin system plays a significant role in cardiovascular homeostasis and in the pathophysiology of cardiovascular diseases...
  6. ncbi Hypoxia inducible factor regulates the cardiac expression and secretion of apelin
    Veli Pekka Ronkainen
    Department of Physiology, University of Oulu and Biocenter Oulu, Finland
    FASEB J 21:1821-30. 2007
    b>Apelin and its G-protein-coupled receptor APJ have various beneficial effects on cardiac function and blood pressure. The mechanisms that regulate apelin gene expression are not known...
  7. ncbi Interactions between apelin and angiotensin II on rat portal vein
    Bogdan Gurzu
    Faculty of Medicine, Department of Physiology, University of Medicine and Pharmacy Gr T Popa, 16 Universitatii Str, RO 700115 Iasi, Romania
    J Renin Angiotensin Aldosterone Syst 7:212-6. 2006
    b>Apelin (AP), an endogenous ligand of the APJ receptor, is involved in the regulation of cardiovascular homeostasis. Regardless the multiple similarities between AP and angiotensin II (Ang II), their roles seem to be different...
  8. ncbi Apelin protects against cardiomyocyte apoptosis induced by glucose deprivation
    Zhi Zhang
    Department of Cardiology, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China
    Chin Med J (Engl) 122:2360-5. 2009
    Apoptosis is a major cause of ischemic heart dysfunction. Apelin, the endogenous ligand for the G-protein-coupled APJ receptor, has been reported to exert cardioprotective effects during myocardial injury...
  9. ncbi Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-angiotensin type 1 receptor system
    Yoshitaka Iwanaga
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, 54 Shogoinn kawahara cho Sakyo ku, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 41:798-806. 2006
    Cardiac apelin has recently been suggested to contribute to the pathophysiology of heart failure (HF) in humans. In animal experiments, its infusion acutely improved systolic as well as diastolic LV function...
  10. ncbi Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats
    Jing Zhang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Life Sci 79:1153-9. 2006
    Because apelin may play an important regulatory role in human cardiac dysfunction, we investigated alterations in cardiovascular content of apelin and its receptor, APJ, during hypertension and the effect of exercise training on the ..
  11. ncbi Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding
    M V Heinonen
    Department of Biotechnology Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, 70211 Kuopio, Finland
    Regul Pept 130:7-13. 2005
    ..In the present study we investigated basal plasma levels of apelin, orexin-A, and leptin in morbid obese patients...
  12. ncbi Effects of all-trans retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats
    Jiu Chang Zhong
    Center for Molecular Biology, Shantou University Medical College, Shantou, Guangdong 515041, China
    Cardiovasc Res 65:743-50. 2005
    ..To further validate effects of atRA on the cardiovascular GPCRs, the present study was designed to assess whether atRA will modulate orphan receptor APJ, a homologue of angiotensin II type 1 (AT(1)) receptor...
  13. ncbi Characterization of apelin, the ligand for the APJ receptor
    D K Lee
    Department of Pharmacology, University of Toronto, Ontario, Canada
    J Neurochem 74:34-41. 2000
    The apelin peptide was recently discovered and demonstrated to be the endogenous ligand for the G protein-coupled receptor, APJ...
  14. ncbi Molecular properties of apelin: tissue distribution and receptor binding
    Y Kawamata
    Discovery Research Laboratories 1, Pharmaceutical Discovery Research Division, Takeda Chemical Industries, Ltd, Wadai 10, Tsukuba, 300 4293, Ibaraki, Japan
    Biochim Biophys Acta 1538:162-71. 2001
    We analyzed the tissue distribution of apelin mRNA in rats by a quantitative reverse transcription-polymerase chain reaction and that of immunoreactive apelin (ir-apelin) by an enzyme immunoassay (EIA) using a monoclonal antibody...
  15. ncbi Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain
    A Reaux
    Institut National de la Sante et de la Recherche Medicale, Paris, France Laboratory of Neuromorphology, Faculty of Medicine Semmelweis University, Budapest, Hungary
    J Neurochem 77:1085-96. 2001
    b>Apelin, a peptide recently isolated from bovine stomach tissue extracts, has been identified as the endogenous ligand of the human orphan APJ receptor...
  16. ncbi Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor
    K Tatemoto
    Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371 8512, Japan
    Biochem Biophys Res Commun 251:471-6. 1998
    ..By monitoring this activity, we isolated an APJ receptor ligand, designated apelin, from bovine stomach extracts...
  17. ncbi Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion
    Guiyun Wang
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77555 0725, USA
    Endocrinology 145:1342-8. 2004
    b>Apelin is a recently discovered peptide that is the endogenous ligand for the APJ receptor...
  18. ncbi Modification of the terminal residue of apelin-13 antagonizes its hypotensive action
    Dennis K Lee
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 146:231-6. 2005
    The apelin peptide is the endogenous ligand for the apelin G protein-coupled receptor...
  19. doi Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1
    Qi Feng Liu
    Department of Cardiology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China
    Biochem Biophys Res Commun 439:235-40. 2013
    b>Apelin-13 plays an important role in the migration and proliferation of vascular smooth muscle cells (VSMCs); however, the underlying mechanisms are still unclear...
  20. doi Apelin-13 protects against myocardial infarction-induced myocardial fibrosis
    Xuemin Zhang
    Department of Cardiology, Shenyang First People s Hospital, Shenyang, Liaoning 110041, P R China
    Mol Med Rep 13:5262-8. 2016
    Myocardial infarction is a serious health threat. Apelin is an endogenous ligand of angiotensin II receptor-like 1 (APJ) and the apelin/APJ system is associated with various types of heart disease...
  21. doi Central apelin mediates stress-induced gastrointestinal motor dysfunction in rats
    Mehmet Bulbul
    Akdeniz University Faculty of Medicine Department of Physiology, Antalya, Turkey and
    Am J Physiol Gastrointest Liver Physiol 310:G249-61. 2016
    b>Apelin, an endogenous ligand for APJ receptor, has been reported to be upregulated in paraventricular nucleus (PVN) following stress. Central apelin is known to stimulate release of corticotropin-releasing factor (CRF) via APJ receptor...
  22. doi Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition
    Sylvain Mayeur
    Unité Environnement Périnatal et Santé, Equipe d accueil 4489, équipe malnutrition maternelle et programmation des maladies métaboliques, Universite de Lille, Villeneuve d Ascq, France
    Diabetes 65:554-60. 2016
    ..Growing evidences indicate that apelin and its receptor, APJ, which are expressed across a wide range of tissues, exert important roles in glucose ..
  23. doi Apelin effects on blood pressure and RAS in DOCA-salt-induced hypertensive rats
    Raziye Akcılar
    Department of Physiology, Faculty of Medicine, University of Dumlupinar, Kutahya, Turkey
    Clin Exp Hypertens 35:550-7. 2013
    b>Apelin, a novel multifunctional peptide implicated in the regulation of the cardiovascular system, including blood pressure and cardiac function control, has been postulated to be involved in the pathophysiology of hypertension and ..
  24. doi Apelin protects sarcoplasmic reticulum function and cardiac performance in ischaemia-reperfusion by attenuating oxidation of sarcoplasmic reticulum Ca2+-ATPase and ryanodine receptor
    Chen Wang
    Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, ChangLeXi Road, Xi an 710032, China
    Cardiovasc Res 100:114-24. 2013
    b>Apelin, an endogenous cytokine, has a number of biological effects on the cardiovascular system, including a cardioprotective effect and calcium modulation...
  25. doi Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy
    Feng Xie
    Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, University of South China, Hengyang 421001, China
    Acta Biochim Biophys Sin (Shanghai) 47:969-80. 2015
    b>Apelin is highly expressed in rat left ventricular hypertrophy Sprague Dawley rat models, and it plays a crucial role in the cardiovascular system...
  26. ncbi Early-effect of bariatric surgery (Scopinaro method) on intestinal hormones and adipokines in insulin resistant Wistar rat
    N Dib
    Department of General, Oncological and Gastrointestinal Surgery, Orlowski Hospital MCPE, Warsaw, Poland
    J Physiol Pharmacol 64:571-7. 2013
    ..Concluding, model studies on rats allowed better understanding of mechanisms important for early normalization of glycemic index and insulin resistance reduction in rats. ..
  27. doi Decreased apelin and apelin-receptor expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia
    Alejandro D Hofmann
    National Children s Research Centre, Our Lady s Children s Hospital, Crumlin, Dublin 12, Ireland
    Pediatr Surg Int 30:197-203. 2014
    ..b>Apelin (APLN), a target gene of bone morphogenic protein receptor 2 (BMPR2), is known to play an important and manifold ..
  28. pmc Apelin-13 inhibits large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent mechanism
    Amit Modgil
    Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, United States of America
    PLoS ONE 8:e83051. 2013
    b>Apelin-13 causes vasoconstriction by acting directly on APJ receptors in vascular smooth muscle (VSM) cells; however, the ionic mechanisms underlying this action at the cellular level remain unclear...
  29. pmc Regulation of apelin and its receptor expression in adipose tissues of obesity rats with hypertension and cultured 3T3-L1 adipocytes
    Hongxian Wu
    Department of Cardiology, Shanghai First People s Hospital, Shanghai Jiao Tong University, Shanghai, P R China
    Exp Anim 63:257-67. 2014
    The apelin/APJ system has been implicated in obesity-related hypertension...
  30. pmc Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine
    Emilie Ceraudo
    From the Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, INSERM U1050, Paris F 75005, France, the Center for Interdisciplinary Research in Biology, College de France, Paris F 75005, France, CNRS, UMR 7241, Paris F 75005, France, and
    J Biol Chem 289:24599-610. 2014
    b>Apelin plays a prominent role in body fluid and cardiovascular homeostasis...
  31. doi Apelin-13 upregulates Egr-1 expression in rat vascular smooth muscle cells through the PI3K/Akt and PKC signaling pathways
    Qi Feng Liu
    Department of Cardiology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, China
    Biochem Biophys Res Commun 468:617-21. 2015
    Previous studies have shown that Apelin-13 upregulates early growth response factor-1 (Egr-1) via the extracellular signal-regulated protein kinase (ERK) signaling pathway...
  32. pmc Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes
    Aung Than
    From the Bioengineering Program, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457
    J Biol Chem 290:14679-91. 2015
    ..b>Apelin is an adipocyte-derived hormone that plays important roles in energy metabolism...
  33. doi High-fat diet and chronic stress reduce central pressor and tachycardic effects of apelin in Sprague-Dawley rats
    Agnieszka Cudnoch-Jedrzejewska
    Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland
    Clin Exp Pharmacol Physiol 42:52-62. 2015
    Central application of apelin elevates blood pressure and influences neuroendocrine responses to stress and food consumption...
  34. doi Investigation of changes in apelin receptor mRNA and protein expression in the myocardium and aorta of rats with two-kidney, one-clip (2K1C) Goldblatt hypertension
    Hamid Najafipour
    Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
    J Physiol Biochem 71:165-75. 2015
    Experimental and clinical evidences suggest that apelin and its receptor APJ are involved in the pathogenesis of cardiovascular complications. However, the role of apelin/APJ in hypertension is not sufficiently understood...
  35. doi Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus
    G Erdem
    Department of Internal Medicine, Gulhane School of Medicine, Etlik, Ankara, Turkey
    Exp Clin Endocrinol Diabetes 116:289-92. 2008
    To investigate blood apelin concentrations in patients with newly diagnosed and untreated type 2 diabetes mellitus (T2DM) who had no additional disorder and to investigate the association of apelin with adiponectin, body mass indexes (BMI)..
  36. ncbi [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]
    Zhen Gui Huang
    Department of Pharmacology and Pharmacology of Traditional Chinese Medicine Grade Three Laboratory, State Administration of Traditional Chinese Medicine of China, Wannan Medical College, Wuhu 241002, China
    Zhongguo Zhong Yao Za Zhi 38:381-5. 2013
    To explore the effect of puerarin combined with felodipine on the mRNA and protein expression of apelin and APJ in renal tissue of renovascular hypertensive rat.
  37. ncbi [Effect of swimming exercise on the expression of apelin and its receptor in pulmonary tissues of rats with hypoxic pulmonary hypertension]
    Si Chen
    Laboratory of Cor Pulmonale, Institute of Hypoxia Medicine, Wenzhou 325035, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 28:5-8. 2012
    To study the effects of swimming exercise on the expression of apelin and its receptor (APJ) system in pulmonary tissues of rats with pulmonary hypertension induced by hypoxia.
  38. doi Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat
    Joanna Ivars
    Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Equipe dénutritions maternelles périnatales, Universite de Lille 1, Bâtiment SN4, F 59655 Villeneuve d Ascq, France
    Peptides 35:136-8. 2012
    b>Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown...
  39. doi Apelin supports primary rat retinal Müller cells under chemical hypoxia and glucose deprivation
    Xin lei Wang
    Department of Ophthalmology, People s Hospital, Peking University, and Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100044, China
    Peptides 33:298-306. 2012
    ..The apelin peptide, as the endogenous ligand of G protein-coupled receptor APJ, participates in numbers of physiological and ..
  40. doi Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs
    Shino Ohno
    Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, Kawagoe City, Saitama, Japan
    Regul Pept 174:71-8. 2012
    b>Apelin is a peptide that was originally isolated from bovine stomach extract and has been demonstrated to be an endogenous ligand for orphan receptor APJ. Both apelin and the APJ receptor are widely distributed in the whole body...
  41. doi Glomerular expression of apelin and its association with proteinuria
    Yan Bo
    Department of Medical Technology, Anhui Medical College, Hefei, China
    Indian J Pediatr 79:1028-32. 2012
    To investigate the distribution and expression of apelin in kidney of adriamycin (ADR)-induced nephrotic rats, and to explore the possible association of apelin expression with the development of proteinuria.
  42. doi Up-regulation of apelin in brain tissue of patients with epilepsy and an epileptic rat model
    Xiaogang Zhang
    Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, 1st Youyi Road, Chongqing 400016, China
    Peptides 32:1793-9. 2011
    ..The aim of this study was to investigate the expression of the apelin, a novel neuroprotective peptide, in brain tissues of the patients with temporal lobe epilepsy (TLE) and ..
  43. doi Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus
    Federico Soriguer
    Servicio de Endocrinologia y Nutricion, Hospital Regional Universitario Carlos Haya, Malaga, Spain
    Obes Surg 19:1574-80. 2009
    The physiological role of apelin in obesity and diabetes remains unclear. Although apelin has been studied in persons with different conditions, no studies have yet examined the joint influence of obesity and diabetes on apelin levels...
  44. pmc Apelin increases contractility in failing cardiac muscle
    Tieying Dai
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Tower 711, 600 N Wolfe Street, Baltimore, MD 21287, United States
    Eur J Pharmacol 553:222-8. 2006
    b>Apelin, a ligand for apelin-angiotension receptor-like 1 (APJ), has recently been shown to be a potent positive inotropic agent in normal hearts...
  45. ncbi Regulation of rat APJ receptor messenger ribonucleic acid expression in magnocellular neurones of the paraventricular and supraopric nuclei by osmotic stimuli
    A M O'Carroll
    University Research Centre for Neuroendocrinology, University of Bristol, Bristol, UK
    J Neuroendocrinol 15:661-6. 2003
    The novel apelin receptor (APJ receptor, APJR) has a restricted expression in the central nervous system suggestive of an involvement in the regulation of body fluid homeostasis...
  46. ncbi Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats
    Xing Cheng
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Eur J Pharmacol 470:171-5. 2003
    b>Apelin is an endogenous depressor peptide for the G protein-coupled APJ receptor. Our hypothesis is that apelin is a venodilator, and it reduces mean circulatory filling pressure (MCFP; index of venous tone)...
  47. ncbi Intracerebroventricular injection of apelin-13 reduces food intake in the rat
    David Sunter
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Neurosci Lett 353:1-4. 2003
    b>Apelin is a peptide recently identified as a ligand for the APJ receptor, a receptor located in tissues such as the small intestine and in the hypothalamus...
  48. ncbi Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors
    Dennis K Lee
    Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, USA
    J Biol Chem 279:7901-8. 2004
    Signaling of the apelin, angiotensin, and bradykinin peptides is mediated by G protein-coupled receptors related through structure and similarities of physiological function...
  49. ncbi Dehydration-induced cross-regulation of apelin and vasopressin immunoreactivity levels in magnocellular hypothalamic neurons
    Annabelle Reaux-Le Goazigo
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, Room 896, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Endocrinology 145:4392-400. 2004
    b>Apelin, a neuropeptide recently identified as the endogenous ligand for the G protein-coupled receptor APJ, is highly concentrated in brain structures involved in the control of body fluid homeostasis including the supraoptic (SON) and ..
  50. pmc Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release
    Nadia De Mota
    Institut National de la Sante et de la Recherche Medicale, Unite 36, College de France, 75231 Paris, France
    Proc Natl Acad Sci U S A 101:10464-9. 2004
    b>Apelin, a recently isolated neuropeptide that is expressed in the supraoptic and the paraventricular nuclei, acts on specific receptors located on vasopressinergic neurons...
  51. ncbi Behavioral, neuroendocrine and thermoregulatory actions of apelin-13
    M Jászberényi
    Department of Pathophysiology, University of Szeged, Neurohumoral Research Group, Hungarian Academy of Sciences, Semmelweis u 1, PO Box 427, H 6701, Szeged, Hungary
    Neuroscience 129:811-6. 2004
    As the distribution of apelinergic neurons in the brain suggests an important role of apelin-13 in the regulation of neuroendocrine processes, in the present experiments the effects of this recently identified neuropeptide on the open-..
  52. ncbi Central and peripheral cardiovascular actions of apelin in conscious rats
    Shuntaro Kagiyama
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Regul Pept 125:55-9. 2005
    ..b>Apelin is a peptide that has recently been identified as an endogenous ligand of the APJ...
  53. ncbi Apelin: a new plasma marker of cardiopulmonary disease
    Jens Peter Goetze
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK 2100, Copenhagen, Denmark
    Regul Pept 133:134-8. 2006
    ..We therefore examined whether plasma concentrations of apelin, a novel inotropic hormone, is affected in patients with chronic parenchymal lung disease without cardiac ..
  54. ncbi Apelin protects myocardial injury induced by isoproterenol in rats
    Yue Xia Jia
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Regul Pept 133:147-54. 2006
    We aimed to explore the change in level of apelin and its receptor APJ during myocardial injury and the therapeutic effects of apelin in myocardial injury...
  55. ncbi Reduced apelin levels in lone atrial fibrillation
    Patrick T Ellinor
    Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Boston, MA, USA
    Eur Heart J 27:222-6. 2006
    b>Apelin is an endogenous peptide hormone that appears to have a physiological role in counter-regulation of the angiotensin and vasopressin systems...
  56. ncbi Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells
    Tatsuo Hashimoto
    Division of Cellular Pathobiology, Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, 236 0004, Japan
    Arterioscler Thromb Vasc Biol 26:1267-72. 2006
    Physiological roles of apelin and its specific receptor APJ signaling were investigated in vascular smooth muscle cells (VSMCs)...
  57. ncbi Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats
    Anaya Mitra
    Department of Psychology, University of Florida, Gainesville, FL 32611 2250, USA
    Physiol Behav 89:221-5. 2006
    Previous studies have indicated that apelin, a novel peptide suggested to have some actions related to angiotensin peptides, has either a dipsogenic or an antidipsogenic effect and either increases or decreases blood pressure...
  58. ncbi Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release
    Annabelle Reaux-Le Goazigo
    Institut National de la Sante et de la Recherche Medicale, Unité 691, College de France, 11 place Marcelin Berthelot, Paris, France
    Am J Physiol Endocrinol Metab 292:E7-15. 2007
    b>Apelin is a bioactive peptide recently identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ...
  59. pmc Ontogeny of apelin and its receptor in the rodent gastrointestinal tract
    Guiyun Wang
    Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555, USA
    Regul Pept 158:32-9. 2009
    b>Apelin is the endogenous ligand for the APJ receptor and both apelin and APJ are expressed in the gastrointestinal (GI) tract...
  60. ncbi Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers
    Diego García-Díaz
    Department of Physiology and Nutrition, University of Navarra, C Irunlarrea s n, 31008, Pamplona, Spain
    Mol Cell Biochem 305:87-94. 2007
    It has been reported that apelin functions as an adipokine, which has been associated to obesity and insulin resistance...
  61. ncbi Characterization of the 5'-regulatory regions of the rat and human apelin genes and regulation of breast apelin by USF
    Guiyun Wang
    Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA
    FASEB J 20:2639-41. 2006
    b>Apelin, a peptide widely expressed in the body, is the endogenous ligand for the APJ receptor...
  62. doi Effect of apelin on glomerular hemodynamic function in the rat kidney
    Annette Hus-Citharel
    INSERM, U 691, Paris, France
    Kidney Int 74:486-94. 2008
    b>Apelin is a vasoactive peptide identified as the endogenous ligand of an orphan G protein-coupled receptor called APJ. Apelin and its receptor have been found in the brain and the cardiovascular system...
  63. doi The hepatic apelin system: a new therapeutic target for liver disease
    Alessandro Principe
    Biochemistry and Molecular Genetics Service, Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas CIBERehd, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Hepatology 48:1193-201. 2008
    b>Apelin is a peptide that plays an important role in heart physiology and pathophysiology, inflammation, and angiogenesis...
  64. pmc Involvement of a Stat3 binding site in inflammation-induced enteric apelin expression
    Song Han
    Dept of Surgery, Univ of Texas Medical Branch, Galveston, TX 77555, USA
    Am J Physiol Gastrointest Liver Physiol 295:G1068-78. 2008
    b>Apelin is the endogenous ligand for the APJ receptor; both are expressed in the gastrointestinal tract. Experimental colitis in rodents and inflammatory bowel disease in humans are associated with increased intestinal apelin production...
  65. ncbi Reduced apelin levels in stable angina
    Zhao Li
    Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, China
    Intern Med 47:1951-5. 2008
    To investigate the change in the plasma apelin level in patients with stable angina.
  66. ncbi Direct effects of apelin on cardiomyocyte contractility and electrophysiology
    Klára Farkasfalvi
    Heart Science Centre, Laboratory of Cell Electrophysiology, NHLI, Imperial College London, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK
    Biochem Biophys Res Commun 357:889-95. 2007
    b>Apelin, the ligand for the angiotensin receptor like-1, has been implicated in the pathogenesis of atrial fibrillation and heart failure...
  67. doi Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension
    Ines Falcao-Pires
    Department of Physiology, Cardiovascular R and D Unit, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
    Am J Physiol Heart Circ Physiol 296:H2007-14. 2009
    We investigated the endogenous production of apelin and the cardiac and pulmonary effects of its chronic administration in monocrotaline (MCT)-induced pulmonary hypertension (PH)...
  68. doi Data supporting a new physiological role for brain apelin in the regulation of hypothalamic oxytocin neurons in lactating rats
    Laurence Bodineau
    Institut National de la Sante et de la Recherche Medicale, Paris F 75231, France
    Endocrinology 152:3492-503. 2011
    b>Apelin is a bioactive peptide identified as the endogenous ligand of the human orphan G protein-coupled receptor APJ in 1998...
  69. doi Maternal apelin physiology during rat pregnancy: the role of the placenta
    T Van Mieghem
    Department of Obstetrics and Gynecology, Health Campus Gasthuisberg, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Placenta 31:725-30. 2010
    b>Apelin is a multifunctional peptide which is catabolized by the angiotensin-converting enzyme-related carboxypeptidase-2 (ACE2). The peptide is well known for its hemodynamic effects and its role in energy and fluid homeostasis...
  70. ncbi Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression
    Pavan Atluri
    Division of Cardiothoracic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Mol Biol Lett 12:127-38. 2007
    b>Apelin interacts with the APJ receptor to enhance inotropy. In heart failure, apelin-APJ coupling may provide a means of enhancing myocardial function...
  71. doi Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment?
    Ines Falcao-Pires
    University of Porto, Department of Physiology, Cardiovascular R and D Unit, Faculty of Medicine, 4200 319 Porto, Portugal
    Expert Opin Ther Targets 14:231-41. 2010
    ..To investigate the effects of left ventricular (LV) pressure overload and diabetes on the apelinergic system...
  72. ncbi Increased colonic apelin production in rodents with experimental colitis and in humans with IBD
    Song Han
    Department of Surgery, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0725, USA
    Regul Pept 142:131-7. 2007
    b>Apelin and its receptor, the APJ receptor, are expressed in the gastrointestinal tract...