AMP activated protein kinase

Summary

Gene Symbol: AMP activated protein kinase
Description: protein kinase AMP-activated catalytic subunit alpha 2
Alias: Ampk, Ampka2, 5'-AMP-activated protein kinase catalytic subunit alpha-2, ACACA kinase, AMP-activated protein kinase, AMPK alpha-2 chain, AMPK subunit alpha-2, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, protein kinase, AMP-activated, alpha 2 catalytic subunit
Species: rat

Top Publications

  1. pmc AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF
    Seán M Kilbride
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    J Biol Chem 285:36199-206. 2010
  2. ncbi Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
    S A Hawley
    Biochemistry Department, The University, Dundee DD1 4HN, Scotland, United Kingdom
    J Biol Chem 271:27879-87. 1996
  3. ncbi The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
    A Woods
    MRC Molecular Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    FEBS Lett 397:347-51. 1996
  4. pmc Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding
    P C Cheung
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Biochem J 346:659-69. 2000
  5. ncbi Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
    A S Marsin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
    Curr Biol 10:1247-55. 2000
  6. ncbi Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
    R Bergeron
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Am J Physiol Endocrinol Metab 281:E1340-6. 2001
  7. ncbi Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate
    John W Scott
    Division of Molecular Physiology, School of Life Sciences and Wellcome Trust Biocentre, Dundee University, Scotland, UK
    J Mol Biol 317:309-23. 2002
  8. ncbi AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
    Douglas R Bolster
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 277:23977-80. 2002
  9. ncbi Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
    Haejoe Park
    Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 277:32571-7. 2002
  10. ncbi Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes
    Ulrike Krause
    Hormone and Metabolic Research Unit, Christian de Duve International Institute of Cellular and Molecular Pathology and University of Louvain Medical School, Brussels, Belgium
    Eur J Biochem 269:3751-9. 2002

Research Grants

  1. VisualSonics Vevo 770 Imaging System
    Lawrence Young; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. pmc AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF
    Seán M Kilbride
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    J Biol Chem 285:36199-206. 2010
    ..This was coupled with activation of the bioenergetic stress sensor AMP-activated protein kinase (AMPK), which preceded the onset of apoptosis...
  2. ncbi Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
    S A Hawley
    Biochemistry Department, The University, Dundee DD1 4HN, Scotland, United Kingdom
    J Biol Chem 271:27879-87. 1996
    ..A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., and Hardie, D. G. (1995) J. Biol. Chem. 270, 27186-27191)...
  3. ncbi The alpha1 and alpha2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro
    A Woods
    MRC Molecular Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    FEBS Lett 397:347-51. 1996
    The AMP-activated protein kinase (AMPK) is a heterotrimeric complex composed of a catalytic subunit (alpha) and two regulatory subunits (beta and gamma). Two isoforms of the catalytic subunit (alpha1 and alpha2) have been identified...
  4. pmc Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding
    P C Cheung
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, U K
    Biochem J 346:659-69. 2000
    The AMP-activated protein kinase (AMPK) cascade plays an important role in the regulation of energy homeostasis within the cell. AMPK is a heterotrimer composed of a catalytic subunit (alpha) and two regulatory subunits (beta and gamma)...
  5. ncbi Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
    A S Marsin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
    Curr Biol 10:1247-55. 2000
    ..The AMP-activated protein kinase (AMPK) is activated when the oxygen supply is restricted...
  6. ncbi Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
    R Bergeron
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Am J Physiol Endocrinol Metab 281:E1340-6. 2001
    ..ATP, and ATP/AMP ratios were all markedly decreased and led to the activation of AMP-activated protein kinase (AMPK) in the beta-GPA-fed rats compared with control rats...
  7. ncbi Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate
    John W Scott
    Division of Molecular Physiology, School of Life Sciences and Wellcome Trust Biocentre, Dundee University, Scotland, UK
    J Mol Biol 317:309-23. 2002
    We have expressed a truncated form of the alpha1 kinase domain of AMP-activated protein kinase (AMPK) in Escherichia coli as a glutathione-S-transferase fusion (GST-KD)...
  8. ncbi AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
    Douglas R Bolster
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 277:23977-80. 2002
    AMP-activated protein kinase (AMPK) is viewed as an energy sensor that acts to modulate glucose uptake and fatty acid oxidation in skeletal muscle...
  9. ncbi Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
    Haejoe Park
    Diabetes Unit, Section of Endocrinology and Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA
    J Biol Chem 277:32571-7. 2002
    ..acyltransferase (GPAT), which like MCD and ACC can be regulated by AMP-activated protein kinase (AMPK), was assayed...
  10. ncbi Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes
    Ulrike Krause
    Hormone and Metabolic Research Unit, Christian de Duve International Institute of Cellular and Molecular Pathology and University of Louvain Medical School, Brussels, Belgium
    Eur J Biochem 269:3751-9. 2002
    ..In contrast, the AMP-activated protein kinase (AMPK), which senses the energy state of the cell and becomes activated under metabolic stress, inactivates by ..
  11. ncbi Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle
    S H Park
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah 84602, USA
    J Appl Physiol (1985) 93:2081-8. 2002
    AMP-activated protein kinase (AMPK) consists of three subunits: alpha, beta, and gamma...
  12. ncbi Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise
    David L Coven
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Physiol Endocrinol Metab 285:E629-36. 2003
    AMP-activated protein kinase (AMPK) is emerging as a key signaling pathway that modulates cellular metabolic processes. In skeletal muscle, AMPK is activated during exercise...
  13. ncbi Management of cellular energy by the AMP-activated protein kinase system
    D Grahame Hardie
    Division of Molecular Physiology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 546:113-20. 2003
    ..A survey of the range of downstream targets for this important signalling pathway is presented...
  14. ncbi Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase
    Samar I Itani
    Diabetes and Metabolism Unit and Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    Diabetes 52:1635-40. 2003
    ..Activation of the energy-sensing enzyme AMP-activated protein kinase (AMPK) has been shown to increase insulin-independent glucose transport into skeletal muscle in response to such stimuli ..
  15. ncbi AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation
    Daisuke Nagata
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circulation 110:444-51. 2004
    AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that works as a metabolic sensor of cellular ATP levels...
  16. ncbi Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity
    Ulrika Andersson
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, DuCane Road, London W12 0NN, UK
    Biochem Biophys Res Commun 329:719-25. 2005
    Recent studies have demonstrated that AMP-activated protein kinase (AMPK) in the hypothalamus is involved in the regulation of food intake...
  17. ncbi AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle
    Nobuharu Fujii
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:39033-41. 2005
    To examine the role of AMP-activated protein kinase (AMPK) in muscle glucose transport, we generated muscle-specific transgenic mice (TG) carrying cDNAs of inactive alpha2 (alpha2i TG) and alpha1 (alpha1i TG) catalytic subunits...
  18. ncbi Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491
    Sandrine Horman
    Hormone and Metabolic Research Unit, Christian de Duve Institute of Cellular Pathology and Universite catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    J Biol Chem 281:5335-40. 2006
    ....
  19. ncbi AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
    Luc Bertrand
    Division of Cardiology, School of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Heart Circ Physiol 291:H239-50. 2006
    ..Part of these metabolic effects is thought to be mediated by the activation of AMP-activated protein kinase (AMPK)...
  20. ncbi Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    Andrew L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
    Diabetes 55:2688-97. 2006
    ..Furthermore, IL-6 rapidly and markedly increased AMP-activated protein kinase (AMPK)...
  21. pmc Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes
    Ho Jin Koh
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Biochem J 403:473-81. 2007
    Exercise increases AMPK (AMP-activated protein kinase) activity in human and rat adipocytes, but the underlying molecular mechanisms and functional consequences of this activation are not known...
  22. pmc Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
    Richard M Reznick
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 5:151-6. 2007
    ..Given the important role of the AMP-activated protein kinase (AMPK) in the regulation of fat oxidation and mitochondrial biogenesis, we examined AMPK activity in young and old rats ..
  23. ncbi A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss
    Eduardo R Ropelle
    Department of Internal Medicine, State University of Campinas UNICAMP, 13083 970, Campinas, Sao Paulo, Brazil
    Diabetes 57:594-605. 2008
    ..AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) function as majors regulators of cellular metabolism that respond to ..
  24. doi Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase
    Bettina Johanna Stuck
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, D 66421 Homburg Saar, Germany
    J Biol Chem 283:32562-9. 2008
    ..of angiotensin II on glucose and fatty acid utilization and the modifying role of AMP-activated protein kinase (AMPK), a key regulator of metabolism and proliferation...
  25. pmc Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Nat Med 16:1001-8. 2010
    ..administration of triiodothyronine (T3) decreases the activity of hypothalamic AMP-activated protein kinase (AMPK), increases sympathetic nervous system (SNS) activity and upregulates thermogenic markers in brown adipose tissue (..
  26. pmc AMPK activation increases uncoupling protein-3 expression and mitochondrial enzyme activities in rat muscle without fibre type transitions
    Charles T Putman
    Exercise Biochemistry Laboratory, Faculty of Physical Education, University of Alberta, E 417 Van Vliet Centre, Edmonton, Alberta, Canada T6G 2H9
    J Physiol 551:169-78. 2003
    The present study examined the effect of chronic activation of 5'-AMP-activated protein kinase (AMPK) on the metabolic profile, including uncoupling protein-3 (UCP-3) and myosin heavy chain (MHC)-based fibre phenotype of rodent fast-..
  27. doi Berberine acutely inhibits insulin secretion from beta-cells through 3',5'-cyclic adenosine 5'-monophosphate signaling pathway
    Libin Zhou
    Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai 200025, People s Republic of China
    Endocrinology 149:4510-8. 2008
    Berberine, a hypoglycemic agent, has recently been shown to activate AMP-activated protein kinase (AMPK) contributing to its beneficial metabolic effects in peripheral tissues...
  28. pmc Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    Simon A Hawley
    Division of Molecular Physiology, University of Dundee, Dundee DD1 5EH, UK
    J Biol 2:28. 2003
    The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation...
  29. ncbi Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
    Gareth J Browne
    Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 279:12220-31. 2004
    ..An important regulator of energy supply and demand in eukaryotic cells is the AMP-activated protein kinase (AMPK)...
  30. ncbi Possible involvement of the alpha1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle
    Taro Toyoda
    Dept of Medicine and Clinical Science, Kyoto Univ Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto, 606 8507, Japan
    Am J Physiol Endocrinol Metab 287:E166-73. 2004
    Recent studies have suggested that 5'AMP-activated protein kinase (AMPK) is activated in response to metabolic stresses, such as contraction, hypoxia, and the inhibition of oxidative phosphorylation, which leads to insulin-independent ..
  31. ncbi High-fat diet feeding impairs both the expression and activity of AMPKa in rats' skeletal muscle
    Yi Liu
    Shandong Provincial Hospital Shandong University, Jinan 250021, China
    Biochem Biophys Res Commun 339:701-7. 2006
    To investigate the effects of high-fat feeding on the expression and activity of AMPK in rats' skeletal muscle.
  32. pmc AMPK represses TOP mRNA translation but not global protein synthesis in liver
    Ali K Reiter
    Department of Cellular and Molecular Physiology, The Pennsylvania State College of Medicine, PO Box 850, Hershey, PA 17033, USA
    Biochem Biophys Res Commun 374:345-50. 2008
    The AMP-activated protein kinase (AMPK) represses signaling through the mammalian target of rapamycin complex 1 (mTORC1). In muscle, repression of mTORC1 leads to a reduction in global protein synthesis...
  33. doi Curcumin decreases renal triglyceride accumulation through AMPK-SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats
    Vivian Soetikno
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956 8603, Japan
    J Nutr Biochem 24:796-802. 2013
    ..the tissue dyslipidemic condition through activation of 5' adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and suppression of sterol regulatory element-binding protein (SREBP)-1c in the kidney and would ..
  34. pmc FoxO1 and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell-cycle withdrawal and IGF1 gene regulation
    Arunima Sengupta
    The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, Cincinnati, OH 45229, USA
    Circ Res 112:267-77. 2013
    ..In the mammalian heart, cardiomyocytes withdraw from the cell cycle and initiate hypertrophic growth soon after birth, but the transcriptional regulatory mechanisms that control these neonatal transitions are not well-defined...
  35. doi Metformin induces up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells
    Fuyuko Takata
    Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    Biochem Biophys Res Commun 433:586-90. 2013
    ..These effects of metformin were blocked by compound C, an inhibitor of AMP-activated protein kinase (AMPK). AMPK stimulation with an AMPK activator, AICAR, enhanced BBB functions...
  36. doi Long-term effect of green tea extract during lactation on AMPK expression in rat offspring exposed to fetal malnutrition
    Shin Sato
    Department of Nutrition, Aomori University of Health and Welfare, Aomori, Japan
    Nutrition 29:1152-8. 2013
    ..whether maternal green tea extract (GTE) intake during lactation affects the expression and activity of adenosine monophosphate-activated protein kinase (AMPK) in the kidneys of male offspring of protein-restricted dams during gestation.
  37. pmc Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress
    H He
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People s Republic of China
    Cell Death Dis 5:e997. 2014
    ..stress-induced activation of calcineurin contributes to the attenuation of adaptive AMP-activated protein kinase (AMPK) signalling and inhibits autophagy in cardiomyocytes...
  38. pmc Effects of modulators of AMP-activated protein kinase on TASK-1/3 and intracellular Ca(2+) concentration in rat carotid body glomus cells
    Donghee Kim
    Department of Physiology and Biophysics, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, United States Electronic address
    Respir Physiol Neurobiol 195:19-26. 2014
    ..Recent studies suggest that AMP-activated protein kinase (AMPK) mediates these effects of hypoxia by inhibiting the background K(+) channels such as TASK...
  39. doi AMP-activated protein kinase activation leads to lysome-mediated NA(+)/I(-)-symporter protein degradation in rat thyroid cells
    J M Cazarin
    Laboratório de Fisiologia Endócrina, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Horm Metab Res 46:313-7. 2014
    ..Recently, our group showed that AMP-activated protein kinase (AMPK) plays a pivotal role in the rat thyroid gland, downregulating iodide uptake, NIS protein, and mRNA content...
  40. pmc The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network
    Martial Boutchueng-Djidjou
    From the Département de Pédiatrie, Laboratoire de Biologie Cellulaire
    Mol Cell Proteomics 14:1079-92. 2015
    ..The IR interactome (IRGEN) connects ATIC to AMPK within the Golgi/endosome protein network (GEN)...
  41. doi HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis
    Kyung Don Ju
    Institute of Biomedical Research, Seoul National University Hospital, Seoul, Korea
    Am J Physiol Renal Physiol 310:F342-50. 2016
    HL156A is a novel AMP-activated protein kinase (AMPK) activator. We aimed to investigate the protective mechanism of HL156A against peritoneal fibrosis (PF) in in vivo and in vitro models...
  42. ncbi A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population
    Momoko Horikoshi
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 55:919-23. 2006
    AMP-activated protein kinase (AMPK) acts as a fuel gauge for glucose and lipid metabolism...
  43. ncbi Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts
    Adrian Chabowski
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Mol Cell Biochem 288:201-12. 2006
    ..When the AICAR-induced AMPK phosphorylation was blocked, neither FAT/CD36 nor FABPpm were overexpressed, nor were palmitate uptake and ..
  44. pmc ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration
    Roberta Martinelli
    Division of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Mol Biol Cell 20:995-1005. 2009
    ..S1177 in response to ICAM-1 activation was regulated by src family protein kinase, rho GTPase, Ca(2+), CaMKK, and AMPK, but not Akt/PI3K...
  45. pmc Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization
    Meghan Kelly
    Department of Medicine, Section of Endocrinology, Diabetes Research Unit, Boston University School of Medicine, Boston, Massachusetts, USA
    Diabetes 58:1953-60. 2009
    Interleukin-6 (IL-6) directly activates AMP-activated protein kinase (AMPK) in vivo and in vitro; however, the mechanism by which it does so is unknown.
  46. doi Anti-inflammatory and anticarcinogenic effect of genistein alone or in combination with capsaicin in TPA-treated rat mammary glands or mammary cancer cell line
    Jin Tack Hwang
    Korea Food Research Institute, Seongnam, Gyungki do, Korea
    Ann N Y Acad Sci 1171:415-20. 2009
    ..alone or in combination with capsaicin in inhibiting breast cancer cell proliferation through the modulation of AMPK and COX-2 were tested. AMPK activation by genistein in combination with capsaicin is critical for inhibiting COX-2...
  47. pmc AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
    M Shah
    Department of Veterinary Basic Sciences Royal Veterinary College, Royal College Street, London, NW1 OTU, UK
    Bone 47:309-19. 2010
    Adenosine 5'-monophosphate-activated protein kinase (AMPK), a regulator of energy homeostasis, has a central role in mediating the appetite-modulating and metabolic effects of many hormones and antidiabetic drugs metformin and glitazones...
  48. ncbi The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate
    Nathan P Manes
    Department of Physiology and Biophysics, Stony Brook University, NY 11794 8661, USA
    Arch Biochem Biophys 438:125-36. 2005
    ..We also found that AMP activated protein kinase and protein kinases A, B, and C catalyzed the phosphorylation of Ser-460 of HBP1, and that in addition ..
  49. ncbi AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2
    Vivek Bhalla
    Division of Nephrology, Department of Medicine, University of California at San Francisco, San Francisco, California 94107, USA
    J Biol Chem 281:26159-69. 2006
    We recently found that the metabolic sensor AMP-activated kinase (AMPK) inhibits the epithelial Na+ channel (ENaC) through decreased plasma membrane ENaC expression, an effect requiring the presence of a binding motif in the cytoplasmic ..
  50. ncbi [Effects of AMPK on the transcriptional activity of FOXO1 and ubiquitin ligase MuRF1 expression in rat cardiomyocytes]
    Bao Lin Chen
    Department of Cardiology, People s Hospital of Guizhou Province, Guiyang 550002, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:2419-22. 2010
    To investigate the effects of AICAR on the activity of transcription factor FOXO1 and expression of ubiquitin ligase MuRF1 in rat cardiomyocytes, and explore the possible role of AMP-activated protein kinase (AMPK) in proteolysis pathways.
  51. doi A role for hypothalamic AMP-activated protein kinase in the mediation of hyperphagia and weight gain induced by chronic treatment with olanzapine in female rats
    Ei Sejima
    Department of Pharmaceutical Care and Health Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    Cell Mol Neurobiol 31:985-9. 2011
    ..olanzapine (2 mg/kg) or vehicle once a day for 2 weeks to ascertain if hypothalamic AMP-activated protein kinase (AMPK) mediates olanzapine-induced weight gain and hyperphagia...
  52. doi The role of AMPKα in high-glucose-induced dysfunction of cultured rat mesangial cells
    Zhi Mei Lv
    Department of Nephrology, Provincial Hospital affiliated to Shandong University, Jinan, China
    Ren Fail 34:616-21. 2012
    Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is known as a mammalian cell energy sensor, which could regulate cellular energy metabolism via sensing the alterations of energy balance, such as oversupply or lack of ..
  53. doi Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant
    Somasundaram Arumugam
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City 956 8603, Japan
    Exp Mol Pathol 93:183-9. 2012
    ..Recently much attention has been paid to studying the involvement of AMP-activated protein kinase (AMPK) and mitogen activated protein kinase (MAPK) in various cardiovascular ailments...
  54. pmc AMPK attenuates microtubule proliferation in cardiac hypertrophy
    John T Fassett
    Cardiovascular Division, University of Minnesota Medical School, Minneapolis, MN, USA
    Am J Physiol Heart Circ Physiol 304:H749-58. 2013
    ..b>AMPK limits anabolic processes, such as protein synthesis, when energy supply is insufficient, but its role in ..
  55. pmc Regulation of phosphatidylcholine and phosphatidylethanolamine synthesis in rat hepatocytes by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)
    Martin Houweling
    Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, University of Utrecht, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Biochem J 362:97-104. 2002
    The present study was undertaken to study the role of AMP-activated kinase (AMPK) in the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE)...
  56. ncbi Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes
    Hideyuki Sakoda
    Institute for Adult Disease, Asahi Life Foundation, Tokyo 116, Japan
    Am J Physiol Endocrinol Metab 282:E1239-44. 2002
    5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR) reportedly activates AMP-activated protein kinase (AMPK) and stimulates glucose uptake by skeletal muscle cells...
  57. ncbi Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions
    David C Wright
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 53:330-5. 2004
    It is now generally accepted that activation of AMP-activated protein kinase (AMPK) is involved in the stimulation of glucose transport by muscle contractions...
  58. ncbi Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
    Kei Sakamoto
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Scotland, UK
    Am J Physiol Endocrinol Metab 287:E310-7. 2004
    Activation of AMP-activated protein kinase (AMPK) by exercise and metformin is beneficial for the treatment of type 2 diabetes...
  59. ncbi The metabolic "switch" AMPK regulates cardiac heparin-releasable lipoprotein lipase
    Ding An
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Endocrinol Metab 288:E246-53. 2005
    The "fuel gauge" AMP-activated protein kinase (AMPK) facilitates ATP production to meet energy demands during metabolic stress...
  60. ncbi The AMP-activated protein kinase pathway--new players upstream and downstream
    D Grahame Hardie
    Division of Molecular Physiology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK
    J Cell Sci 117:5479-87. 2004
    The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status...
  61. ncbi Impact of adenoviral transduction with SREBP1c or AMPK on pancreatic islet gene expression profile: analysis with oligonucleotide microarrays
    Frederique Diraison
    Henry Wellcome Signalling Laboratories and Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 ITD, UK
    Diabetes 53:S84-91. 2004
    ..3%) were upregulated. By contrast, overexpression of constitutively active AMP-activated protein kinase (AMPK), expected to promote lipolysis, altered the expression of 752 genes, of which 702 (93%) were upregulated...
  62. ncbi AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270)
    Tristan J Iseli
    St Vincent s Institute, University of Melbourne, Victoria, Australia
    J Biol Chem 280:13395-400. 2005
    AMP-activated protein kinase (AMPK) is an important metabolic stress-sensing protein kinase responsible for regulating metabolism in response to changing energy demand and nutrient supply...
  63. pmc AMP kinase activation with AICAR simultaneously increases fatty acid and glucose oxidation in resting rat soleus muscle
    Angela C Smith
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Physiol 565:537-46. 2005
    5-Amino-4-imidazolecarboxamide riboside (AICAR), a pharmacological activator of AMP-activated protein kinase (AMPK), acutely stimulates glucose uptake and fatty acid (FA) oxidation in skeletal muscle...
  64. ncbi Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase
    Blerina Kola
    Department of Endocrinology, William Harvey Research Institute, Barts and the London Medical School, London EC1M 6BQ, United Kingdom
    J Biol Chem 280:25196-201. 2005
    ..The AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that functions as a fuel sensor to regulate energy balance at both cellular and whole ..
  65. ncbi Chronic rosiglitazone treatment restores AMPKalpha2 activity in insulin-resistant rat skeletal muscle
    Sarah J Lessard
    School of Medical Sciences, RMIT University, Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 290:E251-7. 2006
    ..that part of the insulin-sensitizing effect of RSG is mediated through the action of AMP-activated protein kinase (AMPK)...
  66. pmc Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases
    Michela Capano
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Biochem J 395:57-64. 2006
    ..there was an increase in the active, phosphorylated forms of p38 MAPK (mitogen-activated protein kinase) and AMPK (AMP-activated protein kinase)...
  67. ncbi Extracellular adenosine activates AMP-dependent protein kinase (AMPK)
    Ivette Aymerich
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, 08071 Barcelona, Spain
    J Cell Sci 119:1612-21. 2006
    Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric complex that senses intracellular energy status and exerts rapid regulation on energy-demanding and -consuming metabolic pathways...
  68. ncbi Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation
    Kim Ravnskjaer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    J Mol Endocrinol 36:289-99. 2006
    ..activation of protein phosphatase 2A in a process involving inactivation of the AMP-activated protein kinase (AMPK)...
  69. pmc Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes
    Matthew J Watt
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, RMIT University, Victoria, Australia
    J Physiol 574:139-47. 2006
    We investigated the role of fatty acid availability on AMPK signalling and fatty acid oxidation in skeletal muscle...
  70. ncbi Activation of AMPK alpha- and gamma-isoform complexes in the intact ischemic rat heart
    Ji Li
    Section of Cardiovascular Medicine, 3 FMP, Yale Univ School of Medicine, 333 Cedar St, New Haven, CT 06520 8017, USA
    Am J Physiol Heart Circ Physiol 291:H1927-34. 2006
    AMP-activated protein kinase (AMPK) plays a key role in modulating cellular metabolic processes...
  71. ncbi Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
    Masataka Suwa
    Institute of Health Science, Kyushu University, Kasuga, Fukuoka 816 8580, Japan
    J Appl Physiol (1985) 101:1685-92. 2006
    AMP-activated protein kinase (AMPK), which was activated by an antihyperglycemic drug metformin, has been hypothesized to mediate metabolic adaptations...
  72. ncbi AMPK and metabolic adaptation by the heart to pressure overload
    Michael F Allard
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Rm 166, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
    Am J Physiol Heart Circ Physiol 292:H140-8. 2007
    ..response to reduced energy production from long-chain fatty acid oxidation with 5'-AMP-activated protein kinase (AMPK) functioning as a cellular signal...
  73. ncbi Critical role of 5'-AMP-activated protein kinase in the stimulation of glucose transport in response to inhibition of oxidative phosphorylation
    Ming Jing
    Clinical and Molecular Endocrinology, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
    Am J Physiol Cell Physiol 292:C477-87. 2007
    5'-AMP-activated protein kinase (AMPK) functions as an energy sensor to provide metabolic adaptation under conditions of ATP depletion, such as hypoxia and inhibition of oxidative phosphorylation...
  74. pmc Ligand-regulated peptide aptamers that inhibit the 5'-AMP-activated protein kinase
    Russell A Miller
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Mol Biol 365:945-57. 2007
    ..of ligand-regulated peptide aptamers that interact with and inhibit the 5'-AMP-activated protein kinase (AMPK)...
  75. pmc AMP-activated protein kinase mediates carotid body excitation by hypoxia
    Christopher N Wyatt
    Division of Biomedical Sciences, School of Biology, Bute Building, University of St Andrews, St Andrews, Fife, KY16 9TS, UK
    J Biol Chem 282:8092-8. 2007
    ..We tested the hypothesis that AMP-activated protein kinase (AMPK) is the effector of hypoxic chemotransduction...
  76. ncbi AMPK activation with AICAR provokes an acute fall in plasma [K+]
    Dan Zheng
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, CA 90089 9142, USA
    Am J Physiol Cell Physiol 294:C126-35. 2008
    AMP-activated protein kinase (AMPK), activated by an increase in intracellular AMP-to-ATP ratio, stimulates pathways that can restore ATP levels...
  77. ncbi Chemical hypoxia-induced glucose transporter-4 translocation in neonatal rat cardiomyocytes
    Fu Guan
    Department of Cardiology, The First Affiliated Hospital, China Medical University, Shenyang, China
    Arch Med Res 39:52-60. 2008
    AMP-activated protein kinase (AMPK) activation plays an essential role in glucose metabolism of the heart...
  78. ncbi Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats
    Sanna Oikari
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Pflugers Arch 456:369-77. 2008
    ..in liver and adipose tissue of fed transgenic rats, whereas adenosine monophosphate-activated protein kinase (AMPK) protein levels were increased (by 60%)...
  79. doi Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: potential role of AMPK in the visceral adipose tissue
    Jisook Pang
    Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, 134 Shinchon dong, Sudaemun Ku, Seoul 120 749, South Korea
    Arch Biochem Biophys 476:178-85. 2008
    ..paraguariensis extract protected rats from the HFD-induced decreases in the phospho-AMP-activated protein kinase (AMPK)/AMPK and phospho-acetyl-CoA carboxylase (ACC)/ACC protein ratio related to fatty acid oxidation in the edipidymal ..
  80. doi Glucocorticoids increase neuropeptide Y and agouti-related peptide gene expression via adenosine monophosphate-activated protein kinase signaling in the arcuate nucleus of rats
    Hiroshi Shimizu
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Endocrinology 149:4544-53. 2008
    Recent studies suggest that the AMP-activated protein kinase (AMPK) signaling in the hypothalamus is the master regulator of energy balance...
  81. pmc Fructose-2,6-bisphosphate is lower in copper deficient rat cerebellum despite higher content of phosphorylated AMP-activated protein kinase
    Anna A Gybina
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School Duluth, Duluth, MN 55812, USA
    Exp Biol Med (Maywood) 233:1262-70. 2008
    ..b>AMP activated protein kinase (AMPK) is a cellular energy "master-switch" that is thought to augment glycolysis through ..
  82. pmc Follicle-stimulating hormone inhibits adenosine 5'-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway
    Pradeep P Kayampilly
    Department of Obstetrics and Gynecology and Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Endocrinology 150:929-35. 2009
    ..The present study investigated whether AMP-activated protein kinase (AMPK), which controls the energy balance of the cell, plays a role in FSH-mediated increase in granulosa cell ..
  83. pmc Central exercise action increases the AMPK and mTOR response to leptin
    Eduardo R Ropelle
    Department of Internal Medicine, FCM, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    PLoS ONE 3:e3856. 2008
    AMP-activated protein kinase (AMPK) and mammalian Target of Rapamycin (mTOR) are key regulators of cellular energy balance and of the effects of leptin on food intake...
  84. doi Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats
    Joseph Fomusi Ndisang
    Department of Physiology, University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan, Canada
    Endocrinology 150:2627-36. 2009
    ..signal transduction is positively correlated to adiponectin, adenosine monophosphate-activated protein kinase (AMPK), and glucose-transporter-4 (GLUT4) but negatively to oxidative/inflammatory mediators such as nuclear factor-..
  85. pmc Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, 545 N Barnhill Drive, Indianapolis, IN 46202, USA
    Arch Biochem Biophys 485:10-5. 2009
    AMP-dependent protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR) alpha facilitate fatty acid oxidation...
  86. doi Muscle-specific differences in the response of mitochondrial proteins to beta-GPA feeding: an evaluation of potential mechanisms
    Deon B Williams
    Alberta Diabetes Institute, 4126C HRIF East, Univ of Alberta, Edmonton, Alberta, Canada T6G 2E1
    Am J Physiol Endocrinol Metab 296:E1400-8. 2009
    ..We hypothesized that beta-GPA feeding would result in a preferential activation of p38 MAPK and AMPK signaling and reductions in RIP140 protein content in triceps but not soleus muscle...
  87. pmc AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells
    Xiujuan Zhang
    Department of Endocrinology, Provincial Hospital affiliated to Shandong University, China
    J Cell Mol Med 13:758-70. 2009
    ..investigate effect of leucine on GSIS and its mechanism focusing on contribution of AMP-activated protein kinase (AMPK) and pancreatic/duodenal homeobox-1 (PDX-1)...
  88. doi AMP-activated protein kinase confers protection against TNF-{alpha}-induced cardiac cell death
    Girish Kewalramani
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Cardiovasc Res 84:42-53. 2009
    Although a substantial role for 5' adenosine monophosphate-activated protein kinase (AMPK) has been established in regulating cardiac metabolism, a less studied action of AMPK is its ability to prevent cardiac cell death...
  89. pmc AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons
    Beth Ann Murphy
    Dept of Pharmacology and Physiology, New Jersey Medical School, PO Box 1709, Newark, NJ 07101 1709, USA
    Am J Physiol Cell Physiol 297:C750-8. 2009
    ..We have previously shown that AMP-activated protein kinase (AMPK) increases nitric oxide (NO) production in VMH GI neurons...
  90. pmc Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes
    Dipanjan Chanda
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 284:28510-21. 2009
    ..and MSP on SHP gene expression was demonstrated to be mediated via activation of the AMP-activated protein kinase (AMPK) signaling pathway...
  91. pmc Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis
    Je Seong Won
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, SC 29425, USA
    Biochem Biophys Res Commun 399:487-91. 2010
    AMP-activated-protein-kinase (AMPK) is a key sensor and regulator of cellular and whole-body energy metabolism and plays a key role in regulation of lipid metabolism...
  92. pmc Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1
    Dong Fu
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA
    J Cell Sci 123:3294-302. 2010
    AMP-activated protein kinase (AMPK), a cellular metabolic sensor, is essential in energy regulation and metabolism. Hepatocyte polarization during liver development and regeneration parallels increased metabolism...
  93. doi Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase
    Charlotte J Green
    Division of Cell Signalling and Immunology, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 435:463-74. 2011
    ..Strikingly, both palmitate- and PMA-induced activation of IKK/NF-κB were antagonized by AMPK (AMP-activated protein kinase) activators because of reduced ERK signalling...
  94. ncbi Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca(2+)
    Edward O Ojuka
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 282:E1008-13. 2002
    ..5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR), which activates AMP-activated protein kinase (AMPK), also induced approximately twofold increases in GLUT4, MEF2A, and MEF2D in L6 myocytes...
  95. ncbi AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment
    Gregory R Steinberg
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 284:E648-54. 2003
    ..Acute stimulation of AMP-activated protein kinase (AMPK) results in a repartitioning of FA toward oxidation and away from esterification in rodent soleus muscle and has ..
  96. ncbi Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
    Xiangdong Wu
    Dorrance H Hamilton Research Laboratories, Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Jefferson Medical College of Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Diabetes 52:1355-63. 2003
    ....
  97. ncbi AMP-activated protein kinase plays a role in the control of food intake
    Ulrika Andersson
    Medical Research Council Clinical Sciences Centre, Cellular Stress Group and Endocrine Unit, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 279:12005-8. 2004
    AMP-activated protein kinase (AMPK) is the downstream component of a protein kinase cascade that acts as an intracellular energy sensor maintaining the energy balance within the cell...
  98. ncbi Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation
    David M Thomson
    Human Performance Laboratory, 363 Ward Sports Medicine Bldg, East Carolina Univ, Greenville, NC 27858, USA
    J Appl Physiol (1985) 98:557-64. 2005
    ..Because 5'-AMP-activated protein kinase (AMPK) activity is thought to inhibit skeletal muscle protein synthesis and may therefore modulate muscle mass and ..
  99. ncbi Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase
    D S Rubink
    Dept of Physiology and Developmental Biology, 545 WIDB, Brigham Young Univ, Provo, UT 84602, USA
    J Appl Physiol (1985) 98:1221-7. 2005
    AMP-activated protein kinase (AMPK) has previously been demonstrated to phosphorylate and inactivate skeletal muscle acetyl-CoA carboxylase (ACC), the enzyme responsible for synthesis of malonyl-CoA, an inhibitor of carnitine ..
  100. ncbi Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats
    Gabriela Suchankova
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Biochem Biophys Res Commun 326:851-8. 2005
    ..metformin, thiazolidinediones) and hormones (leptin, adiponectin) that activate AMP-activated protein kinase (AMPK) have been reported to improve insulin sensitivity...
  101. ncbi Hypoxia and AMP independently regulate AMP-activated protein kinase activity in heart
    Markus Frederich
    Nuclear Magnetic Resonance Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Heart Circ Physiol 288:H2412-21. 2005
    The hypothesis was tested that hypoxia increases AMP-activated protein kinase (AMPK) activity independently of AMP concentration ([AMP]) in heart. In isolated perfused rat hearts, cytosolic [AMP] was changed from 0...

Research Grants1

  1. VisualSonics Vevo 770 Imaging System
    Lawrence Young; Fiscal Year: 2007
    ..Adult cardiovascular disease is the leading cause of death in this country and congenital heart disease a major cause of disability and death in children. [unreadable] [unreadable] [unreadable]..