Alad

Summary

Gene Symbol: Alad
Description: aminolevulinate dehydratase
Alias: ALADR, aminolevulinatedelta-dehydratase, delta-aminolevulinic acid dehydratase, ALADH, aminolevulinate, delta-, dehydratase, delta - aminolevulinic acid dehydratase, porphobilinogen synthase
Species: rat

Top Publications

  1. pmc Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors
    Dulmini P Barupala
    Departments of Biochemistry and Molecular Biology, and Pharmaceutical Sciences, Wayne State University, Detroit, MI 48201, USA
    Arch Biochem Biophys 592:60-75. 2016
  2. ncbi Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase
    Guillermo O Noriega
    Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP, CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Free Radic Res 36:633-9. 2002
  3. ncbi Organic and inorganic forms of selenium inhibited differently fish (Rhamdia quelen) and rat (Rattus norvergicus albinus) delta-aminolevulinate dehydratase
    Félix Antunes Soares
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitario, Camobi, 97105 900 Santa Maria, RS, Brazil
    Environ Res 98:46-54. 2005
  4. ncbi Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats
    Geetu Saxena
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Pharm Pharmacol 58:547-59. 2006
  5. ncbi Regulation of porphyrin synthesis and photodynamic therapy in heavy metal intoxication
    Borislava Grinblat
    Faculty of Life Science, Bar Ilan University, Ramat Gan 52900 Israel
    J Environ Pathol Toxicol Oncol 25:145-58. 2006
  6. ncbi Biosynthesis of heme in mammals
    Richard S Ajioka
    Department of Internal Medicine, Division of Hematology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Biochim Biophys Acta 1763:723-36. 2006
  7. ncbi Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats
    S Bhadauria
    Defence Research and Development Establishment, Gwalior, India
    Cell Biol Toxicol 23:91-104. 2007
  8. ncbi Involvement of oxidative stress in seizures induced by diphenyl diselenide in rat pups
    Marina Prigol
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    Brain Res 1147:226-32. 2007
  9. ncbi Vitamin-E reduces the oxidative damage on delta-aminolevulinic dehydratase induced by lead intoxication in rat erythrocytes
    A Rendón-Ramirez
    Department of Biochemistry, CINVESTAV IPN, P O Box 14 740, Mexico City 07000, Mexico
    Toxicol In Vitro 21:1121-6. 2007
  10. ncbi Experimental hypothyroidism inhibits delta-aminolevulinate dehydratase activity in neonatal rat blood and liver
    Fernanda S Gravina
    Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035 003, Porto Alegre, RS, Brazil
    Exp Biol Med (Maywood) 232:1021-6. 2007

Scientific Experts

  • Swaran J S Flora
  • A Trevisan
  • Tatsuhiro Matsuo
  • N B V Barbosa
  • I J Kade
  • Cristina W Nogueira
  • Joao B T Rocha
  • Ethel A Wilhelm
  • Marina Prigol
  • Dulmini P Barupala
  • Guillermo O Noriega
  • Pratibha Gautam
  • Juliana Valentini
  • Itala Mônica de Sales Santos
  • M G K Callegaro
  • Mohammad Ibrahim
  • José S Casas
  • Swapnila Chouhan
  • G Sharmila Banu
  • Cristiane L Dalla Corte
  • T Emanuelli
  • Fredi Cifuentes
  • Nan Li
  • Roselei Fachinetto
  • Caroline Wagner
  • P R Augusti
  • D Mishra
  • Daiana Silva Avila
  • S Bhadauria
  • A Rendón-Ramirez
  • Fernanda S Gravina
  • Tsuyoshi Tahara
  • Vijayta Dani
  • Borislava Grinblat
  • Richard S Ajioka
  • Geetu Saxena
  • Marcelo Farina
  • Félix Antunes Soares
  • Timothy L Stemmler
  • PAMELA JO RIGGS-GELASCO
  • Stephen P Dzul
  • Joyceline Kaganda
  • Maria L Tomaro
  • Hyung Sook Kang
  • B K Lee
  • V L Dressler
  • Eduardo E Castellano
  • E M M Flores
  • M Dolores Torres
  • M Félix Camiña
  • Vinay Lomash
  • F A Duarte
  • Angeles Gato
  • Waseem Hassan
  • Agustin Sanchez
  • B G Milbradt
  • Chistiane Mendes Feitosa
  • Dejiang Feng
  • Fernando Barbosa
  • Geane Felix de Souza
  • L P Silva
  • Denise Grotto
  • E Alves
  • José Sordo
  • T Diettrich
  • Juliana Vicentini
  • Raquel Tonello
  • Joaquin Jordan
  • Carmen Alvarez-Lorenzo
  • María D Couce
  • Solange C Garcia
  • Rivelilson Mendes de Freitas
  • M Victoria Castaño
  • Adriana da Rocha Tomé
  • Milton Norambuena
  • Robson Puntel
  • Xiusheng Chu
  • Javier Palacios
  • Lucielli Savegnago
  • A G Murugesan
  • Susana Stegen
  • Silvane Souza Roman
  • G Kumar
  • Alejandra Ayavire
  • Félix A Antunes Soares
  • Xiaojun Liu
  • Cristiano R Jesse
  • Ding Li
  • Jaime Bravo
  • M P Rocha

Detail Information

Publications56

  1. pmc Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors
    Dulmini P Barupala
    Departments of Biochemistry and Molecular Biology, and Pharmaceutical Sciences, Wayne State University, Detroit, MI 48201, USA
    Arch Biochem Biophys 592:60-75. 2016
    ....
  2. ncbi Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase
    Guillermo O Noriega
    Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP, CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Free Radic Res 36:633-9. 2002
    ..This study shows that oxidative stress produced by paraquat leads to an increase in delta-aminolevulinic acid synthase and heme oxygenase-1 activities, indicating that the herbicide affects both heme biosynthesis and degradation...
  3. ncbi Organic and inorganic forms of selenium inhibited differently fish (Rhamdia quelen) and rat (Rattus norvergicus albinus) delta-aminolevulinate dehydratase
    Félix Antunes Soares
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Campus Universitario, Camobi, 97105 900 Santa Maria, RS, Brazil
    Environ Res 98:46-54. 2005
    ..From an ecotoxicological point of view, our results suggest a link between selenium-induced anemia signs in fish and the sensitivity of fish delta-ALA-D to selenium in natural habitats...
  4. ncbi Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats
    Geetu Saxena
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Pharm Pharmacol 58:547-59. 2006
    ..Lead exposure caused a significant depletion of blood and brain delta-aminolevulinic acid dehydratase (ALAD) activity, an important enzyme of the haem biosynthesis pathway, and glutathione (GSH) level...
  5. ncbi Regulation of porphyrin synthesis and photodynamic therapy in heavy metal intoxication
    Borislava Grinblat
    Faculty of Life Science, Bar Ilan University, Ramat Gan 52900 Israel
    J Environ Pathol Toxicol Oncol 25:145-58. 2006
    ..The heavy metal intoxication affected two of the heme-synthesis enzymes, ALA-dehydratase (ALAD) and porphobilinogen deaminase (PBGD)...
  6. ncbi Biosynthesis of heme in mammals
    Richard S Ajioka
    Department of Internal Medicine, Division of Hematology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Biochim Biophys Acta 1763:723-36. 2006
    ..The biochemistry, structural biology and the mechanisms of tissue-specific regulation are presented in this review along with the key features of the porphyric disorders...
  7. ncbi Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats
    S Bhadauria
    Defence Research and Development Establishment, Gwalior, India
    Cell Biol Toxicol 23:91-104. 2007
    ..Arsenic exposure led to the inhibition of blood delta-aminolevulinic acid dehydratase (ALAD) activity and depletion of glutathione (GSH) level...
  8. ncbi Involvement of oxidative stress in seizures induced by diphenyl diselenide in rat pups
    Marina Prigol
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105 900, RS, Brazil
    Brain Res 1147:226-32. 2007
    ..Taken together, this paper could add to our understanding of diphenyl diselenide neurotoxic effect demonstrated by the appearance of seizures which are, at least in part, related to the oxidative stress...
  9. ncbi Vitamin-E reduces the oxidative damage on delta-aminolevulinic dehydratase induced by lead intoxication in rat erythrocytes
    A Rendón-Ramirez
    Department of Biochemistry, CINVESTAV IPN, P O Box 14 740, Mexico City 07000, Mexico
    Toxicol In Vitro 21:1121-6. 2007
    ..These results indicate that vitamin-E could be useful in order to protect membrane-lipids and, notably, to prevent protein oxidation produced by lead intoxication...
  10. ncbi Experimental hypothyroidism inhibits delta-aminolevulinate dehydratase activity in neonatal rat blood and liver
    Fernanda S Gravina
    Departamento de Bioquimica, Rua Ramiro Barcelos 2600 anexo, Universidade Federal do Rio Grande do Sul, 90035 003, Porto Alegre, RS, Brazil
    Exp Biol Med (Maywood) 232:1021-6. 2007
    ..These results are the first to show a correlation between hypothyroidism and decreased delta-ALA-D activity and point to this enzyme as a potential molecule involved with hypothyroidism-related hematological changes...
  11. ncbi Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats
    P R Augusti
    Post graduate Program on Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, 97105 900 Santa Maria, RS, Brazil
    Food Chem Toxicol 46:212-9. 2008
    ..Our results indicate that ASX could have a beneficial role against HgCl(2) toxicity by preventing lipid and protein oxidation, changes in the activity of antioxidant enzymes and histopathological changes...
  12. ncbi 131I induced hematological alterations in rat blood: protection by zinc
    Vijayta Dani
    Department of Biophysics, Panjab University, Chandigarh 160014, India
    Biol Trace Elem Res 120:219-26. 2007
    ..hematocrit, zinc protoporphyrins (ZPP), activities of enzymes which included aminolevulinic acid dehydratase (delta-ALAD) and Na+ K+ ATPase and uptake of 65Zn in blood...
  13. doi Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats
    I J Kade
    Postgraduate Programme in Biochemical Toxicology, Centre for Natural and Exact Sciences, Federal University of Santa Maria, CEP 97105 900, Camobi, Santa Maria RS, Brazil
    Cell Biol Toxicol 25:415-24. 2009
    ..Finally, the inhibition of catalase, delta aminolevulinic acid dehydratase (eth-ALA-D) and isoforms of lactate dehydrogenase (LDH) accompanied by hyperglycemia were ..
  14. doi Differential oxidative stress and DNA damage in rat brain regions and blood following chronic arsenic exposure
    D Mishra
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Toxicol Ind Health 24:247-56. 2008
    ..The present study, thus, leads us to suggest that arsenic induces differential oxidative stress in brain regions with cortex followed by hippocampus and causes single-strand DNA damage in lymphocytes...
  15. doi Probing the active site of rat porphobilinogen synthase using newly developed inhibitors
    Nan Li
    Department of Biology and Chemistry, City University of Hong Kong, Kowloon, SAR, PR China
    Bioorg Chem 37:33-40. 2009
    ..b>Porphobilinogen synthase catalyzes a rate-limiting step for the biosyntheses of tetrapyrrolic natural products...
  16. doi Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide
    Ethel A Wilhelm
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, RS, Brazil
    Exp Mol Pathol 87:20-6. 2009
    ..Compound a attenuated D-GalN/LPS-induced hepatic histopathological alterations. Based on the results, we demonstrated the hepatoprotective effect of compound a on acute liver injury induced by D-GalN/LPS...
  17. doi Chronic treatment with fluphenazine alters parameters of oxidative stress in liver and kidney of rats
    Cristiane L Dalla Corte
    Federal University of Santa Maria, Center of Exacts and Natural Sciences, Chemistry Department, Graduation Program of Toxicological Biochemistry, Santa Maria, RS, Brazil
    Basic Clin Pharmacol Toxicol 105:51-7. 2009
    ..Moreover, our data point to the relationship between the oxidative stress and fluphenazine treatment in liver and kidney of rats...
  18. doi Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats
    Pratibha Gautam
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Nutrition 26:563-70. 2010
    ..The objective was to study the efficacy of oral supplementation of gossypin, a flavonoid, during lead exposure in preventive alterations in the heme synthesis pathway, brain oxidation, and tissue lead uptake in rats...
  19. doi Sub-chronic exposure to methylmercury at low levels decreases butyrylcholinesterase activity in rats
    Juliana Valentini
    Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    Basic Clin Pharmacol Toxicol 106:95-9. 2010
    ..This preliminary finding highlights a possible mechanism for MeHg to reduce BuChE activity in plasma. Additionally, this enzyme could be an auxiliary biomarker on the evaluation of MeHg exposure...
  20. doi Chronic exposure to arsenic in tap water reduces acetylcholine-induced relaxation in the aorta and increases oxidative stress in female rats
    Fredi Cifuentes
    Departamento de Químicas y Farmacia, Facultad de Ciencias, Universidad Catolica del Norte, Angamos 0610 Antofagasta, Chile
    Int J Toxicol 28:534-41. 2009
    ..The results indicate that chronic environmental exposure to low levels of arsenic alters the release of vasoactive substances, causes changes in oxidative stress, and increases blood pressure in female rats...
  21. doi Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain
    Itala Mônica de Sales Santos
    Laboratory of Experimental Research in Biological Sciences of Federal University of Piauí, Piaui, Brazil
    Pharmacol Biochem Behav 95:88-91. 2010
    ..The results from the present study demonstrate that preadministration of LA abolished seizure episodes induced by pilocarpine in rat, probably by increasing delta-ALA-D and Na(+), K(+)-ATPase activities in rat brain during seizures...
  22. doi Interactions of diorganolead(IV) with 3-(2-thienyl)-2-sulfanylpropenoic acid and/or thiamine: chemical and in vitro and in vivo toxicological results
    José S Casas
    Departamento de Quimica Inorganica, Facultade de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain
    Inorg Chem 49:2173-81. 2010
    ..Sprague-Dawley rats dosed 30 min previously with PbMe(2)(NO(3))(2) was associated with reduced inhibition of delta-ALAD by the organolead compound, and with lower lead levels in kidney and brain, but joint administration of both H(2)..
  23. doi Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2-nitropropane-induced hepatotoxicity in rats
    Mohammad Ibrahim
    Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Cell Biochem Funct 28:258-65. 2010
    ..Results presented here indicate that the protective mechanism of (NapSe)(2) against 2-NP hepatotoxicity is possibly linked to its antioxidant activity...
  24. pmc Evidence for the catabolism of polychlorinated biphenyl-induced cytochrome P-448 by microsomal heme oxygenase, and the inhibition of delta-aminolevulinate dehydratase by polychlorinated biphenyls
    M D Maines
    J Exp Med 144:1509-19. 1976
    ..PCB were also found to decrease the activity of delta-aminolevulinic acid dehydratase (ALAD) in liver...
  25. ncbi Development of iron deficiency decreases zinc requirement of rats
    Joyceline Kaganda
    Department of Biochemistry and Food Science, Faculty of Agriculture, Kagawa University, Ikenobe, Miki cho, Kita gun, Kagawa 761 0795, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:234-40. 2003
    ..The decrease in apparent Zn absorption and the increase in tissue Zn concentration of rats might be related to the lowered Zn requirement, which is associated with the depressed Zn metabolism caused by feeding Fe-deficient diets...
  26. ncbi Influence of protein calorie malnutrition and fasting on the activities of delta-aminolevulinic acid dehydratase and porphobilinogen deaminase in rats
    D G Adjarov
    Centre of Hygiene, Ecology and Nutrition, Sofia, Bulgaria
    Exp Toxicol Pathol 46:199-202. 1994
    ..The erythrocyte activity of porphobilinogen deaminase was reduced by 42% and its hepatic activity--by 16%...
  27. ncbi Effect of homeopathic drugs plumbum and opium on experimentally induced lead toxicity in rats
    R Begum
    Department of Biochemistry, Faculty of Science, M S University of Baroda, India
    Indian J Exp Biol 32:192-5. 1994
    Homeopathic drugs plumbum 1M and Opium 30 were partially effective in the recovery of delta ALAD activity of the lead (150 mg% lead acetate) intoxicated rats...
  28. pmc Isolation of a rat liver delta-aminolevulinate dehydrase (ALAD) cDNA clone: evidence for unequal ALAD gene dosage among inbred mouse strains
    T R Bishop
    Proc Natl Acad Sci U S A 83:5568-72. 1986
    We have isolated several cDNA clones encoding delta-aminolevulinate dehydrase [ALAD; porphobilinogen synthase; 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1...
  29. ncbi delta-Aminolevulinic acid dehydratase in rat liver: studies on the effects of ethanol, acetaldehyde, and B6 vitamers
    L R Solomon
    Department of Medicine, Veterans Administration Medical Center, West Haven, Connecticut
    J Lab Clin Med 116:228-36. 1990
    Because ethanol ingestion lowers delta-aminolevulinic acid dehydratase (ALAD) activity in liver and red cells, effects of ethanol and acetaldehyde on ALAD in rat liver cytosol were studied. When added to the assay mix, as little as 0...
  30. ncbi Message amplification phenotyping of an inherited delta-aminolevulinate dehydratase deficiency in a family with acute hepatic porphyria
    N Ishida
    Rockefeller University Hospital, New York, N Y 10021
    Biochem Biophys Res Commun 172:237-42. 1990
    ..basis of the enzymatic defect responsible for acute hepatic porphyria due to delta-aminolevulinate dehydratase (ALAD) deficiency was investigated in a family including a proband with the acute disease...
  31. pmc Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes
    B K Lee
    Institute of Industrial Medicine, Soonchunhyang University, Chonan, Korea
    Environ Health Perspect 109:383-9. 2001
    ..toxicokinetics of lead--namely, those for the vitamin D receptor (VDR) and delta-aminolevulinic acid dehydratase (ALAD)--may independently influence blood pressure and hypertension risk...
  32. ncbi Voluntary resistance exercise improves blood hemoglobin concentration in severely iron-deficient rats
    Tatsuhiro Matsuo
    Faculty of Agriculture, Kagawa University, Ikenobe, Kitagun, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:161-4. 2002
    ..Resistance exercise may be a useful therapy for iron-deficient anemia...
  33. ncbi Renal heme metabolism in hereditary tyrosinemia: use of succinylacetone in rat renal tubules
    P A Wyss
    Department of Medicine, Medical College of Virginia, Richmond 23298
    Biochim Biophys Acta 1070:300-4. 1991
    ..and associated renal Fanconi syndrome and a known inhibitor of hepatic 5-aminolevulinic acid dehydratase (ALAD), has been used to study heme metabolism in isolated rat renal tubules...
  34. ncbi Bilirubin is highly effective in preventing in vivo delta-aminolevulinic acid-induced oxidative cell damage
    Guillermo O Noriega
    Centro de Investigaciones sobre Porfirinas y Porfirias CIPYP, CONICET Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Biochim Biophys Acta 1638:173-8. 2003
    ..These results add further support to the proposal assigning bilirubin a key protective role against oxidative damage here induced by ALA...
  35. doi Influence of cereal bran supplement on cadmium effects in growing rats
    M G K Callegaro
    Graduate Program in Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil
    Hum Exp Toxicol 29:467-76. 2010
    ..Although this multimixture was ineffective to prevent Cd effects at the higher concentration, it seemed to reduce Cd accumulation at the lower Cd dietary concentration, which is similar to levels of human exposure in some polluted areas...
  36. doi Fluoride-induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats
    Swapnila Chouhan
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Appl Toxicol 30:63-73. 2010
    ..These changes support our earlier findings regarding the role of decreased ionic mobility of fluoride ion at higher concentrations, leading to less pronounced toxicity...
  37. pmc Nucleotide sequence of rat liver delta-aminolevulinic acid dehydratase cDNA
    T R Bishop
    Nucleic Acids Res 14:10115. 1986
  38. ncbi Aminolevulinic acid dehydratase activity in the blood of rats exposed to tin and zinc
    G Zareba
    Ecotoxicol Environ Saf 9:40-6. 1985
    ..Control animals received 0.9% NaCl. Aminolevulinic acid dehydratase (ALAD) activity was clearly decreased due to the double tin dose (total dose 4 mg Sn/kg), whereas 7 doses (altogether 14 ..
  39. doi Effects of leaves extract of Ocimum sanctum L. on arsenic-induced toxicity in Wistar albino rats
    G Sharmila Banu
    Centre for Biotechnology, Muthayammal College of Arts and Sciences, Kakkaveri, Rasipuram, Namakkal 637408, Tamilnadu, India
    Food Chem Toxicol 47:490-5. 2009
    ..Animals exposed to arsenic (III) showed a significant inhibition of delta-aminolevulinic acid dehydratase (ALAD) activity, decrease in reduced glutathione (GSH) level and an increase in reactive oxygen species (ROS) in blood...
  40. ncbi Acute diphenyl diselenide treatment reduces hyperglycemia but does not change delta-aminolevulinate dehydratase activity in alloxan-induced diabetes in rats
    Nilda Berenice de Vargas Barbosa
    Centro de Ciencias da Saude, Fundação Universidade Federal do Pampa, Uruguaiana, CEP 97500 970, RS, Brasil
    Biol Pharm Bull 31:2200-4. 2008
    ..Although the dose of diphenyl diselenide used here for treating diabetic animals has been relatively high and produced toxic effects, the compound or analogous molecules might not be rejected as a promising anti-hyperglycemic agent...
  41. doi Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese
    Daiana Silva Avila
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, CEP 97105 900 Santa Maria, RS, Brazil
    Neurotoxicology 29:1062-8. 2008
    ..In conclusion, Mn caused increased oxidative stress and decreased (45)Ca(2+) influx into the striatum, which are likely linked to impaired locomotor activity, but not with the occurrence of orofacial dyskinesia...
  42. ncbi Effect of simultaneous low level exposure of Pb and Cd on delta-ALAD and acetylcholinesterase activity in rats
    S Gupta
    Department of Biochemistry, Faculty of Science, M S University of Baroda, India
    Indian J Exp Biol 32:819-21. 1994
    Dose dependent study was performed to identify subcritical level of Pb and Cd. Blood delta-ALAD activity was inhibited by (0...
  43. ncbi Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects
    S J S Flora
    Department of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Biol Trace Elem Res 120:235-47. 2007
    ..Apart from this it also significantly reduced the glutathione disulfide levels in tissues. However, administration of MiADMSA caused some concern over the copper loss. MiADMSA was found to be safe in rats of all ages...
  44. ncbi Effect of zinc or S-adenosyl-l-methionine on long term administration of low doses of lead to rats
    J J Munoz
    Porphyria Research Unit, University Hospital Doce de Octubre, Madrid, Spain
    Pharmacol Toxicol 73:189-91. 1993
    ..01) higher activities of the enzyme. It is argued that SAM treatment causes a surplus of thiols that allows the full expression of ALA-D catalytic activity...
  45. ncbi In vivo protection by melatonin against delta-aminolevulinic acid-induced oxidative damage and its antioxidant effect on the activity of haem enzymes
    F G Princ
    Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    J Pineal Res 24:1-8. 1998
    ..The potential use of melatonin as an antioxidant and for its reactivating properties in the treatment of acute porphyrias is considered...
  46. ncbi Lead induced disorders in hematopoietic and drug metabolizing enzyme system and their protection by ascorbic acid supplementation
    A G Vij
    Defence Institute of Physiology and Allied Sciences, Timarpur, Delhi, India
    Biomed Environ Sci 11:7-14. 1998
    ..Oral supplementation of vitamin C (100 mg/kg for 3 days) completely restored blood delta aminolevulinic acid dehydratase, uroporphyrinogen I synthetase and a few drug metabolizing enzymes...
  47. ncbi Decrease of hepatic delta-aminolevulinate dehydratase activity in an animal model of fatigue
    Tsuyoshi Tahara
    Department of Physiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 353:1068-73. 2007
    ..We also examined the activity of the enzyme ALA dehydratase (ALAD), which is the second enzyme in the heme biosynthetic pathway, and ALAD gene expression during the fatigue and its ..
  48. ncbi Effects of voluntary resistance exercise on heme biosynthesis in rats given glucocorticoid-injections
    Hyung Sook Kang
    Graduate School of East West Medical Science, Kyung Hee University, Seoul, Korea
    Biosci Biotechnol Biochem 66:2710-4. 2002
    ..Resistance exercise may be a preventive therapy for iron-deficiency anemia associated with aging...
  49. ncbi Erythrocyte aminolevulinic acid dehydratase inhibition by cis-platin
    Andrea Trevisan
    Department of Environmental Medicine and Public Health, University of Padua, Via Giustiniani 2, I 35128 Padua, Italy
    Toxicol Lett 152:105-10. 2004
    The effect of cis-platin on erythrocyte aminolevulinic acid dehydratase (ALAD) activity was studied in vivo and in vitro. Young male Wistar rats were treated with a single i.p. injection of cis-platin at 2.5, 5.0, and 10.0mg/kg dose...