Adm2

Summary

Gene Symbol: Adm2
Description: adrenomedullin 2
Alias: Imd, ADM2, intermedin
Species: rat

Top Publications

  1. doi Adrenomedullin 2/intermedin-like immunoreactivity in the hypothalamus and brainstem of rats
    Hirofumi Hashimoto
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Auton Neurosci 139:46-54. 2008
  2. pmc Potential role of intermedin/adrenomedullin 2 in early embryonic development in rats
    Madhu Chauhan
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Regul Pept 170:65-71. 2011
  3. pmc Regulation of oocyte and cumulus cell interactions by intermedin/adrenomedullin 2
    Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung University School of Medicine, Chang Gung Memorial Hospital Linkou Medical Center, Kweishan, Taoyuan 333, Taiwan
    J Biol Chem 286:43193-203. 2011
  4. doi Extracellular signal-regulated kinase 1/2 activation is involved in intermedin1-53 attenuating myocardial oxidative stress injury induced by ischemia/reperfusion
    Lei Zhao
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
    Peptides 33:329-35. 2012
  5. doi Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats
    Qiang Zeng
    Second Department of Geriatrics Cardiology, Chinese PLA General Hospital, Beijing 100853, China
    Peptides 30:391-9. 2009
  6. pmc Intermedin ameliorates vascular and renal injury by inhibition of oxidative stress
    Makoto Hagiwara
    Dept of Biochemistry and Molecular Biology, Medical Univ of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 295:F1735-43. 2008
  7. doi Adrenomedullin 2 microinjection into the nucleus tractus solitarius elevates arterial pressure and heart rate in rats
    He Cui
    Department of Physiology, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama City, Wakayama 641 8509, Japan
    Auton Neurosci 142:45-50. 2008
  8. doi Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats
    Ye Bo Zhou
    Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, 140 Hanzhong Rd, Nanjing 210029, China
    Hypertension 63:330-7. 2014
  9. ncbi Roles of adrenomedullin 2 in regulating the cardiovascular and sympathetic nervous systems in conscious rats
    Yoshihide Fujisawa
    Research Equipment Center, School of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Am J Physiol Heart Circ Physiol 290:H1120-7. 2006
  10. ncbi Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 279:7264-74. 2004

Scientific Experts

  • Madhu Chauhan
  • Chia Lin Chang
  • Muhammad Aslam
  • Meghan M Taylor
  • Yoshio Takei
  • Katsuyuki Miura
  • Guo Qing Zhu
  • Ali Akbar Owji
  • Chao Shu Tang
  • Yong Fen Qi
  • Ye Bo Zhou
  • Jing Hui Yang
  • Yong sheng Gong
  • Yan Cai
  • Takuo Hirose
  • Hai Jian Sun
  • Hong Zhou
  • Yan Rong Yu
  • Chun Shui Pan
  • Jin Rui Chang
  • Xiao Fang Fan
  • Lei Zhao
  • Xu Teng
  • Kazuhiro Takahashi
  • Liang Gang Hu
  • Qingtao Meng
  • Jing Zhao
  • Yong Zheng Pang
  • Xi Qiao
  • Wei wei Lu
  • Dan Chen
  • Xian bing Gan
  • Shuji Nagasaki
  • Lei Li
  • Ana Luisa Pires
  • Chi Wai Wong
  • X Teng
  • Fai Tang
  • Wai sum O
  • Xiaoping Chen
  • Jaesook Roh
  • Yi Zhu
  • Hironobu Sasano
  • Gerald Münzel
  • Nobuyoshi Mori
  • Qiang Zeng
  • Masahiro Kohzuki
  • L Jolly
  • Kazuhito Totsune
  • Yutaka Imai
  • Masahiro Kikuya
  • Hirohito Metoki
  • Jing Zhang
  • Kei Asayama
  • Ryo Morimoto
  • Takayoshi Ohkubo
  • Jing Dong
  • Makoto Hagiwara
  • Ping Huang
  • Hirofumi Hashimoto
  • He Cui
  • Xiao Mai Wu
  • Yoshihide Fujisawa
  • H Burak Kandilci
  • Yue Xia Jia
  • Jun Yang
  • Chia Lin Chang
  • Sheau Yu Teddy Hsu
  • Cynthia Klein
  • Yanling Su
  • Sen He
  • Yong Wang
  • Si Wang
  • Di Shi
  • Xiangxun Zhang
  • Yang Long
  • Jiayue Feng
  • Zhiqiang Peng
  • Jin Sheng Zhang
  • Lihua Wang
  • Ruijing Zhang
  • Ning Zhao
  • Mo Zhi Jia
  • Yanhong Wang
  • Yue Long Hou
  • Weixia Han
  • Ying Han
  • Li Yan Chen
  • Ling Li Zhang
  • Katsuhiko Ono

Detail Information

Publications42

  1. doi Adrenomedullin 2/intermedin-like immunoreactivity in the hypothalamus and brainstem of rats
    Hirofumi Hashimoto
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Auton Neurosci 139:46-54. 2008
    Adrenomedullin 2 (AM2) (identical to intermedin)-like immunoreactivity (LI) was examined in the rat brain by immunohistochemistry after intracerebroventricular administration of colchicine (100 microg/rat) and chronic salt loading (2% ..
  2. pmc Potential role of intermedin/adrenomedullin 2 in early embryonic development in rats
    Madhu Chauhan
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA
    Regul Pept 170:65-71. 2011
    Adrenomedullin2 (ADM2), also referred to as Intermedin (IMD) is expressed in trophoblast cells in human placenta and enhances the invasion and migration of first trimester HTR-8/SV-neo cells...
  3. pmc Regulation of oocyte and cumulus cell interactions by intermedin/adrenomedullin 2
    Chia Lin Chang
    Department of Obstetrics and Gynecology, Chang Gung University School of Medicine, Chang Gung Memorial Hospital Linkou Medical Center, Kweishan, Taoyuan 333, Taiwan
    J Biol Chem 286:43193-203. 2011
    ..Based on genomic screening and studies of COCs cultured in vitro, we showed that intermedin (IMD)/adrenomedullin 2 (ADM2) is a novel oocyte-derived ligand important for the regulation of cell interactions ..
  4. doi Extracellular signal-regulated kinase 1/2 activation is involved in intermedin1-53 attenuating myocardial oxidative stress injury induced by ischemia/reperfusion
    Lei Zhao
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100191, China
    Peptides 33:329-35. 2012
    b>Intermedin (IMD)(1-53) is a novel member of the calcitonin gene-related peptide superfamily and has potent cardioprotective effects against myocardial injury induced by ischemia-reperfusion (I/R)...
  5. doi Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats
    Qiang Zeng
    Second Department of Geriatrics Cardiology, Chinese PLA General Hospital, Beijing 100853, China
    Peptides 30:391-9. 2009
    b>Intermedin (IMD), also called adrenomedullin 2 (ADM2), is a 47-amino acid peptide belonging to the calcitonin/calcitonin gene-related peptide (CGRP) family...
  6. pmc Intermedin ameliorates vascular and renal injury by inhibition of oxidative stress
    Makoto Hagiwara
    Dept of Biochemistry and Molecular Biology, Medical Univ of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 295:F1735-43. 2008
    b>Intermedin (IMD) is a newly discovered peptide related to calcitonin gene-related peptide and adrenomedullin, and has been shown to reduce blood pressure and reactive oxygen species formation in vivo...
  7. doi Adrenomedullin 2 microinjection into the nucleus tractus solitarius elevates arterial pressure and heart rate in rats
    He Cui
    Department of Physiology, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama City, Wakayama 641 8509, Japan
    Auton Neurosci 142:45-50. 2008
    ..Our results indicate that AM2 may play an important role in the regulation of the cardiovascular system at the NTS level...
  8. doi Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats
    Ye Bo Zhou
    Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, 140 Hanzhong Rd, Nanjing 210029, China
    Hypertension 63:330-7. 2014
    b>Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide family, which shares the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying proteins (RAMPs)...
  9. ncbi Roles of adrenomedullin 2 in regulating the cardiovascular and sympathetic nervous systems in conscious rats
    Yoshihide Fujisawa
    Research Equipment Center, School of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Am J Physiol Heart Circ Physiol 290:H1120-7. 2006
    Recently, a new member of the calcitonin gene-related peptide (CGRP) family, adrenomedullin 2 (AM2) or intermedin (IMD), was identified...
  10. ncbi Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    Jaesook Roh
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    J Biol Chem 279:7264-74. 2004
    ..Based on phylogenetic analysis, we identified intermedin as a novel member of the calcitonin/CGRP peptide family...
  11. ncbi Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator
    Yoshio Takei
    Laboratory of Physiology, Department of Marine Bioscience, Ocean Research Institute, University of Tokyo, 1 15 1 Minamidai, Nakano Ku, 164 8639, Tokyo, Japan
    FEBS Lett 556:53-8. 2004
    ..These results show that at least two peptides, AM and AM2, comprise an adrenomedullin family in mammals, and that AM2 may play pivotal roles in cardiovascular and body fluid regulation...
  12. doi Cardiac sympathetic afferent reflex response to intermedin microinjection into paraventricular nucleus is mediated by nitric oxide and γ-amino butyric acid in hypertensive rats
    Hong Zhou
    Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing 210029, China Laboratory Center for Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China
    Exp Biol Med (Maywood) 239:1352-9. 2014
    b>Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide (CGRP) and involves in the regulation of cardiovascular function in both peripheral tissues and central nervous system (CNS)...
  13. pmc Intermedin in the paraventricular nucleus attenuates cardiac sympathetic afferent reflex in chronic heart failure rats
    Xian bing Gan
    Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, China Department of Physiology, Anhui University of Chinese Medicine, Hefei, China
    PLoS ONE 9:e94234. 2014
    b>Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide (CGRP) family together with adrenomedullin (AM) and amylin...
  14. ncbi Hypercholesterolemia Up-Regulates the Expression of Intermedin and Its Receptor Components in the Aorta of Rats via Inducing the Oxidative Stress
    Qingtao Meng
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
    Ann Clin Lab Sci 46:5-17. 2016
    Hypercholesterolemia can cause damage to the artery. Intermedin (IMD) is a novel member of the calcitonin gene-related peptide family...
  15. doi Induction of adrenomedullin 2/intermedin expression by thyroid stimulating hormone in thyroid
    Shuji Nagasaki
    Drug Discovery Department, ASKA Pharmaceutical Co, Ltd, Kawasaki, Japan Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan Electronic address
    Mol Cell Endocrinol 395:32-40. 2014
    ..The result of microarray analysis demonstrated markedly increased levels of adrenomedullin 2/intermedin (AM2/IMD) expression in the ID rat thyroid. AM2/IMD is a potent vasodilator...
  16. pmc Adrenomedullin2 (ADM2)/intermedin (IMD) in rat ovary: changes in estrous cycle and pregnancy and its role in ovulation and steroidogenesis
    Madhu Chauhan
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas
    Biol Reprod 92:39. 2015
    Adrenomedullin2 (ADM2) is reported to facilitate embryo implantation and placental development. Therefore, the current study was undertaken to identify if ADM2 has a functional role in ovary to facilitate its reproductive actions...
  17. doi Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction
    Xi Qiao
    Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
    Nephrology (Carlton) 20:820-31. 2015
    ..Reactive oxygen species mediate profibrotic action of TGF-β1. Intermedin (IMD) has been shown to inhibit oxidative stress, but its role in renal fibrosis remains unclear...
  18. pmc Intermedin attenuates LPS-induced inflammation in the rat testis
    Lei Li
    Research Center for Gene and Cell Engineering, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advance Technology, Chinese Academy of Sciences, Shenzhen City, China
    PLoS ONE 8:e65278. 2013
    First reported as a vasoactive peptide in the cardiovascular system, intermedin (IMD), also known as adrenomedullin 2 (ADM2), is a hormone with multiple potent roles, including its antioxidant action on the pulmonary, central nervous, ..
  19. doi Intermedin1-53 protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase
    Wei wei Lu
    aLaboratory of Cardiovascular Bioactive Molecule, School of Basic Medical Sciences, Peking University bKey Laboratory of Molecular Cardiovascular Science, Ministry of Education cDepartment of Pathogen Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    J Hypertens 33:1676-87. 2015
    b>Intermedin (IMD), a novel member of the calcitonin/calcitonin gene-related peptide family, is involved in maintaining circulatory homeostasis and is a protective factor of heart and vessel...
  20. pmc Intermedin in rat uterus: changes in gene expression and peptide levels across the estrous cycle and its effects on uterine contraction
    Chi Wai Wong
    Departments of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Reprod Biol Endocrinol 11:13. 2013
    The present study demonstrates the expression of intermedin (IMD) and its receptor components in the uterus of the female rat during the estrous cycle and its effect on uterine contraction.
  21. doi Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway
    Jin Rui Chang
    Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University Health Science Center, Beijing 100191, China
    Exp Biol Med (Maywood) 238:1136-46. 2013
    ..In conclusion, IMD1-53 attenuated VSMC calcification by inhibiting ER stress through cAMP/PKA signalling...
  22. ncbi [Changes of adrenomedullin 2/intermedin in the lung of rats with chronic hypoxic pulmonary hypertension]
    Xiao Fang Fan
    Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou 325035, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 23:467-71. 2007
    To investigate the changes and probable roles of adrenomedullin2/intermedin (AIDM2/IMD), a novel micromolecular bioactive peptide, in the lungs of rats with chronic hypoxic pulmonary hypertension.
  23. ncbi [Effect of hypoxia on the expressions of intermedin/ adrenomedullin2 in plasma and the tissues of heart and lung in rats]
    Yong sheng Gong
    Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou 325035, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 25:8-11. 2009
    To study the effect and significances of two-week hypoxia on the expression of intermedin/adrenomedullin2 (IMD/ADM2) in plasma and the tissues of heart and lung in rats.
  24. doi Intermedin induces loss of coronary microvascular endothelial barrier via derangement of actin cytoskeleton: role of RhoA and Rac1
    Muhammad Aslam
    Physiologisches Institut, Justus Liebig Universitat, Aulweg 129, D 35392 Giessen, Germany
    Cardiovasc Res 92:276-86. 2011
    b>Intermedin (IMD) is a novel member of the calcitonin gene-related peptide family, which acts via calcitonin receptor-like receptors (CLRs), mediating activation of cAMP signalling...
  25. doi Rat intermedin1-47 does not improve functional recovery in postischemic hearts
    Gerald Münzel
    Physiologisches Institut, Justus Liebig Universitat, Aulweg 149, 35392, Giessen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 384:535-42. 2011
    b>Intermedin, a novel member of the calcitonin/calcitonin gene-related peptide family identified from vertebrate genomes, may directly affect cardiac function but current studies revealed no clear picture...
  26. doi Downregulation of endogenous intermedin augmented myocardial injury in rats with ischemia/reperfusion
    X Teng
    The Key Laboratory of Remodeling related Cardiovascular Diseases, Capital Medical University, Ministry of Education, Beijing, China
    Horm Metab Res 45:206-12. 2013
    b>Intermedin (IMD) plays an important regulatory role in cardiovascular function...
  27. pmc Reverse myocardial effects of intermedin in pressure-overloaded hearts: role of endothelial nitric oxide synthase activity
    Ana Luisa Pires
    Department of Physiology and Cardiothoracic Surgery, Cardiovascular R and D Unit, Faculty of Medicine, University of Porto, Portugal
    J Physiol 591:677-87. 2013
    b>Intermedin (IMD) is a cardiac peptide synthesized in a prepro form, which undergoes a series of proteolytic cleavages and amidations to yield the active forms of 47 (IMD(1-47)) and 40 amino acids (IMD(8-47))...
  28. ncbi [Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertension]
    Yong sheng Gong
    Institute of Cor Pulmonale and Teaching Centre of Functional Experiment, Wenzhou Medical College, Wenzhou, China
    Sheng Li Xue Bao 59:210-4. 2007
    The purpose of the present study was to explore the expression changes of intermedin/adrenomedullin 2 (IMD/ADM2), a novel small molecular bioactive peptide, and its receptors, calcitonin receptor-like receptor (CRLR) and receptor activity ..
  29. ncbi Protective effects of intermedin/adrenomedullin2 on ischemia/reperfusion injury in isolated rat hearts
    Jing Hui Yang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Peptides 26:501-7. 2005
    b>Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide (CT/CGRP) family identified from human and other vertebrate tissues...
  30. doi Expression of adrenomedullin 2/intermedin, a possible reno-protective peptide, is decreased in the kidneys of rats with hypertension or renal failure
    Takuo Hirose
    Dept of Clinical Pharmacology and Therapeutics, Tohoku Univ Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Aoba ku, Sendai 980 8578, Japan
    Am J Physiol Renal Physiol 299:F128-34. 2010
    Adrenomedullin 2/intermedin (AM2/IMD) is a potent vasodilator peptide with organ-protective effects and is abundantly expressed in the kidney...
  31. ncbi Intermedin functions as a pituitary paracrine factor regulating prolactin release
    Chia Lin Chang
    Stanford University School of Medicine, Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford, California 94305 5317, USA
    Mol Endocrinol 19:2824-38. 2005
    ..We recently identified intermedin (IMD) as a novel member of the calcitonin/calcitonin gene-related peptide family expressed in the pituitary, ..
  32. ncbi Intermedin/Adrenomedullin-2 inhibits growth hormone release from cultured, primary anterior pituitary cells
    Meghan M Taylor
    Saint Louis University, Pharmacological and Physiological Science, Missouri 63104, USA
    Endocrinology 147:859-64. 2006
    b>Intermedin (IMD), a novel member of the adrenomedullin (AM), calcitonin gene-related peptide (CGRP), amylin (AMY) peptide family, has been reported to act promiscuously at all the known receptors for these peptides...
  33. ncbi Intermedin/adrenomedullin-2 dilates the rat pulmonary vascular bed: dependence on CGRP receptors and nitric oxide release
    H Burak Kandilci
    Department of Pharmacology, Hacettepe University, Faculty of Pharmacy, 06100 Ankara, Turkey
    Peptides 27:1390-6. 2006
    b>Intermedin/adrenomedullin-2 (IMD/AM2) is a 47 amino acid peptide formed by enzymatic degradation of preprointermedin...
  34. ncbi Intermedin1-53 activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas
    Jing Hui Yang
    Institute of Cardiovascular Research, Peking University First Hospital, Beijing 100034, China
    Biochem Biophys Res Commun 341:567-72. 2006
    b>Intermedin (IMD), a novel member of the calcitonin/calcitonin gene-related peptide (CGRP) family, has similar or more potent vasodilatory and hypotensive actions than adrenomedullin (ADM) and CGRP...
  35. ncbi Adrenomedullin-2, a novel calcitonin/calcitonin-gene-related peptide family peptide, relaxes rat mesenteric artery: influence of pregnancy
    Madhu Chauhan
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555 1062, USA
    Endocrinology 148:1727-35. 2007
    Adrenomedullin-2 (ADM2), a novel calcitonin/calcitonin-gene-related peptide family peptide, is reported to reduce blood pressure in both normal and hypertensive rats...
  36. doi Adrenomedullin-2/intermedin induces cAMP accumulation in dissociated rat spinal cord cells: evidence for the existence of a distinct class of sites of action
    Ali Akbar Owji
    Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Fars, Iran
    J Mol Neurosci 35:355-61. 2008
    Adrenomedullin-2/intermedin is structurally related to the calcitonin family of peptides, which includes calcitonin gene-related peptide (CGRP), adrenomedullin, and amylin...
  37. doi Increased expression of adrenomedullin 2/intermedin in rat hearts with congestive heart failure
    Takuo Hirose
    Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 6 3 Aramaki Aza Aoba, Sendai 980 8578, Japan
    Eur J Heart Fail 10:840-9. 2008
    Adrenomedullin 2/intermedin (AM2/IMD) is a novel member of the calcitonin/calcitonin gene-related peptide family...
  38. pmc Mechanisms involved in the regional haemodynamic effects of intermedin (adrenomedullin 2) compared with adrenomedullin in conscious rats
    L Jolly
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, University of Nottingham, Nottingham, UK
    Br J Pharmacol 157:1502-13. 2009
    b>Intermedin (IMD) is a newly identified member of the calcitonin family of peptides that shares structural and functional homology with adrenomedullin (AM)...
  39. doi Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein
    Yan Cai
    Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China
    Cardiovasc Res 85:864-73. 2010
    ..Here, we investigated the expression of the novel peptide intermedin (IMD) in the vasculature, tested its ability to prevent VC in vivo and in vitro, and examined the mechanism ..
  40. ncbi [Intermedin (IMD) gene expression in hypertrophic cardiac myocyte of renal vascular hypertension rats and the intervention of Valsartan, Amlodipine and Enalapril in the expression]
    Jing Dong
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 26:1082-7. 2009
    This experiment on rats was aimed to investigate the expression of intermedin (IMD) in hypertrophic cardiac myoctye of renal vascular hypertension induced by incomplete ligation of the left renal artery, and so to detect and compare the ..
  41. doi Effect of intermedin1-53 on angiotensin II-induced hypertrophy in neonatal rat ventricular myocytes
    Jing Hui Yang
    Institute of Brain Science, Shanxi Datong University School of Medical Science, Datong, Shanxi, PR China
    J Cardiovasc Pharmacol 56:45-52. 2010
    b>Intermedin (IMD) is coexpressed in the heart with its receptor, which suggests that it may have localized actions as a modulator of cardiac function...