Adm

Summary

Gene Symbol: Adm
Description: adrenomedullin
Alias: H39316, RATAP, ADM
Species: rat

Top Publications

  1. pmc Adrenomedullin in rat follicles and corpora lutea: expression, functions and interaction with endothelin-1
    Lei Li
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Reprod Biol Endocrinol 9:111. 2011
  2. ncbi Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 35:912-8. 2007
  3. ncbi Cloning and expression of cDNA encoding a rat adrenomedullin receptor
    S Kapas
    Department of Chemical Endocrinology, Medical College, St Bartholomew s Hospital, London, United Kingdom
    J Biol Chem 270:25344-7. 1995
  4. ncbi Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide
    J Sakata
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 195:921-7. 1993
  5. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
  6. ncbi Placental and fetal growth and development in late rat gestation is dependent on adrenomedullin
    Andrea G Witlin
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biol Reprod 67:1025-31. 2002
  7. ncbi Co-expression of adrenomedullin and adrenomedullin receptors in rat epididymis: distinct physiological actions on anion transport
    Isabel S S Hwang
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 68:2005-12. 2003
  8. ncbi Vascular expression of adrenomedullin is increased in Wistar rats during early pregnancy
    Olivier W H van der Heijden
    Department of Obstetrics and Gynecology, Research Institute Growth and Development GROW, University Hospital Maastricht azM, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 123:35-40. 2005
  9. ncbi Adrenomedullin peptide: gene expression of adrenomedullin, its receptors and receptor activity modifying proteins, and receptor binding in rat testis--actions on testosterone secretion
    Yuk Yin Li
    Department of Physiology, The University of Hong Kong, Hong Kong
    Biol Reprod 75:183-8. 2006
  10. ncbi Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion
    Gonzalo J Carrizo
    Department of Surgery, North Shore University Hospital, Manhasset, NY, USA
    Surgery 141:245-53. 2007

Scientific Experts

Detail Information

Publications106 found, 100 shown here

  1. pmc Adrenomedullin in rat follicles and corpora lutea: expression, functions and interaction with endothelin-1
    Lei Li
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Reprod Biol Endocrinol 9:111. 2011
    Adrenomedullin (ADM), a novel vasorelaxant peptide, was found in human/rat ovaries...
  2. ncbi Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 35:912-8. 2007
    ..We therefore hypothesized that administration of AM/AMBP-1 would prevent metabolic acidosis after uncontrolled hemorrhage via down-regulation of endothelin-1...
  3. ncbi Cloning and expression of cDNA encoding a rat adrenomedullin receptor
    S Kapas
    Department of Chemical Endocrinology, Medical College, St Bartholomew s Hospital, London, United Kingdom
    J Biol Chem 270:25344-7. 1995
    ..Identification of this receptor cDNA should facilitate further investigation of the cellular actions of adrenomedullin and its regulatory effects in normal and disordered states of cardiovascular function...
  4. ncbi Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide
    J Sakata
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 195:921-7. 1993
    ..Synthetic rat adrenomedullin elicits a potent and long-lasting hypotensive activity in anesthetized rats...
  5. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
    ..RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors...
  6. ncbi Placental and fetal growth and development in late rat gestation is dependent on adrenomedullin
    Andrea G Witlin
    Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    Biol Reprod 67:1025-31. 2002
    ..Adrenomedullin contributes to angiogenesis, functions as a growth factor, and helps regulate vascular tone during rat gestation...
  7. ncbi Co-expression of adrenomedullin and adrenomedullin receptors in rat epididymis: distinct physiological actions on anion transport
    Isabel S S Hwang
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 68:2005-12. 2003
    ..Our results demonstrate the presence of AM, preproAM mRNA, AM receptors, and specific-binding sites in the rat epididymis as well as the possible role of AM in the regulation of electrolyte and fluid secretion in the epididymis...
  8. ncbi Vascular expression of adrenomedullin is increased in Wistar rats during early pregnancy
    Olivier W H van der Heijden
    Department of Obstetrics and Gynecology, Research Institute Growth and Development GROW, University Hospital Maastricht azM, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 123:35-40. 2005
    Circulating levels of adrenomedullin (ADM)--a vasodilator peptide with long-lasting effects--increase in the course of pregnancy. Neither the site nor the concomitant rate of ADM synthesis in pregnancy is known...
  9. ncbi Adrenomedullin peptide: gene expression of adrenomedullin, its receptors and receptor activity modifying proteins, and receptor binding in rat testis--actions on testosterone secretion
    Yuk Yin Li
    Department of Physiology, The University of Hong Kong, Hong Kong
    Biol Reprod 75:183-8. 2006
    Adrenomedullin (ADM) has been shown to be present in the human and rat male reproductive systems. This study demonstrates the expression of ADM in the rat testis and its effect on the secretion of testosterone...
  10. ncbi Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion
    Gonzalo J Carrizo
    Department of Surgery, North Shore University Hospital, Manhasset, NY, USA
    Surgery 141:245-53. 2007
    ..We hypothesized that administration of AM/AMBP-1 after gut ischemia-reperfusion (I/R) downregulates inflammatory cytokines and attenuates tissue injury...
  11. ncbi Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell
    Yuen Fan Chan
    Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Aging, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 78:773-9. 2008
    Based on the finding of gene expression of adrenomedullin (Adm) and its receptor components in the rat testis, a paracrine effect of ADM on testicular steroidogenesis has been suggested by our group...
  12. ncbi Adrenomedullin in the rat testis. II: Its production, actions on inhibin secretion, regulation by follicle-stimulating hormone, and its interaction with endothelin 1 in the Sertoli cell
    Yuen Fan Chan
    Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Aging, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 78:780-5. 2008
    The present study demonstrates the expression of adrenomedullin (ADM) in the rat Sertoli cells and its effect on inhibin production...
  13. doi Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary
    Yuk Yin Li
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 79:200-8. 2008
    The present study demonstrates the expression of adrenomedullin (ADM) in the reproductive system of the female rat and its effect on the secretion of estradiol and progesterone...
  14. pmc Human vasoactive hormone adrenomedullin and its binding protein rescue experimental animals from shock
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, United States
    Peptides 29:1223-30. 2008
    ..8 min and 1.68 h, respectively. Thus, administration of human AM/AMBP-1 may be a useful approach for attenuating organ injury, and reducing mortality after hemorrhagic shock...
  15. doi Role of adrenomedullin system in lipid metabolism and its signaling mechanism in cultured adipocytes
    Chikako Iemura-Inaba
    Dept of Hypertension and Cardiorenal Medicine, Dokkyo Univ School of Medicine, Mibu, Tochigi 321 0293, Japan
    Am J Physiol Regul Integr Comp Physiol 295:R1376-84. 2008
    ..These results indicate that AM and its receptor component are highly expressed in cultured adipocytes and may play a role in lipid metabolism via a different signaling pathway...
  16. pmc Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein
    Rongqian Wu
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, United States of America
    Mol Med 15:28-33. 2009
    ..Thus, human AM/AMBP-1 can be further developed as a safe and effective therapy for patients with established sepsis...
  17. pmc Human adrenomedullin and its binding protein attenuate organ injury and reduce mortality after hepatic ischemia-reperfusion
    Juntao Yang
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    Ann Surg 249:310-7. 2009
    ..To determine whether administration of a vasoactive peptide, human adrenomedullin (AM), in combination with its binding protein (ie, AMBP-1), prevents or minimizes hepatic ischemia-reperfusion (I/R) injury...
  18. pmc Attenuation of renal ischemia and reperfusion injury by human adrenomedullin and its binding protein
    Kavin G Shah
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    J Surg Res 163:110-7. 2010
    ..The objective of our study therefore was to determine whether administration of human AM/AMBP-1 can prevent and/or minimize damage in a rat model of renal I/R injury...
  19. pmc Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats
    Wayne W Chaung
    The Feinstein Institute for Medical Research, Manhasset, New York, USA
    Mol Med 17:1075-83. 2011
    ..Thus, human AM/AMBP-1 has the ability to reduce stroke-induced brain injury in rats. AM/AMBP-1 can be developed as a novel therapeutic agent for patients with ischemic stroke...
  20. ncbi Adrenomedullin antagonist treatment during early gestation in rats causes fetoplacental growth restriction through apoptosis
    Josthna Penchalaneni
    Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, USA
    Biol Reprod 71:1475-83. 2004
    ..In conclusion, these findings show that antagonism of AM in rats during early pregnancy caused fetoplacental growth restriction through the activation of mitochondrial apoptotic pathways...
  21. ncbi Adrenomedullin stimulates nitric oxide production from primary rat hypothalamic neurons: roles of calcium and phosphatases
    Yong Xu
    Department of Cell Biology, Center for Neuroscience, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2H7
    Mol Pharmacol 72:112-20. 2007
    Adrenomedullin (ADM) in the brain plays important roles in the maintenance of homeostasis...
  22. ncbi [Adrenomedullin in pregnancy]
    Ikuko Makino
    Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Nihon Yakurigaku Zasshi 120:99P-100P. 2002
    ..Thus AM may play an important role in the regulation of blood pressure, the blood supply to the utero-placental unit and fetal development...
  23. ncbi Expressions of adrenomedullin mRNA and protein in rats with hypobaric hypoxia-induced pulmonary hypertension
    Kuniaki Nakanishi
    Department of Pathology, National Defense Medical College, Tokorozawa 359 8513, Japan
    Am J Physiol Heart Circ Physiol 286:H2159-68. 2004
    ..During HHE, these changes in AM synthesis, which occurred strongly in the RV, occurred alongside the increase in PAP. Conceivably, AM may play a role in modulating pulmonary hypertension in HHE...
  24. ncbi The effect of vitamin E, L-arginine, N-nitro L-arginine methyl ester and forskolin on endocrine and metabolic changes of rats exposed to acute cold stress
    Laila Y Al-Ayadhi
    Department of Physiology 29, College of Medicine, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia
    Saudi Med J 27:17-22. 2006
    ..The current study assessed the effects of acute cold stress on adrenomedullin (ADM) levels in plasma and peripheral tissues (kidneys and heart) of rats, as well as on blood glucose, cholesterol, ..
  25. ncbi Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist
    T Miseki
    Division of Cancer Biology, Institute for Genetic Medicine, Hokkaido University, Hokkaido, Japan
    Cancer Gene Ther 14:39-44. 2007
    ..These results suggest that the intra-tumoral or intra-muscular transfer of naked DNA encoding AMA might be a promising alternative modality for treating human cancers...
  26. ncbi Age-related changes in adrenomedullin expression and hypoxia-inducible factor-1 activity in the rat lung and their responses to hypoxia
    Isabel S S Hwang
    Department of Physiology, Faculty of Medicine, University of Hong Kong, Pokfulam, China
    J Gerontol A Biol Sci Med Sci 62:41-9. 2007
    ..Thus, the HIF-AM pathway may be impaired in the aged lung, and other mechanisms may be present to maintain an AM response to hypoxia...
  27. ncbi Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock
    Bettina Temmesfeld-Wollbrück
    Department of Internal Medicine Infectious Diseases and Respiratory Medicine, Charite University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Intensive Care Med 33:703-10. 2007
    ..We tested the hypothesis that therapeutic administration of adrenomedullin would reduce vascular hyperpermeability, thereby contributing to improved hemodynamics and survival...
  28. pmc Mid-regional pro-adrenomedullin is associated with pulse pressure, left ventricular mass, and albuminuria in African Americans with hypertension
    Malik A Al-Omari
    Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Hypertens 22:860-6. 2009
    ..Biomarkers for early detection of target-organ damage in this ethnic group are needed. Adrenomedullin (ADM) is a circulating vasoactive peptide with vasodilatory and antiproliferative effects that has been reported to be ..
  29. doi Ethanol consumption alters the expression and reactivity of adrenomedullin in the rat mesenteric arterial bed
    Juliana T Rocha
    College of Nursing of Ribeirão Preto, University of Sao Paulo, Brazil
    Alcohol Alcohol 47:9-17. 2012
    ..We investigated the effects of chronic ethanol consumption on arterial blood pressure, vascular reactivity to AM and the expression of AM system components in the rat mesenteric arterial bed (MAB)...
  30. doi Preimplantation antagonism of adrenomedullin action compromises fetoplacental development and reduces litter size
    Lei Li
    Department of Physiology Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Theriogenology 77:1846-53. 2012
    Concentrations of adrenomedullin (ADM) in circulation, the uterus, and corpora lutea (CL) increase during pregnancy...
  31. doi Intrathecal adrenomedullin modulates acute inflammatory pain in the rat formalin test
    Yuki Sugimoto
    Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Neurosci Lett 552:146-50. 2013
    ..AM in the CSF contributes to the modulation of acute inflammatory pain in the formalin test, and blocking downstream signaling effects of the AM receptor has the potential to relieve pain associated with acute inflammation...
  32. pmc Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection
    Ryuichi Uetake
    Department of Cardiovascular Research, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    PLoS ONE 9:e87667. 2014
    ..The AM-RAMP2 system thus has the potential to serve as a therapeutic target in kidney disease...
  33. pmc Adrenomedullin promotes rat trophoblast stem cell differentiation
    Haijun Gao
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas
    Biol Reprod 91:65. 2014
    Accumulating data suggest that adrenomedullin (ADM) regulates the trophoblast cell growth, migration, and invasion. However, the effect of ADM on trophoblast differentiation is poorly understood...
  34. pmc Combination of adrenomedullin with its binding protein accelerates cutaneous wound healing
    Juan Pablo Idrovo
    Department of Surgery, Hofstra North Shore LIJ School of Medicine, Manhasset, New York, United States of America
    PLoS ONE 10:e0120225. 2015
    ..Treatment also shortened the days to reach plateau for wound closure. Thus, AM/AMBP-1 may be further developed as a therapeutic for cutaneous wound healing. ..
  35. doi Role of cerebellar adrenomedullin in blood pressure regulation
    Leticia Figueira
    School of Pharmacy, Laboratory of Neuropeptides, Universidad Central de Venezuela, Caracas Venezuela
    Neuropeptides 54:59-66. 2015
    ..Likewise; they constitute a novel mechanism of BP control which has not been described so far. ..
  36. ncbi Adrenomedullin, a new peptide, in patients with insulinoma
    C Letizia
    Department of Clinical Science, University of Rome La Sapienza, Italy
    Eur J Endocrinol 144:517-20. 2001
    ..It has been demonstrated that adrenomedullin, a newly discovered peptide, affects the release of insulin from pancreatic islets cells, suggesting a role in the insulin-regulating system...
  37. ncbi Cerebral endothelial cells are a major source of adrenomedullin
    B Kis
    Department of Physiology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Neuroendocrinol 14:283-93. 2002
    ..Cerebral endothelial cells are a potential source of adrenomedullin in the central nervous system, where adrenomedullin can also be involved in the regulation of neuroendocrine functions...
  38. ncbi Investigation of the effect of different regulatory peptides on adrenocortical cell proliferation in immature rats: evidence that endogenous adrenomedullin exerts a stimulating action
    Marcin Trejter
    Department of Histology and Embryology, School of Medicine, PL 60781 Poznan, Poland
    Int J Mol Med 10:81-4. 2002
    ..We investigated whether vasoactive intestinal peptide (VIP), atrial natriuretic peptide (ANP), adrenomedullin (ADM) and proadrenomedullin N-terminal 20 peptide (PAMP) play a relevant role in these mechanisms...
  39. ncbi Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: evidences of upregulation of ADM system in immature glands
    Piera Rebuffat
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Italy
    Int J Mol Med 10:85-8. 2002
    Evidence has been provided that adrenomedullin (ADM) stimulates the proliferative activity of adult rat adrenal zona glomerulosa (ZG)...
  40. ncbi Gastroprotective effect of adrenomedullin administered subcutaneously in the rat
    Giuseppe Clementi
    Department of Experimental and Clinical Pharmacology, School of Medicine, University of Catania, Catania, Italy
    Peptides 23:1149-53. 2002
    ..These results suggest that adrenomedullin exerts its antiulcer effect, when it is administered subcutaneously (s.c.), probably by a mechanism which involves somatostatin related transmission...
  41. ncbi Adrenomedullin over-expression in the caudate-putamen of the adult rat brain after ischaemia-reperfusion injury
    Juan Manuel Encinas
    Department of Neuroanatomy and Cell Biology, Instituto de Neurobiología Ramón y Cajal, CSIC, Avenida Doctor del Arce 37, 28002 Madrid, Spain
    Neurosci Lett 329:197-200. 2002
    ..Our findings suggest that the over-expression of AM and its changes in its intracellular location might be involved in the neuronal responses to brain ischaemia with a possible neuroprotector role...
  42. ncbi Adrenomedullin inhibits doxorubicin-induced cultured rat cardiac myocyte apoptosis via a cAMP-dependent mechanism
    Takeshi Tokudome
    Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Endocrinology 143:3515-21. 2002
    ..AM, as an autocrine factor, may play a protective role against cardiomyocyte injury by doxorubicin...
  43. ncbi Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats
    Charles E Dumont
    Departments of Orthopedic Surgery and Medicine, University of Zurich, Klinik Balgrist, Forchstrasse 340, 8008, Zurich, Switzerland
    Brain Res 955:64-71. 2002
    ..The co-expression of AM and its receptor in perineural fibroblasts and the expression of an AM receptor in Schwann cells suggest autocrine and/or paracrine modes of action of AM in peripheral nerves...
  44. ncbi Adrenomedullin overexpression to inhibit cuff-induced arterial intimal formation
    Masao Yamasaki
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hypertension 41:302-7. 2003
    ..Our findings suggest the possibility of a therapeutic use of the AM gene for the prevention of vascular proliferative disorders...
  45. ncbi Ventricular adrenomedullin system in the transition from LVH to heart failure in rats
    Toshio Nishikimi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Hypertension 41:512-8. 2003
    ..These results suggest that induction of the cardiac AM system, including the ligand, receptor, and amidating activity, may modulate pathophysiology during the transition from LVH to HF in this model...
  46. ncbi Role of the endogenous adrenomedullin system in regulating the secretion and growth of rat adrenal cortex
    Gian Paolo Rossi
    Department of Clinical and Experimental Medicine, University of Padua, Padua, Italy
    Hypertens Res 26:S85-92. 2003
    ....
  47. ncbi Increase in adrenomedullin gene expression in the left atrium and ventricle in the two-kidney one-clip renovascular hypertensive rats
    Isabel S S Hwang
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Sassoon Road, Pokfulam, Hong Kong, China
    Neuropeptides 37:239-44. 2003
    ..The lack of change in plasma AM level suggests a paracrine function for the peptide in this setting...
  48. ncbi The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats
    Keita Hiragushi
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Kidney Int 65:540-50. 2004
    ....
  49. ncbi Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension
    Noritoshi Nagaya
    Department of Internal Medicine, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 109:351-6. 2004
    ..Accordingly, we investigated the effects of AM inhalation on pulmonary hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension...
  50. ncbi Relationship between the contents of adrenomedullin and distributions of neutral endopeptidase in blood and tissues of spontaneously hypertensive rats
    Wei Jiang
    Institute of Cardiovascular Disease, Peking University First Hospital, Beijing, PR China
    Hypertens Res 27:109-17. 2004
    Adrenomedullin (ADM) is a multifunctional peptide with important roles in the cardiovascular system, especially in the adjustment of cardiovascular and renal homeostasis...
  51. ncbi A possible mechanism for the action of adrenomedullin in brain to stimulate stress hormone secretion
    Meghan M Taylor
    Saint Louis University, Department of Pharmacological and Physiological Science, 1402 South Grand Boulevard, St Louis, Missouri 63104, USA
    Endocrinology 145:4890-6. 2004
    ..In addition, AM given intracerebroventricularly stimulated the release of prolactin but did not alter the secretion of GH. We propose that AM produced in the brain may be an important neuromodulator of the hormonal stress response...
  52. ncbi Adrenomedullin as a sensitive marker for coronary and peripheral arterial complications in patients with atherosclerotic risks
    Yoshihiko Suzuki
    Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Peptides 25:1321-6. 2004
    ..Our findings suggest the possibility that plasma AM is a novel sensitive marker for the presence of vascular lesions in patients with atherosclerotic risks...
  53. ncbi Effects of adrenomedullin on aldosterone-induced cell proliferation in rat cardiac fibroblasts
    Wei Jiang
    Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China
    Biochim Biophys Acta 1690:265-75. 2004
    ..It also stimulates vascular smooth muscle cells to produce and secrete adrenomedullin (ADM), which has a cytoprotective effect against cardiovascular damage...
  54. ncbi Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide
    Yuk Yin Li
    Department of Physiology, Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    Neuropeptides 39:73-80. 2005
    ..The present results suggest that the biosynthesis and secretion of AM may be increased in cardiovascular tissues of rats injected with LPS, and that AM may play multiple roles in inflammation...
  55. ncbi Upregulation of adrenomedullin and its receptor components during cardiomyocyte hypertrophy induced by chronic inhibition of nitric oxide synthesis in rats
    David Bell
    Division of Medicine and Therapeutics, School of Medicine, The Queen s Univ of Belfast, Whitla Medical Bldg, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, United Kingdom
    Am J Physiol Heart Circ Physiol 290:H904-14. 2006
    ....
  56. ncbi Study on the signalling pathway of inhibitory effect of adreno-medullin on the growth of cultured glomerular mesangial cells
    Xue Guang Liu
    Department of Pathology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Chin Med J (Engl) 118:1374-9. 2005
    Adrenomedullin (ADM), a potent hypotensive small peptide, was recently found to inhibit the proliferation of glomerular mesangial cells (MsC) in vitro and to attenuate glomerular lesions in vivo, however the mechanisms remain poorly ..
  57. ncbi Possible involvement of adrenomedullin in lipopolysaccharide-induced small-intestinal motility changes in conscious rats
    Sarwar Hussain
    Department of Pediatrics and Developmental Medicine, Gunma University School of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    J Gastroenterol 40:1123-9. 2005
    ..The aim of this study was to test the effect of intravenous adrenomedullin on the motility pattern of the small intestine, and the functional involvement of adrenomedullin in endotoxin-induced small-intestinal motility disturbance...
  58. ncbi Identification and localization of adrenomedullin-storing cardiac mast cells
    Anna S Belloni
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 17:709-13. 2006
    ..Collectively, our findings provide evidence that at least a subset of cardiac mast cells are able to synthesize and store AM, and upon stimulation to release it near coronary arterioles and venules...
  59. ncbi Plasma adrenomedullin level and development of hypertension
    J Kato
    First Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    J Hum Hypertens 20:566-70. 2006
    ..The present findings suggest that an elevation of the plasma AM level associated with aging and increased BMI precedes the development of hypertension in the normotensive subjects...
  60. ncbi The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis
    Isabel Shui Shan Hwang
    Center for the Study of Liver Disease, The University of Hong Kong, Pokfulam, Hong Kong, China
    Regul Pept 135:69-77. 2006
    ..Given the potent vasodilatory action of AM, the increase in the synthesis and release of AM in the cirrhotic liver may also contribute to peripheral vasodilatation in liver cirrhosis...
  61. ncbi Expression of adrenomedullin in adipose tissue of lean and obese women
    O Paulmyer-Lacroix
    INSERM UMR 626, UFR de Médecine secteur Timone, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Eur J Endocrinol 155:177-85. 2006
    ..The aim of our study was to investigate the precise localization of AM within human adipose tissue, and to examine AM regulation in obesity...
  62. ncbi PTEN inhibits adrenomedullin expression and function in brain tumor cells
    Simone A Betchen
    Department of Neurosurgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Neurooncol 79:117-23. 2006
    ..Given the profound effects of adrenomedullin on tumor cells, this is a novel and previously unidentified mechanism by which alterations in PTEN levels or function may influence tumor growth...
  63. pmc A role for adrenomedullin as a pain-related peptide in the rat
    Weiya Ma
    Douglas Hospital Research Center, and Department of Psychiatry, McGill University, Montreal, QC, Canada H4H 1R3
    Proc Natl Acad Sci U S A 103:16027-32. 2006
    ..By activating specific receptors (likely AM2) and the PI3K/Akt/GSK3beta signaling pathway, AM could play a significant role in long-lasting heat hypersensitivity and inflammatory heat hyperalgesia...
  64. ncbi Adrenomedullin facilitates reinnervation of phenol-injured perivascular nerves in the rat mesenteric resistance artery
    N Hobara
    Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1 1 1 Tsushima naka, Okayama, Japan
    Neuroscience 144:721-30. 2007
    ..These results suggest that adrenomedullin, like NGF, has a facilitatory effect on the reinnervation of perivascular nerves...
  65. ncbi Differential regulation of adrenomedullin gene expression in the fundic and pyloric regions of the rat stomach during acute and chronic starvation
    Siu Yin Man
    Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Neuropeptides 41:177-87. 2007
    ..The present study suggests that the gene expression of preproadrenomedullin mRNA is differentially regulated by starvation in the different parts of the stomach...
  66. ncbi Changes in expression of adrenomedullin in the myocardium of streptozotocin-induced diabetic rats
    Rong xin He
    Department of Orthopaedics, Second Affiliated Hospital of Medical School, Zhejiang University, Hangzhou 310009, China
    Chin Med J (Engl) 120:187-91. 2007
    ..However, whether adrenomedullin is involved in the pathogenesis of diabetic cardiomyopathy is still unknown. Our aim was to characterize the expression pattern of adrenomedullin in the myocardium of streptozotocin-induced diabetic rats...
  67. ncbi Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR
    Vijaya Ramachandran
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:2666-75. 2007
    ..These data indicate that adrenomedullin acting via ADMR increases the aggressiveness of pancreatic cancer cells and suggests that these molecules may be useful therapeutic targets...
  68. ncbi The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: signaling pathway
    Xiao hui Zhang
    Department of Physiology and Institute of Cardiovascular Sciences and Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China, Hong Kong, China
    Am J Physiol Heart Circ Physiol 293:H2888-93. 2007
    Adrenomedullin (ADM) is upregulated in cardiac tissue under various pathophysiological conditions, particularly in septic shock...
  69. ncbi Up-regulation of adrenomedullin gene expression in the regenerating rat adrenal cortex
    Piera Rebuffat
    Department of Human Anatomy and Physiology, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 20:551-5. 2007
    ....
  70. pmc Adrenomedullin and adrenomedullin binding protein-1 protect endothelium-dependent vascular relaxation in sepsis
    Mian Zhou
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Mol Med 13:488-94. 2007
    ....
  71. doi Increased renal adrenomedullin expression in rats with ureteral obstruction
    Rikke Nørregaard
    The Water and Salt Research Center, Clinical Institute, Univ of Aarhus, Dept of Clinical Physiology and Nuclear Medicine, Aarhus Univ Hospital Skejby, Brendstrupgaardsvej, DK 8200 Aarhus N, Denmark
    Am J Physiol Regul Integr Comp Physiol 296:R185-92. 2009
    ..Hypoxia acting through HIF-1alpha accumulation may be an important pathway for the renal response to ureteral obstruction...
  72. doi Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine
    D M Glubb
    Gene Structure and Function Laboratory, Department of Pathology, University of Otago, Christchurch, New Zealand
    Pharmacogenomics J 10:126-33. 2010
    ..transcriptional changes were confirmed for 14 genes by qPCR and five of these, including the adrenomedullin gene (Adm), either approached or reached statistical significance...
  73. ncbi Adrenomedullin in the rostral ventrolateral medulla is involved in the regulation of cardiovascular component of defensive responses induced by electrical stimulation of dorsal periaquaductal gray of the midbrain
    Xia Li
    Department of Internal Neurology, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
    Sheng Li Xue Bao 61:347-55. 2009
    ..microinjection to investigate the changes of preproadrenomedullin (ppADM) gene expression encoding adrenomedullin (ADM) and ADM-like immunoreactivity (ADM-IR) in the medulla oblongata, especially in the rostral ventrolateral medulla (..
  74. doi A possible relationship between brain-derived adrenomedullin and oxytocin in the regulation of sodium balance
    Meghan M White
    Department of Pharmacological and Physiological Science, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Endocrinol 203:253-62. 2009
    ....
  75. doi Adrenomedullin promotes lung angiogenesis, alveolar development, and repair
    Arul Vadivel
    Department of Pediatrics, Women and Children s Health Research Institute, University of Alberta, Edmonton, Canada
    Am J Respir Cell Mol Biol 43:152-60. 2010
    ..Our findings suggest a role for AM during normal alveolar development. AM may have therapeutic potential in diseases associated with alveolar injury...
  76. doi Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
    Erik Øie
    Department of Cardiology, Rikshospitalet University Hospital, University of Oslo, 0027 Oslo, Norway
    Basic Res Cardiol 105:89-98. 2010
    ..Finally, a net release of AM from the lungs into the circulation was only found in patients with severe systolic dysfunction...
  77. doi Adrenomedullin is expressed during rodent dental tissue development and promotes cell growth and mineralization
    David S Musson
    Oral Biology, School of Dentistry, University of Birmingham, Birmingham B4 6NN, UK
    Biol Cell 102:145-57. 2010
    b>ADM (adrenomedullin) has pleiotropic effects, including regulation of inflammation, infection, angiogenesis, mineralized-tissue formation and development...
  78. doi Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis
    Bettina Geissler
    Kinder und Jugendklinik, Erlangen, Germany
    Nephron Exp Nephrol 115:e80-8. 2010
    Adrenomedullin (ADM) has antiproliferative effects on glomerular mesangial cells. The study was performed to determine changes in glomerular gene expression of the ADM system by ADM treatment in anti-Thy1 glomerulonephritis (GN).
  79. pmc Coexpression of adrenomedullin and its receptor component proteins in the reproductive system of the rat during gestation
    Lei Li
    Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Reprod Biol Endocrinol 8:130. 2010
    Adrenomedullin (ADM), a novel vasorelaxant peptide, was found in human/rat ovaries and uteri. Plasma ADM level increases in pregnant women and pregnant rats.
  80. doi Adrenomedullin increases ciliary beat frequency and decreases muscular contraction in the rat oviduct
    S B Liao
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, People s Republic of China
    Reproduction 141:367-72. 2011
    Our laboratory previously showed that oviduct produced the greatest amount of adrenomedullin (ADM) in the rat female reproductive tract...
  81. pmc Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats
    David H T Yen
    Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Biomed Sci 18:32. 2011
    Adrenomedullin (ADM) exerts its biological functions through the receptor-mediated enzymatic mechanisms that involve protein kinase A (PKA), or neuronal nitric oxide synthase (nNOS)...
  82. doi Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats
    Jing Zhang
    School of P E and Sports Science, Beijing Normal University, Beijing 100875, China
    Peptides 32:1415-21. 2011
    Adrenomedullin (ADM) has been recognized as a multipotent multifunctional peptide...
  83. pmc Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage
    X Wang
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA
    Proc Natl Acad Sci U S A 92:11480-4. 1995
    ....
  84. ncbi Adrenomedullin expression is up-regulated by ischemia-reperfusion in the cerebral cortex of the adult rat
    J Serrano
    Department of Neuroanatomy and Cell Biology, Instituto Cajal Madrid, Spain
    Neuroscience 109:717-31. 2002
    ..In summary, adrenomedullin expression is elevated after the ischemic insult and seems to be part of CNS response mechanism to hypoxic injury...
  85. ncbi Rapid increase in cardiac adrenomedullin gene expression caused by acute pressure overload: effect of the renin-angiotensin system on gene expression
    Shuji Hirano
    First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
    Circ J 66:397-402. 2002
    ..In conclusion, POL induces a rapid increase in cardiac AM gene expression and in plasma AM concentrations. Cardiac AM transcription could therefore be partly regulated by RAS in suprarenal aortic banding rats...
  86. ncbi Ribozyme compromise of adrenomedullin mRNA reveals a physiological role in the regulation of water intake
    Meghan M Taylor
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1739-45. 2002
    ....
  87. ncbi Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure
    Carine Cueille
    INSERM U349, Hopital Lariboisiere, Centre Viggo Petersen, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Biochem Biophys Res Commun 294:340-6. 2002
    Calcitonin gene-related peptide (CGRP) and adrenomedullin (ADM) are potent vasodilators in humans and improved myocardial ischemia is observed after CGRP administration. Receptors for CGRP and ADM were already identified in heart...
  88. ncbi Chronic salt loading upregulates expression of adrenomedullin and its receptors in adrenal glands and kidneys of the rat
    Yuan Ning Cao
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Hypertension 42:369-72. 2003
    ..Taken together, these results suggest that AM plays a role in the regulation of water and electrolyte balance in animals chronically ingesting high levels of salt...
  89. ncbi Expression of adrenomedullin in hypoxic and ischemic rat kidneys and human kidneys with arterial stenosis
    Peter Sandner
    Dept of Physiology and Pharmacology, University of Southern Denmark, Winsløwparken 21, no 3, DK 5000 Odense, Denmark
    Am J Physiol Regul Integr Comp Physiol 286:R942-51. 2004
    ..AM was widely distributed in the human kidney with arterial stenosis. AM may play a significant role to counteract hypoxia in the kidney...
  90. ncbi Antioxidant effect of adrenomedullin on angiotensin II-induced reactive oxygen species generation in vascular smooth muscle cells
    Takanobu Yoshimoto
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8513, Japan
    Endocrinology 145:3331-7. 2004
    ..These data suggest that AM plays a protective role as an endogenous antioxidant in Ang II-induced vascular injury...
  91. ncbi Effects of adrenomedullin on cell proliferation in rat adventitia induced by lysophosphatidic acid
    Jing Hui Yang
    Institute of Cardiovascular Disease, Peking University First Hospital, Beijing 100034, China
    Regul Pept 121:49-56. 2004
    ..Among various bioactive factors that LPA works with, adrenomedullin (ADM) is a multiple functional peptide with an important cytoprotective effect against cardiovascular damage...
  92. ncbi Concomitant expression of adrenomedullin and its receptor components in rat adipose tissues
    Nozomi Fukai
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8513, Japan
    Am J Physiol Endocrinol Metab 288:E56-62. 2005
    ..These data suggest that AM may act as a new member of adipokines, although its functional role, as well as its pathophysiological significance in obesity, remains to be determined...
  93. ncbi Adrenomedullin is both proinflammatory and antiinflammatory: its effects on gene expression and secretion of cytokines and macrophage migration inhibitory factor in NR8383 macrophage cell line
    Louisa Y F Wong
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Endocrinology 146:1321-7. 2005
    Adrenomedullin (ADM) is a potent vasorelaxant peptide that plays important roles in cardiovascular homeostasis and inflammatory response...
  94. ncbi Adrenomedullin expression in a rat model of acute lung injury induced by hypoxia and LPS
    Jackeline Agorreta
    Division of Oncology, Center for Applied Medical Research, University of Navarra, Navarra, Spain
    Am J Physiol Lung Cell Mol Physiol 288:L536-45. 2005
    Adrenomedullin (ADM) is upregulated independently by hypoxia and LPS, two key factors in the pathogenesis of acute lung injury (ALI)...
  95. ncbi Adrenomedullin (AM) and receptor-activity-modifying proteins in glomeruli with Thy.1 glomerulonephritis
    Michitaka Matsumoto
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki gun, Miyazaki, 889 1692 Japan
    Clin Exp Nephrol 8:316-21. 2004
    ..Adrenomedullin (AM) has antiproliferative and proapoptotic effects on mesangial cells in culture, but the regulation of AM and its receptors in glomeruli with glomerulonephritis have not been clarified...
  96. ncbi Upregulation of intracardiac adrenomedullin and its receptor system in rats with volume overload-induced cardiac hypertrophy
    Fumiki Yoshihara
    Division of Hypertension and Nephrology, National Cardiovascular Center, Fujishirodai, Suita, Osaka 565 8565, Japan
    Regul Pept 127:239-44. 2005
    ..42). These results suggest that intracardiac adrenomedullin and its receptor system are upregulated and may participate in the regulation of cardiac remodeling in volume overload-induced cardiac hypertrophy...
  97. ncbi Adrenomedullin protects rat cerebral endothelial cells from oxidant damage in vitro
    Lei Chen
    Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Regul Pept 130:27-34. 2005
    ..These results suggest that AM treatment protects CECs against oxidative injury...
  98. ncbi Adrenomedullin and vascular endothelium growth factor genes are overexpressed in the regenerating rat adrenal cortex, and AM and VEGF reciprocally enhance their mRNA expression in cultured rat adrenocortical cells
    Giovanna Albertin
    Department of Human Anatomy and Physiology, Section of Anatomy, Padova, Italy
    Int J Mol Med 16:431-5. 2005
    ....
  99. ncbi Peripheral adrenomedullin inhibits gastric emptying through CGRP8-37 -sensitive receptors and prostaglandins pathways in rats
    V Martinez
    CURE Digestive Diseases Research Center, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Peptides 27:1376-82. 2006
    ..These data indicate that peripheral AM inhibits gastric emptying through the interaction with CGRP8-37 -sensitive receptors, likely CGRP1 receptors, and the recruitment of prostaglandin-dependent mechanisms...
  100. ncbi Adrenomedullin gene transfer induces neointimal apoptosis and inhibits neointimal hyperplasia in injured rat artery
    Tanja Rauma-Pinola
    Department of Pharmacology and Toxicology, University of Oulu, Biocenter Oulu, Oulu, Finland
    J Gene Med 8:452-8. 2006
    ..We conclude that AM overexpression inhibits neointimal growth. The inhibition is associated with enhanced apoptosis of the neointimal cells which may be of myofibroblast origin...
  101. ncbi Increased production of adrenomedullin in glomeruli from anti-glomerular basement membrane glomerulonephritis rats treated with methylprednisolone
    Shuji Iwatsubo
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Nephron Exp Nephrol 104:e41-7. 2006
    ..Glucocorticoids are widely used for the treatment of GN; however, the relationship between AM regulation in MCs or glomeruli and glucocorticoid treatment has not been clarified...