SLC12A2

Summary

Gene Symbol: SLC12A2
Description: solute carrier family 12 member 2
Alias: NKCC1, solute carrier family 12 member 2, Na-K-2Cl- cotransporter, solute carrier family 12 (sodium/potassium/chloride transporter), member 2
Species: rabbit

Top Publications

  1. pmc Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia
    Yukitaka Morita
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, Department of Psychiatry, Hiroshima City Hospital, Hiroshima City, Hiroshima Prefecture, 730 8518, Japan, Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland 21205, Neurodevelopmental and Neuropsychiatric Genetics Laboratory, Departments of Psychiatry and Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, and Departments of Psychiatry, Neurology, Neuroscience and the McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Neurosci 34:4929-40. 2014
  2. pmc KCC2 expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses
    Peter H Frederikse
    Rutgers SDM, Oral Biology, New Jersey, Newark, NJ
    Mol Vis 21:1142-50. 2015
  3. pmc Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD
    Wen Liu
    Division of Pediatric Nephrology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Physiol Renal Physiol 301:F1088-97. 2011

Detail Information

Publications3

  1. pmc Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia
    Yukitaka Morita
    Clinical Brain Disorders Branch, Genes, Cognition, and Psychosis Program, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, Department of Psychiatry, Hiroshima City Hospital, Hiroshima City, Hiroshima Prefecture, 730 8518, Japan, Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland 21205, Neurodevelopmental and Neuropsychiatric Genetics Laboratory, Departments of Psychiatry and Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, and Departments of Psychiatry, Neurology, Neuroscience and the McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Neurosci 34:4929-40. 2014
    Early in development, GABA, an inhibitory neurotransmitter in adults, is excitatory. NKCC1 (SLC12A2) encodes one of two cation chloride cotransporters mediating the conversion of GABA from excitatory to inhibitory...
  2. pmc KCC2 expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses
    Peter H Frederikse
    Rutgers SDM, Oral Biology, New Jersey, Newark, NJ
    Mol Vis 21:1142-50. 2015
    Na-K-Cl cotransporter 1 (NKCC1) and K-Cl cotransporter 2 (KCC2) have fundamental roles in neuron differentiation that are integrated with gamma-aminobutyric acid (GABA) and glutamate receptors, GABA synthesized by GAD25/65/67 encoded by ..
  3. pmc Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD
    Wen Liu
    Division of Pediatric Nephrology, Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Physiol Renal Physiol 301:F1088-97. 2011
    ..Quantitative PCR performed on single CCD samples using NKCC1- and 18S-specific primers and probes and the TaqMan assay confirmed the presence of the transcript in this nephron ..