Genomes and Genes
Gene Symbol: CACH2C
Description: cardiac L-type calcium channel
Alias: CACH2, CACN2, CACNL1A1, CCHL1A1, Cacna1c, Voltage-dependent L-type calcium channel subunit alpha-1C
- Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channelAdva Benmocha Guggenheimer
a Department of Physiology and Pharmacology Sackler School of Medicine Sagol School of Neuroscience Tel Aviv, Israel
Channels (Austin) 10:55-68. 2016..We hypothesize that Ca(2+)-CaM-induced changes in NT-CT interaction may, in part, underlie the acceleration of CaV1.2 inactivation induced by Ca(2+) entry into the cell. ..
- Phosphorylation sites in the Hook domain of CaVβ subunits differentially modulate CaV1.2 channel functionSylvain Brunet
Department of Pharmacology, University of Washington, Seattle, WA 98195, United States Department of Neurosciences, Cleveland Clinic Organization, Cleveland, OH 44195, United States
J Mol Cell Cardiol 87:248-56. 2015..These results reveal a new dimension of regulation of Ca(V)1.2 channels through phosphorylation of the Hook domains of their β subunits...
- Asn-Linked Glycosylation Contributes to Surface Expression and Voltage-Dependent Gating of Cav1.2 Ca²⁺ ChannelHyun Jee Park
Department of Life Science, Sogang University, Seoul 121 742, Republic of Korea
J Microbiol Biotechnol 25:1371-9. 2015..2/WT. Tunicamycin treatment of oocytes expressing Cav1.2/WT mimicked the effects of the quadruple mutations. These findings suggest that Nglycosylation contributes to the surface expression and voltage-dependent gating of Cav1.2...
- Graded Ca²⁺/calmodulin-dependent coupling of voltage-gated CaV1.2 channelsRose E Dixon
Department of Physiology and Biophysics, University of Washington, Seattle, United States
elife 4:. 2015..2 channel gating and Ca(2+)-influx amplification that unifies diverse observations about Ca(2+) signaling in the heart, and challenges the long-held view that voltage-gated channels open and close independently. ..
- Homer proteins mediate the interaction between STIM1 and Cav1.2 channelsNatalia Dionisio
Department of Physiology Cell Physiology Research Group, University of Extremadura, 10003 Caceres, Spain
Biochim Biophys Acta 1853:1145-53. 2015..2-expressing cells. Altogether, these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1...
- Structural flexibility of CaV1.2 and CaV2.2 I-II proximal linker fragments in solutionLior Almagor
Department of Biochemistry and Molecular Biology, Institute of Structure Biology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
Biophys J 104:2392-400. 2013..Our analysis also provides a robust example of investigating protein domains in which flexibility plays an essential role...
- Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of Gβγ and protein kinase CSharon Weiss
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Channels (Austin) 6:426-37. 2012..Our results suggest a complex antagonistic interplay between G(q)-activated PKC and Gβγ in regulation of L-VDCC, in which multiple cytosolic segments of α(1C) are involved...
- Thyroid hormone increased L-type calcium channel mRNA expression and L-type calcium current of myocytes in rabbitsZhui Yu
Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China
Biomed Mater Eng 22:49-55. 2012..To investigate the effects of thyroid hormone on L-type calcium channel mRNA and L-type calcium current of atrium and ventricle...
- Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricleEman S H Abd Allah
Cardiovascular Medicine, Faculty of Medical and Human Sciences, University of Manchester, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK
J Mol Cell Cardiol 53:145-55. 2012..It is concluded that many of the well known transmural gradients in the ventricle develop postnatally...
- Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributesGiovanni Gonzalez-Gutierrez
Institut fur Neurophysiologie, Medizinische Hochschule Hannover, Hannover, Germany
Channels (Austin) 4:42-50. 2010....
- Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2Hui Xu
Department of Pharmacology, University of Iowa, Iowa City, IA 52242 1109, USA
Biochemistry 49:10298-307. 2010..2 in the heart negatively regulates cardiac L-type currents, likely by counterbalancing basal and stimulated phosphorylation that is mediated by PKA and possibly other kinases...
- Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndromeManuel F Navedo
Department of Physiology and Biophysics, University of Washington Seattle, 1705 NE Pacific Street, Seattle, WA 98195, USA
Circ Res 106:748-56. 2010..L-Type (Cav1.2) Ca(2+) channels are critical regulators of muscle and neural function. Although Cav1.2 channel activity varies regionally, little is known about the mechanisms underlying this heterogeneity...
- Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channelA Yoshida
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
FEBS Lett 309:343-9. 1992..These results suggested that the cardiac DHP-sensitive Ca channel was regulated by cAMP-dependent phosphorylation of the alpha 1 subunit...
- Ca(v)1.2 splice variant with exon 9* is critical for regulation of cerebral artery diameterMatthew A Nystoriak
Department of Pharmacology and Surgery, University of Vermont, College of Medicine, Burlington, VT 05405 0068, USA
Am J Physiol Heart Circ Physiol 297:H1820-8. 2009..We conclude that although cerebral artery myocytes express both alpha(1)C(9/9*/10) and alpha(1)C(9/10) VDCC splice variants, alpha(1)C(9/9*/10) is functionally dominant in the control of cerebral artery diameter...
- Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha1C subunit in rabbitsMark R Fowler
Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
Exp Physiol 93:1233-8. 2008..These data suggest that sorcin interacts with LTCC via its C-terminal domain, which alters current magnitude and tau(fast). These effects appear to be influenced by the prevailing experimental conditions...
- A mutation affecting dihydropyridine-sensitive current levels and activation kinetics in Drosophila muscle and mammalian heart calcium channelsD Ren
Department of Biochemical Pharmacology, State University of New York at Buffalo, Buffalo, New York 14260 1200, USA
J Neurosci 18:2335-41. 1998..Amino acid substitutions at this Cys position in the cardiac alpha1 subunit show that the size of the side chain, rather than its ability to form disulfide bonds, affects channel activation...
- Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channelsJ Yang
Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, California 94305
Nature 366:158-61. 1993..Competition among Ca2+ ions for individual glutamates, together with repulsive ion-ion electrostatic interaction, may help achieve rapid flux rates through the channel...
- Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunitM Pragnell
Howard Hughes Medical Institute, Department of Physiology, University of Iowa College of Medicine, Iowa City 52242
Nature 368:67-70. 1994..Conservation of the beta-subunit binding motif in these functionally distinct calcium channels suggests a critical role for the I-II cytoplasmic linker of the alpha 1-subunit in channel modulation by the beta-subunit...
- Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channelsM De Leon
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Science 270:1502-6. 1995..Donation of the alpha 1C EF-hand region to the alpha 1E channel conferred the Ca(2+)-inactivating phenotype. These results strongly suggest that Ca2+ binding to the alpha 1C subunit initiates Ca2+ inactivation...
- Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channelA Mikami
Department of Medical Chemistry Kyoto University Faculty of Medicine, Japan
Nature 340:230-3. 1989..Furthermore, higher calcium-channel activity is observed when mRNA specific for the polypeptide of relative molecular mass approximately 140,000 (alpha 2-subunit) associated with skeletal muscle DHP receptor is co-injected...
- Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genesE Perez-Reyes
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
J Biol Chem 265:20430-6. 1990..These results demonstrate that calcium channel diversity is created by both the expression of distinct genes and the alternate splicing of these genes...
- Primary structure and functional expression of a high voltage activated calcium channel from rabbit lungM Biel
Medizinische Biochemie, Universitat des Saarlandes, Homburg Saar, FRG
FEBS Lett 269:409-12. 1990..Synthetic RNA derived from this cDNA induces the formation of a functional CaCB-sensitive high voltage activated calcium channel in Xenopus oocytes...
- Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channelsM Biel
Institut für Medizinische Biochemie, Medizinische Fakultat, Universitat des Saarlandes, Homburg, Federal Republic of Germany
Eur J Biochem 200:81-8. 1991..cloning of the cDNA for the alpha 1 subunit of L-type calcium channels revealed that at least two genes (CaCh1 and CaCh2) exist which give rise to several splice variants...