CACH2C

Summary

Gene Symbol: CACH2C
Description: cardiac L-type calcium channel
Alias: CACH2, CACN2, CACNL1A1, CCHL1A1, Cacna1c, Voltage-dependent L-type calcium channel subunit alpha-1C
Species: rabbit

Top Publications

  1. pmc Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel
    Adva Benmocha Guggenheimer
    a Department of Physiology and Pharmacology Sackler School of Medicine Sagol School of Neuroscience Tel Aviv, Israel
    Channels (Austin) 10:55-68. 2016
  2. pmc Phosphorylation sites in the Hook domain of CaVβ subunits differentially modulate CaV1.2 channel function
    Sylvain Brunet
    Department of Pharmacology, University of Washington, Seattle, WA 98195, United States Department of Neurosciences, Cleveland Clinic Organization, Cleveland, OH 44195, United States
    J Mol Cell Cardiol 87:248-56. 2015
  3. doi Asn-Linked Glycosylation Contributes to Surface Expression and Voltage-Dependent Gating of Cav1.2 Ca²⁺ Channel
    Hyun Jee Park
    Department of Life Science, Sogang University, Seoul 121 742, Republic of Korea
    J Microbiol Biotechnol 25:1371-9. 2015
  4. pmc Graded Ca²⁺/calmodulin-dependent coupling of voltage-gated CaV1.2 channels
    Rose E Dixon
    Department of Physiology and Biophysics, University of Washington, Seattle, United States
    elife 4:. 2015
  5. doi Homer proteins mediate the interaction between STIM1 and Cav1.2 channels
    Natalia Dionisio
    Department of Physiology Cell Physiology Research Group, University of Extremadura, 10003 Caceres, Spain
    Biochim Biophys Acta 1853:1145-53. 2015
  6. pmc Structural flexibility of CaV1.2 and CaV2.2 I-II proximal linker fragments in solution
    Lior Almagor
    Department of Biochemistry and Molecular Biology, Institute of Structure Biology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    Biophys J 104:2392-400. 2013
  7. pmc Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of Gβγ and protein kinase C
    Sharon Weiss
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Channels (Austin) 6:426-37. 2012
  8. doi Thyroid hormone increased L-type calcium channel mRNA expression and L-type calcium current of myocytes in rabbits
    Zhui Yu
    Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China
    Biomed Mater Eng 22:49-55. 2012
  9. doi Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle
    Eman S H Abd Allah
    Cardiovascular Medicine, Faculty of Medical and Human Sciences, University of Manchester, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK
    J Mol Cell Cardiol 53:145-55. 2012
  10. ncbi Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes
    Giovanni Gonzalez-Gutierrez
    Institut fur Neurophysiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Channels (Austin) 4:42-50. 2010

Scientific Experts

  • Zhui Yu
  • Lior Almagor
  • Manuel F Navedo
  • Adva Benmocha Guggenheimer
  • Rose E Dixon
  • Sylvain Brunet
  • Hyun Jee Park
  • Natalia Dionisio
  • Joel A Hirsch
  • Nathan Dascal
  • Can Yuan
  • Luis F Santana
  • Sharon Weiss
  • Eman S H Abd Allah
  • Hui Xu
  • Giovanni Gonzalez-Gutierrez
  • Matthew A Nystoriak
  • Mark R Fowler
  • Vladimir Tsemakhovich
  • Debi Ranjan Tripathy
  • Ximena Opitz-Araya
  • Se Hong Min
  • Gines M Salido
  • William A Catterall
  • Michelle A Emrick
  • Martin Sadilek
  • Todd Scheuer
  • Antonio Castellano
  • Tarik Smani
  • Marc D Binder
  • Yu Jin Won
  • Geoffrey E Woodard
  • Claudia M Moreno
  • Jung Ha Lee
  • Juan A Rosado
  • Ram Avinery
  • Roy Beck
  • Oleg V Aslanidi
  • Hannelore Haase
  • James O Tellez
  • Adva Ben Mocha
  • Shimrit Oz
  • Mark R Boyett
  • Joseph Yanni
  • Henggui Zhang
  • Halina Dobrzynski
  • Rudi Billeter
  • Tal Keren-Raifman
  • Donald Bers
  • Johannes W Hell
  • Kenneth S Ginsburg
  • Erick Miranda-Laferte
  • Maike Zimmermann
  • Joseph A Hill
  • Jeffery D Molkentin
  • Patricia Hidalgo
  • Alan Neely
  • Mingxu Zhang
  • Edward P Cheng
  • Gustavo Contreras
  • John D Scott
  • Samvit Tandan
  • Mary C Horne
  • Scott Votaw
  • Duane D Hall
  • Ivar S Stein
  • Kentaro Murakami
  • Paul L Penar
  • George C Wellman
  • Ian M Fearon
  • Godfrey L Smith
  • Gianni Colotti
  • Emilia Chiancone
  • D Ren
  • M De Leon
  • T P Snutch
  • M Pragnell
  • D F Eberl
  • L M Hall
  • M Chopra
  • H Xu
  • E Perez-Reyes
  • J Yang
  • Y Wang
  • T Tanabe
  • L Jones
  • D T Yue
  • Y Mori
  • T W Soong
  • X Wei

Detail Information

Publications23

  1. pmc Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel
    Adva Benmocha Guggenheimer
    a Department of Physiology and Pharmacology Sackler School of Medicine Sagol School of Neuroscience Tel Aviv, Israel
    Channels (Austin) 10:55-68. 2016
    ..We hypothesize that Ca(2+)-CaM-induced changes in NT-CT interaction may, in part, underlie the acceleration of CaV1.2 inactivation induced by Ca(2+) entry into the cell. ..
  2. pmc Phosphorylation sites in the Hook domain of CaVβ subunits differentially modulate CaV1.2 channel function
    Sylvain Brunet
    Department of Pharmacology, University of Washington, Seattle, WA 98195, United States Department of Neurosciences, Cleveland Clinic Organization, Cleveland, OH 44195, United States
    J Mol Cell Cardiol 87:248-56. 2015
    ..These results reveal a new dimension of regulation of Ca(V)1.2 channels through phosphorylation of the Hook domains of their β subunits...
  3. doi Asn-Linked Glycosylation Contributes to Surface Expression and Voltage-Dependent Gating of Cav1.2 Ca²⁺ Channel
    Hyun Jee Park
    Department of Life Science, Sogang University, Seoul 121 742, Republic of Korea
    J Microbiol Biotechnol 25:1371-9. 2015
    ..2/WT. Tunicamycin treatment of oocytes expressing Cav1.2/WT mimicked the effects of the quadruple mutations. These findings suggest that Nglycosylation contributes to the surface expression and voltage-dependent gating of Cav1.2...
  4. pmc Graded Ca²⁺/calmodulin-dependent coupling of voltage-gated CaV1.2 channels
    Rose E Dixon
    Department of Physiology and Biophysics, University of Washington, Seattle, United States
    elife 4:. 2015
    ..2 channel gating and Ca(2+)-influx amplification that unifies diverse observations about Ca(2+) signaling in the heart, and challenges the long-held view that voltage-gated channels open and close independently. ..
  5. doi Homer proteins mediate the interaction between STIM1 and Cav1.2 channels
    Natalia Dionisio
    Department of Physiology Cell Physiology Research Group, University of Extremadura, 10003 Caceres, Spain
    Biochim Biophys Acta 1853:1145-53. 2015
    ..2-expressing cells. Altogether, these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1...
  6. pmc Structural flexibility of CaV1.2 and CaV2.2 I-II proximal linker fragments in solution
    Lior Almagor
    Department of Biochemistry and Molecular Biology, Institute of Structure Biology, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    Biophys J 104:2392-400. 2013
    ..Our analysis also provides a robust example of investigating protein domains in which flexibility plays an essential role...
  7. pmc Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of Gβγ and protein kinase C
    Sharon Weiss
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Channels (Austin) 6:426-37. 2012
    ..Our results suggest a complex antagonistic interplay between G(q)-activated PKC and Gβγ in regulation of L-VDCC, in which multiple cytosolic segments of α(1C) are involved...
  8. doi Thyroid hormone increased L-type calcium channel mRNA expression and L-type calcium current of myocytes in rabbits
    Zhui Yu
    Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China
    Biomed Mater Eng 22:49-55. 2012
    ..To investigate the effects of thyroid hormone on L-type calcium channel mRNA and L-type calcium current of atrium and ventricle...
  9. doi Postnatal development of transmural gradients in expression of ion channels and Ca²⁺-handling proteins in the ventricle
    Eman S H Abd Allah
    Cardiovascular Medicine, Faculty of Medical and Human Sciences, University of Manchester, Core Technology Facility, 46 Grafton Street, Manchester M13 9NT, UK
    J Mol Cell Cardiol 53:145-55. 2012
    ..It is concluded that many of the well known transmural gradients in the ventricle develop postnatally...
  10. ncbi Swapping the I-II intracellular linker between L-type CaV1.2 and R-type CaV2.3 high-voltage gated calcium channels exchanges activation attributes
    Giovanni Gonzalez-Gutierrez
    Institut fur Neurophysiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Channels (Austin) 4:42-50. 2010
    ....
  11. pmc Targeting of protein phosphatases PP2A and PP2B to the C-terminus of the L-type calcium channel Ca v1.2
    Hui Xu
    Department of Pharmacology, University of Iowa, Iowa City, IA 52242 1109, USA
    Biochemistry 49:10298-307. 2010
    ..2 in the heart negatively regulates cardiac L-type currents, likely by counterbalancing basal and stimulated phosphorylation that is mediated by PKA and possibly other kinases...
  12. pmc Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome
    Manuel F Navedo
    Department of Physiology and Biophysics, University of Washington Seattle, 1705 NE Pacific Street, Seattle, WA 98195, USA
    Circ Res 106:748-56. 2010
    ..L-Type (Cav1.2) Ca(2+) channels are critical regulators of muscle and neural function. Although Cav1.2 channel activity varies regionally, little is known about the mechanisms underlying this heterogeneity...
  13. ncbi Cyclic AMP-dependent phosphorylation and regulation of the cardiac dihydropyridine-sensitive Ca channel
    A Yoshida
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    FEBS Lett 309:343-9. 1992
    ..These results suggested that the cardiac DHP-sensitive Ca channel was regulated by cAMP-dependent phosphorylation of the alpha 1 subunit...
  14. pmc Ca(v)1.2 splice variant with exon 9* is critical for regulation of cerebral artery diameter
    Matthew A Nystoriak
    Department of Pharmacology and Surgery, University of Vermont, College of Medicine, Burlington, VT 05405 0068, USA
    Am J Physiol Heart Circ Physiol 297:H1820-8. 2009
    ..We conclude that although cerebral artery myocytes express both alpha(1)C(9/9*/10) and alpha(1)C(9/10) VDCC splice variants, alpha(1)C(9/9*/10) is functionally dominant in the control of cerebral artery diameter...
  15. doi Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha1C subunit in rabbits
    Mark R Fowler
    Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Exp Physiol 93:1233-8. 2008
    ..These data suggest that sorcin interacts with LTCC via its C-terminal domain, which alters current magnitude and tau(fast). These effects appear to be influenced by the prevailing experimental conditions...
  16. ncbi A mutation affecting dihydropyridine-sensitive current levels and activation kinetics in Drosophila muscle and mammalian heart calcium channels
    D Ren
    Department of Biochemical Pharmacology, State University of New York at Buffalo, Buffalo, New York 14260 1200, USA
    J Neurosci 18:2335-41. 1998
    ..Amino acid substitutions at this Cys position in the cardiac alpha1 subunit show that the size of the side chain, rather than its ability to form disulfide bonds, affects channel activation...
  17. ncbi Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels
    J Yang
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, California 94305
    Nature 366:158-61. 1993
    ..Competition among Ca2+ ions for individual glutamates, together with repulsive ion-ion electrostatic interaction, may help achieve rapid flux rates through the channel...
  18. ncbi Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit
    M Pragnell
    Howard Hughes Medical Institute, Department of Physiology, University of Iowa College of Medicine, Iowa City 52242
    Nature 368:67-70. 1994
    ..Conservation of the beta-subunit binding motif in these functionally distinct calcium channels suggests a critical role for the I-II cytoplasmic linker of the alpha 1-subunit in channel modulation by the beta-subunit...
  19. ncbi Essential Ca(2+)-binding motif for Ca(2+)-sensitive inactivation of L-type Ca2+ channels
    M De Leon
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 270:1502-6. 1995
    ..Donation of the alpha 1C EF-hand region to the alpha 1E channel conferred the Ca(2+)-inactivating phenotype. These results strongly suggest that Ca2+ binding to the alpha 1C subunit initiates Ca2+ inactivation...
  20. ncbi Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel
    A Mikami
    Department of Medical Chemistry Kyoto University Faculty of Medicine, Japan
    Nature 340:230-3. 1989
    ..Furthermore, higher calcium-channel activity is observed when mRNA specific for the polypeptide of relative molecular mass approximately 140,000 (alpha 2-subunit) associated with skeletal muscle DHP receptor is co-injected...
  21. ncbi Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes
    E Perez-Reyes
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 265:20430-6. 1990
    ..These results demonstrate that calcium channel diversity is created by both the expression of distinct genes and the alternate splicing of these genes...
  22. ncbi Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung
    M Biel
    Medizinische Biochemie, Universitat des Saarlandes, Homburg Saar, FRG
    FEBS Lett 269:409-12. 1990
    ..Synthetic RNA derived from this cDNA induces the formation of a functional CaCB-sensitive high voltage activated calcium channel in Xenopus oocytes...
  23. ncbi Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels
    M Biel
    Institut für Medizinische Biochemie, Medizinische Fakultat, Universitat des Saarlandes, Homburg, Federal Republic of Germany
    Eur J Biochem 200:81-8. 1991
    ..cloning of the cDNA for the alpha 1 subunit of L-type calcium channels revealed that at least two genes (CaCh1 and CaCh2) exist which give rise to several splice variants...