PEDVgp2

Summary

Gene Symbol: PEDVgp2
Description: spike protein
Species: Porcine epidemic diarrhea virus

Top Publications

  1. doi Immunogenicity and protective efficacy of recombinant S1 domain of the porcine epidemic diarrhea virus spike protein
    Jongsuk Oh
    Animal Virology Laboratory, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 702 701, Republic of Korea
    Arch Virol 159:2977-87. 2014
  2. pmc Genetic variation analyses of porcine epidemic diarrhea virus isolated in mid-eastern China from 2011 to 2013
    Pan Deng Zhao
    Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Can J Vet Res 79:8-15. 2015
  3. pmc A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion
    Wentao Li
    Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People s Republic of China
    J Virol 89:8077-81. 2015
  4. doi New porcine epidemic diarrhoea virus variant with a large deletion in the spike gene identified in domestic pigs
    Tsuneyuki Masuda
    Kurayoshi Livestock Hygiene Service Center, Kurayoshi, Tottori, Japan
    Arch Virol 160:2565-8. 2015
  5. pmc Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains
    Feng Deng
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
    Viruses 8:55. 2016
  6. doi Mutation in the cytoplasmic retrieval signal of porcine epidemic diarrhea virus spike (S) protein is responsible for enhanced fusion activity
    Kazuya Shirato
    Laboratory of Acute Respiratory Viral Diseases and Cytokines, Department of Virology III, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    Virus Res 161:188-93. 2011
  7. ncbi Sequence analysis of the porcine epidemic diarrhea virus genome between the nucleocapsid and spike protein genes reveals a polymorphic ORF
    M Duarte
    I N R A Unité de Virologie et Immunologie Moléculaires, CR de Jouy en Josas, France
    Virology 198:466-76. 1994
  8. ncbi Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus
    A Bridgen
    Institut fur Virologie, Veterinärmedizinische Fakultät, Universitat Zurich, Switzerland
    J Gen Virol 74:1795-804. 1993
  9. ncbi PEDV leader sequence and junction sites
    K Tobler
    Institute of Virology, Vet Med Faculty, University of Zurich, Switzerland
    Adv Exp Med Biol 380:541-2. 1995
  10. ncbi Further analysis of the genome of porcine epidemic diarrhoea virus
    A Bridgen
    Institute of Virology, University of Zurich, Switzerland
    Adv Exp Med Biol 440:781-6. 1998

Scientific Experts

  • Bongkyun Park
  • Seong Jun Park
  • Deu John M Cruz
  • Feng Deng
  • Qigai He
  • Tsuneyuki Masuda
  • Pan Deng Zhao
  • Wentao Li
  • Jongsuk Oh
  • Ayako Miyazaki
  • Jung Eun Park
  • Kazuya Shirato
  • Hyun Jin Shin
  • A Bridgen
  • K Tobler
  • Dae Sub Song
  • M Ackermann
  • R Kocherhans
  • Xiaoli Zhong
  • Qianqian Liu
  • Muhammad Tariq Navid
  • Shaobo Xiao
  • Guiqing Peng
  • Chunyun Wan
  • Zhen F Fu
  • Gang Ye
  • Youwen Li
  • Oliver Wicht
  • Yanpen Dong
  • Xiaoli Shi
  • Hiroshi Yamasato
  • Juan Bai
  • Seiichi Ohashi
  • Tohru Suzuki
  • Chen Tan
  • Peter J M Rottier
  • Osamu Takahashi
  • Frank J M van Kuppeveld
  • Berend Jan Bosch
  • Satoshi Murakami
  • Ping Jiang
  • Yufeng Li
  • Hwan Won Choi
  • Kyung Won Lee
  • Changhee Lee
  • Makoto Ujike
  • Natsumi Takeyama
  • Madoka Maejima
  • Hidetoshi Ikeda
  • Shutoku Matsuyama
  • Fumihiro Taguchi
  • Chul Joong Kim
  • Hyoung Joon Moon
  • Chul Seung Lee
  • Gun Woo Ha
  • Bo Kyu Kang
  • Jeong Sun Yang
  • M Duarte
  • A Carvajal
  • H Laude
  • D Rasschaert

Detail Information

Publications15

  1. doi Immunogenicity and protective efficacy of recombinant S1 domain of the porcine epidemic diarrhea virus spike protein
    Jongsuk Oh
    Animal Virology Laboratory, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 702 701, Republic of Korea
    Arch Virol 159:2977-87. 2014
    ..The results showed that vaccination with S1 protein efficiently protected neonatal piglets against PEDV. Our data suggest that the recombinant S1 protein shows potential as an effective and safe subunit vaccine for PED prevention...
  2. pmc Genetic variation analyses of porcine epidemic diarrhea virus isolated in mid-eastern China from 2011 to 2013
    Pan Deng Zhao
    Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Can J Vet Res 79:8-15. 2015
    ..6% to 100% in deduced amino acid sequence to each other. Our results indicate that the variant PEDV strain spread wildly in mid-eastern China. This will be useful to take into consideration in the control and prevention of this disease. ..
  3. pmc A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion
    Wentao Li
    Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People s Republic of China
    J Virol 89:8077-81. 2015
    ..PEDV-SFCS exhibited trypsin-independent cell-cell fusion and was able to replicate in culture cells independently of trypsin, though to low titer...
  4. doi New porcine epidemic diarrhoea virus variant with a large deletion in the spike gene identified in domestic pigs
    Tsuneyuki Masuda
    Kurayoshi Livestock Hygiene Service Center, Kurayoshi, Tottori, Japan
    Arch Virol 160:2565-8. 2015
    ..Moreover, the Tottori2 PEDV strain was successfully isolated in Vero cells by serial passage. ..
  5. pmc Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains
    Feng Deng
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
    Viruses 8:55. 2016
    ..Understanding the differences in receptor binding between the prototype and the variant strains may provide insight into PEDV pathogenesis. ..
  6. doi Mutation in the cytoplasmic retrieval signal of porcine epidemic diarrhea virus spike (S) protein is responsible for enhanced fusion activity
    Kazuya Shirato
    Laboratory of Acute Respiratory Viral Diseases and Cytokines, Department of Virology III, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama, Tokyo 208 0011, Japan
    Virus Res 161:188-93. 2011
    ..Loss of this motif could allow for the efficient transfer of S proteins from ERGIC onto the cell surface and subsequent increased fusion activity...
  7. ncbi Sequence analysis of the porcine epidemic diarrhea virus genome between the nucleocapsid and spike protein genes reveals a polymorphic ORF
    M Duarte
    I N R A Unité de Virologie et Immunologie Moléculaires, CR de Jouy en Josas, France
    Virology 198:466-76. 1994
    ..The function of these polypeptides is not known, but the predicted products of the PEDV ORF3 and related ORFs share features suggestive of a membrane-associated protein...
  8. ncbi Sequence determination of the nucleocapsid protein gene of the porcine epidemic diarrhoea virus confirms that this virus is a coronavirus related to human coronavirus 229E and porcine transmissible gastroenteritis virus
    A Bridgen
    Institut fur Virologie, Veterinärmedizinische Fakultät, Universitat Zurich, Switzerland
    J Gen Virol 74:1795-804. 1993
    ..Several RNA motifs typical of coronaviruses were also observed. These results confirm the earlier provisional classification of PEDV as a coronavirus...
  9. ncbi PEDV leader sequence and junction sites
    K Tobler
    Institute of Virology, Vet Med Faculty, University of Zurich, Switzerland
    Adv Exp Med Biol 380:541-2. 1995
  10. ncbi Further analysis of the genome of porcine epidemic diarrhoea virus
    A Bridgen
    Institute of Virology, University of Zurich, Switzerland
    Adv Exp Med Biol 440:781-6. 1998
    ....
  11. ncbi Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence
    R Kocherhans
    Virologisches Institut der Veterinär Medizinischen Fakultät, Universitat Zurich
    Virus Genes 23:137-44. 2001
    ..These results thus confirm and extend the findings from sequence analysis of the structural genes of PEDV...
  12. ncbi Cloning and further sequence analysis of the spike gene of attenuated porcine epidemic diarrhea virus DR13
    Seong Jun Park
    Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine, Seoul National University, Gwanak Gu, Seoul, 151 742, Korea
    Virus Genes 35:55-64. 2007
    ..Phylogenetic analysis suggested that attenuated PEDV DR13 is closely related to CV777, Br1/87, JS-2004-2 and parent DR13, rather than to Spk1 and Chinju99 and is especially close to the Chinese PEDV strain JS-2004-2...
  13. ncbi Sequence analysis of the partial spike glycoprotein gene of porcine epidemic diarrhea viruses isolated in Korea
    Seong Jun Park
    Department of Veterinary Medicine Virology Lab, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Gwanak Gu, Seoul 151 742, Korea
    Virus Genes 35:321-32. 2007
    ....
  14. ncbi The GPRLQPY motif located at the carboxy-terminal of the spike protein induces antibodies that neutralize Porcine epidemic diarrhea virus
    Deu John M Cruz
    College of Veterinary Medicine, Chungnam National University, Daejeon 305 764, Republic of Korea
    Virus Res 132:192-6. 2008
    ..In addition, antiS-CT24 antibodies exhibited neutralizing activities against KPEDV-9 in focus reduction neutralization tests suggesting that the GPRLQPY motif induces neutralizing antibodies against PEDV...
  15. doi Receptor-bound porcine epidemic diarrhea virus spike protein cleaved by trypsin induces membrane fusion
    Jung Eun Park
    Laboratory of Infectious Diseases, Animal Hospital, College of Veterinary Medicine, Chungnam National University, 220 Gungdong, Yuseong, Daejeon 305 764, Korea
    Arch Virol 156:1749-56. 2011
    ..These findings strongly suggest that the PEDV S protein may undergo a conformational change after receptor binding and cleavage by exogenous trypsin, which induces membrane fusion...