LIF

Summary

Gene Symbol: LIF
Description: LIF, interleukin 6 family cytokine
Alias: leukemia inhibitory factor, leukemia inhibitory factor (cholinergic differentiation factor)
Species: pig

Top Publications

  1. doi Leukemia inhibitory factor promotes porcine oocyte maturation and is accompanied by activation of signal transducer and activator of transcription 3
    Thanh Quang Dang-Nguyen
    Animal Breeding and Reproduction Division, NARO Institute of Livestock and Grassland Science, Tsukuba, Ibaraki, Japan
    Mol Reprod Dev 81:230-9. 2014
  2. pmc Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos
    Ye Yuan
    Division of Animal Sciences and Bond Life Sciences Center University of Missouri Columbia, MO USA
    Cell Cycle 13:1265-76. 2014
  3. doi Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway
    Alison J Thomson
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom
    Cell Reprogram 14:112-22. 2012
  4. doi Regulation of expression and role of leukemia inhibitory factor and interleukin-6 in the uterus of early pregnant pigs
    A Blitek
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
    Theriogenology 78:951-64. 2012
  5. ncbi Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein
    T A Willson
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Eur J Biochem 204:21-30. 1992
  6. ncbi Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig
    G Rettenberger
    Department of Medical Genetics, University of Ulm, D 89069 Ulm, Germany
    Mamm Genome 7:275-9. 1996
  7. ncbi Complex conserved organization of the mammalian leukemia inhibitory factor gene: regulated expression of intracellular and extracellular cytokines
    B P Haines
    Department of Biochemistry, University of Adelaide, Australia
    J Immunol 162:4637-46. 1999
  8. ncbi Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF
    A Spötter
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, D 30559 Hannover, Germany
    Cytogenet Cell Genet 93:87-90. 2001
  9. ncbi Evidence of a new leukemia inhibitory factor-associated genetic marker for litter size in a synthetic pig line
    A Spötter
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17 p, 30559 Hannover, Germany
    J Anim Sci 83:2264-70. 2005
  10. doi Leukemia inhibitory factor is upregulated in coronary arteries of Ossabaw miniature swine after stent placement
    Pamela G Lloyd
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Coron Artery Dis 19:217-26. 2008

Scientific Experts

  • A Blitek
  • A Spötter
  • Thanh Quang Dang-Nguyen
  • Ye Yuan
  • Alison J Thomson
  • H C Lin
  • Pamela G Lloyd
  • R Michael Roberts
  • Kevin D Wells
  • Takashi Nagai
  • Kwang Wook Park
  • Szilard Bodo
  • Kazuhiro Kikuchi
  • Tamas Somfai
  • Seiki Haraguchi
  • Kiho Lee
  • Lee D Spate
  • Randall S Prather
  • Linda Sutherland
  • Alan L Archibald
  • Tom C Freeman
  • Hadrien Pierart
  • Tom Burdon
  • Chiara Sartori
  • Richard Talbot
  • Alison Downing
  • Edward Mountjoy
  • Stephen Meek
  • Alexandra Bogerman
  • Helen Murray
  • C Bruce A Whitelaw
  • J L Fu
  • X F Wang
  • L J Kong
  • G F Liu
  • A G Wang
  • Michael Sturek
  • Eric A Mokelke
  • Alexander J Sheehy
  • Jason M Edwards
  • B P Haines
  • G Rettenberger
  • T A Pelton
  • R Forrest
  • P D Rathjen
  • R B Voyle
  • A L Archibald
  • J Bruch
  • R Fries
  • H Hameister
  • T A Willson
  • N M Gough
  • D Metcalf

Detail Information

Publications12

  1. doi Leukemia inhibitory factor promotes porcine oocyte maturation and is accompanied by activation of signal transducer and activator of transcription 3
    Thanh Quang Dang-Nguyen
    Animal Breeding and Reproduction Division, NARO Institute of Livestock and Grassland Science, Tsukuba, Ibaraki, Japan
    Mol Reprod Dev 81:230-9. 2014
    We produced recombinant porcine leukemia inhibitory factor (pLIF) and examined its effect on in vitro maturation (IVM) of porcine oocytes and their developmental competence after in vitro fertilization...
  2. pmc Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos
    Ye Yuan
    Division of Animal Sciences and Bond Life Sciences Center University of Missouri Columbia, MO USA
    Cell Cycle 13:1265-76. 2014
    ..Together, these data provide at least a partial explanation for the almost complete failure to produce cloned piglets from piPSC...
  3. doi Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway
    Alison J Thomson
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, United Kingdom
    Cell Reprogram 14:112-22. 2012
    ..Mouse embryonic stem cells (ESCs) respond to leukemia inhibitory factor (LIF) and bone morphogenetic protein (BMP)-mediated activity, whereas human ESCs depend upon Fibroblast ..
  4. doi Regulation of expression and role of leukemia inhibitory factor and interleukin-6 in the uterus of early pregnant pigs
    A Blitek
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
    Theriogenology 78:951-64. 2012
    ..We examined: (1) the expression profiles of leukemia inhibitory factor (LIF) and interleukin (IL)-6 mRNA and their protein content in the endometrium of cyclic and pregnant ..
  5. ncbi Cross-species comparison of the sequence of the leukaemia inhibitory factor gene and its protein
    T A Willson
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Eur J Biochem 204:21-30. 1992
    Leukaemia inhibitory factor (LIF) is a pleiotropic growth factor active in diverse cell systems in both the adult and the embryo. The LIF gene from a number of mammalian species is highly conserved...
  6. ncbi Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig
    G Rettenberger
    Department of Medical Genetics, University of Ulm, D 89069 Ulm, Germany
    Mamm Genome 7:275-9. 1996
    Nineteen so-called type I-loci, including ACO2, ADRA2, CAST, CCK, CHAT, IGKC, IGLV, IL4, IL6, INHA, LIF, MX1, PTH, RBP2, TCRA, TCRB, TGFB2, TGFB3, and UOX have been mapped in the pig with an informative somatic cell hybrid panel...
  7. ncbi Complex conserved organization of the mammalian leukemia inhibitory factor gene: regulated expression of intracellular and extracellular cytokines
    B P Haines
    Department of Biochemistry, University of Adelaide, Australia
    J Immunol 162:4637-46. 1999
    b>Leukemia inhibitory factor (LIF) is a member of the IL-6 family of pleiotropic cytokines, which are extensively involved in modulating hematopoiesis and immunity...
  8. ncbi Molecular characterization and chromosome assignment of the porcine gene for leukemia inhibitory factor LIF
    A Spötter
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, D 30559 Hannover, Germany
    Cytogenet Cell Genet 93:87-90. 2001
    b>Leukemia inhibitory factor (LIF) is a pleiotropic cytokine involved in early conceptus development in pig. We isolated a PAC clone containing the porcine LIF gene and determined the complete DNA sequence of the gene, which spans about 6...
  9. ncbi Evidence of a new leukemia inhibitory factor-associated genetic marker for litter size in a synthetic pig line
    A Spötter
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17 p, 30559 Hannover, Germany
    J Anim Sci 83:2264-70. 2005
    The association of a diallelic polymorphism in the leukemia inhibitory factor (LIF) gene with reproductive, growth, and carcass traits was studied in a German synthetic pig line...
  10. doi Leukemia inhibitory factor is upregulated in coronary arteries of Ossabaw miniature swine after stent placement
    Pamela G Lloyd
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Coron Artery Dis 19:217-26. 2008
    b>Leukemia inhibitory factor (LIF), an IL-6 class cytokine, is reported to be antiatherosclerotic. Thus, we hypothesized that LIF expression might be altered during in-stent neointimal hyperplasia...
  11. doi Effect of polymorphisms in the genes for LIF and RBP4 on litter size in two German pig lines
    A Spötter
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany
    Reprod Domest Anim 44:100-5. 2009
    The association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4) with number of piglets born alive (NBA) in two German pig lines was studied...
  12. doi Effect of polymorphism in the leukemia inhibitory factor gene on litter size in Large White pigs
    H C Lin
    College of Animal Science and Technology and Key Laboratory for Animal Genetics and Breeding of Ministry of Agriculture, China Agricultural University, Beijing, China
    Mol Biol Rep 36:1833-8. 2009
    DNA polymorphism of the porcine leukemia inhibitory factory (LIF) was investigated and used to study the effects on litter size in Large White pigs...