GJA1

Summary

Gene Symbol: GJA1
Description: gap junction protein alpha 1
Alias: CX43, gap junction alpha-1 protein, connexin 43, gap junction protein, alpha 1, 43kDa
Species: pig

Top Publications

  1. ncbi Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation
    Junko Kamei
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 312:380-7. 2003
  2. doi Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells
    Christos E Chadjichristos
    Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland
    Circ Res 102:653-60. 2008
  3. doi Regulation of gap junctions in porcine cumulus-oocyte complexes: contributions of granulosa cell contact, gonadotropins, and lipid rafts
    Maxime Sasseville'
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Universite Laval, Quebec, Canada
    Mol Endocrinol 23:700-10. 2009
  4. doi Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 46:1050-60. 2011
  5. pmc Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate
    Anna Hejmej
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30 387 Krakow, Poland
    Biomed Res Int 2013:407678. 2013
  6. pmc The dynamics of connexin expression, degradation and localisation are regulated by gonadotropins during the early stages of in vitro maturation of swine oocytes
    Nicolas Santiquet
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, FSAA, Universite Laval, Quebec, Quebec, Canada
    PLoS ONE 8:e68456. 2013
  7. ncbi Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning
    Kerstin Boengler
    Institut fur Pathophysiologie, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Cardiovasc Res 67:234-44. 2005
  8. doi Real-time proliferation of porcine cumulus cells is related to the protein levels and cellular distribution of Cdk4 and Cx43
    Bartosz Kempisty
    Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland
    Theriogenology 80:411-20. 2013
  9. doi Light- and transmission-electron-microscopic investigations on distribution of CD44, connexin 43 and actin cytoskeleton during the foreign body reaction to a nanoparticular hydroxyapatite in mini-pigs
    Sabine Wenisch
    Institute of Veterinary Anatomy, University of Giessen, Germany
    Acta Biomater 8:2807-14. 2012
  10. ncbi Gap junctions and cell polarity: connexin32 and connexin43 expressed in polarized thyroid epithelial cells assemble into separate gap junctions, which are located in distinct regions of the lateral plasma membrane domain
    A Guerrier
    Institut National de la Santé et de la Recherche Médicale U369, Faculte de Medecine Alexis Carrel, Lyon, France
    J Cell Sci 108:2609-17. 1995

Scientific Experts

  • Olympia Bikou
  • J Karasinski
  • I Kopera
  • Anna Hejmej
  • Bartosz Kempisty
  • Nicolas Santiquet
  • Ian D Greener
  • Sabine Wenisch
  • François J Richard
  • Yu tong Cheng
  • M Duda
  • A Hejmej
  • B Bilinska
  • M Slomczynska
  • K Knapczyk-Stwora
  • M Durlej
  • Hong zhen Liu
  • Maxime Sasseville'
  • Christos E Chadjichristos
  • Kerstin Boengler
  • Marcel A G van der Heyden
  • Junko Kamei
  • Maciej Zabel
  • Hanna Piotrowska
  • Ewelina Górowska
  • Katarzyna Chojnacka
  • Paweł Antosik
  • Klaus P Brüssow
  • Sylwia Ciesiółka
  • Małgorzata Kotula-Balak
  • Dorota Bukowska
  • Justyna Zając
  • Barbara Bilinska
  • Agnieszka Ziółkowska
  • Michał Nowicki
  • Marta Zarzycka
  • Piotr Zawierucha
  • Claude Robert
  • Jedrzej M Jaskowski
  • Olaf Kilian
  • Tetsuo Sasano
  • Christian Heiss
  • Volker Alt
  • E Ada Cavalcanti-Adam
  • Stefan Arnhold
  • Tomonori Igarashi
  • Reinhard Schnettler
  • Xiaoping Wan
  • Eva Tryankowski
  • J Kevin Donahue
  • Oksana Raabe
  • Maria Strom
  • David S Rosenbaum
  • Sheng Kang
  • Hai yan Qian
  • Hai tao Zhang
  • Yue jin Yang
  • Jing lin Zhao
  • Xiang Dong Li
  • M Koziorowski
  • Jing Wang
  • Guo Ying Su
  • Jing Quan Zhong
  • Yun Zhang
  • Jing Sha Li
  • Marie Claude Gagnon
  • Robert B Gilchrist
  • Robert Sullivan
  • Christine Guillemette
  • Isabelle Roth
  • Jean Paul Derouette
  • Anne C Brisset
  • Esther Sutter
  • Marie Luce Bochaton-Piallat
  • Brenda R Kwak
  • Sandrine Morel
  • Rainer Schulz
  • Marisol Ruiz-Meana
  • Giuliano Dodoni
  • Antonio Rodriguez-Sinovas
  • Carmen Lopez-Iglesias
  • David Garcia-Dorado
  • Fabio Di Lisa
  • Ina Konietzka
  • Petra Gres
  • Gerd Heusch
  • Alberto Cabestrero
  • Marleen van Eijk
  • Ronald Wilders
  • Tobias Opthof

Detail Information

Publications19

  1. ncbi Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which cell adhesion molecules regulate cell proliferation
    Junko Kamei
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 312:380-7. 2003
    ..We conclude, therefore, that two major components of cell-cell interaction synergistically regulate cell cycle progression in HEK293 cells by regulating p21 expression in a beta-catenin/TCF-dependent manner...
  2. doi Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells
    Christos E Chadjichristos
    Division of Cardiology, Geneva University Hospitals, Faculty of Medicine, University of Geneva, Switzerland
    Circ Res 102:653-60. 2008
    ..Cx40 was highly expressed in normal media of porcine coronary artery in vivo, whereas Cx43 was barely detectable...
  3. doi Regulation of gap junctions in porcine cumulus-oocyte complexes: contributions of granulosa cell contact, gonadotropins, and lipid rafts
    Maxime Sasseville'
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, Universite Laval, Quebec, Canada
    Mol Endocrinol 23:700-10. 2009
    ..However, little is known about the regulation of connexin 43 (Cx43)-based gap-junction channels in cumulus-oocyte complexes (COCs) during in vitro maturation...
  4. doi Differential expression of connexin 43 in adult pig testes during normal spermatogenic cycle and after flutamide treatment
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 46:1050-60. 2011
    ..androgen withdrawal caused by prenatal (GD20, GD80) or neonatal (PD2) exposure to an anti-androgen flutamide alters Cx43 gene expression and may induce delayed effects on morphology and function of adult pig testes...
  5. pmc Androgen signaling disruption during fetal and postnatal development affects androgen receptor and connexin 43 expression and distribution in adult boar prostate
    Anna Hejmej
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Gronostajowa 9, 30 387 Krakow, Poland
    Biomed Res Int 2013:407678. 2013
    ..the androgen signaling during specific periods of development in the regulation of androgen receptor (AR) and connexin 43 (Cx43) in adult prostate...
  6. pmc The dynamics of connexin expression, degradation and localisation are regulated by gonadotropins during the early stages of in vitro maturation of swine oocytes
    Nicolas Santiquet
    Centre de Recherche en Biologie de la Reproduction, Departement des Sciences Animales, FSAA, Universite Laval, Quebec, Quebec, Canada
    PLoS ONE 8:e68456. 2013
    ..b>Cx43, Cx45 and Cx60 were identified as the main connexins expressed in swine COC...
  7. ncbi Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning
    Kerstin Boengler
    Institut fur Pathophysiologie, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Hufelandstr 55, 45122 Essen, Germany
    Cardiovasc Res 67:234-44. 2005
    b>Connexin 43 (Cx43) is involved in infarct size reduction by ischemic preconditioning (IP); the underlying mechanism of protection, however, is unknown...
  8. doi Real-time proliferation of porcine cumulus cells is related to the protein levels and cellular distribution of Cdk4 and Cx43
    Bartosz Kempisty
    Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland
    Theriogenology 80:411-20. 2013
    ..The aim of this study was (i) to investigate maturation markers, such as Cx43 and Cdk4 protein levels, and (ii) to analyze the distribution of these two proteins in CCs cultured for 44, 88, 132,..
  9. doi Light- and transmission-electron-microscopic investigations on distribution of CD44, connexin 43 and actin cytoskeleton during the foreign body reaction to a nanoparticular hydroxyapatite in mini-pigs
    Sabine Wenisch
    Institute of Veterinary Anatomy, University of Giessen, Germany
    Acta Biomater 8:2807-14. 2012
    ..The molecular mechanisms underlying the formation of FBGCs are still largely obscure. Here we propose connexin 43 (cx43) and CD44 as candidate molecules involved in the fusion process...
  10. ncbi Gap junctions and cell polarity: connexin32 and connexin43 expressed in polarized thyroid epithelial cells assemble into separate gap junctions, which are located in distinct regions of the lateral plasma membrane domain
    A Guerrier
    Institut National de la Santé et de la Recherche Médicale U369, Faculte de Medecine Alexis Carrel, Lyon, France
    J Cell Sci 108:2609-17. 1995
    ..Increasing concentrations of this detergent from 0.12% to 0.42% caused a progressive solubilization of connexin43 while connexin32 remained membrane-bound.(ABSTRACT TRUNCATED AT 250 WORDS)..
  11. ncbi [Changes in myocardial connexin 43 during ventricular fibrillation]
    Hong zhen Liu
    Department of Cardiology, Qilu Hospital Affiliated to Shandong University, Jinan 250012, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 22:595-8. 2010
    To observe changes in connexin 43 (Cx43) after ventricular fibrillation (VF) and the effects of rotigaptide (ZP123) on Cx43.
  12. pmc Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction
    Ian D Greener
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio 44109, USA
    J Am Coll Cardiol 60:1103-10. 2012
    The aim of this study was to evaluate the links between connexin43 (Cx43) expression, myocardial conduction velocity, and ventricular tachycardia in a model of healed myocardial infarction.
  13. doi No-reflow disrupts the expression and distribution of connexin 43 in a swine model
    Yu tong Cheng
    Department of Cardiology, Fuwai Hospital and Cardiovascular Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China
    Microvasc Res 82:404-9. 2011
    Ischemia and ischemia/reperfusion can dephosphorylate and redistribute connexin 43 (Cx43). But it is unknown whether no-reflow phenomenon has an effect on the expression and distribution of Cx43 after acute infarction and reperfusion.
  14. doi Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model
    Olympia Bikou
    Department of Cardiology, Medical University Hospital, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    Cardiovasc Res 92:218-25. 2011
    ..We hypothesized that AF suppresses expression of the gap junction protein connexin (Cx) 43 and that Cx43 gene transfer to both atria would prevent persistent AF...
  15. pmc Effects of pre- and postnatal exposure to flutamide on connexin 43 expression in testes and ovaries of prepubertal pigs
    I Kopera
    Department of Endocrinology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Eur J Histochem 54:e15. 2010
    The aim of this study was to show whether the connexin43 (Cx43) expression in gonads is affected by an anti-androgen action...
  16. doi Changes of connexin43 expression in non-pregnant porcine myometrium correlate with progesterone concentration during oestrous cycle
    J Karasinski
    Department of Cytology and Histology, Institute of Zoology, Jagiellonian University, Krakow, Poland
    Reprod Domest Anim 45:959-66. 2010
    Connexin43 (Cx43) is a major protein of myometrial gap junctions. The number of Cx43 gap junctions increase dramatically with the onset of labour in association with development of synchronized uterine contractions...
  17. ncbi Connexin43 orthologues in vertebrates: phylogeny from fish to man
    Marcel A G van der Heyden
    Department of Medical Physiology, University Medical Center Utrecht, PO Box 85060, 3508 AB, The Netherlands
    Dev Genes Evol 214:261-6. 2004
    The gap junction protein connexin43 (Cx43) is widely expressed in all vertebrate species; however, in ventricular myocardium, Cx43 expression is restricted to mammalian species only, where it provides the molecular correlate for both ..
  18. ncbi Porcine aortic endothelial gap junctions: identification and permeation by caged InsP3
    T D Carter
    National Institute for Medical Research, London, UK
    J Cell Sci 109:1765-73. 1996
    ..These results show that primary cultures of porcine aortic endothelial cells express connexin 37 and 43, and provide strong evidence that the second messenger molecule InsP3 can permeate porcine endothelial gap junctions...