dipeptidyl peptidase IV

Summary

Gene Symbol: dipeptidyl peptidase IV
Description: dipeptidyl peptidase 4
Alias: ADABP, CD26, DPPIV, dipeptidyl peptidase 4, DPP IV, T-cell activation antigen CD26, dipeptidyl peptidase IV, dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2), dipeptidyl-peptidase iv
Species: pig

Top Publications

  1. ncbi Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig
    A Plamboeck
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 48:1882-90. 2005
  2. doi Comparison of the susceptibility of porcine and human dipeptidyl-peptidase IV to inhibition by protein-derived peptides
    Isabelle M E Lacroix
    The University of British Columbia, Faculty of Land and Food Systems, Food Nutrition and Health program, 2205 East Mall, Vancouver, BC, Canada V6T 1Z4
    Peptides 69:19-25. 2015
  3. ncbi N-terminal amino-acid sequence of pig kidney dipeptidyl peptidase IV solubilized by autolysis
    R Seidl
    Max Planck Institut fur Biochemie, Martinsried bei Munchen
    Biol Chem Hoppe Seyler 372:213-4. 1991
  4. ncbi Assignment of the dipeptidylpeptidase IV (DPP4) gene to pig chromosome 15q21
    P D Thomsen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Mamm Genome 4:604-7. 1993
  5. pmc The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
    Michael Engel
    Max Planck Institut fur Biochemie, Abt Strukturforschung, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 100:5063-8. 2003
  6. ncbi Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme
    Joachim Bär
    Probiodrug AG, Department of Enzymology, D 06120 Halle, Germany
    Biol Chem 384:1553-63. 2003
  7. ncbi Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR
    Leona Wagner
    Department of Molecular Biology, Probiodrug AG, Weinbergweg 22, 06120 Halle Saale, Germany
    Adv Exp Med Biol 575:109-16. 2006
  8. doi Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV
    Isel Pascual
    Centro de Estudios de Proteínas, Facultad de Biologia, Universidad de La Habana, Calle 25 No 455, Vedado, La Habana 10400, Cuba
    Int J Biochem Cell Biol 43:363-71. 2011

Scientific Experts

  • Isel Pascual
  • Leona Wagner
  • Isabelle M E Lacroix
  • Hans Ulrich Demuth
  • Torsten Hoffmann
  • A Plamboeck
  • Michael Wermann
  • Joachim Bär
  • Michael Engel
  • Eunice C Y Li-Chan
  • Jens Ulrich Rahfeld
  • J J Holst
  • R D Carr
  • C F Deacon
  • Hans Brandstetter
  • Jörg Stork
  • Wolfram Bode
  • Bernd Gerhartz
  • Ulrich Heiser
  • Reiner Kiefersauer
  • Anja Weber
  • Robert Huber
  • Susanne Aust
  • P D Thomsen
  • O Noren
  • L Marklund
  • L Andersson
  • H Sjostrom
  • H Qvist
  • R Seidl
  • K Mann
  • W Schafer

Detail Information

Publications8

  1. ncbi Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig
    A Plamboeck
    Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 48:1882-90. 2005
    ..b>Dipeptidyl peptidase IV (DPP-IV) is established as the primary inactivating enzyme, but the roles of other enzymes remain unclear.
  2. doi Comparison of the susceptibility of porcine and human dipeptidyl-peptidase IV to inhibition by protein-derived peptides
    Isabelle M E Lacroix
    The University of British Columbia, Faculty of Land and Food Systems, Food Nutrition and Health program, 2205 East Mall, Vancouver, BC, Canada V6T 1Z4
    Peptides 69:19-25. 2015
    ..This study shows that porcine DPP-IV is generally inhibited with greater potency by protein-derived peptides than is the human enzyme...
  3. ncbi N-terminal amino-acid sequence of pig kidney dipeptidyl peptidase IV solubilized by autolysis
    R Seidl
    Max Planck Institut fur Biochemie, Martinsried bei Munchen
    Biol Chem Hoppe Seyler 372:213-4. 1991
    The N-terminal amino-acid sequence of the intrinsic membrane protein dipeptidyl peptidase IV (DP IV) was determined. The protein was isolated from pig kidney and solubilized by autolysis at pH 3.8...
  4. ncbi Assignment of the dipeptidylpeptidase IV (DPP4) gene to pig chromosome 15q21
    P D Thomsen
    Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    Mamm Genome 4:604-7. 1993
    ..The linkage analyses revealed significant evidence for linkage confirming the assignment of DPP4 to Chr 15...
  5. pmc The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
    Michael Engel
    Max Planck Institut fur Biochemie, Abt Strukturforschung, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 100:5063-8. 2003
    The membrane-bound glycoprotein dipeptidyl peptidase IV (DP IV, CD26) is a unique multifunctional protein, acting as receptor, binding and proteolytic molecule. We have determined the sequence and 1...
  6. ncbi Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme
    Joachim Bär
    Probiodrug AG, Department of Enzymology, D 06120 Halle, Germany
    Biol Chem 384:1553-63. 2003
    b>Dipeptidyl peptidase IV/CD26 (DP IV) is a multifunctional serine protease cleaving off dipeptides from the N-terminus of peptides...
  7. ncbi Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR
    Leona Wagner
    Department of Molecular Biology, Probiodrug AG, Weinbergweg 22, 06120 Halle Saale, Germany
    Adv Exp Med Biol 575:109-16. 2006
  8. doi Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV
    Isel Pascual
    Centro de Estudios de Proteínas, Facultad de Biologia, Universidad de La Habana, Calle 25 No 455, Vedado, La Habana 10400, Cuba
    Int J Biochem Cell Biol 43:363-71. 2011
    b>Dipeptidyl peptidase IV is an ectopeptidase with multiple physiological roles including the degradation of incretins, and a target of therapies for type 2 diabetes mellitus...