Rv3583c

Summary

Gene Symbol: Rv3583c
Description: RNA polymerase-binding transcription factor CarD
Species: Mycobacterium tuberculosis H37Rv

Top Publications

  1. pmc Structure of the Mtb CarD/RNAP β-lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD
    Gulcin Gulten
    Department of Chemistry, Texas A and M University, College Station, TX 77843, USA
    Structure 21:1859-69. 2013
  2. doi Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture
    Gundeep Kaur
    Structural Biology Laboratory, G N Ramachandran Protein Centre, CSIR Institute of Microbial Technology, Chandigarh, 160036, India
    Proteins 82:879-84. 2014
  3. doi Study of carD gene sequence in clinical isolates of Mycobacterium tuberculosis
    Hossein Sarmadian
    Arak University of Medical Sciences Tuberculosis and Pediatric Infectious Research Center Arak Iran
    Acta Microbiol Immunol Hung 61:1-10. 2014
  4. pmc CarD: a new RNA polymerase modulator in mycobacteria
    Christina L Stallings
    Department of Molecular Microbiology, Washington University, St Louis, MO, USA
    Transcription 2:15-8. 2011
  5. pmc CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence
    Christina L Stallings
    Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Cell 138:146-59. 2009
  6. doi CarD tricks and magic spots: mechanisms of stringent control in mycobacteria
    Lynn E Connolly
    Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Host Microbe 6:1-2. 2009

Scientific Experts

  • Christina L Stallings
  • Hossein Sarmadian
  • Gundeep Kaur
  • Gulcin Gulten
  • Lynn E Connolly
  • Krishan Gopal Thakur
  • Leonid P Titov
  • Fariba Rajabi
  • Azam Ahmadi
  • Razieh Nazari
  • Mana Shojapoor
  • Mohammad Reza Zolfaghari
  • Mina Pirayandeh
  • Dipak Dutta
  • Maryam Sadrnia
  • Mohammad Arjomandzadegan
  • James C Sacchettini
  • Jeffery S Cox

Detail Information

Publications6

  1. pmc Structure of the Mtb CarD/RNAP β-lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD
    Gulcin Gulten
    Department of Chemistry, Texas A and M University, College Station, TX 77843, USA
    Structure 21:1859-69. 2013
    ..Interestingly, the structure of the C-terminal domain, which is required for complete CarD function in vivo, represents a distinct DNA-binding fold...
  2. doi Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture
    Gundeep Kaur
    Structural Biology Laboratory, G N Ramachandran Protein Centre, CSIR Institute of Microbial Technology, Chandigarh, 160036, India
    Proteins 82:879-84. 2014
    ..The structure reveals dimeric state of CarD resulting from β-strand swapping between the N-terminal domains of each individual subunits. The structure provides crucial insights into the possible mode(s) of CarD/RNAP interactions...
  3. doi Study of carD gene sequence in clinical isolates of Mycobacterium tuberculosis
    Hossein Sarmadian
    Arak University of Medical Sciences Tuberculosis and Pediatric Infectious Research Center Arak Iran
    Acta Microbiol Immunol Hung 61:1-10. 2014
    ..In the other hand, a PCR detection method based on detection of carD gene was recommended for rapid detection in routine test. ..
  4. pmc CarD: a new RNA polymerase modulator in mycobacteria
    Christina L Stallings
    Department of Molecular Microbiology, Washington University, St Louis, MO, USA
    Transcription 2:15-8. 2011
    ..This article will review our present state of knowledge regarding CarD and compare the known functions of CarD with other RNAP binding proteins in E. coli, emphasizing how this information can guide future investigations...
  5. pmc CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence
    Christina L Stallings
    Immunology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Cell 138:146-59. 2009
    ..These findings highlight a distinct molecular mechanism for regulating rRNA transcription in mycobacteria that is critical for M. tuberculosis pathogenesis...
  6. doi CarD tricks and magic spots: mechanisms of stringent control in mycobacteria
    Lynn E Connolly
    Department of Microbiology and Immunology, Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Host Microbe 6:1-2. 2009
    ..coli. Now Stallings et al. report that Mycobacterium tuberculosis employs a different strategy involving the general transcription factor CarD for growth control and persistence in response to stresses encountered during infection...