dosT

Summary

Gene Symbol: dosT
Description: two component sensor histidine kinase DosT
Species: Mycobacterium tuberculosis H37Rv

Top Publications

  1. pmc Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis
    Marten H Vos
    Laboratory for Optics and Biosciences, CNRS Ecole Polytechnique, 91128 Palaiseau, France
    Biochemistry 51:159-66. 2012
  2. pmc DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis
    Eduardo Henrique Silva Sousa
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Protein Sci 16:1708-19. 2007
  3. pmc Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor
    Ashwani Kumar
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11568-73. 2007
  4. pmc Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
    Ryan W Honaker
    University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
    Infect Immun 77:3258-63. 2009
  5. pmc Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants
    Ashley Fallow
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Bacteriol 192:2228-38. 2010

Scientific Experts

  • Marten H Vos
  • Ashley Fallow
  • Ryan W Honaker
  • Ashwani Kumar
  • Eduardo Henrique Silva Sousa
  • Michael B Reed
  • Pilar Domenech
  • Martin I Voskuil
  • Rachel L Leistikow
  • Iona L Bartek
  • Jack R Lancaster
  • Adrie J C Steyn
  • Gonzalo Gonzalez
  • Marie Alda Gilles-Gonzalez
  • Jose C Toledo
  • Rakesh P Patel
  • Jason Robert Tuckerman

Detail Information

Publications5

  1. pmc Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis
    Marten H Vos
    Laboratory for Optics and Biosciences, CNRS Ecole Polytechnique, 91128 Palaiseau, France
    Biochemistry 51:159-66. 2012
    ..DosR can be activated by DosT and DosS, two histidine kinases with heme-containing sensor GAF domains, capable of diatomic ligand binding...
  2. pmc DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis
    Eduardo Henrique Silva Sousa
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Protein Sci 16:1708-19. 2007
    ..Two sensory kinases, DosT and DevS (also called DosS), control the activity of DevR...
  3. pmc Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor
    Ashwani Kumar
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11568-73. 2007
    ..The genetic response of Mtb to hypoxia and NO is controlled by the sensor kinases DosS and DosT and the response regulator DosR through activation of the dormancy/NO (Dos) regulon...
  4. pmc Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
    Ryan W Honaker
    University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
    Infect Immun 77:3258-63. 2009
    In Mycobacterium tuberculosis, the sensor kinases DosT and DosS activate the transcriptional regulator DosR, resulting in the induction of the DosR regulon, which is important for anaerobic survival and perhaps latent infection...
  5. pmc Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants
    Ashley Fallow
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Bacteriol 192:2228-38. 2010
    ..system comprising the transcription factor DosR and two possible cognate histidine sensor kinases, DosS and DosT. Through sequence analysis of a carefully selected set of isolates representing each of the major M...