Gene Symbol: devS
Description: two component sensor histidine kinase DevS
Species: Mycobacterium tuberculosis H37Rv
- DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesionsUma S Gautam
Divisions of 1 Bacteriology and Parasitology
Am J Respir Cell Mol Biol 52:708-16. 2015..DosR, in concert with sensor kinases DosS and DosT, regulates the response to hypoxia...
- Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosisMarten H Vos
Laboratory for Optics and Biosciences, CNRS Ecole Polytechnique, 91128 Palaiseau, France
Biochemistry 51:159-66. 2012..DosR can be activated by DosT and DosS, two histidine kinases with heme-containing sensor GAF domains, capable of diatomic ligand binding...
- Activation of ATP binding for the autophosphorylation of DosS, a Mycobacterium tuberculosis histidine kinase lacking an ATP lid motifHa Yeon Cho
School of Life Science and Biotechnology, Kyungpook National University, Daegu 702 701, South Korea
J Biol Chem 288:12437-47. 2013The sensor histidine kinases of Mycobacterium tuberculosis, DosS and DosT, are responsible for sensing hypoxic conditions and consist of sensor and kinase cores responsible for accepting signals and phosphorylation activity, respectively...
- A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haemSunita Sardiwal
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
J Mol Biol 353:929-36. 2005..The N-terminal input domain of the DosS sensor contains two GAF domains...
- DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosisEduardo Henrique Silva Sousa
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
Protein Sci 16:1708-19. 2007..Two sensory kinases, DosT and DevS (also called DosS), control the activity of DevR...
- Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensorAshwani Kumar
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 104:11568-73. 2007..The genetic response of Mtb to hypoxia and NO is controlled by the sensor kinases DosS and DosT and the response regulator DosR through activation of the dormancy/NO (Dos) regulon...
- Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genesSantosh Chauhan
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
J Bacteriol 190:4301-12. 2008The DevR-DevS two-component system of Mycobacterium tuberculosis mediates bacterial adaptation to hypoxia, a condition believed to be associated with the initiation and maintenance of dormant bacilli during latent tuberculosis...
- DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancyAlexandra Ioanoviciu
Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158 2517, USA
Biochemistry 48:5839-48. 2009b>DevS is one of the two sensing kinases responsible for DevR activation and the subsequent entry of Mycobacterium tuberculosis into dormancy. Full-length wild-type DevS forms a stable oxy-ferrous complex...
- Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancyRyan W Honaker
University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
Infect Immun 77:3258-63. 2009In Mycobacterium tuberculosis, the sensor kinases DosT and DosS activate the transcriptional regulator DosR, resulting in the induction of the DosR regulon, which is important for anaerobic survival and perhaps latent infection...
- Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutantsAshley Fallow
Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
J Bacteriol 192:2228-38. 2010..regulatory system comprising the transcription factor DosR and two possible cognate histidine sensor kinases, DosS and DosT. Through sequence analysis of a carefully selected set of isolates representing each of the major M...