devS

Summary

Gene Symbol: devS
Description: two component sensor histidine kinase DevS
Alias: dosS
Species: Mycobacterium tuberculosis H37Rv

Top Publications

  1. pmc DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesions
    Uma S Gautam
    Divisions of 1 Bacteriology and Parasitology
    Am J Respir Cell Mol Biol 52:708-16. 2015
  2. pmc Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis
    Marten H Vos
    Laboratory for Optics and Biosciences, CNRS Ecole Polytechnique, 91128 Palaiseau, France
    Biochemistry 51:159-66. 2012
  3. pmc Activation of ATP binding for the autophosphorylation of DosS, a Mycobacterium tuberculosis histidine kinase lacking an ATP lid motif
    Ha Yeon Cho
    School of Life Science and Biotechnology, Kyungpook National University, Daegu 702 701, South Korea
    J Biol Chem 288:12437-47. 2013
  4. ncbi A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem
    Sunita Sardiwal
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 353:929-36. 2005
  5. pmc DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis
    Eduardo Henrique Silva Sousa
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Protein Sci 16:1708-19. 2007
  6. pmc Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor
    Ashwani Kumar
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11568-73. 2007
  7. pmc Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genes
    Santosh Chauhan
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
    J Bacteriol 190:4301-12. 2008
  8. pmc DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy
    Alexandra Ioanoviciu
    Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158 2517, USA
    Biochemistry 48:5839-48. 2009
  9. pmc Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
    Ryan W Honaker
    University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
    Infect Immun 77:3258-63. 2009
  10. pmc Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants
    Ashley Fallow
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Bacteriol 192:2228-38. 2010

Scientific Experts

  • Marten H Vos
  • Uma S Gautam
  • Ha Yeon Cho
  • Ashley Fallow
  • Alexandra Ioanoviciu
  • Ryan W Honaker
  • Santosh Chauhan
  • Ashwani Kumar
  • Eduardo Henrique Silva Sousa
  • Sunita Sardiwal
  • David R Sherman
  • Jyothi Rengarajan
  • Tianhua Niu
  • Ryan S Kissee
  • Xavier Alvarez
  • Nadia A Golden
  • Amanda McGillivray
  • Peter J Didier
  • Deepak Kaushal
  • Cecily C Midkiff
  • Smriti Mehra
  • Beom Sik Kang
  • Eungbin Kim
  • Young Hoon Lee
  • Young Seuk Bae
  • Pilar Domenech
  • Michael B Reed
  • Rachel L Leistikow
  • Yergalem T Meharenna
  • Paul R Ortiz de Montellano
  • Iona L Bartek
  • Martin I Voskuil
  • Thomas L Poulos
  • Jaya Sivaswami Tyagi
  • Jason Robert Tuckerman
  • Jack R Lancaster
  • Rakesh P Patel
  • Jose C Toledo
  • Gonzalo Gonzalez
  • Marie Alda Gilles-Gonzalez
  • Adrie J C Steyn
  • Neil G Stoker
  • Farahnaz Movahedzadeh
  • Sharon L Kendall
  • Stuart C G Rison
  • Snezana Djordjevic

Detail Information

Publications10

  1. pmc DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesions
    Uma S Gautam
    Divisions of 1 Bacteriology and Parasitology
    Am J Respir Cell Mol Biol 52:708-16. 2015
    ..DosR, in concert with sensor kinases DosS and DosT, regulates the response to hypoxia...
  2. pmc Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis
    Marten H Vos
    Laboratory for Optics and Biosciences, CNRS Ecole Polytechnique, 91128 Palaiseau, France
    Biochemistry 51:159-66. 2012
    ..DosR can be activated by DosT and DosS, two histidine kinases with heme-containing sensor GAF domains, capable of diatomic ligand binding...
  3. pmc Activation of ATP binding for the autophosphorylation of DosS, a Mycobacterium tuberculosis histidine kinase lacking an ATP lid motif
    Ha Yeon Cho
    School of Life Science and Biotechnology, Kyungpook National University, Daegu 702 701, South Korea
    J Biol Chem 288:12437-47. 2013
    The sensor histidine kinases of Mycobacterium tuberculosis, DosS and DosT, are responsible for sensing hypoxic conditions and consist of sensor and kinase cores responsible for accepting signals and phosphorylation activity, respectively...
  4. ncbi A GAF domain in the hypoxia/NO-inducible Mycobacterium tuberculosis DosS protein binds haem
    Sunita Sardiwal
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Mol Biol 353:929-36. 2005
    ..The N-terminal input domain of the DosS sensor contains two GAF domains...
  5. pmc DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis
    Eduardo Henrique Silva Sousa
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Protein Sci 16:1708-19. 2007
    ..Two sensory kinases, DosT and DevS (also called DosS), control the activity of DevR...
  6. pmc Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor
    Ashwani Kumar
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:11568-73. 2007
    ..The genetic response of Mtb to hypoxia and NO is controlled by the sensor kinases DosS and DosT and the response regulator DosR through activation of the dormancy/NO (Dos) regulon...
  7. pmc Cooperative binding of phosphorylated DevR to upstream sites is necessary and sufficient for activation of the Rv3134c-devRS operon in Mycobacterium tuberculosis: implication in the induction of DevR target genes
    Santosh Chauhan
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India
    J Bacteriol 190:4301-12. 2008
    The DevR-DevS two-component system of Mycobacterium tuberculosis mediates bacterial adaptation to hypoxia, a condition believed to be associated with the initiation and maintenance of dormant bacilli during latent tuberculosis...
  8. pmc DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy
    Alexandra Ioanoviciu
    Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, California 94158 2517, USA
    Biochemistry 48:5839-48. 2009
    b>DevS is one of the two sensing kinases responsible for DevR activation and the subsequent entry of Mycobacterium tuberculosis into dormancy. Full-length wild-type DevS forms a stable oxy-ferrous complex...
  9. pmc Unique roles of DosT and DosS in DosR regulon induction and Mycobacterium tuberculosis dormancy
    Ryan W Honaker
    University of Colorado Denver, Department of Microbiology, Aurora, CO 80045, USA
    Infect Immun 77:3258-63. 2009
    In Mycobacterium tuberculosis, the sensor kinases DosT and DosS activate the transcriptional regulator DosR, resulting in the induction of the DosR regulon, which is important for anaerobic survival and perhaps latent infection...
  10. pmc Strains of the East Asian (W/Beijing) lineage of Mycobacterium tuberculosis are DosS/DosT-DosR two-component regulatory system natural mutants
    Ashley Fallow
    Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    J Bacteriol 192:2228-38. 2010
    ..regulatory system comprising the transcription factor DosR and two possible cognate histidine sensor kinases, DosS and DosT. Through sequence analysis of a carefully selected set of isolates representing each of the major M...