Genomes and Genes
Gene Symbol: Ywhae
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Alias: AU019196, 14-3-3 protein epsilon, 14-3-3 epsilon, 14-3-3E, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide
- Function of 14-3-3 proteinsD Y Jin
Nature 382:308. 1996
- An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channelXiubin Liang
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 283:27418-25. 2008....
- 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channelsXiubin Liang
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
J Biol Chem 281:16323-32. 2006..Our studies show that aldosterone increases the expression of 14-3-3beta, which interacts with phospho-Nedd4-2 to block its interaction with ENaC, thus enhancing sodium absorption by increasing apical membrane ENaC density...
- 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndromeKazuhito Toyo-oka
Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, Mailstop 0627, La Jolla, California 92093 0627, USA
Nat Genet 34:274-85. 2003..Here, we show that the gene encoding 14-3-3epsilon (YWHAE), one of a family of ubiquitous phosphoserine/threonine-binding proteins, is always deleted in individuals with ..
- 14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activationStefan Winter
Max F Perutz Laboratories, Vienna Biocenter, Medical University of Vienna, Vienna, Austria
EMBO J 27:88-99. 2008..Finally, siRNA-mediated loss of 14-3-3 proteins abolishes the transcriptional activation of HDAC1. Together our data indicate that 14-3-3 proteins are crucial mediators of histone phosphoacetylation signals...
- 14-3-3 proteins integrate E2F activity with the DNA damage responseAlasdair H Milton
Laboratory of Cancer Biology, Division of Medical Sciences, University of Oxford, UK
EMBO J 25:1046-57. 2006..These results identify a new level of control on E2F activity and, at a more general level, suggest that 14-3-3 proteins integrate E2F activity with the DNA damage response...
- Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteinsXiaofang Li
Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
J Biol Chem 279:34201-8. 2004..Together, our results suggest that calcium/calmodulin-dependent kinase I-mediated phosphorylation of HDAC7 acts, in part, to promote association of HDAC7 with 14-3-3 and stabilizes HDAC7...
- Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profilingThomas Kislinger
Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5G 1L6, Canada
Cell 125:173-86. 2006..This molecular compendium, fully accessible via a searchable web-browser interface, serves as a reliable reference of the expressed tissue and organelle proteomes of a leading model mammal...
- CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3sChengzhuo Gao
Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
FEBS Lett 580:5096-104. 2006..Taken together, these results strongly suggest that CRM1 mediated-nuclear export of HDAC7 is independent of HDAC7 phosphorylation and its association with 14-3-3s...
- Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylationHangun Kim
College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500 757, Korea
J Biol Chem 283:977-87. 2008..These results highlight signaling events in the regulation of delta-catenin-induced dendrogenesis and spine morphogenesis...
- Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3epsilon haploinsufficiency in mice underscores complex pathogenicity in neurodegenerationPaymaan Jafar-Nejad
Department of Molecular and Human Genetics, and Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 108:2142-7. 2011..These data suggest that distinct pathogenic mechanisms operate in different vulnerable brain regions, adding another level of complexity to SCA1 pathogenesis...
- Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)Rebecca L Stead
Centre for Biological Sciences, Building 85, University of Southampton, Southampton SO17 1BJ, United Kingdom
FEBS Lett 587:2623-8. 2013..Our findings have potentially important implications for the use of rapamycin and its analogues in cancer therapy, suggesting that inhibitors of mTOR and Mnk (or Mnk2) may be more efficacious than rapalogs alone. ..
- Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregationGolam Sadik
Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
J Neurochem 108:33-43. 2009..Also as the phosphorylation at Ser214 is up-regulated in Alzheimer's disease brain, tau's interaction with 14-3-3 might be involved in the pathology of this disease...
- The pro-inflammatory cytokine 14-3-3ε is a ligand of CD13 in cartilageMeriam Nefla
UMR_S938, CDR Saint Antoine INSERM University Pierre and Marie Curie Paris VI, Sorbonne Universités, 7 quai St Bernard, Paris 75252, Cedex 5, France Inflammation Immunopathology Biotherapy Department DHU i2B, a184 rue du Faubourg Saint Antoine, Paris 75012, France
J Cell Sci 128:3250-62. 2015..The 14-3-3ε-CD13 interaction could be a new therapeutic target in osteoarthritis. ..
- Deficiency of 14-3-3ε and 14-3-3ζ by the Wnt1 promoter-driven Cre recombinase results in pigmentation defectsBrett Cornell
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, 19129, USA
BMC Res Notes 9:180. 2016..Here, we test the function of 14-3-3 proteins in the development of neural crest cells in vivo using mouse genetic approaches...
- AS160 modulates aldosterone-stimulated epithelial sodium channel forward traffickingXiubin Liang
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Mol Biol Cell 21:2024-33. 2010....
- 14-3-3epsilon controls multiple developmental processes in the mouse heartAdriana C Gittenberger-de Groot
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Dev Dyn 245:1107-1123. 2016..However, additional cardiac defects are possible given the ubiquitous expression pattern of this protein...
- Intracellular targeting of peroxiredoxin 6 to lysosomal organelles requires MAPK activity and binding to 14-3-3εElena M Sorokina
Institute for Environmental Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, PA 19104, USA
Am J Physiol Cell Physiol 300:C1430-41. 2011..These findings suggest that ERK and p38 MAPK regulate subcellular localization of Prdx6 by activation of 14-3-3ε as a chaperone protein, resulting in its translocation to acidic organelles...
- Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stressXiaoZhe Wang
Dana Farber Cancer Institute and Division of Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 279:49460-9. 2004..Association of HSF1 with ERK and 14-3-3epsilon during heat shock may thus modulate the amplitude of the response and lead to efficient termination of HSP expression on resumption of growth conditions...
- 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brainKazuhito Toyo-oka
Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco School of Medicine, San Francisco, California 94143, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
J Neurosci 34:12168-81. 2014..Our findings provide new evidence that 14-3-3 proteins play important roles in neurogenesis and neuronal migration via the regulation of distinct signaling cascades. ..
- Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7H Y Kao
Department of Biochemistry, School of Medicine, Case Western Reserve University, University Hospitals of Cleveland, 10900 Euclid Ave, Cleveland, OH 44106, USA
J Biol Chem 276:47496-507. 2001..The data also show that the cellular concentration of factors such as 14-3-3, CaMK I, and other yet unknown molecules may determine the subcellular localization of an individual HDAC member in a cell type and HDAC-specific manner...
- Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradationSabine S Neukamm
Division of Clinical Chemistry and Pathobiochemistry, Department of Internal Medicine IV, University Hospital Tuebingen, Tuebingen 72076, Germany
J Biol Chem 288:16403-15. 2013..We present serine 1137/1138 as novel cAMP-dependent phosphorylation sites on IRS2 and show their importance in 14-3-3 binding and IRS2 protein stability...
- 14-3-3ε marks the amyloid-stimulated microglia long-term activationLaura Di Francesco
Dipartimento di Scienze Biochimiche, Sapienza, University of Rome, Rome, Italy
Proteomics 12:124-34. 2012....
- Transrepression activity of T-box1 in a gene regulation network in mouse cellsKaren K L Yee
Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo 162 8666, Japan
Gene 510:162-70. 2012..We identified 127 genes that were potentially transrepressed by Tbx1. Of the transrepressed genes, we focused on Ywhae and C1qbp and carried out promoter assays...
- Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's diseaseXianting Li
Department of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America
PLoS ONE 6:e17153. 2011..The molecular mechanism underlying the pathogenic role of LRRK2 mutations in PD remains unknown...
- 14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycleYasuhiro Kosaka
Departments of Pediatrics, The University of Utah School of Medicine, Salt Lake City, Utah, USA
Mol Cell Biol 32:5089-102. 2012..These data are consistent with the long-held view that human LVNC may result from compaction arrest, and they implicate 14-3-3ε as a new candidate gene in congenital human cardiomyopathies...
- 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossingPatricia T Yam
Molecular Biology of Neural Development, Institut de Recherches Cliniques de Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
Neuron 76:735-49. 2012..Therefore, we identify a 14-3-3 protein-dependent mechanism for a cell-intrinsic temporal switch in the polarity of axon turning responses...
- The role of 14-3-3ε interaction with phosphorylated Cdc25B at its Ser321 in the release of the mouse oocyte from prophase I arrestJun Meng
Department of Biochemical and Molecular Biology, China Medical University, Shenyang, Liaoning Province, China
PLoS ONE 8:e53633. 2013..Taken together, these data indicate that Ser321 of Cdc25B is the specific binding site for 14-3-3ε binding, and that 14-3-3ε is the significant factor in Cdc25B regulation during meiotic resumption of GV stage...
- Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's diseaseT A Yacoubian
Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Cell Death Dis 1:e2. 2010....
- Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent mannerAmy J Ramsey
Department of Pharmacology and Toxicology, University of Toronto, ON, Canada M5S 1A8
Proc Natl Acad Sci U S A 108:5795-800. 2011..The synaptic reduction of DISC1 and 14-3-3ε is developmentally correlated with the age-dependent decrease in striatal spine density...
- Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cellsYidong Shen
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Dev Cell 14:342-53. 2008..Nudel facilitates cell migration by sequestering Cdc42GAP at the leading edge to stabilize active Cdc42 in response to extracellular stimuli. Excess active Cdc42 may in turn control its own activity by recruiting Cdc42GAP from Nudel...
- Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛO Barbash
The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
Oncogene 30:1995-2002. 2011..Collectively, the current results suggest a model wherein 14-3-3ɛ binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function...
- Phosphoproteomic identification of a PDX-1/14-3-3ε interaction in pancreatic beta cellsP Ziegler
Department of Medical Biochemistry and Molecular Biology, University of Greifswald, Greifswald, Germany
Horm Metab Res 43:165-70. 2011..We propose that 14-3-3ε interacts directly with PDX-1 to regulate its cellular distribution in pancreatic beta cells...
- Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophreniaHirotaka Sekiguchi
Department of Psychiatry, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, Aichi 466 8550, Japan
Brain Res 1392:47-53. 2011..There is thought to be a dysfunction of a neurotransmitter such as dopamine and noradrenalin in the prefrontal cortex of these knockout mice...
- Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defectsTiziano Pramparo
Department of Pediatrics and Institute for Human Genetics, School of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 7:e1001331. 2011..Targeted gene mutations of Lis1, Dcx, Ywhae (coding for 14-3-3ε), and Ndel1 lead to neuronal migration defects in mouse and provide models of human ..
- Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouseJessica Yingling
Departments of Pediatrics and Medicine, University of California at San Diego School of Medicine, La Jolla, CA, 92093, USA
Am J Hum Genet 73:475-88. 2003
- Molecular evolution of the 14-3-3 protein familyW Wang
Department of Biology, University of Houston, Houston, TX 77204 5513, USA
J Mol Evol 43:384-98. 1996..A possible ancestral 14-3-3 sequence is proposed...
- 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome regionS S Chong
National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
Genome Res 6:735-41. 1996..3). However, 14-3-3 epsilon lies telomeric to LIS1 and outside the Miller-Dieker syndrome chromosome region but in a region frequently deleted in several types of cancer, and is a reasonable candidate tumor suppressor gene...
- Protein binding and signaling properties of RIN1 suggest a unique effector functionL Han
Department of Biological Chemistry, Molecular Genetics, and Immunology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 94:4954-9. 1997..These data suggest that RIN1 is able to mediate multiple signals. A differential pattern of expression and alternate splicing indicate several levels of RIN1 regulation...
- The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppressionB A Hamilton
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Neuron 18:711-22. 1997..The vibrator phenotype is suppressed in one intercross. We performed a complete genome scan and mapped a major suppressor locus (Mvb-1) to proximal chromosome 19...
- Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human regionS Hirotsune
Genome Res 7:625-34. 1997..Our results demonstrate that the MDS region is conserved between human and mouse. This conservation of linkage suggests that the mouse can be used to model microdeletions that occur in ILS and MDS...
- Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteinsB S Finlin
Department of Biochemistry, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky, 40536 0084, USA
Arch Biochem Biophys 368:401-12. 1999..These results suggest that 14-3-3 may allow the recruitment of distinct proteins that participate in Rem-mediated signal transduction pathways...
- Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brainH C Baxter
Department of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, Scotland, UK
Neuroscience 109:5-14. 2002..The fact that isoform labelling in terminal scrapie CNS is lost in some brain areas, but increases in others, suggests that the processing of these proteins during neurodegeneration may be much more complex than previously recognised...
- RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domainJiaxin Niu
Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, U S A
Biochem J 365:677-84. 2002..This study describes a new level in the regulation of G-protein signalling, in which the inhibitors of G-proteins, RGS proteins, can themselves be regulated by phosphorylation and binding 14-3-3...
- A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplexAlanna L Eilers
Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 5550, USA
Mol Cell Biol 22:8514-26. 2002..Second, an extracellular signal(s) must overcome the cytoplasmic localization function imparted by CRM1 and 14-3-3 binding to the N terminus of MondoA...
- Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migrationSimon Hippenmeyer
Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA
Neuron 68:695-709. 2010..Comparisons with previous genetic perturbations of Lis1 and Ndel1 also suggest a surprising degree of cell-nonautonomous function for these proteins in regulating neuronal migration...
- CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent mannerKrista L Clark
Program in Molecular, Cellular and Developmental Biology, Division of Biology, 239C Chalmers Hall, Kansas State University, Manhattan, KS 66506, USA
J Biol Chem 279:19401-6. 2004..These finding suggest that CD81 signaling events could be mediated by 14-3-3 adapter proteins, and these signals may be dependent on cellular redox...
- MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alphaMarco Castelli
Serono Pharmaceutical Research Institute, Serono International S A, Plan les Ouates 1228, Geneva CH1228, Switzerland
J Biol Chem 279:44731-9. 2004..In addition, we demonstrated that CK2 selectively phosphorylates MKP3, suggesting cross-regulation between CK2alpha and MKP3, as well as a modulation of ERK2-MAPK signaling by CK2alpha via MKP3...
- Phosphorylation of grb10 regulates its interaction with 14-3-3Susanne Urschel
Department of Internal Medicine III, Laboratory of Leukemogenesis, Technical University of Munich, 81675 Munich, Germany
J Biol Chem 280:16987-93. 2005..Based on these findings, we propose a regulatory circuitry involving a phosphorylation-regulated complex formation of Grb10 with 14-3-3 and Akt...
- Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profilingC Machka
Institute of Experimental Genetics, GSF National Research Center, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
Gene Expr Patterns 6:94-101. 2005..The large set of regulated genes identified in this differential expression profiling approach is an important resource for further functional studies...
- Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signalingPierre Olivier Angrand
Cellzome AG and the European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
Mol Cell Proteomics 5:2211-27. 2006....
- 14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phaseEmi Mizuno
Department of Biological Sciences, Tokyo Institute of Technology, 4259 B 16 Nagatsuta, Yokohama, Japan
Exp Cell Res 313:3624-34. 2007..We conclude that UBPY is catalytically inhibited in a phosphorylation-dependent manner by 14-3-3s during the interphase, and this regulation is cancelled in the M phase...
- The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiationJ E McConnell
MRC Human Genetics Unit, Edinburgh, United Kingdom
Dev Biol 169:218-28. 1995..The results as a whole thus argue for the 14-3-3 epsilon isoform playing roles in neural development and in early mesenchyme, with this latter function being lost or replaced as the tissue differentiates...
- Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferationAna Lonic
Division of Human Immunology, Institute of Medical and Veterinary Science, Frome Rd Adelaide, South Australia, Australia
Mol Cell Biol 28:3372-85. 2008..In this regard, we have identified conserved putative phosphotyrosine/phosphoserine motifs in the cytoplasmic domains of diverse cell surface receptors, suggesting that they may perform important functional roles beyond the FGFRs...
- Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophreniaMasashi Ikeda
Department of Psychiatry, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
Hum Mol Genet 17:3212-22. 2008..we screened for DISC1-interacting molecules [NudE-like (NUDEL), Lissencephaly-1 (LIS1), 14-3-3epsilon (YWHAE), growth factor receptor bound protein 2 (GRB2) and Kinesin family 5A of Kinesen1 (KIF5A)], assessing a total of ..
- Regulation of histone deacetylase 7 (HDAC7) activityHung Ying Kao; Fiscal Year: 2006..Understanding how cellular signaling controls HDAC activities will help to understand deregulated cell growth in cancer and may have therapeutic implications for cancer treatment. ..
- NF-kB activating genePatent Number: WO03048202-A2; Date:2003-06-12