Xbp1

Summary

Gene Symbol: Xbp1
Description: X-box binding protein 1
Alias: D11Ertd39e, TREB-5, TREB5, XBP-1, X-box-binding protein 1, tax-responsive element-binding protein 5 homolog
Species: mouse

Top Publications

  1. ncbi XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks
    Diego Acosta-Alvear
    New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 27:53-66. 2007
  2. ncbi Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage
    T Masaki
    Kanagawa Academy of Science and Technology in Meiji Institute of Health Science, Meiji Milk Products Co Ltd, 540 Naruda, Kanagawa, Odawarashi, 250 0862, Japan
    Biochem Biophys Res Commun 261:350-6. 1999
  3. ncbi Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
    Keisuke Yamamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Dev Cell 13:365-76. 2007
  4. pmc Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection
    Daisuke Kamimura
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 181:5433-41. 2008
  5. doi Endoplasmic reticulum stress plays a central role in development of leptin resistance
    Lale Ozcan
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 9:35-51. 2009
  6. pmc Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1
    Mary E B Martino
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 284:14904-13. 2009
  7. pmc An essential role in liver development for transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 USA
    Genes Dev 14:152-7. 2000
  8. ncbi IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
  9. ncbi Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
    Neal N Iwakoshi
    Department of Immunology and Infectious Diseases, Harvard School of Public Health 651 Huntington Avenue, Boston, Massachusetts 02115 6017, USA
    Nat Immunol 4:321-9. 2003
  10. pmc XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:7448-59. 2003

Scientific Experts

Detail Information

Publications109 found, 100 shown here

  1. ncbi XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks
    Diego Acosta-Alvear
    New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 27:53-66. 2007
    Using genome-wide approaches, we have elucidated the regulatory circuitry governed by the XBP1 transcription factor, a key effector of the mammalian unfolded protein response (UPR), in skeletal muscle and secretory cells...
  2. ncbi Targeted disruption of CRE-binding factor TREB5 gene leads to cellular necrosis in cardiac myocytes at the embryonic stage
    T Masaki
    Kanagawa Academy of Science and Technology in Meiji Institute of Health Science, Meiji Milk Products Co Ltd, 540 Naruda, Kanagawa, Odawarashi, 250 0862, Japan
    Biochem Biophys Res Commun 261:350-6. 1999
    b>TREB5 (hXBP-1) is a basic region leucine zipper protein which binds to a CRE-like element in both human T-cell leukemia virus type 1 and MHC class II genes...
  3. ncbi Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
    Keisuke Yamamoto
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Dev Cell 13:365-76. 2007
    ..is solely responsible for transcriptional induction of ER chaperones and that ATF6alpha heterodimerizes with XBP1 for the induction of ER-associated degradation components. ATF6alpha(-/-) MEFs are sensitive to ER stress...
  4. pmc Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection
    Daisuke Kamimura
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Immunol 181:5433-41. 2008
    ..These results suggest that, in the response to pathogen, activation of ER stress sensors and XBP-1 splicing contribute to the differentiation of end-stage effector CD8(+) T cells...
  5. doi Endoplasmic reticulum stress plays a central role in development of leptin resistance
    Lale Ozcan
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 9:35-51. 2009
    ..Taken together, our results may provide the basis for a novel treatment of obesity...
  6. pmc Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1
    Mary E B Martino
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 284:14904-13. 2009
    ..These findings suggest that, in inflamed HBE, XBP-1s is responsible for the ER/Ca(2+) store expansion that confers amplification of Ca(2+)-dependent inflammatory responses...
  7. pmc An essential role in liver development for transcription factor XBP-1
    A M Reimold
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115 USA
    Genes Dev 14:152-7. 2000
    ..Therefore, XBP-1 is a transcription factor essential for hepatocyte growth...
  8. ncbi IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    Marcella Calfon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nature 415:92-6. 2002
    ..Our findings suggest that physiological ER load regulates a developmental decision in higher eukaryotes...
  9. ncbi Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
    Neal N Iwakoshi
    Department of Immunology and Infectious Diseases, Harvard School of Public Health 651 Huntington Avenue, Boston, Massachusetts 02115 6017, USA
    Nat Immunol 4:321-9. 2003
    ..We also show that XBP-1 is involved in controlling the production of interleukin-6, a cytokine that is essential for plasma cell survival. Thus, signals upstream and downstream of XBP-1 integrate plasma cell differentiation with the UPR...
  10. pmc XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mol Cell Biol 23:7448-59. 2003
    ..Further, our observations suggest the existence of additional, as-yet-unknown, key regulators of the UPR...
  11. ncbi A transgenic mouse model for monitoring endoplasmic reticulum stress
    Takao Iwawaki
    Laboratory for Cell Recovery Mechanisms, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Med 10:98-102. 2004
    ..We used transgenic animals expressing the ER stress indicator to show that it can be used to monitor physiological and pathological ER stress in vivo...
  12. ncbi XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation
    A L Shaffer
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 21:81-93. 2004
    ..of B cells into immunoglobulin-secreting plasma cells is controlled by two transcription factors, Blimp-1 and XBP1. By gene expression profiling, we defined a set of genes whose induction during mouse plasmacytic differentiation ..
  13. pmc XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
    Rungtawan Sriburi
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    J Cell Biol 167:35-41. 2004
    ..Here, we report that enforced expression of XBP1(S), the active form of the XBP1 transcription factor generated by UPR-mediated splicing of XBP1 mRNA, is sufficient ..
  14. ncbi Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    Umut Ozcan
    Department of Genetics and Complex Diseases, Harvard Medical School, Boston, MA 02115, USA
    Science 306:457-61. 2004
    ..Pharmacologic manipulation of this pathway may offer novel opportunities for treating these common diseases...
  15. pmc XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells
    Boaz Tirosh
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 202:505-16. 2005
    ..We conclude that in primary B cells, the XBP-1 pathway promotes synthesis and secretion of IgM, but does not seem to be involved in the degradation of ER proteins, including that of mu chains themselves...
  16. ncbi Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response
    Boaz Tirosh
    Whitehead Institute for Biomedical Research, Harvard School of Public Health, Boston, MA 02115, USA
    J Biol Chem 281:5852-60. 2006
    ..We suggest that the degradation of Xbp-1u is required to prevent uncontrolled activation of the UPR while allowing short dwell times for initiation of this response...
  17. pmc XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    EMBO J 24:4368-80. 2005
    ..These data lead us to propose that XBP-1 is both necessary and sufficient for the full biogenesis of the secretory machinery in exocrine cells...
  18. pmc GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development
    Shengzhan Luo
    Department of Biochemistry and Molecular Biology and the USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089 9176, USA
    Mol Cell Biol 26:5688-97. 2006
    ..These findings provide the first evidence that GRP78 is essential for embryonic cell growth and pluripotent cell survival...
  19. pmc Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
    D Thomas Rutkowski
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    PLoS Biol 4:e374. 2006
    ..It underscores the contribution of posttranscriptional and posttranslational mechanisms in influencing this outcome...
  20. ncbi Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis
    Rungtawan Sriburi
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA
    J Biol Chem 282:7024-34. 2007
    ..We propose that XBP-1(S) regulates ER abundance by coordinately increasing the supply of membrane phospholipids and ER proteins, the key ingredients for ER biogenesis...
  21. pmc The transcription factor XBP-1 is essential for the development and survival of dendritic cells
    Neal N Iwakoshi
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 204:2267-75. 2007
    ..Overexpression of XBP-1 in hematopoietic progenitors rescued and enhanced DC development. Remarkably, in contrast to other cell types we have examined, the XBP-1 pathway was constitutively activated in immature DCs...
  22. pmc Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
    Claudio Hetz
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:757-62. 2008
    ....
  23. pmc Regulation of hepatic lipogenesis by the transcription factor XBP1
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 320:1492-6. 2008
    ..We found that the transcription factor XBP1, a key regulator of the unfolded protein response, is required for the unrelated function of normal fatty acid ..
  24. pmc XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    Arthur Kaser
    Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Cell 134:743-56. 2008
    ..The transcription factor XBP1, a key component of the endoplasmic reticulum (ER) stress response, is required for development and maintenance of ..
  25. pmc The unfolded protein response contributes to preimplantation mouse embryo death in the DDK syndrome
    Lanping Hao
    Fels Institute for Cancer Research and Molecular Biology, Temple University Medical School, Philadelphia, Pennsylvania, USA
    Biol Reprod 80:944-53. 2009
    ..Our results indicate that the unfolded protein response is induced in embryos destined to die of DDK syndrome and that the embryonic death observed is associated with inability to resolve the associated ER stress...
  26. pmc Preventing oxidative stress: a new role for XBP1
    Y Liu
    Division of Molecular Oncology and Molecular Diagnosis, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Cell Death Differ 16:847-57. 2009
    ..We have investigated the contribution of X-box-binding protein (XBP1), a major endoplasmic reticulum stress-linked transcriptional factor, to cellular resistance to oxidative stress...
  27. pmc BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha
    Fernanda Lisbona
    Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell, University of Chile, Santiago, Chile
    Mol Cell 33:679-91. 2009
    ..Our results suggest a role for BI-1 in early adaptive responses against ER stress that contrasts with its known downstream function in apoptosis...
  28. pmc XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
    Chih Chi Andrew Hu
    Department of Biology, Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    EMBO J 28:1624-36. 2009
    ..They fail to colonize the bone marrow and do not sustain antibody production. These findings define the role of XBP-1 in normal plasma cell development and have implications for management of B-cell malignancies...
  29. pmc Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow
    Lingfang Zeng
    Cardiovascular Division, King s College London BHF Centre, London, United Kingdom
    Proc Natl Acad Sci U S A 106:8326-31. 2009
    X-box binding protein 1 (XBP1) is a key signal transducer in endoplasmic reticulum stress response, and its potential role in the atherosclerosis development is unknown...
  30. doi De novo ceramide synthesis is required for N-linked glycosylation in plasma cells
    Meidan Goldfinger
    Department of Pharmacology and Experimental Therapeutics, School of Pharmacy, The Hebrew University, Jerusalem, Israel
    J Immunol 182:7038-47. 2009
    ..Our results underscore ceramide biosynthesis as a key metabolic pathway in the process of PC differentiation and reveal a previously unknown functional link between sphingolipids and N-linked glycosylation in PCs...
  31. pmc The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis
    Haibo Sha
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Cell Metab 9:556-64. 2009
    ..Here we demonstrate that the IRE1alpha-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis...
  32. pmc XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
    Derrick J Todd
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 206:2151-9. 2009
    ..b>X box binding protein 1 (XBP1) is a transcription factor that mediates one branch of the UPR and is crucial for the development ..
  33. pmc XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
    Claudio Hetz
    Institute of Biomedical Sciences, The FONDAP Center for Molecular Studies of the Cell CEMC and the Millennium Nucleus for Neural Morphogenesis NEMO, University of Chile, Santiago, Chile
    Genes Dev 23:2294-306. 2009
    ..Our results reveal a new function of XBP-1 in the control of autophagy and indicate critical cross-talk between these two signaling pathways that can provide protection against neurodegeneration...
  34. pmc Lipid-like materials for low-dose, in vivo gene silencing
    Kevin T Love
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1864-9. 2010
    ..03 mg/kg. To our knowledge, this formulation facilitates gene silencing at orders-of-magnitude lower doses than required by any previously described siRNA liver delivery system...
  35. pmc The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation
    Sang Won Park
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:429-37. 2010
    ..Our results define a previously unknown insulin receptor signaling pathway and provide new mechanistic insight into the development of ER stress during obesity...
  36. pmc TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    Fabio Martinon
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Immunol 11:411-8. 2010
    ..the endoplasmic reticulum (ER) stress sensor kinase IRE1alpha and its downstream target, the transcription factor XBP1. Previously described ER-stress target genes of XBP1 were not induced by TLR signaling...
  37. pmc SUMO modification regulates the transcriptional activity of XBP1
    Hui Chen
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Biochem J 429:95-102. 2010
    ..b>XBP1 (X-box-binding protein 1), a key transcription factor of the UPR, is critical in maintaining ER homoeostasis...
  38. pmc XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages
    Ling Zeng
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Immunol 185:2324-30. 2010
    ..Our findings have broader mechanistic implications for the pathogenesis of diseases involving ER stress and type I IFN, including viral infection, ischemia-reperfusion injury, protein misfolding, and inflammatory diseases...
  39. pmc XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum
    Won Jae Huh
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 139:2038-49. 2010
    ..The transcription factor MIST1 is required for granulogenesis of ZCs. The transcription factor XBP1 binds the Mist1 promoter and induces its expression in vitro and expands the ER in other cell types...
  40. pmc Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation
    Feng Ming Wang
    Division of Hematology and Oncology, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh PA 15240, USA
    Biochem J 433:245-52. 2011
    b>XBP1 (X-box-binding protein 1) is a key modulator of the UPR (unfolded protein response), which is involved in a wide range of pathological and physiological processes...
  41. pmc Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1
    Jingming Li
    Department of Medicine, Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 286:4912-21. 2011
    ..In the present study, we investigated the role of X-box binding protein 1 (XBP1) in retinal adhesion molecule expression, leukostasis, and vascular leakage...
  42. pmc Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction
    Yingjiang Zhou
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:356-65. 2011
    ....
  43. pmc ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells
    Fanlei Hu
    Center for Human Disease Genomics, School of Basic Medical Science, Peking University, Beijing, PR China
    Eur J Immunol 41:1086-97. 2011
    ..Our findings suggest that evolutionarily conserved ER stress response and XBP-1 may function collaboratively with innate immunity to maintain cellular homeostasis...
  44. pmc Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion
    Ann Hwee Lee
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:8885-90. 2011
    As a key regulator of the unfolded protein response, the transcription factor XBP1 activates genes in protein secretory pathways and is required for the development of certain secretory cells...
  45. pmc p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis
    Jaemin Lee
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:1251-60. 2011
    ....
  46. pmc Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice
    Michael J Jurczak
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
    J Biol Chem 287:2558-67. 2012
    ..The ER stress response protein, X-box-binding protein-1 (XBP1), was recently shown to regulate hepatic lipogenesis, suggesting that hepatic insulin resistance in models of ER ..
  47. pmc A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation
    Mithu Majumder
    Departments of Nutrition, Case Western University School of Medicine, Cleveland, Ohio, USA
    Mol Cell Biol 32:992-1003. 2012
    ..which initiates cytoplasmic splicing of the mRNA encoding the transcription factor X-box binding protein 1 (XBP1). XBP1 induces transcription of genes involved in protein quality control...
  48. pmc IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
    Kyu Yeon Hur
    Deartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 209:307-18. 2012
    ..unfolded protein, or endoplasmic reticulum (ER), stress response by activating its downstream transcription factor XBP1 via an unconventional splicing mechanism...
  49. pmc Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
    René L Vidal
    Faculty of Medicine, Neuroscience Biomedical Institute, University of Chile, Santiago, Chile
    Hum Mol Genet 21:2245-62. 2012
    ..the functional contribution of ER stress to HD by targeting the expression of two main UPR transcription factors, XBP1 and ATF4 (activating transcription factor 4), in full-length mutant Huntingtin (mHtt) transgenic mice...
  50. pmc IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis
    Shiyu Wang
    Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Metab 16:473-86. 2012
    ..identify an essential role for the inositol-requiring transmembrane kinase/endoribonuclease 1α (IRE1α)-X box binding protein 1 (XBP1) arm of the UPR in regulation of hepatic very low-density lipoprotein (VLDL) assembly and secretion...
  51. pmc Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice
    Jae Seon So
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 16:487-99. 2012
    b>XBP1 is a key regulator of the unfolded protein response (UPR), which is involved in a wide range of physiological and pathological processes...
  52. pmc The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism
    Yingfeng Deng
    Touchstone Diabetes Center, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 123:455-68. 2013
    ..Our results provide evidence that the Xbp1s/GalE pathway functions as a novel regulatory nexus connecting the UPR to the characteristic postprandial metabolic changes in hepatocytes...
  53. pmc X-box binding protein 1 is essential for insulin regulation of pancreatic α-cell function
    Masaru Akiyama
    Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 62:2439-49. 2013
    ..X-box binding protein 1 (XBP1) is a transcription factor that plays a crucial role in the unfolded protein response (UPR), and its deficiency in ..
  54. doi X-box binding protein 1 enhances adipogenic differentiation of 3T3-L1 cells through the downregulation of Wnt10b expression
    Yoon Mi Cho
    Department of Biochemistry, The Catholic University of Korea, Seoul 137 701, Republic of Korea
    FEBS Lett 587:1644-9. 2013
    ..Recently, the pro-adipogenic function of XBP1, a transcription factor upregulated by endoplasmic reticulum stress, has been reported...
  55. pmc Paneth cells as a site of origin for intestinal inflammation
    Timon E Adolph
    1 Division of Gastroenterology and Hepatology, Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK 2
    Nature 503:272-6. 2013
    ..Deletion of the unfolded protein response (UPR) transcription factor X-box binding protein-1 (Xbp1) in intestinal epithelial cells, the human orthologue of which harbours rare inflammatory bowel disease risk ..
  56. doi Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells
    Sandrine Benhamron
    Institute for Drug Research, The School of Pharmacy, The Hebrew University, Jerusalem, Israel
    Eur J Immunol 44:867-76. 2014
    Inositol-requiring enzyme 1 (IRE1) is a kinase and ribonuclease that executes the splicing of X box binding protein 1 (XBP-1) mRNA in response to the accumulation of unfolded protein in the ER, a signal cascade termed the unfolded ..
  57. ncbi In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis
    I M Clauss
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115
    Dev Dyn 197:146-56. 1993
    ..It is intriguing that the promoter regions of several such genes contain potential hXBP-1 binding sites...
  58. pmc Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
    Takao Iwawaki
    Iwawaki Initiative Research Unit, Advanced Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, Japan
    Proc Natl Acad Sci U S A 106:16657-62. 2009
    ..These findings reveal that IRE1alpha plays an essential function in extraembryonic tissues and highlight the relationship of physiological ER stress and angiogenesis in the placenta during pregnancy in mammals...
  59. ncbi Identification of ERdj3 and OBF-1/BOB-1/OCA-B as direct targets of XBP-1 during plasma cell differentiation
    Ying Shen
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 179:2969-78. 2007
    ..In addition, our data further define the XBP-1(S)-binding sequence and provide yet another role for this protein as a master regulator of plasma cell differentiation...
  60. ncbi High rate of antibody secretion is not integral to plasma cell differentiation as revealed by XBP-1 deficiency
    Nadine Taubenheim
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Immunol 189:3328-38. 2012
    ..Thus, XBP-1 deficiency demonstrates that the gene regulatory program controlling plasma cell differentiation can proceed relatively normally in the absence of high rates of Ig secretion...
  61. pmc GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice
    Edwin T Parlevliet
    Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e49152. 2012
    ..The aim of this study was to evaluate the effect of GLP-1 receptor agonism on very-low-density lipoprotein (VLDL)-TG production and liver TG metabolism...
  62. doi The balance between adaptive and apoptotic unfolded protein responses regulates β-cell death under ER stress conditions through XBP1, CHOP and JNK
    Jeng Yie Chan
    Garvan Institute of Medical Research, St Vincent s Hospital, UNSW Australia, Sydney, NSW, Australia
    Mol Cell Endocrinol 413:189-201. 2015
    ..Here, we investigated the relationships between XBP1, CHOP and JNK in the transition from adaptive to apoptotic UPR and β-cell death in models of type 1 and type 2 ..
  63. pmc Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1
    Judith A Smith
    William S Rowe Division of Rheumatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Eur J Immunol 38:1194-203. 2008
    ....
  64. pmc Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality
    Adam B Francisco
    Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York 14850, USA
    J Biol Chem 285:13694-703. 2010
    ..Taken together, our results demonstrate an essential role for SEL1L in protein quality control during mouse embryonic development...
  65. doi Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice
    Dewei Ye
    Department of Medicine, The University of Hong Kong, Hong Kong
    Gut 61:1058-67. 2012
    ..Non-alcoholic fatty liver disease is an obesity-related chronic liver disorder ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may progress to liver fibrosis and cirrhosis...
  66. pmc SEC23B is required for the maintenance of murine professional secretory tissues
    Jiayi Tao
    Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 109:E2001-9. 2012
    ....
  67. pmc Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells
    Toru Hosoi
    Department of Pharmacotherapy, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan
    PLoS ONE 7:e40144. 2012
    ..Immunohistochemical analysis suggested that CK2 was present at the ER. These results indicate CK2 to be linked with UPR and to resist ER stress by activating the XBP-1-GRP78 arm of UPR...
  68. pmc Inhibition of endoplasmic reticulum stress improves mouse embryo development
    Jin Yu Zhang
    Department of Animal Science and Biotechnology, Research Center for Transgenic Cloned Pigs, Chungnam National University, Daejeon, Korea
    PLoS ONE 7:e40433. 2012
    ..TUDCA inhibits hyperosmolar-induced ER stress as well as ER stress-induced apoptosis during mouse preimplantation embryo development...
  69. pmc XBP1S associates with RUNX2 and regulates chondrocyte hypertrophy
    Yanna Liu
    Department of Cell Biology and Genetics, Core Facility of Development Biology, Chongqing Medical University, Chongqing 400016, China
    J Biol Chem 287:34500-13. 2012
    ..This expression is probably due to the activation of the XBP1 gene by ATF6 and splicing by IRE1a...
  70. pmc Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization
    Li Liu
    Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida 32610, USA
    Am J Pathol 182:1412-24. 2013
    ..In conclusion, activation of the UPR sustains angiogenesis by preventing degradation of intracellular VEGF. The IRE1α/ATF6 arms of the UPR offer a potential therapeutic target in the treatment of pathological angiogenesis...
  71. doi Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins
    Daisuke Oikawa
    Iwawaki lab, Advanced Scientific Research Leaders Development Unit, Gunma University, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 433:426-31. 2013
    IRE1α is an ER-located transmembrane RNase whose activation leads to the production of the transcriptional factor, XBP1. Recently, many studies report that IRE1α-XBP1 pathway has novel and significant roles in placenta...
  72. pmc The role of adipocyte XBP1 in metabolic regulation during lactation
    Margaret F Gregor
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Rep 3:1430-9. 2013
    ..organelle endoplasmic reticulum (ER) in adapting to fluctuations in synthetic processes, we explored the role of XBP1, a central regulator of ER adaptive responses, in adipocyte formation and function...
  73. ncbi Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm
    D ten Berge
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Dev Biol 199:11-25. 1998
    ..Intriguingly, expression and to some extent function of aristaless and Distal-less in Drosophila also have overlapping as well as complementary aspects. Alx3 was localized to chromosome 3, near the droopy-ear (de) mutation...
  74. ncbi Isolation and characterization of the gene encoding mouse tax-responsive element-binding protein (TREB) 5
    T Masaki
    Department of Physiology, Toho University School of Medicine, Tokyo, Japan
    DNA Res 7:187-93. 2000
    b>TREB5/hXBP-1/HTF is a basic region leucine zipper protein which binds to a cyclic AMP responsive element (CRE)-like element in both human T-cell leukemia virus type 1 and human major histocompatibility complex (MHC) class II genes...
  75. ncbi Brain trauma induces X-box protein 1 processing indicative of activation of the endoplasmic reticulum unfolded protein response
    Wulf Paschen
    Laboratory of Molecular Nurology, Max Planck Institute for Neurological Research, Koeln, Germany
    J Neurochem 88:983-92. 2004
    ..Changes in levels of processed X-box protein 1 (xbp1), glucose-regulated protein 78 (grp78), growth arrest and DNA damage-inducible gene 153 (gadd153) and heat-shock ..
  76. ncbi Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II
    Keisuke Yamamoto
    Graduate School of Biostudies, Kyoto University, Kyoto 606 8502, Japan
    J Biochem 136:343-50. 2004
    ATF6 and XBP1 are transcription factors activated specifically in response to endoplasmic reticulum (ER) stress...
  77. ncbi XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress
    Soshi Kanemoto
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 331:1146-53. 2005
    ..protein kinase/endoribonuclease IRE1 is activated by endoplasmic reticulum stress and subsequently processes XBP1 mRNA to generate an active form of XBP1 protein...
  78. ncbi Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci
    Clifton M Ramsdell
    Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, South Carolina 29208, USA
    Mamm Genome 17:37-48. 2006
    ..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus...
  79. ncbi In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4
    Changhui Mao
    Department of Biochemistry and Molecular Biology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90089 9176, USA
    J Biol Chem 281:8877-87. 2006
    ..These results suggest that during early heart organogenesis, Grp78 can be activated through cooperation between the cell type-specific transcription factors and ERSE-binding factors...
  80. ncbi Endoplasmic reticulum stress response in dendrites of cultured primary neurons
    T Murakami
    Division of Molecular and Cellular Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki 889 1692, Japan
    Neuroscience 146:1-8. 2007
    ..Furthermore, XBP1 mRNA was localized in the proximal dendrites where IRE1 was rapidly phosphorylated in response to ER stress...
  81. ncbi The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development
    Akiko Hayashi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute RIKEN, Hirosawa, Wako Shi, Saitama, Japan
    J Biol Chem 282:34525-34. 2007
    ..Although Xbp1 serves as a pivotal transcription factor for the UPR, the physiological role of UPR signaling and Xbp1 in the ..
  82. doi Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum
    R Novosyadlyy
    Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Cell Death Differ 15:1304-17. 2008
    ....
  83. doi Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1
    Akiko Hayashi
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako Shi, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 376:758-63. 2008
    b>XBP1 is a transcription factor induced by unconventional splicing associated with endoplasmic reticulum stress and plays a role in development...
  84. doi Protective effect against Parkinson's disease-related insults through the activation of XBP1
    Megumi Sado
    Second Institute of New Drug Discovery, Otsuka Pharmaceutical Co, Ltd, 463 10 Kagasuno, Kawauchi cho, Tokushima 771 0192, Japan
    Brain Res 1257:16-24. 2009
    ..In this study, we investigated a role of the IRE1 alpha-XBP1 pathway in the survival of dopaminergic cells, under stress induced by PD-related insults...
  85. pmc p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival
    Takefumi Uemura
    Laboratory of Molecular Traffic, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371 8512, Japan
    Mol Cell Biol 29:1869-81. 2009
    ..Taken together, these results suggest that p31 is an essential molecule involved in the maintenance of ER morphology and that its deficiency leads to ER stress-induced apoptosis...
  86. pmc Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract
    Zeynep Firtina
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    J Biol Chem 284:35872-84. 2009
    ..Collectively, the results provide in vivo evidence for a role of UPR in cataract formation in response to accumulation of terminally unfolded proteins in the endoplasmic reticulum...
  87. doi Hemokinin-1 activates the MAPK pathway and enhances B cell proliferation and antibody production
    Wei Wang
    Department of Immunology, Peking University Health Science Center, Beijing, China
    J Immunol 184:3590-7. 2010
    ....
  88. doi Prolonged endoplasmic reticulum stress promotes mislocalization of immunoglobulins to the cytoplasm
    Adi Drori
    The Institute of Drug Research, The School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel
    Mol Immunol 47:1719-27. 2010
    ..Our data suggest that ASCs under prolonged ER stress conditions endure cytoplasmic mislocalization of Ig proteins. This mislocalization may further explain the exquisite sensitivity of multiple myeloma to proteasome inhibitors...
  89. doi Behavioral and gene expression analyses in heterozygous XBP1 knockout mice: Possible contribution of chromosome 11qA1 locus to prepulse inhibition
    Atsushi Takata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako City, Saitama, Japan
    Neurosci Res 68:250-5. 2010
    The Xbp1 gene, located on chromosome 11qA1 in Mus musculus, encodes a key transcription factor in the endoplasmic reticulum stress response pathway...
  90. pmc Activation of unfolded protein response in transgenic mouse lenses
    Lixing W Reneker
    Department of Ophthalmology, School of Medicine, University of Missouri, Columbia, Missouri, USA
    Invest Ophthalmol Vis Sci 52:2100-8. 2011
    ..The authors tested whether transgene overexpression in the mouse lens would activate the UPR...
  91. pmc Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cells
    M Kurata
    Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, 3 8 31 Ariake, Koto ku, Tokyo 135 8550, Japan
    Cell Death Dis 2:e118. 2011
    ..We have isolated apoptosis-resistant clones of BaF3 using retroviral insertional mutagenesis and the Xbp1 locus was identified as a retroviral integration site...
  92. pmc Dengue virus modulates the unfolded protein response in a time-dependent manner
    Jose Pena
    Division of Infectious Diseases and Vaccinology, School of Public Health, and Graduate Group in Microbiology, Department of Plant and Microbial Biology, University of California, Berkeley, California 94720 7354, USA
    J Biol Chem 286:14226-36. 2011
    ..and then suppresses PERK-mediated eIF2α phosphorylation and that in mid and late DENV-2 infection, the IRE1-XBP1 and ATF6 pathways are activated, respectively...
  93. pmc The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix
    Takahide Tohmonda
    Department of Anti aging Orthopedic Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    EMBO Rep 12:451-7. 2011
    ..mediators, inositol-requiring protein 1α (IRE1α), and its target transcription factor X-box binding protein 1 (XBP1), are essential for bone morphogenic protein 2-induced osteoblast differentiation...
  94. pmc Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice
    David A Hess
    Department of Biological Sciences and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907 2064, USA
    Gastroenterology 141:1463-72. 2011
    ....
  95. pmc Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress
    Clare L Kirkpatrick
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, Universite de Geneve, 1 rue Michel Servet, 1211 Geneve 4, Switzerland
    J Biol Chem 286:32300-12. 2011
    ..a transcription factor vital for correct β-cell development and function, to show that HNF1α is required for Xbp1 transcription and maintenance of the normal ER stress response...
  96. ncbi Increased expression of mXBP-1 (TREB-5) in thymic B cells in New Zealand mice
    N Taguchi
    Division of Rheumatology Allergy and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    J Autoimmun 16:401-10. 2001
    ..sequenced, and identified as the murine homologue of the human X box binding protein (hXBP-1), also known as TREB 5. mXBP-1 was found to be consistently upregulated in B cells in the thymic cortex of NZB and (NZBxNZW)F1, but not ..
  97. ncbi Expression of the novel transcription factor OASIS, which belongs to the CREB/ATF family, in mouse embryo with special reference to bone development
    T Nikaido
    Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Histochem Cell Biol 116:141-8. 2001
    ....
  98. ncbi Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in the BMP signaling pathway
    Hui Zhao
    Department of Zoophysiology, University of Essen, Universitatsstrasse 5, D 45117 Essen, Germany
    Dev Biol 257:278-91. 2003
    ..Taken together, the results suggest a role for XXBP-1 in the control of neural differentiation, possibly as an activator...
  99. ncbi Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation
    Jhagvaral Hasbold
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag Number 6, Newtown, NSW 2042, Australia
    Nat Immunol 5:55-63. 2004
    ..Stochastic division-linked regulation of heterogeneity challenges the conventional paradigms linking distinct phenotypes to unique combinations of signals and has the potential to simplify our concept of immune complexity considerably...
  100. ncbi Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo
    Changhui Mao
    Nat Med 10:1013-4; author reply 1014. 2004
  101. ncbi Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress
    Sung Hoon Back
    Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 281:18691-706. 2006
    ..Activated IRE1alpha cleaves XBP1 mRNA at two sites to initiate an unconventional splicing reaction...