Wnt3a

Summary

Gene Symbol: Wnt3a
Description: wingless-type MMTV integration site family, member 3A
Alias: Wnt-3a, protein Wnt-3a, vestigial tail, wingless-related MMTV integration site 3A
Species: mouse

Top Publications

  1. ncbi Lipocalin 24p3 is regulated by the Wnt pathway independent of regulation by iron
    Slava Ziegler
    Max Planck Institut fur molekulare Physiologie, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Cancer Genet Cytogenet 174:16-23. 2007
  2. ncbi The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
    A P McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 69:581-95. 1992
  3. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
  4. pmc Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
    Luca Grumolato
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Genes Dev 24:2517-30. 2010
  5. pmc Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:12747-52. 2003
  6. ncbi Wnt proteins are lipid-modified and can act as stem cell growth factors
    Karl Willert
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 423:448-52. 2003
  7. pmc Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation
    Long Zhang
    Department of Molecular Cell Biology and Center for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Mol Biol Cell 22:1617-24. 2011
  8. pmc Arginine methylation of G3BP1 in response to Wnt3a regulates β-catenin mRNA
    Rama Kamesh Bikkavilli
    Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 124:2310-20. 2011
  9. ncbi Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts
    Aiko Nakashima
    Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 280:37660-8. 2005
  10. pmc DeltaNp73 regulates neuronal survival in vivo
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology Unit, Brussels, Belgium
    Proc Natl Acad Sci U S A 106:16871-6. 2009

Research Grants

Scientific Experts

Detail Information

Publications148 found, 100 shown here

  1. ncbi Lipocalin 24p3 is regulated by the Wnt pathway independent of regulation by iron
    Slava Ziegler
    Max Planck Institut fur molekulare Physiologie, Otto Hahn Strasse 11, 44227 Dortmund, Germany
    Cancer Genet Cytogenet 174:16-23. 2007
    ..Differential splicing of the 24p3R transcript, depending on the activation state of the Wnt pathway, may modify the function of 24p3...
  2. ncbi The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum
    A P McMahon
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Cell 69:581-95. 1992
    ..We suggest that functional redundancy between these two genes accounts for the lack of a caudal central nervous system phenotype...
  3. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  4. pmc Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors
    Luca Grumolato
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    Genes Dev 24:2517-30. 2010
    ..We demonstrate here that prototype canonical Wnt3a and noncanonical Wnt5a ligands specifically trigger completely unrelated endogenous coreceptors-LRP5/6 and Ror1/2, ..
  5. pmc Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
    Goncalo Castelo-Branco
    Laboratory of Molecular Neurobiology, Medical Biochemistry, and Biophysics, Karolinska Institute, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 100:12747-52. 2003
    ..These findings indicate that Wnts are key regulators of proliferation and differentiation of DA precursors during VM neurogenesis and that different Wnts have specific and unique activity profiles...
  6. ncbi Wnt proteins are lipid-modified and can act as stem cell growth factors
    Karl Willert
    Howard Hughes Medical Institute and Department of Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 423:448-52. 2003
    ..Here we have isolated active Wnt molecules, including the product of the mouse Wnt3a gene. By mass spectrometry, we found the proteins to be palmitoylated on a conserved cysteine...
  7. pmc Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation
    Long Zhang
    Department of Molecular Cell Biology and Center for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Mol Biol Cell 22:1617-24. 2011
    ..These results identify FAF1 as a novel inhibitory factor of canonical Wnt signaling pathway...
  8. pmc Arginine methylation of G3BP1 in response to Wnt3a regulates β-catenin mRNA
    Rama Kamesh Bikkavilli
    Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 124:2310-20. 2011
    Wnt/β-catenin signaling is essential for normal mammalian development. Wnt3a activates the Wnt/β-catenin pathway through stabilization of β-catenin; a process in which the phosphoprotein Dishevelled figures prominently...
  9. ncbi Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts
    Aiko Nakashima
    Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
    J Biol Chem 280:37660-8. 2005
    ..To assess the contribution of Wnt, we generated C2C12 cells over-expressing Wnt3a or Wnt5a and treated these with BMP-2...
  10. pmc DeltaNp73 regulates neuronal survival in vivo
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology Unit, Brussels, Belgium
    Proc Natl Acad Sci U S A 106:16871-6. 2009
    ..However, ablation of cells that express DeltaNp73 and Wnt3a did neither remove all CRc, nor did they abolish Reelin secretion or generate a reeler-like cortical phenotype...
  11. doi Cdx2 regulation of posterior development through non-Hox targets
    Joanne G A Savory
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    Development 136:4099-110. 2009
    ..with attenuated expression of genes encoding several key players in axial elongation, including Fgf8, T, Wnt3a and Cyp26a1, and we present data suggesting that T, Wnt3a and Cyp26a1 are direct Cdx2 targets...
  12. ncbi The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium
    Joel Weidenfeld
    Department of Medicine, Molecular Cardiology Research Center, and the Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:21061-70. 2002
    ..Together, these results suggest that WNT7b gene expression in the lung epithelium is regulated in a combinatorial fashion by TTF-1, GATA6, and Foxa2...
  13. doi p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta
    Rama Kamesh Bikkavilli
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 121:3598-607. 2008
    ..kinase (MAPK) pathways that might intersect with the canonical Wnt-beta-catenin signaling pathway in response to Wnt3a, we observed a strong activation of p38 MAPK in mouse F9 teratocarcinoma cells...
  14. ncbi Mechanisms of Wnt signaling in development
    A Wodarz
    Institut fur Genetik, Universitat Dusseldorf, Germany
    Annu Rev Cell Dev Biol 14:59-88. 1998
    ..Here we review recent data that have started to unravel the mechanisms of Wnt signaling...
  15. ncbi Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
    Josipa Bilic
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 316:1619-22. 2007
    ..We propose that Wnts induce coclustering of receptors and Dvl in LRP6-signalosomes, which in turn triggers LRP6 phosphorylation to promote Axin recruitment and beta-catenin stabilization...
  16. pmc Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord
    Yuko Muroyama
    Kondoh Differentiation Signaling Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Corporation JST, Kinki Invention Center, Sakyo ku, Kyoto 606 8305, Japan
    Genes Dev 16:548-53. 2002
    ..Here, we demonstrate that absence of Wnt1 and Wnt3a, normally expressed in the roof plate, leads to diminished development of D1 and D2 neurons and a compensatory ..
  17. pmc Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth
    Yoshimi Endo Greer
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 192:993-1004. 2011
    ..These results provide strong evidence that the centrosomal localization of CK1δ is required for Wnt-3a-dependent neuritogenesis...
  18. pmc Wnt-dependent assembly of supermolecular Dishevelled-3-based complexes
    Noriko Yokoyama
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 123:3693-702. 2010
    ..4 to 2.0 MDa. Addition of Wnt3a stimulates the formation of Dvl3-based complexes of greater molecular mass within 30 minutes...
  19. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation...
  20. ncbi Wnt signaling controls the timing of oligodendrocyte development in the spinal cord
    Takeshi Shimizu
    Laboratory of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki National Research Institute, Nishigonaka, Myodaiji, Okazaki, Aichi 444 8585, Japan
    Dev Biol 282:397-410. 2005
    ..Addition of rmFz-8/Fc, a Wnt antagonist, increased the number of immature oligodendrocytes in the spinal cord explant culture, demonstrating that endogenous Wnt signaling controls oligodendrocyte development...
  21. ncbi The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice
    E A Grove
    Department of Pharmacological and Physiological Sciences, University of Chicago, Chicago, IL, USA
    Development 125:2315-25. 1998
    ..By contrast, three others, Wnt3a, 5a and a novel mouse Wnt gene, Wnt2b, are expressed only at the medial edge of the telencephalon, defining the ..
  22. ncbi Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT
    Maria Almeida
    Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Health Care System, Little Rock, Arkansas 72205, USA
    J Biol Chem 280:41342-51. 2005
    ..Serum withdrawal-induced apoptosis was prevented by the canonical Wnts (Wnt3a and Wnt1) and the noncanonical Wnt5a in all cell types...
  23. ncbi FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    B Ciruna
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Dev Cell 1:37-49. 2001
    ..Finally, we provide evidence that the attenuation of Wnt3a signaling observed in Fgfr1 -/- embryos can be rescued by lowering E-cadherin levels...
  24. pmc Down-regulation of chondroitin 4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a
    Satomi Nadanaka
    Department of Biochemistry, Kobe Pharmaceutical University, Kobe 658 8558, Japan
    J Biol Chem 286:4199-208. 2011
    ..These results demonstrated that C4ST-1 is a key downstream target of Wnt signaling that regulates Wnt diffusion from Wnt-producing cells...
  25. ncbi A local Wnt-3a signal is required for development of the mammalian hippocampus
    S M Lee
    Department of Molecular Biology, The Biolabs, Harvard University, Cambridge, MA 02138, USA
    Development 127:457-67. 2000
    ..Thus, Wnt-3a signaling is crucial for the normal growth of the hippocampus. We suggest that the coordination of growth with patterning may be a general role for Wnts during vertebrate development...
  26. pmc Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate
    Vishakha S Mangale
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Science 319:304-9. 2008
    ..In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer...
  27. pmc α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice
    Amparo Girós
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
    PLoS ONE 6:e22002. 2011
    ..Thus, α5β1-mediated adhesion to FN in the PSM regulates the dynamics of membrane protrusions and cell-to-cell communication essential for elongation and segmentation of the body axis...
  28. ncbi Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression
    Ju Suk Nam
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 281:13247-57. 2006
    ..Our findings expand the repertoire of ligands that induce beta-catenin/TCF-dependent gene activation and implicate the presence of active beta-catenin-dependent gene activation in a Wnt-free biological context...
  29. ncbi Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos
    P Rashbass
    National Institute for Medical Research, London, United Kingdom
    Int J Dev Biol 38:35-44. 1994
    ..This extension into ventromedial somite domains is more pronounced caudally, supporting a function for the notochord in ventralizing somites...
  30. pmc Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways
    Vinicio A de Jesus Perez
    Department of Medicine, Stanford University, Stanford, CA 94305, USA
    J Cell Biol 184:83-99. 2009
    ..These findings suggest that the recruitment of both canonical and noncanonical Wnt pathways is required in BMP-2-mediated angiogenesis...
  31. pmc Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy
    Suranga P Kodithuwakku
    Department of Obstetrics and Gynaecology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Lab Invest 92:256-64. 2012
    ..2-5 μg/ml) suppressed spheroid attachment to OE-E6/E7 cells, while activation of Wnt-signaling pathway by Wnt3a or LiCl reduced endogenous Olfm-1 expression and increased spheroid attachment...
  32. pmc The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures
    S Abu-Abed
    Cancer Research Labs, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Genes Dev 15:226-40. 2001
    ....
  33. ncbi Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
    Andrew W Duncan
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 6:314-22. 2005
    ..These data suggest that Notch signaling has a dominant function in inhibiting differentiation and provide a model for how HSCs may integrate multiple signals to maintain the stem cell state...
  34. pmc Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin
    José M González-Sancho
    Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:4757-68. 2004
    ..Our data also present Dvl phosphorylation as a general biochemical assay for Wnt protein function, including those Wnts that do not activate the Wnt/beta-catenin pathway...
  35. ncbi Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos
    Heiko Lickert
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Development 132:2599-609. 2005
    ..This functional genomic approach allows the rapid identification of functionally important components of embryonic development from large datasets of putative targets...
  36. pmc Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression
    J Galceran
    Gene Center and Institute of Biochemistry, University of Munich, Feodor Lynenstrasse 25, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 98:8668-73. 2001
    ..Consistent with this view, mice carrying mutations in either the Wnt3a gene or in both transcription factor genes Lef1 and Tcf1 were previously found to show a similar defect in the ..
  37. pmc Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice
    J Galceran
    Howard Hughes Medical Institute and Departments of Microbiology and Biochemistry, University of California, San Francisco, California 94143, USA
    Genes Dev 13:709-17. 1999
    ..paraxial mesoderm and lead to the formation of additional neural tubes, phenotypes identical to those reported for Wnt3a-deficient mice...
  38. doi Wnt/beta-catenin signaling suppresses Rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junction
    Jia Wang
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, China
    J Biol Chem 283:21668-75. 2008
    ..Here we report that Wnt3a negatively regulates acetylcholine receptor (AChR) clustering by repressing the expression of Rapsyn, an AChR-..
  39. doi Lymphoid enhancer factor 1-mediated Wnt signaling promotes the initiation of trophoblast lineage differentiation in mouse embryonic stem cells
    Shuyang He
    Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA
    Stem Cells 26:842-9. 2008
    ..Overexpression and RNA interference knockdown studies indicate that Cdx2 induction in response to Wnt3a is mediated by lymphoid enhancer factor 1, whose expression is regulated by leukemia inhibitory factor (LIF) and ..
  40. ncbi An LDL-receptor-related protein mediates Wnt signalling in mice
    K I Pinson
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Nature 407:535-8. 2000
    ..Furthermore, we show a genetic enhancement of a Wnt mutant phenotype in mice lacking one functional copy of LRP6. Together, our results support a broad role for LRP6 in the transduction of several Wnt signals in mammals...
  41. ncbi Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism
    T Reya
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA
    Immunity 13:15-24. 2000
    ..Finally, we establish a link between Wnt signaling and normal B cell development by demonstrating that Wnt proteins are mitogenic for pro-B cells and that this effect is mediated by LEF-1...
  42. doi R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression
    Wenyan Lu
    Department of Biochemistry and Molecular Biology, Drug Discovery Division, Southern Research Institute, Birmingham, AL 35255, USA
    FEBS Lett 582:643-50. 2008
    ..We reported herein that R-sponin1 (Rspo1) acted synergistically with Wnt3A to activate Wnt/beta-catenin signaling in the uncommitted mesenchymal C2C12 cells...
  43. ncbi The role of presenilin 1 during somite segmentation
    K Koizumi
    Department of Molecular Embryology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Development 128:1391-402. 2001
    ..In summary, we propose that Ps1 is involved in the functional manifestation of the segmentation clock in the presomitic mesoderm...
  44. ncbi Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response
    A Gazit
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Oncogene 18:5959-66. 1999
    ..All of these findings provide strong evidence that Hfz1 is a functional partner for certain Wnts in inducing TCF dependent transcription...
  45. ncbi Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression
    H Esterbauer
    Department of Laboratory Medicine, Landeskliniken Salzburg, Salzburg, Austria
    Genomics 62:98-102. 1999
    ..Hence, PPARGC1 expression might influence insulin sensitivity as well as energy expenditure, thereby contributing to the development and pathophysiology of human obesity...
  46. ncbi Antisense attenuation of Wnt-1 and Wnt-3a expression in whole embryo culture reveals roles for these genes in craniofacial, spinal cord, and cardiac morphogenesis
    K Augustine
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill 27599
    Dev Genet 14:500-20. 1993
    ....
  47. ncbi Biochemical analysis of murine Wnt proteins reveals both shared and distinct properties
    L W Burrus
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Exp Cell Res 220:363-73. 1995
    ..Whereas addition of suramin to COS cell cultures significantly increases the levels of all six Wnts in the medium, the addition of heparin only influences the levels of Wnt-1, Wnt-6, and Wnt-7b...
  48. ncbi Regulation of matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1 gene expression by WNT3A and bone morphogenetic protein-2 in osteoblastic differentiation
    Aiko Nakashima
    Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, 060 8586, Japan
    Front Biosci 11:1667-78. 2006
    ..To assess the functional contribution of Wnt signaling, we have generated C2C12 cell lines stably over-expressing Wnt3a or Wnt5a, and then treated these cells with BMP-2 for 24 h...
  49. ncbi Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid
    R Verani
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Neurochem 100:242-50. 2007
    ..These data suggest that induction of Dkk-1 and the ensuing inhibition of the canonical Wnt pathway is required for neural differentiation of ES cells...
  50. pmc Wnt3a links left-right determination with segmentation and anteroposterior axis elongation
    Masa aki Nakaya
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH Frederick, MD 21702, USA
    Development 132:5425-36. 2005
    ..How morphogenesis is coupled to axis specification is not well understood. We demonstrate that Wnt3a is required for LR asymmetry...
  51. ncbi R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants
    Tomoyuki Kamata
    Department of Neurology and Neurological Science, Graduate School of Tokyo Medical and Dental University, Japan
    Biochim Biophys Acta 1676:51-62. 2004
    ..R-spondin might be a novel marker of the boundary between the roof plate and neuroepithelium and may contribute to the development of dorsal neural tube under the regulation of Wnts...
  52. doi Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate
    Satomi Nadanaka
    Department of Biochemistry, Kobe Pharmaceutical University, Kobe 658 8558, Japan
    J Biol Chem 283:27333-43. 2008
    ..These results suggest that CS-E-like structures synthesized by C4ST-1 participate in Wnt-3a signaling and modulate the physiological events caused by Wnt-3a signals...
  53. pmc Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis
    Ryan R Driskell
    Department of Anatomy and Cell Biology, Iowa City, IA 52242, USA
    Dev Biol 305:90-102. 2007
    ..In the present study, we hypothesized that Wnt3a directly regulates Lef-1 gene expression required for SMG morphogenesis in mice...
  54. pmc PDZRN3 negatively regulates BMP-2-induced osteoblast differentiation through inhibition of Wnt signaling
    Takeshi Honda
    Department of Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755 8505, Japan
    Mol Biol Cell 21:3269-77. 2010
    ..Furthermore, the expression and Wnt3a-induced phosphorylation of LRP6 as well as the increase in the cytosolic abundance of β-catenin induced by Wnt3a ..
  55. doi MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial pallium
    Mikihito Shibata
    Laboratory for Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Chuo Ku, Kobe 650 0046, Japan
    J Neurosci 28:10415-21. 2008
    ..In addition, inhibition of endogenous miR-9 function by antisense oligonucleotides caused the regression of Wnt3a-positive cortical hem and reduction of reelin-, p73-, and NeuroD1-positive cells.
  56. ncbi Wnt signaling promotes regeneration in the retina of adult mammals
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    J Neurosci 27:4210-9. 2007
    ..b>Wnt3a treatment increases proliferation of dedifferentiated Müller glia >20-fold in the photoreceptor-damaged retina...
  57. ncbi Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation
    William C Dunty
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH, Frederick, MD 21702, USA
    Development 135:85-94. 2008
    Somitogenesis is thought to be controlled by a segmentation clock, which consists of molecular oscillators in the Wnt3a, Fgf8 and Notch pathways...
  58. pmc Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context
    Amanda J Mikels
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Biol 4:e115. 2006
    ..We find that purified Wnt5a inhibits Wnt3a protein-induced canonical Wnt signaling in a dose-dependent manner, not by influencing beta-catenin levels but by ..
  59. ncbi A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells
    Zhongyu Liu
    Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Biol Chem 281:17156-63. 2006
    ..Treatment with Wnt3a, but not BMP-2, stimulated Lef1-mediated transcriptional activity, whereas co-stimulation with both Wnt3a and BMP-..
  60. ncbi Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression
    Roberto Alvarez-Medina
    Instituto de Biologia Molecular de Barcelona, CSIC, Parc Cientific de Barcelona, C Josep Samitier 1 5, Barcelona 08028, Spain
    Development 135:237-47. 2008
    ..Here, we show that Wnt1/Wnt3a, by signalling through the canonical beta-catenin/Tcf pathway, control expression of dorsal genes and suppression ..
  61. pmc Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism
    Yoshimi Endo
    National Cancer Institute, Bldg 37, Room 2042, 37 Convent Drive, MSC 4256, Bethesda, MD 20892 4256, USA
    Mol Cell Biol 28:2368-79. 2008
    ..Our data demonstrate that Fzd3, Dvl, and JNK activity mediate Wnt-dependent neurite outgrowth and that ESFT cell lines will be useful experimental models for the study of Wnt-dependent neurite extension...
  62. ncbi Wnt3a binds to several sFRPs in the nanomolar range
    Danuta Wawrzak
    Laboratory for Cell Genetics, Vrije Universiteit Brussel VUB, Pleinlaan 2, B 1050 Brussels, Belgium
    Biochem Biophys Res Commun 357:1119-23. 2007
    ..show, using surface plasmon resonance and purified proteins, that sFRP1, sFRP2, sFRP4, and Frzb bind directly to Wnt3a with affinities in the nanomolar range...
  63. ncbi Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2
    Yoshimi Endo
    Laboratories of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:777-86. 2005
    ..Specific knock-down of Dvl-2 expression markedly reduced Wnt-3a-dependent changes in cell shape and movement, suggesting that this Dvl isoform had a predominant role in mediating Wnt-3a-dependent motility in Chinese hamster ovary cells...
  64. ncbi Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth
    Wange Lu
    California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA
    Cell 119:97-108. 2004
    ..Thus, Ryk appears to play a crucial role in Wnt-mediated signaling...
  65. ncbi Wnt-3a regulates somite and tailbud formation in the mouse embryo
    S Takada
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:174-89. 1994
    ..We suggest that dysmorphology is secondary to the mesodermal and axial defects and that dorsal patterning of the CNS may be regulated by inductive signals arising from surface ectoderm...
  66. ncbi Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
    K L Goh
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 124:4309-19. 1997
    ....
  67. ncbi Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds
    B A Parr
    Department of Cell and Developmental Biology, Roche Institute of Molecular Biology, Nutley, NJ 07110
    Development 119:247-61. 1993
    ..We discuss the significance of these patterns of restricted and partially overlapping domains of expression with respect to the putative function of Wnt signalling in early CNS and limb development...
  68. ncbi Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon
    Thomas Theil
    Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Development 129:3045-54. 2002
    ..These results establish Emx2 as a direct transcriptional target of Wnt and Bmp signalling and provide insights into a genetic hierarchy involving Gli3, Emx2 and Bmp and Wnt genes in the control of dorsal telencephalic development...
  69. ncbi Expression patterns of Wnt genes in mouse gut development
    H Lickert
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D 79108, Freiburg, Germany
    Mech Dev 105:181-4. 2001
    ..5. Wnt11 is highly expressed at the gastro-esophageal junctions, while Wnt4 is found in the epithelium lining the pyloric region of the stomach but not in the epithelium of the prospective gland region...
  70. pmc T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification
    T P Yamaguchi
    Department of Molecular Biology, Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:3185-90. 1999
    b>Wnt3a encodes a signal that is expressed in the primitive streak of the gastrulating mouse embryo and is required for paraxial mesoderm development. In its absence cells adopt ectopic neural fates...
  71. ncbi Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway
    J S Lee
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 274:21464-70. 1999
    ..These results are direct evidence that Dsh family proteins mediate a set of conserved biochemical processes in the Wnt/Wg signaling pathway...
  72. ncbi Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube
    H Roelink
    Howard Hughes Medical Institute, Beckman Center, Stanford University, California 94305
    Genes Dev 5:381-8. 1991
    ..Characteristic expression patterns of these two closely related genes suggest that Wnt-3 and Wnt-3A play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube...
  73. ncbi Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression
    M Ikeya
    Center for Molecular and Developmental Biology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo ku, 606 8502, Kyoto, Japan
    Mech Dev 103:27-33. 2001
    ..These results indicate that Wnt-3a is necessary for correct anteroposterior patterning of vertebra, and that cdx-1 may be one of the mediator genes of Wnt-3a signaling in this process...
  74. ncbi Wnt3a plays a major role in the segmentation clock controlling somitogenesis
    Alexander Aulehla
    Abteilung Entwicklungsbiologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
    Dev Cell 4:395-406. 2003
    ..Moreover, Wnt3a is required for oscillating Notch signaling activity in the PSM...
  75. doi Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages
    Jan Neumann
    Division of Microbial Interface Biology, Research Center Borstel, Borstel, Germany
    FASEB J 24:4599-612. 2010
    ..tuberculosis that was synergistically enhanced in the presence of IFN-γ. Addition of the Fzd1 ligand Wnt3a induced Wnt/β-catenin signaling in murine macrophages that was inhibited in the presence of a soluble Fzd1/Fc ..
  76. pmc Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain
    Cynthia L Andoniadou
    Neural Development Unit, UCL Institute of Child Health, 30 Guilford Street, WC1N 1EH, London, UK
    Development 134:1499-508. 2007
    ..However, conditional expression of Hesx1 within the AFB can rescue the forebrain defects observed in the Hesx1 mutants. The results presented here provide new insights into the function of Hesx1 in forebrain formation...
  77. ncbi A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo
    Q Tian Wang
    Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 6:133-44. 2004
    ..Overall, these data provide a detailed temporal profile of gene expression that reveals the richness of signaling processes in early mammalian development...
  78. pmc Contrasting responses of lymphoid progenitors to canonical and noncanonical Wnt signals
    Sachin Malhotra
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Immunol 181:3955-64. 2008
    ..We overexpressed Wnt3a, Wnt5a, and Dickkopf 1 in stromal cells from osteopetrotic mice and used them in coculture experiments with highly ..
  79. pmc Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension
    Xianling Zhao
    Burnham Institute for Medical Research, Development and Aging Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Gene Expr Patterns 9:430-5. 2009
    ..Following loss of RA signaling, the caudal expression domains of Fgf8, Wnt8a, and Wnt3a expand anteriorly into the trunk, but no change is observed in caudal expression of Fgf4 or Fgf17 plus caudal ..
  80. ncbi A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2)
    F J Probst
    Department of Human Genetics, University of Michigan, Ann Arbor 48109, USA
    Genomics 55:348-52. 1999
    ..The gene order in this region is not perfectly conserved between mouse and human, a finding to be considered as we engineer a mouse model of Smith-Magenis syndrome...
  81. ncbi The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation
    T Nagai
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Dev Biol 182:299-313. 1997
    ..Furthermore, analysis of gene expression patterns in different mouse mutants indicated that Zic genes may act upstream of many known developmental regulatory genes...
  82. ncbi Regulation of in vitro vascular calcification by BMP4, VEGF and Wnt3a
    Lyudmila Mikhaylova
    Department of Anatomy and Cell Biology, School of Medicine, Tufts University, Boston, MA 02111, USA
    Calcif Tissue Int 81:372-81. 2007
    ..In addition, these factors render VSMCs responsive to BMP4 and Wnt3a ligands...
  83. ncbi Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells
    Min Hu
    Department of Surgery, Stanford University School of Medicine, Stanford, California, USA
    Gastroenterology 133:1579-91. 2007
    ..Because Wnt/beta-catenin signaling is a known regulatory pathway for liver development and regeneration, we studied the role of Wnt signaling in oval cells using a mouse model of chronic liver injury...
  84. pmc FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a
    Lisa D Urness
    Department of Human Genetics, University of Utah, 15 N 2030 E, RM 2100, Salt Lake City, UT 84112 5330, USA
    Dev Biol 340:595-604. 2010
    ..Collectively, our results suggest that Wnt8a provides the link between FGF-induced formation of the pre-otic field and restriction of the otic placode to ectoderm adjacent to the hindbrain...
  85. doi Wnt3a promotes hippocampal neurogenesis by shortening cell cycle duration of neural progenitor cells
    Yutaka Yoshinaga
    Division of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo, Kumamoto, Japan
    Cell Mol Neurobiol 30:1049-58. 2010
    ..cells in the developing hippocampus, we prepared primary mouse hippocampal progenitors and treated them with Wnt3a in a chemically defined culture medium...
  86. pmc A Wnt- and beta -catenin-dependent pathway for mammalian cardiac myogenesis
    Teruya Nakamura
    Center for Cardiovascular Development and Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:5834-9. 2003
    ..Notably, Wnt3A and Wnt8A were induced days before even the earliest cardiogenic transcription factors...
  87. ncbi Spasmodic, a mutation on chromosome 11 in the mouse
    P W Lane
    Jackson Laboratory, Bar Harbor, ME 04609
    J Hered 78:353-6. 1987
    ..It is not an allele of spa and linkage tests show that this mutation is located close to vestigial tail (vt) near the center of chromosome 11...
  88. ncbi Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning
    Katrin Götz
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, Dusseldorf, Germany
    Dev Dyn 233:623-30. 2005
    ....
  89. ncbi Antisense targeting of engrailed-1 causes abnormal axis formation in mouse embryos
    T W Sadler
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill 27599, USA
    Teratology 51:292-9. 1995
    ..Thus, in addition to participating in the signaling pathway for brain and limb development, En-1 appears to play a role in patterning the embryonic axis...
  90. ncbi Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling
    Atsuhiko T Naito
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Circ Res 97:144-51. 2005
    ..These results suggest that the PI3K pathway regulates cardiomyocyte differentiation through suppressing the GSK-3beta activity and maintaining the Wnt/beta-catenin activity...
  91. ncbi The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family
    K Tanaka
    Graduate Program for Regulation of Biological Signals, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Eur J Biochem 267:4300-11. 2000
    ..These results demonstrate that the porc gene family encodes the multitransmembrane ER proteins, which are evolutionarily well conserved and involved in processing the Wnt family...
  92. pmc Growth differentiation factor 11 signaling controls retinoic acid activity for axial vertebral development
    Young Jae Lee
    Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Dev Biol 347:195-203. 2010
    ....
  93. ncbi Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1
    Suzan Abu-Abed
    Cancer Research Labs, Queen s University, Kingston, ON K7L 3N6, Canada
    Development 130:1449-59. 2003
    ..We also show that activated RARgamma results in downregulation of Wnt3a and Fgf8, which integrate highly conserved signaling pathways known for their role in specifying caudal ..
  94. ncbi Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation
    Mahua Mukhopadhyay
    Department of Anatomy, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Development 130:495-505. 2003
    ..The expression of several Wnt inhibitors is curtailed in the mutant, suggesting that Wnt pathways may be involved in axial patterning regulated by Ldb1...
  95. pmc Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice
    Stephen A Murray
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 103:10300-4. 2006
    ....
  96. doi Wnt-3a and Wnt-3 differently stimulate proliferation and neurogenesis of spinal neural precursors and promote neurite outgrowth by canonical signaling
    Monica D David
    Laboratori d Investigacio, Hospital Universitari Arnau de Vilanova, Departament de Ciencies Mediques Basiques, IRBLleida University of Lleida, Lleida, Spain
    J Neurosci Res 88:3011-23. 2010
    ..These findings may be of therapeutic interest for the treatment of neurodegenerative diseases and nerve injury...
  97. pmc Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus
    Krista K Bluske
    Department of Neuroscience, and Graduate Program in Neuroscience, Minneapolis, Minnesota 55455, USA
    Dev Dyn 238:3297-309. 2009
    ..Analysis of mice with enhanced or reduced Shh signal showed that Axin2 expression is similar to controls. These results suggest that differential Wnt signaling may play a role in patterning the thalamus independent of Shh signaling...
  98. ncbi Severe defects in the formation of epaxial musculature in open brain (opb) mutant mouse embryos
    R Spörle
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Saugetiergenetik, Neuherberg, Oberschleissheim, Germany
    Development 122:79-86. 1996
    ..The implications of our findings for interactions between dorsal neural tube, surface ectoderm and dorsomedial somite regions in specifying epaxial musculature are discussed...
  99. ncbi A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells
    T W Austin
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    Blood 89:3624-35. 1997
    ..We conclude that WNTs stimulate the survival/proliferation of hematopoietic progenitors, demonstrating that WNTs comprise a novel class of hematopoietic cell regulators...
  100. pmc Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells
    Sachin Malhotra
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation and the Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Exp Hematol 37:19-30. 2009
    ..We now explore the influence of Wnt signaling on cellular adhesion molecule expression by bone marrow stromal and hematopoietic cells...
  101. doi Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion
    Frederic Lluis
    Telethon Institute of Genetics and Medicine, Via P Castellino, 111, 80131 Naples, Italy
    Cell Stem Cell 3:493-507. 2008
    ..We show here that cyclic activation of Wnt/beta-catenin signaling in ESCs with Wnt3a or the glycogen synthase kinase-3 (GSK-3) inhibitor 6-bromoindirubin-3'-oxime (BIO) strikingly enhances the ..

Research Grants4

  1. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
    ..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
  2. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2008
    ..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..
  3. Damage and regeneration in the hematopoietic system
    Tannishtha Reya; Fiscal Year: 2009
    ..Furthermore, understanding the basis of impaired regeneration in the aging hematopoietic system may allow us to design novel means to improve the health and quality of life of aging patients. ..
  4. Regulation of Hematopoietic Stem Cell Self-Renewal
    Tannishtha Reya; Fiscal Year: 2010
    ..abstract_text> ..