wasted

Summary

Gene Symbol: wasted
Description: eukaryotic translation elongation factor 1 alpha 2
Alias: Eef1a, wasted, wst, elongation factor 1-alpha 2, EF-1-alpha-2, eEF1A-2, eukaryotic elongation factor 1 A-2, statin-S1
Species: mouse

Top Publications

  1. ncbi Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress
    Ruying Chang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 100:267-78. 2007
  2. pmc The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 gene
    D M Chambers
    Human Genetics Unit, Department of Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 95:4463-8. 1998
  3. ncbi Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice
    A Khalyfa
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 276:22915-22. 2001
  4. pmc Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis
    Louis Bruno Ruest
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, The Department of Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 277:5418-25. 2002
  5. ncbi Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer
    Nisha Anand
    Hamilton Regional Cancer Centre, Room 450, 699 Concession Street, Hamilton, Ontario, L8V 5C2, Canada
    Nat Genet 31:301-5. 2002
  6. ncbi 'Wasted', a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia
    L D Shultz
    Nature 297:402-4. 1982
  7. ncbi Translation elongation factor eEF1A2 is essential for post-weaning survival in mice
    H J Newbery
    Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 282:28951-9. 2007
  8. doi The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Int J Cancer 123:1573-85. 2008
  9. ncbi Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor
    Helen J Newbery
    Medical Genetics, Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neuropathol Exp Neurol 64:295-303. 2005
  10. pmc In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy
    Jennifer Doig
    Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK
    FEBS J 280:6528-40. 2013

Research Grants

Scientific Experts

  • Richard W Tsika
  • P Kristensen
  • Helen J Newbery
  • Catherine M Abbott
  • Jennifer Doig
  • Lowri A Griffiths
  • Eugenia Wang
  • Manuela Piazzi
  • P Miura
  • Zhaoyang Li
  • Louis Bruno Ruest
  • Permphan Dharmasaroja
  • Juno Kim
  • C M Abbott
  • Tatsuo Kido
  • H J Newbery
  • Ruying Chang
  • C R Libertin
  • Takeshi Uchiumi
  • Jie Pan
  • G E Woloschak
  • Nisha Anand
  • Faith J C Davies
  • Maria Vera
  • David Peberdy
  • DAVID BROWNSTEIN
  • A Khalyfa
  • Faith C J Davies
  • J Peters
  • Charlotte E Squires
  • Antonia M D Churchhouse
  • Irene Faenza
  • William Blalock
  • Roberta Fiume
  • Alberto Bavelloni
  • M Holcik
  • Giulia Ramazzotti
  • Andrea Urbani
  • G Belanger
  • R Kothary
  • A Coriati
  • Adriana Zingone
  • Y De Repentigny
  • Dong Mi Shin
  • B J Jasmin
  • Alexander L Kovalchuk
  • Simona D'Aguanno
  • Lucio Cocco
  • Herbert C Morse
  • Nadir Mario Maraldi
  • Chen Feng Qi
  • J Lee
  • Wan Namkung
  • Min Goo Lee
  • Kyung Hwan Kim
  • Min Jae Jo
  • Sung Hee Lee
  • Joo Young Kim
  • Jae Seok Yoon
  • S L Green
  • X Llor
  • Yun Fai Chris Lau
  • J A Boyd
  • J H Bergmann
  • D H Loh
  • D Brownstein
  • Y Y Chau
  • J E O'Donoghue
  • V A L Tomlinson
  • M Potter
  • Tatsuo Shimada
  • Hiroto Izumi
  • Michihiko Kuwano
  • D M Chambers
  • Takakazu Sasaguri
  • Takao Fukuda
  • E Wang
  • Teruhisa Tsuzuki
  • Kimitoshi Kohno
  • Takanori Nakamura
  • Abbas Fotovati
  • M Hafezparast
  • Kohtaro Shibahara
  • Josephine Peters
  • Derek Thomson
  • Richard R Ribchester
  • Stephen B Wharton
  • Thomas H Gillingwater
  • Suying Xu
  • Lisa A Porter

Detail Information

Publications46

  1. ncbi Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress
    Ruying Chang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 100:267-78. 2007
    b>eEF1A-1 and eEF1A-2 are two isoforms of translation elongation factor eEF1A...
  2. pmc The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 gene
    D M Chambers
    Human Genetics Unit, Department of Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 95:4463-8. 1998
    We have identified the mutation responsible for the autosomal recessive wasted (wst) mutation of the mouse...
  3. ncbi Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice
    A Khalyfa
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 276:22915-22. 2001
    ..it was difficult to study the developmental expression patterns of these two peptide elongation factors 1A in wasted and wild-type mice...
  4. pmc Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosis
    Louis Bruno Ruest
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, The Department of Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 277:5418-25. 2002
    Peptide elongation factor eEF1A-2/S1, which shares 92% homology with eEF1A-1/EF-1alpha, is exclusively expressed in brain, heart, and skeletal muscle...
  5. ncbi Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer
    Nisha Anand
    Hamilton Regional Cancer Centre, Room 450, 699 Concession Street, Hamilton, Ontario, L8V 5C2, Canada
    Nat Genet 31:301-5. 2002
    ..Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer...
  6. ncbi 'Wasted', a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia
    L D Shultz
    Nature 297:402-4. 1982
  7. ncbi Translation elongation factor eEF1A2 is essential for post-weaning survival in mice
    H J Newbery
    Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 282:28951-9. 2007
    ..b>Wasted mice (wst/wst) have a 15...
  8. doi The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein
    Tatsuo Kido
    Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Int J Cancer 123:1573-85. 2008
    ..a yeast two-hybrid screen of a fetal gonadal cDNA library and identified the translation elongation factor eEF1A as a binding partner for TSPY at the SET/NAP domain...
  9. ncbi Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor
    Helen J Newbery
    Medical Genetics, Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neuropathol Exp Neurol 64:295-303. 2005
    b>Wasted (wst) is a spontaneous autosomal recessive mutation in which the gene encoding translation factor eEF1A2 is deleted...
  10. pmc In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy
    Jennifer Doig
    Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK
    FEBS J 280:6528-40. 2013
    ..eEF1A2-null mutant wasted mice develop an aggressive, early-onset form of neurodegeneration, but it is unknown whether the wasting results ..
  11. ncbi Purification and characterisation of a tissue specific elongation factor 1 alpha (EF-1 alpha 2) from rabbit muscle
    P Kristensen
    Department of Chemistry, University of Aarhus, Denmark
    Biochem Biophys Res Commun 245:810-4. 1998
    ....
  12. ncbi YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation
    Takeshi Uchiumi
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 281:40440-9. 2006
    ..These results demonstrate that YB-1 is involved in early mouse development, including neural tube closure and cell proliferation...
  13. ncbi Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway
    S Lee
    Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    Biochem Biophys Res Commun 203:1371-7. 1994
    ..These results indicate that mouse and man contain a second member of the EF-1 alpha gene family, the S1 gene. They also suggest that our result obtained in rat may be extrapolated to mouse and man...
  14. pmc Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype
    Richard W Tsika
    Department of Biochemistry, School of Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Biol Chem 283:36154-67. 2008
    ..These novel in vivo data support a role for TEAD-1 in modulating slow muscle gene expression...
  15. pmc Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function
    Lowri A Griffiths
    Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    PLoS ONE 7:e41917. 2012
    ..Deletion of eEF1A2 in mice gives rise to the neurodegenerative phenotype "wasted" (wst)...
  16. pmc Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas
    Zhaoyang Li
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    PLoS ONE 5:e10755. 2010
    ..High-level expression was also a feature of a subset of cell lines developed from mouse PCT and from the human MM...
  17. ncbi Wasted by an elongation factor
    M Hafezparast
    Neurogenetics Unit, Imperial College School of Medicine at St Mary s, London, UK
    Trends Genet 14:215-7. 1998
  18. ncbi The wst gene regulates multiple forms of thymocyte apoptosis
    M Potter
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 700 University Avenue, Toronto, Ontario, M5G 1A8, Canada
    Cell Immunol 188:111-7. 1998
    Mice homozygous for the autosomal recessive mutation Wasted (wst/wst) display a disease characterized by immunodeficiency, cerebellar dysfunction, and sensitivity of their hematopoeitic cells to gamma radiation...
  19. ncbi BRK/Sik expression in the gastrointestinal tract and in colon tumors
    X Llor
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago 60607, USA
    Clin Cancer Res 5:1767-77. 1999
    ..The BRK tyrosine kinase appears to play a role in signal transduction in the normal gastrointestinal tract, and its overexpression may be linked to the development of a variety of epithelial tumors...
  20. ncbi Animal models for motor neuron disease
    S L Green
    Department of Comparative Medicine, Stanford University School of Medicine, California, USA
    Lab Anim Sci 49:480-7. 1999
    ..This review summarizes important features of selected established animal models of MND: genetically engineered mice and inherited or spontaneously occurring MND in the murine, canine, and equine species...
  21. pmc eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts: Ser⁵³ is a novel substrate for protein kinase C βI
    Manuela Piazzi
    Cellular Signaling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mol Cell Proteomics 9:2719-28. 2010
    ..antibody were identified; among these, particular interest was given to eukaryotic elongation factor 1α (eEF1A)...
  22. pmc Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse development
    Jie Pan
    Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and Department of Medicine, McGill University, Montreal, Canada
    Brain Res Dev Brain Res 149:1-8. 2004
    ..By immunofluorescent labeling, we detected both homologues in the developing brains of wild-type and wasted mutant mice, carrying a deletion in the eEF1A-2/S1 gene; we found that brain expression of eEF1A-2/S1 protein is ..
  23. ncbi Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene
    C Luo
    Division of Cellular and Molecular Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Gene 180:29-36. 1996
    ..T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein...
  24. doi The utrophin A 5'-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2
    P Miura
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
    Hum Mol Genet 19:1211-20. 2010
    ..The trans-factors and signaling pathways driving skeletal-muscle specific IRES-mediated translation of utrophin A could provide unique targets for developing pharmacological-based DMD therapies...
  25. doi The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growth
    Juno Kim
    Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Lab Invest 89:867-74. 2009
    ..In this study, we investigated the roles of eukaryotic translation elongation factor 1 alpha (eEF1A) in alkalinization-induced cell growth...
  26. ncbi Expression of ZAP-70 gene in the developing thymus and various nonlymphoid tissues of embryonic and adult mice
    S A Ishijima
    Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
    Cell Immunol 165:278-83. 1995
    ..These findings have suggested that ZAP-70 plays an important role in growth, differentiation, and function of not only T cells but also nerve cells and several embryonic tissues...
  27. ncbi Cytogenetic characterization of radiosensitive mouse mutants
    P P Van Buul
    MGC, Department of Radiation Genetics and Chemical Mutagenesis, Leiden, The Netherlands
    Mutat Res 251:171-9. 1991
    ..Among the mutations studied, namely the contrasted allele of steel (Slcon), viable dominant spotting (Wc), wasted (wst), varitint-waddler (Va) and dystonia musculorum (dt) as well as MS/Ae mice, various iso-, hyper- or hypo-..
  28. ncbi Adenosine deaminase, Ada, is in mouse chromosome 2H3, and is not allelic with wasted, wst
    C M Abbott
    MRC Radiobiology Unit, Chilton, Didcot, U K
    Biochem Genet 29:537-44. 1991
    ..M., et al., Proc. Natl. Acad. Sci. USA 83:693, 1986), it had been suggested that wst was a low-activity allele of Ada, but this cannot be so because Ada and wst have been found to be nonallelic.
  29. pmc The wasted mutant mouse. II. Immunological abnormalities in a mouse described as a model of ataxia-telangiectasia
    D Kaiserlian
    Clin Exp Immunol 63:562-9. 1986
    ..Recently a wasted mutant mouse (wst) has been described as an animal model of AT...
  30. ncbi Effect of DNA-damaging agents on isolated spleen cells and lung fibroblasts from the mouse mutant "wasted," a putative animal model for ataxia-telangiectasia
    T Inoue
    Cancer Res 46:3979-82. 1986
    Spleen cells from control and wasted (wst) mice, a putative animal model for the human genetic disease ataxia-telangiectasia, were tested for inhibition of replicative (semiconservative) DNA synthesis after treatments with bleomycin, ..
  31. pmc Deficiency of adenosine deaminase in the wasted mouse
    C M Abbott
    Proc Natl Acad Sci U S A 83:693-5. 1986
    b>Wasted (wst) is a spontaneous mutation with autosomal recessive inheritance. Abnormally low levels of adenosine deaminase have been found in erythrocytes from the wasted mouse...
  32. ncbi Evaluation of the mouse mutant "wasted" as an animal model for ataxia telangiectasia. I. Age-dependent and tissue-specific effects
    H Tezuka
    Mutat Res 161:83-90. 1986
    The wasted mouse, an animal model proposed for the genetically transmitted human disease ataxia telangiectasia (AT), was examined for its biological, cytogenetic and biochemical properties...
  33. ncbi Lack of adenosine deaminase deficiency in the mutant mouse wasted
    J D Geiger
    FEBS Lett 208:431-4. 1986
    The possibility that the mutant mouse wasted (wst/wst) may serve as an animal model for studies of severe combined immunodeficiency disease (SCID) and the role of adenosine deaminase (ADA, EC 3.5.4...
  34. ncbi The wasted mutant mouse. I. An animal model of secretory IgA deficiency with normal serum IgA
    D Kaiserlian
    J Immunol 135:1126-31. 1985
    The wasted (wst) mutation was recently described as a spontaneous, recessive mutation leading to pathologic changes affecting both the neurologic and the immune systems of wst/wst homozygotes, which presented symptoms analogous to those ..
  35. ncbi Evaluations of wasted mouse fibroblasts and SV-40 transformed human fibroblasts as models of ataxia telangiectasia in vitro
    S K Nordeen
    Mutat Res 140:219-22. 1984
    Fibroblast cultures from wasted mice have been derived and the responses of these cultures to bleomycin treatment or gamma-irradiation have been examined...
  36. ncbi Subnormal albumin gene expression is associated with weight loss in immunodeficient/DNA-repair-impaired wasted mice
    C R Libertin
    Department of Medicine, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153
    J Am Coll Nutr 13:149-53. 1994
    Mice bearing the autosomal recessive mutation wst express a disease syndrome of immunodeficiency, neurologic dysfunction, increased sensitivity to the killing effects of ionizing radiation, and dramatic weight loss that begins at 21 days ..
  37. ncbi Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin
    D K Ann
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis 55455
    J Biol Chem 266:10429-37. 1991
    ..abstract truncated at 400 words)..
  38. ncbi Mutant mouse models of ALS
    A Messer
    Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany
    Neurobiol Aging 15:247-8. 1994
  39. ncbi Linkage mapping around the ragged (Ra) and wasted (wst) loci on distal mouse chromosome 2
    C Abbott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    Genomics 20:94-8. 1994
    ..Mice that are homozygous for the recessive mutation wasted (wst) appear normal until soon after weaning, but then develop tremors and ataxia, undergo atrophy of the thymus ..
  40. ncbi Cytokine and T-cell subset abnormalities in immunodeficient wasted mice
    C R Libertin
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153
    Mol Immunol 31:753-9. 1994
    b>Wasted mice bear an autosomal recessive mutation (wst/wst) that manifests itself in neurologic abnormalities, immunologic deficiency, and faulty DNA repair evident by 21 days of age...
  41. ncbi Mapping studies of the distal imprinting region of mouse chromosome 2
    J Peters
    MRC Radiobiology Unit, Didcot, Oxon, UK
    Genet Res 63:169-74. 1994
    ..2 cM from wasted, wst...
  42. ncbi Differential gene expression during early murine yolk sac development
    J Palis
    University of Rochester, Department of Pediatrics, New York, USA
    Mol Reprod Dev 42:19-27. 1995
    ..These results are consistent with the hypothesis that at E7.5, the yolk sac endoderm provides differentiated liver-like functions, while the newly developing extraembryonic mesoderm is still a largely undifferentiated tissue...
  43. ncbi Dysregulation of temperature and liver cytokine gene expression in immunodeficient wasted mice
    C R Libertin
    Department of Pathology, Loyola University Medical Center, Maywood Illinois 60153, USA
    Cell Immunol 169:62-6. 1996
    b>Wasted mice bear the spontaneous autosomal recessive mutation wst/wst; this genotype is associated with weight loss beginning at 21 days of age, neurologic dysfunction, immunodeficiency at mucosal sites, and increased sensitivity to the ..
  44. ncbi Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain
    J Mazella
    Institut de Pharmacologie Moleculaire et Cellulaire, Unité Propre de Recherche 411, Centre National de la Recherche Scientifique, Valbonne, France
    J Neurosci 16:5613-20. 1996
    ..It is expressed maximally in the cerebellum, hippocampus, piriform cortex, and neocortex of adult mouse brain...
  45. ncbi Temporal patterns of A-myb and B-myb gene expression during testis development
    K E Latham
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Oncogene 13:1161-8. 1996
    ....
  46. ncbi Regulation of thymus PCNA expression is altered in radiation-sensitive wasted mice
    G E Woloschak
    Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, IL 60439 4833, USA
    Carcinogenesis 17:2357-65. 1996
    Mice bearing the autosomal recessive mutation 'wasted' (wst/wst) express a disease syndrome characterized by neurologic dysfunction, immunodeficiency, and increased sensitivity to the killing effects of ionizing radiation relative to ..

Research Grants2

  1. EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTION
    Richard Tsika; Fiscal Year: 2008
    ..abstract_text> ..
  2. ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPE
    Richard Tsika; Fiscal Year: 2009
    ..abstract_text> ..