Genomes and Genes
Gene Symbol: wasted
Description: eukaryotic translation elongation factor 1 alpha 2
Alias: Eef1a, wasted, wst, elongation factor 1-alpha 2, EF-1-alpha-2, eEF1A-2, eukaryotic elongation factor 1 A-2, statin-S1
- Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stressRuying Chang
Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
J Cell Biochem 100:267-78. 2007b>eEF1A-1 and eEF1A-2 are two isoforms of translation elongation factor eEF1A...
- The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 geneD M Chambers
Human Genetics Unit, Department of Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
Proc Natl Acad Sci U S A 95:4463-8. 1998We have identified the mutation responsible for the autosomal recessive wasted (wst) mutation of the mouse...
- Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted miceA Khalyfa
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 276:22915-22. 2001..it was difficult to study the developmental expression patterns of these two peptide elongation factors 1A in wasted and wild-type mice...
- Peptide elongation factor eEF1A-2/S1 expression in cultured differentiated myotubes and its protective effect against caspase-3-mediated apoptosisLouis Bruno Ruest
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, The Department of Medicine, McGill University, Montreal, Quebec H3T 1E2, Canada
J Biol Chem 277:5418-25. 2002Peptide elongation factor eEF1A-2/S1, which shares 92% homology with eEF1A-1/EF-1alpha, is exclusively expressed in brain, heart, and skeletal muscle...
- Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancerNisha Anand
Hamilton Regional Cancer Centre, Room 450, 699 Concession Street, Hamilton, Ontario, L8V 5C2, Canada
Nat Genet 31:301-5. 2002..Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer...
- 'Wasted', a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasiaL D Shultz
Nature 297:402-4. 1982
- Translation elongation factor eEF1A2 is essential for post-weaning survival in miceH J Newbery
Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
J Biol Chem 282:28951-9. 2007..b>Wasted mice (wst/wst) have a 15...
- The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoproteinTatsuo Kido
Division of Cell and Developmental Genetics, Department of Medicine, Veterans Affairs Medical Center, University of California, San Francisco, CA 94121, USA
Int J Cancer 123:1573-85. 2008..a yeast two-hybrid screen of a fetal gonadal cDNA library and identified the translation elongation factor eEF1A as a binding partner for TSPY at the SET/NAP domain...
- Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factorHelen J Newbery
Medical Genetics, Molecular Medicine Center, University of Edinburgh, Western General Hospital, Edinburgh, UK
J Neuropathol Exp Neurol 64:295-303. 2005b>Wasted (wst) is a spontaneous autosomal recessive mutation in which the gene encoding translation factor eEF1A2 is deleted...
- In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophyJennifer Doig
Medical Genetics Section, Molecular Medicine Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, UK
FEBS J 280:6528-40. 2013..eEF1A2-null mutant wasted mice develop an aggressive, early-onset form of neurodegeneration, but it is unknown whether the wasting results ..
- Purification and characterisation of a tissue specific elongation factor 1 alpha (EF-1 alpha 2) from rabbit muscleP Kristensen
Department of Chemistry, University of Aarhus, Denmark
Biochem Biophys Res Commun 245:810-4. 1998....
- YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferationTakeshi Uchiumi
Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi ku, Kitakyushu 807 8555, Japan
J Biol Chem 281:40440-9. 2006..These results demonstrate that YB-1 is involved in early mouse development, including neural tube closure and cell proliferation...
- Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathwayS Lee
Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
Biochem Biophys Res Commun 203:1371-7. 1994..These results indicate that mouse and man contain a second member of the EF-1 alpha gene family, the S1 gene. They also suggest that our result obtained in rat may be extrapolated to mouse and man...
- Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotypeRichard W Tsika
Department of Biochemistry, School of Medicine, University of Missouri, Columbia, Missouri 65211, USA
J Biol Chem 283:36154-67. 2008..These novel in vivo data support a role for TEAD-1 in modulating slow muscle gene expression...
- Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal functionLowri A Griffiths
Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
PLoS ONE 7:e41917. 2012..Deletion of eEF1A2 in mice gives rise to the neurodegenerative phenotype "wasted" (wst)...
- Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomasZhaoyang Li
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
PLoS ONE 5:e10755. 2010..High-level expression was also a feature of a subset of cell lines developed from mouse PCT and from the human MM...
- Wasted by an elongation factorM Hafezparast
Neurogenetics Unit, Imperial College School of Medicine at St Mary s, London, UK
Trends Genet 14:215-7. 1998
- The wst gene regulates multiple forms of thymocyte apoptosisM Potter
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 700 University Avenue, Toronto, Ontario, M5G 1A8, Canada
Cell Immunol 188:111-7. 1998Mice homozygous for the autosomal recessive mutation Wasted (wst/wst) display a disease characterized by immunodeficiency, cerebellar dysfunction, and sensitivity of their hematopoeitic cells to gamma radiation...
- BRK/Sik expression in the gastrointestinal tract and in colon tumorsX Llor
Department of Molecular Genetics, University of Illinois College of Medicine, Chicago 60607, USA
Clin Cancer Res 5:1767-77. 1999..The BRK tyrosine kinase appears to play a role in signal transduction in the normal gastrointestinal tract, and its overexpression may be linked to the development of a variety of epithelial tumors...
- Animal models for motor neuron diseaseS L Green
Department of Comparative Medicine, Stanford University School of Medicine, California, USA
Lab Anim Sci 49:480-7. 1999..This review summarizes important features of selected established animal models of MND: genetically engineered mice and inherited or spontaneously occurring MND in the murine, canine, and equine species...
- eEF1A phosphorylation in the nucleus of insulin-stimulated C2C12 myoblasts: Ser⁵³ is a novel substrate for protein kinase C βIManuela Piazzi
Cellular Signaling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Mol Cell Proteomics 9:2719-28. 2010..antibody were identified; among these, particular interest was given to eukaryotic elongation factor 1α (eEF1A)...
- Immuno-characterization of the switch of peptide elongation factors eEF1A-1/EF-1alpha and eEF1A-2/S1 in the central nervous system during mouse developmentJie Pan
Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and Department of Medicine, McGill University, Montreal, Canada
Brain Res Dev Brain Res 149:1-8. 2004..By immunofluorescent labeling, we detected both homologues in the developing brains of wild-type and wasted mutant mice, carrying a deletion in the eEF1A-2/S1 gene; we found that brain expression of eEF1A-2/S1 protein is ..
- Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 geneC Luo
Division of Cellular and Molecular Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Gene 180:29-36. 1996..T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein...
- The utrophin A 5'-UTR drives cap-independent translation exclusively in skeletal muscles of transgenic mice and interacts with eEF1A2P Miura
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
Hum Mol Genet 19:1211-20. 2010..The trans-factors and signaling pathways driving skeletal-muscle specific IRES-mediated translation of utrophin A could provide unique targets for developing pharmacological-based DMD therapies...
- The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growthJuno Kim
Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
Lab Invest 89:867-74. 2009..In this study, we investigated the roles of eukaryotic translation elongation factor 1 alpha (eEF1A) in alkalinization-induced cell growth...
- Expression of ZAP-70 gene in the developing thymus and various nonlymphoid tissues of embryonic and adult miceS A Ishijima
Department of Pathology, Tokyo Metropolitan Institute of Gerontology, Japan
Cell Immunol 165:278-83. 1995..These findings have suggested that ZAP-70 plays an important role in growth, differentiation, and function of not only T cells but also nerve cells and several embryonic tissues...
- Cytogenetic characterization of radiosensitive mouse mutantsP P Van Buul
MGC, Department of Radiation Genetics and Chemical Mutagenesis, Leiden, The Netherlands
Mutat Res 251:171-9. 1991..Among the mutations studied, namely the contrasted allele of steel (Slcon), viable dominant spotting (Wc), wasted (wst), varitint-waddler (Va) and dystonia musculorum (dt) as well as MS/Ae mice, various iso-, hyper- or hypo-..
- Adenosine deaminase, Ada, is in mouse chromosome 2H3, and is not allelic with wasted, wstC M Abbott
MRC Radiobiology Unit, Chilton, Didcot, U K
Biochem Genet 29:537-44. 1991..M., et al., Proc. Natl. Acad. Sci. USA 83:693, 1986), it had been suggested that wst was a low-activity allele of Ada, but this cannot be so because Ada and wst have been found to be nonallelic.
- The wasted mutant mouse. II. Immunological abnormalities in a mouse described as a model of ataxia-telangiectasiaD Kaiserlian
Clin Exp Immunol 63:562-9. 1986..Recently a wasted mutant mouse (wst) has been described as an animal model of AT...
- Effect of DNA-damaging agents on isolated spleen cells and lung fibroblasts from the mouse mutant "wasted," a putative animal model for ataxia-telangiectasiaT Inoue
Cancer Res 46:3979-82. 1986Spleen cells from control and wasted (wst) mice, a putative animal model for the human genetic disease ataxia-telangiectasia, were tested for inhibition of replicative (semiconservative) DNA synthesis after treatments with bleomycin, ..
- Deficiency of adenosine deaminase in the wasted mouseC M Abbott
Proc Natl Acad Sci U S A 83:693-5. 1986b>Wasted (wst) is a spontaneous mutation with autosomal recessive inheritance. Abnormally low levels of adenosine deaminase have been found in erythrocytes from the wasted mouse...
- Evaluation of the mouse mutant "wasted" as an animal model for ataxia telangiectasia. I. Age-dependent and tissue-specific effectsH Tezuka
Mutat Res 161:83-90. 1986The wasted mouse, an animal model proposed for the genetically transmitted human disease ataxia telangiectasia (AT), was examined for its biological, cytogenetic and biochemical properties...
- Lack of adenosine deaminase deficiency in the mutant mouse wastedJ D Geiger
FEBS Lett 208:431-4. 1986The possibility that the mutant mouse wasted (wst/wst) may serve as an animal model for studies of severe combined immunodeficiency disease (SCID) and the role of adenosine deaminase (ADA, EC 3.5.4...
- The wasted mutant mouse. I. An animal model of secretory IgA deficiency with normal serum IgAD Kaiserlian
J Immunol 135:1126-31. 1985The wasted (wst) mutation was recently described as a spontaneous, recessive mutation leading to pathologic changes affecting both the neurologic and the immune systems of wst/wst homozygotes, which presented symptoms analogous to those ..
- Evaluations of wasted mouse fibroblasts and SV-40 transformed human fibroblasts as models of ataxia telangiectasia in vitroS K Nordeen
Mutat Res 140:219-22. 1984Fibroblast cultures from wasted mice have been derived and the responses of these cultures to bleomycin treatment or gamma-irradiation have been examined...
- Subnormal albumin gene expression is associated with weight loss in immunodeficient/DNA-repair-impaired wasted miceC R Libertin
Department of Medicine, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153
J Am Coll Nutr 13:149-53. 1994Mice bearing the autosomal recessive mutation wst express a disease syndrome of immunodeficiency, neurologic dysfunction, increased sensitivity to the killing effects of ionizing radiation, and dramatic weight loss that begins at 21 days ..
- Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statinD K Ann
Department of Pharmacology, Medical School, University of Minnesota, Minneapolis 55455
J Biol Chem 266:10429-37. 1991..abstract truncated at 400 words)..
- Mutant mouse models of ALSA Messer
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany
Neurobiol Aging 15:247-8. 1994
- Linkage mapping around the ragged (Ra) and wasted (wst) loci on distal mouse chromosome 2C Abbott
MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
Genomics 20:94-8. 1994..Mice that are homozygous for the recessive mutation wasted (wst) appear normal until soon after weaning, but then develop tremors and ataxia, undergo atrophy of the thymus ..
- Cytokine and T-cell subset abnormalities in immunodeficient wasted miceC R Libertin
Department of Pathology, Loyola University Medical Center, Maywood, IL 60153
Mol Immunol 31:753-9. 1994b>Wasted mice bear an autosomal recessive mutation (wst/wst) that manifests itself in neurologic abnormalities, immunologic deficiency, and faulty DNA repair evident by 21 days of age...
- Mapping studies of the distal imprinting region of mouse chromosome 2J Peters
MRC Radiobiology Unit, Didcot, Oxon, UK
Genet Res 63:169-74. 1994..2 cM from wasted, wst...
- Differential gene expression during early murine yolk sac developmentJ Palis
University of Rochester, Department of Pediatrics, New York, USA
Mol Reprod Dev 42:19-27. 1995..These results are consistent with the hypothesis that at E7.5, the yolk sac endoderm provides differentiated liver-like functions, while the newly developing extraembryonic mesoderm is still a largely undifferentiated tissue...
- Dysregulation of temperature and liver cytokine gene expression in immunodeficient wasted miceC R Libertin
Department of Pathology, Loyola University Medical Center, Maywood Illinois 60153, USA
Cell Immunol 169:62-6. 1996b>Wasted mice bear the spontaneous autosomal recessive mutation wst/wst; this genotype is associated with weight loss beginning at 21 days of age, neurologic dysfunction, immunodeficiency at mucosal sites, and increased sensitivity to the ..
- Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brainJ Mazella
Institut de Pharmacologie Moleculaire et Cellulaire, Unité Propre de Recherche 411, Centre National de la Recherche Scientifique, Valbonne, France
J Neurosci 16:5613-20. 1996..It is expressed maximally in the cerebellum, hippocampus, piriform cortex, and neocortex of adult mouse brain...
- Temporal patterns of A-myb and B-myb gene expression during testis developmentK E Latham
The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
Oncogene 13:1161-8. 1996....
- Regulation of thymus PCNA expression is altered in radiation-sensitive wasted miceG E Woloschak
Center for Mechanistic Biology and Biotechnology, Argonne National Laboratory, IL 60439 4833, USA
Carcinogenesis 17:2357-65. 1996Mice bearing the autosomal recessive mutation 'wasted' (wst/wst) express a disease syndrome characterized by neurologic dysfunction, immunodeficiency, and increased sensitivity to the killing effects of ionizing radiation relative to ..
- EXERCISE HYPERTROPHY AND CONTROL OF MYOSIN INDUCTIONRichard Tsika; Fiscal Year: 2008..abstract_text> ..
- ALTERED MECHANICAL LOADS AND SKELETAL MUSCLE PHENOTYPERichard Tsika; Fiscal Year: 2009..abstract_text> ..