wa3

Summary

Gene Symbol: wa3
Description: protein phosphatase 1, regulatory (inhibitor) subunit 13 like
Alias: AV260376, IASPP, Nkip1, wa3, relA-associated inhibitor, NFkB interacting protein 1, PPP1R13B-like protein, inhibitor of ASPP protein, ppp1r13l, protein iASPP
Species: mouse

Top Publications

  1. ncbi A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice
    Bruce J Herron
    Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:667-77. 2005
  2. pmc ASPP: a new family of oncogenes and tumour suppressor genes
    A Sullivan
    Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
    Br J Cancer 96:196-200. 2007
  3. pmc iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
    Anissa Chikh
    Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
    EMBO J 30:4261-73. 2011
  4. pmc Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification
    Mario Notari
    Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Proc Natl Acad Sci U S A 108:16645-50. 2011
  5. pmc Nuclear iASPP may facilitate prostate cancer progression
    E V Morris
    1 Ludwig Institute for Cancer Research Ltd, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building Off Roosevelt Drive, Headington, Oxford, UK 2 Nuffield Department of Surgical Sciences, University of Oxford, Old Road Campus Research Building Off Roosevelt Drive, Headington, Oxford, UK
    Cell Death Dis 5:e1492. 2014
  6. pmc iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death
    Mario Notari
    Ludwig Institute for Cancer Research Ltd, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Proc Natl Acad Sci U S A 112:E973-81. 2015
  7. pmc Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene
    Joseph Toonen
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    BMC Genet 13:76. 2012
  8. doi MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke
    Xiangrong Liu
    Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Key Laboratory of Neurodegenerative Diseases Capital Medical University, Ministry of Education, Beijing, China
    Stroke 44:1973-80. 2013
  9. pmc Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms
    Magdalena J Laska
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Mol Carcinog 48:832-42. 2009
  10. doi p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses
    Magdalena J Laska
    Institute of Human Genetics, Aarhus University, DK 8000 Aarhus C, Denmark
    Biochim Biophys Acta 1800:1231-40. 2010

Scientific Experts

  • Magdalena J Laska
  • Mario Notari
  • E V Morris
  • Xin Lu
  • Xiangrong Liu
  • Shan Zhong
  • Min Lu
  • Ying Hu
  • Joseph Toonen
  • Anissa Chikh
  • X Lu
  • A Sullivan
  • Bruce J Herron
  • Arash Yavari
  • Sofia de Noronha
  • Laurent Dupays
  • Kieran Clarke
  • David P Kelsell
  • Andrew Tinker
  • Mary N Sheppard
  • Aaisha Opel
  • Carolyn A Carr
  • Gopinath Sutendra
  • Zinaida Dedeic
  • Timothy J Mohun
  • David J P Ferguson
  • Hugh Watkins
  • Mike Hollinshead
  • I Ratnayaka
  • F C Hamdy
  • C Verrill
  • R J Bryant
  • C S ten Donkelaar
  • M J White
  • L Cerundolo
  • G N Thalmann
  • V Salter
  • F Fritzsche
  • M Lu
  • Jun Kang
  • Xunming Ji
  • Shangfeng Zhao
  • Yumin Luo
  • Sijie Li
  • Feng Yan
  • Fang Li
  • Haiping Zhao
  • Duska J Sidjanin
  • Lina Liang
  • Valentina Senatore
  • Giovanna Chiorino
  • Kristin M Braun
  • Eleonora Candi
  • Baki Akgul
  • Catherine A Harwood
  • Paola Ostano
  • Gerry Melino
  • Sahira Khalaf
  • Danielle Lavery
  • Martin Hufbauer
  • Chiara Ghimenti
  • Claudio Raimondi
  • Daniele Bergamaschi
  • Anna Pagotto
  • Michael P Philpott
  • Rubeta N H Matin
  • Adiam Bahta
  • Victoria Salter
  • Maurizia Mello-Grand
  • Robert Goldin
  • Caroline Baer
  • Indrika Ratnayaka
  • Sofia Koch
  • Sarah E Millar
  • Emily Olivieri
  • Shanming Liu
  • Lisa Laprade
  • James A Richardson
  • Cherie Rao
  • Lisa Stubbs
  • David R Beier
  • Chris Semsarian

Detail Information

Publications10

  1. ncbi A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice
    Bruce J Herron
    Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:667-77. 2005
    ..A C-terminal fragment of this protein was previously identified as the RelA associated inhibitor (RAI)...
  2. pmc ASPP: a new family of oncogenes and tumour suppressor genes
    A Sullivan
    Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
    Br J Cancer 96:196-200. 2007
    The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1)...
  3. pmc iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
    Anissa Chikh
    Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
    EMBO J 30:4261-73. 2011
    b>iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers...
  4. pmc Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification
    Mario Notari
    Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Proc Natl Acad Sci U S A 108:16645-50. 2011
    Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is the most ancient member of the ASPP family of proteins and an evolutionarily conserved inhibitor of p53. iASPP is also a binding partner and negative regulator of p65RelA...
  5. pmc Nuclear iASPP may facilitate prostate cancer progression
    E V Morris
    1 Ludwig Institute for Cancer Research Ltd, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building Off Roosevelt Drive, Headington, Oxford, UK 2 Nuffield Department of Surgical Sciences, University of Oxford, Old Road Campus Research Building Off Roosevelt Drive, Headington, Oxford, UK
    Cell Death Dis 5:e1492. 2014
    ..Here we identify inhibitor of apoptosis-stimulating protein of p53 (iASPP), a common cellular regulator of p53 and p63, as an important player of PCa progression...
  6. pmc iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death
    Mario Notari
    Ludwig Institute for Cancer Research Ltd, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
    Proc Natl Acad Sci U S A 112:E973-81. 2015
    ..5. iASPP-deficient mice with exon 8 deletion (Ppp1r13l(Δ8/Δ8)) die of sudden cardiac death, displaying features of ARVC...
  7. pmc Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene
    Joseph Toonen
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    BMC Genet 13:76. 2012
    ..The goals of this study were to phenotypically characterize the woe2 mice and to identify the gene harboring the mutation responsible for the woe2 phenotype...
  8. doi MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke
    Xiangrong Liu
    Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Key Laboratory of Neurodegenerative Diseases Capital Medical University, Ministry of Education, Beijing, China
    Stroke 44:1973-80. 2013
    ..we identified a novel microRNA mechanism that downregulation of inhibitory member of the apoptosis-stimulating proteins of p53 family (iASPP) by the brain-specific microRNA-124 (miR-124) promotes neuronal death after cerebral ischemia.
  9. pmc Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms
    Magdalena J Laska
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Mol Carcinog 48:832-42. 2009
    b>PPP1R13L was initially identified as a protein that binds to the NF-kappaB subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action...
  10. doi p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses
    Magdalena J Laska
    Institute of Human Genetics, Aarhus University, DK 8000 Aarhus C, Denmark
    Biochim Biophys Acta 1800:1231-40. 2010
    b>PPP1R13L gene has been found to be over-expressed in variety of cancers and its expression in p53 wild-type background is sufficient to promote tumor growth in vivo...