Genomes and Genes
Gene Symbol: wa3
Description: protein phosphatase 1, regulatory (inhibitor) subunit 13 like
Alias: AV260376, IASPP, Nkip1, wa3, relA-associated inhibitor, NFkB interacting protein 1, PPP1R13B-like protein, inhibitor of ASPP protein, ppp1r13l, protein iASPP
- A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 miceBruce J Herron
Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 14:667-77. 2005..A C-terminal fragment of this protein was previously identified as the RelA associated inhibitor (RAI)...
- ASPP: a new family of oncogenes and tumour suppressor genesA Sullivan
Ludwig Institute for Cancer Research, University College London, 91 Riding House Street, London W1W 7BS, UK
Br J Cancer 96:196-200. 2007The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1)...
- iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epitheliaAnissa Chikh
Centre for Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK
EMBO J 30:4261-73. 2011b>iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers...
- Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratificationMario Notari
Nuffield Department of Clinical Medicine, Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, United Kingdom
Proc Natl Acad Sci U S A 108:16645-50. 2011Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is the most ancient member of the ASPP family of proteins and an evolutionarily conserved inhibitor of p53. iASPP is also a binding partner and negative regulator of p65RelA...
- Nuclear iASPP may facilitate prostate cancer progressionE V Morris
1 Ludwig Institute for Cancer Research Ltd, University of Oxford, Nuffield Department of Clinical Medicine, Old Road Campus Research Building Off Roosevelt Drive, Headington, Oxford, UK 2 Nuffield Department of Surgical Sciences, University of Oxford, Old Road Campus Research Building Off Roosevelt Drive, Headington, Oxford, UK
Cell Death Dis 5:e1492. 2014..Here we identify inhibitor of apoptosis-stimulating protein of p53 (iASPP), a common cellular regulator of p53 and p63, as an important player of PCa progression...
- iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden deathMario Notari
Ludwig Institute for Cancer Research Ltd, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
Proc Natl Acad Sci U S A 112:E973-81. 2015..5. iASPP-deficient mice with exon 8 deletion (Ppp1r13l(Δ8/Δ8)) die of sudden cardiac death, displaying features of ARVC...
- Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) geneJoseph Toonen
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
BMC Genet 13:76. 2012..The goals of this study were to phenotypically characterize the woe2 mice and to identify the gene harboring the mutation responsible for the woe2 phenotype...
- MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental strokeXiangrong Liu
Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Key Laboratory of Neurodegenerative Diseases Capital Medical University, Ministry of Education, Beijing, China
Stroke 44:1973-80. 2013..we identified a novel microRNA mechanism that downregulation of inhibitory member of the apoptosis-stimulating proteins of p53 family (iASPP) by the brain-specific microRNA-124 (miR-124) promotes neuronal death after cerebral ischemia.
- Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanismsMagdalena J Laska
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
Mol Carcinog 48:832-42. 2009b>PPP1R13L was initially identified as a protein that binds to the NF-kappaB subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action...
- p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responsesMagdalena J Laska
Institute of Human Genetics, Aarhus University, DK 8000 Aarhus C, Denmark
Biochim Biophys Acta 1800:1231-40. 2010b>PPP1R13L gene has been found to be over-expressed in variety of cancers and its expression in p53 wild-type background is sufficient to promote tumor growth in vivo...