Vegfb

Summary

Gene Symbol: Vegfb
Description: vascular endothelial growth factor B
Alias: VEGF-B, Vrf, vascular endothelial growth factor B, VEGF-related factor
Species: mouse

Top Publications

  1. ncbi Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia
    D Bellomo
    QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, The Queensland Institute of Medical Research, Australia
    Circ Res 86:E29-35. 2000
  2. pmc VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats
    Yang Li
    National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland 20892, USA
    J Clin Invest 118:913-23. 2008
  3. pmc Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
  4. doi Vascular endothelial growth factor B controls endothelial fatty acid uptake
    Carolina E Hagberg
    Tissue Biology Group, Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nature 464:917-21. 2010
  5. doi Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
    Maija Bry
    Molecular Cancer Biology Laboratory and Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Circulation 122:1725-33. 2010
  6. doi Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
    Carolina E Hagberg
    Tissue Biology Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nature 490:426-30. 2012
  7. ncbi Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
    K Aase
    Ludwig Institute for Cancer Research, Stockholm Branch, Sweden
    Circulation 104:358-64. 2001
  8. doi The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands
    Andrey Anisimov
    Translational Cancer Biology Program, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, FIN 00014 Helsinki, Finland
    Sci Signal 6:ra52. 2013
  9. ncbi Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature
    K Aase
    Ludwig Institute for Cancer Research, Stockholm Branch, Sweden
    Dev Dyn 215:12-25. 1999
  10. pmc VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart
    Riikka Kivela
    Wihuri Research Institute and Translational Cancer Biology Research Program, University of Helsinki, Helsinki, Finland
    EMBO Mol Med 6:307-21. 2014

Scientific Experts

  • P Carmeliet
  • Masaubmi Shibuya
  • Janet C Wanstall
  • Jay L Vivian
  • J Lagercrantz
  • Kari Alitalo
  • Carolina E Hagberg
  • Ulf Eriksson
  • Riikka Kivela
  • Andrey Anisimov
  • Michael Jeltsch
  • Marius R Robciuc
  • Yan Qiu
  • Andrew Nash
  • Pierre Scotney
  • Xuri Li
  • Kory J Lavine
  • Maija Bry
  • Yihai Cao
  • Annelie Falkevall
  • Joke Dhondt
  • Sachie Hiratsuka
  • Yunjuan Sun
  • Seppo Yla-Herttuala
  • Koen Poesen
  • Arne W Mould
  • K Alitalo
  • Fan Zhang
  • Yang Li
  • Xiaojuan Yang
  • Hemabindu Chintala
  • Lauri Eklund
  • Veli Matti Leppänen
  • David A Greenberg
  • Victor H Guaiquil
  • M H Dijkstra
  • San Pin Wu
  • Anne Christine Hick
  • Rachel B Reinert
  • David M Ornitz
  • Juhani Knuuti
  • Indroneal Banerjee
  • B Olofsson
  • Eero Mervaala
  • Monique Y Rennie
  • Antti Saraste
  • Tanja Holopainen
  • Ming Xu
  • Jessica N Copeland
  • Keishi Kishimoto
  • Sharon Stone-Elander
  • Erik Samen
  • Katarzyna Furrer
  • Li Lu
  • Imke Albrecht
  • Kristian Pietras
  • K Aase
  • Tokumitsu Watanabe
  • Ming Hu
  • An Verheyen
  • Diether Lambrechts
  • Theo Meert
  • Rony Nuydens
  • Maarten Vanwildemeersch
  • Heather Bevan
  • Shui Hu Zhang
  • Johan Lennartsson
  • Nobuo Nagai
  • Zhongshu Tang
  • Kevin G Becker
  • Guo Hua Fong
  • Hao Ding
  • Olga Gealekman
  • Marc Tjwa
  • Xuling Huang
  • Minke van Tuyl
  • Kyunghee Choi
  • Fanxin Long
  • Napoleone Ferrara
  • Megan E Baldwin
  • Hans Peter Gerber
  • Ajay K Malik
  • Balamurali K Ambati
  • U Eriksson
  • Kenji Nakamura
  • Kunlin Jin
  • Motoya Katsuki
  • Jocelyn T Childs
  • Yoshiro Maru
  • Kazuki Nakao

Detail Information

Publications64

  1. ncbi Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia
    D Bellomo
    QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, The Queensland Institute of Medical Research, Australia
    Circ Res 86:E29-35. 2000
    ..To further study the in vivo function of VEGF-B, we have generated Vegfb knockout mice (Vegfb(-/-))...
  2. pmc VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats
    Yang Li
    National Eye Institute, NIH, Porter Neuroscience Research Center, Bethesda, Maryland 20892, USA
    J Clin Invest 118:913-23. 2008
    ..These findings indicate that VEGF-B may potentially offer a new therapeutic option for the treatment of neurodegenerative diseases...
  3. pmc Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium
    Xuri Li
    Vesalius Research Center, VIB, 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 28:1614-20. 2008
    ..The endogenous role of the VEGF family member vascular endothelial growth factor-B (VEGF-B) in pathological angiogenesis remains unclear...
  4. doi Vascular endothelial growth factor B controls endothelial fatty acid uptake
    Carolina E Hagberg
    Tissue Biology Group, Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nature 464:917-21. 2010
    ..Bioinformatic analysis showed that Vegfb was tightly co-expressed with nuclear-encoded mitochondrial genes across a large variety of physiological ..
  5. doi Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation
    Maija Bry
    Molecular Cancer Biology Laboratory and Institute for Molecular Medicine Finland, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Circulation 122:1725-33. 2010
    ..Vascular endothelial growth factor-B (VEGF-B) binds to VEGF receptor-1 and neuropilin-1 and is abundantly expressed in the heart, skeletal muscle, and brown fat. The biological function of VEGF-B is incompletely understood...
  6. doi Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes
    Carolina E Hagberg
    Tissue Biology Group, Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Nature 490:426-30. 2012
    ..Recently it was found that vascular endothelial growth factor B (VEGF-B) controls endothelial uptake and transport of fatty acids in heart and skeletal muscle...
  7. ncbi Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
    K Aase
    Ludwig Institute for Cancer Research, Stockholm Branch, Sweden
    Circulation 104:358-64. 2001
    ..One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart...
  8. doi The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands
    Andrey Anisimov
    Translational Cancer Biology Program, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, FIN 00014 Helsinki, Finland
    Sci Signal 6:ra52. 2013
    ....
  9. ncbi Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature
    K Aase
    Ludwig Institute for Cancer Research, Stockholm Branch, Sweden
    Dev Dyn 215:12-25. 1999
    b>Vascular endothelial growth factor B (VEGF-B) is structurally closely related to VEGF and binds one of its receptors, VEGFR-1...
  10. pmc VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart
    Riikka Kivela
    Wihuri Research Institute and Translational Cancer Biology Research Program, University of Helsinki, Helsinki, Finland
    EMBO Mol Med 6:307-21. 2014
    ..Our data indicate that VEGF-B could be used to increase the coronary vasculature and to reprogram myocardial metabolism to improve cardiac function in ischemic heart disease. ..
  11. pmc Vascular endothelial growth factor B, a novel growth factor for endothelial cells
    B Olofsson
    Ludwig Institute for Cancer Research, Stockholm, Sweden
    Proc Natl Acad Sci U S A 93:2576-81. 1996
    We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor...
  12. ncbi Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform
    B Olofsson
    Ludwig Institute for Cancer Research, Stockholm Branch, Box 240, S 171 77 Stockholm, Sweden
    J Biol Chem 271:19310-7. 1996
    A second isoform and the genomic structures of mouse and human vascular endothelial growth factor B are described. Both genes consist of seven coding exons and span about 4 kilobases of DNA...
  13. pmc Tbx18 regulates development of the epicardium and coronary vessels
    San Pin Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, United States Electronic address
    Dev Biol 383:307-20. 2013
    ....
  14. doi VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications
    Marius R Robciuc
    Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, 00290 Helsinki, Finland Electronic address
    Cell Metab 23:712-24. 2016
    ..Here, we report the unexpected finding that vascular endothelial growth factor B (VEGFB) gene transduction into mice inhibits obesity-associated inflammation and improves metabolic ..
  15. pmc Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets
    Rachel B Reinert
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee
    Diabetes 62:4154-64. 2013
    ..These results indicate that VEGF-A and islet vascularization have a lesser role in adult islet function and β-cell mass. ..
  16. doi Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation
    Anne Christine Hick
    de Duve Institute, Universite Catholique de Louvain UCL, B 1200 Brussels, Belgium
    Dev Biol 381:227-40. 2013
    ..In turn, endothelial cells control epithelial reorganization in follicles and C-cells differentiation...
  17. pmc Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice
    M H Dijkstra
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Sci Rep 4:6238. 2014
    ..We conclude that VEGF-B is dispensable for normal cardiac function under unstressed conditions and for HFD-induced metabolic changes. ..
  18. pmc VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions
    Victor H Guaiquil
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, NY 10065
    Proc Natl Acad Sci U S A 111:17272-7. 2014
    ..These selective effects of VEGF-B on injured nerves and its lack of angiogenic activity makes VEGF-B a suitable therapeutic target to treat nerve injury. ..
  19. pmc VEGF-B promotes cancer metastasis through a VEGF-A-independent mechanism and serves as a marker of poor prognosis for cancer patients
    Xiaojuan Yang
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Shanghai 200072, Republic of China
    Proc Natl Acad Sci U S A 112:E2900-9. 2015
    ..Taken together, our findings demonstrate that VEGF-B is a vascular remodeling factor promoting cancer metastasis and that targeting VEGF-B may be an important therapeutic approach for cancer metastasis. ..
  20. pmc The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling
    Hemabindu Chintala
    State University of New York SUNY Eye Institute and Department of Cell Biology, Downstate Medical Center, Brooklyn, NY 11203, USA
    Development 142:2364-74. 2015
    ..These data highlight novel functions of CCN1 as a naturally optimized molecule, fine-controlling key processes in physiological angiogenesis and safeguarding against aberrant angiogenic responses. ..
  21. pmc Overexpression of VEGF165b in podocytes reduces glomerular permeability
    Yan Qiu
    Microvascular Research Laboratories, Department Physiology and Pharmacology, Bristol Heart Institute, Preclinical Veterinary School, Southwell Street, Bristol, BS2 8EJ, UK
    J Am Soc Nephrol 21:1498-509. 2010
    ..These data highlight the contrasting properties of VEGF splice variants and their impact on glomerular function and phenotype...
  22. pmc Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice
    Sachie Hiratsuka
    Division of Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Cell Biol 25:346-54. 2005
    ..These results strongly suggest that the membrane-fixed ligand-binding region of VEGFR1 traps VEGF for the appropriate regulation of VEGF signaling in vascular endothelial cells during early embryogenesis...
  23. doi Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
    Koen Poesen
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    J Neurosci 28:10451-9. 2008
    ..The neuroprotective activity of VEGF-B, in combination with its negligible angiogenic/permeability activity, offers attractive opportunities for the treatment of neurodegenerative diseases...
  24. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
    ....
  25. doi Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation
    Keishi Kishimoto
    Department of Molecular Biology, Graduate School of Pharmaceutical Science, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi, Japan
    Exp Cell Res 317:2110-23. 2011
    ..Collectively, these results indicate that fad104 has an indispensable role in lung maturation, especially the maturation and differentiation of ATII cells...
  26. pmc Thymosin beta 4 is dispensable for murine cardiac development and function
    Indroneal Banerjee
    Department of Medicine, University of California San Diego, La Jolla, 92093, USA
    Circ Res 110:456-64. 2012
    ..To completely ablate Tβ4 and to rule out the possibility of off-target effects associated with shRNA gene silencing, further studies of global or cardiac-specific knockouts are critical...
  27. pmc Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice
    Monique Y Rennie
    Mouse Imaging Centre, Toronto Centre for Phenogenomics, Hospital for Sick Children, Canada
    Am J Physiol Heart Circ Physiol 302:H1261-73. 2012
    ..In both strains, enlargement of the fetoplacental arterial tree occurred primarily by increased arterial diameters with no change in segment numbers in late gestation...
  28. ncbi Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, KU Leuven, B 3000, Leuven, Belgium
    Mech Dev 111:61-73. 2002
    ....
  29. pmc Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
    Zhonghao Liu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:859-69. 2002
    ..These data demonstrate that FGF18 signals through another FGFR to regulate osteoblast growth. Signaling to multiple FGFRs positions FGF18 to coordinate chondrogenesis in the growth plate with osteogenesis in cortical and trabecular bone...
  30. pmc Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis
    Imke Albrecht
    Department of Biomedicine, Institute of Biochemistry and Genetics, University of Basel, Basel, Switzerland
    PLoS ONE 5:e14109. 2010
    ..Herein, we investigate the function of VEGF-B by the generation of mouse models of cancer with transgenic expression of VEGF-B or homozygous deletion of Vegfb.
  31. pmc The endothelium-dependent effect of RTEF-1 in pressure overload cardiac hypertrophy: role of VEGF-B
    Ming Xu
    Department of Physiology, Fourth Military Medical University, Xi an, China
    Cardiovasc Res 90:325-34. 2011
    ..However, the function of RTEF-1 in the communication between these two adjacent cell types has not been elucidated...
  32. pmc Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons
    Joke Dhondt
    Vesalius Research Center, Katholieke Universiteit Leuven, Leuven, Belgium
    FASEB J 25:1461-73. 2011
    ..Overall, this indicates that VEGF-B, instead of acting as an angiogenic factor, exerts direct neuroprotective effects through FLT1. These findings also suggest a clinically relevant role for VEGF-B in preventing distal neuropathies...
  33. pmc Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway
    Katarzyna Furrer
    Department of Surgery, Laboratory of the Swiss Hepato Pancreato Biliary and Transplantation Center, University of Zurich, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:2945-50. 2011
    ..DOI breaks this restraint through an endothelium-dependent mechanism driven by VEGF. This pathway highlights a target for reversing the age-associated decline in the capacity of the liver to regenerate...
  34. pmc Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac
    Jessica N Copeland
    Department of Pathology and Laboratory Medicine and Institute for Reproductive Health and Regenerative Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
    BMC Dev Biol 11:12. 2011
    ..To further understand the role of Notch signaling during endothelial differentiation and the genes regulated by this pathway, both loss-of-function and gain-of-function approaches were analyzed in vivo...
  35. pmc Transcription factor CHF1/Hey2 regulates coronary vascular maturation
    Tokumitsu Watanabe
    Division of Cardiology, University of Washington School of Medicine, Seattle, WA 98109, USA
    Mech Dev 127:418-27. 2010
    ..These findings suggest that CHF1/Hey2 regulates the later steps of coronary vascular development in both a myocardial-dependent, non-cell autonomous fashion and likely a vascular cell-specific effect as well...
  36. ncbi Novel cell lines promote the discovery of genes involved in early heart development
    E W Brunskill
    Division of Developmental Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3300, USA
    Dev Biol 235:507-20. 2001
    ..The results show that the 1H and ECL-2 cell lines can be used to discover novel genes expressed in the early cardiomyocyte...
  37. ncbi Angiogenesis and prostate cancer: identification of a molecular progression switch
    W J Huss
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 61:2736-43. 2001
    ....
  38. ncbi Transgenic mouse models in angiogenesis and cardiovascular disease
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, B 3000, Belgium
    J Pathol 190:387-405. 2000
    ..A selected number of molecules that have been studied in the authors' laboratory will be reviewed in more detail...
  39. ncbi Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis
    H Yonekura
    Department of Biochemistry, Kanazawa University School of Medicine, Kanazawa 920 8640, Japan
    J Biol Chem 274:35172-8. 1999
    ..Furthermore, antisense inhibition of PlGF protein production lowered the endothelial cell synthesis of DNA under hypoxic conditions. The results suggest that these VEGF family members may also take active parts in angiogenesis...
  40. ncbi Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Belgium
    Nat Med 5:495-502. 1999
  41. ncbi A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouse
    J Lagercrantz
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Biochim Biophys Acta 1398:157-63. 1998
    ..There are at present at least three specific effectors of vascular proliferation with clear differences in their expression...
  42. ncbi Analysis of the promoter region of the human VEGF-related factor gene
    G Silins
    Queensland Cancer Fund Research Unit, Joint Experimental Oncology Program, Queensland Institute of Medical Research, Herston, Australia
    Biochem Biophys Res Commun 230:413-8. 1997
    We have characterised the promoters of the human and murine VRF (vascular endothelial growth factor (VEGF) related factor) gene...
  43. ncbi Characterization of the murine VEGF-related factor gene
    S Townson
    Queensland Cancer Fund Research Unit, Join Experimental Oncology Program, Queensland Institute of Medical Research, Herston, Australia
    Biochem Biophys Res Commun 220:922-8. 1996
    ..cloning and characterization of the murine homolog of the human vascular endothelial growth factor-related factor (VRF) gene...
  44. ncbi Expression of the VEGF-related factor gene in pre- and postnatal mouse
    J Lagercrantz
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Biochem Biophys Res Commun 220:147-52. 1996
    ..The human VEGF related factor (VRF) gene was initially isolated using an 11q13 specific cosmid probe (D11S750)...
  45. ncbi Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b
    Yan Qiu
    Microvascular Research Laboratories, School of Veterinary Sciences, University of Bristol, Bristol, UK
    FASEB J 22:1104-12. 2008
    ..This study provides the first evidence for the role of endogenous antiangiogenic VEGF isoforms in normal physiology--their down-regulation is required for effective milk production...
  46. ncbi Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis
    Arne W Mould
    QCF Transgenic Laboratory, The Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Arthritis Rheum 48:2660-9. 2003
    To determine the role of vascular endothelial growth factor B (VEGF-B) in 2 mouse models of arthritis, antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA).
  47. ncbi Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice
    Yunjuan Sun
    Buck Institute for Age Research, Novato, California 94945, USA
    J Cereb Blood Flow Metab 24:1146-52. 2004
    Vascular endothelial growth factor-B (VegfB) is an angiogenic protein related to VegfA, although it acts on a different set of tyrosine kinase receptors. Like VegfA, VegfB is expressed in the brain and is induced at sites of brain injury...
  48. pmc Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos
    Sachie Hiratsuka
    Department of Genetics, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Cell Biol 25:355-63. 2005
    ....
  49. ncbi Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro
    Arne W Mould
    Queensland Institute of Medical Research, Brisbane, Australia
    Circ Res 97:e60-70. 2005
    ....
  50. ncbi Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice
    Ajay K Malik
    Department of Pathology, Genentech, South San Francisco, CA 94080, USA
    Blood 107:550-7. 2006
    ..The absence of compensatory VEGFR-1 signaling by VEGF-B and PlGF may have important implications for the development of anticancer strategies targeting the VEGF ligand/receptor system...
  51. ncbi Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration
    Yunjuan Sun
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Dev Biol 289:329-35. 2006
    Vascular endothelial growth factor-B (VEGFB) is an angiogenic and neuroprotective protein that reduces hypoxic and ischemic neuronal injury...
  52. pmc Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development
    Kory J Lavine
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 20:1651-66. 2006
    ..Consistent with this, activation of HH signaling in the adult heart leads to an increase in coronary vessel density...
  53. ncbi Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs
    Minke van Tuyl
    Canadian Institutes of Health Research Group in Lung Development, Hospital for Sick Children Research Institute, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 303:514-26. 2007
    ..Stimulation of vascularization with angiogenic factors such as Fgf2 and Ang1 partially restored tubular growth and branching in Shh-deficient lungs, suggesting that vascularization is required for branching morphogenesis...
  54. ncbi Vascular endothelial growth factor-B promotes in vivo angiogenesis
    Jean Sebastien Silvestre
    INSERM U54, Hopital Lariboisiere, 41 Bd de la Chapelle, 75475 Paris Cedex 10, France
    Circ Res 93:114-23. 2003
    ..This study demonstrates for the first time that VEGF-B, in part through its receptor VEGF-R1, promotes angiogenesis in association with an activation of Akt and eNOS-related pathways...
  55. ncbi Role of VEGF-B in the lung during development of chronic hypoxic pulmonary hypertension
    Vanessa Louzier
    Departement de Physiologie, Institut National de la Santé et de La Recherche Médicale Unité 492, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, 94010 Creteil, France
    Am J Physiol Lung Cell Mol Physiol 284:L926-37. 2003
    ..However, when overexpressed in the lung, VEGF-B can be as potent as VEGF-A in attenuating pulmonary hypertension, although it has no effect on eNOS expression or vascular permeability...
  56. doi Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180
    Xuling Huang
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Richard Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    Dev Biol 319:258-66. 2008
    ..Together, these data reveal for the first time that BAF180 is critical for coronary vessel formation...
  57. ncbi Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension
    Janet C Wanstall
    School of Biomedical Sciences, Department of Physiology and Pharmacology, University of Queensland, St Lucia, QLD 4072, Brisbane, Australia
    Cardiovasc Res 55:361-8. 2002
    ..To test the hypothesis that Vegf-B contributes to the pulmonary vascular remodelling, and the associated pulmonary hypertension, induced by exposure of mice to chronic hypoxia...
  58. pmc Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 135:3161-71. 2008
    ..Finally, we present evidence suggesting that coronary arteries and veins may be derived from distinct lineages...
  59. pmc Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production
    Olga Gealekman
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Am J Physiol Endocrinol Metab 295:E1056-64. 2008
    ..Expression of VEGFA and VEGFB, as well as of the angiopoietin-like factor-4 (ANGPTL4), was stimulated by in vivo treatment with RSG...
  60. pmc VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
    Fan Zhang
    National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:6152-7. 2009
    ..Our work thus indicates that the function of VEGF-B in the vascular system is to act as a "survival," rather than an "angiogenic" factor and that VEGF-B inhibition may offer new therapeutic opportunities to treat neovascular diseases...
  61. ncbi [Effect of VEGF-B on neuroprotection in mouse retinal ganglion cells]
    Shui Hu Zhang
    Department of Ophthalmology, The Second Hospital of Harbin Medical University, Harbin 150086, China
    Zhonghua Yan Ke Za Zhi 45:38-42. 2009
    ..To investigate the expression of vascular endothelial growth factor-B (VEGF-B) in retina and its effect on neuroprotection in mouse retinal ganglion cells (RGCs)...
  62. pmc Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
    Ming Hu
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Proc Natl Acad Sci U S A 107:2956-61. 2010
    ..Taken together, these results indicate that Hypb is required for embryonic vascular remodeling and provide a tool to study the function of H3K36 methylation in vasculogenesis/angiogenesis...
  63. ncbi Assignment of the mouse Vegfb gene to mouse chromosome 19 B by in situ hybridization
    L Gerace
    Sequence Detection System, Sample Preparation and Genetic Analysis Core Lab, Applera Italia, Monza, Milan, Italy
    Cytogenet Cell Genet 95:242-3. 2001
  64. ncbi Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells
    B P Zambrowicz
    Lexicon Genetics, The Woodlands, Texas 77381, USA
    Nature 392:608-11. 1998
    ..To facilitate the study of gene function on a large scale, we are using these techniques to create a library of ES cells called Omnibank, from which sequence-tagged mutations in 2,000 genes are described...

Research Grants1

  1. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
    ..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..