Vcam1

Summary

Gene Symbol: Vcam1
Description: vascular cell adhesion molecule 1
Alias: CD106, Vcam-1, vascular cell adhesion protein 1, V-CAM 1
Species: mouse

Top Publications

  1. doi Toxoplasma gondii: the severity of toxoplasmic encephalitis in C57BL/6 mice is associated with increased ALCAM and VCAM-1 expression in the central nervous system and higher blood-brain barrier permeability
    Neide Maria Silva
    Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG 38400 902, Brazil
    Exp Parasitol 126:167-77. 2010
  2. pmc Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice
    Daniel Teupser
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:123-8. 2006
  3. ncbi Vascular cell adhesion molecule-1 (VCAM-1) expression in murine lupus nephritis
    R P Wuthrich
    Department of Medicine, University of Alabama, Birmingham
    Kidney Int 42:903-14. 1992
  4. pmc A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture
    K Miyake
    Oklahoma Medical Research Foundation, Oklahoma City 73104
    J Cell Biol 114:557-65. 1991
  5. ncbi Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    L Osborn
    Biogen, Inc, Cambridge Center, Massachusetts 02142
    Cell 59:1203-11. 1989
  6. pmc Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    B J Steffen
    Department of Pathology, Stanford University School of Medicine, California
    Am J Pathol 145:189-201. 1994
  7. ncbi Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation
    G C Gurtner
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 9:1-14. 1995
  8. ncbi Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice
    L Kwee
    Department of Biotechnology, Roche Research Center, Hoffmann La Roche Inc, Nutley, NJ 07110 1199, USA
    Development 121:489-503. 1995
  9. ncbi Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development
    J T Yang
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 121:549-60. 1995
  10. ncbi Adhesion receptors on bone marrow stromal cells: in vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and gamma-irradiated mice
    K Jacobsen
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    Blood 87:73-82. 1996

Research Grants

  1. CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINS
    Eugene Butcher; Fiscal Year: 2001
  2. VASCULAR-MONOCYTE ADHESION MOLECULE IN ATHEROGENESIS
    Eugene Butcher; Fiscal Year: 2002
  3. LASER SCANNING CONFOCAL MICROSCOPE
    Robert Lechleider; Fiscal Year: 2003
  4. REGULATION OF EMBRYONIC ANGIOGENESIS BY SMAD PROTEINS
    Robert Lechleider; Fiscal Year: 2003
  5. Histone Methyltransferases and TGF-beta Signaling
    Robert Lechleider; Fiscal Year: 2004
  6. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
  7. Conference on Leukocyte Trafficking
    Eugene Butcher; Fiscal Year: 2004
  8. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
  9. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
  10. ENDOTHELIAL CELL BIOLOGY IN INFLAMMATION
    Eugene Butcher; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. doi Toxoplasma gondii: the severity of toxoplasmic encephalitis in C57BL/6 mice is associated with increased ALCAM and VCAM-1 expression in the central nervous system and higher blood-brain barrier permeability
    Neide Maria Silva
    Laboratory of Immunopathology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG 38400 902, Brazil
    Exp Parasitol 126:167-77. 2010
    ....
  2. pmc Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice
    Daniel Teupser
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:123-8. 2006
    ..Awareness of these complexities may have major consequences for the identification of atherosclerosis susceptibility genes by quantitative trait locus mapping...
  3. ncbi Vascular cell adhesion molecule-1 (VCAM-1) expression in murine lupus nephritis
    R P Wuthrich
    Department of Medicine, University of Alabama, Birmingham
    Kidney Int 42:903-14. 1992
    ..Thus, VCAM-1 and ICAM-1 function as renal parenchymal adhesion molecules and mediate the adherence of pathogenic inflammatory cells in murine lupus nephritis...
  4. pmc A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture
    K Miyake
    Oklahoma Medical Research Foundation, Oklahoma City 73104
    J Cell Biol 114:557-65. 1991
    ..The VCAM-like cell adhesion molecule on stromal cells and VLA-4 on lymphocyte precursors may both be important for B lymphocyte formation...
  5. ncbi Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    L Osborn
    Biogen, Inc, Cambridge Center, Massachusetts 02142
    Cell 59:1203-11. 1989
    ..VCAM-1, which belongs to the immunoglobulin gene super-family, may be central to recruitment of mononuclear leukocytes into inflammatory sites in vivo...
  6. pmc Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    B J Steffen
    Department of Pathology, Stanford University School of Medicine, California
    Am J Pathol 145:189-201. 1994
    ..These results are consistent with an important role for the vascular adhesion molecules VCAM-1 and ICAM-1 and for their lymphocytes receptors in lymphocyte recruitment to the central nervous system...
  7. ncbi Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation
    G C Gurtner
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 9:1-14. 1995
    ..The murine VCAM1 gene was disrupted by targeted homologous recombination, and a distinct phenotype was found in VCAM-1-deficient ..
  8. ncbi Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice
    L Kwee
    Department of Biotechnology, Roche Research Center, Hoffmann La Roche Inc, Nutley, NJ 07110 1199, USA
    Development 121:489-503. 1995
    ..These data suggest important roles for VCAM-1 and alpha 4 in the development of the placenta and the heart...
  9. ncbi Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development
    J T Yang
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 121:549-60. 1995
    ..These results raise the possibility of abortifacients targeting alpha 4 integrins, and raise serious questions about potential side effects of drugs currently being designed to block alpha 4 integrin functions in inflammation...
  10. ncbi Adhesion receptors on bone marrow stromal cells: in vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and gamma-irradiated mice
    K Jacobsen
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    Blood 87:73-82. 1996
    ....
  11. ncbi Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1
    J E Chin
    Cell Biology and Inflammation Research and Drug Development Toxicology, Pharmacia and Upjohn, Kalamazoo, Michigan 49001, USA
    Am J Physiol 272:L219-29. 1997
    ..The data suggest that these adhesion molecules may be suitable targets for therapeutic intervention in certain conditions of pulmonary inflammation...
  12. ncbi Cre-mediated generation of a VCAM-1 null allele in transgenic mice
    R W Terry
    Department of Inflammation and Autoimmune Diseases, Roche Research Center, Hoffmann LaRoche, Inc, Nutley, NJ 07110 1199, USA
    Transgenic Res 6:349-56. 1997
    ..The data also suggest a novel simplified strategy for using the Cre/loxP system in vivo, in which a single ES cell and line of mice can be used to create mice carrying either a null or conditional null allele...
  13. ncbi Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage
    S Adachi
    Molecular Genetics, Faculty of Medicine, Kyoto University, Japan
    Int Immunol 10:1-6. 1998
    ..The same defect was found in the jak3-/- mouse. In addition to the appearance of VCAM1+ spots, the clustering of IL-7Ralpha+ cells was absent in the jak3-/- mouse, though IL-7Ralpha+ cells are found to ..
  14. ncbi Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development
    P J Hunter
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Departments of Obstetrics and Gynaecology, and Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    Development 126:1247-58. 1999
    ..The specificity of the developmental defect in Mrj mutants suggests that each of these genes may have unique tissue and cellular activities...
  15. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
    ..Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells...
  16. ncbi IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches
    H Yoshida
    Department of Molecular Genetics, Faculty of Medicine, Institute of Genetics, Faculty of Medicine, Kyoto University, Syogoin Kawaharacho 53, Sakyoku, Kyoto 606 850, Japan
    Int Immunol 11:643-55. 1999
    ..Intestinal IL-7Ralpha+ cells are lymphoid in morphology but CD3(-) and functional in both nu/nu and Rag2-/- mice. These results implicate IL-7Ralpha+ CD3(-) cells as the direct inducer of the organizing center of PP...
  17. pmc Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow
    P A Koni
    Molecular Immunology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15 St, Room CA2007, Augusta, GA 30912, USA
    J Exp Med 193:741-54. 2001
    ..Thus, we report an until now unappreciated dominant role for VCAM-1 in lymphocyte homing to BM...
  18. pmc Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response
    C E Leuker
    Institute for Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    J Exp Med 193:755-68. 2001
    ..In addition, the humoral immune response to a T cell-dependent antigen is impaired. VCAM-1 serves an important role for B cell localization and the T cell-dependent humoral immune response...
  19. pmc A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
    M I Cybulsky
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto General Research Institute, Toronto, Ontario, Canada
    J Clin Invest 107:1255-62. 2001
    ..To evaluate functions of VCAM-1 in chronic disease, we disrupted its fourth Ig domain, producing the murine Vcam1(D4D) allele...
  20. ncbi Wnt7b regulates placental development in mice
    B A Parr
    MCD Biology, University of Colorado, 347 UCB, Boulder, Colorado 80309 0347, USA
    Dev Biol 237:324-32. 2001
    ..Wnt7b also is required for normal organization of cells in the chorionic plate. Thus, Wnt7b signaling is central to the early stages of placental development in mammals...
  21. ncbi Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage
    H M Dansky
    Rockefeller University, New York, NY, and the Toronto General Research Institute M I C, University of Toronto, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 21:1662-7. 2001
    Vascular cell adhesion molecule-1 (VCAM-1/Vcam1) is a cytokine-inducible member of the immunoglobulin gene superfamily that is expressed by arterial endothelial cells in regions predisposed to atherosclerosis and at borders of ..
  22. ncbi TNF-alpha-dependent ICAM-1- and VCAM-1-mediated inflammatory responses are delayed in neonatal mice infected with Pneumocystis carinii
    Mahboob H Qureshi
    Department of Microbiology, University of Kentucky, Veterans Administration Medical Center, Lexington, KY 40536, USA
    J Immunol 171:4700-7. 2003
    ..Additionally, neonatal T cells are defective in the ability to migrate across endothelial cells...
  23. pmc Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity
    Joan M Cook-Mills
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Biochem J 378:539-47. 2004
    ..Thus VCAM-1 stimulates the mobilization of intracellular and extracellular calcium and Rac1 activity that are required for the activation of NADPH oxidase...
  24. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
  25. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
    ..In summary, this is the first report of a mechanism for ROS function in VCAM-1 activation of endothelial cell MMPs during VCAM-1-dependent lymphocyte migration...
  26. ncbi Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility
    Jing Tian
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    Biochem Biophys Res Commun 329:1102-7. 2005
    ..apoE(-/-) mice...
  27. ncbi R-spondin3 is required for mouse placental development
    Motoko Aoki
    Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, Japan
    Dev Biol 301:218-26. 2007
    ..These findings suggest a critical role for Rspo3 in the interaction between chorion and allantois in labyrinthine development...
  28. pmc VCAM-1 signals activate endothelial cell protein kinase Calpha via oxidation
    Hiam Abdala-Valencia
    Allergy Immunology Division, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 177:6379-87. 2006
    ..This oxidation was blocked by inhibition of NADPH oxidase. In summary, VCAM-1 activation of endothelial cell NADPH oxidase induces transient PKCalpha activation that is necessary for VCAM-1-dependent transendothelial cell migration...
  29. pmc VCAM-1 activation of endothelial cell protein tyrosine phosphatase 1B
    Tracy L Deem
    Allergy Immunology Division, Northwestern University, Feinberg School of Medicine, 240 East Huron, Chicago, IL 60611, USA
    J Immunol 178:3865-73. 2007
    ..This PTP1B activity is necessary for VCAM-1-dependent transendothelial lymphocyte migration. These data show, for the first time, a function for PTP1B in VCAM-1-dependent lymphocyte migration...
  30. ncbi Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells
    Dominik Meier
    Division of Developmental Immunology, Center for Biomedicine, Department of Clinical and Biological Sciences DKBW, University of Basel, CH 4058 Basel, Switzerland
    Immunity 26:643-54. 2007
    ..Therefore, by controlling LTi cell numbers, IL-7 can regulate the formation of both normal and ectopic lymphoid organs...
  31. doi Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner
    Mark F R Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Leukoc Biol 84:152-61. 2008
    ..The postnatal development of the splenic white pulp, involving the influx of T cells, depends on LTalpha1beta2 expressed by B cells...
  32. pmc LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen
    Mark F Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 182:5439-45. 2009
    ..Furthermore, the same signals may regulate lymphangiogenesis to the lymph node through induction of VEGF-C...
  33. pmc Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo
    Anwarul Ferdous
    Department of Internal Medicine, Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Proc Natl Acad Sci U S A 108:16307-12. 2011
    ..5. Quantitative RT-PCR analysis of genes involved in placental development revealed significant attenuation of VCAM1 expression in FoxO1-null embryos...
  34. ncbi Structure of the murine VCAM1 gene
    M I Cybulsky
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Genomics 18:387-91. 1993
    The architecture of the murine VCAM1 gene, encoding vascular cell adhesion molecule-1, was determined. its 10 exons span approximately 20 kb...
  35. ncbi Murine VCAM-1. Molecular cloning, mapping, and analysis of a truncated form
    A G Kumar
    Department of Internal Medicine, Baylor College of Medicine, Houston, TX 77030
    J Immunol 153:4088-98. 1994
    ..We have cloned and characterized the murine Vcam1 gene including 3 kb of 5'-flanking sequences and mapped the gene to chromosome 3 near Amy1...
  36. ncbi Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers
    P G Schlegel
    Bone Marrow Transplant Program H1353, Stanford University School of Medicine, CA 94305, USA
    J Immunol 155:3856-65. 1995
    ..Long-term engraftment of allogeneic bone marrow was documented in all transplanted mice by PCR analysis of a microsatellite region in the IL-1 beta gene...
  37. ncbi Cloning and sequencing of mouse VCAM-1 cDNA
    M Araki
    Department of Pathology, C M U, University of Geneva, Switzerland
    Gene 126:261-4. 1993
    ..Unlike other adhesion molecules, the cytoplasmic tails (19 aa) of mouse and human VCAM-1 are identical, despite a 85.2% similarity only at the nt level, suggesting a critical functional role...
  38. pmc Cytokine induction of an alternatively spliced murine vascular cell adhesion molecule (VCAM) mRNA encoding a glycosylphosphatidylinositol-anchored VCAM protein
    R W Terry
    Molecular Sciences Group, Hoffmann La Roche Inc, Nutley, NJ 07110 1199
    Proc Natl Acad Sci U S A 90:5919-23. 1993
    ..These data demonstrate that alternate forms of VCAM are produced under different physiological conditions and suggest that VCAMGPI may have a distinct role in inflammatory processes...
  39. pmc The heat-stable antigen can alter very late antigen 4-mediated adhesion
    M Hahne
    Hans Spemann Laboratory, Max Planck Institute for Immunobiology, Freiburg, Germany
    J Exp Med 179:1391-5. 1994
    ..Thus, expression of HSA on pre-B cells modifies the binding specificity of VLA-4 for two known ligands...
  40. ncbi Methylxanthines and calcium-mobilizing agents inhibit the expression of cytokine-inducible nitric oxide synthase and vascular cell adhesion molecule-1 in murine microvascular endothelial cells
    M Bereta
    Department of Pathology, Hahnemann University, Philadelphia, Pennsylvania 19102
    Exp Cell Res 212:230-42. 1994
    ..In addition, our results suggest that NO produced by iNOS acts as a metabolic switch during inflammation by inhibiting oxidative phosphorylation and forcing vascular endothelial cells to temporarily utilize anaerobic energy metabolism...
  41. ncbi Expanding roles for alpha 4 integrin and its ligands in development
    A M Sheppard
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110
    Cell Adhes Commun 2:27-43. 1994
    ..Finally, based on their patterns of expression, we conclude that VCAM-1 only participates in a subset of interactions involving alpha 4 integrins, whereas FN appears to be the more general ligand...
  42. ncbi Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin
    S Aigner
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg, Germany
    Int Immunol 7:1557-65. 1995
    ..Our data suggest that HSA, in addition to the recently identified 160 kDa glycoprotein ligand on mouse neutrophils, belongs to a group of monospecific P-selectin ligands on myeloid cells...
  43. pmc Genetic analysis of alpha 4 integrin functions in the development of mouse skeletal muscle
    J T Yang
    Howard Hughes Medical Institute Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 135:829-35. 1996
    ..Taking these results together, we conclude that alpha 4 integrins appear not to play essential roles in normal skeletal muscle development...
  44. pmc Failure to induce anti-glomerular basement membrane glomerulonephritis in TNF alpha/beta deficient mice
    B Ryffel
    Department of Immunology, University of Cape Town, South Africa
    Int J Exp Pathol 79:453-60. 1998
    ..Therefore, we conclude that TNF plays a key role for the recruitment of inflammatory cells by preventing the upregulation of endothelial adhesion molecule and the subsequent development of proliferative glomerulonephritis...
  45. ncbi Attenuation of leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine endotoxemia
    D Nolte
    Department of Oral and Maxillofacial Surgery Regional Plastic Surgery, Knappschaftskrankenhaus Bochum Langendreer, University of Bochum, Bochum, Germany
    Eur Surg Res 36:331-7. 2004
    ..This in vivo study investigates the biological role of murine PECAM-1 and VCAM-1 for leukocyte sequestration into the lung, liver and striated skin muscle...
  46. pmc Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells
    Lois L Cavanagh
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1029-37. 2005
    ..Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell-mediated recall responses in the bone marrow...
  47. pmc Sustained alterations in biodistribution of stem/progenitor cells in Tie2Cre+ alpha4(f/f) mice are hematopoietic cell autonomous
    Gregory V Priestley
    Division of Hematology, Department of Medicine, Box 357710, Seattle, WA 98195, USA
    Blood 109:109-11. 2007
    ....
  48. ncbi High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A
    Dachun Yao
    Juvenile Diabetes Research Foundation International Center for Diabetic Complications Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 282:31038-45. 2007
    ..This novel mechanism for regulating gene expression may play a role in the pathobiology of diabetic vascular disease...
  49. doi Stress increases VCAM-1 expression at the fetomaternal interface in an abortion-prone mouse model
    M B Prados
    GlycoImmunoBiology Laboratory, Instituto de Investigaciones Cardiológicas Prof Dr Alberto C Taquini ININCA, CONICET Universidad de Buenos Aires, Marcelo T de Alvear 2270 2, Ciudad Autónoma de Buenos Aires C1122AAJ, Argentina
    J Reprod Immunol 89:207-11. 2011
    ..In the high fetal loss model, however, the frequency of VCAM-1+ vessels was dramatically increased. This study shows that VCAM-1 expression is modulated by stress at the fetomaternal interface in abortion-prone cross-breeding...
  50. ncbi [Effects of high and low shear stress on vascular remodeling and endothelial vascular cell adhesion molecular-1 expression in mouse abdominal aorta]
    Jian Liu
    Department of Cardiology, Southern Medical University, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1349-52. 2011
    ..To establish a mouse model of abdominal aorta stenosis and analyze the alterations in the arterial wall response to high and low shear stress...
  51. doi Systemic inflammation, cellular influx and up-regulation of ovarian VCAM-1 expression in a mouse model of polycystic ovary syndrome (PCOS)
    Maria Emilia Solano
    Laboratory for Experimental Feto Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Reprod Immunol 92:33-44. 2011
    ..These findings offer novel therapeutic opportunities for PCOS, such as blockage of VCAM-1 expression...
  52. doi Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice
    Takahiro Hara
    Laboratory of Biological Protection, Department of Biological Responses, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    J Immunol 189:1577-84. 2012
    ..Overall, IL-7-GFP knock-in mice serve as a unique and powerful tool to examine the identity and distribution of IL-7-expressing cells in vivo...
  53. pmc The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis
    Zhiying Zou
    Department of Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 121:3228-36. 2013
    ..Our findings reveal that CCBE1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that EBI formation is regulated differently in the fetal liver and bone marrow...
  54. pmc Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling
    Tony DeFalco
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Biol Reprod 88:91. 2013
    ....
  55. doi Hydrophobic interaction mediating self-assembled nanoparticles of succinobucol suppress lung metastasis of breast cancer by inhibition of VCAM-1 expression
    Haiqiang Cao
    State Key Laboratory of Drug Research and Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China
    J Control Release 205:162-71. 2015
    ..Thereby, SN could evoke a new effective therapeutic efficacy of SCB on lung metastasis of breast cancer by inhibition of VCAM-1 expression. ..
  56. doi Neutrophils rapidly transit inflamed lymphatic vessel endothelium via integrin-dependent proteolysis and lipoxin-induced junctional retraction
    David A Rigby
    University of Oxford, Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, and Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Headington, Oxford, United Kingdom
    J Leukoc Biol 98:897-912. 2015
    ..These findings reveal an unexpectedly intimate collaboration between neutrophils and the lymphatic vessel endothelium, in which these phagocytic leukocytes act as pathfinders for their own transit during inflammation. ..
  57. pmc VCAM-1-targeted magnetic resonance imaging reveals subclinical disease in a mouse model of multiple sclerosis
    Sébastien Serres
    Cancer Research UK Medical Research Council Gray Institute for Radiation Oncology and Biology, Department of Oncology, Churchill Hospital, Oxford, OX3 7LJ, UK
    FASEB J 25:4415-22. 2011
    ..These findings describe a highly sensitive molecular imaging tool that may enable detection of currently invisible pathology in MS, thus accelerating diagnosis, guiding treatment, and enabling quantitative disease assessment...
  58. pmc The role of ROS in ionizing radiation-induced VLA-4 mediated adhesion of RAW264.7 cells to VCAM-1 under flow conditions
    Ye Yuan
    Edison Biotechnology Institute and Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio, USA
    Radiat Res 179:62-8. 2013
    ....
  59. ncbi Phosphatidylinositol glycan (PI-G) anchored membrane proteins. Amino acid requirements adjacent to the site of cleavage and PI-G attachment in the COOH-terminal signal peptide
    L D Gerber
    Department of Neurosciences, Roche Institute of Molecular Biology, Nutley, New Jersey 07110
    J Biol Chem 267:12168-73. 1992
    ..Thus, just as there is a -1, -3 rule for predicting cleavage by NH2-terminal signal peptidase, there appears to be a comparable omega, omega + 2 rule for predicting cleavage/PI-G addition by COOH-terminal signal transamidase...
  60. ncbi Cloning of an inflammation-specific phosphatidyl inositol-linked form of murine vascular cell adhesion molecule-1
    P Moy
    Biogen, Incorporated, Cambridge, Massachusetts 02142
    J Biol Chem 268:8835-41. 1993
    Vascular cell adhesion molecule-1 (VCAM1) is a member of the immunoglobulin (Ig) superfamily which interacts with the integrin very late antigen-4 (VLA4)...
  61. ncbi CD106 (VCAM-1) in testicular immunoregulation
    S Sainio-Pöllänen
    Department of Anatomy, University of Turku, Finland
    J Reprod Immunol 33:221-38. 1997
    The expression of CD18, CD49d/CD29, CD44, CD54 and CD106 was studied in the testis of normal mice at various ages, in the cryptorchid testis, in the testis of estrogen-treated mice and in the testis of non-obese diabetic (NOD) mice, ..
  62. ncbi Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes
    Z Cui
    Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan
    Exp Anim 47:83-8. 1998
    ..In addition, four conserved regions were newly revealed. The method described in this study appears to be simple and efficient for constructing a whole genome comparative map of the rat and mouse...
  63. ncbi The value of gene 'knock-out' for assessing the role of cell adhesion molecules in renal disease
    A McGinty
    Department of Medicine and Therapeutics, Mater Misericordiae Hospital, University College Dublin, Ireland
    Nephrol Dial Transplant 14:27-9. 1999
  64. ncbi Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice
    C L Ramos
    Departments of Biomedical Engineering and Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, VA, USA
    Circ Res 84:1237-44. 1999
    ....
  65. ncbi Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse
    Takeshi Fujiwara
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Ave South, Nashville, TN 37232 2175, USA
    Development 129:4685-96. 2002
    ....
  66. ncbi Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models
    Kimihiko Nakatani
    Department of Pathology and Department of Internal Medicine, Ehime University School of Medicine, Onsen gun, Ehime, Japan
    Kidney Int 65:1290-300. 2004
    ..To clarify whether vascular endothelial adhesion molecules in glomeruli might contribute to the severity and diversity of glomerular lesions in lupus nephritis, their expression in lupus models was analyzed...
  67. ncbi Increased expression of adhesion molecules in uremic atherosclerosis in apolipoprotein-E-deficient mice
    Susanne Bro
    Department of Nephrology P 2131, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Am Soc Nephrol 15:1495-503. 2004
    ....
  68. pmc Up-regulation of endothelial nitric oxide synthase inhibits pulmonary leukocyte migration following lung ischemia-reperfusion in mice
    Alexander Kaminski
    Department of Cardiac Surgery, University of Rostock, Rostock, Germany
    Am J Pathol 164:2241-9. 2004
    ..We conclude that eNOS attenuates post-ischemic inflammatory injury to the lung most probably via inhibition of endothelial adhesion molecule expression...
  69. ncbi STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004
    ....
  70. ncbi Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development
    Ji One Kang
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, IGM240, 2250 Alcazar St, Los Angeles, CA 90033, USA
    Mech Dev 122:57-65. 2005
    ..We therefore conclude that epicardial and endocardial signals converge on common proliferative components, but diverge in downstream pathways that lead to compact vs. trabecular morphogenic differentiation...
  71. ncbi Mechanisms of hypotonicity-induced calcium signaling and integrin activation by arachidonic acid-derived inflammatory mediators in B cells
    Peimin Zhu
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:4981-9. 2005
    ....
  72. ncbi Vimentin function in lymphocyte adhesion and transcellular migration
    Mikko Nieminen
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, P O Box 123, FIN 20521 Turku, Finland
    Nat Cell Biol 8:156-62. 2006
    ..These data show that intermediate filaments are active in lymphocyte adhesion and transmigration...
  73. ncbi VCAM-1 expression on dystrophic muscle vessels has a critical role in the recruitment of human blood-derived CD133+ stem cells after intra-arterial transplantation
    Manuela Gavina
    Stem Cell Laboratory, Department of Neurological Sciences, IRCCS, Centro Dino Ferrari, University of Milan, Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    Blood 108:2857-66. 2006
    ....
  74. ncbi Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation
    Toru Sato
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Japan
    Gene 379:166-74. 2006
    ..We suggest that PcG complexes may act to mediate certain inductive signals maybe through IL-7Ralpha to allow sufficient proliferation of lymphoid inducer cells during PP organogenesis...
  75. pmc Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis
    Jenny Jongstra-Bilen
    Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 203:2073-83. 2006
    ..Intimal CD68+ leukocytes were reduced in VCAM-1-deficient mice, suggesting that mechanisms of leukocyte accumulation in the intima of normal aorta are analogous to those in atherosclerosis...
  76. ncbi Importance of IFN-gamma-mediated expression of endothelial VCAM-1 on recruitment of CD8+ T cells into the brain during chronic infection with Toxoplasma gondii
    Xisheng Wang
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Interferon Cytokine Res 27:329-38. 2007
    ..gondii infection, although LFA-1/ICAM-1 interaction may also be involved in this process...
  77. pmc Transcriptional repressor erf determines extraembryonic ectoderm differentiation
    Chara Papadaki
    Medical School, University of Crete, Voutes, Heraklion, Crete 710 03, Greece
    Mol Cell Biol 27:5201-13. 2007
    ..Our data suggest that attenuation of FGF/Erk signaling and consecutive Erf nuclear localization and function is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment...
  78. ncbi The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium
    Matthew D Silverman
    University of Michigan Health System, Internal Medicine Department, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 56:1817-26. 2007
    ..This study was undertaken to investigate the hypothesis that EPCs selectively home to inflamed joint tissue and may perpetuate synovial neovascularization...
  79. pmc Association of a Vcam1 mutation with atherosclerosis susceptibility in diet-induced models of atherosclerosis
    Toru Miyoshi
    Department of Radiology, Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Atherosclerosis 196:234-9. 2008
    ..polymorphism (SNP) between C57BL/6J (B6) and C3H/HeJ (C3H) mouse strains at position 2077 in the coding region of Vcam1 that leads to substitution of an amino acid from aspartic acid (D) to asparagine (N) in the protein product...
  80. ncbi Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1
    Beat A Kaufmann
    Cardiovascular Division, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA
    Circulation 116:276-84. 2007
    ..We hypothesized that molecular imaging of vascular cell adhesion molecule-1 (VCAM-1) expression with contrast-enhanced ultrasound (CEU) could be used for this purpose...
  81. pmc siRNA silencing reveals role of vascular cell adhesion molecule-1 in vascular smooth muscle cell migration
    Erik J Petersen
    Department of Radiology, University of Virginia, Charlottesville, VA 22908, USA
    Atherosclerosis 198:301-6. 2008
    ..Thus, our findings indicate that VCAM-1 is necessary for the migration of smooth muscle cells and interfering VCAM-1 expression could be an effective approach to prevention and treatment of atherosclerosis and restenosis...
  82. doi Enhanced expression of vascular cell adhesion molecule-1 by corticotrophin-releasing hormone contributes to progression of atherosclerosis in LDL receptor-deficient mice
    Yuqing Wu
    Department of Pharmacology, Nanjing Medical University, PR China
    Atherosclerosis 203:360-70. 2009
    ..This study provides a new insight into the effect of CRH on atherosclerosis and suggests a potential target for the prevention and treatment of atherosclerosis...
  83. doi Gene expression of LOX-1, VCAM-1, and ICAM-1 in pre-atherosclerotic mice
    Anne Mette Fisker Hag
    Cluster for Molecular Imaging, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3b, BMI 12 3 15, DK 2200 Copenhagen N, Denmark
    Biochem Biophys Res Commun 377:689-93. 2008
    ..It therefore seems likely that these circulating markers are not suited to detect early atherosclerosis...
  84. pmc VCAM-1 blockade delays disease onset, reduces disease severity and inflammatory cells in an atopic dermatitis model
    Lin Chen
    Department of Dermatology, University of Illinois, Chicago, IL 60612, USA
    Immunol Cell Biol 88:334-42. 2010
    ..VCAM-1 is more critical in developing skin inflammation in this model...
  85. pmc Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    Guangwen Ren
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, USA
    J Immunol 184:2321-8. 2010
    ..Taken together, these findings reveal a novel function of adhesion molecules in immunoregulation by MSCs and provide new insights for the clinical studies of antiadhesion therapies in various immune disorders...
  86. doi Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase
    Rogier M Reijmers
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 184:3656-64. 2010
    ....
  87. doi Developmental changes of cell adhesion molecule expression in the fetal mouse liver
    Yoshinori Sugiyama
    Department of Biology, Faculty of Science, Shizuoka University, Shizuoka City, Japan
    Anat Rec (Hoboken) 293:1698-710. 2010
    ..These results suggest that each cell adhesion molecule may play an important role during development in hepatic histogenesis, including hepatoblast/hepatocyte-stellate cell interactions, hemopoiesis, and bile duct morphogenesis...
  88. pmc Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatment
    Jihang Ju
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 285:41152-60. 2010
    ..Together, these results elucidate a novel mechanism for the involvement of DNA-PK in the positive regulation of p50 NF-κB to drive VCAM-1 expression...
  89. pmc Temporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis
    Sebastian Doerck
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 5:e15478. 2010
    ..Therefore it is likely to assume that intervention at the blood brain barrier is time dependent and could result in different therapeutic outcomes depending on the phase of CNS lesion development...
  90. pmc Genome-wide approaches reveal functional interleukin-4-inducible STAT6 binding to the vascular cell adhesion molecule 1 promoter
    Hideto Tozawa
    Research Center for Advanced Science and Technology, University of Tokyo, 4 6 1 Komaba, Meguro, Tokyo 153 8904, Japan
    Mol Cell Biol 31:2196-209. 2011
    ..Identification of a novel IL-4-mediated VCAM-1 enhancer may provide a foundation for targeted therapy in vascular disease...
  91. pmc Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
    Karen M Osorio
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 193:235-50. 2011
    ..Thus, a master regulator of hematopoiesis also controls HFSC emergence and maintenance via modulation of bidirectional cross talking between nascent stem cells and their niche...
  92. pmc Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells
    Masahiro Koide
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto 602 8566, Japan
    Proc Natl Acad Sci U S A 108:9472-7. 2011
    ..These functions of ARIA might offer a unique therapeutic potential...
  93. ncbi Cloning of an alternate form of vascular cell adhesion molecule-1 (VCAM1)
    C Hession
    Biogen, Inc, Cambridge, Massachusetts 02142
    J Biol Chem 266:6682-5. 1991
    Vascular cell adhesion molecule-1 (VCAM1) of the Ig superfamily is induced by the inflammatory cytokines interleukin-1 and tumor necrosis factor on human umbilical vein endothelial cells (HUVECs)...
  94. pmc Structural requirements for adhesion of soluble recombinant murine vascular cell adhesion molecule-1 to alpha 4 beta 1
    M E Renz
    Department of Immunology, Genentech, Inc, South San Francisco, California 94080
    J Cell Biol 125:1395-406. 1994
    ..Although these residues, identified as crucial for cell adhesion, are all located in domain 1, it is evident that there is a structural requirement for domains 1 and 2 to be intact so that cell adhesive function can occur...
  95. ncbi Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells
    T Kinashi
    Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115
    J Leukoc Biol 57:168-73. 1995
    Monoclonal antibodies to murine vascular cell adhesion molecule-1 (VCAM-1, CD106) revealed not only the expected VCAM-1 molecule with an apparent molecular weight of 100 kDa, but also a molecule with a smaller size of 46 kDa in stromal ..
  96. ncbi Expression of functional ICAM-1 and VCAM-1 adhesion molecules by an immortalized epithelial cell clone derived from the small intestine
    X C Li
    Department of Surgery, University of Western Ontario, Canada
    Cell Immunol 175:58-66. 1997
    ..These findings suggest that small bowel-derived epithelial cells may be capable of expressing a defined set of functional adhesion molecules during mucosal inflammation...
  97. ncbi Expression of laminin alpha1, alpha2, alpha4, and alpha5 chains, fibronectin, and tenascin-C in skeletal muscle of dystrophic 129ReJ dy/dy mice
    B Ringelmann
    Institute for Experimental Medicine, University of Erlangen Nürnburg, Schwabachanlage 10, Erlangen, Germany
    Exp Cell Res 246:165-82. 1999
    ..These results have significant ramifications in the diagnosis of human merosin-negative CMD...
  98. ncbi Pulmonary irradiation-induced expression of VCAM-I and ICAM-I is decreased by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Center Institute, Pennsylvania 15213, USA
    Biol Blood Marrow Transplant 8:175-87. 2002
    ....
  99. pmc Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment
    Jennifer K Sengbusch
    Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 157:873-82. 2002
    ..T., H. Rayburn, and R.O. Hynes. 1995. Development. 121:549-560)...
  100. ncbi Regulation of cellular adhesion molecule expression in murine oocytes, peri-implantation and post-implantation embryos
    David P Lu
    Department of Pathology, University of Sydney, NSW 2006, Australia
    Cell Res 12:373-83. 2002
    ....
  101. ncbi Vascular cell adhesion molecule-1 expression and hematopoietic supportive capacity of immortalized murine stromal cell lines derived from fetal liver and adult bone marrow
    Joyce M Koenig
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    In Vitro Cell Dev Biol Anim 38:538-43. 2002
    ..Our studies suggest that cellular interactions other than those mediated by VCAM-1 are involved in the increased adhesive capacity of immortalized murine stroma derived from fetal liver...

Research Grants14

  1. CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINS
    Eugene Butcher; Fiscal Year: 2001
    ..These studies should define signaling mechanisms regulating the adhesion of leukocytes and other cells, and may lead to novel therapeutic approaches for the control of neoplastic and inflammatory diseases ..
  2. VASCULAR-MONOCYTE ADHESION MOLECULE IN ATHEROGENESIS
    Eugene Butcher; Fiscal Year: 2002
    ..The proposed studies will elucidate the structure of this novel vascular receptor and its role in monocyte recruitment in atherogenesis. They may lead to new approaches to the regulation of the atherogenic process. ..
  3. LASER SCANNING CONFOCAL MICROSCOPE
    Robert Lechleider; Fiscal Year: 2003
    ..Successful funding of this application will fill a clear need for expansion of confocal microscopy facilities on the GUMC campus and will allow for an increase in the quality and quantity of results derived from NIH funded research. ..
  4. REGULATION OF EMBRYONIC ANGIOGENESIS BY SMAD PROTEINS
    Robert Lechleider; Fiscal Year: 2003
    ..We will use a combination of genetic, cell biological and biochemical techniques to define the signaling pathways that are mediated by Smad1 and Smad5 during embryonic angiogenesis. ..
  5. Histone Methyltransferases and TGF-beta Signaling
    Robert Lechleider; Fiscal Year: 2004
    ..These studies will provide the foundation into further analysis of the mechanism of Suv-Smad interaction in transcriptional silencing. ..
  6. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
    ..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
  7. Conference on Leukocyte Trafficking
    Eugene Butcher; Fiscal Year: 2004
    ..abstract_text> ..
  8. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  9. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
    ..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
  10. ENDOTHELIAL CELL BIOLOGY IN INFLAMMATION
    Eugene Butcher; Fiscal Year: 2008
    ..The proposed studies should expand our understanding of the critical role of the vascular endothelium in regulating lymphocyte trafficking during normal and pathologic immune responses. ..
  11. Novel Dendritic Cell Chemoattractant and Receptor
    Eugene Butcher; Fiscal Year: 2009
    ..abstract_text> ..
  12. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  13. Intestinal Lymphocyte Trafficking
    Eugene Butcher; Fiscal Year: 2009
    ....
  14. Tolerogenic DC as Therapeutic Agents in GVHD
    Eugene C Butcher; Fiscal Year: 2010
    ..Together, these studies will define in detail the potential of CCR9+ pDCs to suppress deleterious effects of GVHD in settings modeling situations in which human patients encounter pathogenic GVHD responses. ..