Vash1

Summary

Gene Symbol: Vash1
Description: vasohibin 1
Alias: AI834978, D930046M13Rik, G630009D10Rik, vasohibin-1
Species: mouse

Top Publications

  1. pmc Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis
    Kazuhide Watanabe
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Clin Invest 114:898-907. 2004
  2. pmc Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    PLoS ONE 7:e46459. 2012
  3. ncbi Vasohibin prevents arterial neointimal formation through angiogenesis inhibition
    Hiroshi Yamashita
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 345:919-25. 2006
  4. doi Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis
    Daisuke Saito
    Dept of Medicine and Clinical Science, Okayama Univ Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 300:F873-86. 2011
  5. pmc Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis
    Takahiro Heishi
    Department of Vascular Biology, Institute of Development, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 176:1950-8. 2010
  6. pmc Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    Tomoko Hosaka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Pathol 175:430-9. 2009
  7. ncbi Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
    Jikui Shen
    The Departments of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, Maryland 21287 9277, USA
    FASEB J 20:723-5. 2006
  8. doi Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis
    Hiroshi Kimura
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Blood 113:4810-8. 2009
  9. ncbi Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
    Takumi Shibuya
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 26:1051-7. 2006
  10. doi Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation
    Xue Bai
    Department of Physiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 30:2467-74. 2010

Scientific Experts

  • Johann Kern
  • Yasufumi Sato
  • Yasuhiro Suzuki
  • Hiroki Miyashita
  • Hikaru Sonoda
  • Hideki Ohta
  • Kazuhide Watanabe
  • Soichi Ito
  • Daisuke Saito
  • Miho Kobayashi
  • Hiroshi Yamashita
  • Takahiro Heishi
  • Tomoko Hosaka
  • Hiroshi Kimura
  • Megumu Saito
  • Takuya Moriya
  • Yutaka Furutani
  • Kaori Suenaga
  • Norikazu Hinamoto
  • Mayumi Abe
  • Kazue Shimizu
  • Yohei Maeshima
  • Hirofumi Makino
  • Tatsuyo Nasu
  • Hitoshi Sugiyama
  • Katsuyuki Tanabe
  • Hiroko Yamasaki
  • Takashi Kondo
  • Xue Bai
  • Susumu Satomi
  • Hisamichi Naito
  • Tooru Shimosegawa
  • Kanji Hojo
  • Jikui Shen
  • Takumi Shibuya
  • Seiji Yano
  • Takuro Miyazaki
  • Yumi Shiozaki-Sato
  • Soichi Kojima
  • Mitsuko Hara
  • Nobuo Yaegashi
  • Junichi Sugawara
  • Shuji Kitahara
  • Kana Masuda
  • Yuka Arata
  • Hiroyuki Watatani
  • Haruyo Ujike
  • Sachiko Horie
  • Yasushi Hoshikawa
  • Yoshinori Okada
  • Takanobu Nakamura
  • Hideki Hayashi
  • Manabu Ono
  • Tatsuaki Watanabe
  • Takashi Takahashi
  • Takumi Nakamura
  • Yuichi Mitsuda
  • Lingfang Zeng
  • Justin C Mason
  • Xian Wang
  • Aleksandar Ivetic
  • Andriana Margariti
  • Mitsunobu Matsumoto
  • Shingo Arioka
  • Yanhua Hu
  • Ouassila Habi
  • Tomoaki Takakura
  • Chihiro Yamauchi
  • Qingbo Xu
  • Yuichi Oike
  • Satoshi Suzuki
  • Takashi Fujiwara
  • Hiroyasu Kidoya
  • Nobuyuki Takakura
  • Akira Sato
  • Xiaoru Yang
  • Wei Hong Xiao
  • Koichi Tabayashi
  • Peter A Campochiaro
  • Sean F Hackett
  • Keiichi Imagawa
  • Yasuhiro Hasegawa
  • Yuanying Ding
  • Hideo Maki

Detail Information

Publications17

  1. pmc Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis
    Kazuhide Watanabe
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Clin Invest 114:898-907. 2004
    ..We propose vasohibin to be an endothelium-derived negative feedback regulator of angiogenesis...
  2. pmc Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    PLoS ONE 7:e46459. 2012
    Vasohibin-1 (VASH1) is isolated as an endothelial cell (EC)-produced angiogenesis inhibitor...
  3. ncbi Vasohibin prevents arterial neointimal formation through angiogenesis inhibition
    Hiroshi Yamashita
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 345:919-25. 2006
    ..Vasohibin exhibited no direct effect on migration and proliferation of smooth muscle cells. Thus, vasohibin has an activity to prevent neointimal formation by inhibiting adventitial angiogenesis...
  4. doi Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis
    Daisuke Saito
    Dept of Medicine and Clinical Science, Okayama Univ Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 300:F873-86. 2011
    ....
  5. pmc Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis
    Takahiro Heishi
    Department of Vascular Biology, Institute of Development, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 176:1950-8. 2010
    ..These results suggest vasohibin1 to be the first known intrinsic factor having broad-spectrum antilymphangiogenic activity and indicate that it suppresses lymph node metastasis...
  6. pmc Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    Tomoko Hosaka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Pathol 175:430-9. 2009
    ....
  7. ncbi Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
    Jikui Shen
    The Departments of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, Maryland 21287 9277, USA
    FASEB J 20:723-5. 2006
    ..These data support the hypothesis that vasohibin acts as a negative feedback regulator of neovascularization in the retina and suggest that suppression of VEGF receptor 2 may play some role in mediating its activity...
  8. doi Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis
    Hiroshi Kimura
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Blood 113:4810-8. 2009
    ..These results indicate that vasohibin-1 is expressed in ECs in the termination zone to halt angiogenesis, whereas vasohibin-2 is expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis...
  9. ncbi Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
    Takumi Shibuya
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 26:1051-7. 2006
    ..We recently isolated vasohibin, a novel vascular endothelial growth factor (VEGF)-inducible endothelium-derived angiogenesis inhibitor. Our aim is to find DNA sequences homologous to vasohibin and determine their expression profile...
  10. doi Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation
    Xue Bai
    Department of Physiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 30:2467-74. 2010
    ..To use protein kinase C (PKC) δ-knockout mice to investigate the role of PKCδ in lesion development and to understand the underlying mechanism of the vascular disease...
  11. pmc Enhanced cancer metastasis in mice deficient in vasohibin-1 gene
    Soichi Ito
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan Department of Advanced Surgical Science and Technology, Tohoku University School of Medicine, Sendai, Japan
    PLoS ONE 8:e73931. 2013
    Vasohibin-1 (VASH1) is isolated as an endogenous angiogenesis inhibitor produced by the vascular endothelium. We previously reported that tumor growth and tumor angiogenesis were augmented in VASH1 (-/-) mice...
  12. pmc Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation
    Kaori Suenaga
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Aoba ku, Sendai, Miyagi, Japan Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Aoba ku, Sendai, Miyagi, Japan
    PLoS ONE 9:e104728. 2014
    Vasohibin-1 (VASH1) and vasohibin-2 (VASH2), the 2 members of the vasohibin family, have been identified as novel regulators of angiogenesis. VASH1 ceases angiogenesis, whereas VASH2 stimulates sprouting...
  13. pmc Exacerbation of diabetic renal alterations in mice lacking vasohibin-1
    Norikazu Hinamoto
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    PLoS ONE 9:e107934. 2014
    Vasohibin-1 (VASH1) is a unique endogenous inhibitor of angiogenesis that is induced in endothelial cells by pro-angiogenic factors...
  14. doi Hepatic fibrosis and angiogenesis after bile duct ligation are endogenously expressed vasohibin-1 independent
    Yutaka Furutani
    Micro signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies, Saitama, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 463:384-8. 2015
    ..There was unexpectedly no difference between these mice, suggesting that anti-fibrogenic and angiogenic activities of the endogenous vasohibin-1 might be masked in the normal liver at early stage of hepatic fibrosis in mice. ..
  15. ncbi Proteolytic inactivation of anti-angiogenic vasohibin-1 by cancer cells
    Megumu Saito
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biochem 160:227-232. 2016
    Vasohibin-1 (VASH1) is an angiogenesis inhibitor synthesized by endothelial cells (ECs) under conditions associated with physiological and pathological angiogenesis including cancers...
  16. pmc Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo
    Johann Kern
    Division of Internal Medicine V, Tumor Biology and Angiogenesis Laboratory, Medical University Innsbruck, Innrain 66, A 6020 Innsbruck, Austria
    BMC Cancer 9:284. 2009
    ..The murine homologue of human vasohibin (mVASH1), a putative antiangiogenic protein, was investigated for its effects on in vitro and in vivo angiogenesis...
  17. doi Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population
    Hisamichi Naito
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Biochem 145:653-9. 2009
    ..Recently, vasohibin-1 (VASH1), an endothelium-derived negative feedback regulator of angiogenesis, has been isolated and characterized...