Uncx

Summary

Gene Symbol: Uncx
Description: UNC homeobox
Alias: Chx4, Uncx4.1, homeobox protein unc-4 homolog, Unc4.1 homeobox, homeobox protein Uncx4.1
Species: mouse

Top Publications

  1. ncbi Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Development 130:4259-68. 2003
  2. pmc Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints
    Ingeborg Teppner
    GSF National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    BMC Dev Biol 7:68. 2007
  3. ncbi The role of presenilin 1 during somite segmentation
    K Koizumi
    Department of Molecular Embryology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Development 128:1391-402. 2001
  4. pmc Cloning and characterization of four murine homeobox genes
    A C Rovescalli
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 4036, USA
    Proc Natl Acad Sci U S A 93:10691-6. 1996
  5. ncbi Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system
    A Mansouri
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, Germany
    Dev Dyn 210:53-65. 1997
  6. ncbi Defects in somite formation in lunatic fringe-deficient mice
    N Zhang
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Nature 394:374-7. 1998
  7. ncbi lunatic fringe is an essential mediator of somite segmentation and patterning
    Y A Evrard
    Department of Biochemistry and Molecular Biology and Program in Genes and Development, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nature 394:377-81. 1998
  8. ncbi Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
    Y Xue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Hum Mol Genet 8:723-30. 1999
  9. ncbi Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
    I B Barrantes
    Amgen Institute, Ontario Cancer Institute, Departments of Medical Biophysics and Immunology University of Toronto 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 9:470-80. 1999
  10. ncbi Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes
    J L Moran
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Mamm Genome 10:535-41. 1999

Scientific Experts

  • Julien Vermot
  • Sally L Dunwoodie
  • Yasumasa Bessho
  • R F Bulleit
  • Ingeborg Teppner
  • Changhui Ge
  • Vitezslav Bryja
  • Karin Schuster-Gossler
  • David A Stafford
  • D B Donoviel
  • Yumiko Saga
  • Yu Takahashi
  • Terry P Yamaguchi
  • Achim Gossler
  • Mark Lewandoski
  • Ravindra B Chalamalasetty
  • Matthew J Anderson
  • Gregg Duester
  • Thomas J Cunningham
  • Katrin Serth
  • Yasutaka Niwa
  • Ryoichiro Kageyama
  • William C Dunty
  • Kristin K Biris
  • Jérome Chal
  • Alexander Aulehla
  • A Mansouri
  • Emily T Shifley
  • Olivier Pourquie
  • William Sewell
  • Lisa L Sandell
  • Lino Tessarollo
  • Ioan Ovidiu Sirbu
  • Laura S Gammill
  • Nitya Ramkumar
  • Natalia Molotkova
  • Jun Kanno
  • Mitsuru Morimoto
  • Dustin R Williams
  • Rieko Ajima
  • Tobias Bohnenpoll
  • Yukiko Harima
  • Natalia Soshnikova
  • Masayuki Oginuma
  • Sandeep Kumar
  • Luke T Krebs
  • Satoshi Kitajima
  • L A Naiche
  • Takashi Ando
  • Susan E Cole
  • Juan Galceran
  • Courtney M Karner
  • Toshinao Oyama
  • Muriel Rhinn
  • Ralf Cordes
  • Minsub Shim
  • Tohru Inoue
  • Emma R Andersson
  • Hai Song
  • Jun Takahashi
  • Neeraja Sammeta
  • Raquel Lourenço
  • Rowena Suriben
  • Susan Skuntz
  • Teddy Young
  • Michael Stauber
  • Christopher N Vlangos
  • Paul A Trainor
  • Julaine Roffers-Agarwal
  • Xianling Zhao
  • Hiroki Kokubo
  • Nobuo Sasaki
  • Andreas Kispert
  • Duncan B Sparrow
  • Shinichi Aizawa
  • Dorian M Gonzalez
  • Amit Kumar
  • Carl T Fulp
  • Alexander Alexandrovich
  • Juliane Feller
  • Yuji Mishina
  • Wataru Satoh
  • Mariko Hirano
  • Eric F Rappaport
  • Kenro Kusumi
  • Milena B Furtado
  • Kenji Imai
  • Kathleen M Loomes
  • Christine R Norton
  • Yojiro Yamanaka

Detail Information

Publications107 found, 100 shown here

  1. ncbi Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Development 130:4259-68. 2003
    ..We conclude from our analyses that Mesp2 functions as a central mediator of such Notch pathways and regulates the gene expression required for rostrocaudal patterning of somites...
  2. pmc Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints
    Ingeborg Teppner
    GSF National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    BMC Dev Biol 7:68. 2007
    ..We did this by overexpressing a functional copy of the Dll1 gene throughout the paraxial mesoderm, in particular in anterior somite compartments, during somitogenesis in transgenic mice...
  3. ncbi The role of presenilin 1 during somite segmentation
    K Koizumi
    Department of Molecular Embryology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Development 128:1391-402. 2001
    ..In summary, we propose that Ps1 is involved in the functional manifestation of the segmentation clock in the presomitic mesoderm...
  4. pmc Cloning and characterization of four murine homeobox genes
    A C Rovescalli
    Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 4036, USA
    Proc Natl Acad Sci U S A 93:10691-6. 1996
    Four novel murine homeobox genes, Uncx-4.1, OG-2, OG-9, and OG-12, were cloned and partially sequenced. The amino acid sequence of the mouse Uncx-4...
  5. ncbi Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system
    A Mansouri
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Gottingen, Germany
    Dev Dyn 210:53-65. 1997
    ..The temporal and spatial expression pattern suggests that Uncx4.1 may play an important role in kidney development and in the differentiation of the sclerotome and the nervous system...
  6. ncbi Defects in somite formation in lunatic fringe-deficient mice
    N Zhang
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Nature 394:374-7. 1998
    ..These results indicate that Lfng encodes an essential component of the Notch signalling pathway during somitogenesis in mice...
  7. ncbi lunatic fringe is an essential mediator of somite segmentation and patterning
    Y A Evrard
    Department of Biochemistry and Molecular Biology and Program in Genes and Development, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nature 394:377-81. 1998
    ....
  8. ncbi Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
    Y Xue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Hum Mol Genet 8:723-30. 1999
    ..These results establish the phenotype of Cm /+ mice as a contiguous gene deletion syndrome and demonstrate that Jag1 is essential for remodeling of the embryonic vasculature...
  9. ncbi Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
    I B Barrantes
    Amgen Institute, Ontario Cancer Institute, Departments of Medical Biophysics and Immunology University of Toronto 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 9:470-80. 1999
    ....
  10. ncbi Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes
    J L Moran
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Mamm Genome 10:535-41. 1999
    ..Comparative analysis of mammalian Fringe genomic organization suggests that the first exon is evolutionarily labile and that the Fringe genes have a genomic structure distinct from those of previously characterized glycosyltransferases...
  11. ncbi Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9
    A Mansouri
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 127:2251-8. 2000
    ..1 upstream of Pax9 in the caudolateral sclerotome. Our results further indicate that Uncx4.1 may be involved in the differential cell adhesion properties of the somite...
  12. pmc Dynamic expression and essential functions of Hes7 in somite segmentation
    Y Bessho
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 15:2642-7. 2001
    ..These results indicate that Hes7 controls the cyclic expression of lunatic fringe and is essential for coordinated somite segmentation...
  13. ncbi Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm
    Sally L Dunwoodie
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:1795-806. 2002
    ....
  14. ncbi Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice
    Nian Zhang
    Van Andel Research Institute, Grand Rapids, Michigan, USA
    Genesis 33:21-8. 2002
    ..These mice exhibit the skeletal defects normally observed in Lfng-deficient mice, but we detected no obvious synergistic or additive effects in the double mutant animals...
  15. ncbi Wnt3a plays a major role in the segmentation clock controlling somitogenesis
    Alexander Aulehla
    Abteilung Entwicklungsbiologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
    Dev Cell 4:395-406. 2003
    ..We propose that the segmentation clock is established by Wnt/beta-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates...
  16. pmc Transcriptional oscillation of lunatic fringe is essential for somitogenesis
    Katrin Serth
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    Genes Dev 17:912-25. 2003
    ....
  17. pmc Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
    Shaolin Shi
    Department of Cell Biology, Albert Einstein College Medicine, New York, NY 10461, USA
    Proc Natl Acad Sci U S A 100:5234-9. 2003
    ..Protein O-fucosyltransferase 1 is therefore an essential core member of Notch signaling pathways in mammals...
  18. pmc Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
    Yasumasa Bessho
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Dev 17:1451-6. 2003
    ..Thus, periodic repression by Hes7 protein is critical for the cyclic transcription of Hes7 and Lfng, and this negative feedback represents a molecular basis for the segmentation clock...
  19. ncbi Specification of vertebral identity is coupled to Notch signalling and the segmentation clock
    Ralf Cordes
    Institut für Molekularbiologie OE5250, Medizinische Hochschule, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Development 131:1221-33. 2004
    ..Together, these results provide genetic evidence that precisely regulated levels of Notch activity as well as cyclic Lfng activity are critical for positional specification of the anteroposterior body axis in the paraxial mesoderm...
  20. pmc The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments
    Markus Bussen
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Genes Dev 18:1209-21. 2004
    ..In summary, Tbx18 appears to act downstream of Mesp2 and Delta/Notch signaling to maintain the separation of anterior and posterior somite compartments...
  21. ncbi Instability of Hes7 protein is crucial for the somite segmentation clock
    Hiromi Hirata
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Genet 36:750-4. 2004
    ..We simulated this effect mathematically using a direct autorepression model. Thus, instability of Hes7 is essential for sustained oscillation and for its function as a segmentation clock...
  22. pmc LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis
    Juan Galceran
    Gene Center and Institute of Biochemistry, University of Munich, 81377 Munich, Germany
    Genes Dev 18:2718-23. 2004
    ..Finally, the induced expression of LEF1-beta-catenin activates the expression of endogenous Dll1 in fibroblastic cells. Thus, Wnt signaling can affect the Notch pathway by a LEF1-mediated regulation of Dll1...
  23. ncbi Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Science 308:563-6. 2005
    ..These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos...
  24. ncbi Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation
    Stacey S Huppert
    Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Cell 8:677-88. 2005
    ..These data clarify multiple roles for Notch signaling during segmentation and suggest that the earliest stages of somitogenesis are regulated by both Notch-dependent and Notch-independent functions of presenilin...
  25. ncbi Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning
    Kwang Won Seo
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 290:200-10. 2006
    ....
  26. ncbi Neurohypophysial dysmorphogenesis in mice lacking the homeobox gene Uncx4.1
    C H J Asbreuk
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    J Mol Endocrinol 36:65-71. 2006
    ..1 in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions...
  27. pmc Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm
    Ioan Ovidiu Sirbu
    OncoDevelopmental Biology Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 8:271-7. 2006
    ....
  28. ncbi Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation
    William C Dunty
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH, Frederick, MD 21702, USA
    Development 135:85-94. 2008
    ..Thus, Wnt3a regulates somitogenesis by activating a network of interacting target genes that promote mesodermal fates, activate the segmentation clock, and position boundary determination genes in the anterior PSM...
  29. ncbi A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation
    Alexander Aulehla
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Nat Cell Biol 10:186-93. 2008
    ..This gradient of nuclear beta-catenin defines the size of the oscillatory field and controls key aspects of PSM maturation and segment formation, emphasizing the central role of Wnt signalling in this process...
  30. doi Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton
    Emily T Shifley
    Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    Development 135:899-908. 2008
    ....
  31. pmc Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation
    Juliane Feller
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Hanover, Germany
    Genes Dev 22:2166-71. 2008
    ..Thus, segmentation and anterior-posterior somite patterning can be uncoupled, differential Notch signaling is not required to form segment borders, and Notch is unlikely to be the pacemaker of the segmentation clock...
  32. pmc Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis
    William Sewell
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Dev Biol 329:400-9. 2009
    ..Surprisingly, we only identified a small number of genes disrupted by the Dll3 mutation. These include Uncx, a somite gene required for rib and vertebral patterning, and Nrarp, a regulator of Notch/Wnt signaling in ..
  33. doi Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite
    Jun Takahashi
    Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Okazaki, Aichi, Japan
    Dev Biol 342:134-45. 2010
    ..We propose that the rostro-caudal pattern is established by dynamic interaction of Notch activity with two Mesp2 domains, which are defined in successive segmentation cycles by Notch, Tbx6 and Ripply1/2...
  34. pmc Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium
    Neeraja Sammeta
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    Mol Cell Neurosci 45:398-407. 2010
    b>Uncx (Phd1, Chx4) is a paired homeobox transcription factor gene...
  35. ncbi The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column
    M Leitges
    Abt Molekulare Embryologie and Abt Entwicklungsbiologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, Germany
    Development 127:2259-67. 2000
    ..The mesenchymal anlagen for these elements are formed initially, but condensation and chondrogenesis do not occur. Hence, Uncx4.1 is required for the maintenance and differentiation of particular elements of the axial skeleton...
  36. ncbi Mesp2 initiates somite segmentation through the Notch signalling pathway
    Y Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Nat Genet 25:390-6. 2000
    ..Therefore, Mesp2- and Ps1-dependent activation of Notch-signalling pathways might differentially regulate Dll1 expression, resulting in the establishment of the rostro-caudal polarity of somites...
  37. ncbi The Nrarp gene encodes an ankyrin-repeat protein that is transcriptionally regulated by the notch signaling pathway
    L T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    Dev Biol 238:110-9. 2001
    ..These observations demonstrate that the Nrarp gene is an evolutionarily conserved transcriptional target of the Notch signaling pathway...
  38. ncbi The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock
    Yasutaka Niwa
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Dev Cell 13:298-304. 2007
    ..We thus propose that Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling...
  39. pmc Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation
    Natalia Molotkova
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mech Dev 122:145-55. 2005
    ..An important concept to emerge from our studies is that the somitic mesodermal RA signal acts in the neuroectoderm but not mesoderm to generate a spinal cord fate...
  40. ncbi Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo
    Takashi Inoue
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Dev Biol 306:669-84. 2007
    ....
  41. pmc Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton
    Minsub Shim
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:16206-17. 2010
    ..Our results demonstrate that the aberrant COX-2 signaling during embryonic development is teratogenic and suggest a possible association of COX-2 with fetal malformations of unknown etiology...
  42. pmc Cooperative activity of noggin and gremlin 1 in axial skeleton development
    David A Stafford
    Department of Molecular and Cell Biology and Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA
    Development 138:1005-14. 2011
    ..We conclude that Nog and Grem1 cooperate to maintain a BMP signaling-free zone that is a crucial prerequisite for Hh-mediated sclerotome induction...
  43. pmc Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis
    Yasutaka Niwa
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto, Japan
    Genes Dev 25:1115-20. 2011
    ..These results suggest that Notch oscillators define the prospective somite region, while Fgf oscillators regulate the pace of segmentation...
  44. pmc The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program
    Ravindra B Chalamalasetty
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH, Frederick, Maryland 21702, USA
    Nat Commun 2:390. 2011
    ..Msgn1 also indirectly regulates cyclic genes in the Fgf and Wnt pathways. Thus, Msgn1 is a central component of a transcriptional cascade that translates a spatial Wnt3a gradient into a temporal pattern of clock gene expression...
  45. pmc The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice
    Luke T Krebs
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    Genesis 50:366-74. 2012
    ....
  46. doi Duplications of hox gene clusters and the emergence of vertebrates
    Natalia Soshnikova
    Department of Genetics and Evolution, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
    Dev Biol 378:194-9. 2013
    ....
  47. doi Posterior skeletal development and the segmentation clock period are sensitive to Lfng dosage during somitogenesis
    Dustin R Williams
    The Department of Molecular Genetics, The Ohio State University, 105 Biological Sciences Building, 484 West 12th Avenue, Columbus, OH 43210, USA
    Dev Biol 388:159-69. 2014
    ..Further, they suggest that modulation of the Notch signaling by Lfng affects the clock period during development. ..
  48. pmc Wnt8a and Wnt3a cooperate in the axial stem cell niche to promote mammalian body axis extension
    Thomas J Cunningham
    Development, Aging, and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, California
    Dev Dyn 244:797-807. 2015
    ..Body axis extension requires Wnt8a in lower vertebrates, but in mammals Wnt3a is required, although the anterior trunk develops in the absence of Wnt3a...
  49. pmc O-fucosylation of DLL3 is required for its function during somitogenesis
    Katrin Serth
    Institut für Molekularbiologie OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Germany
    PLoS ONE 10:e0123776. 2015
    ....
  50. doi Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy
    Jérome Chal
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS UMR 7104, INSERM U964, Universite de Strasbourg, Illkirch Graffenstaden, France
    Nat Biotechnol 33:962-9. 2015
    ..Fibers derived from ES cells of mdx mice exhibit an abnormal branched phenotype resembling that described in vivo, thus providing an attractive model to study the origin of the pathological defects associated with DMD. ..
  51. pmc Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2
    Nitya Ramkumar
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Program in Biochemistry and Structural Biology, Cell and Developmental Biology, and Molecular Biology, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, New York, United States of America
    PLoS Genet 11:e1005551. 2015
    ....
  52. doi Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development
    Matthew J Anderson
    Cancer and Developmental Biology Laboratory, National Cancer Institute, Frederick, 21702, Maryland
    Genesis 54:91-8. 2016
    ..This Fgf3(Δ)-Fgf4(flox)-cis line will be useful to study redundancy of these genes in a variety of tissues and stages in development...
  53. pmc An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension
    Matthew J Anderson
    Genetics of Vertebrate Development Section, Cancer and Developmental Biology Lab, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
    PLoS Genet 12:e1006018. 2016
    ..Uncovering this FGF3-BMP signaling axis is a major advance toward understanding how these tissue layers interact during axis extension with important implications in human disease. ..
  54. doi A new gain-of-function mouse line to study the role of Wnt3a in development and disease
    Ravindra B Chalamalasetty
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, NCI Frederick, NIH, Frederick, Maryland, 21702
    Genesis 54:497-502. 2016
    ..These data indicate that the exogenously expressed Wnt3a stimulates the Wnt/β-catenin signaling pathway, as expected. The Rosa26(Wnt3a) mouse line should prove to be an invaluable tool to study the function of Wnt3a in vivo. ..
  55. pmc Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning
    Hai Song
    Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Nature 466:378-82. 2010
    ..Our data suggest that PCP acts earlier than the unidirectional nodal flow during bilateral symmetry breaking in vertebrates and provide insight into the functional mechanism of PCP in organizing the vertebrate tissues in development...
  56. doi The floor plate is sufficient for development of the sclerotome and spine without the notochord
    Takashi Ando
    Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860 0811, Japan
    Mech Dev 128:129-40. 2011
    ....
  57. doi Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo
    Toshinao Oyama
    Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Development 138:5235-46. 2011
    ..These results indicate that engagement of Mam is essential for Notch signaling, and that the three Mam isoforms have distinct roles in vivo...
  58. doi Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene
    Yukiko Harima
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Cell Rep 3:1-7. 2013
    ..These results suggest that the number of introns is important for the appropriate tempo of oscillatory expression and that Hes7 is a key regulator of the pace of the segmentation clock...
  59. doi Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate
    Tobias Bohnenpoll
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Dev Biol 380:25-36. 2013
    ..Our study provides new insights into the molecular diversity of urogenital progenitor cells and helps to understand the specification of the ureteric mesenchymal sub-lineage...
  60. ncbi A novel gene selectively expressed in the cerebellum
    R F Bulleit
    Department of Pharmacology, University of Maryland School of Medicine, Baltimore 21201, USA
    Neurosci Lett 209:93-6. 1996
    ..An increase in its expression correlates with the timing of granule neuron differentiation in the cerebellum. Thus, the expression of Cer-1 may provide a selective marker for terminal differentiation of cerebellar granule neurons...
  61. ncbi Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1
    S S Huppert
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 405:966-70. 2000
    ..Our results show that efficient intramembranous processing of Notch1 is indispensable for embryonic viability and proper early embryonic development in vivo...
  62. ncbi The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele
    J Beckers
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mech Dev 95:35-46. 2000
    ..However, fine genetic mapping places rv into an interval on chromosome seven that does not contain a gene encoding a known component of the Notch signaling pathway...
  63. pmc The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis
    T Kume
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 15:2470-82. 2001
    ..We propose that the two genes interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop...
  64. ncbi Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites
    F R Schubert
    King s College London, MRC Centre for Developmental Neurobiology, New Hunt s House, London, United Kingdom
    Dev Dyn 222:506-21. 2001
    ..This finding suggests an early function of Pax3 during the formation of epithelial somites...
  65. ncbi Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis
    Aya Nomura-Kitabayashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyohga, Setagaya Ku, Tokyo 158 8501, Japan
    Development 129:2473-81. 2002
    ..These results suggest that the Mesp family of transcription factors is involved in both segment border formation and establishment of RC polarity through different genetic cascades...
  66. ncbi Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses
    Jun Deng
    Division of Oncology, Department of Medicine, Stanford University Medical Center, CA 94305, USA
    Int Immunol 14:513-23. 2002
    ..Taken together, these results indicate that CD81 expression by T cells greatly enhances cognate T-B cell interactions and greatly augments intracellular activation pathways leading to Th2 polarization...
  67. ncbi Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure
    Natasha S Hamblet
    Department of Pediatrics, UCSD Comprehensive Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0627, USA
    Development 129:5827-38. 2002
    ..Thus, Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure, and there is functional redundancy between Dvl1 and Dvl2 in some phenotypes...
  68. ncbi Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome
    Georg C Schwabe
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    Dev Dyn 229:400-10. 2004
    ..The Ror2(-/-) mouse provides a suitable model that may help to explain many of the underlying developmental malformations in individuals with Robinow syndrome...
  69. ncbi Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
    Chikara Kokubu
    Institute of Developmental Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Development 131:5469-80. 2004
    ..Together, we propose that Lrp6 is one of the key genetic components for the pathogenesis of vertebral segmentation defects and of osteoporosis in humans...
  70. ncbi Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2
    Yoshiro Nakajima
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 133:2517-25. 2006
    ..In addition, ectopic Mesp2 expression induces abnormally epithelialized structures, which support to the idea that Mesp2 induces the formation of segmental borders by activating genes that play roles in cellular epithelialization...
  71. ncbi Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Dev Biol 304:593-603. 2007
    ..The activation and subsequent suppression of Notch signaling might thus be a crucial event for both stripe pattern formation and boundary formation...
  72. ncbi TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton
    Ryoji Yao
    Department of Cell Biology, The JFCR Cancer Institute, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Cancer Sci 98:555-62. 2007
    ..Thus, in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals...
  73. doi A role for GATA-6 in vertebrate chondrogenesis
    Alexander Alexandrovich
    Division of Cardiovascular Medicine, King s College London, London SE5 9NU, UK
    Dev Biol 314:457-70. 2008
    ..These data therefore suggest that GATA-6 also plays a role in chondrogenesis and that Gpr49 is a potential direct target of GATA regulation in this process...
  74. pmc Identification of Arx transcriptional targets in the developing basal forebrain
    Carl T Fulp
    Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 17:3740-60. 2008
    ....
  75. pmc BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4
    Milena B Furtado
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia
    Genes Dev 22:3037-49. 2008
    ..We conclude that BMP/SMAD1 signaling sets a bilateral, repressive threshold for NODAL-dependent Nodal activation in LPM, limiting availability of SMAD4. This repressive threshold is essential for bistable output of the LR system...
  76. pmc Neuropilin receptors guide distinct phases of sensory and motor neuronal segmentation
    Julaine Roffers-Agarwal
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Development 136:1879-88. 2009
    ..These data show that Nrp2 and Nrp1 work together to produce segmentation of sensory and motor nerves, and that dorsal peripheral nervous system metamerism is generated in a stepwise, Nrp-dependent process...
  77. pmc Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning
    Xianling Zhao
    Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 19:1050-7. 2009
    ....
  78. pmc Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton
    Susan Skuntz
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3706, USA
    Dev Biol 332:383-95. 2009
    ..and they are associated with alterations in the expression of at least three transcription factor genes, Tbx18, Uncx, and Bapx1...
  79. pmc Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis
    Christopher N Vlangos
    Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 334:418-28. 2009
    ..These findings demonstrate that caudal dysgenesis in acd embryos is secondary to p53-dependent apoptosis. Importantly, this study reinforces a significant link between genomic instability and birth defects...
  80. pmc Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis
    Michael Stauber
    Developmental Genetics Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 4:e7996. 2009
    ..We present evidence that Lfng controls dorsal-ventral axis specification in the tail, and also suggest that Lfng controls the expression or activity of a long-range signal that regulates axial extension...
  81. pmc Left-right function of dmrt2 genes is not conserved between zebrafish and mouse
    Raquel Lourenço
    Faculdade de Medicina da Universidade de Lisboa, Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Lisboa, Portugal
    PLoS ONE 5:e14438. 2010
    ..However, nothing was known about its role during left-right patterning in the lateral plate mesoderm or in the symmetric synchronization of somite formation...
  82. pmc Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development
    Courtney M Karner
    Department of Internal Medicine Nephrology and Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Dallas, TX 75390, USA
    Development 138:1247-57. 2011
    ..These findings provide novel insights into the molecular mechanisms that regulate progenitor cell differentiation during normal and pathological conditions...
  83. pmc Rdh10 mutants deficient in limb field retinoic acid signaling exhibit normal limb patterning but display interdigital webbing
    Thomas J Cunningham
    Sanford Burnham Medical Research Institute, Development and Aging Program, La Jolla, California, CA, USA
    Dev Dyn 240:1142-50. 2011
    ..These findings demonstrate that RA is unnecessary for limb patterning but required later for interdigital tissue loss...
  84. pmc FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis
    L A Naiche
    Genetics of Vertebrate Development Section, National Cancer Institute, Frederick, MD 21701, USA
    Proc Natl Acad Sci U S A 108:4018-23. 2011
    ..Furthermore, these data show that FGF action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM progenitor tissue...
  85. pmc Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment
    Muriel Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch F 67404, France
    Proc Natl Acad Sci U S A 108:16687-92. 2011
    ..These results underscore the importance of maternal retinoids in preventing congenital birth defects, and lead to a revised model of the importance of RDH10 and RALDHs in controlling embryonic RA distribution...
  86. ncbi Impaired intervertebral disc formation in the absence of Jun
    Axel Behrens
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 130:103-9. 2003
    ..Subsequently, fusion of vertebral bodies caused a scoliosis of the axial skeleton. Thus, Jun is required for axial skeletogenesis by regulating notochord survival and intervertebral disc formation...
  87. ncbi The protocadherin papc is involved in the organization of the epithelium along the segmental border during mouse somitogenesis
    Jerry Rhee
    Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
    Dev Biol 254:248-61. 2003
    ..Together, these data indicate that papc is an important regulator of somite epithelialization associated with segmentation...
  88. ncbi Defective somite patterning in mouse embryos with reduced levels of Tbx6
    Phillip H White
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Development 130:1681-90. 2003
    ..The similarity in the phenotypes we describe here and that of some human birth defects, such as spondylocostal dysostosis, raises the possibility that mutations in Tbx6 or components of this pathway may be responsible for these defects...
  89. ncbi Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells
    Masato S Ota
    Embryology Unit, Children s Medical Research Institute, Westmead, NSW Australia
    Dev Dyn 230:216-28. 2004
    ....
  90. ncbi Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagayaku, Tokyo 158 8501, Japan
    Development 132:787-96. 2005
    ....
  91. ncbi Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr (jumbled spine and ribs) mouse
    Shinya Okano
    Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido University, Kita ku, Sapporo, 060 0818
    Jpn J Vet Res 52:145-9. 2005
    ..These results indicate that the Jsr mutation disrupts the A-P polarity of somites during the somitogenesis without altering Lfng expression pattern in the PSM...
  92. ncbi Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling
    Laura S Gammill
    Division of Biology 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Development 133:99-106. 2006
    ..Interestingly, neural crest cells still condense into segmentally arranged dorsal root ganglia in Npn2 nulls, suggesting that segmental neural crest migration and segmentation of the peripheral nervous system are separable processes...
  93. ncbi Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis
    Jacqueline Kim Dale
    Howard Hughes Medical Institute, Stowers Institute for Medical Research, 1000 East 50 th Street, Kansas City, Missouri 64110, USA
    Dev Cell 10:355-66. 2006
    ..Thus, Snail genes define a class of cyclic genes that coordinate segmentation and PSM morphogenesis...
  94. ncbi BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, MD C4 10, C458, Research Triangle Park, NC 27709, USA
    Development 133:3767-75. 2006
    ..This suggests that BMP and FGF signaling function antagonistically during paraxial mesoderm development...
  95. ncbi Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
    Mitsuru Morimoto
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Dev Biol 300:687-98. 2006
    ..Moreover, we have found that somitogenesis in the early stages is more susceptible to changes in the Mesp gene dosage, indicating that a threshold level of Mesp activity must be required for the progression of normal somitogenesis...
  96. ncbi Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation
    Yu Takahashi
    Cellular and Molecular Toxicology Division, National Institute of Health Sciences, Setagayaku, Tokyo, Japan
    Dev Dyn 236:1484-94. 2007
    ..The present data strongly suggest that patterning events by bHLH-type transcription factors have deep impacts on regional chondrogenic and myogenic differentiation of somitic cells, mainly by means of control of Pax genes...
  97. ncbi Dll3 and Notch1 genetic interactions model axial segmental and craniofacial malformations of human birth defects
    Kathleen M Loomes
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Dev Dyn 236:2943-51. 2007
    ..Thus, Dll3-Notch1 double heterozygous mice model human congenital scoliosis and craniofacial disorders...
  98. ncbi Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis
    Kristin K Biris
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, NCI Frederick, NIH, Frederick, Maryland 21702, USA
    Dev Dyn 236:3167-72. 2007
    ..Our data are consistent with Ripply2 functioning as a segment boundary determination gene during mammalian embryogenesis. Developmental..
  99. pmc Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects
    Amit Kumar
    Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    Dev Dyn 237:3591-601. 2008
    ..No other abnormalities were found, suggesting that Nodal signaling has no additional essential functions in developmental patterning within the extensive mesodermal and endodermal domains marked by T-Cre activity...
  100. pmc Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak
    Rowena Suriben
    Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA
    Nat Genet 41:977-85. 2009
    ..We conclude that Dact1 contributes to morphogenesis at the primitive streak by regulating Vangl2 upstream of cell adhesion and the PCP pathway...