Genomes and Genes
Gene Symbol: Umod
Alias: THP, Urehd1, urehr4, uromodulin, Tamm-Horsfall urinary glycoprotein, uromucoid
- Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null miceAndrew P Evan
Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5055S, Indianapolis, IN 46223, USA
Urol Res 38:439-52. 2010..Two animal models--the NHERF-1 and THP-null mice--have been shown to develop sites of interstitial apatite plaque in the renal papilla...
- Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturationH T Yuan
Nephrourology Unit, Institute of Child Health, University College London, Medical School, United Kingdom
J Am Soc Nephrol 10:1722-36. 1999..These data are consistent with the hypothesis that Tie-2 has roles in maturation of both glomeruli and vasa rectae...
- Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injuryM Tanaka
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Kidney Int 73:181-91. 2008..Our study suggests that USAG-1 expression in a kidney biopsy could be useful in predicting outcome...
- Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant miceElisabeth Kemter
Chair for Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU, Munich, Munich, Germany
PLoS ONE 8:e78337. 2013b>Uromodulin-associated kidney disease (UAKD) summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD) mutation involved...
- Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trapYan Liu
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 287:16365-78. 2012..Here we show that elimination of Tamm-Horsfall protein (THP) expression from mouse kidneys caused a marked elevation of circulating IFN-γ, IL1α, TNF-α, IL6, CXCL1, and IL13...
- Urinary secretion and extracellular aggregation of mutant uromodulin isoformsCéline Schaeffer
Dulbecco Telethon Institute, San Raffaele Scientific Institute, Milan, Italy
Kidney Int 81:769-78. 2012b>Uromodulin is exclusively expressed in the thick ascending limb and is the most abundant protein secreted in urine where it is found in high-molecular-weight polymers...
- Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in miceSebastian Bachmann
Medical Faculty of the Charite, Department of Anatomy, Franz Volhard Clinic, HELIOS Clinics and Max Delbrück Center for Molecular Medicine, Berlin, Germany
Am J Physiol Renal Physiol 288:F559-67. 2005The Tamm-Horsfall protein (THP; uromodulin), the dominant protein in normal urine, is produced exclusively in the thick ascending limb of Henle's loop...
- Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formationLan Mo
Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10010, USA
Kidney Int 66:1159-66. 2004..Here we examined the role of Tamm-Horsfall protein (THP), the principal urinary protein, in urinary defense against renal calcium crystal formation, using a THP knockout ..
- Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease modelsBernhard Aigner
Institute of Molecular Animal Breeding and BiotechnologyInstitute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
Am J Physiol Renal Physiol 292:F1560-7. 2007....
- Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communicationJames M Bates
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Kidney Int 65:791-7. 2004..Factors involved in clearing bacteria from the urinary tract are poorly understood. Tamm-Horsfall protein (THP), the most abundant protein in mammalian urine, has been postulated to play a role in defense against urinary tract ..
- Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive mannerKerim Mutig
Department of Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
J Biol Chem 286:30200-10. 2011..Co-expressed Tamm-Horsfall protein (THP) has been proposed to interact with NKCC2. We hypothesized that THP modulates NKCC2 activity in TAL...
- Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expressionMatteo Trudu
Dulbecco Telethon Institute, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy
Nat Med 19:1655-60. 2013..genome-wide association studies have identified common variants in the promoter of the UMOD gene, which encodes uromodulin, the major protein secreted in normal urine, that cause independent susceptibility to CKD and hypertension...
- Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or bothLan Mo
Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
Am J Physiol Renal Physiol 293:F1935-43. 2007..Here, we show that 10% of the mice lacking osteopontin (OPN) and 14.3% of the mice lacking Tamm-Horsfall protein (THP) spontaneously form interstitial deposits of calcium phosphate within the renal papillae, events never seen in wild-..
- Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavageSara Santambrogio
Dulbecco Telethon Institute, Molecular Genetics of Renal Disorders, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Biochem Biophys Res Commun 370:410-3. 2008b>Uromodulin (or Tamm-Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion...
- Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanismTarek M El-Achkar
Department of Medicine, Saint Louis University, St Louis, MO, USA
Am J Physiol Renal Physiol 300:F999-1007. 2011Tamm-Horsfall protein (THP) is a glycoprotein expressed exclusively in thick ascending limbs (TAL) of the kidney...
- Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its functionAparna Renigunta
Department of Pediatric Nephrology, Children s Hospital, Philipps University of Marburg, Baldingerstr, 35043 Marburg, Germany
J Biol Chem 286:2224-35. 2011Tamm-Horsfall glycoprotein (THGP) or Uromodulin is a membrane protein exclusively expressed along the thick ascending limb (TAL) and early distal convoluted tubule (DCT) of the nephron...
- Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall proteinYan Liu
Dept of Urology, New York Univ School of Medicine, NY 10010, USA
Am J Physiol Renal Physiol 299:F469-78. 2010..of macromolecule proteins that play critical roles in renal stone formation, among which Tamm-Horsfall protein (THP) is by far the most abundant...
- A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failureIlenia Bernascone
Division of Genetics and Cell Biology, Dulbecco Telethon Institute, Milan, Italy
Hum Mol Genet 19:2998-3010. 2010b>Uromodulin-associated kidney diseases (UAKD) are autosomal-dominant disorders characterized by alteration of urinary concentrating ability, tubulo-interstitial fibrosis, hyperuricaemia and renal cysts at the cortico-medullary junction...
- Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolismElisabeth Kemter
Chair for Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis, Gene Center, Ludwig Maximilians Universitat Munich, Munich, Germany
Am J Physiol Renal Physiol 297:F1391-8. 2009b>Uromodulin-associated kidney disease is a heritable renal disease in humans caused by mutations in the uromodulin (UMOD) gene. The pathogenesis of the disease is mostly unknown...
- Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coliLan Mo
Dept of Urology, New York Univ School of Medicine, 423 East 23 St, 18th Floor, Rm 18064 South, New York, NY 10010, USA
Am J Physiol Renal Physiol 286:F795-802. 2004..In this study, we examined the in vivo role of Tamm-Horsfall protein (THP), the most abundant urinary protein, in innate urinary defense...
- Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterningHortensja Ł Brzóska
Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK
Kidney Int 90:1274-1284. 2016..Thus, PCP genes are important in mammalian kidney development and have an unexpected role in rostrocaudal patterning during organogenesis...
- Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureterZhen X Mahoney
Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 103:19872-7. 2006..Our results suggest that (i) besides its well documented role in regulating epithelial polarity, Dlgh1 also regulates smooth muscle orientation, and (ii) human DLG1 mutations may contribute to hereditary forms of hydronephrosis...
- Role of Prox1 in the Transforming Ascending Thin Limb of Henle's Loop during Mouse Kidney DevelopmentYu Mi Kim
Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea
PLoS ONE 10:e0127429. 2015..Together, these studies suggest that Prox1 appears to be a critical stage specific regulator of specifying ascending thin limb cell fate and that its expression is regulated by osmolality. ..
- Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activityZhenyi Liu
Sage Labs, St Louis, MO 63146, USA Department of Developmental Biology, Washington University, St Louis, MO 63110, USA
Development 142:1193-202. 2015....
- Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil HomeostasisRadmila Micanovic
Divisions of Nephrology and
J Am Soc Nephrol 26:2172-82. 2015Tamm-Horsfall protein (THP) is a glycoprotein uniquely expressed in the kidney...
- Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney diseaseMarion Horsch
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Neuherberg, Germany
PLoS ONE 9:e113125. 2014b>Uromodulin-associated kidney disease (UAKD) is a hereditary progressive renal disease which can lead to renal failure and requires renal replacement therapy...
- Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney diseaseYumay Chen
Department of Medicine, Division of Endocrinology, University of California, Gross Hall 1130, Mail code, 4086, Irvine, CA, 92697, USA
J Biomed Sci 21:63. 2014..Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. Among them, Nek1 is the primary protein inactivated in kat2J mouse models of PKD...
- Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesionAnneliis Ihermann-Hella
Institute of Biotechnology, University of Helsinki, Helsinki, Finland
PLoS Genet 10:e1004193. 2014..We show that MAPK activity is required for branching morphogenesis, and propose that it promotes cell cycle progression and higher cellular motility through remodeling of cellular adhesions. ..
- Alpha-1 acid glycoprotein reduces hepatic leukocyte recruitment in murine models of either early endotoxemia or early sepsisTeresa R McCurdy
Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Canadian Blood Services Research and Development, Hamilton, Ontario, Canada
Microcirculation 21:74-83. 2014..To characterize the effect of systemically administered AGP on early leukocyte recruitment in the livers of endotoxemic or septic mice and to determine whether this is influenced by LPS sequestration...
- Validation of uromodulin as a candidate gene for human essential hypertensionLesley A Graham
Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, United Kingdom
Hypertension 63:551-8. 2014A recent genome-wide association study identified a locus on chromosome 16 in the promoter region of the uromodulin (UMOD) gene that is associated with hypertension...
- Loss of polycystin-1 inhibits Bicc1 expression during mouse developmentPeiwen Lian
Division of Translational Cancer Research and Therapy, State Key Laboratory of Molecular Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 9:e88816. 2014..Our findings demonstrate that Bicc1 is developmentally regulated and reveal a new molecular link between Bicc1 and Pkd1. ..
- Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosisMatthias T F Wolf
Division of Pediatric Nephrology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
Kidney Int 84:130-7. 2013b>Uromodulin (UMOD) is synthesized in the thick ascending limb and secreted into urine as the most abundant protein. Association studies in humans suggest protective effects of UMOD against calcium-containing kidney stones...
- Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injuryTarek M El-Achkar
Division of Nephrology, Indiana University and Roudebush Indianapolis Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
Am J Physiol Renal Physiol 304:F1066-75. 2013Tamm-Horsfall protein (THP) is a glycoprotein normally targeted to the apical membrane domain of the kidney's thick ascending limbs (TAL)...
- Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4Xavier Caubit
Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, Marseille, France
Development 135:3301-10. 2008....
- CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemiaMarchel Stuiver
Department of Pediatric Nephrology, Charite Universitatsmedizin Berlin, Berlin, Germany
Am J Hum Genet 88:333-43. 2011..The mutations found in CNNM2, its observed sensitivity to extracellular Mg(2+), and its basolateral localization signify a critical role for CNNM2 in epithelial Mg(2+) transport...
- Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic miceQing Hua Hu
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, People s Republic of China
Eur J Nutr 51:593-606. 2012Renal organic ion transporters and uromodulin (UMOD) play the important roles in renal urate excretion and function. Hyperuricemia is considered as a risk factor for the development of renal dysfunction...
- Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperonesLijie Ma
Department of Urology, New York University School of Medicine, New York, New York 10016, USA
J Biol Chem 287:1290-305. 2012..Both mutants were able to specifically bind and trap the wild-type Tamm-Horsfall protein (THP) and prevent it from exiting the ER and translocating to the cell surface...
- Changes in the expression of bone morphogenetic protein 7 and tamm- horsfall protein in the early stages of diabetic nephropathyYanchun Qu
Tianjin Institute of Urology, 2nd Hospital of Tianjin Medical University, Tianjin, China
Nephrourol Mon 4:466-9. 2012..Bone morphogenetic protein 7 (BMP7) has been suggested to play a protective role against kidney injury in chronic kidney disease...
- Detection of mutant uromodulin in transgenic mouse harboring a mutant human UMOD geneMakoto Yasuda
Department of Analytical Chemistry, School of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
Nucleosides Nucleotides Nucleic Acids 30:1284-9. 2011b>Uromodulin is the most abundant protein secreted in urine, and the mutated form of the uromodulin gene is associated with uromodulin-associated kidney disease (UAKD)...
- Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degenerationW Wang
The Ronald O Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA
Cell Death Dis 3:e433. 2012Murine Uromodulin-like 1 (Umodl1) encodes Ca(2+)-dependent EGF-like membrane-bound proteins. This study presents its novel expression in the immune and female reproductive systems...
- Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidneyXin Ye
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Development 138:1161-72. 2011....
- Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injuryGunnar Schley
Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
J Am Soc Nephrol 22:2004-15. 2011..of the von Hippel-Lindau protein (Vhl), which mediates HIF degradation under normoxia, using Tamm-Horsfall protein (Thp)-driven Cre expression...
- Pkd1 and Pkd2 are required for normal placental developmentMiguel A Garcia-Gonzalez
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
PLoS ONE 5:. 2010..Cystic kidney disease is unlikely to be the cause of fetal loss since renal function is not required to complete gestation. One hypothesis is that embryonic demise is due to leaky vessels or cardiac pathology...
- Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney diseaseSakura Saburi
Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto M5G 1X5, Canada
Nat Genet 40:1010-5. 2008..In addition, Fat4 represses Fjx1 expression, indicating that Fat signaling is conserved. Together, these data suggest that Fat4 regulates vertebrate PCP and that loss of PCP signaling may underlie some cystic diseases in humans...
- Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebsShalini Jadeja
Molecular Medicine Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
Nat Genet 37:520-5. 2005..This is the only missense mutation reported in any blebbing mutant or individual with Fraser syndrome, suggesting that calcium binding in the CALXbeta-cadherin motif is important for normal functioning of FREM2...
- Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell lineB C Kone
Department of Medicine, University of Florida College of Medicine, Gainesville 32610 0224, USA
Am J Physiol 269:F718-29. 1995..In contrast to other cell types, cycloheximide did not alter iNOS mRNA stability, and 8-BrcAMP did not alter basal or LPS+IF-gamma induced NO production in ST-1 cells...
- Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994N A Doggett
Life Sciences Division, Los Alamos National Laboratory, NM
Cytogenet Cell Genet 68:165-84. 1995
- Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urineK Prasadan
Warren Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City 73104
Biochim Biophys Acta 1260:328-32. 1995The mouse uromodulin cDNA sequence was sequenced...
- Assignment of the Tamm-Horsfall protein/uromodulin gene (Umod) to mouse chromosome bands 7F1-F2 and rat chromosome bands 1q36-->q37 by in situ hybridizationS Fukuoka
The Research Institute for Food Science, Kyoto University, Uji, Japan
Cytogenet Cell Genet 79:241-2. 1997
- Metanephric rat-mouse chimeras to study cell lineage of the nephronL J Arend
Department of Pathology, University of Michigan, Ann Arbor, USA
Dev Genet 24:230-40. 1999..present study evaluated the expression of four relatively well-localized molecules--renin, Tamm-Horsfall protein (THP), oxytocin receptor (OTR), and the vasopressin type 2 receptor (V2R)--in cultured mouse-rat chimeric metanephric ..
- Syndecan-4 deficiency increases susceptibility to kappa-carrageenan-induced renal damageK Ishiguro
Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan
Lab Invest 81:509-16. 2001..After administration of kappa-carrageenan, blood urea nitrogen of Synd4(-/-) mice was significantly higher than that of Synd4(+/+) mice. Thus, syndecan-4 may function to prevent kappa-carrageenan deposition in the collecting ducts...
- Expression of the type IV collagenase system during mouse kidney development and tubule segmentationB Legallicier
INSERM U489, Tenon Hospital and St Antoine Medical Faculty, Paris 6 University, Paris, France
J Am Soc Nephrol 12:2358-69. 2001..These results suggest that a regulated balance of gelatinase activity is required during kidney organogenesis and that gelatinases continue to play a role in adult renal tubule physiology...
- Temporally compartmentalized expression of ephrin-B2 during renal glomerular developmentT Takahashi
Nephrology Division and Center for Vascular Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
J Am Soc Nephrol 12:2673-82. 2001..Thus, the present results suggest that ephrin-B2 and EphB interactions play an important role in glomerular microvascular assembly...
- Isolation of mouse THP gene promoter and demonstration of its kidney-specific activity in transgenic miceXinhua Zhu
Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
Am J Physiol Renal Physiol 282:F608-17. 2002Tamm-Horsfall protein (THP), the most abundant urinary protein synthesized by the kidney epithelial cells, is believed to play important and diverse roles in the urinary system, including renal water balance, immunosuppression, urinary ..
- The use of the uromodulin promoter to target production of recombinant proteins into urine of transgenic animalsHalina M Zbikowska
Plasma Derivative Department, Holland Laboratory, American Red Cross, MD 20855, Rockville, USA
Transgenic Res 11:425-35. 2002A uromodulin promoter has been isolated, sequenced, and used to generate two sets of transgenic mice for expression of the lacZ marker gene and for production of the human recombinant erythropoietin (rhEPO) in urine...
- Restricted expression of mouse GCMa/Gcm1 in kidney and thymusSaid Hashemolhosseini
Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
Mech Dev 118:175-8. 2002..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development...
- Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5Francois Jouret
Division of Nephrology and Laboratory of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
Kidney Int 65:198-208. 2004..However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown...
- GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genomeK Kobayashi
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
Biochem Biophys Res Commun 322:659-64. 2004..Using FISH, the GP2 gene was mapped to mouse chromosome 7F1 near the gene for THP, a GP2 homolog expressed in the cells of thick ascending loop of Henle (TALH) in the kidney...
- Expression of somatostatin in the adult and developing mouse kidneyCarlton M Bates
Center for Human and Molecular Genetics, Children s Research Institute, Columbus, Ohio 43205, USA
Kidney Int 66:1785-93. 2004..Our objective was to determine the expression pattern of SRIF in both the adult and embryonic mouse kidney...
- Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infectionsWenkai Dou
Department of Veterans Affairs Medical Center, Memphis, TN 38104, USA
Am J Physiol Renal Physiol 289:F49-60. 2005..on their ages, the genes encoding pre-pro-epidermal growth factor (pre-pro-EGF) and Tamm-Horsfall protein (THP)/uromodulin were aberrantly expressed in the kidneys of COX-2 -/- mice at all stages of their development...
- FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephronsUta Grieshammer
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
Development 132:3847-57. 2005..Thus, unlike other FGF family members, which regulate growth and branching morphogenesis of the collecting duct system, Fgf8 encodes a factor essential for gene regulation and cell survival at distinct steps in nephrogenesis...
- Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytesJing Chen
Vanderbilt University Medical Center, S3223 MCN, Nashville, TN 37232, USA
J Am Soc Nephrol 17:1283-91. 2006..In the adult kidney, nestin expression is restricted to differentiated podocytes, suggesting that nestin could play an important role in maintaining the structural integrity of the podocytes...
- Tamm-Horsfall protein knockout mice do not develop medullary cystic kidney diseaseH Raffi
Kidney Int 69:1914-5. 2006
- Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouseYoshifumi Yamaguchi
Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Myodaiji, Okazaki, 444 8787, Japan
Development 133:4737-48. 2006..Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney...
- Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1Zakir Hossain
Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Republic of Singapore 138673
Proc Natl Acad Sci U S A 104:1631-6. 2007..Thus, Wwtr1 is critical for the integrity of renal cilia and its absence in mice leads to the development of renal cysts, indicating that Wwtr1 may represent a candidate gene for polycystic kidney disease in humans...
- Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathwayMiguel A Garcia-Gonzalez
Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hum Mol Genet 16:1940-50. 2007..These studies are the first to show genetic interaction between the major loci responsible for human renal cystic disease in a common PKD pathway...
- Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependentTarek M El-Achkar
Indiana Center for Biological Mircroscopy, Department of Medicine, Division of Nephrology, Indiana University, Indianapolis, Indiana 46202, USA
Am J Physiol Renal Physiol 293:F1187-96. 2007..The TLR4-dependent Cox-2 expression is mostly restricted to cortical and medullary thick ascending loops of Henle that characteristically express and secrete Tamm-Horsfall protein...
- Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- miceTamilla Nechiporuk
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Dev Cell 13:338-50. 2007..These findings show that Dlg5 is causally involved in hydrocephalus and renal cysts and reveal that targeted membrane delivery of cadherin-catenin adhesion complexes is critical for cell polarity and epithelial tube maintenance...
- Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneysMonika Trzpis
Department of Pathology and Laboratory Medicine, University Medical Center Groningen UMCG, Groningen, The Netherlands
Nephron Exp Nephrol 107:e119-31. 2007..Furthermore, changes in the EpCAM expression pattern were found in developing lung and thymus and in the regenerating liver. Therefore, EpCAM was proposed to be a morphoregulatory molecule...
- Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expressionTarek M El-Achkar
Department of Medicine, Saint Louis University and St Louis Veterans Affairs Medical Center, St Louis, MO, USA
Am J Physiol Renal Physiol 295:F534-44. 2008Tamm-Horsfall protein (THP) is a glycoprotein with unclear functions expressed exclusively in thick ascending limbs (TAL) of the kidney...
- Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidneyBritta Walter
Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
Histochem Cell Biol 130:943-56. 2008..This prominent cytoplasmic localization of ARVCF in cultured cells and its occurrence in proximal tubules implies an involvement of ARVCF in specific functional processes of proximal tubules of kidney...
- Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymesK Sainio
Department of Pathology, University of Helsinki, Finland
Development 115:827-37. 1992..The latter gene products might be correlated with the physiological activity of the proximal tubules in vivo, as they are not expressed in experimentally induced tubules detectable with markers for proximal tubules...
- Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidneyKylie Georgas
Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, 4072, Australia
Histochem Cell Biol 130:927-42. 2008..We have analysed in detail the protein expression of Wt1, Calb1 Aqp1, Aqp2 and Umod using these antibodies...
- Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubulesHai Lian Shen
Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center, Shanghai, China
Mol Cell Biochem 321:73-83. 2009..In rat kidney LZP and Tamm-Horsfall protein (THP) were co-localized in TAL...
- A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidneyJing Yu
Department of Molecular and Cellular Biology and Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 136:161-71. 2009..These findings demonstrate that Wnt7b is a key regulator of the tissue architecture that establishes a functional physiologically active mammalian kidney...
- Bladder-specific Knockout and Gene ExpressionXue ru Wu; Fiscal Year: 2009..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
- Pathogenic Mechanism of Polycystic Kidney DiseaseYumay Chen; Fiscal Year: 2010..Our studies will provide novel insight into the molecular pathogenesis of PKD. They will help explain why cysts progress at different rates and how therapies to slow the progression of PKD can be designed rationally. ..
- INSULIN RECEPTOR RELATED AND THE KIDNEYCarlton Bates; Fiscal Year: 2002..After being subjected to systemic alkalosis, IRR-null mouse kidneys will be examined to determine if the intercalated cells have appropriately altered their morphology and intracellular distribution of proton transporters. ..
- TEM with Digital and Cryopreparation SystemsAndrew Evan; Fiscal Year: 2003..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
- IKSI: 1st Annual International Urolithiasis Research SymposiumAndrew Evan; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Risk for Renal Injury Caused by Shock Wave LithotripsyAndrew Evan; Fiscal Year: 2008..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
- IKSI: 2nd International Urolithiasis Research SymposiumAndrew Evan; Fiscal Year: 2008..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..