Umod

Summary

Gene Symbol: Umod
Description: uromodulin
Alias: THP, Urehd1, urehr4, uromodulin, Tamm-Horsfall urinary glycoprotein, uromucoid
Species: mouse

Top Publications

  1. pmc Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5055S, Indianapolis, IN 46223, USA
    Urol Res 38:439-52. 2010
  2. ncbi Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation
    H T Yuan
    Nephrourology Unit, Institute of Child Health, University College London, Medical School, United Kingdom
    J Am Soc Nephrol 10:1722-36. 1999
  3. ncbi Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury
    M Tanaka
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Kidney Int 73:181-91. 2008
  4. pmc Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice
    Elisabeth Kemter
    Chair for Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU, Munich, Munich, Germany
    PLoS ONE 8:e78337. 2013
  5. pmc Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap
    Yan Liu
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 287:16365-78. 2012
  6. doi Urinary secretion and extracellular aggregation of mutant uromodulin isoforms
    Céline Schaeffer
    Dulbecco Telethon Institute, San Raffaele Scientific Institute, Milan, Italy
    Kidney Int 81:769-78. 2012
  7. ncbi Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
    Sebastian Bachmann
    Medical Faculty of the Charite, Department of Anatomy, Franz Volhard Clinic, HELIOS Clinics and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Am J Physiol Renal Physiol 288:F559-67. 2005
  8. ncbi Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation
    Lan Mo
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10010, USA
    Kidney Int 66:1159-66. 2004
  9. ncbi Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models
    Bernhard Aigner
    Institute of Molecular Animal Breeding and BiotechnologyInstitute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
    Am J Physiol Renal Physiol 292:F1560-7. 2007
  10. ncbi Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication
    James M Bates
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Kidney Int 65:791-7. 2004

Scientific Experts

  • Shin Ichi Fukuoka
  • L J Arend
  • Tarek M El-Achkar
  • Xue ru Wu
  • Martin W McBride
  • Matthias T F Wolf
  • Yumay Chen
  • M Yasuda
  • H T Yuan
  • Bernhard Aigner
  • S Bachmann
  • Elisabeth Kemter
  • Said Hashemolhosseini
  • CARLTON MATTHEW BATES
  • Andrew E Evan
  • Lan Mo
  • Yan Liu
  • Luca Rampoldi
  • Matteo Trudu
  • Céline Schaeffer
  • Ilenia Bernascone
  • Olivier Devuyst
  • Miguel A Garcia-Gonzalez
  • Kerim Mutig
  • Satish Kumar
  • Adrian S Woolf
  • Sara Santambrogio
  • James M Bates
  • Hortensja Ł Brzóska
  • Zhenyi Liu
  • Radmila Micanovic
  • Yu Mi Kim
  • Marion Horsch
  • Lesley A Graham
  • Anneliis Ihermann-Hella
  • Teresa R McCurdy
  • Peiwen Lian
  • Yanchun Qu
  • Huguette Debaix
  • W Wang
  • Qing Hua Hu
  • Lijie Ma
  • David A Long
  • David L Hasty
  • Masami Ikehata
  • Sylvie Janas
  • Turgay Saritas
  • Marchel Stuiver
  • Aparna Renigunta
  • Xin Ye
  • Gunnar Schley
  • Scott Boyle
  • Angela Cattaneo
  • Angela Bachi
  • Jing Yu
  • Hai Lian Shen
  • David L Huso
  • John C Lieske
  • Terry Watnick
  • Gregory G Germino
  • Luis F Menezes
  • Klaus B Piontek
  • Xavier Caubit
  • Sakura Saburi
  • Kylie Georgas
  • M Tanaka
  • K Ishiguro
  • Britta Walter
  • Monika Trzpis
  • Tamilla Nechiporuk
  • Zakir Hossain
  • Yoshifumi Yamaguchi
  • Jing Chen
  • H Raffi
  • Zhen X Mahoney
  • Matthew D Breyer
  • Shalini Jadeja
  • Wenkai Dou
  • Uta Grieshammer
  • Ellen Shapiro
  • Xin Hua Zhu
  • K Kobayashi
  • Hong Ying Huang
  • Francois Jouret
  • Vishal Patel
  • Eugenia Papakrivopoulou
  • Yunping Lei
  • Mark F Lythgoe
  • Maria Kolatsi-Joannou
  • Richard H Finnell

Detail Information

Publications77

  1. pmc Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice
    Andrew P Evan
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 5055S, Indianapolis, IN 46223, USA
    Urol Res 38:439-52. 2010
    ..Two animal models--the NHERF-1 and THP-null mice--have been shown to develop sites of interstitial apatite plaque in the renal papilla...
  2. ncbi Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturation
    H T Yuan
    Nephrourology Unit, Institute of Child Health, University College London, Medical School, United Kingdom
    J Am Soc Nephrol 10:1722-36. 1999
    ..These data are consistent with the hypothesis that Tie-2 has roles in maturation of both glomeruli and vasa rectae...
  3. ncbi Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury
    M Tanaka
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Kidney Int 73:181-91. 2008
    ..Our study suggests that USAG-1 expression in a kidney biopsy could be useful in predicting outcome...
  4. pmc Standardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice
    Elisabeth Kemter
    Chair for Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU, Munich, Munich, Germany
    PLoS ONE 8:e78337. 2013
    b>Uromodulin-associated kidney disease (UAKD) summarizes different clinical features of an autosomal dominant heritable disease syndrome in humans with a proven uromodulin (UMOD) mutation involved...
  5. pmc Tamm-Horsfall protein regulates circulating and renal cytokines by affecting glomerular filtration rate and acting as a urinary cytokine trap
    Yan Liu
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 287:16365-78. 2012
    ..Here we show that elimination of Tamm-Horsfall protein (THP) expression from mouse kidneys caused a marked elevation of circulating IFN-γ, IL1α, TNF-α, IL6, CXCL1, and IL13...
  6. doi Urinary secretion and extracellular aggregation of mutant uromodulin isoforms
    Céline Schaeffer
    Dulbecco Telethon Institute, San Raffaele Scientific Institute, Milan, Italy
    Kidney Int 81:769-78. 2012
    b>Uromodulin is exclusively expressed in the thick ascending limb and is the most abundant protein secreted in urine where it is found in high-molecular-weight polymers...
  7. ncbi Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
    Sebastian Bachmann
    Medical Faculty of the Charite, Department of Anatomy, Franz Volhard Clinic, HELIOS Clinics and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Am J Physiol Renal Physiol 288:F559-67. 2005
    The Tamm-Horsfall protein (THP; uromodulin), the dominant protein in normal urine, is produced exclusively in the thick ascending limb of Henle's loop...
  8. ncbi Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation
    Lan Mo
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10010, USA
    Kidney Int 66:1159-66. 2004
    ..Here we examined the role of Tamm-Horsfall protein (THP), the principal urinary protein, in urinary defense against renal calcium crystal formation, using a THP knockout ..
  9. ncbi Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models
    Bernhard Aigner
    Institute of Molecular Animal Breeding and BiotechnologyInstitute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
    Am J Physiol Renal Physiol 292:F1560-7. 2007
    ....
  10. ncbi Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication
    James M Bates
    Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Kidney Int 65:791-7. 2004
    ..Factors involved in clearing bacteria from the urinary tract are poorly understood. Tamm-Horsfall protein (THP), the most abundant protein in mammalian urine, has been postulated to play a role in defense against urinary tract ..
  11. pmc Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner
    Kerim Mutig
    Department of Anatomy, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Biol Chem 286:30200-10. 2011
    ..Co-expressed Tamm-Horsfall protein (THP) has been proposed to interact with NKCC2. We hypothesized that THP modulates NKCC2 activity in TAL...
  12. pmc Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression
    Matteo Trudu
    Dulbecco Telethon Institute, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy
    Nat Med 19:1655-60. 2013
    ..genome-wide association studies have identified common variants in the promoter of the UMOD gene, which encodes uromodulin, the major protein secreted in normal urine, that cause independent susceptibility to CKD and hypertension...
  13. ncbi Renal calcinosis and stone formation in mice lacking osteopontin, Tamm-Horsfall protein, or both
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, Veterans Affairs Medical Center in Manhattan, 423 E23 St, Rm 18064S, New York, NY 10010, USA
    Am J Physiol Renal Physiol 293:F1935-43. 2007
    ..Here, we show that 10% of the mice lacking osteopontin (OPN) and 14.3% of the mice lacking Tamm-Horsfall protein (THP) spontaneously form interstitial deposits of calcium phosphate within the renal papillae, events never seen in wild-..
  14. doi Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage
    Sara Santambrogio
    Dulbecco Telethon Institute, Molecular Genetics of Renal Disorders, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Biochem Biophys Res Commun 370:410-3. 2008
    b>Uromodulin (or Tamm-Horsfall protein) is the most abundant protein in human urine under physiological conditions. Little is known about the molecular mechanism of uromodulin secretion...
  15. doi Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an MIP-2-dependent mechanism
    Tarek M El-Achkar
    Department of Medicine, Saint Louis University, St Louis, MO, USA
    Am J Physiol Renal Physiol 300:F999-1007. 2011
    Tamm-Horsfall protein (THP) is a glycoprotein expressed exclusively in thick ascending limbs (TAL) of the kidney...
  16. pmc Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function
    Aparna Renigunta
    Department of Pediatric Nephrology, Children s Hospital, Philipps University of Marburg, Baldingerstr, 35043 Marburg, Germany
    J Biol Chem 286:2224-35. 2011
    Tamm-Horsfall glycoprotein (THGP) or Uromodulin is a membrane protein exclusively expressed along the thick ascending limb (TAL) and early distal convoluted tubule (DCT) of the nephron...
  17. pmc Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein
    Yan Liu
    Dept of Urology, New York Univ School of Medicine, NY 10010, USA
    Am J Physiol Renal Physiol 299:F469-78. 2010
    ..of macromolecule proteins that play critical roles in renal stone formation, among which Tamm-Horsfall protein (THP) is by far the most abundant...
  18. doi A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure
    Ilenia Bernascone
    Division of Genetics and Cell Biology, Dulbecco Telethon Institute, Milan, Italy
    Hum Mol Genet 19:2998-3010. 2010
    b>Uromodulin-associated kidney diseases (UAKD) are autosomal-dominant disorders characterized by alteration of urinary concentrating ability, tubulo-interstitial fibrosis, hyperuricaemia and renal cysts at the cortico-medullary junction...
  19. doi Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism
    Elisabeth Kemter
    Chair for Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis, Gene Center, Ludwig Maximilians Universitat Munich, Munich, Germany
    Am J Physiol Renal Physiol 297:F1391-8. 2009
    b>Uromodulin-associated kidney disease is a heritable renal disease in humans caused by mutations in the uromodulin (UMOD) gene. The pathogenesis of the disease is mostly unknown...
  20. ncbi Ablation of the Tamm-Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli
    Lan Mo
    Dept of Urology, New York Univ School of Medicine, 423 East 23 St, 18th Floor, Rm 18064 South, New York, NY 10010, USA
    Am J Physiol Renal Physiol 286:F795-802. 2004
    ..In this study, we examined the in vivo role of Tamm-Horsfall protein (THP), the most abundant urinary protein, in innate urinary defense...
  21. pmc Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning
    Hortensja Ł Brzóska
    Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, UK
    Kidney Int 90:1274-1284. 2016
    ..Thus, PCP genes are important in mammalian kidney development and have an unexpected role in rostrocaudal patterning during organogenesis...
  22. pmc Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter
    Zhen X Mahoney
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:19872-7. 2006
    ..Our results suggest that (i) besides its well documented role in regulating epithelial polarity, Dlgh1 also regulates smooth muscle orientation, and (ii) human DLG1 mutations may contribute to hereditary forms of hydronephrosis...
  23. pmc Role of Prox1 in the Transforming Ascending Thin Limb of Henle's Loop during Mouse Kidney Development
    Yu Mi Kim
    Department of Anatomy and Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea
    PLoS ONE 10:e0127429. 2015
    ..Together, these studies suggest that Prox1 appears to be a critical stage specific regulator of specifying ascending thin limb cell fate and that its expression is regulated by osmolality. ..
  24. pmc Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity
    Zhenyi Liu
    Sage Labs, St Louis, MO 63146, USA Department of Developmental Biology, Washington University, St Louis, MO 63110, USA
    Development 142:1193-202. 2015
    ....
  25. pmc Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis
    Radmila Micanovic
    Divisions of Nephrology and
    J Am Soc Nephrol 26:2172-82. 2015
    Tamm-Horsfall protein (THP) is a glycoprotein uniquely expressed in the kidney...
  26. pmc Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney disease
    Marion Horsch
    German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 9:e113125. 2014
    b>Uromodulin-associated kidney disease (UAKD) is a hereditary progressive renal disease which can lead to renal failure and requires renal replacement therapy...
  27. pmc Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease
    Yumay Chen
    Department of Medicine, Division of Endocrinology, University of California, Gross Hall 1130, Mail code, 4086, Irvine, CA, 92697, USA
    J Biomed Sci 21:63. 2014
    ..Neks, mammalian orthologs of the fungal protein kinase never-in-mitosis A, have been implicated in the pathogenesis of polycystic kidney disease. Among them, Nek1 is the primary protein inactivated in kat2J mouse models of PKD...
  28. pmc Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion
    Anneliis Ihermann-Hella
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    PLoS Genet 10:e1004193. 2014
    ..We show that MAPK activity is required for branching morphogenesis, and propose that it promotes cell cycle progression and higher cellular motility through remodeling of cellular adhesions. ..
  29. doi Alpha-1 acid glycoprotein reduces hepatic leukocyte recruitment in murine models of either early endotoxemia or early sepsis
    Teresa R McCurdy
    Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada Canadian Blood Services Research and Development, Hamilton, Ontario, Canada
    Microcirculation 21:74-83. 2014
    ..To characterize the effect of systemically administered AGP on early leukocyte recruitment in the livers of endotoxemic or septic mice and to determine whether this is influenced by LPS sequestration...
  30. doi Validation of uromodulin as a candidate gene for human essential hypertension
    Lesley A Graham
    Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, United Kingdom
    Hypertension 63:551-8. 2014
    A recent genome-wide association study identified a locus on chromosome 16 in the promoter region of the uromodulin (UMOD) gene that is associated with hypertension...
  31. pmc Loss of polycystin-1 inhibits Bicc1 expression during mouse development
    Peiwen Lian
    Division of Translational Cancer Research and Therapy, State Key Laboratory of Molecular Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS ONE 9:e88816. 2014
    ..Our findings demonstrate that Bicc1 is developmentally regulated and reveal a new molecular link between Bicc1 and Pkd1. ..
  32. pmc Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis
    Matthias T F Wolf
    Division of Pediatric Nephrology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    Kidney Int 84:130-7. 2013
    b>Uromodulin (UMOD) is synthesized in the thick ascending limb and secreted into urine as the most abundant protein. Association studies in humans suggest protective effects of UMOD against calcium-containing kidney stones...
  33. pmc Tamm-Horsfall protein translocates to the basolateral domain of thick ascending limbs, interstitium, and circulation during recovery from acute kidney injury
    Tarek M El-Achkar
    Division of Nephrology, Indiana University and Roudebush Indianapolis Veterans Affairs Medical Center, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 304:F1066-75. 2013
    Tamm-Horsfall protein (THP) is a glycoprotein normally targeted to the apical membrane domain of the kidney's thick ascending limbs (TAL)...
  34. doi Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4
    Xavier Caubit
    Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS, Universite de la Mediterranee, Marseille, France
    Development 135:3301-10. 2008
    ....
  35. pmc CNNM2, encoding a basolateral protein required for renal Mg2+ handling, is mutated in dominant hypomagnesemia
    Marchel Stuiver
    Department of Pediatric Nephrology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Hum Genet 88:333-43. 2011
    ..The mutations found in CNNM2, its observed sensitivity to extracellular Mg(2+), and its basolateral localization signify a critical role for CNNM2 in epithelial Mg(2+) transport...
  36. doi Quercetin regulates organic ion transporter and uromodulin expression and improves renal function in hyperuricemic mice
    Qing Hua Hu
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, People s Republic of China
    Eur J Nutr 51:593-606. 2012
    Renal organic ion transporters and uromodulin (UMOD) play the important roles in renal urate excretion and function. Hyperuricemia is considered as a risk factor for the development of renal dysfunction...
  37. pmc Molecular and cellular effects of Tamm-Horsfall protein mutations and their rescue by chemical chaperones
    Lijie Ma
    Department of Urology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 287:1290-305. 2012
    ..Both mutants were able to specifically bind and trap the wild-type Tamm-Horsfall protein (THP) and prevent it from exiting the ER and translocating to the cell surface...
  38. pmc Changes in the expression of bone morphogenetic protein 7 and tamm- horsfall protein in the early stages of diabetic nephropathy
    Yanchun Qu
    Tianjin Institute of Urology, 2nd Hospital of Tianjin Medical University, Tianjin, China
    Nephrourol Mon 4:466-9. 2012
    ..Bone morphogenetic protein 7 (BMP7) has been suggested to play a protective role against kidney injury in chronic kidney disease...
  39. doi Detection of mutant uromodulin in transgenic mouse harboring a mutant human UMOD gene
    Makoto Yasuda
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan
    Nucleosides Nucleotides Nucleic Acids 30:1284-9. 2011
    b>Uromodulin is the most abundant protein secreted in urine, and the mutated form of the uromodulin gene is associated with uromodulin-associated kidney disease (UAKD)...
  40. pmc Overexpression of Uromodulin-like1 accelerates follicle depletion and subsequent ovarian degeneration
    W Wang
    The Ronald O Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cell Death Dis 3:e433. 2012
    Murine Uromodulin-like 1 (Umodl1) encodes Ca(2+)-dependent EGF-like membrane-bound proteins. This study presents its novel expression in the immune and female reproductive systems...
  41. pmc Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney
    Xin Ye
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Development 138:1161-72. 2011
    ....
  42. pmc Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury
    Gunnar Schley
    Department of Nephrology and Hypertension, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Am Soc Nephrol 22:2004-15. 2011
    ..of the von Hippel-Lindau protein (Vhl), which mediates HIF degradation under normoxia, using Tamm-Horsfall protein (Thp)-driven Cre expression...
  43. pmc Pkd1 and Pkd2 are required for normal placental development
    Miguel A Garcia-Gonzalez
    Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS ONE 5:. 2010
    ..Cystic kidney disease is unlikely to be the cause of fetal loss since renal function is not required to complete gestation. One hypothesis is that embryonic demise is due to leaky vessels or cardiac pathology...
  44. doi Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
    Sakura Saburi
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto M5G 1X5, Canada
    Nat Genet 40:1010-5. 2008
    ..In addition, Fat4 represses Fjx1 expression, indicating that Fat signaling is conserved. Together, these data suggest that Fat4 regulates vertebrate PCP and that loss of PCP signaling may underlie some cystic diseases in humans...
  45. ncbi Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs
    Shalini Jadeja
    Molecular Medicine Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Nat Genet 37:520-5. 2005
    ..This is the only missense mutation reported in any blebbing mutant or individual with Fraser syndrome, suggesting that calcium binding in the CALXbeta-cadherin motif is important for normal functioning of FREM2...
  46. ncbi Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line
    B C Kone
    Department of Medicine, University of Florida College of Medicine, Gainesville 32610 0224, USA
    Am J Physiol 269:F718-29. 1995
    ..In contrast to other cell types, cycloheximide did not alter iNOS mRNA stability, and 8-BrcAMP did not alter basal or LPS+IF-gamma induced NO production in ST-1 cells...
  47. ncbi Report and abstracts of the third international workshop on human chromosome 16 mapping 1994. Pittsburgh, Pennsylvania, May 7-9, 1994
    N A Doggett
    Life Sciences Division, Los Alamos National Laboratory, NM
    Cytogenet Cell Genet 68:165-84. 1995
  48. ncbi Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein)--the most abundant protein in mammalian urine
    K Prasadan
    Warren Medical Research Institute, University of Oklahoma Health Sciences Center, Oklahoma City 73104
    Biochim Biophys Acta 1260:328-32. 1995
    The mouse uromodulin cDNA sequence was sequenced...
  49. ncbi Assignment of the Tamm-Horsfall protein/uromodulin gene (Umod) to mouse chromosome bands 7F1-F2 and rat chromosome bands 1q36-->q37 by in situ hybridization
    S Fukuoka
    The Research Institute for Food Science, Kyoto University, Uji, Japan
    Cytogenet Cell Genet 79:241-2. 1997
  50. ncbi Metanephric rat-mouse chimeras to study cell lineage of the nephron
    L J Arend
    Department of Pathology, University of Michigan, Ann Arbor, USA
    Dev Genet 24:230-40. 1999
    ..present study evaluated the expression of four relatively well-localized molecules--renin, Tamm-Horsfall protein (THP), oxytocin receptor (OTR), and the vasopressin type 2 receptor (V2R)--in cultured mouse-rat chimeric metanephric ..
  51. ncbi Syndecan-4 deficiency increases susceptibility to kappa-carrageenan-induced renal damage
    K Ishiguro
    Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan
    Lab Invest 81:509-16. 2001
    ..After administration of kappa-carrageenan, blood urea nitrogen of Synd4(-/-) mice was significantly higher than that of Synd4(+/+) mice. Thus, syndecan-4 may function to prevent kappa-carrageenan deposition in the collecting ducts...
  52. ncbi Expression of the type IV collagenase system during mouse kidney development and tubule segmentation
    B Legallicier
    INSERM U489, Tenon Hospital and St Antoine Medical Faculty, Paris 6 University, Paris, France
    J Am Soc Nephrol 12:2358-69. 2001
    ..These results suggest that a regulated balance of gelatinase activity is required during kidney organogenesis and that gelatinases continue to play a role in adult renal tubule physiology...
  53. ncbi Temporally compartmentalized expression of ephrin-B2 during renal glomerular development
    T Takahashi
    Nephrology Division and Center for Vascular Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Am Soc Nephrol 12:2673-82. 2001
    ..Thus, the present results suggest that ephrin-B2 and EphB interactions play an important role in glomerular microvascular assembly...
  54. ncbi Isolation of mouse THP gene promoter and demonstration of its kidney-specific activity in transgenic mice
    Xinhua Zhu
    Department of Urology, Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York 10016, USA
    Am J Physiol Renal Physiol 282:F608-17. 2002
    Tamm-Horsfall protein (THP), the most abundant urinary protein synthesized by the kidney epithelial cells, is believed to play important and diverse roles in the urinary system, including renal water balance, immunosuppression, urinary ..
  55. ncbi The use of the uromodulin promoter to target production of recombinant proteins into urine of transgenic animals
    Halina M Zbikowska
    Plasma Derivative Department, Holland Laboratory, American Red Cross, MD 20855, Rockville, USA
    Transgenic Res 11:425-35. 2002
    A uromodulin promoter has been isolated, sequenced, and used to generate two sets of transgenic mice for expression of the lacZ marker gene and for production of the human recombinant erythropoietin (rhEPO) in urine...
  56. ncbi Restricted expression of mouse GCMa/Gcm1 in kidney and thymus
    Said Hashemolhosseini
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Mech Dev 118:175-8. 2002
    ..In thymus, mGCMa is restricted to few small clusters of cells, in kidney to the S3 segment of proximal tubules. mGCMa expression is primarily postnatal, arguing for a role in organ function rather than organ development...
  57. ncbi Comparative ontogeny, processing, and segmental distribution of the renal chloride channel, ClC-5
    Francois Jouret
    Division of Nephrology and Laboratory of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Kidney Int 65:198-208. 2004
    ..However, the ontogeny of ClC-5, and its processing and segmental distribution with respect to related proteins during nephrogenesis remain unknown...
  58. ncbi GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome
    K Kobayashi
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Biochem Biophys Res Commun 322:659-64. 2004
    ..Using FISH, the GP2 gene was mapped to mouse chromosome 7F1 near the gene for THP, a GP2 homolog expressed in the cells of thick ascending loop of Henle (TALH) in the kidney...
  59. ncbi Expression of somatostatin in the adult and developing mouse kidney
    Carlton M Bates
    Center for Human and Molecular Genetics, Children s Research Institute, Columbus, Ohio 43205, USA
    Kidney Int 66:1785-93. 2004
    ..Our objective was to determine the expression pattern of SRIF in both the adult and embryonic mouse kidney...
  60. ncbi Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections
    Wenkai Dou
    Department of Veterans Affairs Medical Center, Memphis, TN 38104, USA
    Am J Physiol Renal Physiol 289:F49-60. 2005
    ..on their ages, the genes encoding pre-pro-epidermal growth factor (pre-pro-EGF) and Tamm-Horsfall protein (THP)/uromodulin were aberrantly expressed in the kidneys of COX-2 -/- mice at all stages of their development...
  61. ncbi FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons
    Uta Grieshammer
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 132:3847-57. 2005
    ..Thus, unlike other FGF family members, which regulate growth and branching morphogenesis of the collecting duct system, Fgf8 encodes a factor essential for gene regulation and cell survival at distinct steps in nephrogenesis...
  62. ncbi Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes
    Jing Chen
    Vanderbilt University Medical Center, S3223 MCN, Nashville, TN 37232, USA
    J Am Soc Nephrol 17:1283-91. 2006
    ..In the adult kidney, nestin expression is restricted to differentiated podocytes, suggesting that nestin could play an important role in maintaining the structural integrity of the podocytes...
  63. ncbi Tamm-Horsfall protein knockout mice do not develop medullary cystic kidney disease
    H Raffi
    Kidney Int 69:1914-5. 2006
  64. ncbi Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse
    Yoshifumi Yamaguchi
    Okazaki Institute for Integrative Biosciences, National Institutes of Natural Sciences, Myodaiji, Okazaki, 444 8787, Japan
    Development 133:4737-48. 2006
    ..Furthermore, the composition of saliva and urine was abnormal in these mice. These results indicate that Cp2l1 expression is required for normal duct development in both the salivary gland and kidney...
  65. pmc Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1
    Zakir Hossain
    Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Republic of Singapore 138673
    Proc Natl Acad Sci U S A 104:1631-6. 2007
    ..Thus, Wwtr1 is critical for the integrity of renal cilia and its absence in mice leads to the development of renal cysts, indicating that Wwtr1 may represent a candidate gene for polycystic kidney disease in humans...
  66. pmc Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway
    Miguel A Garcia-Gonzalez
    Department of Medicine, Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 16:1940-50. 2007
    ..These studies are the first to show genetic interaction between the major loci responsible for human renal cystic disease in a common PKD pathway...
  67. ncbi Sepsis induces an increase in thick ascending limb Cox-2 that is TLR4 dependent
    Tarek M El-Achkar
    Indiana Center for Biological Mircroscopy, Department of Medicine, Division of Nephrology, Indiana University, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 293:F1187-96. 2007
    ..The TLR4-dependent Cox-2 expression is mostly restricted to cortical and medullary thick ascending loops of Henle that characteristically express and secrete Tamm-Horsfall protein...
  68. pmc Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice
    Tamilla Nechiporuk
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Dev Cell 13:338-50. 2007
    ..These findings show that Dlg5 is causally involved in hydrocephalus and renal cysts and reveal that targeted membrane delivery of cadherin-catenin adhesion complexes is critical for cell polarity and epithelial tube maintenance...
  69. ncbi Spatial and temporal expression patterns of the epithelial cell adhesion molecule (EpCAM/EGP-2) in developing and adult kidneys
    Monika Trzpis
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen UMCG, Groningen, The Netherlands
    Nephron Exp Nephrol 107:e119-31. 2007
    ..Furthermore, changes in the EpCAM expression pattern were found in developing lung and thymus and in the regenerating liver. Therefore, EpCAM was proposed to be a morphoregulatory molecule...
  70. doi Tamm-Horsfall protein protects the kidney from ischemic injury by decreasing inflammation and altering TLR4 expression
    Tarek M El-Achkar
    Department of Medicine, Saint Louis University and St Louis Veterans Affairs Medical Center, St Louis, MO, USA
    Am J Physiol Renal Physiol 295:F534-44. 2008
    Tamm-Horsfall protein (THP) is a glycoprotein with unclear functions expressed exclusively in thick ascending limbs (TAL) of the kidney...
  71. doi Differential expression pattern of protein ARVCF in nephron segments of human and mouse kidney
    Britta Walter
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Histochem Cell Biol 130:943-56. 2008
    ..This prominent cytoplasmic localization of ARVCF in cultured cells and its occurrence in proximal tubules implies an involvement of ARVCF in specific functional processes of proximal tubules of kidney...
  72. ncbi Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes
    K Sainio
    Department of Pathology, University of Helsinki, Finland
    Development 115:827-37. 1992
    ..The latter gene products might be correlated with the physiological activity of the proximal tubules in vivo, as they are not expressed in experimentally induced tubules detectable with markers for proximal tubules...
  73. doi Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney
    Kylie Georgas
    Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, 4072, Australia
    Histochem Cell Biol 130:927-42. 2008
    ..We have analysed in detail the protein expression of Wt1, Calb1 Aqp1, Aqp2 and Umod using these antibodies...
  74. doi Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules
    Hai Lian Shen
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center, Shanghai, China
    Mol Cell Biochem 321:73-83. 2009
    ..In rat kidney LZP and Tamm-Horsfall protein (THP) were co-localized in TAL...
  75. pmc A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney
    Jing Yu
    Department of Molecular and Cellular Biology and Harvard Stem Cell Institute, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 136:161-71. 2009
    ..These findings demonstrate that Wnt7b is a key regulator of the tissue architecture that establishes a functional physiologically active mammalian kidney...

Research Grants7

  1. Bladder-specific Knockout and Gene Expression
    Xue ru Wu; Fiscal Year: 2009
    ..These studies will generate powerful experimental tools for studying bladder biology and diseases and offer molecular insights regarding urothelial growth and tumorigenesis. ..
  2. Pathogenic Mechanism of Polycystic Kidney Disease
    Yumay Chen; Fiscal Year: 2010
    ..Our studies will provide novel insight into the molecular pathogenesis of PKD. They will help explain why cysts progress at different rates and how therapies to slow the progression of PKD can be designed rationally. ..
  3. INSULIN RECEPTOR RELATED AND THE KIDNEY
    Carlton Bates; Fiscal Year: 2002
    ..After being subjected to systemic alkalosis, IRR-null mouse kidneys will be examined to determine if the intercalated cells have appropriately altered their morphology and intracellular distribution of proton transporters. ..
  4. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  5. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  7. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..