Ucp3

Summary

Gene Symbol: Ucp3
Description: uncoupling protein 3 (mitochondrial, proton carrier)
Alias: AI645527, Slc25a9, UCP-3, mitochondrial uncoupling protein 3, UCP 3, solute carrier family 25 member 9, uncoupling protein 3, mitochondrial
Species: mouse

Top Publications

  1. pmc UCP3 translocates lipid hydroperoxide and mediates lipid hydroperoxide-dependent mitochondrial uncoupling
    Assunta Lombardi
    Dipartimento delle Scienze Biologiche, Universita degli Studi di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
    J Biol Chem 285:16599-605. 2010
  2. doi The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress
    Andrea Anedda
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, 28006 Madrid, Spain
    Free Radic Biol Med 61:395-407. 2013
  3. ncbi Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart
    M E Young
    Division of Cardiology, Department of Integrative Biology, University of Texas Houston Medical Center, Houston, Texas 77030, USA
    FASEB J 15:833-45. 2001
  4. ncbi In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism
    G W Cline
    Department of Internal Medicine and the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    J Biol Chem 276:20240-4. 2001
  5. ncbi Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice
    V Bezaire
    Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Am J Physiol Endocrinol Metab 281:E975-82. 2001
  6. ncbi Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
    J C Clapham
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Nature 406:415-8. 2000
  7. ncbi Superoxide activates mitochondrial uncoupling proteins
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Nature 415:96-9. 2002
  8. ncbi Energy metabolism in uncoupling protein 3 gene knockout mice
    A J Vidal-Puig
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:16258-66. 2000
  9. ncbi Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:16251-7. 2000
  10. doi Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration
    Ryan J Mailloux
    Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Canada
    Biochem J 437:301-11. 2011

Scientific Experts

Detail Information

Publications93

  1. pmc UCP3 translocates lipid hydroperoxide and mediates lipid hydroperoxide-dependent mitochondrial uncoupling
    Assunta Lombardi
    Dipartimento delle Scienze Biologiche, Universita degli Studi di Napoli Federico II, Via Mezzocannone 8, 80134 Napoli, Italy
    J Biol Chem 285:16599-605. 2010
    Although the literature contains many studies on the function of UCP3, its role is still being debated...
  2. doi The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress
    Andrea Anedda
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, 28006 Madrid, Spain
    Free Radic Biol Med 61:395-407. 2013
    Uncoupling protein 3 (UCP3) is a member of the mitochondrial inner membrane carrier superfamily that modulates energy efficiency by catalyzing proton conductance and thus decreasing the production of superoxide anion...
  3. ncbi Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart
    M E Young
    Division of Cardiology, Department of Integrative Biology, University of Texas Houston Medical Center, Houston, Texas 77030, USA
    FASEB J 15:833-45. 2001
    ..These results suggest that in the adult rodent heart, UCP-3 expression is regulated by PPARalpha. In contrast, cardiac UCP-2 expression is regulated in part by a fatty acid-dependent, PPARalpha-independent mechanism...
  4. ncbi In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism
    G W Cline
    Department of Internal Medicine and the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    J Biol Chem 276:20240-4. 2001
    To clarify the role of uncoupling protein-3 (UCP3) in skeletal muscle, we used NMR and isotopic labeling experiments to evaluate the effect of UCP3 knockout (UCP3KO) in mice on the regulation of energy metabolism in vivo...
  5. ncbi Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice
    V Bezaire
    Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Am J Physiol Endocrinol Metab 281:E975-82. 2001
    Uncoupling protein-3 (UCP3) is a mitochondrial carrier protein of as yet undefined physiological function...
  6. ncbi Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
    J C Clapham
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK
    Nature 406:415-8. 2000
    ..This provides evidence that skeletal muscle UCP-3 has the potential to influence metabolic rate and glucose homeostasis in the whole animal...
  7. ncbi Superoxide activates mitochondrial uncoupling proteins
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Nature 415:96-9. 2002
    ..The functions of its homologues, UCP2 and UCP3, in other tissues are debated...
  8. ncbi Energy metabolism in uncoupling protein 3 gene knockout mice
    A J Vidal-Puig
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:16258-66. 2000
    Uncoupling protein 3 (UCP3) is a member of the mitochondrial anion carrier superfamily...
  9. ncbi Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:16251-7. 2000
    Uncoupling protein-3 (UCP3) is a mitochondrial protein that can diminish the mitochondrial membrane potential. Levels of muscle Ucp3 mRNA are increased by thyroid hormone and fasting...
  10. doi Hexokinase II acts through UCP3 to suppress mitochondrial reactive oxygen species production and maintain aerobic respiration
    Ryan J Mailloux
    Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Canada
    Biochem J 437:301-11. 2011
    b>UCP3 (uncoupling protein-3) mitigates mitochondrial ROS (reactive oxygen species) production, but the mechanisms are poorly understood...
  11. pmc Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning
    Cevher Ozcan
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Physiol Heart Circ Physiol 304:H1192-200. 2013
    ..Cardiac UCP3 knockout (UCP3(-/-)) and wild-type (WT) mice hearts were subjected to ex vivo and in vivo models of I/R injury and ..
  12. pmc Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure
    Cinzia Perrino
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    J Am Heart Assoc 2:e000086. 2013
    Uncoupling protein 3 (ucp3) is a member of the mitochondrial anion carrier superfamily of proteins uncoupling mitochondrial respiration...
  13. pmc A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
    Karim S Echtay
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    EMBO J 22:4103-10. 2003
    ..and other 2-alkenals) specifically induce uncoupling of mitochondria through the uncoupling proteins UCP1, UCP2 and UCP3 and the adenine nucleotide translocase (ANT)...
  14. ncbi Uncoupling protein 3 protects aconitase against inactivation in isolated skeletal muscle mitochondria
    Darren A Talbot
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochim Biophys Acta 1709:150-6. 2005
    ..Activators include superoxide and reactive alkenals, suggesting new physiological functions for UCP2 and UCP3: their activation by superoxide when protonmotive force is high causes mild uncoupling, which lowers protonmotive ..
  15. doi The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice
    Miranda Nabben
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    FEBS Lett 582:4147-52. 2008
    Uncoupling protein 3 (UCP3) is suggested to protect mitochondria against aging and lipid-induced damage, possibly via modulation of reactive oxygen species (ROS) production...
  16. doi Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export
    Erin L Seifert
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Biol Chem 283:25124-31. 2008
    Uncoupling protein-3 (UCP3) is a mitochondrial inner membrane protein expressed most abundantly in skeletal muscle and to a lesser extent in heart and brown adipose tissue...
  17. pmc ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3
    Zhongping Lu
    Translational Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 283:23410-8. 2008
    Hypoxia induces oxidative damage in skeletal muscle. Uncoupling protein 3 (UCP3) is the skeletal muscle enriched uncoupling protein and has previously been shown to confer resistance against oxidative stress...
  18. ncbi Induction of endogenous uncoupling protein 3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration
    Ethan J Anderson
    John B Pierce Laboratory and Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06519, USA
    J Biol Chem 282:31257-66. 2007
    Uncoupling protein 3 (UCP3) expression increases dramatically in skeletal muscle under metabolic states associated with elevated lipid metabolism, yet the function of UCP3 in a physiological context remains controversial...
  19. ncbi Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1770, USA
    J Biol Chem 272:24129-32. 1997
    ..We have cloned a third member of the UCP family, UCP3. UCP3 is expressed at high levels in muscle and rodent brown adipose tissue...
  20. pmc Vitamin D3/VDR resists diet-induced obesity by modulating UCP3 expression in muscles
    Yue Fan
    Department of Medicine and Clinical Science, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, 663 8179, Japan
    J Biomed Sci 23:56. 2016
    ..The impact of vitamin D3 (VD3) on obesity has been reported in the past. Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet...
  21. pmc Protective Effect of Peroxisome Proliferator-Activated Receptor α Activation against Cardiac Ischemia-Reperfusion Injury Is Related to Upregulation of Uncoupling Protein-3
    Jong Wook Song
    Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
    Oxid Med Cell Longev 2016:3539649. 2016
    ..WY-14643 increased UCP3 expression in vivo. Myocardial infarct size was decreased in the WY-14643 group (76 ± 8% versus 42 ± 12%, P<0...
  22. pmc Genetic deletion in uncoupling protein 3 augments 18F-fluorodeoxyglucose cardiac uptake in the ischemic heart
    Sara Gargiulo
    Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy
    BMC Cardiovasc Disord 14:98. 2014
    We investigated the effects of uncoupling protein 3 (UCP3) genetic deletion on 18F-fluorodeoxyglucose (FDG) cardiac uptake by positron emission tomography (PET)/computed tomography (CT) dedicated animal system after permanent coronary ..
  23. pmc Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis
    Parjam S Zolfaghari
    Bloomsbury Institute for Intensive Care Medicine, University College London, London, United Kingdom Department of Cell and Developmental Biology, University College London, London, United Kingdom
    Am J Physiol Endocrinol Metab 308:E713-25. 2015
    ..Increased abundance of uncoupling protein-3 (UCP3) in sepsis suggests increased mitochondrial proton leak, which may reduce mitochondrial coupling efficiency but ..
  24. pmc Muscle uncoupling protein 3 overexpression mimics endurance training and reduces circulating biomarkers of incomplete β-oxidation
    Celine Aguer
    2M E H, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
    FASEB J 27:4213-25. 2013
    ..Uncoupling protein 3 (UCP3) is a mitochondrial inner membrane protein highly selectively expressed in skeletal muscle...
  25. doi Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle
    Yu Kitaoka
    a Department of Sports Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902, Japan
    Appl Physiol Nutr Metab 41:695-8. 2016
    ..USA). Among the top 15 genes with the largest fold change, increased expression of Ppargc1a, Pdk4, and Ucp3 was confirmed using real-time quantitative polymerase chain reaction...
  26. pmc Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway
    Dajun Liu
    Division of Nephrology Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e36994. 2012
    ..STC1 localizes to the inner mitochondrial membrane and transgenic over-expression of STC1 is associated with increased energy utilization...
  27. pmc Glutaredoxin-2 is required to control proton leak through uncoupling protein-3
    Ryan J Mailloux
    Department of Biochemistry, Immunology, and Microbiology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 288:8365-79. 2013
    ..Recently, we showed that the glutathionylation state of uncoupling protein-3 (UCP3) modulates the leak of protons back into the mitochondrial matrix, thus controlling reactive oxygen species ..
  28. pmc Imprinted gene dosage is critical for the transition to independent life
    Marika Charalambous
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Cell Metab 15:209-21. 2012
    ..This shows that appropriate dosage control at imprinted loci can act as a critical determinant in postnatal survival during phases of physiological adaptation...
  29. pmc UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice
    Sihem Boudina
    Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diabetes 61:3260-9. 2012
    These studies investigate the role of uncoupling protein 3 (UCP3) in cardiac energy metabolism, cardiac O(2) consumption (MVO(2)), cardiac efficiency (CE), and mitochondrial uncoupling in high fat (HF)-fed or leptin-deficient mice...
  30. doi Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure
    Miranda Nabben
    Departments of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands
    FEBS Lett 585:4010-7. 2011
    Uncoupling protein 3 (UCP3) may reduce mitochondrial ROS production, and thereby protect against mitochondrial dysfunction in skeletal muscle. UCP3 has been suggested to specifically fulfill this role under high-fat conditions...
  31. pmc Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart
    Michael Huntgeburth
    Klinik III fur Innere Medizin, Herzzentrum der Universität zu Köln, Cologne, Germany
    PLoS ONE 6:e26628. 2011
    ..We aimed to characterize the functional network involving TGF-β₁, the renin-angiotensin system, and the β-adrenergic system in the heart...
  32. doi Muscle unloading-induced metabolic remodeling is associated with acute alterations in PPARdelta and UCP-3 expression
    Dawn J Mazzatti
    Unilever Corporate Research, Colworth Park, Sharnbrook, Bedfordshire, United Kingdom
    Physiol Genomics 34:149-61. 2008
    ....
  33. ncbi Expression of uncoupling protein 3 and GLUT4 gene in skeletal muscle of preterm newborns: possible control by AMP-activated protein kinase
    Petr Brauner
    Institute of Physiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic
    Pediatr Res 60:569-75. 2006
    ..Pediatr Res 53: 691-697, 2003)] suggested impaired postnatal recruitment of the gene for mitochondrial uncoupling protein 3 (UCP3) by nutritional lipids in skeletal muscle of neonates delivered before approximately 26 wk of ..
  34. pmc Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria
    Nadeene Parker
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 0XY, UK
    Biochem J 412:131-9. 2008
    ..specific for the adenine nucleotide translocase) was examined in skeletal muscle mitochondria from wild-type and Ucp3-knockout mice...
  35. doi Effects of UCP3 genotype, temperature and muscle type on energy turnover of resting mouse skeletal muscle
    C J Barclay
    Molecular Medicine, National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK
    Pflugers Arch 457:857-64. 2009
    Uncoupling protein 3 (UCP3) is a mitochondrial transporter protein which, when over-expressed in mice, is associated with increased metabolic rate, increased feeding and low body weight...
  36. doi Long-term high-fat feeding induces greater fat storage in mice lacking UCP3
    Sheila R Costford
    Faculty of Medicine, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Am J Physiol Endocrinol Metab 295:E1018-24. 2008
    Uncoupling protein-3 (UCP3) is a mitochondrial inner-membrane protein highly expressed in skeletal muscle...
  37. doi Characterization of survival and phenotype throughout the life span in UCP2/UCP3 genetically altered mice
    Roger B McDonald
    Department of Nutrition, One Shields Avenue, University of California, Davis, CA 95616, USA
    Exp Gerontol 43:1061-8. 2008
    ..Positive-TG), their non-overexpressing littermates (Negative-TG), mice that do not expression UCP2 (UCP2KO) or UCP3 (UCP3KO), and wild-type C57BL/6J mice (WT-Control)...
  38. doi UCP3 overexpression neutralizes oxidative stress rather than nitrosative stress in mouse myotubes
    Esther Barreiro
    Muscle and Respiratory System Research Unit Pneumology Department, IMIM Hospital del Mar, Centro de Investigación en Red de Enfermedades Respiratorias CibeRes, CEXS, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Barcelona, Spain
    FEBS Lett 583:350-6. 2009
    The deleterious effects of oxidants on proteins may be modified by overexpression of uncoupling protein 3 (UCP3) in skeletal muscle cells exposed to hyperoxia or H(2)O(2)...
  39. pmc Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins
    Kari E Wong
    Department of Medicine, Committee on Molecular Metabolism and Nutrition, The University of Chicago, MC 4076, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 296:E820-8. 2009
    ..beta-oxidation in the white adipose tissue was higher, and the expression of uncoupling protein (UCP) 1, UCP2 and UCP3 was markedly upregulated in VDR-null mice, suggesting a higher energy expenditure in the mutant mice...
  40. doi Uncoupling protein-3 as a molecular determinant of the action of 3,5,3'-triiodothyronine on energy metabolism
    Pierre Flandin
    Department of Cell Physiology and Metabolism, Medical University Centre, Geneva, Switzerland
    Endocrine 36:246-54. 2009
    ..To test the possibility that T3 might act via muscle uncoupling protein-3 (UCP3), an UCP3 knockout (KO) model was used...
  41. pmc Rapid turnover of mitochondrial uncoupling protein 3
    Vian Azzu
    Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Biochem J 426:13-7. 2010
    b>UCP3 (uncoupling protein 3) and its homologues UCP2 and UCP1 are regulators of mitochondrial function. UCP2 is known to have a short half-life of approx...
  42. doi Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARalpha and uncoupling protein in diet-induced obese mice
    Junko Nishimura
    Department of Internal Medicine, Oita University, Yufu Hasama, Oita, 879 5593 Japan
    J Nutr 140:496-500. 2010
    ..hepatic levels of protein CD36/fatty acid translocase, PPARalpha, and uncoupling protein (UCP) 2 and the levels of UCP3 in skeletal muscle were all greater in the Ile group than in the control mice (P < 0.05)...
  43. doi Absence of uncoupling protein-3 leads to greater activation of an adenine nucleotide translocase-mediated proton conductance in skeletal muscle mitochondria from calorie restricted mice
    Lisa Bevilacqua
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada KIH 8M5
    Biochim Biophys Acta 1797:1389-97. 2010
    ..by decreased mitochondrial reactive oxygen species generation and increased uncoupling protein-3 protein (UCP3) expression...
  44. doi Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects
    Irina G Shabalina
    The Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1797:968-80. 2010
    ..The content of UCP3 was increased 3-4 fold, but despite this, endogenous superoxide could not invoke a higher proton leak, and the ..
  45. pmc A novel intronic peroxisome proliferator-activated receptor gamma enhancer in the uncoupling protein (UCP) 3 gene as a regulator of both UCP2 and -3 expression in adipocytes
    Anne Bugge
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    J Biol Chem 285:17310-7. 2010
    ..UCP2 is ubiquitously expressed, while UCP3 is found primarily in muscles and adipose tissue...
  46. pmc The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
    Na Zhang
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 11:364-78. 2010
    ..These results demonstrate that FIH acts to a significant degree through the nervous system to regulate metabolism...
  47. pmc Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria
    Laurence J Toime
    Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK
    Free Radic Biol Med 49:606-11. 2010
    ..The uncoupling proteins (UCP1, UCP2, and UCP3) and adenine nucleotide translocase induce proton leak in response to exogenously added fatty acids, superoxide, or ..
  48. doi Acute starvation in C57BL/6J mice increases myocardial UCP2 and UCP3 protein expression levels and decreases mitochondrial bio-energetic function
    Chun Ming Wang
    Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Stress 14:66-72. 2011
    ..05). These bio-energetic functional changes were associated with increases in mitochondrial UCP2 and UCP3 protein expression...
  49. pmc Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3
    Ryan J Mailloux
    Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada, K1H 8M5
    J Biol Chem 286:21865-75. 2011
    ..However, the molecular control mechanism(s) governing these proteins remains elusive. Here we reveal that UCP2 and UCP3 contain reactive cysteine residues that can be conjugated to glutathione...
  50. doi Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice
    Miranda Nabben
    Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, The Netherlands
    Biochim Biophys Acta 1807:1095-105. 2011
    The function of uncoupling protein 3 (UCP3) is still not established. Mitochondrial uncoupling, control of ROS production, protection against lipotoxicity and protection against oxidative stress are functions classically discussed...
  51. doi Absence of mitochondrial uncoupling protein 3: effect on thymus and spleen in the fed and fasted mice
    Orlagh M Kelly
    School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    Biochim Biophys Acta 1807:1064-74. 2011
    b>Mitochondrial uncoupling protein 3 (UCP3) is constitutively expressed in mitochondria from thymus and spleen of mice, and confocal microscopy has been used to visualize UCP3 in situ in mouse thymocytes...
  52. ncbi Activators of peroxisome proliferator-activated receptor-alpha induce the expression of the uncoupling protein-3 gene in skeletal muscle: a potential mechanism for the lipid intake-dependent activation of uncoupling protein-3 gene expression at birth
    S Brun
    Department of Biochemistry and Molecular Biology, University of Barcelona, Spain
    Diabetes 48:1217-22. 1999
    ..It is proposed that the UCP-3 gene is predominantly regulated in neonatal muscle by PPAR-alpha activation...
  53. pmc Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3
    Martin D Brand
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, U K
    Biochem J 368:597-603. 2002
    ..muscle mitochondria isolated from mice genetically engineered to underexpress or overexpress uncoupling protein 3 (UCP3)...
  54. ncbi Identification of seven loci for static glucokinesis and dynamic glucokinesis in mice
    Sei Komatsu
    Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center GSC, RIKEN Yokohama Institute, Suehirocho, Tsurumi ku, Kanagawa, Japan
    Mamm Genome 13:293-8. 2002
    ..Bwt1k was linked to obesity. Thus, the genetic factors for static glucokinesis and those for dynamic glucokinesis partially overlapped...
  55. pmc Excess recovery heat production by isolated muscles from mice overexpressing uncoupling protein-3
    N A Curtin
    Biological Structure and Function Section, Division of Biomedical Sciences, Faculty of Medicine, Sir Alexander Fleming Building, Imperial College, London SW7 2AZ, UK
    J Physiol 542:231-5. 2002
    ..729 +/- 0.072 relative units. The extra recovery heat represents inefficient recovery in UCP-3tg fibres. This is the first direct evidence of enhanced energy dissipation as heat when UCP-3tg is overexpressed...
  56. ncbi Understanding adipose tissue development from transgenic animal models
    Philippe Valet
    INSERM Unit 317, Louis Bugnard Institute, Paul Sabatier University, Bldg L3, Rangueil University Hospital, 31403 Toulouse Cedex 4, France
    J Lipid Res 43:835-60. 2002
    ..However, lack of phenotypes also illustrates the capacity of animals to set up adaptive mechanisms...
  57. ncbi The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3
    Susana Cadenas
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, United Kingdom
    J Biol Chem 277:2773-8. 2002
    The ability of native uncoupling protein-3 (UCP3) to uncouple mitochondrial oxidative phosphorylation is controversial...
  58. ncbi Mitochondrial efficiency: lessons learned from transgenic mice
    M E Harper
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ont, Canada K1H 8M5
    Biochim Biophys Acta 1504:159-72. 2001
    ..Many studies have also shown that genetic background can affect phenotypic outcomes, and that the upregulated expression of genes that are related to the modified gene often complicates the interpretation of findings...
  59. ncbi First evidence of uncoupling protein-2 (UCP-2) and -3 (UCP-3) gene expression in piglet skeletal muscle and adipose tissue
    M Damon
    INRA, Station de Recherches Porcines, 35590, Saint Gilles, France
    Gene 246:133-41. 2000
    ..In the light of the improving knowledge on the UCPs family, we decided to examine both UCP2 and UCP3 mRNA expression in piglet skeletal muscle and adipose tissue...
  60. ncbi Characterization and chromosomal mapping of a mouse ortholog of the late-infantile ceroid-lipofuscinosis gene CLN2
    M L Katz
    Mason Eye Institute, University of Missouri School of Medicine, One Hospital Drive, Columbia, Missouri 65212, USA
    Mamm Genome 10:1050-3. 1999
    ..Characterization of the mouse Cln2 gene will facilitate generation of a mouse model for late-infantile ceroid-lipofuscinosis by gene targeting and identification of functionally important regions of the Cln2 protein...
  61. ncbi Uncoupling protein-3 (UCP3) mRNA expression in reconstituted human muscle after myoblast transplantation in RAG2-/-/gamma c/C5(-) immunodeficient mice
    Nolwen Guigal
    Institut de Recherches Servier, Division de Pharmacologie Moleculaire et Cellulaire, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    J Biol Chem 277:47407-11. 2002
    Uncoupling protein-3 (UCP3), which is expressed abundantly in skeletal muscle, is one of the carrier proteins dissipating the transmitochondrial electrochemical gradient as heat and has therefore been implicated in the regulation of ..
  62. ncbi Overexpression of GLUT4 in mice causes up-regulation of UCP3 mRNA in skeletal muscle
    N Tsuboyama-Kasaoka
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo, 162 8636, Japan
    Biochem Biophys Res Commun 258:187-93. 1999
    b>Mitochondrial uncoupling protein 3 (UCP3) is expressed in skeletal muscles. We have hypothesized that increased glucose flux in skeletal muscles may lead to increased UCP3 expression...
  63. ncbi Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes
    D W Gong
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland, 20892 1770, USA
    Biochem Biophys Res Commun 256:27-32. 1999
    Uncoupling protein-1 (UCP1) dissipates the transmitochondrial proton gradient as heat. UCP2 and UCP3 are two recently discovered homologues that also have uncoupling activity and thus presumably have a role in energy homeostasis...
  64. ncbi In the rat, tumor necrosis factor alpha administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: a possible mechanism for cytokine-induced thermogenesis?
    S Busquets
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Spain
    FEBS Lett 440:348-50. 1998
    Since the discovery of the new members of the UCP (uncoupling protein) family, UCP2 and UCP3, very few studies have dealt with the regulation of their expression...
  65. ncbi Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map
    H Yoshitomi
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Gene 215:77-84. 1998
    ..Recently, the third UCP homologue was discovered in humans, which was designated as UCP3. We now report molecular cloning of full-length mouse UCP3 cDNA and its 5'-flanking genomic region...
  66. ncbi Up-regulation of uncoupling protein 3 (UCP3) mRNA by exercise training and down-regulation of UCP3 by denervation in skeletal muscles
    N Tsuboyama-Kasaoka
    Division of Clinical Nutrition, National Institute of Health and Nutrition, 1 23 1 Toyama, Tokyo, Shinjuku ku, 162 8636, Japan
    Biochem Biophys Res Commun 247:498-503. 1998
    ..b>UCP3, mitochondrial uncoupling protein, is expressed in skeletal muscles...
  67. ncbi Transcriptional regulation of muscle-specific genes during myoblast differentiation
    T Shimokawa
    Molecular Medicine Laboratories, Yamanouchi Pharmaceutical Co, Ltd, Ibaraki, Japan
    Biochem Biophys Res Commun 246:287-92. 1998
    ..Muscle-specific uncoupling protein UCP3 mRNA was detected during differentiation and increased rapidly within 8 days...
  68. ncbi High expression of uncoupling protein 2 in foetal liver
    Z Hodny
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    FEBS Lett 425:185-90. 1998
    ..Neither UCP1 nor UCP3 mRNA was expressed in foetal liver...
  69. ncbi Uncoupling protein-3: a muscle-specific gene upregulated by leptin in ob/ob mice
    Q Liu
    Department of Human Genetics, Merck Research Laboratories, West Point, PA 19486, USA
    Gene 207:1-7. 1998
    We identified and partially characterized another member of the uncoupling protein termed UCP3. Human and mouse UCP3 protein sequences are 86% identical to each other, and 73% and 59% identical to UCP2 and UCP1, respectively...
  70. ncbi SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription
    Ramon Amat
    Departament de Bioquimica i Biologia Molecular and Institut de Biomedicina, Universitat de Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Instituto de Salud Carlos III, Avda Diagonal 645, 08028 Barcelona, Spain
    J Biol Chem 282:34066-76. 2007
    b>UCP3 (uncoupling protein-3) is a mitochondrial membrane transporter expressed preferentially in skeletal muscle...
  71. ncbi Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle
    C Son
    Department of Medicine and Clinical Science, Endocrinology and Metabolism, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Diabetologia 47:47-54. 2004
    It has been suggested that uncoupling protein 3 (UCP3) can increase energy expenditure, thereby regulating body weight...
  72. pmc Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance
    Cheol Soo Choi
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 9812, USA
    J Clin Invest 117:1995-2003. 2007
    ..Uncoupling protein 3 (UCP3) has been postulated to dissipate the mitochondrial proton gradient and cause metabolic inefficiency...
  73. ncbi Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3
    Seung Hun Cha
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 317:301-8. 2004
    ....
  74. ncbi Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice
    Keiko Higuchi
    Department of Anatomy, Biology, and Medicine, Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idai ga oka, Hasama cho, Yufu City, Oita 879 5593, Japan
    Endocrinology 148:2690-7. 2007
    ..increased mRNA expression of UCP1, a marker of peripheral energy expenditure, in brown adipose tissue (BAT) and of UCP3, a regulator of fatty acid export, in skeletal muscle...
  75. ncbi Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression
    Neus Pedraza
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
    Endocrinology 147:4695-704. 2006
    Uncoupling protein-3 (UCP3) is a member of the mitochondrial carrier family expressed preferentially in skeletal muscle and heart...
  76. ncbi The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice
    Joris Hoeks
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    FEBS Lett 580:1371-5. 2006
    Uncoupling protein-3 (UCP3) has been suggested to protect against lipid-induced oxidative damage...
  77. ncbi Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation
    V Bezaire
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    FASEB J 19:977-9. 2005
    Uncoupling protein 3 (UCP3) expression is directly correlated to fatty acid oxidation in skeletal muscle. UCP3 has been hypothesized to facilitate high rates of fatty acid oxidation, but evidence thus far is lacking...
  78. ncbi A paternally imprinted QTL for mature body mass on mouse chromosome 8
    Kellie A Rance
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, UK
    Mamm Genome 16:567-77. 2005
    ....
  79. ncbi Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels
    Andrew J Murray
    University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
    Diabetes 54:3496-502. 2005
    ..Cardiac UCP2 and UCP3 were significantly lower in the PPARalpha-/- mouse than in the wild type...
  80. ncbi Hyperoxia-mediated oxidative stress increases expression of UCP3 mRNA and protein in skeletal muscle
    Pierre Flandin
    Department of Cell Physiology and Metabolism, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    FEBS Lett 579:3411-5. 2005
    The uncoupling protein-3 (UCP3) is a mitochondrial protein expressed mainly in skeletal muscle. Among several hypotheses for its physiological function, UCP3 has been proposed to prevent excessive production of reactive oxygen species...
  81. pmc Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy
    Hitoshi Watanabe
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Physiol 216:419-25. 2008
    ..We showed for the first time that epiphyseal chondrocytes expressed UCP3. In hypoxia, UCP3 mediated regulation of the mitochondrial transmembrane potential (DeltaPsi(m)) was dependent on ..
  82. ncbi Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice
    Sheila R Costford
    Dept of Biochemistry, Microbiology and Immunology, Faculty of Medicine, Univ of Ottawa, 451 Smyth Rd, Ottawa, ON, Canada K1H 8M5
    Am J Physiol Endocrinol Metab 290:E1304-12. 2006
    Uncoupling protein-3 (UCP3) is a poorly understood mitochondrial inner membrane protein expressed predominantly in skeletal muscle...
  83. ncbi Overexpression of UCP3 in both murine and human myotubes is linked with the activation of proteolytic systems: a role in muscle wasting?
    Silvia Busquets
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain
    Biochim Biophys Acta 1760:253-8. 2006
    Overexpression of the UCP3 gene in both murine and human myotube cell cultures leads to a significant activation of the different proteolytic systems involved in muscle myofibrillar protein breakdown...
  84. pmc Differential regulation of expression of genes encoding uncoupling proteins 2 and 3 in brown adipose tissue during lactation in mice
    N Pedraza
    Department of Biochemistry and Molecular Biology, University of Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain
    Biochem J 355:105-11. 2001
    ..Our studies show that UCP2 mRNA expression does not change during the breeding cycle in mice. In contrast, UCP3 mRNA is down-regulated in lactation but it recovers after weaning, in parallel with UCP1 mRNA...
  85. ncbi Overexpression of UCP-3 in skeletal muscle of mice results in increased expression of mitochondrial thioesterase mRNA
    G B Moore
    Department of Vascular Biology, GlaxoSmithKline, Harlow, Essex, United Kingdom
    Biochem Biophys Res Commun 283:785-90. 2001
    ..The large increase in MTE-1 both confirms the importance of this gene in situations where mitochondrial beta-oxidation is increased and supports the hypothesis that UCP-3 exports fatty acids generated by MTE-1 in the mitochondrion...
  86. ncbi Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principal component analysis
    Akira Ishikawa
    Laboratory of Animal Genetics, Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan
    Genes Genet Syst 79:27-39. 2004
    ..These results suggest that the identified 13 QTLs, most of which affected the entire growth process, are very important contributors to complex genetic networks of postnatal growth...
  87. ncbi Differential regulation of the promoter activity of the mouse UCP2 and UCP3 genes by MyoD and myogenin
    Dongho Kim
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    J Biochem Mol Biol 40:921-7. 2007
    UCP2 and UCP3 are members of the uncoupling protein family, which may play roles in energy homeostasis...
  88. ncbi Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance
    Katrine Almind
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:1535-43. 2003
    ....
  89. ncbi Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1
    O Boss
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Biochem Biophys Res Commun 261:870-6. 1999
    ..e., mitochondrial uncoupling proteins UCP2 and UCP3, and peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1), in mouse skeletal muscle...
  90. ncbi Pharmacology: uncoupling the agony from ecstasy
    Edward M Mills
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 426:403-4. 2003
    ..Our findings indicate that UCP-3 is important in MDMA-induced hyperthermia and point to a new therapeutic direction for solving an increasing public-health problem...
  91. pmc Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region
    Gemma Solanes
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, E 08028 Barcelona, Spain
    Biochem J 386:505-13. 2005
    The transcription of the human UCP3 (uncoupling protein-3) gene in skeletal muscle is tightly regulated by metabolic signals related to fatty acid availability...