Ucp1

Summary

Gene Symbol: Ucp1
Description: uncoupling protein 1 (mitochondrial, proton carrier)
Alias: AI385626, Slc25a7, Ucp, mitochondrial brown fat uncoupling protein 1, UCP 1, solute carrier family 25 member 7, thermogenin, uncoupling protein 1, mitochondrial, uncoupling protein, mitochondrial
Species: mouse

Top Publications

  1. ncbi Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis
    Marcelo A Christoffolete
    Department of Medicine, Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 53:577-84. 2004
  2. pmc Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype
    Haibo Wang
    The Hamner Institutes for Health Sciences, 6 Davis Drive, P O Box 12137, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 28:2187-200. 2008
  3. doi Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes
    Masaaki Muraoka
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, 7 6 8, Asagi, Saito, Ibaraki, Osaka 567 0085, Japan
    Am J Physiol Endocrinol Metab 296:E1430-9. 2009
  4. ncbi Identification of a functioning mitochondrial uncoupling protein 1 in thymus
    Audrey M Carroll
    Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 280:15534-43. 2005
  5. ncbi Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress
    Jozef Ukropec
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, 70808, USA
    Endocrinology 147:2468-80. 2006
  6. pmc Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha
    Darja Debevec
    Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, United Kingdom
    Mol Endocrinol 21:1581-92. 2007
  7. pmc Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue
    Carmen J Narvaez
    GenNYsis Center for Excellence in Cancer Genomics, 122G Cancer Research Center, University at Albany, Rensselaer, NY 12144, USA
    Endocrinology 150:651-61. 2009
  8. pmc An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene
    U C Kozak
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mol Cell Biol 14:59-67. 1994
  9. pmc Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    J Kopecky
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Clin Invest 96:2914-23. 1995
  10. ncbi Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
    S Enerback
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nature 387:90-4. 1997

Research Grants

Scientific Experts

Detail Information

Publications145 found, 100 shown here

  1. ncbi Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis
    Marcelo A Christoffolete
    Department of Medicine, Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 53:577-84. 2004
    ..The latter is the preponderant determinant of the impaired adaptive thermogenesis and hypothermia in cold-exposed Dio2(-/-) mice...
  2. pmc Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype
    Haibo Wang
    The Hamner Institutes for Health Sciences, 6 Davis Drive, P O Box 12137, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 28:2187-200. 2008
    ..tissue is a major site of energy dissipation through adaptive thermogenesis mediated by uncoupling protein 1 (UCP1) in mammals...
  3. doi Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes
    Masaaki Muraoka
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, 7 6 8, Asagi, Saito, Ibaraki, Osaka 567 0085, Japan
    Am J Physiol Endocrinol Metab 296:E1430-9. 2009
    ..the levels of peroxisome proliferator-activated receptor-coactivator-1alpha (PGC-1alpha) and uncoupling protein-1 (UCP-1) mRNA were increased, and the induction was inhibited by overexpression of SIK2 (S587A) mutant or dominant-..
  4. ncbi Identification of a functioning mitochondrial uncoupling protein 1 in thymus
    Audrey M Carroll
    Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland
    J Biol Chem 280:15534-43. 2005
    We present evidence that rat and mouse thymi contain mitochondrial uncoupling protein (UCP 1). Reverse transcriptase-PCR detected RNA transcripts for UCP 1 in whole thymus and in thymocytes...
  5. ncbi Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress
    Jozef Ukropec
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, 70808, USA
    Endocrinology 147:2468-80. 2006
    ..b>Ucp1(-/-) mice...
  6. pmc Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha
    Darja Debevec
    Institute of Reproductive and Developmental Biology, Imperial College London, London W12 0NN, United Kingdom
    Mol Endocrinol 21:1581-92. 2007
    Expression of uncoupling protein 1 (Ucp1) mRNA is elevated in differentiated adipocytes derived from brown or white adipose tissue devoid of the nuclear receptor corepressor receptor interacting protein 140 (RIP140)...
  7. pmc Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue
    Carmen J Narvaez
    GenNYsis Center for Excellence in Cancer Genomics, 122G Cancer Research Center, University at Albany, Rensselaer, NY 12144, USA
    Endocrinology 150:651-61. 2009
    ..Collectively, these studies identify a novel role for 1,25-dihydroxyvitamin D(3) and the VDR in the control of adipocyte metabolism and lipid storage in vivo...
  8. pmc An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene
    U C Kozak
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mol Cell Biol 14:59-67. 1994
    Previous studies on the regulation of a Ucp minigene in transgenic mice demonstrated that the sequences necessary for brown-fat-specific expression and inducibility by norepinephrine were located in the 5' flanking region between 1 and 2...
  9. pmc Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    J Kopecky
    Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Clin Invest 96:2914-23. 1995
    The brown fat-specific mitochondrial uncoupling protein (UCP) provides a mechanism for generating heat by uncoupling respiration and oxidative phosphorylation...
  10. ncbi Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
    S Enerback
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Nature 387:90-4. 1997
    The mitochondrial uncoupling protein (UCP) in the mitochondrial inner membrane of mammalian brown adipose tissue generates heat by uncoupling oxidative phosphorylation. This process protects against cold and regulates energy balance...
  11. pmc Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene
    T Tanaka
    Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663, Japan
    EMBO J 16:7432-43. 1997
    ....
  12. ncbi Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    B Li
    Departments of Medicine and Cell Biology and Physiology, Division of Atherosclerosis, Nutrition, and Lipid Research, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Med 6:1115-20. 2000
    ..for obesity and type 2 diabetes, we generated transgenic mice expressing the mitochondrial uncoupling protein (Ucp) in skeletal muscle...
  13. ncbi UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency
    J Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1504:82-106. 2001
    The uniqueness of UCP1 (as compared to UCP2/UCP3) is evident from expression analysis and ablation studies...
  14. ncbi Superoxide activates mitochondrial uncoupling proteins
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Nature 415:96-9. 2002
    Uncoupling protein 1 (UCP1) diverts energy from ATP synthesis to thermogenesis in the mitochondria of brown adipose tissue by catalysing a regulated leak of protons across the inner membrane...
  15. pmc A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling
    Karim S Echtay
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    EMBO J 22:4103-10. 2003
    ..trans-retinal and other 2-alkenals) specifically induce uncoupling of mitochondria through the uncoupling proteins UCP1, UCP2 and UCP3 and the adenine nucleotide translocase (ANT)...
  16. ncbi UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction
    Dong Ho Han
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 286:E347-53. 2004
    ..in insulin resistance, we studied mice with high-level expression of uncoupling protein-1 in skeletal muscle (UCP-H mice)...
  17. ncbi Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation
    Susanne Klaus
    German Institute of Human Nutrition Potsdam Rehbruecke, Group of Energy Metabolism, Nuthetal, Germany
    Physiol Genomics 21:193-200. 2005
    Skeletal muscle uncoupling by ectopic expression of mitochondrial uncoupling protein 1 (UCP1) has been shown to result in a lean phenotype in mice characterized by increased energy expenditure (EE), resistance to diet-induced obesity, and ..
  18. ncbi Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation
    Ken ichi Inokuma
    Dept of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Am J Physiol Endocrinol Metab 290:E1014-21. 2006
    Mitochondrial uncoupling protein-1 (UCP1) has been thought to be a key molecule for thermogenesis during cold exposure and spontaneous hyperphagia and thereby in the autonomic regulation of energy expenditure and adiposity...
  19. pmc Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria
    Telma C Esteves
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 395:619-28. 2006
    The kinetics of proton transport through mammalian UCP1 (uncoupling protein 1) expressed in yeast mitochondria were measured. There was little or no UCP1 activity in the absence of added palmitate, but significant activity in its presence...
  20. ncbi UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent
    Irina G Shabalina
    Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 281:13882-93. 2006
    ..We have investigated here the ability of HNE to activate UCP1. Using brown fat mitochondria from UCP1+/+ and UCP1-/- mice to allow for identification of UCP1-dependent effects, ..
  21. pmc Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
    Katrine Almind
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:2366-71. 2007
    ..At a molecular level, this difference correlates with a marked higher expression of uncoupling protein 1 (UCP1) and a higher degree of uncoupling in vitro in mitochondria isolated from muscle of 129 versus B6 mice...
  22. pmc RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes
    Evangelos Kiskinis
    Molecular Endocrinology Laboratory, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK
    EMBO J 26:4831-40. 2007
    ..Here we show by analysis of Ucp1, a gene which is typically expressed in brown but not white adipocytes, that RIP140 is essential for both DNA and ..
  23. doi Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo
    Susanne Neschen
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Physiol Genomics 33:333-40. 2008
    ..b>UCP1-mediated uncoupling of oxidative phosphorylation in skeletal muscle was paralleled by AMPK activation and thereby ..
  24. pmc PRDM16 controls a brown fat/skeletal muscle switch
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nature 454:961-7. 2008
    ..Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis...
  25. pmc New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    Yu Hua Tseng
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 454:1000-4. 2008
    ..5), increased expression of the brown-fat-defining marker uncoupling protein 1 (UCP1) and adipogenic transcription factors PPARgamma and CCAAT/enhancer-binding proteins (C/EBPs), and induction of ..
  26. doi Hypoxia-independent angiogenesis in adipose tissues during cold acclimation
    Yuan Xue
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Cell Metab 9:99-109. 2009
    ..exposure resulted in elevated expression levels of brown-fat-associated proteins, including uncoupling protein-1 (UCP1) and PGC-1alpha...
  27. doi UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    Helena M Feldmann
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Cell Metab 9:203-9. 2009
    As original studies of UCP1-ablated mice failed to demonstrate an obesogenic effect, alternative mechanisms for adaptive adrenergic thermogenesis have been sought...
  28. pmc Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting
    Simao Teixeira da Rocha
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 5:e1000392. 2009
    ..We propose a negative correlation between gene dosage and survival that fixes an upper limit on growth promotion by Dlk1, and we hypothesize that trade-off between growth and lethality might have driven imprinting at this locus...
  29. pmc Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons
    Luc Dupuis
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, France
    PLoS ONE 4:e5390. 2009
    ..It remains unknown whether muscle abnormalities in energy metabolism are causally involved in the destruction of neuromuscular junction (NMJ) and subsequent motor neuron degeneration during ALS...
  30. pmc Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex
    Shingo Kajimura
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 460:1154-8. 2009
    ..These data indicate that the PRDM16-C/EBP-beta complex initiates brown fat formation from myoblastic precursors, and may provide opportunities for the development of new therapeutics for obesity and type-2 diabetes...
  31. doi UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production
    Susanne Keipert
    German Institute of Human Nutrition, Group of Energy Metabolism, 14558 Nuthetal, Germany
    Biochim Biophys Acta 1797:324-30. 2010
    ..physiological effects could be demonstrated in several mouse models ectopically expressing uncoupling protein 1 (UCP1)...
  32. pmc Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocyt
    Natasa Petrovic
    Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 285:7153-64. 2010
    ..are distinct from white adipocytes has spurred questions concerning the origin and molecular characteristics of the UCP1-expressing cells observed in classic white adipose tissue depots under certain physiological or pharmacological ..
  33. doi Possible involvement of uncoupling protein 1 in appetite control by leptin
    Yuko Okamatsu-Ogura
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Exp Biol Med (Maywood) 236:1274-81. 2011
    ..To clarify whether UCP1 is also involved in the anorexigenic effect of leptin, in this study we examined the effect of leptin on food ..
  34. pmc PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue
    Stine Ringholm
    Department of Biology, Centre of Inflammation and Metabolism and August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e64123. 2013
    The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT, 3) ..
  35. doi FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes
    D Tews
    Division of Pediatric Endocrinology and Diabetes, University Medical Center Ulm, Eythstrasse 24, 89075 Ulm, Germany
    Endocrinology 154:3141-51. 2013
    ..Uncoupling protein 1 (Ucp-1) was significantly higher expressed in both gonadal and inguinal adipose depots of Fto(-/-) compared with Fto(+/+)..
  36. ncbi High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content
    Elodie Couplan
    Ceremod CNRS UPR9078, 9 rue Jules Hetzel, 92190 Meudon, France
    J Biol Chem 277:43079-88. 2002
    The mitochondrial uncoupling protein of brown adipose tissue (UCP1) was expressed in skeletal muscle and heart of transgenic mice at levels comparable with the amount found in brown adipose tissue mitochondria...
  37. ncbi Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes
    Angela M Valverde
    Departamento de Bioquimica y Biologia Molecular, Centro Mixto Consejo Superior de Investigaciones Cientificas Universidad Complutense de Madrid, Facultad de Farmacia, Universidad Complutense, Spain
    J Biol Chem 278:10221-31. 2003
    ..Treatment of wild-type brown adipocytes with insulin for 24 h up-regulated uncoupling protein-1 (UCP-1) expression and transactivated the UCP-1 promoter; this effect was abolished in the absence of IRS-1 or in the ..
  38. ncbi Uncoupling protein 2, but not uncoupling protein 1, is expressed in the female mouse reproductive tract
    Sophie Rousset
    CNRS, Unité Propre de Recherche 9078, Faculte de Medecine Necker Enfants Malades, 156 rue de Vaugirard, 75730 Paris Cedex 15, France
    J Biol Chem 278:45843-7. 2003
    Uncoupling proteins (UCPs) are transporters of the inner mitochondrial membrane. Whereas UCP1 is uniquely present in brown adipose tissue where it uncouples respiration from ATP synthesis and activates respiration and heat production, ..
  39. pmc Phytanic acid, a novel activator of uncoupling protein-1 gene transcription and brown adipocyte differentiation
    Agatha Schluter
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Facultat de Biologia, Avda Diagonal 645, Barcelona 08028, Spain
    Biochem J 362:61-9. 2002
    ..Phytanic acid increased uncoupling protein-1 (UCP1) mRNA expression in brown adipocytes differentiated in culture...
  40. pmc p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    Wenhong Cao
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3057-67. 2004
    ..fat requires beta-adrenergic elevations in cyclic AMP (cAMP) to increase expression of the uncoupling protein 1 (UCP1) gene...
  41. ncbi Adiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos
    Noritaka Fujimoto
    Department of Anatomy, Biology and Medicine, Oita University, Faculty of Medicine, 1 1 Hasama machi, Oita 879 5593, Japan
    Biochim Biophys Acta 1731:1-12. 2005
    ..These data indicate that adiponectin has important roles in glucose and lipid metabolism during the perinatal period...
  42. ncbi Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue
    Adriana Voss-Andreae
    Center for the Study of Weight Regulation and Associated Disorders and Vollum Institute, Oregon Health and Sciences University, Portland, Oregon 97239 3098, and Division of Endocrinology, Rhode Island Hospital, Providence 02903, USA
    Endocrinology 148:1550-60. 2007
    ..Our results provide a neuroanatomic substrate for MC4R regulating sympathetically mediated IBAT thermogenesis and demonstrate that the MC4R is critically required for acute high-fat- and cold-induced IBAT thermogenesis...
  43. pmc CARM1 promotes adipocyte differentiation by coactivating PPARgamma
    Neelu Yadav
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park, Smithville, Texas 78957, USA
    EMBO Rep 9:193-8. 2008
    ..Together, these results show that CARM1 promotes adipocyte differentiation by coactivating PPARgamma-mediated transcription and thus might be important in energy balance...
  44. pmc Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
    Ying Cheng
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 59:17-25. 2010
    ..The cellular mechanisms responsible for this loss, however, are unclear. The goal of current study is to investigate possible mechanisms...
  45. pmc Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue
    A Shore
    Division of Biomedical Science, Imperial College, Wye Campus, Ashford, Kent, UK
    Diabetologia 53:1164-73. 2010
    Increasing the expression of the brown adipose tissue-specific gene uncoupling protein-1 (Ucp1) is a potential target for treating obesity...
  46. doi Effect of epinephrine deficiency on cold tolerance and on brown adipose tissue
    Rana I Sharara-Chami
    Division of Critical Care Medicine, Department of Anesthesiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, United States
    Mol Cell Endocrinol 328:34-9. 2010
    ..Although temperature was normal in Pnmt(-/-) mice, the brown fat response to cold was abnormal with no increase in Ucp-1 or Pgc-1alpha mRNA levels (but with an exaggerated cold-induced lipid loss from the tissue)...
  47. doi Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak
    Martin Jastroch
    Institute for Diabetes and Obesity, Helmholtz Zentrum Munich, Neuherberg, Germany
    Biochim Biophys Acta 1817:1660-70. 2012
    ..We here introduce a novel mammalian cell culture system (Human Embryonic Kidney 293 - HEK293) to study UCP1 function...
  48. doi ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes
    Karen Dixen
    Department of Biomedical Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Obesity (Silver Spring) 21:516-24. 2013
    ..Estrogen-related receptors (ERRs) are important regulators of energy metabolism. Here we investigated the hypothesis that ERRγ impacts on differentiation and function of brown adipocytes...
  49. pmc EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
    Haruya Ohno
    1 UCSF Diabetes Center, Department of Cell and Tissue Biology, University of California, San Francisco, 35 Medical Center Way, San Francisco, California 94143 0669, USA 2
    Nature 504:163-7. 2013
    ..These data indicate that EHMT1 is an essential enzymatic switch that controls brown adipose cell fate and energy homeostasis. ..
  50. doi Downregulation of uncoupling protein-1 mRNA expression and hypoadiponectinemia in a mouse model of sleep apnea
    Cintia Zappe Fiori
    Postgraduate Program in Cardiology, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brazil
    Sleep Breath 18:541-8. 2014
    ..The aim of the present study was to assess the effect of a sleep apnea model on a limited set of specific molecular, biochemical, histological, and behavioral parameters of adipose tissue function...
  51. pmc Brown adipose tissue dynamics in wild-type and UCP1-knockout mice: in vivo insights with magnetic resonance
    Kirsten Grimpo
    Faculty of Biology, Department of Animal Physiology, Philipps Universitat Marburg, 35043 Marburg, Germany
    J Lipid Res 55:398-409. 2014
    ..spectroscopy to compare interscapular brown adipose tissue (iBAT) of wild-type (WT) and uncoupling protein 1 (UCP1)-knockout mice lacking UCP1-mediated nonshivering thermogenesis (NST)...
  52. pmc Biphasic effect of melanocortin agonists on metabolic rate and body temperature
    Beth Lute
    Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA
    Cell Metab 20:333-45. 2014
    ..We propose that the hypometabolism/hypothermia is a regulated response, potentially beneficial during extreme physiologic stress. ..
  53. pmc Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes
    Yongguo Li
    Molecular Nutritional Medicine, Else Kroner Fresenius Center for Nutritional Medicine, Technische Universitat Munchen, Freising, Germany
    EMBO Rep 15:1069-76. 2014
    Thermogenesis in brown adipocytes, conferred by mitochondrial uncoupling protein 1 (UCP1), is receiving great attention because metabolically active brown adipose tissue may protect humans from metabolic diseases...
  54. pmc Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria
    Irina G Shabalina
    Department of Molecular Biosciences, The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91, Stockholm, Sweden
    Arch Toxicol 90:1117-28. 2016
    ..The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate...
  55. doi Sympathetic Nerve Activity Maintains an Anti-Inflammatory State in Adipose Tissue in Male Mice by Inhibiting TNF-α Gene Expression in Macrophages
    Lijun Tang
    Division of Endocrinology and Metabolism L T, S O, K T, T Sa, K S, S Y, Y M, Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan Department of Physiological Sciences S O, T Sa, Y M, Sokendai The Graduate University for Advanced Studies, Hayama, Kanagawa 240 0193, Japan Department of Integrative Physiology T Sh, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima City, Tokushima 770 8503, Japan and Section of Comparative Medicine C T, Yale University School of Medicine, New Haven, Connecticut 06520 8016
    Endocrinology 156:3680-94. 2015
    ....
  56. doi The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue
    Karolina E Hilse
    Institute of Physiology, Pathophysiology and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria
    Biochim Biophys Acta 1857:72-8. 2016
    b>UCP1 and UCP3 are members of the uncoupling protein (UCP) subfamily and are localized in the inner mitochondrial membrane...
  57. pmc IRE1α-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes
    Rie Asada
    Department of Biochemistry, Institute of Biomedical and Health Science, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8553, Japan
    Sci Rep 5:16580. 2015
    ..are able to dissipate energy in the form of heat owing to their mitochondrial protein, uncoupling protein 1 (UCP1)...
  58. doi FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
    Michelle M Kwon
    Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
    Cell Rep 13:1521-7. 2015
    ..FGF21)-mediated weight loss and improvements in glucose metabolism correlate with increased uncoupling protein 1 (Ucp1) levels in adipose tissues, suggesting that UCP1-dependent thermogenesis may drive FGF21 action...
  59. doi Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway
    Yannick Jeanson
    STROMAlab, Universite de Toulouse, CNRS, EFS, ENVT, INSERM, BP 84225, F 31 432 Toulouse Cedex 4, France
    Biochem J 473:685-92. 2016
    ....
  60. pmc Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2)
    Kevin Schneider
    From the Department of Laboratory Medicine and Pathology and
    J Biol Chem 291:7754-66. 2016
    ..These findings suggest that increasing oxidative stress by limitingNrf2function in white adipocytes may be a novel means to modulate energy balance as a treatment of obesity and related clinical disorders. ..
  61. doi Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 expression in mice
    Tomoya Sakamoto
    Kyoyo University
    Am J Physiol Endocrinol Metab . 2016
    ..Cold exposure significantly induced the expression levels of uncoupling protein-1 (UCP1), which is a mitochondrial protein unique in thermogenic adipocytes, in C57BL/6 mice fed a normal diet...
  62. ncbi Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo
    Martin Rossmeisl
    Department of Adipose Tissue Biology and Center for Integrated Genomics, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Eur J Biochem 269:19-28. 2002
    Mitochondrial uncoupling protein 1 (UCP1) is a specific marker of multilocular brown adipocytes...
  63. ncbi The role of uncoupling protein 1 in the metabolism and adiposity of RII beta-protein kinase A-deficient mice
    Michael A Nolan
    Department of Pharmacology, Box 357750, University of Washington, Seattle, Washington 98195 7750, USA
    Mol Endocrinol 18:2302-11. 2004
    ..oxygen consumption along with a 4-fold increase in the brown adipose-specific mitochondrial uncoupling protein 1 (UCP1)...
  64. ncbi Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue
    Ken ichi Inokuma
    Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Diabetes 54:1385-91. 2005
    ..To clarify the roles of the principal thermogenic molecule mitochondrial uncoupling protein 1 (UCP1) in the sympathetically stimulated glucose utilization, we investigated the uptake of 2-deoxyglucose (2-DG) into ..
  65. doi Uncoupling protein 1 expression and high-fat diets
    Tobias Fromme
    Else Kröner Fresenius Center, Technische Universitat Munchen, Freising, Germany
    Am J Physiol Regul Integr Comp Physiol 300:R1-8. 2011
    Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled nonshivering thermogenesis in brown adipocytes. This process combusts stored and nutrient energy as heat...
  66. doi Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression
    Maud Borensztein
    Genetics and Development Department, Institut National de Santé et de Recherche Médicale INSERM U567, Centre National de Recherche Scientifique CNRS Unité Mixte de Recherche 8104, University of Paris Descartes, Institut Cochin, Paris, France
    FASEB J 26:4584-91. 2012
    ..proliferation in BAT of double-mutant newborns was associated with overexpression of the brown fat-specific marker Ucp1. More strikingly, expression of the master key gene Prdm16 involved in the switch between myogenic and brown ..
  67. doi Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals
    Sohei Tsukita
    Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Cell Metab 16:825-32. 2012
    ..Thus, this intertissue energy-saving system may contribute to determining obesity predisposition...
  68. ncbi Effects of forced uncoupling protein 1 expression in 3T3-L1 cells on mitochondrial function and lipid metabolism
    Yaguang Si
    Department of Biology, Tufts University, Medford, MA 02155, USA
    J Lipid Res 48:826-36. 2007
    ..tissue, which is present in rodents but not in adult humans, expresses the mitochondrial uncoupling protein 1 (UCP1) that promotes cellular energy dissipation as heat...
  69. pmc Inflammation induced by RAW macrophages suppresses UCP1 mRNA induction via ERK activation in 10T1/2 adipocytes
    Tomoya Sakamoto
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Am J Physiol Cell Physiol 304:C729-38. 2013
    Recently, it has been demonstrated that uncoupling protein-1 (UCP1)-expressing white adipocytes (brown-like adipocytes) are important for energy expenditure in white adipose tissue (WAT), in which energy expenditure decreases under obese ..
  70. doi Fatty acid-binding protein 3 stimulates glucose uptake by facilitating AS160 phosphorylation in mouse muscle cells
    Tatsuya Kusudo
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487 8501, Japan
    Genes Cells 16:681-91. 2011
    ..FABP3 may also contribute to AS160 phosphorylation by maintaining insulin-dependent Akt activation in the cells under a lipotoxic condition...
  71. pmc Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1)
    Kichoon Lee
    Department of Nutritional Sciences and Toxicology, and Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    J Clin Invest 111:453-61. 2003
    ..These findings demonstrate the inhibition of adipogenesis by Pref-1 in vivo and the resulting impairment of adipocyte function that leads to the development of metabolic abnormalities...
  72. ncbi Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat
    Ann Allen Coulter
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Physiol Genomics 14:139-47. 2003
    ..novel regulatory factors controlling induction of the brown adipocyte-specific mitochondrial uncoupling protein (Ucp1) mRNA in the retroperitoneal white fat depot, we previously mapped quantitative trait loci (QTLs) that control this ..
  73. ncbi Evodiamine improves diet-induced obesity in a uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling
    Ting Wang
    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487 8501, Japan
    Endocrinology 149:358-66. 2008
    ..is an alkaloidal compound with antiobesity effects that have been thought to be due to uncoupling protein-1 (UCP1) thermogenesis similar to the effects of capsaicin, but the underlying mechanisms are poorly understood...
  74. pmc Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene
    Wei Chen
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Cell 35:755-68. 2009
    ..Here, we have employed the PPARgamma- and TRalpha-activated brown adipose tissue-specific UCP-1 enhancer to investigate mechanistic aspects of PGC-1alpha function...
  75. pmc Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis
    Miriam O Ribeiro
    Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 151:432-40. 2010
    ..Heat production from BAT requires sympathetic nervous system stimulation, T(3), and uncoupling protein 1 (UCP1) expression...
  76. doi Uncoupling protein-1 is not leaky
    Irina G Shabalina
    The Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1797:773-84. 2010
    The activity of uncoupling protein-1 (UCP1) is rate-limiting for nonshivering thermogenesis and diet-induced thermogenesis...
  77. pmc Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice
    Joseph D Bruton
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    J Physiol 588:4275-88. 2010
    ..Shivering is successively replaced by the recruitment of uncoupling protein-1 (UCP1)-dependent heat production in brown adipose tissue...
  78. ncbi Characterization and functional expression of a cDNA encoding egasyn (esterase-22): the endoplasmic reticulum-targeting protein of beta-glucuronidase
    M Ovnic
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229
    Genomics 11:956-67. 1991
    ..The features of the deduced amino acid sequence of the egasyn cDNA are compared with previously characterized carboxylesterases and with other lumenal ER proteins...
  79. ncbi An interspecific backcross linkage map of mouse chromosome 8
    J D Ceci
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 6:72-9. 1990
    ..Genes that were mapped in this study include Act-6, Aprt, Aprt-ps1, Emv-2, Es-N, Hp, Insr, Mt-1, Plat, Psx-8, Ucp, and Zfp-4. New regions of homology were established between mouse chromosome 8 and human chromosomes 8 and 19...
  80. ncbi The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains
    L P Kozak
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Biol Chem 263:12274-7. 1988
    ..The 5'-untranslated region of the mRNA is composed of 231 nucleotides, and the 3'-untranslated region contains 81 nucleotides prior to addition of the poly(A) tail...
  81. ncbi Structural organization of the mouse glycophorin A gene
    M Terajima
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai
    J Biochem 116:1105-10. 1994
    ..The upstream regulatory region of the mouse gene consists of multiple motifs for DNA binding factors that may be required for its erythroid-specific expression...
  82. ncbi Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse
    A Milatovich
    Department of Genetics, Stanford University Medical Center, California 94305
    Somat Cell Mol Genet 20:75-86. 1994
    ....
  83. ncbi Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice
    J Doyle
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
    Mamm Genome 8:113-20. 1997
    ....
  84. ncbi High expression of uncoupling protein 2 in foetal liver
    Z Hodny
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague
    FEBS Lett 425:185-90. 1998
    ..Neither UCP1 nor UCP3 mRNA was expressed in foetal liver...
  85. ncbi The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling")
    A Matthias
    Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 274:28150-60. 1999
    The bioenergetics of brown fat mitochondria isolated from UCP1-ablated mice were investigated...
  86. pmc C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue
    S S Chen
    Laboratory of Molecular Pathology, Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Mol Cell Biol 20:7292-9. 2000
    ..Moreover, our studies with the C/ebpalpha(beta/beta) mice provide new insights into the nonredundant functions of C/EBPalpha and C/EBPbeta on gene regulation in WAT...
  87. ncbi Mitochondrial efficiency: lessons learned from transgenic mice
    M E Harper
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Ont, Canada K1H 8M5
    Biochim Biophys Acta 1504:159-72. 2001
    ..affect the coupling of energy substrate oxidation to ATP synthesis, and thus, mice in which the uncoupling protein (Ucp) genes are modified are discussed extensively...
  88. ncbi Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice
    W E Hofmann
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 276:12460-5. 2001
    An interaction between free fatty acids and UCP1 (uncoupling protein-1) leading to de-energization of mitochondria was assumed to be a key event for triggering heat production in brown fat. Recently, Matthias et al...
  89. ncbi Phenotypic characteristics of adipocytes generated from Meckel's chondrocytes in response to chick serum in vitro
    Kiyoto Ishizeki
    Department of Oral Anatomy, School of Dentistry, Iwate Medical University, Chuo dori 1 3 27, Morioka 020 8505, Japan
    Cell Tissue Res 309:251-60. 2002
    ..staining of adipocytes with stage-specific antibodies revealed the presence of immunoreactive uncoupling protein (UCP-1) and peroxisome proliferator-activated receptor (PPARgamma) in immature adipocytes, and leptin and glucose ..
  90. ncbi Cidea-deficient mice have lean phenotype and are resistant to obesity
    Zhihong Zhou
    Laboratories of Apoptosis Regulation, Institute of Molecular and Cell Biology, 30 Medical Dr, Singapore 117609, Singapore
    Nat Genet 35:49-56. 2003
    ..important for adaptive thermogenesis and energy expenditure, is mediated by the mitochondrial uncoupling protein1 (Ucp1) that uncouples ATP generation and dissipates the energy as heat...
  91. ncbi Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 mice
    Jun ichi Suto
    Department of Molecular Biology and Immunology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305 8602, Japan
    Biochem Genet 41:325-41. 2003
    ..Identification of distinct, but related traits in an identical chromosomal region will facilitate revealing the responsible gene...
  92. ncbi Molecular phenotyping of the mouse ky mutant reveals UCP1 upregulation at the neuromuscular junctions of dystrophic soleus muscle
    G Blanco
    MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK
    Neuromuscul Disord 14:217-28. 2004
    ..Altogether, the data presented suggest that the ky muscular dystrophy develops by a distinctive pathogenic mechanism...
  93. ncbi Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption
    J Magnus Fredriksson
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Sweden
    FEBS Lett 579:5680-4. 2005
    ..of hypoxic oxygen levels by thermogenic processes, we cold-exposed wild-type mice, as well as uncoupling protein-1 (UCP1)-ablated mice in which no thermogenesis in brown adipocytes can be induced...
  94. pmc Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively
    Irina G Shabalina
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochem J 399:405-14. 2006
    In brown-fat mitochondria, fatty acids induce thermogenic uncoupling through activation of UCP1 (uncoupling protein 1). However, even in brown-fat mitochondria from UCP1-/- mice, fatty-acid-induced uncoupling exists...
  95. ncbi UCP1-independent thermogenesis in white adipose tissue of cold-acclimated Ucp1-/- mice
    Jozef Ukropec
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 281:31894-908. 2006
    Apart from UCP1-based nonshivering thermogenesis in brown adipocytes, the identity of thermogenic mechanisms that can be activated to reduce a positive energy balance is largely unknown...
  96. ncbi Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice
    Keiko Higuchi
    Department of Anatomy, Biology, and Medicine, Internal Medicine 1, Faculty of Medicine, Oita University, 1 1 Idai ga oka, Hasama cho, Yufu City, Oita 879 5593, Japan
    Endocrinology 148:2690-7. 2007
    ..Additionally, apelin treatment increased mRNA expression of UCP1, a marker of peripheral energy expenditure, in brown adipose tissue (BAT) and of UCP3, a regulator of fatty acid ..
  97. ncbi Images of mitochondrial UCP 1 in mouse thymocytes using confocal microscopy
    ALISON E ADAMS
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Biochim Biophys Acta 1777:115-7. 2008
    The aim of this study was to demonstrate the constitutive expression of mitochondrial uncoupling protein 1 (UCP 1) in pure thymocytes using laser scanning confocal microscopic imagery...
  98. pmc Effect of uncoupling protein-1 expression on 3T3-L1 adipocyte gene expression
    Fatih S Senocak
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX 77843 3122, United States
    FEBS Lett 581:5865-71. 2007
    The mitochondrial respiratory uncoupling protein 1 (UCP1) partially uncouples substrate oxidation and oxidative phosphorylation to promote the dissipation of cellular biochemical energy as heat in brown adipose tissue...
  99. doi Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism
    Irina G Shabalina
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1777:642-50. 2008
    In the present investigation, we have utilized the availability of UCP1(-/-) mice to examine a wide range of previously proposed lipid activators of Uncoupling Protein 1 (UCP1) in its native environment, i.e. in the brown-fat cells...
  100. doi Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects
    Irina G Shabalina
    The Wenner Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
    Biochim Biophys Acta 1797:968-80. 2010
    Mice lacking the thermogenic mitochondrial membrane protein UCP1 (uncoupling protein 1)--and thus all heat production from brown adipose tissue--can still adapt to a cold environment (4 degrees C) if successively transferred to the cold...
  101. pmc The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
    Na Zhang
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 11:364-78. 2010
    ..These results demonstrate that FIH acts to a significant degree through the nervous system to regulate metabolism...

Research Grants2

  1. ROLE OF INSULIN AND IGF-1 ON BROWN ADIPOCYTES
    Yu Hua Tseng; Fiscal Year: 2003
    ..Accomplishment of the proposed studies will further our understanding on hormonal controls of metabolism and survival of brown adipocytes. ..
  2. Role of BMPs on Brown Adipogenesis and Thermogenesis
    Yu Hua Tseng; Fiscal Year: 2006
    ..the expression of peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) and uncoupling protein-1 (UCP-1)...