Ucn

Summary

Gene Symbol: Ucn
Description: urocortin
Alias: Mpv17, Ucn1, urocortin
Species: mouse

Top Publications

  1. ncbi Modulation of T-type Ca2+ channels by corticotropin-releasing factor through protein kinase C pathway in MN9D dopaminergic cells
    Yonjung Kim
    Department of Physiology, Sungkyunkwan University School of Medicine, Suwon 440 746, South Korea
    Biochem Biophys Res Commun 358:796-801. 2007
  2. ncbi Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior
    Douglas E Vetter
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Genet 31:363-9. 2002
  3. pmc Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress
    E M Fekete
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Br J Pharmacol 164:1959-75. 2011
  4. pmc Leptin signaling modulates the activity of urocortin 1 neurons in the mouse nonpreganglionic Edinger-Westphal nucleus
    Lu Xu
    Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 GL Nijmegen, The Netherlands
    Endocrinology 152:979-88. 2011
  5. pmc A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery
    Adi Neufeld-Cohen
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 107:19020-5. 2010
  6. pmc Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine
    W J Giardino
    Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 10:78-89. 2011
  7. pmc Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice
    Anita Cservenka
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Brain Res 1319:33-43. 2010
  8. pmc Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism
    Raul Pastor
    Departments of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 105:9070-5. 2008
  9. pmc Galectin-1 overexpression in endometriosis and its regulation by neuropeptides (CRH, UCN) indicating its important role in reproduction and inflammation
    Aikaterini Vergetaki
    Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion, Greece
    PLoS ONE 9:e114229. 2014
  10. doi Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum
    Roeland Buckinx
    Laboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Cell Tissue Res 359:453-63. 2015

Scientific Experts

  • Christos Tsatsanis
  • Keiichi Ikeda
  • T Kozicz
  • A Z Weitemier
  • Veronique Fabre
  • Alena A Zalutskaya
  • Lu Xu
  • Andrey E Ryabinin
  • Roeland Buckinx
  • Aikaterini Vergetaki
  • Matthew J Purser
  • N M Derks
  • Charlotte E Combs
  • E M Fekete
  • William J Giardino
  • W J Giardino
  • Bernard Okere
  • Anita Cservenka
  • Adi Neufeld-Cohen
  • Eric W Roubos
  • Raul Pastor
  • Jin Tao
  • Nicole M Derks
  • Yonjung Kim
  • Elena Gonzalez-Rey
  • Jae Sun Choi
  • W W Vale
  • Mária Bagyánszki
  • Leela Rani Avula
  • Luc Van Nassauw
  • Dirk Adriaensen
  • Jean Pierre Timmermans
  • Luca Sabatini
  • Thomas Vrekoussis
  • Eirini Taliouri
  • Douglas E Vetter
  • Xiaozhong Wang
  • Evangelia A Papakonstanti
  • Udo Jeschke
  • Antonis Makrigiannakis
  • Zi C Wang
  • Denise D Belsham
  • Prasad S Dalvi
  • Timothy J Chambers
  • Hashethra Kumar
  • W Zuure
  • C S Molnar
  • Karen Fuller
  • M Watanabe
  • E W Roubos
  • Kevin M Lawrence
  • Y Wei
  • C Ledent
  • D Zelena
  • Grisha Pirianov
  • Anthony P Albert
  • James McCormick
  • E Hrabovszky
  • O Pinter
  • Ian C Locke
  • S Wu
  • Sanne Bouwhuis
  • E Spangler
  • A E Ryabinin
  • T J Phillips
  • A Szucs
  • Wim J J M Scheenen
  • Eric Willem Roubos
  • D M Cote
  • P Cottone
  • Christa M Patterson
  • E P Zorrilla
  • Davelle L Cocking
  • J Rivier
  • A M J Anacker
  • G F Koob
  • Carol F Elias
  • Christopher L Cunningham
  • R Pastor
  • Simranjit Kaur
  • M P Stenzel-Poore
  • Y Zhao
  • V Sabino
  • Martin G Myers
  • J Li
  • Rebecca L Leshan
  • Alon Chen
  • Michael M Tsoory
  • Wylie W Vale
  • Dawn M Cote

Detail Information

Publications30

  1. ncbi Modulation of T-type Ca2+ channels by corticotropin-releasing factor through protein kinase C pathway in MN9D dopaminergic cells
    Yonjung Kim
    Department of Physiology, Sungkyunkwan University School of Medicine, Suwon 440 746, South Korea
    Biochem Biophys Res Commun 358:796-801. 2007
    ..The application of CRF-related peptide, urocortin 1, reversibly inhibited T-type Ca(2+) currents, which was a major Ca(2+) channel in the cells...
  2. ncbi Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior
    Douglas E Vetter
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Genet 31:363-9. 2002
    b>Urocortin is a member of the corticotropin-releasing hormone peptide family and is found in many discrete brain regions...
  3. pmc Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress
    E M Fekete
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Br J Pharmacol 164:1959-75. 2011
    Infusion of corticotropin-releasing factor (CRF)/urocortin (Ucn) family peptides suppresses feeding in mice. We examined whether rats show peripheral CRF/Ucn-induced anorexia and determined its behavioural and pharmacological bases.
  4. pmc Leptin signaling modulates the activity of urocortin 1 neurons in the mouse nonpreganglionic Edinger-Westphal nucleus
    Lu Xu
    Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6500 GL Nijmegen, The Netherlands
    Endocrinology 152:979-88. 2011
    ..This nucleus hosts the majority of urocortin 1 (Ucn1) neurons in the rodent brain, and because Ucn1 is a potent satiety hormone and electrical lesioning of ..
  5. pmc A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery
    Adi Neufeld-Cohen
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 107:19020-5. 2010
    ..The urocortin neuropeptides are members of the corticotropin-releasing factor family and are associated with the central ..
  6. pmc Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine
    W J Giardino
    Department of Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health and Science University, Portland, OR 97239, USA
    Genes Brain Behav 10:78-89. 2011
    ..mice, each deficient for a single component of the CRF system: CRF-R1, CRF-R2, CRF, or the CRF-related peptide Urocortin 1 (Ucn1)...
  7. pmc Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice
    Anita Cservenka
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Brain Res 1319:33-43. 2010
    b>Urocortin 1 (Ucn 1) is an endogenous corticotropin releasing factor (CRF)-related peptide...
  8. pmc Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism
    Raul Pastor
    Departments of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 105:9070-5. 2008
    ..Because CRF1 receptors are also activated by urocortin-1 (Ucn1), we tested Ucn1 knockout mice for EtOH sensitization and found normal sensitization in this genotype...
  9. pmc Galectin-1 overexpression in endometriosis and its regulation by neuropeptides (CRH, UCN) indicating its important role in reproduction and inflammation
    Aikaterini Vergetaki
    Department of Obstetrics and Gynecology, Medical School, University of Crete, Heraklion, Greece
    PLoS ONE 9:e114229. 2014
    ..Also, the neuropeptides, corticotropin releasing hormone (CRH) and urocortin (UCN) and their receptors are expressed in eutopic and ectopic endometrium showing a differential expression ..
  10. doi Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum
    Roeland Buckinx
    Laboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Cell Tissue Res 359:453-63. 2015
    ..Furthermore, UCN2 and UCN3 were found in the musculature. During acute schistosomiasis, UCN1 showed an increased immunoreactivity in blood vessels and UCN3 was de novo expressed mainly in submucous neurons...
  11. pmc The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo
    Matthew J Purser
    Department of Physiology, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 8:e61616. 2013
    ..line that endogenously expresses the CNTF receptor to examine the direct effects of CNTF on mRNA levels of urocortin-1, urocortin-2, agouti-related peptide, brain-derived neurotrophic factor, and neurotensin...
  12. doi Urocortin is a novel regulator of osteoclast differentiation and function through inhibition of a canonical transient receptor potential 1-like cation channel
    Charlotte E Combs
    Department of Cellular Pathology, St George s, University of London, Cranmer Terrace, London SW17 ORE, UK
    J Endocrinol 212:187-97. 2012
    This study investigated the role of urocortin (UCN), a member of the corticotrophin-releasing factor (CRF) family of peptides, in osteoclast maturation and function. We found that 10(-7) M UCN significantly (P<0...
  13. doi Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse Edinger-Westphal nucleus
    Bernard Okere
    Department of Animal Biology, University of Modena and Reggio Emilia, Via Campi, 213 D, 41100 Modena, Italy
    Brain Res 1317:92-9. 2010
    Central stress regulatory pathways utilize various neuropeptides, such as urocortin-1 (Ucn1) and cocaine- and amphetamine-regulated transcript peptide (CART)...
  14. ncbi Impaired adaptation to repeated restraint and decreased response to cold in urocortin 1 knockout mice
    Alena A Zalutskaya
    Endocrine Unit, Massachusetts General Hospital, Thier 1051, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 293:E259-63. 2007
    b>Urocortin 1 (UCN1) is a corticotropin-releasing factor (CRF)-like peptide whose role in stress is not well characterized...
  15. doi Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress
    N M Derks
    Department of Cellular Animal Physiology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen, Nijmegen, The Netherlands
    J Neuroendocrinol 24:1447-61. 2012
    Neurones in the centrally projecting Edinger-Westphal nucleus (EWcp) are the main site of urocortin 1 (Ucn1) synthesis in the mammalian brain, and are assumed to play a role in the stress response of the animal...
  16. pmc Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference
    William J Giardino
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e26997. 2011
    ..involvement of neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) containing the neuropeptide Urocortin-1 (Ucn1) in excessive ethanol (EtOH) intake and EtOH sensitivity...
  17. ncbi Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, School of Medicine, University of Crete, Heraklion, Crete GR 710 03, Greece
    FEBS Lett 579:4259-64. 2005
    ..In conclusion, our data suggest that endogenous CRFR2 ligands exert an anti-inflammatory effect via induction of macrophage apoptosis...
  18. ncbi Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1
    Christos Tsatsanis
    Department of Clinical Chemistry Biochemistry, University of Crete, Greece
    J Immunol 176:1869-77. 2006
    ..Exposure of peritoneal macrophages and RAW 264.7 cells to CRF, UCN1, or UCN2 up-regulated TLR4 mRNA and protein levels...
  19. ncbi Presence of estrogen receptor beta in urocortin 1-neurons in the mouse non-preganglionic Edinger-Westphal nucleus
    Nicole M Derks
    Department of Cellular Animal Physiology, Integrative Physiology, EURON Graduate School for Neuroscience, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Gen Comp Endocrinol 153:228-34. 2007
    Adaptation to stress involves the activity of the hypothalamic-pituitary-adrenal (HPA-) axis. Urocortin 1 (Ucn1) coordinates responses to stressors...
  20. pmc Corticotropin-releasing factor (CRF) and urocortin promote the survival of cultured cerebellar GABAergic neurons through the type 1 CRF receptor
    Jae Sun Choi
    Department of Anatomy, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea
    J Korean Med Sci 21:518-26. 2006
    ..investigated the trophic role for CRF family of peptides by culturing cerebellar neurons in the presence of CRF, urocortin or urocortin II...
  21. doi Regulation of urocortin I and its related peptide urocortin II by inflammatory and oxidative stresses in HL-1 cardiomyocytes
    Keiichi Ikeda
    Department of Pharmacology, The Jikei University School of Medicine, Tokyo, Japan
    J Mol Endocrinol 42:479-89. 2009
    Despite our knowledge on the regulation of urocortin (Ucn) I and its related peptides in the heart, the possible involvement of cardiovascular stress substances, such as cytokines or angiotensin II (Ang II), on this regulation remains to ..
  22. pmc Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response
    Elena Gonzalez-Rey
    Instituto de Parasitologia y Biomedicina, Consejo Superior de Investigaciones Cientificas, Avd Conocimiento, Parque Tecnologico Ciencias de la Salud, Granada 18100, Spain
    Am J Pathol 168:1921-30. 2006
    b>Urocortin 1 (UCN) and adrenomedullin (AM) are two neuropeptides that have emerged as potential endogenous anti-inflammatory factors based on their production by and binding to immune cells...
  23. ncbi Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice
    A Z Weitemier
    Department of Behavioral Neuroscience, Oregon Health and Science University and Portland Alcohol Research Center, Portland, OR 97239, USA
    Neuroscience 137:1439-45. 2006
    The midbrain-localized Edinger-Westphal nucleus is a major site of production of urocortin 1...
  24. doi Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1
    Veronique Fabre
    Universite Pierre et Marie Curie PARIS6, Faculte de Medecine Pierre et Marie Curie, Site Pitié Salpêtrière, IFR 70 des Neurosciences, UMR S677, Paris, F 75013, France
    Eur Neuropsychopharmacol 21:33-44. 2011
    ..Among genes with altered expression, the gene encoding the neuropeptide urocortin 1 was down-regulated in 5-HTT KO and up-regulated in 5-HTT TG mice...
  25. ncbi Urocortin expression in the Edinger-Westphal nucleus is down-regulated in transgenic mice over-expressing neuronal corticotropin-releasing factor
    T Kozicz
    Department of Cellular Animal Physiology, Nijmegen Institute for Neurosciences, University of Nijmegen, Nijmegen, The Netherlands
    Neuroscience 123:589-94. 2004
    ..b>Urocortin (Ucn), a recently discovered member of the CRF peptide family may play a role in the pathophysiology of stress-..
  26. pmc Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response
    Xiaozhong Wang
    Department of Molecular and Human Genetics, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:6605-10. 2002
    ..Its actions are mediated through two receptors, Crhr1 and Crhr2. Urocortin (Ucn), a Crh-related neuropeptide and the postulated endogenous ligand for Crhr2, is a potential mediator of ..
  27. ncbi Separate locations of urocortin and its receptors in mouse testis: function in male reproduction and the relevant mechanisms
    Jin Tao
    Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, PR China
    Cell Physiol Biochem 19:303-12. 2007
    b>Urocortin (UCN), a newly identified corticotrophin-releasing-factor (CRF) related peptide, has been demonstrated to play important roles in female reproductive system...
  28. ncbi Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency
    S C Weninger
    Howard Hughes Medical Institute, Division of Endocrinology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 141:256-63. 2000
    b>Urocortin is a 40-amino acid mammalian peptide related to CRH and urotensin. The physiological role of urocortin is unknown, but it has been postulated to serve some of the functions previously attributed to CRH...
  29. ncbi Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice
    A Asakawa
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Gastroenterology 116:1287-92. 1999
    Gastric emptying plays an important role in regulating food intake. This study was designed to investigate whether intraperitoneally injected urocortin reduces gastric emptying, feeding, and body weight in lean and ob/ob obese mice.
  30. ncbi The structures of the mouse and human urocortin genes (Ucn and UCN)
    L Zhao
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Genomics 50:23-33. 1998
    The mouse and human urocortin genes (Ucn and UCN, respectively) have been isolated, characterized, and found to have very similar structures...