Ubc

Summary

Gene Symbol: Ubc
Description: ubiquitin C
Alias: 2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb, polyubiquitin-C, polyubiquitin C
Species: mouse

Top Publications

  1. ncbi Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C
    N S Yee
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021
    J Biol Chem 269:31991-8. 1994
  2. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
  3. ncbi Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    Michael McMahon
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 278:21592-600. 2003
  4. ncbi Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis
    Tommaso Nastasi
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Dev Cell 6:269-82. 2004
  5. pmc Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation
    Erik J Eide
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Mol Cell Biol 25:2795-807. 2005
  6. ncbi Regulation of T cell development by the deubiquitinating enzyme CYLD
    William W Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Nat Immunol 7:411-7. 2006
  7. ncbi Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Cell 125:665-77. 2006
  8. pmc Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    Jun Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:3042-9. 2006
  9. ncbi TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation
    Seiji Shiraishi
    Department of Biology, Faculty of Science, Chiba University, Chiba 263 8522, Japan
    J Biol Chem 282:9017-28. 2007
  10. pmc The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance
    Kwon Yul Ryu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    EMBO J 26:2693-706. 2007

Research Grants

  1. The Role of MicroRNA in Hepatocarcinogenesis
    Kalpana Ghoshal; Fiscal Year: 2007
  2. GLUCOCORTICOID ATTENUATED RESPONSE GENES IN INFLAMMATION
    Jeffrey Smith; Fiscal Year: 2001
  3. RESPONSE TO INJURY IN GAMMAGLUTAMYL CYCLE DEFICIENT MICE
    GEETHA HABIB; Fiscal Year: 2004
  4. FUNCTION OF GAMMA GLUTAMYL LEUKOTRIENASE
    GEETHA HABIB; Fiscal Year: 2005
  5. RIP2 kinase's function in Innate Immunity
    Derek Abbott; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications159 found, 100 shown here

  1. ncbi Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C
    N S Yee
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021
    J Biol Chem 269:31991-8. 1994
    ..In summary, KL-induced internalization of KL.Kit complexes and ubiquitination/degradation require an active kinase. By contrast, proteolytic cleavage of Kit mediated by protein kinase C activation is independent of kinase activity...
  2. pmc beta-catenin is a target for the ubiquitin-proteasome pathway
    H Aberle
    Max Planck Institute for Immunobiology, Department of Molecular Embryology, Freiburg, Germany
    EMBO J 16:3797-804. 1997
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin...
  3. ncbi Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
    Michael McMahon
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 278:21592-600. 2003
    ..Within Nrf2, the N-terminal Neh2 domain is identified as the redox-sensitive degron. These data suggest that Keap1 negatively regulates Nrf2 by both enhancing its rate of proteasomal degradation and altering its subcellular distribution...
  4. ncbi Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis
    Tommaso Nastasi
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Dev Cell 6:269-82. 2004
    ..These findings reveal a novel mechanism of regulation of Mb-beta-catenin and the role of this pool of the protein in myofibrillogenesis, and implicate the Ozz-E3 ligase in the process of myofiber differentiation...
  5. pmc Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation
    Erik J Eide
    Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA
    Mol Cell Biol 25:2795-807. 2005
    ..Cell culture-based biochemical assays combined with measurement of cell-based rhythm complement genetic studies to elucidate basic mechanisms controlling the mammalian clock...
  6. ncbi Regulation of T cell development by the deubiquitinating enzyme CYLD
    William W Reiley
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Nat Immunol 7:411-7. 2006
    ..Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells...
  7. ncbi Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling
    Ramin Massoumi
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Cell 125:665-77. 2006
    ....
  8. pmc Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    Jun Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:3042-9. 2006
    ..These results suggest that CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo...
  9. ncbi TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation
    Seiji Shiraishi
    Department of Biology, Faculty of Science, Chiba University, Chiba 263 8522, Japan
    J Biol Chem 282:9017-28. 2007
    ..TIP120B is proposed to be a novel regulator for myogenesis...
  10. pmc The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance
    Kwon Yul Ryu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    EMBO J 26:2693-706. 2007
    b>UbC is one of two stress-inducible polyubiquitin genes in mammals and is thought to supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during episodes of cellular stress...
  11. ncbi Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors
    Stéphane C Boutet
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 130:349-62. 2007
    ..These results reveal an important mechanism of Pax3 regulation in muscle progenitors and an unrecognized role of protein monoubiquitination in mediating proteasomal degradation...
  12. pmc Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL 33136, USA
    EMBO J 26:3910-22. 2007
    ..Thus, TAX1BP1 is pivotal for the termination of NF-kappaB and JNK signaling by functioning as an essential regulator of A20...
  13. pmc Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
    Kit I Tong
    Graduate School of Comprehensive Human Sciences, Center for TARA, JST ERATO Environmental Response Project, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Mol Cell Biol 27:7511-21. 2007
    ..Together with the results from calorimetric and functional studies, we conclude that different electrostatic potentials primarily define the ETGE and DLG motifs as a hinge and latch that senses the oxidative/electrophilic stress...
  14. ncbi Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl
    Jianmin Sun
    Experimental Clinical Chemistry, Department of Laboratory Medicine, Lund University, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Exp Cell Res 313:3935-42. 2007
    ....
  15. pmc SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
    Jinke Cheng
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA
    Cell 131:584-95. 2007
    ..These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation...
  16. pmc Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation
    Ssang Taek Lim
    Department of Reproductive Medicine, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC0803, La Jolla, CA 92093, USA
    Mol Cell 29:9-22. 2008
    ..These studies define a scaffolding role for nuclear FAK in facilitating cell survival through enhanced p53 degradation under conditions of cellular stress...
  17. pmc Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination
    Mumtaz Yaseen Balkhi
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Mol Cell Biol 28:7296-308. 2008
    ..Thus, our findings offer a new mechanistic insight into IRF-5 gene induction program through hitherto unknown processes of IRF-5 ubiquitination...
  18. pmc USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1
    Yu Lu
    Polypeptide Laboratory, Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 29:547-58. 2009
    ....
  19. doi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO...
  20. pmc Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
    Mikyoung Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1089-95. 2009
    ..Our findings suggest that Peli1 is a ubiquitin ligase needed for the transmission of TRIF-dependent TLR signals...
  21. pmc Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival
    Ssang Taek Lim
    Department of Reproductive Medicine, Moores Cancer Center, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:1743-53. 2010
    ..Our studies demonstrate that nuclear Pyk2 functions to limit p53 levels, thus facilitating cell growth and survival in a kinase-independent manner...
  22. pmc SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
    Patricia Rada
    Instituto de Investigaciones Biomédicas Alberto Sols UAM CSIC, c Arturo Duperier 4, 28029 Madrid, Spain
    Mol Cell Biol 31:1121-33. 2011
    ..Our results show for the first time that Nrf2 is targeted by GSK-3 for SCF/β-TrCP-dependent degradation. We propose a "dual degradation" model to describe the regulation of Nrf2 under different pathophysiological conditions...
  23. pmc Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin
    Shin Isogai
    Department of Molecular Engineering, Graduate School of Engineering, Kyoto University, Kyoto Daigaku Katsura, Kyoto 615 8510, Japan
    J Biol Chem 286:31864-74. 2011
    ..These observations reveal an autoinhibitory mechanism in the p62 UBA domain and suggest that autoinhibition plays a role in the function of p62...
  24. pmc The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light
    Heather Dehlin Scoma
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 6:e25382. 2011
    ..Rhythmic expression of USP2 in the SCN and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes...
  25. doi p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model
    Hideki Doi
    Department of Neurology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    J Neurosci 33:7710-27. 2013
    ..Our results demonstrate that p62 provides two different therapeutic targets in SBMA pathogenesis: (1) autophagy-dependent degradation and (2) benevolent inclusion formation of the mutant AR...
  26. pmc Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains
    Rui Hao
    Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA
    Mol Cell 51:819-28. 2013
    ..Thus, unanchored ubiquitin chains are key signaling molecules that connect and coordinate the proteasome and autophagy to eliminate toxic protein aggregates...
  27. ncbi Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD
    Ato Wright
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Dev Cell 13:705-16. 2007
    ..These findings establish CYLD as a pivotal deubiquitinating enzyme (DUB) that regulates germ cell apoptosis and spermatogenesis and suggest an essential role for CYLD in controlling the RIP1/NF-kappaB signaling axis in testis...
  28. ncbi Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1
    S Barhite
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco 94110, USA
    Biochim Biophys Acta 1402:95-101. 1998
    ..We suggest that PhLP/SUG1 interaction may target PhLP for proteasomal degradation...
  29. ncbi Proteasomes are involved in the constitutive degradation of growth hormone receptors
    K Takagi
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Setagaya, Tokyo, Japan
    Biol Pharm Bull 24:744-8. 2001
    ..Our results also suggest that ubiquitination of the hGHR itself is unlikely to be the trigger of the proteasome-dependent degradation...
  30. ncbi The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
    ..These results provide evidence for a mechanism whereby p62 serves to regulate the NF-kappaB pathway...
  31. pmc Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A
    Hongyun Li
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Mol Cell Biol 29:919-28. 2009
    ..Our results thus indicate that proteasomal turnover of cyclin G1 is regulated by noncanonical processes...
  32. pmc Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2
    Suryakant K Niture
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201
    J Biol Chem 284:13856-68. 2009
    ....
  33. pmc Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation
    Yue Lei Chen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Biol Chem 284:23481-90. 2009
    ..Collectively, these findings reveal that Smad6 serves as a critical mediator of BMP signal via a functional interaction with Tbx6, thus regulating the activation of Tbx6 downstream genes during cell differentiation...
  34. doi Mineralocorticoid receptor degradation is promoted by Hsp90 inhibition and the ubiquitin-protein ligase CHIP
    Nourdine Faresse
    Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland
    Am J Physiol Renal Physiol 299:F1462-72. 2010
    ..In conclusion, 17-AAG may represent a novel pharmacological tool to interfere with Na(+) reabsorption and hypertension...
  35. doi MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif
    Fumihiko Okumura
    Department of Biochemistry, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Hokkaido, Japan
    Mol Cell Biochem 352:163-72. 2011
    ....
  36. doi Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
    Tatsuya Saitoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Immunity 34:352-63. 2011
    ..However, Viperin was dispensable for the production of type I IFN induced by intracellular nucleic acids. Thus, Viperin mediates its antiviral function via the regulation of the TLR7 and TLR9-IRAK1 signaling axis in pDCs...
  37. pmc The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation
    Michele Lenoue-Newton
    Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 286:17665-71. 2011
    ..Our results reveal that both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation...
  38. pmc NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK
    Xiaojun Xia
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 34:843-53. 2011
    ..Our study identifies a previously unrecognized role for NLRX1 in the negative regulation of TLR-induced NF-κB activation by dynamically interacting with TRAF6 and the IKK complex...
  39. pmc Dlg3 trafficking and apical tight junction formation is regulated by nedd4 and nedd4-2 e3 ubiquitin ligases
    Claude A Van Campenhout
    Institute of Stem Cell Research, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Dev Cell 21:479-91. 2011
    ..Our findings reveal an unexpected evolutionary diversification of the vertebrate Dlg family in basolateral epithelium formation...
  40. pmc Caspase 8 inhibits programmed necrosis by processing CYLD
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Cell Biol 13:1437-42. 2011
    ..In contrast, loss of caspase 8 prevented CYLD degradation, resulting in necrotic death. A CYLD substitution mutation at Asp 215 that cannot be cleaved by caspase 8 switches cell survival to necrotic cell death in response to TNF...
  41. pmc Alix protein is substrate of Ozz-E3 ligase and modulates actin remodeling in skeletal muscle
    Antonella Bongiovanni
    Institute of Biomedicine and Molecular Immunology, National Research Council, 90146 Palermo, Italy
    J Biol Chem 287:12159-71. 2012
    ..These findings suggest that the Ozz-E3 ligase regulates Alix at sites where the actin cytoskeleton undergoes remodeling...
  42. pmc Molecular mechanisms of the inhibitory effects of bovine lactoferrin on lipopolysaccharide-mediated osteoclastogenesis
    Toshihiro Inubushi
    Department of Oral and Maxillofacial Pathobiology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734 8553, Japan
    J Biol Chem 287:23527-36. 2012
    ..Thus, bLF could be a potent therapeutic agent for inflammatory diseases associated with bone destruction, such as periodontitis and rheumatoid arthritis...
  43. pmc The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding Protein β (C/EBPβ)
    Shuo Ye
    Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China
    J Biol Chem 287:26740-8. 2012
    ..Thus, we demonstrate that Nrdp1-mediated ubiquitination and activation of C/EBPβ contributes to a ubiquitin-dependent nonproteolytic pathway that up-regulates Arg1 expression and promotes M2 macrophage polarization...
  44. pmc GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1
    Ana Victoria C Pilar
    Michael G DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    PLoS Pathog 8:e1002773. 2012
    ..We conclude that GogB is an anti-inflammatory effector that helps regulate inflammation-enhanced colonization by limiting tissue damage during infection...
  45. pmc Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms
    Mohamed Ali Maroui
    CNRS, FRE 3235, Universite Paris Descartes, Paris, France
    PLoS ONE 7:e44949. 2012
    ....
  46. doi PPARγ is an E3 ligase that induces the degradation of NFκB/p65
    YongZhong Hou
    Faculty of Medicine, Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Gastrointestinal Research Group, University of Calgary, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Nat Commun 3:1300. 2012
    ..These findings demonstrate that PPARγ E3 ubiquitin ligase activity induces Lys48-linked ubiquitination and degradation of p65, and that this function is critical to terminate NFκB signalling pathway-elicited inflammation and cancer...
  47. pmc Norisoboldine suppresses osteoclast differentiation through preventing the accumulation of TRAF6-TAK1 complexes and activation of MAPKs/NF-κB/c-Fos/NFATc1 Pathways
    Zhi Feng Wei
    State Key Laboratory of Natural Medicines, Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China
    PLoS ONE 8:e59171. 2013
    ....
  48. doi Disruption of polyubiquitin gene Ubc leads to defective proliferation of hepatocytes and bipotent fetal liver epithelial progenitor cells
    Hyejin Park
    Department of Life Science, University of Seoul, Seoul 130 743, Republic of Korea
    Biochem Biophys Res Commun 435:434-40. 2013
    We have previously demonstrated that disruption of polyubiquitin gene Ubc leads to mid-gestation embryonic lethality most likely due to a defect in fetal liver development, which can be partially rescued by ectopic expression of Ub...
  49. doi T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation
    Yuko Watanabe
    Department of Pediatrics, Tohoku University Graduate School of Medicine, Miyagi, Japan
    J Allergy Clin Immunol 132:648-655.e1. 2013
    ..WASP is normally protected from degradation by the Ca(++)-dependent protease calpain and by the proteasome because of its interaction with the WASP-interacting protein...
  50. doi Morphine prevents lipopolysaccharide-induced TNF secretion in mast cells blocking IκB kinase activation and SNAP-23 phosphorylation: correlation with the formation of a β-arrestin/TRAF6 complex
    Iris K Madera-Salcedo
    Departamento de Farmacobiologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, 14330 Mexico City, Mexico
    J Immunol 191:3400-9. 2013
    ..To our knowledge, these findings constitute the first evidence of molecular crosstalk between opioid receptors and the TLR4 signal transduction system in mast cells. ..
  51. pmc Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination
    Hongxia Wang
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298
    J Immunol 191:6010-21. 2013
    ..These results also reinforce the importance of the ER-associated protein quality control machinery and the mode of the Ag delivery in regulating DC-elicited immune outcomes. ..
  52. pmc Regulation of IL-4 receptor signaling by STUB1 in lung inflammation
    Qin Wei
    1 Department of Medicine, Baylor College of Medicine, Houston, Texas and
    Am J Respir Crit Care Med 189:16-29. 2014
    ..However, the regulatory mechanisms underlying IL-4Rα turnover and its signal termination remain elusive...
  53. pmc The role of prolyl hydroxylase domain protein (PHD) during rosiglitazone-induced adipocyte differentiation
    JuYoung Kim
    From the Department of Pharmacology School of Medicine and
    J Biol Chem 289:2755-64. 2014
    ....
  54. pmc P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP
    H R Ko
    Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea
    Cell Death Dis 5:e1131. 2014
    ..Thus, the tumor-suppressing effects of p42 in cancer cells are driven by negative regulation of the p85 subunit of PI3K. ..
  55. pmc Grail controls Th2 cell development by targeting STAT6 for degradation
    Anupama Sahoo
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Commun 5:4732. 2014
    ..Grail interacts with Stat6 and targets it for ubiquitination and degradation. Thus, our results indicate that Grail plays a critical role in controlling Th2 development through a negative feedback loop. ..
  56. pmc Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression
    Annika Klara Giegerich
    a Institute of Biochemistry I Pathobiochemistry Goethe University Frankfurt Faculty of Medicine Frankfurt, Germany
    Autophagy 10:1937-52. 2014
    ..Our observations suggest that autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis. ..
  57. ncbi Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages
    Axel Kallies
    Department of Molecular Genetics, Institute of Molecular Pharmacology, Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Blood 99:3213-9. 2002
    ..Congruently, the expression of a major endosomal/lysosomal protease, cathepsin B, is strongly reduced in ICSBP(-/-) BMMs...
  58. ncbi Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
    Hitoshi Osaka
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Hum Mol Genet 12:1945-58. 2003
    ..These data suggest that UCH L1, with avidity and affinity for ubiquitin, insures ubiquitin stability within neurons. This study is the first to show the function of UCH L1 in vivo...
  59. ncbi A juxtamembrane tyrosine in the colony stimulating factor-1 receptor regulates ligand-induced Src association, receptor kinase function, and down-regulation
    Cynthia M Rohde
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Biol Chem 279:43448-61. 2004
    ..These findings may have implications for the oncogenic conversion of c-Kit and Flt3 with JMD mutations...
  60. ncbi Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability
    Je Seong Won
    Developmental Neurogenetics, Department of Pediatrics Department of Pathology, Medical University of South Carolina, 316 CSB, Charleston, SC 29425, USA
    Free Radic Biol Med 37:1834-44. 2004
    ..To our knowledge, this is the first evidence that cAMP regulates iNOS expression at the posttranslational level in macrophages...
  61. pmc 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal
    Kalpana Ghoshal
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell Biol 25:4727-41. 2005
    ..These results demonstrate a unique mechanism for the selective degradation of DNMT1, the maintenance DNA methyltransferase, by well-known DNA-hypomethylating agents...
  62. pmc The role of Ca2+ in triggering inositol 1,4,5-trisphosphate receptor ubiquitination
    Kamil J Alzayady
    Department of Pharmacology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210 2339, USA
    Biochem J 392:601-6. 2005
    ..We conclude that IP3R ubiquitination and degradation are triggered by the concerted action of IP3- and Ca2+-binding...
  63. pmc TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor
    Thangiah Geetha
    Department of Biological Sciences and Program in Cell and Molecular Biosciences, Auburn University, Auburn, AL, USA
    EMBO J 24:3859-68. 2005
    ..Finally, unlike wild-type NRIF, the K19R NRIF failed to reconstitute p75-mediated apoptosis in nrif-/- neurons. These results reveal a unique mechanism of p75 signaling and a novel role for K63-linked ubiquitin chains...
  64. pmc A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein
    Qingyu Qin
    Laboratory of Molecular Biochemistry and 6Laboratory of Genome and Biosignal, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    J Cell Biol 172:497-504. 2006
    ..We propose that CRAG is a modulator of PML function and dynamics in ROS signaling and is protectively involved in the pathogenesis of polyglutamine diseases...
  65. ncbi Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation
    Ruoyun Tan
    Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 17:2781-91. 2006
    ..Preservation of SnoN by inhibiting its degradation may be a novel strategy for targeting hyperactive Smad signaling in renal fibrotic diseases...
  66. pmc p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration
    Mark R Frey
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA
    EMBO J 25:5683-92. 2006
    ..Together these data position p38 as a modulator of ligand-stimulated EGFR processing and demonstrate that this processing has a profound impact on the cellular outcome of EGFR signaling...
  67. ncbi Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination
    Guillaume van Niel
    Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, P O Box 80 176, NL 3508 TD, Utrecht, The Netherlands
    Immunity 25:885-94. 2006
    ..Together, these data provide a molecular basis for the regulation of MHC class II-mediated antigen presentation by DCs...
  68. pmc The anaphase-promoting complex coordinates initiation of lens differentiation
    George Wu
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15312, USA
    Mol Biol Cell 18:1018-29. 2007
    ..Thus, Cdh1/APC is crucial to the coordination of cell cycle progression and the initiation of lens differentiation through mediating TGF-beta-signaling-induced destruction of SnoN...
  69. pmc TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation
    Taisuke Kajino
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Biol Chem 282:9475-81. 2007
    ..Inactivation of TAK1 prevented TGF-beta-induced SnoN degradation and impaired induction of the TGF-beta-responsive genes. These data suggest that TAK1 modulates TGF-beta-dependent cellular responses by targeting SnoN for degradation...
  70. pmc Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    J Clin Invest 117:2459-67. 2007
    ..These findings provide what we believe are new insights into the molecular basis of skeletal muscle function and have important implications for possible therapeutic interventions into muscular diseases...
  71. pmc Masking of a nuclear signal motif by monoubiquitination leads to mislocalization and degradation of the regulatory enzyme cytidylyltransferase
    Bill B Chen
    University of Iowa, Department of Biochemistry, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Mol Cell Biol 29:3062-75. 2009
    ..These results unravel a unique molecular mechanism whereby monoubiquitination governs the trafficking and life span of a critical regulatory enzyme in vivo...
  72. pmc Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation
    Kathleen Corcoran
    Department of Immunobiology, University of Arizona, Tucson, AZ 85724, USA
    J Biol Chem 284:17475-87. 2009
    ..This mechanism of substrate recruitment by adapter proteins may explain the ability of some E3 ligases, including cellular ERAD E3 ligases, to specifically target the ubiquitination of multiple substrates that are unrelated in sequence...
  73. pmc Impediment of NEMO oligomerization inhibits osteoclastogenesis and osteolysis
    Isra Darwech
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 108:1337-45. 2009
    ..Thus, NEMO presents itself as a promising target for anti-osteolytic intervention...
  74. ncbi Mechanisms of antibody-mediated insulin-like growth factor I receptor (IGF-IR) down-regulation in MCF-7 breast cancer cells
    Masahiro Ohtani
    Department of Applied Biochemistry, Tokai University School of Engineering, Hiratsuka, Kanagawa, Japan
    Biosci Trends 3:131-8. 2009
    ....
  75. pmc RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter
    Benjamin Ko
    Department of Medicine, University of Chicago, Illinois, USA
    Am J Physiol Renal Physiol 299:F300-9. 2010
    ..These findings confirmed that the PE effect on NCC is mediated by endocytosis of NCC. Furthermore, ubiquitination of NCC is essential for this process and this ubiquitination is dependent upon RasGRP1-mediated ERK1/2 activation...
  76. doi Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
    Ingrid E Wertz
    Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA
    Nature 471:110-4. 2011
    ..Our findings suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics...
  77. pmc Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy
    Congfeng Xu
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    FASEB J 25:2700-10. 2011
    ..Taken together, our data revealed that by maintaining the homeostasis of Beclin 1, Hsp90 plays a novel role in TLR-mediated autophagy...
  78. pmc Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism
    M Ali Bangash
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:758-72. 2011
    ..Shank3(+/ΔC) mice show behavioral deficits suggestive of autism and reduced NMDA receptor function. These studies reveal a mechanism distinct from haploinsufficiency by which mutations of Shank3 can evoke an autism-like disorder...
  79. pmc RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation
    Justine P Lu
    Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 286:24426-33. 2011
    ..Thus, RNF170 plays an essential role in IP(3) receptor processing via the ubiquitin-proteasome pathway...
  80. doi Plk1-mediated phosphorylation of UAP56 regulates the stability of UAP56
    Fuyin Xiong
    Beijing Institute of Biotechnology, Beijing 100071, People s Republic of China
    Mol Biol Rep 39:1935-42. 2012
    ..Our results will be helpful in further understanding mRNA metabolism, cell cycle progression, and the link between mRNA metabolism and cellular function...
  81. doi Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system
    Eddy T H Goh
    MRC Protein Phosphorylation Unit and Scottish Institute for Cell Signalling, Sir James Black Centre, University of Dundee, Dundee DD1 5EH, Scotland, U K
    Biochem J 441:339-46. 2012
    ..The activation of Pellino 1 provides the first direct readout for IRAK1 catalytic activity in cells...
  82. pmc The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax
    Bethann N Johnson
    Department of Neurology, Brigham and Women s Hospital, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:6283-8. 2012
    ..These data suggest that Bax is the primary substrate responsible for the antiapoptotic effects of parkin, and provide mechanistic insight into at least a subset of the mitochondrial effects of parkin...
  83. pmc Extracellular signal-regulated kinase (ERK) regulates cortactin ubiquitination and degradation in lung epithelial cells
    Jing Zhao
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 287:19105-14. 2012
    ..These results provide evidence that LPS modulation of cortactin stability is coordinately regulated by stress kinases and the ubiquitin-proteasomal network...
  84. pmc Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai-mediated ubiquitination
    Andrea Hartsock
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, California, United States of America
    PLoS ONE 7:e37476. 2012
    ..Our results indicate that ubiquitination of the JMD inhibits p120-catenin binding, and targets E-cadherin for degradation...
  85. pmc The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome
    Carmela Fusco
    Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    PLoS ONE 7:e40440. 2012
    ..We speculate that when the proteasome activity is impaired, TRIM50 fails to drive its substrates to the proteasome-mediated degradation, and promotes their storage in the aggresome for successive clearance...
  86. pmc Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1
    Stephanie Francois
    Department of Experimental Medicine, University of Milano Bicocca, Monza, Italy
    PLoS ONE 7:e43335. 2012
    ..Taken together, these data shed new light on the molecular mechanism of necdin anti-apoptotic activity in myogenesis...
  87. pmc Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons
    M M Magiera
    Institut de Génétique Moléculaire de Montpellier UMR 5535 CNRS, Montpellier, France
    Cell Death Differ 20:281-92. 2013
    ..As this stabilization of Mcl-1 increased its neuroprotective effect, our data strongly suggest that Trim17-mediated ubiquitination and degradation of Mcl-1 is necessary for initiating neuronal death...
  88. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
    ..These findings establish OTUD7B as a crucial regulator of signal-induced non-canonical NF-κB activation and indicate a mechanism of immune regulation that involves OTUD7B-mediated deubiquitination and stabilization of TRAF3...
  89. doi USP2-45 represses aldosterone mediated responses by decreasing mineralocorticoid receptor availability
    Nourdine Faresse
    Institute of Anatomy, University of Zurich, Zurich, Switzerland
    Cell Physiol Biochem 31:462-72. 2013
    ..This study investigated the role of the aldosterone induced ubiquitin-specific protease USP2-45 on the ubiquitylation state of MR...
  90. pmc Androgen receptor inclusions acquire GRP78/BiP to ameliorate androgen-induced protein misfolding stress in embryonic stem cells
    Y C Yang
    Graduate Institute of Clinical Medical Sciences, Chang Gung University, College of Medicine, Kaohsiung, Taiwan
    Cell Death Dis 4:e607. 2013
    ..These results generate novel insight into how ESCs respond to stress induced by misfolded AR proteins and identify GRP78/BiP as a novel regulator of the AR protein quality control...
  91. pmc Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells
    N Jiang
    Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cell Death Dis 4:e647. 2013
    ..5222, P<0.05). These findings demonstrated that VCP regulates DNA-PKcs degradation and increases the sensitivity of GBM cells to radiation...
  92. ncbi Overexpression of three ubiquitin genes in mouse epidermal tumors is associated with enhanced cellular proliferation and stress
    J S Finch
    Department of Radiation Oncology, University of Arizona Medical School, Tucson 85724
    Cell Growth Differ 3:269-78. 1992
    ..4, 2.8, 6.4, and 7.8 kilobases (kb) were detected by an oligonucleotide specific for a mouse UbC polyubiquitin clone. A 1...
  93. ncbi Expression of polyubiquitin and heat-shock protein 70 genes increases in the later stages of disease progression in scrapie-infected mouse brain
    N Kenward
    Department of Biochemistry, University of Nottingham Medical School, Queen s Medical Centre, England
    J Neurochem 62:1870-7. 1994
    We have shown by northern analyses that the expression of the mouse polyubiquitin C gene is increased severalfold in the brains of mice infected with both the ME7 and 87V strains of scrapie...
  94. ncbi Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials
    T Ishiguro
    Laboratory of Biomedical Research, University of Tokyo, Japan
    Cancer Res 56:875-9. 1996
    ..TI-241 may regulate the expression of various genes as a transcription factor in the complex process of metastasis...
  95. pmc Novel aspects of degradation of T cell receptor subunits from the endoplasmic reticulum (ER) in T cells: importance of oligosaccharide processing, ubiquitination, and proteasome-dependent removal from ER membranes
    M Yang
    Laboratory of Immune Cell Biology, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1152, USA
    J Exp Med 187:835-46. 1998
    ..These findings provide new insights into mechanisms employed to regulate levels of TCRs, and underscore that cells use multiple mechanisms to target proteins from the ER to the cytosol for degradation...
  96. ncbi Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain
    S Miyake
    Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:16619-28. 1999
    ..These results demonstrate that Cbl can negatively regulate PDGFR-dependent biological responses and that this function requires the conserved tyrosine kinase binding domain of Cbl...
  97. ncbi Evolution of the mouse polyubiquitin-C gene
    Andrey A Perelygin
    Department of Biology, Georgia State University, 24 Peachtree Center Avenue, Atlanta, GA 30303, USA
    J Mol Evol 55:202-10. 2002
    ..Here we report the sequences of the polyubiquitin-C (Ubc) genes in two mouse strains...
  98. ncbi Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation
    Chun Yang
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, California 92130, USA
    Mol Cell 21:135-41. 2006
    ..Thus, in contrast to the activation pathway mediated by serine/threonine phosphorylation, tyrosine phosphorylation of Itch plays a negative role in modulating Itch-promoted ubiquitination...
  99. ncbi The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    Lufen Chang
    Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E Duarte Road, KCRB 3009, Duarte, CA 91010, USA
    Cell 124:601-13. 2006
    ..Thus, JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L)...
  100. ncbi Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression
    Lingfei Hou
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 51:441-54. 2006
    ..These findings indicate that the translation, ubiquitination, and proteolysis of FMRP functions as a dynamic regulatory system for controlling synaptic plasticity...
  101. ncbi Phosphorylation-independent ubiquitylation and endocytosis of Fc gammaRIIA
    Patricia Mero
    Molecular and Cellular Biology Research, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada
    J Biol Chem 281:33242-9. 2006
    ..Endocytosis of Fc gammaRIIA is dependent on clathrin but independent of the adaptor protein AP-2. These findings point to a novel mechanism for ubiquitylation and endocytosis of this immunoreceptor...

Research Grants5

  1. The Role of MicroRNA in Hepatocarcinogenesis
    Kalpana Ghoshal; Fiscal Year: 2007
    ..Further, this proposal fits well with the mission/goals set forth by multiple institutes that include NCI, NIDDK and NIAAA n the etiology, prevention and treatment of hepatocellular carcinomas. [unreadable] [unreadable] [unreadable]..
  2. GLUCOCORTICOID ATTENUATED RESPONSE GENES IN INFLAMMATION
    Jeffrey Smith; Fiscal Year: 2001
    ..Genes identified in this search are likely to encode pro-inflammatory mediators that participate in a wide range of inflammatory lung diseases in addition to endotoxemia. ..
  3. RESPONSE TO INJURY IN GAMMAGLUTAMYL CYCLE DEFICIENT MICE
    GEETHA HABIB; Fiscal Year: 2004
    ..4. Only low levels of GSH are needed for development and survival of unstressed mice. These low levels of GSH render mice hypersensitive to chemical injury. ..
  4. FUNCTION OF GAMMA GLUTAMYL LEUKOTRIENASE
    GEETHA HABIB; Fiscal Year: 2005
    ..4. Testing of the hypothesis that LTD4 is the principal cysteinyl LT mediator of bronchial asthma. ..
  5. RIP2 kinase's function in Innate Immunity
    Derek Abbott; Fiscal Year: 2007
    ..This grant application aims to define the preferred peptide phosphorylation sites of RIP2, to map the phosphorylation site of TRAF6 and to identify the physiologic significance of RIP2's phosphorylation of TRAF6. ..