Tyr

Summary

Gene Symbol: Tyr
Description: tyrosinase
Alias: Oca1, albino, skc35, tyrosinase, albino locus protein, monophenol monooxygenase
Species: mouse

Top Publications

  1. ncbi Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7
    M D Potter
    University of Tennessee Oak Ridge Graduate School of Biomedical Sciences 37831 8077, USA
    Mamm Genome 6:70-5. 1995
  2. ncbi trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues
    L Tessarollo
    Molecular Embryology Section, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201
    Development 118:463-75. 1993
  3. pmc Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes
    Alexander C Theos
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust, Cambridge CB2 2XY, United Kingdom
    Mol Biol Cell 16:5356-72. 2005
  4. ncbi Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling
    B A Taylor
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609 1500, USA
    Genomics 34:389-98. 1996
  5. doi Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling
    Likun Li
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 68:434-43. 2008
  6. ncbi Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)
    C A Kozak
    Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 25:66-72. 1995
  7. pmc Expression of the mouse tyrosinase gene during embryonic development: recapitulation of the temporal regulation in transgenic mice
    F Beermann
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Proc Natl Acad Sci U S A 89:2809-13. 1992
  8. ncbi A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85
    S Shibahara
    Department of Applied Physiology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Biochem 189:455-61. 1990
  9. pmc Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice
    F Beermann
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    EMBO J 9:2819-26. 1990
  10. pmc Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant
    I J Jackson
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    Proc Natl Acad Sci U S A 87:7010-4. 1990

Research Grants

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
  2. AXON TARGET INTERACTIONS IN THE DEVELOPING CEREBELLUM
    Carol Mason; Fiscal Year: 2002
  3. CATECHOLAMINES AND DEVELOPMENT
    Suzanne Roffler Tarlov; Fiscal Year: 2002
  4. Albinism: Defects in Tyrosinase, Amines, or Melanin
    Suzanne Roffler Tarlov; Fiscal Year: 2005
  5. Mutagenesis of the Mammalian Imprinting Process(es)
    Eugene Rinchik; Fiscal Year: 2002
  6. COCHLEAR VULNERABILITY/REACTIVE OXYGEN SPECIES
    KEVIN OHLEMILLER; Fiscal Year: 2003
  7. REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTS
    Gregory Barsh; Fiscal Year: 2003
  8. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2003
  9. TRANSMISSION ELECTRON MICROSCOPE
    Martin Katz; Fiscal Year: 2006
  10. Genetics of Dark Skin in Mice
    Gregory Barsh; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications129 found, 100 shown here

  1. ncbi Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7
    M D Potter
    University of Tennessee Oak Ridge Graduate School of Biomedical Sciences 37831 8077, USA
    Mamm Genome 6:70-5. 1995
    ..We report mapping of the fit1 locus, by trans-complementation crosses to mice carrying deletions of the albino (c) locus in Chromosome (Chr) 7, to a subregion of the c-deletion complex within the Mod2-sh1 interval...
  2. ncbi trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues
    L Tessarollo
    Molecular Embryology Section, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702 1201
    Development 118:463-75. 1993
    ..Alignment with available chromosomal maps identify possible linkage between the Trk genes and known neurological mutations...
  3. pmc Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes
    Alexander C Theos
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust, Cambridge CB2 2XY, United Kingdom
    Mol Biol Cell 16:5356-72. 2005
    ..Here, we show that AP-3 and AP-1 function independently in sorting of the melanocyte-specific protein tyrosinase from endosomes to the melanosome, a specialized lysosome-related organelle distinguishable from lysosomes...
  4. ncbi Detection of obesity QTLs on mouse chromosomes 1 and 7 by selective DNA pooling
    B A Taylor
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine, 04609 1500, USA
    Genomics 34:389-98. 1996
    ..The possible relationships between these QTLs and previously described obesity QTLs, major obesity mutations, and candidate genes are discussed...
  5. doi Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling
    Likun Li
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 68:434-43. 2008
    ..Thus, our results identify GLIPR1 as a proapoptotic tumor suppressor acting through the ROS-JNK pathway and support the therapeutic potential for this protein...
  6. ncbi Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)
    C A Kozak
    Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 25:66-72. 1995
    ..Western blotting indicates that despite high sequence conservation in human and mouse, the TARBP2 protein differs in apparent size in primate and rodent cells...
  7. pmc Expression of the mouse tyrosinase gene during embryonic development: recapitulation of the temporal regulation in transgenic mice
    F Beermann
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Proc Natl Acad Sci U S A 89:2809-13. 1992
    ..b>Tyrosinase (monophenol, L-dopa:oxygen oxidoreductase, EC 1.14.18...
  8. ncbi A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85
    S Shibahara
    Department of Applied Physiology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Biochem 189:455-61. 1990
    ..In order to study the molecular basis of albinism, we have cloned and characterized the tyrosinase gene of BALB/c mice (c/c)...
  9. pmc Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice
    F Beermann
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    EMBO J 9:2819-26. 1990
    The c-locus of the mouse is thought to encode tyrosinase, the key enzyme for melanin synthesis in melanocytes of the skin and the eye...
  10. pmc Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant
    I J Jackson
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    Proc Natl Acad Sci U S A 87:7010-4. 1990
    ..We sequenced a part of the tyrosinase gene, encompassing a candidate mutation, from wild-type, albino, and revertant cell DNAs...
  11. pmc Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice
    T Yokoyama
    Howard Hughes Medical Institute, Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Nucleic Acids Res 18:7293-8. 1990
    Albinism, due to a lack of melanin pigment, is one of the oldest known mutations in mice. Tyrosinase (monophenol oxygenase, EC 1.14.18...
  12. ncbi Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene
    B S Kwon
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202 5120
    J Invest Dermatol 93:589-94. 1989
    Using a human tyrosinase cDNA probe, we have isolated mouse tyrosinase genomic clones and used them to map the mouse tyrosinase locus and to analyze the promoter sequence of the tyrosinase gene...
  13. pmc A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice
    R Ganss
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    EMBO J 13:3083-93. 1994
    The tyrosinase gene encodes the key enzyme of melanin production and is tightly regulated during development...
  14. ncbi A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice
    A Schedl
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Nature 362:258-61. 1993
    ..Here we report the transfer of a 250 kilobase YAC covering the mouse tyrosinase gene into mice by pronuclear injection of gel-purified YAC DNA...
  15. ncbi Tyrosinase and related proteins in mammalian pigmentation
    V del Marmol
    LOCE, Institut J Bordet, Universite Libre de Bruxelles, Belgium
    FEBS Lett 381:165-8. 1996
    b>Tyrosinase is the key enzyme in pigment synthesis, initiating a cascade of reactions which convert the amino acid tyrosine to the melanin biopolymer...
  16. ncbi Tyrosinase, the key enzyme in melanin synthesis, is expressed in murine brain
    K Tief
    Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland
    Eur J Biochem 241:12-6. 1996
    b>Tyrosinase is one of the key enzymes in mammalian melanin synthesis. The pigment is produced in two different cell types: the pigmented epithelial cell of the retina, and the melanocyte, a cell of neural-crest origin...
  17. ncbi Tyrosinase is a new marker for cell populations in the mouse neural tube
    K Tief
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges, Switzerland
    Dev Dyn 205:445-56. 1996
    b>Tyrosinase, the key enzyme in melanin synthesis, is expressed in pigment cells derived from both neural crest and neuroectoderm...
  18. ncbi Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism
    N Le Fur
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genomics 37:245-8. 1996
    The c2j albino mutation at the mouse tyrosinase locus arose spontaneously in the C57BL/6 inbred strain and causes complete absence of melanin synthesis, as does the "classical" c mutation of long-established albino inbred strains...
  19. pmc A locus control region at -12 kb of the tyrosinase gene
    L Montoliu
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    EMBO J 15:6026-34. 1996
    We have shown previously that the tyrosinase gene encompassed in a 250 kb yeast artificial chromosome (YAC) is expressed faithfully in transgenic mice...
  20. ncbi Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits
    G Jeffery
    Institute of Ophthalmology, University College London, UK
    Brain Res Dev Brain Res 99:95-102. 1997
    ..It has been demonstrated using transgenic mice that the chiasmatic abnormality is controlled by the tyrosinase gene, which is the key enzyme in melanin synthesis...
  21. pmc Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11
    P Liu
    Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 150:1155-68. 1998
    ..A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality...
  22. ncbi Tyrosinase stabilization by Tyrp1 (the brown locus protein)
    T Kobayashi
    Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda Maryland 20892, USA
    J Biol Chem 273:31801-5. 1998
    ..The Tyr/albino locus, in which mutations cause a lack of pigmentation, encodes tyrosinase (Tyr), the critical and rate-limiting melanogenic enzyme...
  23. ncbi Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase
    M Rios
    Departments of Neuroscience and Anatomy and Cell Biology, Tufts University Medical School, Boston, Massachusetts 02111, USA
    J Neurosci 19:3519-26. 1999
    ..To ascertain the source of the catecholamine, we examined postnatal TH-null albino mice that lack tyrosinase, another enzyme that converts tyrosine to L-Dopa but does so during melanin synthesis...
  24. pmc Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy
    T A Colella
    Department of Microbiology and the Beirne Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia 22908, USA
    J Exp Med 191:1221-32. 2000
    The human tyrosinase-derived peptide YMDGTMSQV is presented on the surface of human histocompatibility leukocyte antigen (HLA)-A*0201(+) melanomas and has been suggested to be a tumor antigen despite the fact that tyrosinase is also ..
  25. ncbi Fmr1 knockout mouse has a distinctive strain-specific learning impairment
    C Dobkin
    Department of Genetics, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, NY 10314, Staten Island, USA
    Neuroscience 100:423-9. 2000
    ..The strain dependence may model the influence of genetic background in the human Fragile X syndrome...
  26. ncbi Otx genes are required for tissue specification in the developing eye
    J R Martinez-Morales
    Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 128:2019-30. 2001
    ..vesicle infolding was severely altered and the expression of pigment epithelium-specific genes, such as Mitf or tyrosinase, was lost...
  27. ncbi Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines
    K Schuster-Gossler
    Medizinische Hochschule Hannover, Germany
    Biotechniques 31:1022-4, 1026. 2001
    ..Our data support the use of the coisogenic albino host strain, c2J, for the generation of germline-competent chimeric mice when using B6 ES cells.
  28. pmc Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina
    Rivka A Rachel
    Center for Neurobiology and Behavior, Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 22:4249-63. 2002
    In albino mammals, lack of pigment in the retinal pigment epithelium is associated with retinal defects, including poor visual acuity from a photoreceptor deficit in the central retina and poor depth perception from a decrease in ..
  29. ncbi Modification of ocular defects in mouse developmental glaucoma models by tyrosinase
    Richard T Libby
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Science 299:1578-81. 2003
    ..Using Cyp1b1-/- mice, we identified the tyrosinase gene (Tyr) as a modifier of the drainage structure phenotype, with Tyr deficiency increasing the magnitude of ..
  30. ncbi Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4
    Gertrude E Costin
    Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 116:3203-12. 2003
    ..forms of OCA have been previously characterized, each resulting from the aberrant processing and/or sorting of tyrosinase, the enzyme critical to pigment production in mammals...
  31. ncbi Tyrosinase: a developmentally specific major determinant of peripheral dopamine
    Graeme Eisenhofer
    Section on Clinical Neurocardiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr MSC 1620, Bethesda, MD 20892 1620, USA
    FASEB J 17:1248-55. 2003
    ..be formed by two enzymes: tyrosine hydroxylase (TH) in catecholamine-producing neurons and chromaffin cells and tyrosinase in melanocytes. In this study we examined whether tyrosinase contributes to production of dopamine...
  32. pmc Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity
    Patricia Giraldo
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia CNB CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
    Nucleic Acids Res 31:6290-305. 2003
    ..We have analysed the mouse tyrosinase LCR functions, in vitro, in cell lines and, in vivo, in transgenic mice and flies. The LCR-core (2...
  33. ncbi Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
    D Jonathan Horsford
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 132:177-87. 2005
    ..We demonstrate that the repression of Mitf by FGF is Chx10 dependent, indicating that FGF, Chx10 and Mitf are components of a pathway that determines and maintains the identity of the NR...
  34. ncbi Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
    John A D'Orazio
    Melanoma Program, Dana Farber Cancer Institute and Children s Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 443:340-4. 2006
    ..These data emphasize the essential role of intercellular MSH signalling in the tanning response, and suggest a clinical strategy for topical small-molecule manipulation of pigmentation...
  35. ncbi Distinct distal regulatory elements control tyrosinase expression in melanocytes and the retinal pigment epithelium
    Fabien Murisier
    Swiss Institute for Experimental Cancer Research, National Center of Competence in Research, Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Dev Biol 303:838-47. 2007
    ..The pigmentation gene tyrosinase is expressed in all pigment cells but differentially regulated in melanocytes and RPE...
  36. ncbi Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes
    Lisa A Nichols
    Department of Microbiology and Carter Immunology Center, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Immunol 179:993-1003. 2007
    ..We have used a newly generated TCR-transgenic mouse to establish the basis of tolerance to one such Ag from tyrosinase. Despite expression of tyrosinase transcripts in the thymus, central deletion does not shape the tyrosinase-..
  37. pmc Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:1169-78. 2008
    ....
  38. pmc Eye-specific projections of retinogeniculate axons are altered in albino mice
    Alexandra Rebsam
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Neurosci 32:4821-6. 2012
    ..affects eye-specific retinogeniculate targeting in albino mice using the C57BL/6 Tyr(c-2J/c-2J) strain, in which tyrosinase, necessary for melanogenesis, is mutated...
  39. pmc A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development
    Kapil Bharti
    Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 8:e1002757. 2012
    ..The results suggest that careful manipulation of the Pax6 regulatory circuit may facilitate the generation of retinal and pigment epithelium cells from embryonic or induced pluripotent stem cells...
  40. pmc Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells
    Eric F Tewalt
    Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Blood 120:4772-82. 2012
    ..Rescue of tyrosinase-specific T(CD8) by interference with PD-1 or provision of costimulation results in autoimmune vitiligo, ..
  41. pmc Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain
    Edward Ryder
    The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    Genesis 51:523-8. 2013
    We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic)...
  42. ncbi The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7
    M A Pritchard
    Department of Cytogenetics and Molecular Genetics, Adelaide Children s Hospital, Australia
    Genomics 10:801-6. 1991
    ..Interestingly, the position on human chromosome 16 suggests that the IL4R may be a candidate for rearrangements, as 12;16 translocations are often associated with myxoid liposarcomas...
  43. ncbi Mosaicism of tyrosinase-locus transcription and chromatin structure in dark vs. light melanocyte clones of homozygous chinchilla-mottled mice
    S Porter
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
    Dev Genet 12:393-402. 1991
    The chinchilla-mottled (cm) mutation at the mouse tyrosinase-encoding locus leads to a transversely striped pattern of dark- and light-grey coat colors in homozygotes...
  44. pmc Intraocular pressure in genetically distinct mice: an update and strain survey
    O V Savinova
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    BMC Genet 2:12. 2001
    ....
  45. ncbi The ocular albinism type 1 (OA1) gene controls melanosome maturation and size
    Katia Cortese
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    Invest Ophthalmol Vis Sci 46:4358-64. 2005
    The authors took advantage of the Oa1 mutant mouse in combination with other albinism mouse models (i.e., Tyrosinase and membrane-associated transporter protein [Matp]) to study the function of Oa1, the gene mutated in ocular albinism ..
  46. ncbi Molecular analysis of viable spontaneous and radiation-induced albino (c)-locus mutations in the mouse
    E M Rinchik
    Biology Division, Oak Ridge National Laboratory, TN 37831 8077
    Mutat Res 286:199-207. 1993
    ..and with probes derived from the closely linked proviral integration sites Pmv-31 and Emv-23, which flank the tyrosinase gene on the proximal and distal sides, respectively...
  47. pmc Murine albino-deletion complex: high-resolution microsatellite map and genetically anchored YAC framework map
    B A Rikke
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Genetics 147:787-99. 1997
    The murine albino-deletion complex developed as part of the Oak Ridge specific-locus test covers 6-11 cM of chromosome 7...
  48. ncbi Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map
    H Yoshitomi
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3, Tokodai, Tsukuba, Ibaraki 300 2635, Japan
    Gene 215:77-84. 1998
    ..As Solanes et al. reported that both human UCP2 and UCP3 genes are assigned to chromosome 11q13, the region where the mouse Ucp2 and Ucp3 are localized is syntenic to human chromosome 11q13...
  49. ncbi Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes
    N G Copeland
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genomics 13:1356-8. 1992
    ..These results refine previous localizations by in situ hybridization as well as confirm and extend known regions of homology between mouse and human chromosomes...
  50. ncbi Molecular bases of tyrosinase-negative oculocutaneous albinism: a single base insertion or a missense point mutation in the tyrosinase gene
    Y Tomita
    Department of Dermatology, Thoku University School of Medicine, Sendai, Japan
    Pigment Cell Res . 1992
    We have identified two different mutations in the tyrosinase genes of Japanese patients with tyrosinase-negative oculocutaneous albinism (OCA)...
  51. ncbi Genomic mapping within the albino-deletion complex using individual early postimplantation mouse embryos
    S K Sharan
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106
    Mamm Genome 3:79-83. 1992
    ..Using this procedure, we have been able to redefine the distal limits of the region of Chromosome (Chr) 7 containing a gene (eed) needed for development of the embryonic ectoderm...
  52. ncbi Genetic linkage analysis and homology relationships of genes located on human chromosome 11q
    P Charmley
    Department of Microbiology and Immunology, University of California, Los Angeles 90024
    Genomics 10:608-17. 1991
    ..Our map includes the genes for CD20, tyrosinase, progesterone receptor, stromelysin, collagenase, N-CAM, dopamine-D2 receptor, apolipoproteins AI-CIII-AIV, CD3-..
  53. ncbi Microclones derived from the mouse chromosome 7 D-E bands map within the proximal region of the c14CoS deletion in albino mutant mice
    R R Tönjes
    Department of Cell Biology, Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Federal Republic of Germany
    Genomics 10:686-91. 1991
    A group of radiation-induced perinatal-lethal deletions that include the albino (c) locus on mouse chromosome 7 causes failure of expression of various hepatocyte-specific genes when homozygous (S...
  54. ncbi Multiple alternatively spliced transcripts of the mouse tyrosinase-encoding gene
    S Porter
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
    Gene 97:277-82. 1991
    We have isolated and characterized tyrosinase-specific cDNAs from wild-type mouse skin, to provide a basis for the structural and functional analysis of mutations at the mouse tyrosinase-encoding (Tyr) locus...
  55. ncbi Axonal abnormalities in cerebellar Purkinje cells of the 'hyperspiny Purkinje cell' mutant mouse
    C Sotelo
    Laboratoire de Neuromorphologie, INSERM U 106, Hopital de la Salpetriere, Paris, France
    J Neurocytol 19:737-55. 1990
    ..Therefore, the hpc mutation offers a valuable tool to analyse some of the genetic factors involved in the differentiation and maintenance of cerebellar Purkinje cells...
  56. ncbi Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression
    B S Kwon
    Molecular Genetics, Guthrie Research Institute, Sayre, PA 18840 1692
    Biochem Biophys Res Commun 153:1301-9. 1988
    Using human tyrosinase cDNA as a probe, a mouse tyrosinase cDNA clone representing approximately 75% of the tyrosinase coding region and a mouse genomic clone which includes the tyrosinase 5' coding sequences were isolated: nucleotide and ..
  57. ncbi Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse
    S Kerscher
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire, OX11 ORD, United Kingdom
    Genomics 36:17-21. 1996
    ..While there are no obvious candidate genes in the vicinity of the Ccw, Npp, and Opj mutations, To3 lies remarkably close to the recently mapped Lim2 locus, which encodes lens intrinsic membrane protein 2, also called MP19...
  58. pmc Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death
    N Hagiwara
    Department of Pediatrics, The University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Proc Natl Acad Sci U S A 97:4180-5. 2000
    ..The p(100H) mutant is thus a useful animal model in the elucidation of myopathies at the molecular level...
  59. ncbi Expression pattern of the ocular albinism type 1 (Oa1) gene in the murine retinal pigment epithelium
    E M Surace
    Telethon Institute of Genetics and Medicine and the Universitá Vita e Salute, San Raffaele, Milan, Italy
    Invest Ophthalmol Vis Sci 41:4333-7. 2000
    ..The localization of Oa1 mRNA was studied and compared with the expression of other genes involved in melanosomal biogenesis...
  60. ncbi Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin
    M L Lamoreux
    Department of Veterinary Pathobiology, Texas A and M University, College Station, USA
    Pigment Cell Res 14:23-31. 2001
    ..e., the albino (C) locus that encodes tyrosinase, the slaty (Slt) locus that encodes tyrosinase-related protein 2 (TRP2 also known as dopachrome tautomerase, DCT)..
  61. pmc Mutation of melanosome protein RAB38 in chocolate mice
    Stacie K Loftus
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:4471-6. 2002
    ..Rab38(cht)/Rab38(cht) mice exhibit a brown coat similar in color to mice with a mutation in tyrosinase-related protein 1 (Tyrp1), a mouse model for oculocutaneous albinism...
  62. ncbi "Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells
    Jing Chen
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609 1500, USA
    Mamm Genome 16:775-83. 2005
    ..agouti stock already containing approximately 50% NOD genome, was used as the donor source of a wild-type CBA tyrosinase allele...
  63. ncbi Gene expression profiles of homogentisate-treated Fah-/- Hpd-/-mice using DNA microarrays
    Yasuhiko Tanaka
    Department of Pediatrics, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Mol Genet Metab 89:203-9. 2006
    ..We found that numerous genes, including amino acid metabolism and apoptosis related genes, were up- or down-regulated at the onset of liver failure. These findings are useful in understanding the pathogenesis of hereditary tyrosinemia...
  64. pmc Iris phenotypes and pigment dispersion caused by genes influencing pigmentation
    Michael G Anderson
    Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA
    Pigment Cell Melanoma Res 21:565-78. 2008
    ..Combined, these findings illustrate the utility of studying iris phenotypes as a means of discovering new pathways, and re-linking old ones, to processes of pigmented cells in health and disease...
  65. pmc Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence
    Daniel Gibbs
    Departments of Pharmacology, UCSD School of Medicine, La Jolla, California, USA
    Invest Ophthalmol Vis Sci 50:4386-93. 2009
    ..This study was undertaken to identify an imaging method for noninvasively monitoring the RPE component of the USH1B disease...
  66. pmc An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background
    Devarati Mitra
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nature 491:449-53. 2012
    ..To investigate the mechanism of ultraviolet-radiation-independent carcinogenesis, we introduced an albino allele, which ablates all pigment production on the Mc1r(e/e) background...
  67. pmc All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities
    Siddharth Jhunjhunwala
    3 720 Rutland Ave, Room 755A, Baltimore, MD 21205, USA or University of Pittsburgh, 3700 O Hara St, 440 Benedum Hall, Pittsburgh, PA 15261, USA E mail Twitter
    J Leukoc Biol 94:981-9. 2013
    ..This difference in migratory activity significantly affects the therapeutic capacity of each subset in a mouse model of colitis. We also describe the characteristics of iTreg generated in the presence of TGF-β, RA, and rapa. ..
  68. doi Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation
    Young Mi Ha
    College of Pharmacy, Pusan National University, Kumjeong gu, Busan 609 735, Republic of Korea
    Biochim Biophys Acta 1810:612-9. 2011
    Many tyrosinase inhibitors find application in cosmetics and pharmaceutical products for the prevention of the overproduction of melanin in the epidermis...
  69. pmc In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis
    Inés Martínez-Corral
    Biotechnology Programme, Spanish National Cancer Research Centre, CNIO, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 109:6223-8. 2012
    ..This is the first reporter mouse model for luminescence imaging of lymphangiogenesis. It should provide an important tool for studying the involvement of lymphangiogenesis in pathological processes...
  70. pmc NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche
    Chiung Ying Chang
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nature 495:98-102. 2013
    ..Our findings reveal how melanocyte and hair follicle stem cell behaviours maintain reliance upon cooperative factors within the niche, and how this can be uncoupled in injury, stress and disease states...
  71. ncbi [Genetic analysis of interspecific crosses Mus musculus L. x Mus spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and Es-14 with Mod-1 on chromosome 9]
    F Bonhomme
    C R Seances Acad Sci D 289:545-8. 1979
    ..Linkage of ES-14 with Mod-1 on chromosome 9 and that of Adh-1 with Amy-1 on chromosome 3 are shown. The following order centromere/Car-2/Amy-1 is tentatively proposed for these loci on chromosome 3...
  72. pmc Assignment of genes to regions of mouse chromosomes
    E M Eicher
    Proc Natl Acad Sci U S A 75:946-50. 1978
    ....
  73. ncbi Mouse albino-deletions: from genetics to genes in development
    B Holdener-Kenny
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955
    Bioessays 14:831-9. 1992
    Six essential genes located near the mouse albino locus have been identified as required during specific periods of development...
  74. ncbi Molecular structure of the tyrosinase gene
    T Takeuchi
    Biological Institute, Tohoku University, Sendai, Japan
    Pigment Cell Res . 1992
  75. ncbi Localization of 11q13 loci with respect to regional chromosomal breakpoints
    P Szepetowski
    LGMCH, CNRS URA 1462, Nice, France
    Genomics 12:738-44. 1992
    ....
  76. ncbi Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice
    S Ruppert
    Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg
    Genes Dev 6:1430-43. 1992
    Mice homozygous for albino deletions encompassing the locus alf/hsdr-1 die shortly after birth...
  77. ncbi The monoclonal antibodies TMH-1 and TMH-2 specifically bind to a protein encoded at the murine b-locus, not to the authentic tyrosinase encoded at the c-locus
    Y Tomita
    Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
    J Invest Dermatol 96:500-4. 1991
    ..and TMH-3, were previously reported by Tomita et al to produce monoclonal antibodies against murine and human T4-tyrosinase localized in melanosome for the formation of melanin pigment...
  78. pmc Immune responses in newly developed short-lived SAM mice. IV. Chromosomal location of a gene controlling defective helper T-cell activity
    K Hanada
    Department of Senescence Biology, Kyoto University, Japan
    Immunology 74:160-4. 1991
    ..These results suggest that one of the genes controlling the hypo-responsiveness of SAM-P/1 mice is linked to both Gpi-1 and c loci and that it locates at a more proximal site on Chr.7...
  79. ncbi Microdissection and microcloning from the proximal region of mouse chromosome 7: isolation of clones genetically linked to the pudgy locus
    A J Greenfield
    Department of Biochemistry, St Mary s Hospital Medical School, University of London, United Kingdom
    Genomics 1:153-8. 1987
    ..Several important loci map to this area, including the albino locus (c), pink-eye dilution (p), and the developmental mutant, pudgy (pu)...
  80. ncbi Survey of int region DNA rearrangements in C3H and BALB/cfC3H mouse mammary tumor system
    V K Pathak
    J Natl Cancer Inst 78:327-31. 1987
    ..However, the int-1 rearrangement maintained in 1 BALB/cfC3H HPO line through 11 transplant generations suggests that the int-1 rearrangement is neither sufficient nor necessary for progression to mouse mammary carcinoma...
  81. ncbi Aldehyde reductase isozymes in the mouse: evidence for two new loci and localization of Ahr-3 on chromosome 7
    P B Mather
    Biochem Genet 23:483-96. 1985
    ..Genet. 20:1067, 1982)], hexonate dehydrogenase (AHR-2), and alcohol dehydrogenase A2 in terms of their differential substrate, coenzyme, and inhibitor specificities...
  82. pmc A defective ecotropic provirus closely linked to the albino locus
    J Silver
    J Virol 55:494-6. 1985
    A congenic mouse strain (NFS.C) carrying the albino region of chromosome 7 from strain C58/Lw on an ecotropic virus-negative NFS background inherited a noninducible but apparently full-size provirus reactive with an ecotropic virus-..
  83. ncbi Genetic mapping of a murine leukemia virus-inducing locus of AKR mice
    W P Rowe
    Science 178:860-2. 1972
    ..This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-1 locus...
  84. ncbi Nijmegen waltzer--a new neurological mutant in the mouse
    J H van Abeelen
    Genet Res 10:117-8. 1967
  85. ncbi The effect of temperature on tyrosinase activity in Himalayan mouse skin
    S H Kidson
    J Exp Zool 215:91-7. 1981
    The tyrosinase activity of Himalayan mouse skin homogenates was measured over a range of temperatures using two sensitive radiometric assay--namely, (1) the measurement of 14C-tyrosine incorporation into melanin, and (2) the measurement ..
  86. ncbi Prt-4 and Prt-5: new constituents of a gene cluster on chromosome 7 coding for esterproteases in the submandibular gland of the house mouse (Mus musculus)
    J Otto
    Biochem Genet 19:431-44. 1981
    ..From a four-point-cross, the gene order Gpi-1-(Tam-1, Prt-4, Prt-5)-c is suggested. Thus a gene cluster was shown to exist on chromosome 7 coding for esterproteases, all of which are controlled by testosterone...
  87. pmc Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression
    S J Orlow
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York 10016, USA
    Proc Natl Acad Sci U S A 92:10152-6. 1995
    Cutaneous melanomas of Tyr-SV40E transgenic mice (mice whose transgene consists of the tyrosinase promoter fused to the coding regions of simian virus 40 early genes) strikingly resemble human melanomas in their development and ..
  88. ncbi Physical localization of eed: a region of mouse chromosome 7 required for gastrulation
    B C Holdener
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Genomics 27:447-56. 1995
    In the mouse, the embryonic ectoderm development (eed) region is defined by deletions encompassing the albino (c) locus of chromosome 7. The region is located 1-2 cM distal to the c locus and was of undetermined size...
  89. ncbi Localization of a novel chromosome 7 locus that suppresses development of N-Methyl-N-nitrosourea-induced murine thymic lymphomas
    J M Angel
    University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957
    Mol Carcinog 7:151-6. 1993
    ..a significant linkage between high tumor incidence and homozygous inheritance of AKR alleles at the albino (tyrosinase) and Hbb loci...
  90. pmc A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing
    J F Martin
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Mol Cell Biol 14:1647-56. 1994
    ..The complexity of the MEF2 family of regulatory proteins provides the potential for fine-tuning of transcriptional responses as a consequence of combinatorial interactions among multiple MEF2 isoforms encoded by the four Mef2 genes...
  91. ncbi Deletion mapping of the chocolate (cht) locus within the Fes-Hbb region of mouse chromosome 7
    M D Potter
    University of Tennessee, Oak Ridge Graduate School of Biomedical Sciences
    Mamm Genome 4:46-8. 1993
  92. ncbi Functional analysis of the tyrosinase gene and brown-locus protein gene promoters
    S Shibahara
    Department of Applied Physiology and Molecular Biology, Tohoku University School of Medicine, Miyagi, Japan
    J Invest Dermatol 100:146S-149S. 1993
    b>Tyrosinase is a rate-limiting enzyme of melanin biosynthesis and the brown (b)-locus protein is responsible for the formation of black melanin rather than brown...
  93. ncbi Retinal axon divergence in the optic chiasm: midline cells are unaffected by the albino mutation
    R C Marcus
    Department of Pathology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York 10032, USA
    Development 122:859-68. 1996
    The visual pathway in albino animals is abnormal in that there is a smaller number of ipsilaterally projecting retinal ganglion cells. There are two possible sites of gene action that could result in such a defect...
  94. ncbi Production of POMC, CRH-R1, MC1, and MC2 receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL/6 mouse skin
    G Ermak
    Department of Pathology and Laboratory Medicine, Albany Medical College, New York 12208, USA
    J Invest Dermatol 108:160-5. 1997
    ..This production was associated with anagen-dependent expression of the tyrosinase gene and enzyme activity. In contrast, the production of 4.5- and 2...
  95. ncbi Spontaneous mutations in SELH/Bc mice due to insertions of early transposons: molecular characterization of null alleles at the nude and albino loci
    M Hofmann
    Department of Developmental Immunology, Max Planck Institute for Immunology, Freiburg, Germany
    Genomics 52:107-9. 1998
  96. ncbi Cis-acting regulation of splenic Art2 gene expression in inbred mouse strains
    D F Sardinha
    Department of Pathology, University of Connecticut Health Center, Department of Pathology MC 3105, 263 Farmington Avenue, Farmington, CT 06030 3105, USA
    Immunogenetics 49:700-3. 1999
  97. ncbi Identification and characterization of a melanocyte-specific novel 65-kDa peripheral membrane protein
    P Samaraweera
    Department of Dermatology, New York University School of Medicine, New York, NY, USA
    Eur J Biochem 266:924-34. 1999
    ..The protein was also detected in melanocytes cultured from albino mice, but absent in cultured mouse cell lines not of melanocyte origin...
  98. ncbi Tyrosinase gene expression in zebrafish embryos
    E Camp
    Department of Molecular Biosciences Genetics, University of Adelaide, 5005 Adelaide, Australia
    Dev Genes Evol 211:150-3. 2001
    The enzyme tyrosinase is required for the conversion of tyrosine into the pigment melanin. Thus, tyrosinase gene expression is a useful marker for studying the differentiation of melanin-expressing cells during embryogenesis...
  99. ncbi Localization of a recessive juvenile cataract mutation to proximal chromosome 7 in mice
    E J Cargill
    Department of Animal Science, University of Nebraska, Lincoln, Nebr 68583 0908, USA
    Hum Hered 52:77-82. 2001
    ..To localize the chromosomal position of a novel cataract mutation (juvenile recessive cataract; jrc) in mice...
  100. ncbi Mapping quantitative trait loci for circadian behavioral rhythms in SMXA recombinant inbred strains
    T Suzuki
    Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Japan
    Behav Genet 30:447-53. 2000
    ..The provisional QTLs detected in the present study might be useful for understanding the complex mechanism regulating circadian behaviors...

Research Grants14

  1. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  2. AXON TARGET INTERACTIONS IN THE DEVELOPING CEREBELLUM
    Carol Mason; Fiscal Year: 2002
    ....
  3. CATECHOLAMINES AND DEVELOPMENT
    Suzanne Roffler Tarlov; Fiscal Year: 2002
    ..and that (2) catecholamines are made in the absence of tyrosine hydroxylase (TH) through the activity of tyrosinase, the enzyme that catalyzes the synthesis of melanin pigments...
  4. Albinism: Defects in Tyrosinase, Amines, or Melanin
    Suzanne Roffler Tarlov; Fiscal Year: 2005
    This proposal requests funding for examination of the hypotheses that (1) tyrosinase activity in the embryonic eye results in the formation of developmental signals, that (2) these signals, perhaps amines, direct the generation of ..
  5. Mutagenesis of the Mammalian Imprinting Process(es)
    Eugene Rinchik; Fiscal Year: 2002
    ..abstract_text> ..
  6. COCHLEAR VULNERABILITY/REACTIVE OXYGEN SPECIES
    KEVIN OHLEMILLER; Fiscal Year: 2003
    ..Our experiments will establish how well the dynamics of ROS production predict cochlear injury, and whether progressive deafness genes may impair cochlear ROS regulation. ..
  7. REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTS
    Gregory Barsh; Fiscal Year: 2003
    ..abstract_text> ..
  8. NEURONAL DEGENERATION HEREDITARY CEROID-LIPOFUSCINOSIS
    Martin Katz; Fiscal Year: 2003
    ....
  9. TRANSMISSION ELECTRON MICROSCOPE
    Martin Katz; Fiscal Year: 2006
    ..Broadening the user base will help make the cost per user of maintaining the instrument as low as possible. [unreadable] [unreadable]..
  10. Genetics of Dark Skin in Mice
    Gregory Barsh; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. Attractin and Mahoganoid in Spongy Neurodegeneration
    Gregory Barsh; Fiscal Year: 2007
    ..Investigating the biochemical, cellular, and genetic relationships between Atrn, Mahoganoid, and PrP is likely to provide general insight into the pathogenesis of spongy degeneration. [unreadable] [unreadable]..
  12. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2007
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  13. Gene Modifiers of Retinal Degeneration
    HENRY DANCIGER; Fiscal Year: 2009
    ..This would make therapeutic approaches simpler. ..
  14. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2009
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..