Trpm5

Summary

Gene Symbol: Trpm5
Description: transient receptor potential cation channel, subfamily M, member 5
Alias: 9430099A16Rik, LTrpC-5, Ltrpc5, Mtr1, transient receptor potential cation channel subfamily M member 5, MLSN1- and TRP-related gene 1 protein, long transient receptor potential channel 5, long transient receptor potential-related channel 5
Species: mouse

Top Publications

  1. doi Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne, Switzerland
    J Neurosci 29:2654-62. 2009
  2. ncbi TRPM5 and taste transduction
    E R Liman
    University of Southern California, 3641 Watt Way, Los Angeles, CA 90089, USA
    Handb Exp Pharmacol . 2007
  3. ncbi TRPM5-expressing solitary chemosensory cells respond to odorous irritants
    Weihong Lin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    J Neurophysiol 99:1451-60. 2008
  4. pmc Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25
    Tod R Clapp
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    BMC Biol 4:7. 2006
  5. doi Food reward in the absence of taste receptor signaling
    Ivan E de Araujo
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 57:930-41. 2008
  6. ncbi Trpm5 null mice respond to bitter, sweet, and umami compounds
    Sami Damak
    Department of Neuroscience, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Chem Senses 31:253-64. 2006
  7. ncbi Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
    Karel Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 438:1022-5. 2005
  8. pmc Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals
    Weihong Lin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Proc Natl Acad Sci U S A 104:2471-6. 2007
  9. pmc TRPM5-expressing microvillous cells in the main olfactory epithelium
    Weihong Lin
    Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    BMC Neurosci 9:114. 2008
  10. pmc Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5
    Dan Liu
    Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 100:15160-5. 2003

Research Grants

  1. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
  2. Putative pheromones in the main olfactory system
    Weihong Lin; Fiscal Year: 2007
  3. Sensory Transduction in the Vomeronasal System
    Emily Liman; Fiscal Year: 2005

Scientific Experts

  • A Sclafani
  • K Talavera
  • Weihong Lin
  • Liliana Minichiello
  • Emily Liman
  • Kunitoshi Uchida
  • Ichiro Matsumoto
  • John A Thompson
  • Matthew Bjerknes
  • John I Glendinning
  • Silke Kaske
  • Ivan E de Araujo
  • Tod R Clapp
  • T Enklaar
  • Chihiro Hisatsune
  • Yuri A Blednov
  • Celine E Riera
  • Robert F Margolskee
  • Keiko Yasumatsu
  • George A Kyriazis
  • Zaza Kokrashvili
  • Yuzo Ninomiya
  • Bhavik P Shah
  • Marco Tizzano
  • Pin Liu
  • Tatsuya Ogura
  • Rudi Vennekens
  • Minqing Rong
  • Dan Liu
  • Cristian A Perez
  • Yugo Nishiguchi
  • Michael R Howitt
  • Junji Hirota
  • Makoto Ohmoto
  • Bedrich Mosinger
  • Zheng Zhang
  • Klaus Deckmann
  • Sebastian Uhl
  • Cecil J Saunders
  • Fabián López
  • Tatsuya Yamaguchi
  • Roberto Lopez
  • Diego Restrepo
  • Sami Damak
  • Bjorn Tyrberg
  • Yuki Oka
  • Zuojun Ren
  • Arisa Oshimoto
  • Ana I Domingos
  • Thomas E Finger
  • Meghan C Eddy
  • Timothy A Gilbertson
  • Jozélia G Ferreira
  • Milena Saqui-Salces
  • Vijay Lyall
  • Yoichiro Shindo
  • Tam Hao T Phan
  • Shobha Mummalaneni
  • John A DeSimone
  • Xueying Ren
  • Yijen A Huang
  • Susanne Staaf
  • Barbara Colsoul
  • Lili R Brixel
  • Ryusuke Yoshida
  • Albino J Oliveira-Maia
  • Tadahiro Ohkuri
  • Masato S Ota
  • Vladimir Chubanov
  • Thomas Gudermann
  • Heather R Devantier
  • Gaetan Barbet
  • Thomas Voets
  • Bernd Nilius
  • Hideaki Oike
  • Nico Ruf
  • S Engemann
  • M Paulsen
  • Nina D Ullrich
  • Sara V Tran
  • David Artis
  • Ryo Kominami
  • Thomas Hofmann
  • Kevin Redding
  • Monia Michaud
  • Joel V Weinstock
  • Arthur M Blum
  • Carey Ann Gallini
  • Jun Koki
  • Lisa C Osborne

Detail Information

Publications69

  1. doi Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne, Switzerland
    J Neurosci 29:2654-62. 2009
    ..in wild-type (WT) mice and in mice lacking (1) the T1R3 receptor, (2) TRPV1, the capsaicin receptor, or (3) the TRPM5 channel, the latter being necessary for the perception of sweet, bitter, and umami tasting stimuli...
  2. ncbi TRPM5 and taste transduction
    E R Liman
    University of Southern California, 3641 Watt Way, Los Angeles, CA 90089, USA
    Handb Exp Pharmacol . 2007
    b>TRPM5 is a cation channel that it is essential for transduction of bitter, sweet and umami tastes...
  3. ncbi TRPM5-expressing solitary chemosensory cells respond to odorous irritants
    Weihong Lin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    J Neurophysiol 99:1451-60. 2008
    ..a large population of solitary chemosensory cells expressing the transient receptor potential channel M5 (TRPM5) using transgenic mice where the promoter of TRPM5 drives the expression of green fluorescent protein (GFP)...
  4. pmc Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25
    Tod R Clapp
    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    BMC Biol 4:7. 2006
    ..in subsets of Type II cells: T1R3-GFP mice were used to identify sweet- and umami-sensitive taste cells, while TRPM5-GFP mice were used to identify all cells that utilize the PLC signaling pathway for transduction...
  5. doi Food reward in the absence of taste receptor signaling
    Ivan E de Araujo
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 57:930-41. 2008
    ..Here we show that trpm5-/- mice, which lack the cellular machinery required for sweet taste transduction, can develop a robust preference ..
  6. ncbi Trpm5 null mice respond to bitter, sweet, and umami compounds
    Sami Damak
    Department of Neuroscience, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Chem Senses 31:253-64. 2006
    b>Trpm5 is a calcium-activated cation channel expressed selectively in taste receptor cells...
  7. ncbi Heat activation of TRPM5 underlies thermal sensitivity of sweet taste
    Karel Talavera
    Laboratorium voor Fysiologie, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 438:1022-5. 2005
    b>TRPM5, a cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes...
  8. pmc Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals
    Weihong Lin
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Proc Natl Acad Sci U S A 104:2471-6. 2007
    ..that a downstream signaling component of the phospholipase C pathway, the transient receptor potential channel M5 (TRPM5), is coexpressed with the cyclic nucleotide-gated channel subunit A2 in a subset of mature OSNs...
  9. pmc TRPM5-expressing microvillous cells in the main olfactory epithelium
    Weihong Lin
    Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    BMC Neurosci 9:114. 2008
    ..We previously found that in a mouse strain in which the TRPM5 promoter drives expression of the green fluorescent protein (GFP), a population of ciliated olfactory sensory ..
  10. pmc Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5
    Dan Liu
    Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 100:15160-5. 2003
    ..The ion channel, TRPM5, is an essential component of this cascade; however, the mechanism by which it is activated is not known...
  11. ncbi TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel
    Thomas Hofmann
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21215, USA
    Curr Biol 13:1153-8. 2003
    ..One member of this subfamily, TRPM5, functions in taste receptor cells and has been reported to be activated through G protein-coupled receptors ..
  12. ncbi The transduction channel TRPM5 is gated by intracellular calcium in taste cells
    Zheng Zhang
    Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 27:5777-86. 2007
    ..second-messenger cascade involving gustducin, phospholipase C beta2, and the transient receptor potential M5 (TRPM5) ion channel...
  13. ncbi A transient receptor potential channel expressed in taste receptor cells
    Cristian A Perez
    Howard Hughes Medical Institute, Mount Sinai School of Medicine, New York University, Box 1677, 1425 Madison Avenue, New York, New York 10029, USA
    Nat Neurosci 5:1169-76. 2002
    ..Among the differentially expressed clones, one encoded Trpm5, a member of the mammalian family of transient receptor potential (TRP) channels...
  14. pmc Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
    Marco Tizzano
    Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:3210-5. 2010
    ..Genetic ablation of either G alpha-gustducin or TrpM5, essential elements of the T2R transduction cascade, eliminates the trigeminal response...
  15. pmc Second-order input to the medial amygdala from olfactory sensory neurons expressing the transduction channel TRPM5
    John A Thompson
    Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, Aurora, Colorado 80045, USA
    J Comp Neurol 520:1819-30. 2012
    ..In addition, olfactory sensory neurons (OSNs) that express the transient receptor potential M5 (TRPM5) channel innervate a subset of glomeruli that respond to putative semiochemical stimuli...
  16. doi Nutrient selection in the absence of taste receptor signaling
    Xueying Ren
    The John B Pierce Laboratory, New Haven, Connecticut 06519, USA
    J Neurosci 30:8012-23. 2010
    ..Here we show that Trpm5(-/-) mice, which lack the cellular mechanisms required for sweet and several forms of l-amino acid taste ..
  17. pmc Chemoreception regulates chemical access to mouse vomeronasal organ: role of solitary chemosensory cells
    Tatsuya Ogura
    Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, Maryland, United States of America
    PLoS ONE 5:e11924. 2010
    ..These SCCs express transient receptor potential channel M5 (TRPM5) and the phospholipase C (PLC) beta2 signaling pathway...
  18. pmc TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells
    Silke Kaske
    Philipps University Marburg, Institute of Pharmacology and Toxicology, Marburg, Germany
    BMC Neurosci 8:49. 2007
    ..b>TRPM5 is known to be abundantly expressed in taste receptor cells where it participates in sweet, amino acid and bitter ..
  19. ncbi Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family
    T Enklaar
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, Mainz, D 55101, Germany
    Genomics 67:179-87. 2000
    We recently described a novel putative Ca(2+) channel gene, MTR1, which shows a high level of homology to the human TRPC7 gene and the melastatin 1 (MLSN1) gene, another Trp (transient receptor potential protein)-related gene whose ..
  20. pmc Extracellular zinc ion regulates transient receptor potential melastatin 5 (TRPM5) channel activation through its interaction with a pore loop domain
    Kunitoshi Uchida
    Division of Cell Signaling, National Institute for Physiological Sciences Okazaki Institutes for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
    J Biol Chem 288:25950-5. 2013
    The transient receptor potential melastatin 5 (TRPM5) channel is a monovalent cation channel activated by intracellular Ca(2+)...
  21. pmc Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
    Ana I Domingos
    Laboratory of Molecular Genetics, The Rockefeller University, New York, United States
    elife 2:e01462. 2013
    ..neurons project to reward areas and are required for the post-ingestive rewarding effect of sucrose in sweet-blind Trpm5(-/-) mice...
  22. pmc Transduction for pheromones in the main olfactory epithelium is mediated by the Ca2+ -activated channel TRPM5
    Fabián López
    Department of Biology, Faculty of Sciences, University of Chile, Santiago 1058, Chile, Department of Cell and Developmental Biology, Neuroscience Program, and Rocky Mountain Taste and Smell Center, Anschutz Medical Campus, University of Colorado, Aurora, Colorado 80045
    J Neurosci 34:3268-78. 2014
    ..One candidate subpopulation expresses the calcium activated cation channel TRPM5 (transient receptor potential channel M5)...
  23. pmc Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation
    Cecil J Saunders
    Rocky Mountain Taste and Smell Center, Department of Cellular and Developmental Biology and Neuroscience Program, University of Colorado School of Medicine, Anschutz Medical Center, Aurora, CO 80045
    Proc Natl Acad Sci U S A 111:6075-80. 2014
    ..Taken together, these results show that SCCs use cholinergic neurotransmission to trigger peptidergic trigeminal nociceptors, which link SCCs to the neurogenic inflammatory pathway. ..
  24. pmc Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice
    George A Kyriazis
    Diabetes and Obesity Research Center G A K, K R S, B T, T H, R E P Sanford Burnham Medical Research Institute, Orlando, Florida 32827 Translational Research Institute for Metabolism and Diabetes G A K, R E P, Florida Hospital, Orlando, Florida 32804 and Translational Science B T, Cardiovascular and Metabolic Disease, Molndal, AstraZeneca, Sweden
    Endocrinology 155:2112-21. 2014
    ..These observations further suggest that STRs might be a promising therapeutic target to prevent and treat type 2 diabetes. ..
  25. pmc Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes
    Klaus Deckmann
    Institute of Anatomy and Cell Biology, Justus Liebig University, 35385 Giessen, Germany
    Proc Natl Acad Sci U S A 111:8287-92. 2014
    ..We propose a concept of urinary bladder control involving a previously unidentified cholinergic chemosensory cell monitoring the chemical composition of the urethral luminal microenvironment for potential hazardous content. ..
  26. doi Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice
    Sebastian Uhl
    Pharmakologisches Institut, Universitat Heidelberg, Im Neuenheimer Feld 366, D 69120 Heidelberg, Germany
    J Mol Cell Cardiol 74:307-17. 2014
    TRPM4 and TRPM5 proteins belong to the Transient Receptor Potential (TRP) ion channel family and form Ca(2+)-activated nonselective cation channels...
  27. doi Bcl11b/Ctip2 is required for development of lingual papillae in mice
    Yugo Nishiguchi
    Department of Bioengineering, Graduate School of Bioscience and Bioengineering, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Dev Biol 416:98-110. 2016
    ..These results indicate that Bcl11b regulates the differentiation of keratinocytes in the tongue and identify Bcl11b as an essential factor for the lingual papilla morphogenesis. ..
  28. pmc Flavor preference conditioning by different sugars in sweet ageusic Trpm5 knockout mice
    Anthony Sclafani
    Brooklyn College and the Graduate School, City University of New York, Brooklyn, NY 11210, USA Electronic address
    Physiol Behav 140:156-63. 2015
    Knockout (KO) mice missing the taste signaling protein Trpm5 have greatly attenuated sweetener preferences but develop strong preferences for glucose in 24-h tests, which is attributed to post-oral sugar conditioning...
  29. pmc Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium
    Tatsuya Yamaguchi
    Department of Bioengineering, Graduate School of Bioscience and Bioengineering, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    BMC Neurosci 15:13. 2014
    ..Recent studies have shown that a population of microvillous cells expresses the monovalent cation channel Trpm5 (transient receptor potential channel M5)...
  30. doi Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
    Michael R Howitt
    Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, MA 02115, USA
    Science 351:1329-33. 2016
    ..Our results identify intestinal tuft cells as critical sentinels in the gut epithelium that promote type 2 immunity in response to intestinal parasites. ..
  31. pmc The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice
    John I Glendinning
    Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA
    Physiol Behav 107:50-8. 2012
    We examined the role of T1r3 and Trpm5 taste signaling proteins in carbohydrate-induced overeating and obesity...
  32. pmc Gastric tuft cells express DCLK1 and are expanded in hyperplasia
    Milena Saqui-Salces
    Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Pl BSRBI, Rm 2051, Ann Arbor, MI 48109 2200, USA
    Histochem Cell Biol 136:191-204. 2011
    ..In the adult GI tract, the tuft cell marker acTub co-expressed with DCKL1 and chemosensory markers, e.g.,TRPM5. In summary, tuft cells appear in the gastric antrum and intestine at E18...
  33. pmc A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice
    Meghan C Eddy
    Department of Biology, University of Vermont, Marsh Life Science Building, Room 113, Burlington, VT 05405, USA
    Chem Senses 37:391-401. 2012
    Previously, published studies have reported mixed results regarding the role of the TRPM5 cation channel in signaling sweet taste by taste sensory cells...
  34. pmc TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1
    Bhavik P Shah
    Department of Biology, Utah State University, Logan, Utah 84322, USA
    Am J Physiol Cell Physiol 302:C210-9. 2012
    ..LA leads to activation of monovalent cation-specific transient receptor potential channel type M5 (TRPM5) in STC-1 cells...
  35. pmc Umami taste in mice uses multiple receptors and transduction pathways
    Keiko Yasumatsu
    Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Physiol 590:1155-70. 2012
    ..from wild-type mice and mice genetically lacking T1R3 or its downstream transduction molecule, the ion channel TRPM5. Our results indicate that single umami-sensitive fibres in wild-type mice fall into two major groups: sucrose-..
  36. doi Origin of the brush cell lineage in the mouse intestinal epithelium
    Matthew Bjerknes
    Department of Medicine, Clinical Science Division, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Dev Biol 362:194-218. 2012
    ....
  37. ncbi Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain
    P Onyango
    Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genome Res 10:1697-710. 2000
    ..This study provides the first global view of the architecture of an entire imprinted domain and provides candidate sequence elements for subsequent functional analyses...
  38. pmc Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
    George A Kyriazis
    Metabolic Signaling and Disease, Diabetes and Obesity Research Center, Sanford Burnham Medical Research Institute, Orlando, FL 32827, USA
    Proc Natl Acad Sci U S A 109:E524-32. 2012
    ..on the activation of phospholipase C (PLC) and transient receptor potential cation channel, subfamily M, member 5 (TRPM5)...
  39. pmc High salt recruits aversive taste pathways
    Yuki Oka
    Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Columbia College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 494:472-5. 2013
    ..We propose that the 'co-opting' of sour and bitter neural pathways evolved as a means to ensure that high levels of salt reliably trigger robust behavioural rejection, thus preventing its potentially detrimental effects on health...
  40. pmc Potential role of transient receptor potential channel M5 in sensing putative pheromones in mouse olfactory sensory neurons
    Arisa Oshimoto
    Department of Cell and Developmental Biology, Neuroscience Program, and Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 8:e61990. 2013
    Based on pharmacological studies of chemosensory transduction in transient receptor potential channel M5 (TRPM5) knockout mice it was hypothesized that this channel is involved in transduction for a subset of putative pheromones in mouse ..
  41. pmc TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response
    Zuojun Ren
    Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA 23219, USA
    Am J Physiol Gastrointest Liver Physiol 305:G106-17. 2013
    Transient receptor potential (TRP) subfamily M member 5 (TRPM5) cation channel is involved in sensing sweet, bitter, umami, and fat taste stimuli, complex-tasting divalent salts, and temperature-induced changes in sweet taste...
  42. ncbi Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 282:37225-31. 2007
    ..We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation.
  43. pmc Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation
    Masato S Ota
    Section of Molecular Craniofacial Embryology, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Genet 5:e1000443. 2009
    ..Thus, according to our composite analyses, Hes1 is likely to play a role in orchestrating taste cell differentiation in developing taste buds...
  44. ncbi The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions
    Karel Talavera
    Laboratory of Ion Channel Research, Dept of Molecular Cell Biology, Herestraat 49, Campus Gasthuisberg, O and N1, KU Leuven, B 3000 Leuven, Belgium
    FASEB J 22:1343-55. 2008
    ..Here we report that TRPM5, a cation channel involved in sweet taste transduction, is inhibited by quinine (EC(50)=50 microM at -50 mV) owing ..
  45. ncbi Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and huma
    H Yatsuki
    Department of Biochemistry, Saga Medical School, Saga, Japan
    DNA Res 7:195-206. 2000
    ..Many expressed sequence tags (ESTs) were mapped on this locus. Three genes, Lit1 (Kvlqt1-AS), Mtr1 and Tssc4, were identified and characterized...
  46. ncbi Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse
    M Paulsen
    Max Planck Institut fur Molekulare Genetik, Ihnestrabetae 73, D 14195 Berlin, Germany
    Hum Mol Genet 9:1829-41. 2000
    ..Third, two of the orthologous gene pairs Tssc4/TSSC4 and Ltrpc5/LTRPC5 showed apparent differences in imprinting between human and mouse, whereas others like Tssc6/TSSC6 were not ..
  47. ncbi Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting
    S Engemann
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin, Germany
    Hum Mol Genet 9:2691-706. 2000
    ..One of the genes outside the cluster, Obph1, is imprinted in mouse placenta indicating that at least in extra-embryonic tissues the imprinting cluster extends into a larger domain...
  48. ncbi Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1
    Galina V Fitzpatrick
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 32:426-31. 2002
    ..These findings support the hypothesis that loss of methylation in BWS patients activates the repressive function of KvDMR1 on the maternal chromosome, resulting in abnormal silencing of CDKN1C and the development of BWS...
  49. ncbi Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice
    Nina D Ullrich
    Laboratorium voor Fysiologie, Department of Physiology, Campus Gasthuisberg, KU Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Cell Calcium 37:267-78. 2005
    ..TRPM4 and TRPM5, two Ca2+-activated cation channels of the TRP superfamily, are potential molecular correlates of NSC channels...
  50. ncbi Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains
    Dan Liu
    Division of Neurobiology, Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 280:20691-9. 2005
    b>TRPM5, a member of the superfamily of transient receptor potential ion channels, is essential for the detection of bitter, sweet, and amino acid tastes...
  51. ncbi Signal transduction of umami taste: insights from knockout mice
    Minqing Rong
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
    Chem Senses 30:i33-4. 2005
  52. ncbi Expression profiling of uniparental mouse embryos is inefficient in identifying novel imprinted genes
    Nico Ruf
    Max Delbrueck Center for Molecular Medicine, Berlin Buch, Germany
    Genomics 87:509-19. 2006
    ....
  53. ncbi Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells
    Hideaki Oike
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biochim Biophys Acta 1761:1078-84. 2006
    ..As a result of activation of G protein and phospholipase Cbeta2, the TRPM5 channel is activated...
  54. pmc Perception of sweet taste is important for voluntary alcohol consumption in mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
    Genes Brain Behav 7:1-13. 2008
    ..each lacking a gene expressed in taste buds and critical to taste transduction: alpha-gustducin (Gnat3), Tas1r3 or Trpm5. Null mutant mice lacking any of these three genes showed lower preference score for alcohol and consumed less ..
  55. pmc Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins
    Anthony Sclafani
    Dept of Psychology, Brooklyn College of the City University of New York, Brooklyn, NY 11210, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1504-13. 2007
    b>Trpm5 and alpha-gustducin are key to the transduction of tastes of sugars, amino acids, and bitter compounds...
  56. ncbi FXYD6, a Na,K-ATPase regulator, is expressed in type II taste cells
    Yoichiro Shindo
    Research Laboratories for Health and Gustatory Science, Asahi Breweries, Ltd, Midori, Moriya, Japan
    Biosci Biotechnol Biochem 75:1061-6. 2011
    ..showed that Fxyd6 was coexpressed with transient receptor potential cation channel, subfamily M, member 5 (Trpm5), a critical component of the sweet, bitter, and umami taste signal transduction pathways and that it was ..
  57. pmc The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells
    Gaetan Barbet
    Institut National de la Santé et de la Recherche Médicale U699, Paris, France
    Nat Immunol 9:1148-56. 2008
    ..Our results establish TRPM4-regulated Ca(2+) homeostasis as crucial for DC mobility but not maturation and emphasize that DC maturation and migration are independently regulated...
  58. doi Quantitative assessment of TRPM5-dependent oral aversiveness of pharmaceuticals using a mouse brief-access taste aversion assay
    Heather R Devantier
    Discovery Research, Redpoint Bio Corporation, Ewing, NJ 08628, USA
    Behav Pharmacol 19:673-82. 2008
    ..T2R G-protein coupled receptors through a peripheral signaling pathway critically dependent upon function of the TRPM5 ion channel...
  59. pmc Nicotine activates TRPM5-dependent and independent taste pathways
    Albino J Oliveira-Maia
    Instituto de Histologia e Embriologia, Faculdade de Medicina and Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200 319 Porto, Portugal
    Proc Natl Acad Sci U S A 106:1596-601. 2009
    ..Here, rats and mice were used to determine whether nicotine activates peripheral and central taste pathways via TRPM5-dependent mechanisms, which are essential for responses to other bitter tastants such as quinine, and/or via ..
  60. pmc Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity
    Tadahiro Ohkuri
    Graduate School of Dental Science, Kyushu University, Fukuoka, 812 8582, Japan
    Am J Physiol Regul Integr Comp Physiol 296:R960-71. 2009
    ..involves taste receptor type 1, member 2 (T1R2), taste receptor type 1, member 3 (T1R3), gustducin, and TRPM5. Because knockout (KO) mice lacking T1R3, gustducin's Galpha subunit (Galphagust), or TRPM5 exhibited greatly ..
  61. pmc Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5
    Zaza Kokrashvili
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 137:598-606, 606.e1-2. 2009
    ..We studied a subset of these enteroendocrine cells in duodenum that produce several peptides, including endogenous opioids, and that also express the Trpm5 cation channel.
  62. doi Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons
    Susanne Staaf
    Department of Bioscience, AstraZeneca R and D Molndal, 431 83 Mölndal, Sweden
    Gene Expr Patterns 10:65-74. 2010
    ..For most channels, the expression increased from E14 to adult with the exception of TRPM5, which displayed transient high levels during embryonic and early postnatal stages...
  63. pmc Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice
    Barbara Colsoul
    Laboratory of Ion Channel Research and Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, B 3001 Louvain, Belgium
    Proc Natl Acad Sci U S A 107:5208-13. 2010
    ..We propose that TRPM5, a Ca(2+)-activated monovalent cation channel, is a positive regulator of glucose-induced insulin release...
  64. doi TRPM5 regulates glucose-stimulated insulin secretion
    Lili R Brixel
    Centre for Paediatrics and Adolescent Medicine, University Medical Centre of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str 63, 55131 Mainz, Germany
    Pflugers Arch 460:69-76. 2010
    ..b>TRPM5 is a cation channel expressed in beta-cells and proposed to be involved in coupling intracellular Ca(2+) release ..
  65. pmc Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells
    Yijen A Huang
    Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, FL 33136, USA
    J Physiol 588:2343-50. 2010
    ..Taste-evoked ATP secretion is absent in receptor cells isolated from TRPM5 knockout mice or in taste cells from wild type mice where current through TRPM5 channels has been eliminated...
  66. ncbi Adding efficiency: the role of the CAN ion channels TRPM4 and TRPM5 in pancreatic islets
    Thorsten Enklaar
    Centre for Paediatrics and Adolescent Medicine, University Medical Centre of the Johannes Guetenberg University, Mainz, Germany
    Islets 2:337-8. 2010
    ..Recently two calcium activated nonselective (CAN) cation channels (TRPM4 and TRPM5) have been shown to influence efficient insulin response upon glucose stimulation...
  67. pmc Transient receptor potential channel type M5 is essential for fat taste
    Pin Liu
    Department of Biology, Utah State University, Logan, Utah 84322, USA
    J Neurosci 31:8634-42. 2011
    ..elicits a robust intracellular calcium rise via the activation of transient receptor potential channel type M5 (TRPM5)...

Research Grants3

  1. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  2. Putative pheromones in the main olfactory system
    Weihong Lin; Fiscal Year: 2007
    ..abstract_text> ..
  3. Sensory Transduction in the Vomeronasal System
    Emily Liman; Fiscal Year: 2005
    ....