Trib1

Summary

Gene Symbol: Trib1
Description: tribbles pseudokinase 1
Alias: A530090O15Rik, TRB-1, Trb1, tribbles homolog 1, trib1
Species: mouse

Top Publications

  1. pmc Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency
    Masahiro Yamamoto
    Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 204:2233-9. 2007
  2. ncbi Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
    Endre Kiss-Toth
    Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, United Kingdom
    J Biol Chem 279:42703-8. 2004
  3. pmc Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York, USA
    J Clin Invest 120:4410-4. 2010
  4. pmc Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells
    Emilie Dugast
    UMR1064, Institut National de la Sante et de la Recherche Medicale, Nantes 44000, France
    J Biol Chem 288:10051-60. 2013
  5. ncbi TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
    Takahiro Naiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 282:24075-82. 2007
  6. pmc Alternatively activated macrophages determine repair of the infarcted adult murine heart
    Manabu Shiraishi
    J Clin Invest 126:2151-66. 2016
  7. pmc The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis
    Di Ma
    From the Life Sciences Institute and Department of Cell and Developmental Biology and
    J Biol Chem 290:31003-12. 2015
  8. pmc Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism
    Daphné Brisard
    INRA, UMR 85 Physiologie de la Reproduction et des Comportements, Nouzilly 37380, France CNRS UMR7247, Nouzilly 37380, France Université François Rabelais de Tours, Tours 37000, France IFCE, Nouzilly 37380, France
    J Ovarian Res 7:44. 2014
  9. pmc Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet
    Tiit Ord
    Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    PLoS ONE 9:e94691. 2014
  10. doi TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions
    Yuumi Ishizuka
    Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan Department of Anatomy Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Tochigi 329 0498, Japan Health Care Food Research, Human Health Care Research, Research and Development, Kao Corporation, Sumida ku, Tokyo 131 8501, Japan Jichi Medical University Health Care Center, Shimotsuke shi, Tochigi 329 0498, Japan Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi 329 0498, Japan Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Mol Endocrinol 52:145-58. 2014

Scientific Experts

  • Endre Kiss-Toth
  • Takashi Satoh
  • Masahiro Yamamoto
  • Shizuo Akira
  • Manabu Shiraishi
  • Di Ma
  • Daphné Brisard
  • Tiit Ord
  • Yuumi Ishizuka
  • Yi Hsia Liu
  • Emilie Dugast
  • Akihiro Yoshida
  • Osamu Takeuchi
  • Anke Ostertag
  • Ralph Burkhardt
  • Priya H Dedhia
  • Minoru Takasato
  • Takahiro Naiki
  • Rie Saba
  • Hidekazu Ishida
  • Atsushi Yamaguchi
  • Kenta Yashiro
  • Yusuke Shintani
  • Hideo Adachi
  • Yasunori Shintani
  • Ken Suzuki
  • John B Hogenesch
  • Tongyu Liu
  • Crystal Rui
  • Yuanyuan Xiao
  • Siming Li
  • Jiandie D Lin
  • Y Eugene Chen
  • Lin Chang
  • Daima Ord
  • Franck Chesnel
  • Ayumi Ogawa
  • Kazuhiro Nakayama
  • Sebastien Elis
  • Supichaya Boonvisut
  • Yoshiko Yanagisawa
  • Tõnis Ord
  • Yusaku Iwasaki
  • Hiroshi Miyashita
  • Svetlana Uzbekova
  • Toshihiko Yada
  • Atsushi Hirao
  • Virginie Maillard
  • Kersti Lilleväli
  • Eero Vasar
  • Saho Makishima
  • Laura Sánchez-Lazo
  • Jürgen Innos
  • Sulev Koks
  • Silva Sütt
  • Alice Desmarchais
  • Manon Chasles
  • Sadahiko Iwamoto
  • Masafumi Takahashi
  • Triin Tekko
  • Joanna Ashton-Chess
  • Jonathan R Lamb
  • Karen A L Tan
  • Sophie Conchon
  • Mélanie Chesneau
  • Virginie Pichard
  • Ikuko Nakamae
  • Yoshichika Yoshioka
  • Katsuhiro Nakagawa
  • Hiroyasu Kidoya
  • Ségolène Pettré
  • Ivan W Morrison
  • Eiichi Morii
  • Naoki Takemura
  • Sophie Brouard
  • Hisamichi Naito
  • Noriko Yoneda-Kato
  • Nobuyuki Takakura
  • Louise Docherty
  • Jun ya Kato
  • Jean Paul Soulillou
  • Jean Paul Judor
  • Richard Danger
  • David J Argyle
  • Megan Robblee
  • Mauricio Berriel Diaz
  • William R Lagor
  • Maria E Vega
  • Sue Anne Toh
  • Daniela Strzoda

Detail Information

Publications17

  1. pmc Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency
    Masahiro Yamamoto
    Department of Host Defense and Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Exp Med 204:2233-9. 2007
    ..b>Trib1 is reportedly involved in the regulation of NF-kappaB and MAP kinases, as well as gene expression in vitro...
  2. ncbi Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
    Endre Kiss-Toth
    Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, United Kingdom
    J Biol Chem 279:42703-8. 2004
    ..These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK...
  3. pmc Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice
    Ralph Burkhardt
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York, USA
    J Clin Invest 120:4410-4. 2010
    ..This locus contains only one annotated gene, tribbles homolog 1 (TRIB1), which has not previously been implicated in lipoprotein metabolism...
  4. pmc Identification of tribbles-1 as a novel binding partner of Foxp3 in regulatory T cells
    Emilie Dugast
    UMR1064, Institut National de la Sante et de la Recherche Medicale, Nantes 44000, France
    J Biol Chem 288:10051-60. 2013
    In a previous study, we identified TRIB1, a serine-threonine kinase-like molecule, as a biomarker of chronic antibody-mediated rejection of human kidneys when measured in peripheral blood mononuclear cells...
  5. ncbi TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta
    Takahiro Naiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    J Biol Chem 282:24075-82. 2007
    ..Whereas all the three TRBs were expressed in 3T3-L1 preadipocytes, TRB2 and TRB3, but not TRB1, were immediately down-regulated by differentiation stimuli...
  6. pmc Alternatively activated macrophages determine repair of the infarcted adult murine heart
    Manabu Shiraishi
    J Clin Invest 126:2151-66. 2016
    ..We evaluated mice lacking the kinase TRIB1 (Trib1-/-), which exhibit a selective depletion of M2 macrophages after MI...
  7. pmc The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis
    Di Ma
    From the Life Sciences Institute and Department of Cell and Developmental Biology and
    J Biol Chem 290:31003-12. 2015
    ..of lipid-associated genes in the liver and markedly reduced the expression of the non-rhythmically expressed gene Trib1. Adenovirus-mediated rescue of Trib1 expression lowered plasma PCSK9 levels, increased LDL receptor protein ..
  8. pmc Tribbles expression in cumulus cells is related to oocyte maturation and fatty acid metabolism
    Daphné Brisard
    INRA, UMR 85 Physiologie de la Reproduction et des Comportements, Nouzilly 37380, France CNRS UMR7247, Nouzilly 37380, France Université François Rabelais de Tours, Tours 37000, France IFCE, Nouzilly 37380, France
    J Ovarian Res 7:44. 2014
    In mammals, the Tribbles family includes widely expressed serine-threonine kinase-like proteins (TRIB1, TRIB2 and TRIB3) that are involved in multiple biological processes including cell proliferation and fatty acid (FA) metabolism...
  9. pmc Trib3 is developmentally and nutritionally regulated in the brain but is dispensable for spatial memory, fear conditioning and sensing of amino acid-imbalanced diet
    Tiit Ord
    Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    PLoS ONE 9:e94691. 2014
    ....
  10. doi TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions
    Yuumi Ishizuka
    Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan Department of Anatomy Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Tochigi 329 0498, Japan Health Care Food Research, Human Health Care Research, Research and Development, Kao Corporation, Sumida ku, Tokyo 131 8501, Japan Jichi Medical University Health Care Center, Shimotsuke shi, Tochigi 329 0498, Japan Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi 329 0498, Japan Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    J Mol Endocrinol 52:145-58. 2014
    Mammalian tribbles homolog 1 (TRIB1) regulates hepatic lipogenesis and is genetically associated with plasma triglyceride (TG) levels and cholesterol, but the molecular mechanisms remain obscure...
  11. doi Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBPβ and TNF-α
    Yi Hsia Liu
    Royal Dick School of Veterinary Studies and Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    Vet Immunol Immunopathol 155:67-75. 2013
    In mammals, three Tribbles gene family members have been identified, Tribbles 1, 2 and 3 (Trib1, Trib2 and Trib3)...
  12. doi COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1
    Akihiro Yoshida
    Department of Tumor Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Blood 122:1750-60. 2013
    ..In this process, mammalian homolog of Tribbles, Trib1, which contains a COP1-binding motif, is essential for down-regulation of C/EBPα expression...
  13. doi Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages
    Takashi Satoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nature 495:524-8. 2013
    ..b>Trib1 is an adaptor protein involved in protein degradation by interacting with COP1 ubiquitin ligase...
  14. pmc Control of adipose tissue inflammation through TRB1
    Anke Ostertag
    1Emmy Noether and Marie Curie Research Group, Molecular Metabolic Control, DKFZ ZMBH Alliance, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Diabetes 59:1991-2000. 2010
    ..Therefore, this study aimed to test the hypothesis that the TRB gene family fulfills broader functions in the integration of metabolic and inflammatory pathways in various tissues...
  15. pmc Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia
    Priya H Dedhia
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 116:1321-8. 2010
    b>Trib1, Trib2, and Trib3 are mammalian homologs of Tribbles, an evolutionarily conserved Drosophila protein family that mediates protein degradation...
  16. doi Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development
    Minoru Takasato
    Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Biochem Biophys Res Commun 373:648-52. 2008
    ..However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development...