Genomes and Genes
Gene Symbol: Trf
Alias: AI266983, Cd176, Tfn, hpx, serotransferrin, beta-1 metal-binding globulin, hypotransferrinemia with hemochromatosis, siderophilin
Publications101 found, 100 shown here
- Transferrin and its receptor in the development of genetically determined neural tube defects in the mouse embryoC Hoyle
Neural Development Unit, University of London, United Kingdom
Dev Dyn 207:35-46. 1996..Only a proportion of embryos are able to mount this compensatory response leading to the observed partial penetrance of developmental defects in the curly tail mutant mouse...
- Transferrin overexpression alters testicular function in aged miceC Lecureuil
UMR 6175 Institut National de la Recherche Agronomique, Centre National de Recherche Scientifique, Universite de Tours, Haras Nationaux Physiologie de la Reproduction et des Comportements, Nouzilly, France
Mol Reprod Dev 74:197-206. 2007..Collectively, our data show that Tf overexpression has negative effects on testicular function and that Tf levels require strict regulation in the testis...
- Transferrin is a major determinant of hepcidin expression in hypotransferrinemic miceThomas B Bartnikas
Department of Pathology, Children s Hospital, Boston, MA, USA
Blood 117:630-7. 2011..Tf) in the regulation of hepcidin expression by these factors in vivo, we employed the hypotransferrinemic (hpx) mouse. These Tf-deficient mice have severe microcytic anemia, tissue iron overload, and hepcidin deficiency...
- Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog bindingMariana I Capurro
Division of Molecular and Cell Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N3M5, Canada
Dev Cell 14:700-11. 2008....
- The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6S P Oh
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
Genomics 14:225-31. 1992..This information should prove useful in determining the role of type XII collagen genes as candidate genes in inheritable connective tissue diseases...
- Expression from the transferrin gene promoter in transgenic miceR L Idzerda
Department of Pharmacology, School of Medicine, University of Washington, Seattle 98195
Mol Cell Biol 9:5154-62. 1989..These results demonstrate the presence of a growth hormone-responsive element between -3 and +50 kb in the 5'-flanking region of the mTf gene promoter...
- Transferrin is an early marker of hepatic differentiation, and its expression correlates with the postnatal development of oligodendrocytes in miceR Cassia
Department of Neurobiology, University of California, Los Angeles, USA
J Neurosci Res 50:421-32. 1997..The expression of the reporter gene during development was analyzed...
- The molecular defect in hypotransferrinemic miceC C Trenor
Howard Hughes Medical Institute and Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Blood 96:1113-8. 2000Hypotransferrinemic (Trf(hpx/hpx)) mice have a severe deficiency in serum transferrin (Trf) as the result of a spontaneous mutation linked to the murine Trf locus...
- Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in miceThomas B Bartnikas
Department of Pathology, Children s Hospital, Boston, MA 02115, USA
Haematologica 97:189-92. 2012..Mice deficient in transferrin (Tf(hpx/hpx)) and hemojuvelin (Hjv(-/-)), a gene mutated in juvenile hemochromatosis, a disease of hepcidin deficiency and ..
- Non-transferrin-bound iron species in the serum of hypotransferrinaemic miceR J Simpson
Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London, UK
Biochim Biophys Acta 1156:19-26. 1992..The iron may be distinguished from known extracellular iron proteins and haem-proteins by its availability to hot acid extractions...
- Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9S J Degen
Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio
Genomics 13:1368-9. 1992..for hepatocyte growth factor-like protein has been localized to mouse chromosome 9 at a locus (Hgfl) distal to the Trf locus. The likely gene order in this region is centromere-Trf-Gnai-2-Hgfl-Cck...
- Regulation of transferrin gene expressionM M Zakin
Unité d Expression des Gènes Eucaryotes, Institut Pasteur, Paris, France
FASEB J 6:3253-8. 1992..It is interesting to point out that this occurs in tissues arising from different embryological origin...
- Effect of hypoxic exposure on iron absorption in heterozygous hypotransferrinaemic miceR J Simpson
Department Clinical Biochemistry, King s College School of Medicine and Dentistry, London, United Kingdom
Ann Hematol 65:260-4. 1992....
- A proximal mouse chromosome 9 linkage map that further defines linkage groups homologous with segments of human chromosomes 11, 15, and 19M F Seldin
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
Genomics 9:678-85. 1991..3 cM-Icam-1/Ldlr-18.4 cM-Thy-1-1.8 cM-Ncam-0.9 cM-Hexa-7.9 cM-Gsta-7.9 cM-Trf. Three of these loci, Pvs, Icam-1, and Hexa, have not been mapped previously...
- A hereditary model of slowly progressive polycystic kidney disease in the mouseH Takahashi
Laboratory Animal Center, School of Medicine, Fujita Health University, Aichi, Japan
J Am Soc Nephrol 1:980-9. 1991..We conclude that the DBA/2-pcy mouse has a form of renal cystic disease that appears similar in many respects to that seen in the dominant form of human PKD...
- Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesityJ M Friedman
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
Genomics 5:463-9. 1989....
- Lactotransferrin is the major estrogen inducible protein of mouse uterine secretionsB T Pentecost
J Biol Chem 262:10134-9. 1987..In contrast, the mRNA is virtually undetectable in rat uterine tissue following estrogen administration. The estrogenic stimulation in mouse uterus contrasts with the known prolactin dependence in mammary gland...
- Cellular distribution of iron, transferrin, and ferritin in the hypotransferrinemic (Hp) mouse brainT K Dickinson
George M Leader Family Laboratory for Alzheimer s Disease Research, Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, M S Hershey Medical Center, Hershey 17033, USA
J Comp Neurol 355:67-80. 1995....
- Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1qT E Broad
Gene Mapping Unit, AgResearch Grasslands Research Centre, Palmerston North, New Zealand
Mamm Genome 6:202-5. 1995..The in situ localization of transferrin (TF) to sheep Chr 1q42-q45 confirms our previous assignment of this locus and independently anchors the eight new syntenic loci to sheep Chr 1q...
- S-laminin: mapping to mouse chromosome 9 and expression in the linked mutants tippy and duckyB E Porter
Department of Anatomy and Neurobiology, Washington University Medical Center, St Louis, Missouri 63110
Genomics 16:278-81. 1993..No abnormality of the S-laminin gene or protein was detectable in either mutant...
- Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivoK H Kaestner
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
Genes Dev 13:495-504. 1999..We also showed that HNF3alpha could bind to and transactivate the proglucagon gene promoter. These observations invoke a central role for HNF3alpha in the regulatory control of islet genes essential for glucose homeostasis in vivo...
- Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disordersF Canonne-Hergaux
Department of Biochemistry, McGill University, Montreal, Canada
Blood 97:1138-40. 2001..subcellular localization of DMT1 protein in 3 mouse models of iron overload were examined: hypotransferrinemic (Trf(hpx)) mice, Hfe knockout mice, and B2m knockout mice...
- Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic miceAtsushi Takeda
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
Biometals 15:33-6. 2002..However, the iron seems to be unavailable for the production of hemoglobin. These results suggest that transferrin-dependent iron uptake by erythroid cells in the bone marrow is essential for the development of erythrocytes...
- Hereditary differences in serum proteins of normal miceS Thompson
Proc Soc Exp Biol Med 87:315-7. 1954
- Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartmentFranck Coumailleau
Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Mol Biol Cell 15:4444-56. 2004..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane...
- Comparative studies of duodenal and macrophage ferroportin proteinsFrançois Canonne-Hergaux
Institut National de la Sante et de la Recherche Medicale, U 656, Faculte de Medecine Xavier Bichat, 16, rue Henri Huchard, 75018 Paris, France
Am J Physiol Gastrointest Liver Physiol 290:G156-63. 2006..Our data also confirm a predominant regulation of ferroportin through systemic regulator(s) likely including hepcidin...
- Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse developmentDonghoon Yoon
Hematology Section, University of Utah, Salt Lake City, Utah 84132, USA
J Biol Chem 281:25703-11. 2006..These results identify a novel role for HIF-1 in the regulation of iron homeostasis and reveal unexpected regulatory differences in Epo/EpoR signaling in yolk sac and embryonic erythropoiesis...
- Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activationKiyo aki Ishii
Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
Nat Med 15:259-66. 2009....
- Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivoM Mortensen
Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
Proc Natl Acad Sci U S A 107:832-7. 2010..In summary, we show that the selective removal of mitochondria by autophagy, but not other organelles, during erythropoeisis is essential and that this is a necessary developmental step in erythroid cells...
- The ciliary pocket: an endocytic membrane domain at the base of primary and motile ciliaAnahi Molla-Herman
Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris 75014, France
J Cell Sci 123:1785-95. 2010..Our data therefore highlight the conserved role of membrane trafficking in the vicinity of cilia...
- Apotransferrin protects cortical neurons from hemoglobin toxicityJing Chen-Roetling
Department of Emergency Medicine, Thomas Jefferson University, 1025 Walnut Street, College Building Room 813, Philadelphia, PA 19107, USA
Neuropharmacology 60:423-31. 2011..These results suggest that apotransferrin may mitigate the neurotoxicity of hemoglobin after intracerebral hemorrhage. Increasing its concentration in perihematomal tissue may be beneficial...
- BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic miceNeeta Patel
Diabetes and Nutritional Sciences Division, School of Medicine, Kings College London, London WC2R 2LS, United Kingdom
J Biol Chem 287:4099-106. 2012..was found to be overexpressed at the mRNA and protein levels in liver of genetically hypotransferrinemic mice (Trf(hpx/hpx))...
- Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansionJiayun Lu
Joint Program in Transfusion Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Exp Hematol 40:307-17.e3. 2012..However, widespread Fak inactivation in the hematopoietic system induces an increased and activated HSC pool size, potentially as a result of altered reciprocal interactions between HSCs and their microenvironment...
- Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiationEmily C Deane
Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
J Neurosci 33:595-610. 2013..These data suggest that NHE6 may play a unique, previously unrecognized, role at glutamatergic synapses that are important for learning and memory...
- Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levelsKonstantinos Gkouvatsos
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
PLoS ONE 9:e85530. 2014..These findings suggest that Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin. ..
- Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38A Rosal-Vela
Instituto de Parasitología y Biomedicina López Neyra IPBLN, CSIC, Armilla, Granada, Spain
J Proteomics 134:127-37. 2016..Among them, several citrullinated proteins and multiple serotransferrin (Tf) species were identified...
- A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptorsA Yoshimura
Cancer Research Institute, Faculty of Medicine, Kagoshima University, Japan
EMBO J 14:2816-26. 1995..Thus CIS appears to be a unique regulatory molecule for cytokine signal transduction...
- The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in miceMai Suzuki
Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women s University, Nara, Japan
PLoS ONE 7:e31854. 2012..CALM-deficient erythroid cells and embryonic fibroblasts exhibited impaired clathrin-mediated endocytosis of transferrin. These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice...
- The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresomeCarmela Fusco
Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
PLoS ONE 7:e40440. 2012..We speculate that when the proteasome activity is impaired, TRIM50 fails to drive its substrates to the proteasome-mediated degradation, and promotes their storage in the aggresome for successive clearance...
- A Sox9/Fgf feed-forward loop maintains pancreatic organ identityPhilip A Seymour
Departments of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
Development 139:3363-72. 2012..This self-promoting Sox9/Fgf10/Fgfr2b loop may regulate cell identity and organ size in a broad spectrum of developmental and regenerative contexts...
- Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptorDevin T Wiley
Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 110:8662-7. 2013..The requirement of proper avidity for nanoparticles to reach the brain parenchyma is consistent with recent behavior observed with transcytosing antibodies that bind to TfR...
- Identification and genetic monitoring of mouse inbred strains using biochemical polymorphismsA Groen
Lab Anim 11:209-14. 1977..loci coding body protein-polymorphism Es-1, Es-2, Es-3, Es-5, Gpi-1, Hbb, Id-1, Ldr-1, Mpi-1, Mup-1, Pgm-1, Trf). The allelic variation at 7 loci could be detected simultaneously...
- Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitroA J Copp
Department of Zoology, University of Oxford, United Kingdom
Dev Biol 153:312-23. 1992..5-day embryo, including the gut endoderm. These findings are consistent with a role for transferrin in development of the gut and perhaps, indirectly, in completion of neurulation during early mouse embryogenesis...
- Linkage among esterase-6 (Es-6), neural cell adhesion molecule (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8E Kobayashi
Imamichi Institute for Animal Reproduction, Ibaraki, Japan
Mamm Genome 3:656-8. 1992
- A chromosomal segment conserved since divergence of lineages leading to man and mouse: the gene order of aminoacylase-1, transferrin, and beta-galactosidase on mouse chromosome 9J H Nadeau
Genet Res 48:175-8. 1986
- Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemiaS E Bernstein
Jackson Laboratory, Bar Harbor, ME 04609
J Lab Clin Med 110:690-705. 1987..The data indicate that the gene hpx produces wholly normal strain-specific transferrin but in small amounts. The hpx gene is closely linked with the transferrin locus, Trf, on chromosome 9.
- Transferrin mRNA level in the mouse mammary gland is regulated by pregnancy and extracellular matrixL H Chen
Laboratory of Cell Biology, University of California, Berkeley 94720
J Biol Chem 262:17247-50. 1987..These findings raise the possibility that the composition of the basement membrane in the mammary gland may play a role in regulation of transferrin levels in vivo...
- Variations among sublines of inbred AKR miceR T Acton
Nat New Biol 245:8-10. 1973
- Location of the gene for Theta antigen in the mouseE P Blankenhorn
J Hered 63:259-63. 1972
- Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9J Peters
Biochem Genet 19:757-69. 1981..In addition, our results indicate that the muscle (M1) and kidney (M2) pyruvate kinase isozymes share at least one genetic determinant and may in fact be determined by the same structural gene...
- The hypotransferrinaemic mouse: ultrastructural and laser microprobe analysis observationsT C Iancu
Paediatric Research Unit, Carmel Hospital, Haifa, Israel
J Pathol 177:83-94. 1995Homozygote hypotransferrinaemic mice (hpx/hpx) have cytopathological features similar to those of human congenital atransferrinaemia, genetic haemochromatosis, and neonatal haemochromatosis...
- Developmentally regulated transcription of the four liver-specific genes for inter-alpha-inhibitor family in mouseJ P Salier
INSERM U 78, Boisguillaume, France
Biochem J 296:85-91. 1993....
- Intestinal iron absorption studies in mouse models of iron-overloadK B Raja
Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London
Br J Haematol 86:156-62. 1994..Thus, of the three models, hpx/hpx mice showed the greatest enhancement in intestinal iron absorption and net iron-loading and provides a suitable ..
- Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate concentration (Gtpc) to mouse chromosome 9J P Jenuth
Department of Paediatrics, Faculty of Medicine, University of Calgary, Canada
Genome 37:399-404. 1994..A test for linkage of Gtpc to transferrin (Trf) on chromosome 9 gave evidence of linkage with an observed recombination frequency of 14.6 +/- 5...
- Histological analysis of selected brain regions of hypotransferrinemic miceT K Dickinson
George M Leader Family Laboratory for Alzheimer s Disease Research, Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, M S Hershey Medical Center, Hershey 17033
Brain Res 635:169-78. 1994..The results of this initial study indicate the Hp animal may be an interesting model for investigating specific aspects of neural development and has considerable potential for examining the importance of iron regulation in the brain...
- Transferrin gene expression in maternal liver, fetal liver and placenta during pregnancy in the mouseJ W Kasik
MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109
Placenta 14:365-71. 1993..The data presented demonstrate an increase in mRNA transferrin in late gestation in maternal and fetal liver. Additionally, the placenta expresses a gene homologous to liver transferrin and it also is upregulated in late gestation...
- Tissue iron loading and histopathological changes in hypotransferrinaemic miceR J Simpson
Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London, U K
J Pathol 171:237-44. 1993Tissue iron loading in hypotransferrinaemic (hpx/hpx) mice was investigated as a model for genetic (primary) haemochromatosis. Iron loading of liver preceded that in the pancreas and heart...
- cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the geneK Li
Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
Genomics 16:733-9. 1993..This assignment confirms and extends the relationship between the mouse and the human chromosomes in this region of the genome...
- Unp, a mouse gene related to the tre oncogeneK Gupta
Department of Biochemistry, University of Ottawa, Canada
Oncogene 8:2307-10. 1993..We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies...
- Mouse tetranectin: cDNA sequence, tissue-specific expression, and chromosomal mappingK Ibaraki
Bone Research Branch, National Institute of Dental Research National Institutes of Health NIH, Bethesda, Maryland 20892, USA
Mamm Genome 6:693-6. 1995..Finally, the genetic map location for this gene, Tna, was determined to be on distal mouse Chromosome (Chr) 9 by analysis of two sets of multilocus crosses...
- The gene for microtubule-associated protein 4 (Mtap4) maps to the distal region of mouse chromosome 9M E Mangan
Department of Biology, University of Rochester, New York 14627, USA
Mamm Genome 7:918-9. 1996
- Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouseR L Gallo
Joint Program in Neonatology, Children s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 272:13088-93. 1997..These data suggest that inflammatory cells in the mouse can use a nonoxidative mechanism for microbial killing and permit use of the mouse to study the role such peptides play in host defense and wound repair...
- The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryoC Sirard
Amgen Institute, Toronto, Ontario M5G 2C1, Canada
Genes Dev 12:107-19. 1998..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis...
- Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissuesI Dragatsis
Department of Genetics, Columbia University, New York, NY 10032, USA
Development 125:1529-39. 1998....
- Immunohistochemical analysis of transferrin receptor: regional and cellular distribution in the hypotransferrinemic (hpx) mouse brainT K Dickinson
Division of Natural Sciences, Keuka College, Keuka Park, NY 14478, USA
Brain Res 801:171-81. 1998The hypotransferrinemic (hpx) mouse mutant produces <1% of the normal circulating level of transferrin (Tf). Heterozygote animals of this strain (hpx/+) have approximately 50% of normal plasma Tf levels...
- Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidaseB Strobl
Department of Biochemistry, Austrian Academy of Sciences, Billrothstrasse 11, Salzburg, A 5020, Austria
Genomics 53:214-9. 1998..The gene is expressed ubiquitously, the sole exception being adult brain...
- Functions of c-Jun in liver and heart developmentR Eferl
Department of Pathology, University of Graz, A 8036 Graz, Austria
J Cell Biol 145:1049-61. 1999....
- Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinitiesM L Pucci
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Am J Physiol 277:R734-41. 1999..These studies highlight the species-dependence of tissue expression and function of PGT and lay the groundwork for the use of the mouse as a model system for the study of PGT function...
- BMP type II receptor is required for gastrulation and early development of mouse embryosH Beppu
Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, 170 8455, Japan
Dev Biol 221:249-58. 2000..Our results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development...
- C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissueS S Chen
Laboratory of Molecular Pathology, Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
Mol Cell Biol 20:7292-9. 2000..Moreover, our studies with the C/ebpalpha(beta/beta) mice provide new insights into the nonredundant functions of C/EBPalpha and C/EBPbeta on gene regulation in WAT...
- Transcriptional regulation of liver developmentS A Duncan
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Dev Dyn 219:131-42. 2000..The picture that emerges is that specific transcription factors use novel mechanisms to orchestrate changes in gene expression patterns that ultimately direct cell differentiation...
- Human adolescent nephronophthisis: gene locus synteny with polycystic kidney disease in pcy miceH Omran
University Children s Hospital, Freiburg University, Freiburg, Germany
J Am Soc Nephrol 12:107-13. 2001....
- An iron-regulated ferric reductase associated with the absorption of dietary ironA T McKie
Department of Molecular Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK
Science 291:1755-9. 2001..Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway...
- Expression of stimulator of Fe transport is not enhanced in Hfe knockout miceM D Knutson
Department of Nutrition, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Nutr 131:1459-64. 2001..Important distinctions between Hfe(-/-) mice and HH patients include not only differences in the relative rate and magnitude of iron loading but also the lack of fibrosis and phlebotomy treatment in the knockout animals...
- Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk miceF Canonne-Hergaux
Department of Biochemistry, McGill University, Montreal, QC, Canada
Blood 98:3823-30. 2001..Together, these results provide further evidence that DMT1 plays a central role in iron acquisition via the transferrin cycle in erythroid cells...
- DMT1 expression is increased in the lungs of hypotransferrinemic miceAndrew J Ghio
National Health and Environmental Effects Research Laboratory, Office of Research and Development, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Am J Physiol Lung Cell Mol Physiol 284:L938-44. 2003..Increased expression of -IRE DMT1 in the lungs of the Hp mice could be responsible for elevated concentrations of the metal in these tissues...
- LINKAGE OF THE MOUSE TRANSFERRIN LOCUSD C Shreffler
J Hered 54:127-9. 1963
- Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytesAdilson Guilherme
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 279:40062-75. 2004..Taken together, these results show that EHD1 and EHBP1, but not EHD2, are required for perinuclear localization of GLUT4 and reveal that loss of EHBP1 disrupts insulin-regulated GLUT4 recycling in cultured adipocytes...
- Transferrin is required for early T-cell differentiationM Fatima Macedo
Division of Human Genetics and Genetic Disorders, Iron and the Immune System Laboratory, Institute for Molecular and Cell Biology, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
Immunology 112:543-9. 2004..In the present study we used hypotransferrinaemic (Trf(hpx/hpx)) mice to investigate the possible involvement of transferrin in T lymphocyte differentiation in vivo...
- Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranesAnne Simonsen
Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo 0310, Norway
J Cell Sci 117:4239-51. 2004..By electron microscopy, similar structures can be found within autophagosomes. We propose that Alfy might target cytosolic protein aggregates for autophagic degradation...
- Regulation of transferrin receptor 2 protein levels by transferrinAeisha Robb
Harvard School of Public Health, Department of Genetics and Complex Diseases, 665 Huntington Ave, Boston, MA 02115, USA
Blood 104:4294-9. 2004..Based on these combined results, we hypothesize that TfR2 acts as a sensor of iron status such that receptor levels reflect Tf saturation...
- Detection of activity and mass spectrometric identification of mouse liver carboxylesterase and aldehyde dehydrogenase separated by non-denaturing two-dimensional electrophoresis after extraction with detergentsYouji Shimazaki
Department of Chemistry, Faculty of Science and Venture Business Laboratory, Ehime University, Matsuyama, Japan
Biochim Biophys Acta 1749:95-101. 2005..These results indicate that the activities and identity of detergent-soluble enzymes can be examined by this non-denaturing 2-DE and mass spectrometry...
- Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in miceHiromi Gunshin
Children s Hospital, Karp Family Research Laboratories RM 8 125, Boston, MA 02115 5737, USA
Blood 106:2879-83. 2005..We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron...
- Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cellsRobert S Ohgami
Department of Pathology Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Genet 37:1264-9. 2005..Taken together, these findings indicate that Steap3 is an endosomal ferrireductase required for efficient Tf-dependent iron uptake in erythroid cells...
- Mouse polyomavirus enters early endosomes, requires their acidic pH for productive infection, and meets transferrin cargo in Rab11-positive endosomesDavid Liebl
Department of Genetics and Microbiology, Faculty of Medicine, Charles University in Prague, Vinicna 5, 128 44 Prague 2, Czech Republic
J Virol 80:4610-22. 2006..5 to 3 h), the virus meets up with transferrin in the Rab11-positive recycling endosome. These results point to a convergence of the virus and the cargo internalized by different pathways in common transitional compartments...
- Multiple polymorphic loci determine basal hepatic and splenic iron status in miceGemma R Grant
MRC Toxicology Unit, University of Leicester, Leicester, UK
Hepatology 44:174-85. 2006..In conclusion, the findings show the location of polymorphic genes that determine basal iron status in wild-type mice. Human equivalents may be pertinent in predisposition to hepatic and other disorders...
- Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imagingDerek W Bartlett
Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210 41, Pasadena, CA 91125, USA
Proc Natl Acad Sci U S A 104:15549-54. 2007..Optimization of internalization may therefore be key for the development of effective nanoparticle-based targeted therapeutics...
- The protective role of transferrin in Müller glial cells after iron-induced toxicityEmilie Picard
INSERM, U872, Paris, France
Mol Vis 14:928-41. 2008..Transferrin (Tf) expression is enhanced by aging and inflammation in humans. We investigated the role of transferrin in glial protection...
- Rap2 function requires palmitoylation and recycling endosome localizationYukiko Uechi
Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Biochem Biophys Res Commun 378:732-7. 2009..These observations implicate the involvement of palmitoylation and recycling endosome localization in cellular functions of Rap2 proteins...
- Scara5 is a ferritin receptor mediating non-transferrin iron deliveryJau Yi Li
Renal Division, College of Physicans and Surgeons, Columbia University, New York, NY 10032, USA
Dev Cell 16:35-46. 2009..These data implicate cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways...
- An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null miceRaha Mohammad-Panah
Programme in Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada
J Cell Sci 122:1229-37. 2009..In the present study, we tested for a specific role for ClC-4 in recycling endosomes by comparing transferrin (Tfn) receptor function in primary cell lines generated from ClC-4-null mice and their wild-type siblings...
- Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cellsEllen J Ezratty
Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
J Cell Biol 187:733-47. 2009....
- Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryoShigeto Miura
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Dev Dyn 240:2474-81. 2011..These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development...
- The rat gene mapC Szpirer
Curr Top Microbiol Immunol 137:33-8. 1988
- Chromosomal localization of ceruloplasmin and transferrin genes in laboratory rats, mice and in man by hybridization with specific DNA probesV S Baranov
Institute of Obstetric and Gynecology, Academy of Medical Sciences of the USSR, Leningrad
Chromosoma 96:60-6. 1987..The potential and limitations of the in situ hybridization technique with heterologous DNA probes for gene mapping in mammalian species are discussed...
- Transferrin in the central nervous system of the shiverer mouse myelin mutantJ R Connor
Department of Neuroscience and Anatomy, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
J Neurosci Res 36:501-7. 1993..These data further suggest transferrin mRNA may be constitutively expressed by oligodendrocytes and that the protein expression is regulated at the level of translation...
- The bcl-2 family member, Bcl2a1, maps to mouse chromosome 9 and human chromosome 15E Y Lin
Department of Pathology, Albert Einstein College of Medicine Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, USA
Mamm Genome 8:293-4. 1997
- Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the retinoblastoma geneC Szpirer
Departement de Biologie Moleculaire, Universite Libre de Bruxelles, Rhode St Genese, Brussels, Belgium
Oncogene 6:1319-24. 1991..The THRA1/ERBA1 and ERBB2/neu genes are thus included in a synteny group, conserved on rat chromosomes 10 and human chromosome arm 17q...
- Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21D S Threadgill
Department of Veterinary Pathology, Texas A and M University, College Station 77843
Genomics 11:1143-8. 1991..FIM3, SI, and CP mapped to bovine syntenic group U10, while RAF1 and GPX1 mapped to U12...
- Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brainE A Malecki
Department of Pediatrics, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
J Neurol Sci 170:112-8. 1999Hypotransferrinemia (hpx/hpx) is a genetic defect in mice resulting in <1% of normal plasma transferrin (Tf) concentrations; heterozygotes for this mutation (+/hpx) have low circulating Tf concentrations...
- Chromosomal mapping of the host resistance locus to rodent malaria (Plasmodium yoelii) infection in miceT Ohno
Institute for Laboratory Animal Research, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Immunogenetics 53:736-40. 2001..Elucidation of the function of this gene will provide valuable insights into the mechanism of host defense against malaria parasite infection...
- FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATIONKLAUS KAESTNER; Fiscal Year: 2003....
- Molecular Pathways of Iron Detoxification in the LungDavid Haile; Fiscal Year: 2006..This study will lead to a better understanding of iron dysfunction in diseased lungs. [unreadable] [unreadable]..
- Expression profiling of human isletsKLAUS KAESTNER; Fiscal Year: 2006....
- Development of C57BL/6 ES cell technology for high thoughput use.KLAUS KAESTNER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- FUNCTIONAL GENOMICS OF THE BETA-CELLKLAUS KAESTNER; Fiscal Year: 2007..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
- Liver Biology, Development and DiseaseKLAUS KAESTNER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..