Trf

Summary

Gene Symbol: Trf
Description: transferrin
Alias: AI266983, Cd176, Tfn, hpx, serotransferrin, beta-1 metal-binding globulin, hypotransferrinemia with hemochromatosis, siderophilin
Species: mouse

Top Publications

  1. ncbi Transferrin and its receptor in the development of genetically determined neural tube defects in the mouse embryo
    C Hoyle
    Neural Development Unit, University of London, United Kingdom
    Dev Dyn 207:35-46. 1996
  2. ncbi Transferrin overexpression alters testicular function in aged mice
    C Lecureuil
    UMR 6175 Institut National de la Recherche Agronomique, Centre National de Recherche Scientifique, Universite de Tours, Haras Nationaux Physiologie de la Reproduction et des Comportements, Nouzilly, France
    Mol Reprod Dev 74:197-206. 2007
  3. pmc Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice
    Thomas B Bartnikas
    Department of Pathology, Children s Hospital, Boston, MA, USA
    Blood 117:630-7. 2011
  4. doi Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding
    Mariana I Capurro
    Division of Molecular and Cell Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N3M5, Canada
    Dev Cell 14:700-11. 2008
  5. ncbi The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6
    S P Oh
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 14:225-31. 1992
  6. pmc Expression from the transferrin gene promoter in transgenic mice
    R L Idzerda
    Department of Pharmacology, School of Medicine, University of Washington, Seattle 98195
    Mol Cell Biol 9:5154-62. 1989
  7. ncbi Transferrin is an early marker of hepatic differentiation, and its expression correlates with the postnatal development of oligodendrocytes in mice
    R Cassia
    Department of Neurobiology, University of California, Los Angeles, USA
    J Neurosci Res 50:421-32. 1997
  8. ncbi The molecular defect in hypotransferrinemic mice
    C C Trenor
    Howard Hughes Medical Institute and Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 96:1113-8. 2000
  9. pmc Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice
    Thomas B Bartnikas
    Department of Pathology, Children s Hospital, Boston, MA 02115, USA
    Haematologica 97:189-92. 2012
  10. ncbi Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice
    R J Simpson
    Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London, UK
    Biochim Biophys Acta 1156:19-26. 1992

Research Grants

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  2. Molecular Pathways of Iron Detoxification in the Lung
    David Haile; Fiscal Year: 2006
  3. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  4. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  5. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  6. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008

Scientific Experts

  • G M Bishop
  • Thomas B Bartnikas
  • A Takeda
  • Melina Schuh
  • H Omran
  • Kishor B Raja
  • S A Duncan
  • Andrew Ghio
  • A T McKie
  • Maria de Sousa
  • Hong Fu
  • Tamio Ohno
  • Emilie Picard
  • François Canonne-Hergaux
  • Funmei Yang
  • Youji Shimazaki
  • KLAUS KAESTNER
  • David Haile
  • A Rosal-Vela
  • Konstantinos Gkouvatsos
  • Nancy C Andrews
  • Devin T Wiley
  • Emily C Deane
  • Philip A Seymour
  • Carmela Fusco
  • Mai Suzuki
  • Jiayun Lu
  • Neeta Patel
  • Shigeto Miura
  • Jing Chen-Roetling
  • M Mortensen
  • Mark E Davis
  • Anahi Molla-Herman
  • Ellen J Ezratty
  • Jau Yi Li
  • Kiyo aki Ishii
  • Raha Mohammad-Panah
  • Yukiko Uechi
  • Mariana I Capurro
  • Derek W Bartlett
  • C Lecureuil
  • T K Dickinson
  • Renee M Ned
  • David Liebl
  • Gemma R Grant
  • Donghoon Yoon
  • J R Connor
  • Hiromi Gunshin
  • Eric L Greer
  • Robert S Ohgami
  • Mark D Fleming
  • Anne Simonsen
  • Franck Coumailleau
  • Aeisha Robb
  • M Fatima Macedo
  • Adilson Guilherme
  • V Sanz-Nebot
  • S Garcia-Rodriguez
  • M Zubiaur
  • A Barroso
  • J Postigo
  • M Iglesias
  • J Sancho
  • E Gimenez
  • V Longobardo
  • A Lario
  • R Merino
  • J Merino
  • N G Copeland
  • N A Jenkins
  • Alina Daba
  • Kostas Pantopoulos
  • John Wagner
  • F Guillou
  • Carine Fillebeen
  • Giada Sebastiani
  • Alina E Ilie
  • Micaela Das Gupta
  • Saman Sizdahkhani
  • Aaron Gale
  • Paul Webster
  • John Orlowski
  • R Anne McKinney
  • M D Knutson
  • Ragai R Mitry
  • Yan Sun
  • Giuseppe Merla
  • Christopher J Lim
  • Ruiyu Xie
  • Kenji Tanabe

Detail Information

Publications101 found, 100 shown here

  1. ncbi Transferrin and its receptor in the development of genetically determined neural tube defects in the mouse embryo
    C Hoyle
    Neural Development Unit, University of London, United Kingdom
    Dev Dyn 207:35-46. 1996
    ..Only a proportion of embryos are able to mount this compensatory response leading to the observed partial penetrance of developmental defects in the curly tail mutant mouse...
  2. ncbi Transferrin overexpression alters testicular function in aged mice
    C Lecureuil
    UMR 6175 Institut National de la Recherche Agronomique, Centre National de Recherche Scientifique, Universite de Tours, Haras Nationaux Physiologie de la Reproduction et des Comportements, Nouzilly, France
    Mol Reprod Dev 74:197-206. 2007
    ..Collectively, our data show that Tf overexpression has negative effects on testicular function and that Tf levels require strict regulation in the testis...
  3. pmc Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice
    Thomas B Bartnikas
    Department of Pathology, Children s Hospital, Boston, MA, USA
    Blood 117:630-7. 2011
    ..Tf) in the regulation of hepcidin expression by these factors in vivo, we employed the hypotransferrinemic (hpx) mouse. These Tf-deficient mice have severe microcytic anemia, tissue iron overload, and hepcidin deficiency...
  4. doi Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding
    Mariana I Capurro
    Division of Molecular and Cell Biology, Sunnybrook Research Institute and Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N3M5, Canada
    Dev Cell 14:700-11. 2008
    ....
  5. ncbi The mouse alpha 1(XII) and human alpha 1(XII)-like collagen genes are localized on mouse chromosome 9 and human chromosome 6
    S P Oh
    Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
    Genomics 14:225-31. 1992
    ..This information should prove useful in determining the role of type XII collagen genes as candidate genes in inheritable connective tissue diseases...
  6. pmc Expression from the transferrin gene promoter in transgenic mice
    R L Idzerda
    Department of Pharmacology, School of Medicine, University of Washington, Seattle 98195
    Mol Cell Biol 9:5154-62. 1989
    ..These results demonstrate the presence of a growth hormone-responsive element between -3 and +50 kb in the 5'-flanking region of the mTf gene promoter...
  7. ncbi Transferrin is an early marker of hepatic differentiation, and its expression correlates with the postnatal development of oligodendrocytes in mice
    R Cassia
    Department of Neurobiology, University of California, Los Angeles, USA
    J Neurosci Res 50:421-32. 1997
    ..The expression of the reporter gene during development was analyzed...
  8. ncbi The molecular defect in hypotransferrinemic mice
    C C Trenor
    Howard Hughes Medical Institute and Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 96:1113-8. 2000
    Hypotransferrinemic (Trf(hpx/hpx)) mice have a severe deficiency in serum transferrin (Trf) as the result of a spontaneous mutation linked to the murine Trf locus...
  9. pmc Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice
    Thomas B Bartnikas
    Department of Pathology, Children s Hospital, Boston, MA 02115, USA
    Haematologica 97:189-92. 2012
    ..Mice deficient in transferrin (Tf(hpx/hpx)) and hemojuvelin (Hjv(-/-)), a gene mutated in juvenile hemochromatosis, a disease of hepcidin deficiency and ..
  10. ncbi Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice
    R J Simpson
    Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London, UK
    Biochim Biophys Acta 1156:19-26. 1992
    ..The iron may be distinguished from known extracellular iron proteins and haem-proteins by its availability to hot acid extractions...
  11. ncbi Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9
    S J Degen
    Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio
    Genomics 13:1368-9. 1992
    ..for hepatocyte growth factor-like protein has been localized to mouse chromosome 9 at a locus (Hgfl) distal to the Trf locus. The likely gene order in this region is centromere-Trf-Gnai-2-Hgfl-Cck...
  12. ncbi Regulation of transferrin gene expression
    M M Zakin
    Unité d Expression des Gènes Eucaryotes, Institut Pasteur, Paris, France
    FASEB J 6:3253-8. 1992
    ..It is interesting to point out that this occurs in tissues arising from different embryological origin...
  13. ncbi Effect of hypoxic exposure on iron absorption in heterozygous hypotransferrinaemic mice
    R J Simpson
    Department Clinical Biochemistry, King s College School of Medicine and Dentistry, London, United Kingdom
    Ann Hematol 65:260-4. 1992
    ....
  14. ncbi A proximal mouse chromosome 9 linkage map that further defines linkage groups homologous with segments of human chromosomes 11, 15, and 19
    M F Seldin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 9:678-85. 1991
    ..3 cM-Icam-1/Ldlr-18.4 cM-Thy-1-1.8 cM-Ncam-0.9 cM-Hexa-7.9 cM-Gsta-7.9 cM-Trf. Three of these loci, Pvs, Icam-1, and Hexa, have not been mapped previously...
  15. ncbi A hereditary model of slowly progressive polycystic kidney disease in the mouse
    H Takahashi
    Laboratory Animal Center, School of Medicine, Fujita Health University, Aichi, Japan
    J Am Soc Nephrol 1:980-9. 1991
    ..We conclude that the DBA/2-pcy mouse has a form of renal cystic disease that appears similar in many respects to that seen in the dominant form of human PKD...
  16. ncbi Level of expression and chromosome mapping of the mouse cholecystokinin gene: implications for murine models of genetic obesity
    J M Friedman
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Genomics 5:463-9. 1989
    ....
  17. ncbi Lactotransferrin is the major estrogen inducible protein of mouse uterine secretions
    B T Pentecost
    J Biol Chem 262:10134-9. 1987
    ..In contrast, the mRNA is virtually undetectable in rat uterine tissue following estrogen administration. The estrogenic stimulation in mouse uterus contrasts with the known prolactin dependence in mammary gland...
  18. ncbi Cellular distribution of iron, transferrin, and ferritin in the hypotransferrinemic (Hp) mouse brain
    T K Dickinson
    George M Leader Family Laboratory for Alzheimer s Disease Research, Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, M S Hershey Medical Center, Hershey 17033, USA
    J Comp Neurol 355:67-80. 1995
    ....
  19. ncbi Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q
    T E Broad
    Gene Mapping Unit, AgResearch Grasslands Research Centre, Palmerston North, New Zealand
    Mamm Genome 6:202-5. 1995
    ..The in situ localization of transferrin (TF) to sheep Chr 1q42-q45 confirms our previous assignment of this locus and independently anchors the eight new syntenic loci to sheep Chr 1q...
  20. ncbi S-laminin: mapping to mouse chromosome 9 and expression in the linked mutants tippy and ducky
    B E Porter
    Department of Anatomy and Neurobiology, Washington University Medical Center, St Louis, Missouri 63110
    Genomics 16:278-81. 1993
    ..No abnormality of the S-laminin gene or protein was detectable in either mutant...
  21. pmc Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Genes Dev 13:495-504. 1999
    ..We also showed that HNF3alpha could bind to and transactivate the proglucagon gene promoter. These observations invoke a central role for HNF3alpha in the regulatory control of islet genes essential for glucose homeostasis in vivo...
  22. ncbi Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders
    F Canonne-Hergaux
    Department of Biochemistry, McGill University, Montreal, Canada
    Blood 97:1138-40. 2001
    ..subcellular localization of DMT1 protein in 3 mouse models of iron overload were examined: hypotransferrinemic (Trf(hpx)) mice, Hfe knockout mice, and B2m knockout mice...
  23. ncbi Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic mice
    Atsushi Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
    Biometals 15:33-6. 2002
    ..However, the iron seems to be unavailable for the production of hemoglobin. These results suggest that transferrin-dependent iron uptake by erythroid cells in the bone marrow is essential for the development of erythrocytes...
  24. ncbi Hereditary differences in serum proteins of normal mice
    S Thompson
    Proc Soc Exp Biol Med 87:315-7. 1954
  25. pmc Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment
    Franck Coumailleau
    Unité Biologie du Développement, CNRS URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Biol Cell 15:4444-56. 2004
    ..Rffl overexpression represents a novel means to inhibit recycling that will help to understand the mechanisms involved in recycling from the ERC to the plasma membrane...
  26. ncbi Comparative studies of duodenal and macrophage ferroportin proteins
    François Canonne-Hergaux
    Institut National de la Sante et de la Recherche Medicale, U 656, Faculte de Medecine Xavier Bichat, 16, rue Henri Huchard, 75018 Paris, France
    Am J Physiol Gastrointest Liver Physiol 290:G156-63. 2006
    ..Our data also confirm a predominant regulation of ferroportin through systemic regulator(s) likely including hepcidin...
  27. ncbi Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development
    Donghoon Yoon
    Hematology Section, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 281:25703-11. 2006
    ..These results identify a novel role for HIF-1 in the regulation of iron homeostasis and reveal unexpected regulatory differences in Epo/EpoR signaling in yolk sac and embryonic erythropoiesis...
  28. doi Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation
    Kiyo aki Ishii
    Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology NCGG, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Nat Med 15:259-66. 2009
    ....
  29. pmc Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
    M Mortensen
    Nuffield Department of Medicine, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 107:832-7. 2010
    ..In summary, we show that the selective removal of mitochondria by autophagy, but not other organelles, during erythropoeisis is essential and that this is a necessary developmental step in erythroid cells...
  30. doi The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia
    Anahi Molla-Herman
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris 75014, France
    J Cell Sci 123:1785-95. 2010
    ..Our data therefore highlight the conserved role of membrane trafficking in the vicinity of cilia...
  31. pmc Apotransferrin protects cortical neurons from hemoglobin toxicity
    Jing Chen-Roetling
    Department of Emergency Medicine, Thomas Jefferson University, 1025 Walnut Street, College Building Room 813, Philadelphia, PA 19107, USA
    Neuropharmacology 60:423-31. 2011
    ..These results suggest that apotransferrin may mitigate the neurotoxicity of hemoglobin after intracerebral hemorrhage. Increasing its concentration in perihematomal tissue may be beneficial...
  32. pmc BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice
    Neeta Patel
    Diabetes and Nutritional Sciences Division, School of Medicine, Kings College London, London WC2R 2LS, United Kingdom
    J Biol Chem 287:4099-106. 2012
    ..was found to be overexpressed at the mRNA and protein levels in liver of genetically hypotransferrinemic mice (Trf(hpx/hpx))...
  33. pmc Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion
    Jiayun Lu
    Joint Program in Transfusion Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Exp Hematol 40:307-17.e3. 2012
    ..However, widespread Fak inactivation in the hematopoietic system induces an increased and activated HSC pool size, potentially as a result of altered reciprocal interactions between HSCs and their microenvironment...
  34. doi Enhanced recruitment of endosomal Na+/H+ exchanger NHE6 into Dendritic spines of hippocampal pyramidal neurons during NMDA receptor-dependent long-term potentiation
    Emily C Deane
    Department of Neurology and Neurosurgery, McGill University, Montreal, Canada
    J Neurosci 33:595-610. 2013
    ..These data suggest that NHE6 may play a unique, previously unrecognized, role at glutamatergic synapses that are important for learning and memory...
  35. pmc Iron-dependent regulation of hepcidin in Hjv-/- mice: evidence that hemojuvelin is dispensable for sensing body iron levels
    Konstantinos Gkouvatsos
    Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada
    PLoS ONE 9:e85530. 2014
    ..These findings suggest that Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin. ..
  36. doi Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38
    A Rosal-Vela
    Instituto de Parasitología y Biomedicina López Neyra IPBLN, CSIC, Armilla, Granada, Spain
    J Proteomics 134:127-37. 2016
    ..Among them, several citrullinated proteins and multiple serotransferrin (Tf) species were identified...
  37. pmc A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
    A Yoshimura
    Cancer Research Institute, Faculty of Medicine, Kagoshima University, Japan
    EMBO J 14:2816-26. 1995
    ..Thus CIS appears to be a unique regulatory molecule for cytokine signal transduction...
  38. pmc The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice
    Mai Suzuki
    Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women s University, Nara, Japan
    PLoS ONE 7:e31854. 2012
    ..CALM-deficient erythroid cells and embryonic fibroblasts exhibited impaired clathrin-mediated endocytosis of transferrin. These results indicate that CALM is required for erythroid maturation and transferrin internalization in mice...
  39. pmc The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome
    Carmela Fusco
    Medical Genetics Unit, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy
    PLoS ONE 7:e40440. 2012
    ..We speculate that when the proteasome activity is impaired, TRIM50 fails to drive its substrates to the proteasome-mediated degradation, and promotes their storage in the aggresome for successive clearance...
  40. pmc A Sox9/Fgf feed-forward loop maintains pancreatic organ identity
    Philip A Seymour
    Departments of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093 0695, USA
    Development 139:3363-72. 2012
    ..This self-promoting Sox9/Fgf10/Fgfr2b loop may regulate cell identity and organ size in a broad spectrum of developmental and regenerative contexts...
  41. pmc Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor
    Devin T Wiley
    Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 110:8662-7. 2013
    ..The requirement of proper avidity for nanoparticles to reach the brain parenchyma is consistent with recent behavior observed with transcytosing antibodies that bind to TfR...
  42. ncbi Identification and genetic monitoring of mouse inbred strains using biochemical polymorphisms
    A Groen
    Lab Anim 11:209-14. 1977
    ..loci coding body protein-polymorphism Es-1, Es-2, Es-3, Es-5, Gpi-1, Hbb, Id-1, Ldr-1, Mpi-1, Mup-1, Pgm-1, Trf). The allelic variation at 7 loci could be detected simultaneously...
  43. ncbi Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro
    A J Copp
    Department of Zoology, University of Oxford, United Kingdom
    Dev Biol 153:312-23. 1992
    ..5-day embryo, including the gut endoderm. These findings are consistent with a role for transferrin in development of the gut and perhaps, indirectly, in completion of neurulation during early mouse embryogenesis...
  44. ncbi Linkage among esterase-6 (Es-6), neural cell adhesion molecule (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8
    E Kobayashi
    Imamichi Institute for Animal Reproduction, Ibaraki, Japan
    Mamm Genome 3:656-8. 1992
  45. ncbi A chromosomal segment conserved since divergence of lineages leading to man and mouse: the gene order of aminoacylase-1, transferrin, and beta-galactosidase on mouse chromosome 9
    J H Nadeau
    Genet Res 48:175-8. 1986
  46. ncbi Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia
    S E Bernstein
    Jackson Laboratory, Bar Harbor, ME 04609
    J Lab Clin Med 110:690-705. 1987
    ..The data indicate that the gene hpx produces wholly normal strain-specific transferrin but in small amounts. The hpx gene is closely linked with the transferrin locus, Trf, on chromosome 9.
  47. ncbi Transferrin mRNA level in the mouse mammary gland is regulated by pregnancy and extracellular matrix
    L H Chen
    Laboratory of Cell Biology, University of California, Berkeley 94720
    J Biol Chem 262:17247-50. 1987
    ..These findings raise the possibility that the composition of the basement membrane in the mammary gland may play a role in regulation of transferrin levels in vivo...
  48. ncbi Variations among sublines of inbred AKR mice
    R T Acton
    Nat New Biol 245:8-10. 1973
  49. ncbi Location of the gene for Theta antigen in the mouse
    E P Blankenhorn
    J Hered 63:259-63. 1972
  50. ncbi Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9
    J Peters
    Biochem Genet 19:757-69. 1981
    ..In addition, our results indicate that the muscle (M1) and kidney (M2) pyruvate kinase isozymes share at least one genetic determinant and may in fact be determined by the same structural gene...
  51. ncbi The hypotransferrinaemic mouse: ultrastructural and laser microprobe analysis observations
    T C Iancu
    Paediatric Research Unit, Carmel Hospital, Haifa, Israel
    J Pathol 177:83-94. 1995
    Homozygote hypotransferrinaemic mice (hpx/hpx) have cytopathological features similar to those of human congenital atransferrinaemia, genetic haemochromatosis, and neonatal haemochromatosis...
  52. pmc Developmentally regulated transcription of the four liver-specific genes for inter-alpha-inhibitor family in mouse
    J P Salier
    INSERM U 78, Boisguillaume, France
    Biochem J 296:85-91. 1993
    ....
  53. ncbi Intestinal iron absorption studies in mouse models of iron-overload
    K B Raja
    Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London
    Br J Haematol 86:156-62. 1994
    ..Thus, of the three models, hpx/hpx mice showed the greatest enhancement in intestinal iron absorption and net iron-loading and provides a suitable ..
  54. ncbi Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate concentration (Gtpc) to mouse chromosome 9
    J P Jenuth
    Department of Paediatrics, Faculty of Medicine, University of Calgary, Canada
    Genome 37:399-404. 1994
    ..A test for linkage of Gtpc to transferrin (Trf) on chromosome 9 gave evidence of linkage with an observed recombination frequency of 14.6 +/- 5...
  55. ncbi Histological analysis of selected brain regions of hypotransferrinemic mice
    T K Dickinson
    George M Leader Family Laboratory for Alzheimer s Disease Research, Department of Neuroscience and Anatomy, Pennsylvania State University, College of Medicine, M S Hershey Medical Center, Hershey 17033
    Brain Res 635:169-78. 1994
    ..The results of this initial study indicate the Hp animal may be an interesting model for investigating specific aspects of neural development and has considerable potential for examining the importance of iron regulation in the brain...
  56. ncbi Transferrin gene expression in maternal liver, fetal liver and placenta during pregnancy in the mouse
    J W Kasik
    MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109
    Placenta 14:365-71. 1993
    ..The data presented demonstrate an increase in mRNA transferrin in late gestation in maternal and fetal liver. Additionally, the placenta expresses a gene homologous to liver transferrin and it also is upregulated in late gestation...
  57. ncbi Tissue iron loading and histopathological changes in hypotransferrinaemic mice
    R J Simpson
    Department of Clinical Biochemistry, King s College School of Medicine and Dentistry, London, U K
    J Pathol 171:237-44. 1993
    Tissue iron loading in hypotransferrinaemic (hpx/hpx) mice was investigated as a model for genetic (primary) haemochromatosis. Iron loading of liver preceded that in the pancreas and heart...
  58. ncbi cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene
    K Li
    Department of Dermatology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Genomics 16:733-9. 1993
    ..This assignment confirms and extends the relationship between the mouse and the human chromosomes in this region of the genome...
  59. ncbi Unp, a mouse gene related to the tre oncogene
    K Gupta
    Department of Biochemistry, University of Ottawa, Canada
    Oncogene 8:2307-10. 1993
    ..We have localized the Unp gene to mouse chromosome 9 in a region of homology with human chromosome 3p. This region has been implicated in a number of human malignancies...
  60. ncbi Mouse tetranectin: cDNA sequence, tissue-specific expression, and chromosomal mapping
    K Ibaraki
    Bone Research Branch, National Institute of Dental Research National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Mamm Genome 6:693-6. 1995
    ..Finally, the genetic map location for this gene, Tna, was determined to be on distal mouse Chromosome (Chr) 9 by analysis of two sets of multilocus crosses...
  61. ncbi The gene for microtubule-associated protein 4 (Mtap4) maps to the distal region of mouse chromosome 9
    M E Mangan
    Department of Biology, University of Rochester, New York 14627, USA
    Mamm Genome 7:918-9. 1996
  62. ncbi Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouse
    R L Gallo
    Joint Program in Neonatology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:13088-93. 1997
    ..These data suggest that inflammatory cells in the mouse can use a nonoxidative mechanism for microbial killing and permit use of the mouse to study the role such peptides play in host defense and wound repair...
  63. pmc The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
    C Sirard
    Amgen Institute, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 12:107-19. 1998
    ..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis...
  64. ncbi Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues
    I Dragatsis
    Department of Genetics, Columbia University, New York, NY 10032, USA
    Development 125:1529-39. 1998
    ....
  65. ncbi Immunohistochemical analysis of transferrin receptor: regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain
    T K Dickinson
    Division of Natural Sciences, Keuka College, Keuka Park, NY 14478, USA
    Brain Res 801:171-81. 1998
    The hypotransferrinemic (hpx) mouse mutant produces <1% of the normal circulating level of transferrin (Tf). Heterozygote animals of this strain (hpx/+) have approximately 50% of normal plasma Tf levels...
  66. ncbi Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase
    B Strobl
    Department of Biochemistry, Austrian Academy of Sciences, Billrothstrasse 11, Salzburg, A 5020, Austria
    Genomics 53:214-9. 1998
    ..The gene is expressed ubiquitously, the sole exception being adult brain...
  67. pmc Functions of c-Jun in liver and heart development
    R Eferl
    Department of Pathology, University of Graz, A 8036 Graz, Austria
    J Cell Biol 145:1049-61. 1999
    ....
  68. ncbi Cloning of mouse prostaglandin transporter PGT cDNA: species-specific substrate affinities
    M L Pucci
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 277:R734-41. 1999
    ..These studies highlight the species-dependence of tissue expression and function of PGT and lay the groundwork for the use of the mouse as a model system for the study of PGT function...
  69. ncbi BMP type II receptor is required for gastrulation and early development of mouse embryos
    H Beppu
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, 170 8455, Japan
    Dev Biol 221:249-58. 2000
    ..Our results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development...
  70. pmc C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue
    S S Chen
    Laboratory of Molecular Pathology, Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
    Mol Cell Biol 20:7292-9. 2000
    ..Moreover, our studies with the C/ebpalpha(beta/beta) mice provide new insights into the nonredundant functions of C/EBPalpha and C/EBPbeta on gene regulation in WAT...
  71. ncbi Transcriptional regulation of liver development
    S A Duncan
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 219:131-42. 2000
    ..The picture that emerges is that specific transcription factors use novel mechanisms to orchestrate changes in gene expression patterns that ultimately direct cell differentiation...
  72. ncbi Human adolescent nephronophthisis: gene locus synteny with polycystic kidney disease in pcy mice
    H Omran
    University Children s Hospital, Freiburg University, Freiburg, Germany
    J Am Soc Nephrol 12:107-13. 2001
    ....
  73. ncbi An iron-regulated ferric reductase associated with the absorption of dietary iron
    A T McKie
    Department of Molecular Medicine, Guy s, King s and St Thomas School of Medicine, King s College London, Rayne Institute, Denmark Hill Campus, 123 Coldharbour Lane, London SE5 9NU, UK
    Science 291:1755-9. 2001
    ..Duodenal expression levels of Dcytb messenger RNA and protein were regulated by changes in physiological modulators of iron absorption. Thus, Dcytb provides an important element in the iron absorption pathway...
  74. ncbi Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice
    M D Knutson
    Department of Nutrition, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Nutr 131:1459-64. 2001
    ..Important distinctions between Hfe(-/-) mice and HH patients include not only differences in the relative rate and magnitude of iron loading but also the lack of fibrosis and phlebotomy treatment in the knockout animals...
  75. ncbi Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice
    F Canonne-Hergaux
    Department of Biochemistry, McGill University, Montreal, QC, Canada
    Blood 98:3823-30. 2001
    ..Together, these results provide further evidence that DMT1 plays a central role in iron acquisition via the transferrin cycle in erythroid cells...
  76. ncbi DMT1 expression is increased in the lungs of hypotransferrinemic mice
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Am J Physiol Lung Cell Mol Physiol 284:L938-44. 2003
    ..Increased expression of -IRE DMT1 in the lungs of the Hp mice could be responsible for elevated concentrations of the metal in these tissues...
  77. ncbi LINKAGE OF THE MOUSE TRANSFERRIN LOCUS
    D C Shreffler
    J Hered 54:127-9. 1963
  78. ncbi Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes
    Adilson Guilherme
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 279:40062-75. 2004
    ..Taken together, these results show that EHD1 and EHBP1, but not EHD2, are required for perinuclear localization of GLUT4 and reveal that loss of EHBP1 disrupts insulin-regulated GLUT4 recycling in cultured adipocytes...
  79. pmc Transferrin is required for early T-cell differentiation
    M Fatima Macedo
    Division of Human Genetics and Genetic Disorders, Iron and the Immune System Laboratory, Institute for Molecular and Cell Biology, Rua do Campo Alegre 823, 4150 180 Porto, Portugal
    Immunology 112:543-9. 2004
    ..In the present study we used hypotransferrinaemic (Trf(hpx/hpx)) mice to investigate the possible involvement of transferrin in T lymphocyte differentiation in vivo...
  80. ncbi Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
    Anne Simonsen
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo 0310, Norway
    J Cell Sci 117:4239-51. 2004
    ..By electron microscopy, similar structures can be found within autophagosomes. We propose that Alfy might target cytosolic protein aggregates for autophagic degradation...
  81. ncbi Regulation of transferrin receptor 2 protein levels by transferrin
    Aeisha Robb
    Harvard School of Public Health, Department of Genetics and Complex Diseases, 665 Huntington Ave, Boston, MA 02115, USA
    Blood 104:4294-9. 2004
    ..Based on these combined results, we hypothesize that TfR2 acts as a sensor of iron status such that receptor levels reflect Tf saturation...
  82. ncbi Detection of activity and mass spectrometric identification of mouse liver carboxylesterase and aldehyde dehydrogenase separated by non-denaturing two-dimensional electrophoresis after extraction with detergents
    Youji Shimazaki
    Department of Chemistry, Faculty of Science and Venture Business Laboratory, Ehime University, Matsuyama, Japan
    Biochim Biophys Acta 1749:95-101. 2005
    ..These results indicate that the activities and identity of detergent-soluble enzymes can be examined by this non-denaturing 2-DE and mass spectrometry...
  83. pmc Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
    Hiromi Gunshin
    Children s Hospital, Karp Family Research Laboratories RM 8 125, Boston, MA 02115 5737, USA
    Blood 106:2879-83. 2005
    ..We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron...
  84. pmc Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
    Robert S Ohgami
    Department of Pathology Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 37:1264-9. 2005
    ..Taken together, these findings indicate that Steap3 is an endosomal ferrireductase required for efficient Tf-dependent iron uptake in erythroid cells...
  85. pmc Mouse polyomavirus enters early endosomes, requires their acidic pH for productive infection, and meets transferrin cargo in Rab11-positive endosomes
    David Liebl
    Department of Genetics and Microbiology, Faculty of Medicine, Charles University in Prague, Vinicna 5, 128 44 Prague 2, Czech Republic
    J Virol 80:4610-22. 2006
    ..5 to 3 h), the virus meets up with transferrin in the Rab11-positive recycling endosome. These results point to a convergence of the virus and the cargo internalized by different pathways in common transitional compartments...
  86. ncbi Multiple polymorphic loci determine basal hepatic and splenic iron status in mice
    Gemma R Grant
    MRC Toxicology Unit, University of Leicester, Leicester, UK
    Hepatology 44:174-85. 2006
    ..In conclusion, the findings show the location of polymorphic genes that determine basal iron status in wild-type mice. Human equivalents may be pertinent in predisposition to hepatic and other disorders...
  87. pmc Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
    Derek W Bartlett
    Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 210 41, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 104:15549-54. 2007
    ..Optimization of internalization may therefore be key for the development of effective nanoparticle-based targeted therapeutics...
  88. pmc The protective role of transferrin in Müller glial cells after iron-induced toxicity
    Emilie Picard
    INSERM, U872, Paris, France
    Mol Vis 14:928-41. 2008
    ..Transferrin (Tf) expression is enhanced by aging and inflammation in humans. We investigated the role of transferrin in glial protection...
  89. doi Rap2 function requires palmitoylation and recycling endosome localization
    Yukiko Uechi
    Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Biochem Biophys Res Commun 378:732-7. 2009
    ..These observations implicate the involvement of palmitoylation and recycling endosome localization in cellular functions of Rap2 proteins...
  90. pmc Scara5 is a ferritin receptor mediating non-transferrin iron delivery
    Jau Yi Li
    Renal Division, College of Physicans and Surgeons, Columbia University, New York, NY 10032, USA
    Dev Cell 16:35-46. 2009
    ..These data implicate cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways...
  91. doi An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice
    Raha Mohammad-Panah
    Programme in Molecular Structure and Function, Hospital for Sick Children, Toronto, Canada
    J Cell Sci 122:1229-37. 2009
    ..In the present study, we tested for a specific role for ClC-4 in recycling endosomes by comparing transferrin (Tfn) receptor function in primary cell lines generated from ClC-4-null mice and their wild-type siblings...
  92. pmc Clathrin mediates integrin endocytosis for focal adhesion disassembly in migrating cells
    Ellen J Ezratty
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    J Cell Biol 187:733-47. 2009
    ....
  93. pmc Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo
    Shigeto Miura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Dev Dyn 240:2474-81. 2011
    ..These results suggest that HGS is critical to localize TAK1 to early endosome for transducing BMP signaling for proper development. Our data revealed a new mechanism to modify BMP signaling by Hgs during early mouse development...
  94. ncbi The rat gene map
    C Szpirer
    Curr Top Microbiol Immunol 137:33-8. 1988
  95. ncbi Chromosomal localization of ceruloplasmin and transferrin genes in laboratory rats, mice and in man by hybridization with specific DNA probes
    V S Baranov
    Institute of Obstetric and Gynecology, Academy of Medical Sciences of the USSR, Leningrad
    Chromosoma 96:60-6. 1987
    ..The potential and limitations of the in situ hybridization technique with heterologous DNA probes for gene mapping in mammalian species are discussed...
  96. ncbi Transferrin in the central nervous system of the shiverer mouse myelin mutant
    J R Connor
    Department of Neuroscience and Anatomy, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
    J Neurosci Res 36:501-7. 1993
    ..These data further suggest transferrin mRNA may be constitutively expressed by oligodendrocytes and that the protein expression is regulated at the level of translation...
  97. ncbi The bcl-2 family member, Bcl2a1, maps to mouse chromosome 9 and human chromosome 15
    E Y Lin
    Department of Pathology, Albert Einstein College of Medicine Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, USA
    Mamm Genome 8:293-4. 1997
  98. ncbi Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the retinoblastoma gene
    C Szpirer
    Departement de Biologie Moleculaire, Universite Libre de Bruxelles, Rhode St Genese, Brussels, Belgium
    Oncogene 6:1319-24. 1991
    ..The THRA1/ERBA1 and ERBB2/neu genes are thus included in a synteny group, conserved on rat chromosomes 10 and human chromosome arm 17q...
  99. ncbi Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21
    D S Threadgill
    Department of Veterinary Pathology, Texas A and M University, College Station 77843
    Genomics 11:1143-8. 1991
    ..FIM3, SI, and CP mapped to bovine syntenic group U10, while RAF1 and GPX1 mapped to U12...
  100. ncbi Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain
    E A Malecki
    Department of Pediatrics, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
    J Neurol Sci 170:112-8. 1999
    Hypotransferrinemia (hpx/hpx) is a genetic defect in mice resulting in <1% of normal plasma transferrin (Tf) concentrations; heterozygotes for this mutation (+/hpx) have low circulating Tf concentrations...
  101. ncbi Chromosomal mapping of the host resistance locus to rodent malaria (Plasmodium yoelii) infection in mice
    T Ohno
    Institute for Laboratory Animal Research, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Immunogenetics 53:736-40. 2001
    ..Elucidation of the function of this gene will provide valuable insights into the mechanism of host defense against malaria parasite infection...

Research Grants6

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  2. Molecular Pathways of Iron Detoxification in the Lung
    David Haile; Fiscal Year: 2006
    ..This study will lead to a better understanding of iron dysfunction in diseased lungs. [unreadable] [unreadable]..
  3. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  4. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  6. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..