Trdn

Summary

Gene Symbol: Trdn
Description: triadin
Alias: 2310045H21Rik, EG432451, TDN, triadin, cardiac triadin
Species: mouse

Top Publications

  1. ncbi Molecular cloning and characterization of mouse cardiac triadin isoforms
    C S Hong
    Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong dong, Puk Gu, Kwangju 500 712, South Korea
    Gene 278:193-9. 2001
  2. ncbi Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase
    Demetrios A Arvanitis
    Molecular Biology Division, Center for Basic Research, Foundation for Biomedical Research of the Academy of Athens, Athens, Greece
    Am J Physiol Heart Circ Physiol 293:H1581-9. 2007
  3. ncbi Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle
    Xiaohua Shen
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37864-74. 2007
  4. pmc Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human
    Nathalie Roux-Buisson
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble, France
    Hum Mol Genet 21:2759-67. 2012
  5. pmc Altered stored calcium release in skeletal myotubes deficient of triadin and junctin
    Ying Wang
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 7260, United States
    Cell Calcium 45:29-37. 2009
  6. pmc Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture
    Janos Fodor
    Department of Physiology, University of Debrecen, P O Box 22, Hungary
    J Physiol 586:5803-18. 2008
  7. pmc Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias
    Nagesh Chopra
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:7636-41. 2009
  8. pmc Triadin deletion induces impaired skeletal muscle function
    Sarah Oddoux
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble F 38000, France
    J Biol Chem 284:34918-29. 2009
  9. pmc Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+
    Jose M Eltit
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 285:38453-62. 2010
  10. pmc Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum
    Shilpa Rani
    School of Life Sciences and Systems Biology Research Center, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Mol Cells 39:149-55. 2016

Scientific Experts

  • U Kirchhefer
  • Simona Boncompagni
  • P Kirchhof
  • L Csernoch
  • Jocelyn Laporte
  • Isabelle Marty
  • Paul D Allen
  • Do Han Kim
  • Evangelia G Kranias
  • Julie Brocard
  • Julien Faure
  • Stéphane Vassilopoulos
  • Sarah Oddoux
  • Demetrios A Arvanitis
  • Claudio F Perez
  • Ying Wang
  • Shilpa Rani
  • Sophie Payne
  • Daniela Rossi
  • Feliciano Protasi
  • Vivek P Singh
  • Nathalie Roux-Buisson
  • Dana Kucerova
  • Wen Feng Cai
  • Marco Denegri
  • Pascale Guicheney
  • Marine Cacheux
  • Mathieu Rederstorff
  • Joel Lunardi
  • Jose M Eltit
  • Isaac N Pessah
  • Ying Feng
  • Nagesh Chopra
  • Chunghee Cho
  • Peter Szentesi
  • Jose R Lopez
  • Larry R Jones
  • Anna Buj-Bello
  • Clara Franzini-Armstrong
  • Janos Fodor
  • Xiaohua Shen
  • Sunghee Hong
  • Pradeep Kumar Sreenivasaiah
  • Chang Sik Park
  • Nelo Popal
  • Sean M Davidson
  • Karen McCue
  • Peter J Scambler
  • Matthew J Burney
  • Robert H Anderson
  • Cecilia Paolini
  • Vincenzo Sorrentino
  • Cristina Bencini
  • Stefania Lorenzini
  • Marina Maritati
  • Enrico Pierantozzi
  • Angela Maria Scarcella
  • Francesca Benini
  • Xiaoping Ren
  • Mark Gilbert
  • Kobra Haghighi
  • Xiaoqian Gao
  • Clara F Armstrong
  • Hong Sheng Wang
  • John N Lorenz
  • Keith Jones
  • Sandor Gyorke
  • Jack Rubinstein
  • Venkat R Iyer
  • Stefano Andrea De Simone
  • Florence Kyndt
  • C S Hong
  • Peter Boknik
  • Jeremy Fauconnier
  • Frank U Müller
  • Tracy Pritchard
  • Philippe Durand
  • Nicole Monnier
  • Pierre F Ray
  • Vincent Lucet
  • Pompeo Volpe
  • Pauline Trémeaux
  • Anne Fourest-Lieuvin
  • Wilhelm Schmitz
  • Marek Mát'us
  • Antoine Leenhardt
  • Philippe Mabo
  • Silvia Giuliana Priori
  • Peidong Han
  • Alexander Heinick

Detail Information

Publications25

  1. ncbi Molecular cloning and characterization of mouse cardiac triadin isoforms
    C S Hong
    Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong dong, Puk Gu, Kwangju 500 712, South Korea
    Gene 278:193-9. 2001
    ..In the present study, mouse cardiac triadin cDNAs have been identified by cDNA library screening and RT-PCR...
  2. ncbi Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase
    Demetrios A Arvanitis
    Molecular Biology Division, Center for Basic Research, Foundation for Biomedical Research of the Academy of Athens, Athens, Greece
    Am J Physiol Heart Circ Physiol 293:H1581-9. 2007
    ..The histidine-rich Ca-binding protein (HRC) is an SR component that binds to triadin and may affect Ca release through the ryanodine receptor...
  3. ncbi Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle
    Xiaohua Shen
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37864-74. 2007
    To unmask the role of triadin in skeletal muscle we engineered pan-triadin-null mice by removing the first exon of the triadin gene. This resulted in a total lack of triadin expression in both skeletal and cardiac muscle...
  4. pmc Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human
    Nathalie Roux-Buisson
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble, France
    Hum Mol Genet 21:2759-67. 2012
    ..Based on a candidate gene approach, we focused our investigations on triadin and junctin, two proteins that link RyR2 and CSQ2...
  5. pmc Altered stored calcium release in skeletal myotubes deficient of triadin and junctin
    Ying Wang
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599 7260, United States
    Cell Calcium 45:29-37. 2009
    b>Triadin and junctin are integral sarcoplasmic reticulum membrane proteins that form a macromolecular complex with the skeletal muscle ryanodine receptor (RyR1) but their roles in skeletal muscle calcium homeostasis remain incompletely ..
  6. pmc Altered expression of triadin 95 causes parallel changes in localized Ca2+ release events and global Ca2+ signals in skeletal muscle cells in culture
    Janos Fodor
    Department of Physiology, University of Debrecen, P O Box 22, Hungary
    J Physiol 586:5803-18. 2008
    The 95 kDa triadin (Trisk 95), an integral protein of the sarcoplasmic reticular membrane in skeletal muscle, interacts with both the ryanodine receptor (RyR) and calsequestrin...
  7. pmc Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias
    Nagesh Chopra
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:7636-41. 2009
    ..Although studies suggest that the jSR protein triadin anchors cardiac calsequestrin (Casq2) to RyR2, its contribution to E-C coupling remains unclear...
  8. pmc Triadin deletion induces impaired skeletal muscle function
    Sarah Oddoux
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble F 38000, France
    J Biol Chem 284:34918-29. 2009
    b>Triadin is a multiple proteins family, some isoforms being involved in muscle excitation-contraction coupling, and some having still unknown functions...
  9. pmc Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+
    Jose M Eltit
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 285:38453-62. 2010
    ..To understand this mechanism, we study here how triadin alters [Ca(2+)](rest), Ca(2+) release, and Ca(2+) entry pathways using a combination of Ca(2+) microelectrodes, ..
  10. pmc Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum
    Shilpa Rani
    School of Life Sciences and Systems Biology Research Center, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Mol Cells 39:149-55. 2016
    ..CSQ) and histidine-rich Ca(2+) binding protein (HRC) are known to bind the charged luminal region of triadin (TRN) and thus directly or indirectly regulate ryanodine receptor 2 (RyR2) activity...
  11. pmc A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development
    Sophie Payne
    Developmental Biology of Birth Defects Section, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Dev Biol 405:82-95. 2015
    ..This work therefore reveals the importance of CHD7 in the cardiogenic mesoderm for multiple processes during cardiovascular development. ..
  12. doi Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulum
    Daniela Rossi
    Department of Molecular and Developmental Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Biochem J 458:407-17. 2014
    ..of a large multiprotein complex containing the RyR (ryanodine receptor) and additional proteins, including triadin and calsequestrin...
  13. pmc Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein
    Vivek P Singh
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH
    J Am Heart Assoc 2:e000460. 2013
    ..However, the precise mechanisms affecting SR function and leading to arrhythmias remain elusive...
  14. doi Viral gene transfer rescues arrhythmogenic phenotype and ultrastructural abnormalities in adult calsequestrin-null mice with inherited arrhythmias
    Marco Denegri
    Molecular Cardiology, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy
    Circ Res 110:663-8. 2012
    ..The decrease of CASQ2 is associated with a reduction in the levels of Triadin (TrD) and Junctin (JnC), two proteins that form, with CASQ2 and RyR2, a macromolecular complex devoted to control ..
  15. pmc Caveolin 3 is associated with the calcium release complex and is modified via in vivo triadin modification
    Stéphane Vassilopoulos
    INSERM U836, Grenoble Institut des Neurosciences, Equipe Muscle et Pathologies, Grenoble, France
    Biochemistry 49:6130-5. 2010
    The triadin isoforms Trisk 95 and Trisk 51 are both components of the skeletal muscle calcium release complex...
  16. pmc Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion
    Wen Feng Cai
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0575, USA
    Cardiovasc Res 94:333-41. 2012
    Junctin and triadin are calsequestrin-binding proteins that regulate sarcoplasmic reticulum (SR) Ca(2+) release by interacting with the ryanodine receptor...
  17. doi Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes
    Dana Kucerova
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Munster, Germany
    Am J Physiol Heart Circ Physiol 302:H2008-17. 2012
    Calsequestrin (CSQ) is a Ca(2+) storage protein that interacts with triadin (TRN), the ryanodine receptor (RyR), and junctin (JUN) to form a macromolecular tetrameric Ca(2+) signaling complex in the cardiac junctional sarcoplasmic ..
  18. pmc Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis
    Simona Boncompagni
    DNI Department of Neuroscience and Imaging, CeSI Center for Research on Ageing, University of G d Annunzio, Chieti, Italy
    PLoS ONE 7:e39962. 2012
    b>Triadin (Tdn) and Junctin (Jct) are structurally related transmembrane proteins thought to be key mediators of structural and functional interactions between calsequestrin (CASQ) and ryanodine receptor (RyRs) at the junctional ..
  19. pmc Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy
    Mathieu Rederstorff
    Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, Strasbourg, France
    PLoS ONE 6:e23094. 2011
    ....
  20. pmc SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart
    Ying Feng
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Dev Cell 16:528-38. 2009
    ..profiles in the SRp38(-/-) embryonic heart revealed a defect in processing of the pre-mRNA encoding cardiac triadin, a protein that functions in regulation of Ca(2+) release from the sarcoplasmic reticulum during excitation-..
  21. pmc AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis
    Anna Buj-Bello
    Department of Neurobiology and Genetics, INSERM U596, CNRS UMR 7104, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch, France
    Hum Mol Genet 17:2132-43. 2008
    ..This study provides a proof-of-principle that local delivery of an AAV vector expressing myotubularin can improve the motor capacities of XLMTM muscle and represents a novel approach to study myotubularin function in skeletal muscle...
  22. ncbi Triadin is a critical determinant of cellular Ca cycling and contractility in the heart
    Uwe Kirchhefer
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Munster, Munster, Germany
    Am J Physiol Heart Circ Physiol 293:H3165-74. 2007
    b>Triadin is involved in the regulation of cardiac excitation-contraction coupling...
  23. ncbi Stress and high heart rate provoke ventricular tachycardia in mice expressing triadin
    Paulus Kirchhof
    Department of Cardiology and Angiology, Hospital of the University of Münster, Germany
    J Mol Cell Cardiol 42:962-71. 2007
    ..These proteins regulate sarcoplasmic Ca(2+) release in close conjunction with two accessory proteins, triadin and junctin. Based on data from cardiomyocytes, we hypothesized that enhanced triadin expression could cause VT...
  24. ncbi Complementary DNA cloning, genomic characterization and expression analysis of a mammalian gene encoding histidine-rich calcium binding protein
    Sunghee Hong
    Department of Life Science, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1727:188-96. 2005
    ..Collectively, our study provides comprehensive information about the structure and expression of the mammalian HRC gene, together with the comparative expression data of the related SR genes...
  25. ncbi Altered function in atrium of transgenic mice overexpressing triadin 1
    Uwe Kirchhefer
    Institut fur Pharmakologie und Toxikologie, Westfalische Wilhelms Universitat, 48149 Munster, Germany
    Am J Physiol Heart Circ Physiol 283:H1334-43. 2002
    ..of SR proteins and contractility in atria of 3-, 6-, and 18-wk-old transgenic mice overexpressing canine cardiac triadin 1 under control of the alpha-myosin heavy chain (MHC) promoter...