Traf6

Summary

Gene Symbol: Traf6
Description: TNF receptor-associated factor 6
Alias: 2310003F17Rik, AI851288, C630032O20Rik, TNF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, RING-type E3 ubiquitin transferase TRAF6
Species: mouse

Top Publications

  1. pmc Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
    Wei Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:1858-66. 2008
  2. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
  3. pmc MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling
    Jian Liang
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA
    J Exp Med 207:2959-73. 2010
  4. pmc Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7
    Stephane Daffis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 5:e1000607. 2009
  5. ncbi Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:243-9. 2005
  6. doi Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 283:6783-9. 2008
  7. pmc CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases
    Young In Kim
    The Children s Foundation Research Center at Le Bonheur Children s Medical Center, and Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap Street, Memphis, TN 38103, USA
    J Biol Chem 283:15258-70. 2008
  8. pmc TRAF6 mediates IL-1β/LPS-induced suppression of TGF-β signaling through its interaction with the type III TGF-β receptor
    Seunghwan Lim
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 7:e32705. 2012
  9. pmc Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) play essential roles in the C-type lectin receptor signaling in response to Candida albicans infection
    Sara Gorjestani
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 287:44143-50. 2012
  10. ncbi ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
    Atsushi Matsuzawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Immunol 6:587-92. 2005

Research Grants

Scientific Experts

  • Nacksung Kim
  • Noula Shembade
  • Liusheng He
  • Chong Shan Shi
  • Takashi Kobayashi
  • Megumi Funakoshi-Tago
  • Matthew D Petroski
  • Bruce S Hostager
  • Marie W Wooten
  • CARLOS SUBAUSTE
  • A Nykjaer
  • Esther Lutgens
  • Emmanuel Derudder
  • Hans Hacker
  • J Inoue
  • Derek Abbott
  • Yumiko Imai
  • Yongwon Choi
  • Taishin Akiyama
  • Bryant G Darnay
  • Shizuo Akira
  • Betty Lamothe
  • Jin Gohda
  • Matthew C Walsh
  • Xiaoxia Li
  • Gail A Bishop
  • Carolyn G King
  • Mitsuru Matsumoto
  • Atsushi Matsuzawa
  • Masahiro Yamamoto
  • Thangiah Geetha
  • Taro Kawai
  • Caini Liu
  • Pedro J Cejas
  • Shintaro Sato
  • Hiroyasu Konno
  • Laurence A Turka
  • Alejandro D Campos
  • Junwen Qin
  • Kwiyeom Yoon
  • Nobutaka Suzuki
  • Hiroyasu Nakano
  • Hiroshi Takayanagi
  • Pradyut K Paul
  • Seunghwan Lim
  • Akinori Takaoka
  • Sara Gorjestani
  • Kenya Honda
  • Adrian Tun-Kyi
  • Kelly M Arcipowski
  • A Phillip West
  • Xin Lin
  • Sankar Ghosh
  • A Naito
  • Shutao Xie
  • Jian Liang
  • Wen Chen Yeh
  • Jing Wang
  • Baukje M Elzinga
  • Nelson C Di Paolo
  • Richard A Flavell
  • Asuka Naito
  • Estabelle Ang
  • Ji Young Kim
  • Stephane Daffis
  • Susie S Mikkelsen
  • Laura L Stunz
  • Wei Lei Yang
  • M A Lomaga
  • Erika L Pearce
  • Fuminori Tokunaga
  • Justin Hartupee
  • Jin Hou
  • Lana Hur
  • K Yoon
  • Mizuho Hasegawa
  • Alessandro Sorrentino
  • Shuting Bai
  • Wei Jin
  • Fabiana S Machado
  • Ryoko Yoshida
  • Young In Kim
  • Claudia Orelio
  • Motozo Yamashita
  • Shunbin Ning
  • Emre E Turer
  • Un Hwan Ha
  • Marjo M P C Donners
  • Steven L Teitelbaum
  • Daisuke Ohshima

Detail Information

Publications127 found, 100 shown here

  1. pmc Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
    Wei Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 118:1858-66. 2008
    ..of osteoclastic signaling is incompletely understood, but ubiquitination of TNF receptor-associated factor 6 (TRAF6) has recently been shown to be important in mediating this process...
  2. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
  3. pmc MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling
    Jian Liang
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA
    J Exp Med 207:2959-73. 2010
    ..kinase (JNK) and NF-κB activity by removing ubiquitin moieties from proteins, including TRAF2, TRAF3, and TRAF6. MCPIP1-deficient mice spontaneously developed fatal inflammatory syndrome...
  4. pmc Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7
    Stephane Daffis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 5:e1000607. 2009
    ....
  5. ncbi Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:243-9. 2005
    ..We also provide evidence that IRF-5 interacts with and is activated by MyD88 and TRAF6, and that TLR activation results in the nuclear translocation of IRF-5 to activate cytokine gene transcription...
  6. doi Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 283:6783-9. 2008
    ..The increase in Lys63 chains was attributed in part to diminished activity of the TRAF6-interacting the Lys63-deubiquitinating enzyme (DUB), cylindromatosis tumor suppressor (CYLD)...
  7. pmc CpG DNA prevents liver injury and shock-mediated death by modulating expression of interleukin-1 receptor-associated kinases
    Young In Kim
    The Children s Foundation Research Center at Le Bonheur Children s Medical Center, and Department of Pediatrics, University of Tennessee Health Science Center, 50 N Dunlap Street, Memphis, TN 38103, USA
    J Biol Chem 283:15258-70. 2008
    ....
  8. pmc TRAF6 mediates IL-1β/LPS-induced suppression of TGF-β signaling through its interaction with the type III TGF-β receptor
    Seunghwan Lim
    Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 7:e32705. 2012
    ..b>TRAF6, a key molecule in IL-1β signaling, mediates this suppressive effect through interaction with the type III TGF-β ..
  9. pmc Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) play essential roles in the C-type lectin receptor signaling in response to Candida albicans infection
    Sara Gorjestani
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 287:44143-50. 2012
    Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGFβ-activated kinase 1 (TAK1) are considered as key intermediates in Toll-like receptor (TLR) signaling...
  10. ncbi ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
    Atsushi Matsuzawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Immunol 6:587-92. 2005
    ..intracellular reactive oxygen species, which was required for the formation of a complex of the adaptor molecule TRAF6 and ASK1 and subsequent activation of the ASK1-p38 pathway...
  11. pmc Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons
    Xiang Zhou
    Department of Cell Biology, Duke University Medical School, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:5842-7. 2007
    ..These results and additional studies suggest that Ulk1/2 proteins regulate filopodia extension and neurite branching during sensory axon outgrowth, probably through regulating TrkA receptor trafficking and signaling...
  12. ncbi NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6
    Mutsumi Kanamori
    Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    FEBS Lett 532:241-6. 2002
    ..We identified and confirmed that Act1 interacts with tumor necrosis factor receptor-associated factor 6 (TRAF6); notably, Act1 binds to TRAF6 only among TRAF family proteins...
  13. ncbi The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
    Yunfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 282:39-48. 2007
    ..of this LIM protein family, Limd1, is uniquely up-regulated during osteoclast differentiation and interacts with Traf6, a critical cytosolic regulator of RANK-L-regulated osteoclast development...
  14. pmc Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo
    Claudia Orelio
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 112:4895-904. 2008
    ..Our results suggest that IL-1 is an important homeostatic regulator at the earliest time of HSC development, acting to limit the differentiation of some HSCs along the myeloid lineage...
  15. pmc The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway
    L Sanz
    Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    EMBO J 19:1576-86. 2000
    ..that the inhibition of the aPKCs or the down-regulation of p62 severely abrogates NF-kappaB activation by IL-1 and TRAF6, suggesting that both proteins are critical intermediaries in this pathway...
  16. ncbi Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
    Nobutaka Suzuki
    Amgen Institute, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 620 University Avenue, Suite 706, Toronto, Ontario M5G 2C1, Canada
    Nature 416:750-6. 2002
    ..Intracellular signalling mechanisms mediated by TIRs are similar, with MyD88 (refs 5-8) and TRAF6 (refs 9, 10) having critical roles...
  17. ncbi IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex
    Ichiro Nakamura
    Department of Orthopedic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 168:5103-9. 2002
    Targeted disruption of either c-Src or TNFR-associated factor 6 (TRAF6) in mice causes osteoclast dysfunction and an osteopetrotic phenotype, suggesting that both molecules play important roles in osteoclastic bone resorption...
  18. ncbi Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis
    Zhiyuan Zhang
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 171:3620-6. 2003
    ..GST pull down experiments indicated that the association of SHP-1 with TRAF6 is mediated by SHP-1 lacking the two Src homology 2 domains...
  19. ncbi Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling
    Yuko Maezawa
    Department of Allergy and Clinical Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 176:1013-8. 2006
    ..We also found that IL-25R-mediated NF-kappaB activation was inhibited by the expression of dominant negative TRAF6 but not of dominant negative TRAF2...
  20. doi Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis
    Baukje M Elzinga
    Signal Transduction Laboratory, Biochemistry Department, University College Cork, Cork, Ireland
    J Biol Chem 284:1394-409. 2009
    ..study, we report the characterization of a highly conserved tumor necrosis factor receptor-associated factor-6 (TRAF6) consensus-binding site within the hydrophilic loop domain of presenilin-1 (PS-1)...
  21. pmc The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity
    Ji Young Kim
    Laboratory of Molecular Growth Regulation, Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:2131-40. 2009
    ..Together, p62 may provide a mechanism by which to control excessive inflammatory responses after macrophage activation...
  22. pmc ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
    E Kopp
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute HHMI, Yale University School of Medicine, New Haven, Connecticut 06520 USA
    Genes Dev 13:2059-71. 1999
    ..We report the identification and characterization of a novel intermediate in these signaling pathways that bridges TRAF6 to MEKK-1...
  23. ncbi Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
    T Ishida
    Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108, Japan
    J Biol Chem 271:28745-8. 1996
    ..A cDNA encoding a putative signal transducer, designated TRAF6, has been molecularly cloned...
  24. pmc TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    Genes Dev 13:1015-24. 1999
    ..Here we report that mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function...
  25. ncbi Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
    A Naito
    Department of Oncology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genes Cells 4:353-62. 1999
    b>TRAF6, a member of the tumour necrosis factor receptor-associated factor family, was first identified as a transducer of CD40 and interleukin-1 receptor (IL-1R) signals based on the interaction of TRAF6 with the cytoplasmic tail of CD40 ..
  26. pmc Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction
    R Schwandner
    Tularik Incorporated, South San Francisco, California 94080, USA
    J Exp Med 191:1233-40. 2000
    ..In embryonic fibroblasts (EFs) derived from TRAF6 knockout mice, IL-17 failed to activate the IkappaB kinases (IKKs) and JNK...
  27. pmc Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis
    N Kobayashi
    Department of Hematology, Research Institute, International Medical Center of Japan, Shinjuku ku, Tokyo 162 8655, Japan
    EMBO J 20:1271-80. 2001
    ..These kinases are thought to be activated by tumor necrosis factor receptor-associated factor 6 (TRAF6). However, molecular mechanisms by which TRAF6 activates various downstream kinases remain to be elucidated...
  28. pmc The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells
    Cory Ahonen
    Department of Microbiology and Immunology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Nat Immunol 3:451-6. 2002
    ..Through disruption of the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-binding site within the CD40 cytoplasmic domain, we selectively ablated affinity maturation and the generation of ..
  29. ncbi Distinct molecular mechanism for initiating TRAF6 signalling
    Hong Ye
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nature 418:443-7. 2002
    Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family member that participates in signal transduction of both the TNF receptor (TNFR) superfamily and the interleukin-1 receptor (IL-1R)/Toll-like ..
  30. ncbi A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function
    Allison P Armstrong
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 277:44347-56. 2002
    ..In contrast, the interaction of RANK with TRAF6 is absolutely required for the proper formation of cytoskeletal structures and functional resorptive activity of ..
  31. ncbi Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling
    Hiroshi Takatsuna
    Division of Cellular and Molecular Biology, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 278:12144-50. 2003
    Tumor necrosis factor receptor-associated factor 6 (TRAF6) transduces signals from members of the Toll/interleukin-1 (IL-1) receptor family by interacting with IL-1 receptor-associated kinase-1 (IRAK-1) after IRAK-1 is released from the ..
  32. ncbi TRAF6 and C-SRC induce synergistic AP-1 activation via PI3-kinase-AKT-JNK pathway
    Megumi Funakoshi-Tago
    Department of Biochemistry, Kyoritsu College of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Eur J Biochem 270:1257-68. 2003
    ..also revealed that c-Src-induced AP-1 activation was enhanced synergistically by the coexpression of TNF receptor associated factor 6 (TRAF6)...
  33. ncbi Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling
    Bruce S Hostager
    Department of Pediatrics, Interdisciplinary Program in Immunology, University of Iowa, Iowa City 52242, USA
    J Biol Chem 278:45382-90. 2003
    ..Finally, we show that TRAF2 and TRAF6 have overlapping functions in CD40-mediated NF-kappaB activation and CD80 up-regulation...
  34. ncbi TRAF6 is a critical factor for dendritic cell maturation and development
    Takashi Kobayashi
    Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
    Immunity 19:353-63. 2003
    ..Several signaling pathways associated with each family utilize the adapter molecule, TRAF6, but its role in DCs is unclear...
  35. ncbi Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like re
    Shintaro Sato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Immunol 171:4304-10. 2003
    ..TNF receptor-associated factor (TRAF)6 interacted with TRIF through the TRAF domain of TRAF6 and TRAF6-binding motifs found in the N-terminal portion of TRIF...
  36. ncbi Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
    Qiaojia Huang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Immunol 5:98-103. 2004
    ..complex of MyD88, IL-1R-associated protein kinase (IRAK) and tumor necrosis factor receptor-associated factor 6 (TRAF6), which is believed to function 'upstream' of the cascades of IkappaB kinase (IKK) and nuclear factor-kappaB (NF-..
  37. pmc Epstein-Barr virus latent membrane protein 1 activation of NF-kappaB through IRAK1 and TRAF6
    Micah Luftig
    Program in Virology, Department of Microbiology and Molecular Genetics, Harvard Medical School, Channing Laboratory Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115
    Proc Natl Acad Sci U S A 100:15595-600. 2003
    ..We now use cells lacking expression of TRAF2, TRAF5, TRAF6, IKKalpha, IKKbeta, IKKgamma, TAB2, IL-1 receptor-associated kinase (IRAK)1, or IRAK4 to assess their roles in ..
  38. ncbi The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    Lijun Sun
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 14:289-301. 2004
    ..Here we present evidence that TRAF6 ubiquitin ligase and TAK1 protein kinase mediate IKK activation by BCL10 and MALT1...
  39. ncbi Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling
    Jin Gohda
    Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 173:2913-7. 2004
    ..However, the precise role of TRAF6 in signaling from individual TLRs has not been appropriately addressed...
  40. ncbi Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    Taro Kawai
    ERATO, Akira Innate Immunity Program, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 5:1061-8. 2004
    ..Furthermore, the adaptor molecule TRAF6 also bound and activated IRF7. Ubiquitin ligase activity of TRAF6 was required for IRF7 activation...
  41. pmc Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 101:15416-21. 2004
    ..We provide evidence that this complex also involves IRAK4 and TRAF6 and provides the foundation for the TLR9-dependent activation of the IFN genes...
  42. ncbi Dependence of self-tolerance on TRAF6-directed development of thymic stroma
    Taishin Akiyama
    Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Science 308:248-51. 2005
    ..Engraftment of thymic stroma of TRAF6(-/-) embryos into athymic nude mice induced autoimmunity...
  43. ncbi The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
    ..1/p62 is a scaffolding protein with several interaction modules that include a PB1 dimerization domain, a TRAF6 (tumor necrosis factor receptor-associated factor 6) binding site, and a ubiquitin-associating (UBA) domain...
  44. ncbi The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I
    Simon Rothenfusser
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 175:5260-8. 2005
    ..We propose that Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering dsRNA from RIG-I...
  45. ncbi Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling
    Thangiah Geetha
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    Mol Cell 20:301-12. 2005
    ..TrkA is a substrate of tumor necrosis factor receptor-associated factor 6 (TRAF6), and expression of K63R mutant ubiquitin or an absence of TRAF6 abrogated TrkA polyubiquitination and ..
  46. pmc TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor
    Thangiah Geetha
    Department of Biological Sciences and Program in Cell and Molecular Biosciences, Auburn University, Auburn, AL, USA
    EMBO J 24:3859-68. 2005
    b>TRAF6 is an E3 ubiquitin ligase that mediates signaling from members of the tumor necrosis factor and Toll-like receptor superfamilies, including the p75 neurotrophin receptor...
  47. ncbi Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    Hans Hacker
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 439:204-7. 2006
    ..receptor-associated factor 3 (TRAF3) as a new component of TIR signalling complexes that is recruited along with TRAF6. Using myeloid cells from TRAF3- and TRAF6-deficient mice, we show that TRAF3 is essential for the induction of ..
  48. ncbi Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
    Yaya Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Nat Immunol 7:139-47. 2006
    Tumor necrosis factor receptor-associated factor 6 (TRAF6) is critical for mediating Toll-like receptor (TLR)-interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate ..
  49. pmc TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB
    Noriyuki Uemura
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Biol Chem 281:7863-72. 2006
    ..Genetic analysis has revealed that tumor necrosis factor receptor-associated factor 6 (TRAF6) is an indispensable intermediate of LMP1 signaling leading to activation of both NF-kappaB and JNK...
  50. ncbi The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4
    Wei Dong
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China
    J Biol Chem 281:26029-40. 2006
    ..that recruits BCL10 to the TLR4 signaling complex and mediates signaling to NF-kappaB through the BCL10-MALT1-TRAF6-TAK1 cascade...
  51. ncbi Rapid CD40-mediated rescue from CD95-induced apoptosis requires TNFR-associated factor-6 and PI3K
    Rebecca J Benson
    Medical Scientist Training Program and Immunology Graduate Program, University of Iowa and Veterans Affairs Medical Center, Iowa City 52245, USA
    Eur J Immunol 36:2535-43. 2006
    ..In contrast, CD40 rescue was completely abrogated in TRAF6-deficient B cells, which showed reduced activation of Akt in response to CD40 engagement...
  52. ncbi TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
    Carolyn G King
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:1088-92. 2006
    b>TRAF6 has a key role in the regulation of innate immune responses by mediating signals from both TNF receptor and interleukin-1 receptor/Toll-like receptor superfamilies...
  53. ncbi TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells
    Andreas Zirlik
    Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 27:1101-7. 2007
    ..This study investigated the involvement of tumor necrosis factor receptor-associated factors (TRAFs) in CD40 signaling in endothelial cells (ECs) and their expression in atheromata and cells involved in atherogenesis...
  54. pmc Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains
    Derek W Abbott
    Department of Pathology, Case Western Reserve University School of Medicine, Room 5123 Wolstein Research Building, Cleveland, OH 44106, and Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mol Cell Biol 27:6012-25. 2007
    ..This ubiquitination is partially accomplished through the E3 ubiquitin ligase TRAF6. TRAF6 is activated by NOD2, and this activation is lost with a major Crohn's disease-associated NOD2 allele, ..
  55. pmc TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation
    Betty Lamothe
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Box 143, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Biochem Biophys Res Commun 359:1044-9. 2007
    Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-kappaB (RANK), plays an essential role in governing the formation of multi-nucleated osteoclasts...
  56. ncbi Characteristics and biological functions of TRAF6
    Jun ichiro Inoue
    Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Adv Exp Med Biol 597:72-9. 2007
    b>TRAF6 is divergent from other members of the TRAF family. Therefore, TRAF6 was expected to play physiological roles distinct from those of other TRAFs...
  57. pmc Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL 33136, USA
    EMBO J 26:3910-22. 2007
    ..and LPS-mediated IKK and JNK activation is elevated and persistent owing to enhanced ubiquitination of RIP1 and TRAF6. Furthermore, in the absence of TAX1BP1, A20 is impaired in RIP1 binding, deubiquitination of TRAF6 and inhibition ..
  58. ncbi A novel mechanism for TNFR-associated factor 6-dependent CD40 signaling
    Sarah L Rowland
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80262, USA
    J Immunol 179:4645-53. 2007
    ..To better define the roles of TRAF2 and TRAF6 in CD40 signaling, we used somatic cell gene targeting to generate TRAF-deficient mouse B cell lines. A20...
  59. ncbi NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2
    Yibin Yang
    Department of Pathology, Case Western University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 282:36223-9. 2007
    ..We also demonstrate a requirement for the E2-conjugating enzyme Ubc13, the E3 ubiquitin ligase Traf6, and the ubiquitin-activated kinase Tak1 in Nod2-mediated NF-kappaB activation...
  60. doi The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling
    Marjo M P C Donners
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Blood 111:4596-604. 2008
    ..and in CD40(-/-) mice that contained a CD40 transgene with or without mutations at the CD40-TRAF2,3&5, TRAF6, or TRAF2,3,5&6 binding sites...
  61. doi Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    ..We show that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI...
  62. doi TRAF6 is a critical signal transducer in IL-33 signaling pathway
    Megumi Funakoshi-Tago
    Department of Biochemistry, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Cell Signal 20:1679-86. 2008
    ..protein (MCP)-1, MCP-3 and IL-6 expression was significantly inhibited in TNF receptor-associated Factor 6 (TRAF6)-deficient MEFs...
  63. pmc The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL
    Betty Lamothe
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 283:24871-80. 2008
    b>TRAF6, a crucial adaptor molecule in innate and adaptive immunity, contains three distinct functional domains...
  64. pmc Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
    Atsushi Matsuzawa
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 321:663-8. 2008
    ..This two-stage signaling mechanism may apply to other innate immune receptors, accounting for spatial and temporal separation of MAPK and IKK signaling...
  65. pmc TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1
    Shunbin Ning
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Biol 28:6536-46. 2008
    ..Biol. 27:2910-2918, 2007). In this study, with the use of small interfering RNA and TNFR-associated factor 6 (TRAF6) knockout cells, we first show that TRAF6 and its E3 ligase activity are required for LMP1-stimulated IRF7 ..
  66. doi The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner
    Alessandro Sorrentino
    Ludwig Institute for Cancer Research, Rudbeck Laboratory, Uppsala University, Sweden, Dag Hammarskjoldsv 20, SE 75185 Uppsala, Sweden
    Nat Cell Biol 10:1199-207. 2008
    ..However, the molecular mechanisms for its activation are unknown. Here we report that the ubiquitin ligase (E3) TRAF6 interacts with a consensus motif present in TbetaRI...
  67. pmc Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts
    Shuting Bai
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:30861-7. 2008
    Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with the cytoplasmic domain of receptor activator of NF-kappaB (RANK) and is an essential component of the signaling complex mediating osteoclastogenesis...
  68. doi The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance
    Taishin Akiyama
    Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Immunity 29:423-37. 2008
    ..or CD40 on fetal thymic stroma in vitro induced mTEC development in a tumor necrosis factor-associated factor 6 (TRAF6)-, NF-kappaB inducing kinase (NIK)-, and IkappaB kinase beta (IKKbeta)-dependent manner...
  69. pmc TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta
    Motozo Yamashita
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cell 31:918-24. 2008
    ..We report here that TRAF6 is specifically required for the Smad-independent activation of JNK and p38, and its carboxyl TRAF homology domain ..
  70. pmc TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway
    Ryoko Yoshida
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 283:36211-20. 2008
    ..b>TRAF6 and the downstream kinase TAK1 have been shown to be essential for the production of proinflammatory cytokines ..
  71. pmc TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008
    The adapter protein TRAF6 is critical for mediating signal transduction from members of the IL-1R/TLR and TNFR superfamilies...
  72. doi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO...
  73. pmc TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA
    Hiroyasu Konno
    Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e5674. 2009
    ..During such TLR signaling, TNF receptor-associated factor 6 (TRAF6) is essential for the activation of NF-kappaB and the production of type I IFN...
  74. pmc The E3 ligase TRAF6 regulates Akt ubiquitination and activation
    Wei Lei Yang
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1134-8. 2009
    ..b>TRAF6 was found to be a direct E3 ligase for Akt and was essential for Akt ubiquitination, membrane recruitment, and ..
  75. pmc Act1, a U-box E3 ubiquitin ligase for IL-17 signaling
    Caini Liu
    Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Sci Signal 2:ra63. 2009
    ..complex, Act1 mediated the lysine-63-linked ubiquitination of tumor necrosis factor receptor-associated factor 6 (TRAF6), a component of IL-17-mediated signaling...
  76. pmc Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile
    Esther Lutgens
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht 6200 MD, Netherlands
    J Exp Med 207:391-404. 2010
    ..Absence of CD40-TRAF6 but not CD40-TRAF2/3/5 signaling abolishes atherosclerosis and confers plaque fibrosis in Apoe(-/-) mice...
  77. pmc TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2
    Pedro J Cejas
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 115:4750-7. 2010
    ..report that CD4(+) T cells lacking the molecular adaptor tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) exhibit a specific increase in Th17 differentiation in vivo and in vitro...
  78. doi TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 3:ra42. 2010
    ..We found that tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-mediated, Lys(63) (K63)-linked ubiquitination of Beclin-1 is critical for TLR4-triggered autophagy in macrophages...
  79. pmc Molecular mechanisms of TNFR-associated factor 6 (TRAF6) utilization by the oncogenic viral mimic of CD40, latent membrane protein 1 (LMP1)
    Kelly M Arcipowski
    Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 286:9948-55. 2011
    ..We have previously shown that LMP1 and CD40 use TRAFs 1, 2, 3, and 5 differently. TRAF6 is important for CD40 signaling, but the role of TRAF6 in LMP1 signaling in B cells is not clear...
  80. pmc TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
    A Phillip West
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 472:476-80. 2011
    ..response involves translocation of a TLR signalling adaptor, tumour necrosis factor receptor-associated factor 6 (TRAF6), to mitochondria, where it engages the protein ECSIT (evolutionarily conserved signalling intermediate in Toll ..
  81. pmc Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity
    Adrian Tun-Kyi
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:733-41. 2011
    ..Given the critical role of aberrant activation of IRAK1 and type I interferons in various immune diseases, controlling IRAK1 activation via inhibition of Pin1 may represent a useful therapeutic approach...
  82. pmc The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms
    Pradyut K Paul
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Mol Cell Biol 32:1248-59. 2012
    ..Here we unveiled the role of tumor necrosis factor receptor-associated factor 6 (TRAF6), a unique E3 ubiquitin ligase and adaptor protein, in starvation-induced muscle atrophy...
  83. ncbi The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching
    Haifa Jabara
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunity 17:265-76. 2002
    ..switching in B cells, we introduced wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice...
  84. ncbi Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS
    M A Lomaga
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada M5S 2S2
    J Neurosci 20:7384-93. 2000
    ..We report here that targeted deletion of traf6 greatly increases the frequency of failure of neural tube closure and exencephaly in traf6 (-/-) mice...
  85. pmc TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
    Asuka Naito
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 99:8766-71. 2002
    Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) is an adapter protein that links signals from members of the TNFR superfamily and Toll/IL-1 receptor family to activation of transcription factors NFkappaB and AP-1...
  86. ncbi Expression of TNF-receptor-associated factor genes in murine tooth development
    Atsushi Ohazama
    Department of Craniofacial Development, GKT Dental Institute, King s College London, Guy s Hospital, Floor 28, Guy s Tower, London Bridge, London SE1 9RT, UK
    Gene Expr Patterns 3:127-9. 2003
    ..We carried out comparative in situ hybridization analysis of five Traf genes Traf1, Traf2, Traf3, Traf4 and Traf6 during murine odontogenesis from the formation of the epithelial thickening to the early bell stage...
  87. ncbi Myeloid differentiation factor 88-dependent post-transcriptional regulation of cyclooxygenase-2 expression by CpG DNA: tumor necrosis factor-alpha receptor-associated factor 6, a diverging point in the Toll-like receptor 9-signaling
    Seon Ju Yeo
    Children s Foundation Research Center at Le Bonheur Children s Medical Center, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Biol Chem 278:40590-600. 2003
    ..However, overexpression of DN-IRAK-1 or DN-TRAF6 resulted in substantial, but not complete, inhibition of the CpG DNA-induced COX2-3'-UTR-luciferase activity...
  88. ncbi Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism
    Alok C Bharti
    Cytokine Research Section, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:6065-76. 2004
    ..Suppression of interaction of RANK with TRAF6 by TRAF6-binding peptide abrogated the anti-proliferative effects of RANKL, suggesting the critical role of TRAF6...
  89. ncbi Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability
    Huabao Xiong
    Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Biol Chem 279:43675-83. 2004
    ..We now report that MAST205 forms a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappaB activation...
  90. pmc TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii
    Nicola J Mason
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Infect Immun 72:5662-7. 2004
    ..The adaptor molecule TRAF6 is involved in TLR signaling pathways and associates with serine/threonine kinases involved in the activation of ..
  91. pmc RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis
    Jin Gohda
    Division of Cellular and Molecular Biology, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Shirokane dai, Minato ku, Tokyo, Japan
    EMBO J 24:790-9. 2005
    RANK and CD40 activate NF-kappaB and MAPKs to similar levels via TRAF6. Even though overexpression of TRAF6 results in osteoclast formation, RANK but not CD40 promotes osteoclastogenesis...
  92. ncbi p75NTR--live or let die
    Anders Nykjaer
    Department of Medical Biochemistry, Ole Worms Allé Building 170, Aarhus University, DK 8000C Aarhus, Denmark
    Curr Opin Neurobiol 15:49-57. 2005
    ..Here, we review recent progress in delineating the molecular networks that enable p75(NTR) to dictate life and death...
  93. pmc Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis
    Nacksung Kim
    Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Korea
    J Exp Med 202:589-95. 2005
    ..Hence, the current paradigm holds that TRANCE-RANK interaction and subsequent signaling via TRAF6 are essential for the generation of functional osteoclasts...
  94. ncbi FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling
    Ryuichi Mashima
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 280:41289-97. 2005
    ..In this study we identified and characterized a novel interferon- and LPS-inducible gene, FLN29, which contains a TRAF6-related zinc finger motif and TRAF family member-associated NF-kappaB activator-related sequences...
  95. ncbi Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages
    Sushil Kumar Pathak
    Department of Chemistry, Bose Institute, 93 1 Acharya Prafulla Chandra Road, Kolkata 700009, India
    J Biol Chem 280:42794-800. 2005
    ..Man-LAM inhibits IL-1 receptor-associated kinase (IRAK)-TRAF6 interaction as well as IkappaB-alpha phosphorylation...
  96. ncbi TRAF6 regulates cell fate decisions by inducing caspase 8-dependent apoptosis and the activation of NF-kappaB
    Liusheng He
    Flow Cytometry Section, Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:11235-49. 2006
    Tumor necrosis factor receptor-associated factor 6 (TRAF6) functions as an adaptor, positively regulating the NF-kappaB pathway. Here we report a new function of human TRAF6, the direct stimulation of apoptosis...
  97. ncbi TNF-receptor associated factor 6-deficient fibroblast is sensitive to the TNF-alpha-induced cell death: involvement of reactive oxygen species
    Daiju Ichikawa
    Department of Biochemistry, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Biochem Biophys Res Commun 351:93-8. 2006
    Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) has mainly been involved in signaling from CD40 and IL-1 receptor family...
  98. ncbi Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin
    Yoko Hamazaki
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Immunol 8:304-11. 2007
    ..for Aire(+) mTECs, whose development crucially required NF-kappaB-inducing kinase and the adaptor molecule TRAF6. Our results suggest that Aire(+) mTECs represent terminally differentiated cells in a unique lineage arising ..
  99. ncbi Role of IRAK4 and IRF3 in the control of intracellular infection with Chlamydia pneumoniae
    Christian Trumstedt
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobels vag 16, 171 77 Stockholm, Sweden
    J Leukoc Biol 81:1591-8. 2007
    ..TLR-dependent and -independent signals converge in the TNF receptor-associated factor 6 (TRAF6) adaptor, which mediates the activation of NF-kappaBeta...
  100. ncbi Developmental stage-dependent collaboration between the TNF receptor-associated factor 6 and lymphotoxin pathways for B cell follicle organization in secondary lymphoid organs
    Junwen Qin
    Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 179:6799-807. 2007
    ..We investigated the effect of a deficiency of TNFR-associated factor 6 (TRAF6), which activates the classical NF-kappaB pathway, in splenic microenvironment formation...
  101. pmc A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation
    Mizuho Hasegawa
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    EMBO J 27:373-83. 2008
    ..Thus, RICK polyubiquitination links TAK1 to IKK complexes, a critical step in Nod1/Nod2-mediated NF-kappaB activation...

Research Grants3

  1. CD40 Ligand: Therapy for Opportunistic Pathogens and HIV
    CARLOS SUBAUSTE; Fiscal Year: 2004
    ..The mechanisms that mediate this effect will be elucidated. This work will provide crucial information for the evaluation of modulation of CD40L signaling as an approach to immunotherapy in HIV+ individuals. ..
  2. RIP2 kinase's function in Innate Immunity
    Derek Abbott; Fiscal Year: 2007
    ..This initial data was used to help identify the adapter protein, TRAF6, as a phosphorylation substrate of RIP2...
  3. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
    ..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..