Traf3

Summary

Gene Symbol: Traf3
Description: TNF receptor-associated factor 3
Alias: AI528849, CAP-1, CD40bp, CRAF1, LAP1, T-BAM, amn, TNF receptor-associated factor 3, CD40 receptor-associated factor 1, RING-type E3 ubiquitin transferase TRAF3, TRAFAMN
Species: mouse

Top Publications

  1. ncbi TRAF3: a new regulator of type I interferons
    Supriya K Saha
    Department of Microbiology, Immunology and Molecular Genetics, Medical Scientist Training Program, University of California at Los Angeles, Los Angeles, California 90095, USA
    Cell Cycle 5:804-7. 2006
  2. pmc The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
    Sharron A N Brown
    Vascular Biology Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Biochem J 371:395-403. 2003
  3. ncbi Roles of TNF receptor-associated factor 3 in signaling to B lymphocytes by carboxyl-terminal activating regions 1 and 2 of the EBV-encoded oncoprotein latent membrane protein 1
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:5546-55. 2004
  4. pmc Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Exp Med 199:661-71. 2004
  5. pmc Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
    Atsushi Matsuzawa
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 321:663-8. 2008
  6. doi TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
    Sandra Gardam
    Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst NSW 2010, Australia
    Immunity 28:391-401. 2008
  7. pmc Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
    Sivakumar Vallabhapurapu
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Cancer Center, University of California, San Diego, California 93093, USA
    Nat Immunol 9:1364-70. 2008
  8. pmc Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
    Brian J Zarnegar
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E Young Drive East, Los Angeles, California 90095, USA
    Nat Immunol 9:1371-8. 2008
  9. pmc Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunity 27:253-67. 2007
  10. pmc TRAF3 regulates the effector function of regulatory T cells and humoral immune responses
    Jae Hoon Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030
    J Exp Med 211:137-51. 2014

Research Grants

Scientific Experts

  • Hans Hacker
  • Bruce S Hostager
  • Juan M Zapata
  • Ping Xie
  • Gail A Bishop
  • Genhong Cheng
  • Robert Brink
  • Peng Zhang
  • Jin Jin
  • Hongbo Hu
  • Yichuan Xiao
  • Jeannie Q He
  • Supriya K Saha
  • Laura L Stunz
  • Brian Zarnegar
  • Shao Cong Sun
  • Zuoan Yi
  • Jae Hoon Chang
  • Michael Karin
  • Sandra Gardam
  • Hongliang Li
  • Xi Jiang
  • Ping Hui Tseng
  • Guang Nian Zhao
  • Atsushi Matsuzawa
  • Xuhong Cheng
  • Yan Liu
  • Gagik Oganesyan
  • Dario A A Vignali
  • Xiaoxia Li
  • Weizhou Zhang
  • Sivakumar Vallabhapurapu
  • Pi Xiao Wang
  • Yan Zhang
  • Xueyong Zhu
  • Xiao Jing Zhang
  • Xiao Fei Zhang
  • Lu Gao
  • Almin I Lalani
  • Jun Gong
  • Dandan Lin
  • Elisabeth K Malle
  • Swarupa Panda
  • Zheng Chen
  • Hui Gu
  • Susana Soo Yeon Kim
  • Purnima Gupta
  • Di Feng Fang
  • Youcun Qian
  • Nahum Puebla-Osorio
  • Mikyoung Chang
  • Darren J Perkins
  • George C Brittain
  • Nadin Wimmer
  • Sophia Miliara
  • Irving C Allen
  • Jarod A Zepp
  • Robin Mukhopadhyaya
  • R J Neely
  • Regina Gonzalez-Dosal
  • Baoli Yang
  • Katsuaki Hoshino
  • Yaya Wang
  • Shu Zhu
  • Hideki Sanjo
  • Jian Liang
  • Joanne M Hildebrand
  • Antony Basten
  • Zhenqiang Yao
  • Ingvild B Johnsen
  • Haifa H Jabara
  • Stephane Daffis
  • Abdur Rub
  • Chen Wang
  • Takahito Sanada
  • Haopeng Wang
  • Brian J Zarnegar
  • Natsuko Tanimura
  • Andreas Zirlik
  • Soh Yamazaki
  • Carla V Rothlin
  • Carl F Ware
  • Paul W Dempsey
  • C Tomihara-Newberger
  • Jason R Kang
  • Arash Shahangian
  • Erdyni Tsitsikov
  • Yun Jung Ha
  • Atsushi Ohazama
  • Junhong Guo

Detail Information

Publications80

  1. ncbi TRAF3: a new regulator of type I interferons
    Supriya K Saha
    Department of Microbiology, Immunology and Molecular Genetics, Medical Scientist Training Program, University of California at Los Angeles, Los Angeles, California 90095, USA
    Cell Cycle 5:804-7. 2006
    ..Interestingly, all of the major viral recognition pathways characterized thus far require TRAF3 to initiate type I interferon production...
  2. pmc The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation
    Sharron A N Brown
    Vascular Biology Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Biochem J 371:395-403. 2003
    ..These results indicate that Fn14 is a functional TWEAK receptor that can associate with four distinct TRAF family members and stimulate the NF-kappaB transcription factor signalling pathway...
  3. ncbi Roles of TNF receptor-associated factor 3 in signaling to B lymphocytes by carboxyl-terminal activating regions 1 and 2 of the EBV-encoded oncoprotein latent membrane protein 1
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 173:5546-55. 2004
    ..The present study further investigated how TRAF3 participates in LMP1 signaling...
  4. pmc Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes
    Ping Xie
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Exp Med 199:661-71. 2004
    ..Among these, TRAF3 was the first identified to directly bind both receptors, yet its role remains a mystery...
  5. pmc Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
    Atsushi Matsuzawa
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 321:663-8. 2008
    ..a tumor necrosis factor receptor (TNFR) family member, forms a complex containing adaptor molecules TRAF2 and TRAF3, ubiquitin-conjugating enzyme Ubc13, cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2), IkappaB kinase ..
  6. doi TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
    Sandra Gardam
    Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst NSW 2010, Australia
    Immunity 28:391-401. 2008
    Tumor necrosis factor receptor-associated factors 2 and 3 (TRAF2 and TRAF3) were shown to function in a cooperative and nonredundant manner to suppress nuclear factor-kappaB2 (NF-kappaB2) activation, gene expression, and survival in ..
  7. pmc Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
    Sivakumar Vallabhapurapu
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Cancer Center, University of California, San Diego, California 93093, USA
    Nat Immunol 9:1364-70. 2008
    The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative nuclear factor-kappaB (NF-kappaB) signaling in resting cells by targeting NF-kappaB-inducing kinase (NIK) for ubiquitin-dependent degradation, thus ..
  8. pmc Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK
    Brian J Zarnegar
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E Young Drive East, Los Angeles, California 90095, USA
    Nat Immunol 9:1371-8. 2008
    ..kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or cIAP2...
  9. pmc Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, IA 52242, USA
    Immunity 27:253-67. 2007
    Tumor necrosis factor receptor-associated factor 3 (TRAF3) is an adaptor protein that directly binds to a number of receptors of the tumor necrosis factor receptor (TNF-R) superfamily...
  10. pmc TRAF3 regulates the effector function of regulatory T cells and humoral immune responses
    Jae Hoon Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030
    J Exp Med 211:137-51. 2014
    ..Here we identified TNF receptor-associated factor 3 (TRAF3) as a regulator of Treg cell function...
  11. ncbi Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway
    Jeannie Q He
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 282:3688-94. 2007
    ..Whereas TRAF2, 5, and 6 are activators of the canonical NF-kappaB signaling pathway, TRAF3 is an inhibitor of the noncanonical NF-kappaB pathway...
  12. pmc Rescue of TRAF3-null mice by p100 NF-kappa B deficiency
    Jeannie Q He
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 203:2413-8. 2006
    ..25:280-288). We demonstrate that loss of tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) results in constitutive noncanonical NF-kappaB activity...
  13. pmc Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
    Supriya K Saha
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA
    EMBO J 25:3257-63. 2006
    ..Here, we demonstrate that TRAF3, like Cardif, is required for type I interferon production in response to intracellular double-stranded RNA...
  14. ncbi Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    Hans Hacker
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 439:204-7. 2006
    ..Using MyD88 as a prototypical adaptor, we identified TNF receptor-associated factor 3 (TRAF3) as a new component of TIR signalling complexes that is recruited along with TRAF6...
  15. ncbi Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
    Gagik Oganesyan
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 609 Charles E Young Dr East, Los Angeles, California 90095, USA
    Nature 439:208-11. 2006
    ..Here we demonstrate that cells lacking TRAF3, a member of the TNF receptor-associated factor family, are defective in type I IFN responses activated by several ..
  16. ncbi Act1, a negative regulator in CD40- and BAFF-mediated B cell survival
    Youcun Qian
    Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Immunity 21:575-87. 2004
    ..These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling...
  17. pmc Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
    Ping Hui Tseng
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA
    Nat Immunol 11:70-5. 2010
    ..Here we show that TRAF3, a ubiquitin ligase that interacts with both MyD88 and TRIF, regulated the production of interferon and ..
  18. pmc Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes
    Ping Xie
    Department of Microbiology, The University of Iowa, Iowa City, Iowa, USA
    J Leukoc Biol 90:1149-57. 2011
    The key role of TRAF6 in TLR signaling pathways is well known. More recent evidence has implicated TRAF3 as another TRAF family member important to certain TLR responses of myeloid cells...
  19. ncbi Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses
    Y Xu
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Immunity 5:407-15. 1996
    b>TRAF3 was found as a protein that binds to the cytoplasmic tail of CD40 but is part of a family of proteins with common structure and activity...
  20. pmc 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB
    R H Arch
    Department of Medicine, Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Mol Cell Biol 18:558-65. 1998
    ..While 4-1BB bound TRAF2 and TRAF1, Ox40 interacted with TRAF3 and TRAF2...
  21. pmc TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling
    Ping Xie
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA
    J Immunol 186:143-55. 2011
    ..However, the specific function of TRAF3 in T cells has remained unclear...
  22. pmc Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling
    Shu Zhu
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    J Exp Med 207:2647-62. 2010
    ..In this study, we report that TRAF3 is a receptor proximal negative regulator of IL-17 receptor (IL-17R) signaling...
  23. pmc TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells
    Zuoan Yi
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 210:1079-86. 2013
    ..In this study, we show that TNF receptor associated factor 3 (TRAF3) plays a critical role in the transition between these two distinct signaling pathways and ..
  24. ncbi Involvement of CRAF1, a relative of TRAF, in CD40 signaling
    G Cheng
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Science 267:1494-8. 1995
    ..A yeast two-hybrid screen identified a gene, CRAF1, encoding a protein that interacts directly with the CD40 cytoplasmic tail through a region of similarity to the ..
  25. ncbi Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling
    Bruce S Hostager
    Department of Pediatrics, Interdisciplinary Program in Immunology, University of Iowa, Iowa City 52242, USA
    J Biol Chem 278:45382-90. 2003
    ..We also find that TRAF2 participates in the degradation of TRAF3 associated with CD40 signaling, a role that may limit inhibitory actions of TRAF3...
  26. pmc Control of canonical NF-kappaB activation through the NIK-IKK complex pathway
    Brian Zarnegar
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 105:3503-8. 2008
    ..factor receptor-associated factors (TRAFs) have identified positive roles for TRAF2, TRAF5, and TRAF6, but not TRAF3, in canonical (p50-dependent) NF-kappaB activation...
  27. ncbi The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching
    Haifa Jabara
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunity 17:265-76. 2002
    ..wild-type (WT) and mutant CD40 transgenes that lacked the binding motifs for TRAF6 (CD40deltaTRAF6), TRAF2 and TRAF3 (CD40deltaTRAF2/3), or both (CD40deltaTRAFs) into B cells of CD40(-/-) mice...
  28. pmc Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7
    Stephane Daffis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 5:e1000607. 2009
    ....
  29. pmc SUMOylation is required for optimal TRAF3 signaling capacity
    Sophia Miliara
    Molecular and Cellular Biology Laboratory, University of Crete School of Medicine, Heraklion, Greece Laboratory of Cancer Biology, Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas, Heraklion, Greece
    PLoS ONE 8:e80470. 2013
    ..Here, we report that TRAF3, a TRAF family member with a key role in Toll-like and TNF family receptor signaling and suppressor of ..
  30. pmc MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling
    Jian Liang
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA
    J Exp Med 207:2959-73. 2010
    ..c-Jun N-terminal kinase (JNK) and NF-κB activity by removing ubiquitin moieties from proteins, including TRAF2, TRAF3, and TRAF6. MCPIP1-deficient mice spontaneously developed fatal inflammatory syndrome...
  31. pmc Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production
    Darren J Perkins
    Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, School of Medicine, Baltimore, Maryland, United States of America
    PLoS Pathog 9:e1003479. 2013
    ..This priming effect of TLR2 is mediated by the selective upregulation of the K63 ubiquitin ligase, TRAF3. Thus, we provide a mechanistic explanation for the observed antiviral actions of MyD88-dependent TLR2 and further ..
  32. pmc Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling
    Pi Xiao Wang
    Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Nat Commun 7:10592. 2016
    ..Here we show that tumour necrosis factor receptor-associated factor 3 (TRAF3) is upregulated in mouse and human livers with hepatic steatosis...
  33. pmc Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity
    Zheng Chen
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan
    Am J Physiol Endocrinol Metab 308:E460-9. 2015
    ..b>TRAF3 (TNF receptor-associated factor 3) is a common signaling molecule for these ligands/receptors and negatively ..
  34. doi Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes
    Swarupa Panda
    Laboratory for Molecular Infection Medicine Sweden MIMS, Umea University, 90 187, Umea, Sweden Department of Molecular Biology, Umea University, 90 187, Umea, Sweden Umeå Centre for Microbial Research UCMR, Umea University, 90 187, Umea, Sweden
    Immunity 43:647-59. 2015
    ..that in response to microbial stimuli, MYSM1 accumulated in the cytoplasm where it interacted with and inactivated TRAF3 and TRAF6 complexes to terminate PRR pathways for pro-inflammatory and type I interferon responses...
  35. pmc Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6
    Dandan Lin
    Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China
    Proc Natl Acad Sci U S A 112:11324-9. 2015
    ..USP25 was associated with TRAF3 and TRAF6 after infection by RNA or DNA viruses and protected virus-induced proteasome-dependent or independent ..
  36. doi Neuron-Specific Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke
    Jun Gong
    From the Department of Cardiology, Renmin Hospital J G, S G, X J Z, P Z, G N Z, Y Z, A Z, M X, H L, Animal Experiment Center Animal Biosafety Level III Laboratory J G, S G, X J Z, P Z, G N Z, Y Z, A Z, M X, H L, and College of Life Sciences X F Z, Wuhan University, Wuhan, China Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Z Z L National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Z Z L and Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, TX 77843
    Hypertension 66:604-16. 2015
    ..Here, we report the versatile biological roles of tumor necrosis factor receptor-associated factor 3 (TRAF3) in ischemic stroke...
  37. pmc Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity
    Elisabeth K Malle
    Transplantation Immunology Group, Immunology Division, Cancer Bioinformatics, Cancer Division, B Cell Biology, Immunology Division, and Beta Cell Regeneration, Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia
    J Exp Med 212:1239-54. 2015
    ..These studies reveal that NIK contributes a central mechanism for β cell failure in diet-induced obesity. ..
  38. doi Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy
    Xi Jiang
    From the Department of Cardiology, Renmin Hospital X J, K Q D, D S J, P Z, G N Z, H L, Cardiovascular Research Institute X J, K Q D, D S J, P Z, G N Z, X Z, H L, and College of Life Sciences X F Z, G N Z, Wuhan University, Wuhan, PR China Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Second Affiliated Hospital of Chongqing Medical University, Chongqing, PR China Y L and Department of Cardiology, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China L G
    Hypertension 66:356-67. 2015
    ..Here, we identified tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein in tumor necrosis factor-related signaling cascades, as a key regulator of cardiac ..
  39. pmc Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages
    Jin Jin
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nat Commun 6:5930. 2015
    ..Interestingly, TRAF2 controls the fate of c-Rel and IRF5 via a proteasome-dependent mechanism that also requires TRAF3 and the E3 ubiquitin ligase cIAP...
  40. doi Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response
    Purnima Gupta
    2Department of Biochemistry, University of Calcutta, 35, Ballygunge Circular Rd, Kolkata 700019, India
    FASEB J 28:1756-68. 2014
    ..donovani and L. donovani + LPS costimulated macrophages. TRAF3, which was ubiquitinated (2...
  41. pmc The miR-322-TRAF3 circuit mediates the pro-apoptotic effect of high glucose on neural stem cells
    Hui Gu
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang 110004, China, Department of Biochemistry and Molecular Biology and Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201 Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang 110004, China, Department of Biochemistry and Molecular Biology and Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland 21201
    Toxicol Sci 144:186-96. 2015
    ..This study investigates the role of miR-322 and its putative target gene, TNF receptor-associated factor 3 (TRAF3), in high glucose-induced apoptosis...
  42. pmc Myeloid cell TRAF3 regulates immune responses and inhibits inflammation and tumor development in mice
    Almin I Lalani
    Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854 Graduate Program in Cellular and Molecular Pharmacology, Rutgers University, Piscataway, NJ 08854
    J Immunol 194:334-48. 2015
    ..In vitro studies showed that TRAF3 is required for TLR-induced type I IFN production, but the in vivo function of TRAF3 in myeloid cells remains ..
  43. doi NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation
    Di Feng Fang
    1 State Key Laboratory of Proteomics, National Center of Biomedical Analysis, Institute of Basic Medical Sciences, Beijing 100850, China 2
    Nat Commun 5:4513. 2014
    ..NEDD4 constitutively interacts with CD40 and mediates K63-linked ubiquitination of TNFR-associated factor3 (TRAF3). The ubiquitination of TRAF3 by NEDD4 is critical for CD40-mediated AKT activation...
  44. ncbi TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells
    Andreas Zirlik
    Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 27:1101-7. 2007
    ..This study investigated the involvement of tumor necrosis factor receptor-associated factors (TRAFs) in CD40 signaling in endothelial cells (ECs) and their expression in atheromata and cells involved in atherogenesis...
  45. pmc TRAF3 regulates homeostasis of CD8+ central memory T cells
    Zuoan Yi
    Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 9:e102120. 2014
    Our laboratory reported previously that TNF receptor associated factor 3 (TRAF3) is a positive regulator of TCR signaling and T cell function...
  46. doi DOK3 is required for IFN-β production by enabling TRAF3/TBK1 complex formation and IRF3 activation
    Susana Soo Yeon Kim
    Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228 Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668 and
    J Immunol 193:840-8. 2014
    ..DOK3 was also shown to bind TRAF3, and the binding of TRAF3 and TBK1 to DOK3 required the tyrosine-rich C-terminal domain of DOK3...
  47. pmc Cutting edge: TNF receptor-associated factor 4 restricts IL-17-mediated pathology and signaling processes
    Jarod A Zepp
    Department of Immunology, Cleveland Clinic, Cleveland, OH 44195, USA
    J Immunol 189:33-7. 2012
    ..Taken together, the results of this study reveal the necessity of a unique role of TRAF4 in restricting the effects of IL-17 signaling and Th17-mediated disease...
  48. pmc NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling
    Irving C Allen
    Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 36:742-54. 2012
    ..The noncanonical NF-κB pathway was regulated upon degradation of TRAF3 and activation of NIK...
  49. pmc HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6
    Regina Gonzalez-Dosal
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS Pathog 7:e1002250. 2011
    ..particular, by performing mutational studies we show that S-glutathionylation of a conserved cysteine residue of TRAF3 and TRAF6 is important for ROS-dependent activation of innate immune pathways...
  50. pmc Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5
    Peng Zhang
    State Key Laboratory of Biomacromolecules, CAS Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China
    Sci Signal 5:ra81. 2012
    ..of RIG-I (retinoic acid-inducible gene I), a component of a pattern recognition receptor that detects viruses, TRAF3 binds to the adaptor protein Cardif [caspase activation and recruitment domain (CARD) adaptor-inducing interferon-..
  51. pmc A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling
    Joanne M Hildebrand
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 207:2569-79. 2010
    ..This mutation encodes a His159Tyr substitution in the cytoplasmic tail of BAFF-R adjacent to the TRAF3 binding motif...
  52. doi Lymphotoxin-beta receptor signalling regulates cytokine expression via TRIM30α in a TRAF3-dependent manner
    Nadin Wimmer
    Institute of Immunology, University of Regensburg, 93053 Regensburg, Germany
    Mol Immunol 54:40-7. 2013
    ..Furthermore, the LTβR-induced TRIM30α expression seems to be TRAF3 dependent...
  53. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
    ..the non-canonical NF-κB pathway involves degradation of an inhibitory protein, TNF receptor-associated factor 3 (TRAF3), but how this signalling event is controlled is still unknown...
  54. pmc Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
    Yichuan Xiao
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 19:595-602. 2013
    ..regulates Toll-like receptor (TLR) pathway signaling by promoting degradation of TNF receptor-associated factor 3 (Traf3), a potent inhibitor of mitogen-activated protein kinase (MAPK) activation and gene induction...
  55. doi The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
    Chen Wang
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China
    Nat Immunol 10:744-52. 2009
    ..Our data suggest that Nrdp1 functions as both an adaptor protein and an E3 unbiquitin ligase to regulate TLR responses in different ways...
  56. pmc NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
    Zhenqiang Yao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Clin Invest 119:3024-34. 2009
    ..TNF, but not RANKL, increased OCP expression of TNF receptor-associated factor 3 (TRAF3), an adapter protein that regulates NF-kappaB p100 levels in B cells...
  57. ncbi TAM receptors are pleiotropic inhibitors of the innate immune response
    Carla V Rothlin
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cell 131:1124-36. 2007
    ....
  58. ncbi A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein
    X Wang
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
    Dev Biol 177:274-90. 1996
    ..Thus, we have named the gene encoding the 7. 5-kb transcript TRAFamn. TRAFamn is identical to a recently reported protein (CD40bp, CAP-1, CRAF1, LAP1) that can bind the cytoplasmic ..
  59. ncbi Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development
    R Masson
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Strasbourg, France
    Mech Dev 71:187-91. 1998
    ..TRAF4 is preferentially expressed by post-mitotic undifferentiated neurons. Interestingly, TRAF4 remains expressed in the adult hippocampus and olfactory bulb, known to contain multipotential cells responsible for neoneurogenesis...
  60. ncbi The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives
    C Tomihara-Newberger
    Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, New York, 10021, USA
    Dev Biol 204:34-54. 1998
    ....
  61. ncbi Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies
    A P Kuan
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunogenetics 49:79-85. 1999
    ..Future studies will determine whether the genetic factors identified in this study are also involved in susceptibility to rheumatic fever...
  62. pmc Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    H Hsu
    Department of Cell Biology, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Proc Natl Acad Sci U S A 96:3540-5. 1999
    ..These data indicate that OPGL-induced osteoclastogenesis is directly mediated through RANK on osteoclast precursor cells...
  63. ncbi TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death
    M T Eby
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    J Biol Chem 275:15336-42. 2000
    ..Although it lacks a death domain, TAJ is capable of inducing apoptosis by a caspase-independent mechanism. Based on its unique expression profile and signaling properties, TAJ may play an essential role in embryonic development...
  64. ncbi The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain
    S Kalantry
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Sciences of Cornell University, New York, New York, USA
    Nat Genet 27:412-6. 2001
    ..into these functional regions, we have cloned and functionally identified the gene disrupted in the amnionless (amn) mouse, which has a recessive, embryonic lethal mutation that interferes specifically with the formation and/or ..
  65. ncbi An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation
    Abi S Witherden
    Department of Neurogenetics, Imperial College, W2 1PG, London, UK
    Gene 283:71-82. 2002
    ..We show a summary of 95 markers and 91 genomic clones that has enabled us to identify 18 transcripts including new genes and candidates for Loa which will help in future studies of gene context and regulation...
  66. ncbi Expression of TNF-receptor-associated factor genes in murine tooth development
    Atsushi Ohazama
    Department of Craniofacial Development, GKT Dental Institute, King s College London, Guy s Hospital, Floor 28, Guy s Tower, London Bridge, London SE1 9RT, UK
    Gene Expr Patterns 3:127-9. 2003
    ..We carried out comparative in situ hybridization analysis of five Traf genes Traf1, Traf2, Traf3, Traf4 and Traf6 during murine odontogenesis from the formation of the epithelial thickening to the early bell ..
  67. ncbi Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase
    Yun Jung Ha
    Division of Molecular Life Sciences and Center for Cell Signaling Research, College of Natural Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, Korea
    J Immunol 172:231-9. 2004
    ..Molecular association studies further revealed that the TRAF3 association with p40(phox), a cytosolic subunit of NADPH oxidase and p85 (a subunit of PI3-K), may possibly be ..
  68. doi Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
    Sandra Gardam
    Immunology Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
    Blood 117:4041-51. 2011
    ..signals are controlled by the homologous RING finger proteins cIAP1 and cIAP2, in collaboration with TRAF2 and TRAF3. There is also mounting evidence that all 4 of these signaling molecules can act as tumor suppressors in human B-..
  69. doi Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling
    Natsuko Tanimura
    Department of Microbiology and Immunology, Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 368:94-9. 2008
    ..The internalized signaling complex consisting of TLR4 and TRAM colocalizes with TRAF3, a signaling molecule downstream of TRIF, in endosome/lysosome...
  70. pmc FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway
    Takahito Sanada
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 283:33858-64. 2008
    ..We also found that FLN29 could interact with TRIF, IPS-1, TRAF3, and TRAF6...
  71. pmc Lymphocyte-specific TRAF3 transgenic mice have enhanced humoral responses and develop plasmacytosis, autoimmunity, inflammation, and cancer
    Juan M Zapata
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Blood 113:4595-603. 2009
    Tumor necrosis factor (TNF) receptor-associated factor 3 (TRAF3) regulates both innate and adaptive immunity by modulating signaling by Toll-like receptors (TLR) and TNF receptors...
  72. doi Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function
    Abdur Rub
    National Centre for Cell Science, Ganeshkhind, Pune 411007, India
    Nat Immunol 10:273-80. 2009
    ..membrane cholesterol inhibited the assembly of an IL-12-inducing CD40 signalosome containing the adaptors TRAF2, TRAF3 and TRAF5 and the kinase Lyn and promoted the assembly of an IL-10-inducing CD40 signalosome containing the ..
  73. pmc TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40
    Haifa H Jabara
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 21:477-88. 2009
    ..To define the individual roles of TRAF2 and TRAF3 in CD40 activation of B cells, we introduced mutant CD40 transgenes that selectively lack the ability to bind ..
  74. pmc The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling
    Ingvild B Johnsen
    Department of Laboratory Medicine, Children s and Women s Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim N 7006, Norway
    J Biol Chem 284:19122-31. 2009
    ..In addition, we found that c-Src interacted with components of the RIG-I pathway: RIG-I, MAVS, and TRAF3 (tumor necrosis factor receptor-associated factor-3)...
  75. doi Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells
    Katsuaki Hoshino
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Graduate School of Nanobioscience, Yokohama City University, Yokohama, Japan
    J Immunol 184:3341-5. 2010
    ..Our results show that IKKalpha is a unique molecule involved in TLR7/9-MyD88-dependent type I IFN production through DC subset-specific mechanisms...
  76. pmc Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor
    Hideki Sanjo
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Biol Chem 285:17148-55. 2010
    ..We found that insertion of a charge-repulsion mutation in the receptor-binding crevice of TRAF3 ablated binding of both LTbetaR and NIK suggesting a common recognition site...
  77. pmc HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex
    Bruce S Hostager
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11380. 2010
    ....
  78. pmc The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK
    R J Neely
    Department of Animal Biology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Oncogene 30:87-96. 2011
    ..Notably, NIK stabilization was not accompanied by TRAF3 degradation demonstrating that RP3 disrupts normal basal NIK regulation...

Research Grants1

  1. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
    ..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..