Tpsg1

Summary

Gene Symbol: Tpsg1
Description: tryptase gamma 1
Alias: Prss31, Tmt, tryptase gamma, transmembrane tryptase
Species: mouse

Top Publications

  1. pmc Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis
    Philip M Hansbro
    From the Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales 2308, Australia
    J Biol Chem 289:18214-27. 2014
  2. ncbi Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension
    G W Wong
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 274:30784-93. 1999
  3. ncbi Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families
    G H Caughey
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco 94143, USA
    J Immunol 164:6566-75. 2000
  4. ncbi Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns
    Guang W Wong
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:2438-52. 2004
  5. ncbi Murine implantation serine proteinases 1 and 2: structure, function and evolution
    Lin Tang
    Department of Oncology, University of Calgary, Calgary, Canada
    Gene 364:30-6. 2005
  6. doi The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium
    Alex Gregorieff
    Hubrecht Institute, Utrecht, The Netherlands
    Gastroenterology 137:1333-45.e1-3. 2009

Scientific Experts

  • G H Caughey
  • Philip M Hansbro
  • Richard L Stevens
  • Alex Gregorieff
  • Lin Tang
  • Guang W Wong
  • Michael Fricker
  • Sahar Hamadi
  • Saijun Zhou
  • Steven A Krilis
  • Paul S Foster
  • Sandra M Frei
  • Dominick Zheng
  • Shaan L Gellatly
  • Andrew G Jarnicki
  • Matthew J Hamilton
  • G William Wong
  • Pekka Kujala
  • Daniel E Stange
  • Peter J Peters
  • Maaike van den Born
  • Jeroen Korving
  • Harry Begthel
  • Hans Clevers
  • G W Wong
  • Derrick E Rancourt
  • Shinsuke Yasuda
  • Lixin Li
  • Nasa Morokawa
  • L Li
  • Y Li
  • R L Stevens
  • D S Friend
  • A Sali
  • C Huang
  • S A Krilis
  • Y Tang
  • E Feyfant

Detail Information

Publications6

  1. pmc Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis
    Philip M Hansbro
    From the Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales 2308, Australia
    J Biol Chem 289:18214-27. 2014
    Protease serine member S31 (Prss31)/transmembrane tryptase/tryptase-γ is a mast cell (MC)-restricted protease of unknown function that is retained on the outer leaflet of the plasma membrane when MCs are activated...
  2. ncbi Identification of a new member of the tryptase family of mouse and human mast cell proteases which possesses a novel COOH-terminal hydrophobic extension
    G W Wong
    Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 274:30784-93. 1999
    ..Comparative structural studies indicated that the putative transmembrane tryptase (TMT) possesses a unique substrate-binding cleft...
  3. ncbi Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families
    G H Caughey
    Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco 94143, USA
    J Immunol 164:6566-75. 2000
    ..In summary, this work describes gamma-tryptases, which are novel members of chromosome 16p tryptase/prostasin gene families. Their unique features suggest possibly novel functions...
  4. ncbi Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns
    Guang W Wong
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:2438-52. 2004
    ..This information provides a useful framework for the functional analysis of each protease using gene targeting and other molecular approaches...
  5. ncbi Murine implantation serine proteinases 1 and 2: structure, function and evolution
    Lin Tang
    Department of Oncology, University of Calgary, Calgary, Canada
    Gene 364:30-6. 2005
    ..Inhibition of ISP proteolytic function has implicated this enzyme in the processes of embryo hatching and implantation...
  6. doi The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium
    Alex Gregorieff
    Hubrecht Institute, Utrecht, The Netherlands
    Gastroenterology 137:1333-45.e1-3. 2009
    ..In this study, we investigated the role of the Wnt-responsive, Ets-domain transcription factor Spdef in the differentiation of goblet and Paneth cells...