Genomes and Genes
Gene Symbol: Tpm1
Description: tropomyosin 1, alpha
Alias: AA986836, AI854628, TM2, Tm3, Tmpa, Tpm-1, alpha-TM, tropomyosin alpha-1 chain, alpha-tropomyosin, tropomyosin-1
- KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylationSiang Yun Ang
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA 94158, USA Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94158, USA
Development 143:810-21. 2016..Our findings indicate that KMT2D is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation. ..
- The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin positionJi Young Mun
Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Mol Cell Cardiol 91:141-7. 2016..We conclude that the L348P mutation causes a gain of function by enhancing tropomyosin displacement on the thin filament in a phosphorylation-independent way. ..
- Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markersGiuseppina Mastrototaro
Humanitas Clinical and Research Center, Via Manzoni 113, 20089 Rozzano, Milan, Italy University of Milano Bicocca, Milan, Italy
Cardiovasc Res 107:216-25. 2015..However, the role of nebulette in vivo has remained elusive. To provide insights into the function of nebulette in vivo, we generated and studied nebulette-deficient (nebl(-) (/-)) mice...
- Structure of the F-actin-tropomyosin complexJulian von der Ecken
Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany
Nature 519:114-7. 2015..Our results allow us to understand the role of individual mutations in the genesis of actin- and tropomyosin-related diseases and will serve as a strong foundation for the targeted development of drugs. ..
- A systematic nomenclature for mammalian tropomyosin isoformsMichael A Geeves
School of Biosciences, University of Kent, Canterbury, CT2 7NJ, UK
J Muscle Res Cell Motil 36:147-53. 2015..The National Center for Biotechnology Information (NCBI) website has been amended to include the nomenclature for the human, mouse and rat genes. ..
- Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryoCaroline R McKeown
Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California
Dev Dyn 243:800-17. 2014We explored a function for tropomyosin (TM) in mammalian myofibril assembly and cardiac development by analyzing a deletion in the mouse TPM1 gene targeting αTM1, the major striated muscle TM isoform.
- Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1M Schleef
Developmental Biology Unit, University of Bielefeld, Federal Republic of Germany
Genomics 17:519-21. 1993..5-kb of Tpm-1. The same restriction patterns were observed, proving the identity of the mapped and the cloned gene. The identity was supported by sequencing the 3' end of the gene...
- Decreasing tropomyosin phosphorylation rescues tropomyosin-induced familial hypertrophic cardiomyopathyEmily M Schulz
From the Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
J Biol Chem 288:28925-35. 2013..This is the first study to demonstrate that decreasing phosphorylation of tropomyosin can rescue a hypertrophic cardiomyopathic phenotype. ..
- Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substratesCarrie E Rubel
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7126, USA
Cell Biochem Biophys 67:127-38. 2013....
- N terminus is essential for tropomyosin functions: N-terminal modification disrupts stress fiber organization and abolishes anti-oncogenic effects of tropomyosin-1Shantaram Bharadwaj
Departments of General Surgery and Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Biol Chem 279:14039-48. 2004..Our studies provide in vivo functional evidence that the N terminus is a critical determinant of TM1 functions, which in turn determines the organization of stress fibers...
- Tropomyosin dephosphorylation results in compensated cardiac hypertrophyEmily M Schulz
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Biol Chem 287:44478-89. 2012..Collectively, these results suggest that modification of the Tm phosphorylation status in the heart, depending upon the cardiac state/condition, may modulate the development of cardiac hypertrophy...
- ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domainN Nakagawa
Department of Structural Molecular Biology, Osaka University, Japan
Biochem Biophys Res Commun 272:505-12. 2000....
- Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasisPaul Delgado-Olguín
Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
Nat Genet 44:343-7. 2012..Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses...
- RBM4 promotes pancreas cell differentiation and insulin expressionJung Chun Lin
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Mol Cell Biol 33:319-27. 2013..These results suggest that RBM4 may have role in promoting pancreas cell differentiation and endocrine function, essentially via alternative splicing regulation...
- Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxationBenjamin R Nixon
Department of Physiology and Cell Biology and The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States
Arch Biochem Biophys 535:30-8. 2013..This supports a role for Tm as a key protein in the regulation of muscle relaxation dynamics...
- Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137LSumeyye Yar
Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 288:16235-46. 2013..Thus, our results provide insight into the link between flexibility of TM and its function in ejecting hearts...
- Evaluation of candidate markers for the peritubular myoid cell lineage in the developing mouse testisAngela Jeanes
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
Reproduction 130:509-16. 2005..Collagen type-I, inhibinbetaA, caldesmon 1 and tropomyosin 1 were found to be expressed by early-stage PM cells...
- cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveformRashid Nassar
Department of Pediatrics, Duke University, Durham, NC, USA
Am J Physiol Heart Circ Physiol 288:H1147-56. 2005....
- MusTRD can regulate postnatal fiber-specific expressionLaura L Issa
Muscle Development Unit, Children s Medical Research Institute, Wentworthville, NSW 2145, Australia
Dev Biol 293:104-15. 2006..These data are consistent with our initial predictions for hMusTRD1alpha1 and suggest that slow fiber genes contain a specific common regulatory element that can be targeted by MusTRD proteins...
- Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamicsRobert D Gaffin
Cardiovascular Research Institute and Department of Systems Biology and Translational Medicine, College of Medicine, Texas A and M University System Health Science Center, TX 77843 1114, USA
Am J Physiol Heart Circ Physiol 291:H552-63. 2006....
- Tropomyosin isoforms localize to distinct microfilament populations in osteoclastsBrooke K McMichael
Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
Bone 39:694-705. 2006..This compartmentalization of tropomyosins to specific actin structures within osteoclasts is likely to play a critical role in determining the dynamic properties of the actin cytoskeleton and thus osteoclast activity...
- p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activitySusan Vahebi
Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Ave, Chicago, IL 60612 7342, USA
Circ Res 100:408-15. 2007..These data are the first to indicate that chronic activation of p38alpha MAPK directly depresses sarcomeric function in association with decreased phosphorylation of alpha-tropomyosin...
- Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesisGanapathy Jagatheesan
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
Am J Physiol Heart Circ Physiol 293:H949-58. 2007..These results demonstrate that alterations in calcium response by modification of contractile proteins can prevent the pathological and physiological effects of this disease...
- Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivitySudarsan Rajan
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, Cincinnati, OH 45267 0524, USA
Circ Res 101:205-14. 2007..As such, this is the first mouse model in which a mutation in a sarcomeric thin filament protein, specifically TM, leads to DCM...
- Divergent regulation of the sarcomere and the cytoskeletonGalina Schevzov
Oncology Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales 2145, Australia
J Biol Chem 283:275-83. 2008..Comprehensive analyses of tissues from transgenic and knock-out mouse lines that overexpress the cytoskeletal Tms, Tm3 and Tm5NM1, and a comparison with sarcomeric Tms provide evidence for this...
- Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failureJian Fu Chen
Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
Proc Natl Acad Sci U S A 105:2111-6. 2008..Together, our studies demonstrate essential roles for Dicer in cardiac contraction and indicate that miRNAs play critical roles in normal cardiac function and under pathological conditions...
- Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in miceXiaoli Liu
Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Circulation 119:261-8. 2009..Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation...
- Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and directionCuc T T Bach
Oncology Research Unit, The Children s Hospital at Westmead, Westmead, New South Wales 2145, Australia
Mol Cell Biol 29:1506-14. 2009..Thus, we propose that Tm5NM1 can regulate the feedback loop between focal adhesion disassembly and focal complex formation at the leading edge that is required for productive and directed cell movement...
- Optimising experimental design for high-throughput phenotyping in mice: a case studyNatasha A Karp
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
Mamm Genome 21:467-76. 2010..Consequently, in confirmatory studies, a power analysis along with the 3Rs can provide justification to increase the number of mice used...
- Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failureNabeel J Al Moamen
Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Mol Cell Cardiol 50:137-46. 2011..Thus, in the TM180 cardiomyopathy model, loss of AE3 had no apparent anti-hypertrophic effect and led to more rapid decompensation and heart failure...
- Expression of tropomyosin-κ induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylationChehade N Karam
Department of Physiology and Biophysics, Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Ave M C 901, Chicago, IL 60612 7342, USA
J Muscle Res Cell Motil 31:315-22. 2011Tropomyosin-kappa (TPM1-κ) is a newly discovered tropomyosin (TM) isoform that is exclusively expressed in the human heart and generated by an alternative splicing of the α-TM gene...
- Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje networkShan Shan Zhang
Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:13576-81. 2011..Irx3 directly represses Cx43 transcription and indirectly activates Cx40 transcription. Our results reveal a critical role for Irx3 in the precise regulation of intercellular gap junction coupling and impulse propagation in the heart...
- Tropomyosin in preimplantation mouse development: identification, expression, and organization during cell division and polarizationL Clayton
Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, United Kingdom
Exp Cell Res 238:450-64. 1998..We conclude that the early mouse conceptus contains a unique and specific set of tropomyosins which respond to polarizing signals...
- Coordinate induction of fibronectin, fibronectin receptor, tropomyosin, and actin genes in serum-stimulated fibroblastsR P Ryseck
European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
Exp Cell Res 180:537-45. 1989....
- Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2K Takenaga
Division of Chemotherapy and Biochemistry, Chiba Cancer Center Research Institute, Japan
Mol Cell Biol 8:5561-5. 1988We isolated and characterized a cDNA clone encoding tropomyosin isoform 2 (TM2) from a mouse fibroblast cDNA library...
- Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouseM Schleef
University of Bielefeld, Developmental Biology Unit, Germany
Neuromuscul Disord 4:205-17. 1994..A cDNA derived from the 1100 nucleotide parvalbumin transcript was cloned and the sequence for the as yet unknown 3' extended trailer, generated by alternative polyadenylation, was determined...
- Chromosome mapping of nine tropomyosin-related sequences in miceM Gariboldi
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy
Mamm Genome 6:273-7. 1995....
- Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryosM Muthuchamy
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
Mol Cell Biol 13:3311-23. 1993..Our results show for the first time that the alpha- and beta-TM striated muscle transcripts are present in the earliest functional stages of the heart, and these TM isoforms are identical to those present throughout cardiac development...
- Assignment of the human skeletal muscle alpha-tropomyosin gene (TPM1) to band 15q22 by fluorescence in situ hybridizationH Eyre
Department of Cytogenetics and Molecular Genetics, Women s and Children s Hospital, North Adelaide, Australia
Cytogenet Cell Genet 69:15-7. 1995A sequence-tagged site (STS) was developed for the human skeletal muscle alpha-tropomyosin gene (TPM1) and used to isolate a genomic clone, lambda TPM1.1, containing part of the TPM1 gene...
- Molecular diversity of myofibrillar proteins: gene regulation and functional significanceS Schiaffino
Department of Biomedical Sciences, University of Padova, Padua, Italy
Physiol Rev 76:371-423. 1996..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
- Anti-oncogenic effects of tropomyosin: isoform specificity and importance of protein coding sequencesR H Braverman
Laboratory of Cellular Oncology, NCI, Bethesda, Maryland 20892, USA
Oncogene 13:537-45. 1996..specificity in cellular transformation, cDNAs that consist of coding sequences of TM1 (product of beta gene) and TM2 (product of alpha gene), but lacking untranslated regions (UTRs), have been expressed separately in DT (v-Ki-ras ..
- Contractile protein mutations and heart diseaseK L Vikstrom
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309 0347, USA
Curr Opin Cell Biol 8:97-105. 1996Mutations in several muscle structural proteins (the myosin heavy chain, alpha tropomyosin, cardiac troponin T and myosin binding protein C) result in a genetically dominant heart disease, hypertrophic cardiomyopathy...
- Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectivelyR Klocke
Developmental Biology Unit W7, University of Bielefeld, Germany
Genomics 41:290-2. 1997..Potential relations of both loci to disease genes are discussed...
- Targeted ablation of the murine alpha-tropomyosin geneE M Blanchard
Howard Hughes Medical Institute, Boston, Mass, USA
Circ Res 81:1005-10. 1997..These findings imply that in heterozygotes there is a regulatory mechanism that maintains the level of myofibrillar tropomyosin despite the reduction in alpha-tropomyosin mRNA...
- Molecular and physiological effects of alpha-tropomyosin ablation in the mouseP Rethinasamy
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinatti Medical Center, OH 45267 0524, USA
Circ Res 82:116-23. 1998..The present study suggests that translational regulation plays a major role in the control of TM expression...
- Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9K Yamazaki
Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
Genomics 46:528-9. 1997
- Specific features of neuronal size and shape are regulated by tropomyosin isoformsGalina Schevzov
Oncology Research Unit, The Children s Hospital at Westmead, Westmead NSW 2145, Australia
Mol Biol Cell 16:3425-37. 2005..expression on neuronal morphogenesis, embryonic cortical neurons from transgenic mice expressing the isoforms Tm3 and Tm5NM1, under the control of the beta-actin promoter, were cultured in vitro...
- Tissue-specific expression and mapping of the Cox7ah gene in mouseS A Jaradat
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Genomics 49:363-70. 1998..1. As a result, all three COX heart isoform genes in mouse group to chromosome 7. Interestingly, mapping of the mouse Cox7al to chromosome 9 suggests a new syntenic region between the mouse and the human genomes...
- p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardiumL K Kochilas
Division of Pediatric Cardiology, Children s Hospital of Philadelphia, Pennsylvania, USA
Pediatr Res 45:635-42. 1999..This result and further structural analysis suggests that the myocardial defect of Splotch embryos is associated with precocious cardiomyocyte differentiation...
- Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunctionM Muthuchamy
Department of Molecular Genetics, Division of Cardiology, University of Cincinnati College of Medicine, OH 45267 0524, USA
Circ Res 85:47-56. 1999..Thus, the FHC alpha-TM transgenic mouse can serve as a model system for the examination of pathological and physiological alterations imparted through aberrant TM isoforms...
- A mutation in alpha-tropomyosin(slow) affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathyM A Corbett
Muscle Development Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, New South Wales 2145, Australia
Hum Mol Genet 10:317-28. 2001..We suggest that the clinical phenotype is precipitated by a failure of the hypertrophy to persist and therefore compensate for muscle weakness...
- PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosinJ R Patel
Department of Physiology, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
Am J Physiol Heart Circ Physiol 280:H2732-9. 2001..These results show that PKA-mediated phosphorylation of myofibrillar proteins significantly alters the static and dynamic mechanical properties of myocardium, and these effects occur regardless of the type of Tm expressed...
- Impaired motor coordination in mice that lack puncW Yang
Department of Human Genetics, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112, USA
Mol Cell Biol 21:6031-43. 2001..Compared with control littermates, however, homozygous mutants had significantly reduced retention times on the Rotarod, suggesting a role for Bergmann glia-expressed Punc in the cerebellar control of motor coordination...
- Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of miceHenning Wittenburg
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Physiol Genomics 8:67-77. 2002..According to standard nomenclature, the gallstone QTL on chromosome 9 is named Lith5...
- Altered signaling surrounding the C-lobe of cardiac troponin C in myofilaments containing an alpha-tropomyosin mutation linked to familial hypertrophic cardiomyopathyEileen M Burkart
Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S Wolcott Avenue, MC 901, Room E 202 MSB, Chicago, IL 606127342, USA
J Mol Cell Cardiol 35:1285-93. 2003..Although levels of phosphorylation at protein kinase C-dependent sites were the same in TG and NTG myofilaments, our data indicate that the effects of phosphorylation were more depressive in TG hearts...
- A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutationRethinasamy Prabhakar
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
Mol Cell Biochem 251:33-42. 2003..This study demonstrates that mutations within tropomyosin can be severely disruptive of sarcomeric function, triggering a hypertrophic response coupled with a cascade of alterations in gene expression...
- The PTB interacting protein raver1 regulates alpha-tropomyosin alternative splicingNatalia Gromak
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
EMBO J 22:6356-64. 2003..This suggests a novel mechanism for PTB-mediated splicing repression involving recruitment of raver1 as a potent splicing co-repressor...
- Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractilityRobert D Gaffin
Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
J Physiol 556:531-43. 2004..Our results provide the first evidence that charge changes at the carboxy-terminal of alpha-TM alter the functional characteristics of the heart at both the whole organ and myofilament levels...
- Charged residue alterations in the inner-core domain and carboxy-terminus of alpha-tropomyosin differentially affect mouse cardiac muscle contractilityRobert D Gaffin
Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, 336 Reynolds Medical Building, College Station, TX 77843 1114, USA
J Physiol 561:777-91. 2004..These data demonstrate that changing charged residues at either the inner-core domain or the carboxyl end of TM alters sarcomeric performance differently, suggesting that the function of TM is compartmentalized along its length...
- Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of JunP M Chevray
Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Proc Natl Acad Sci U S A 89:5789-93. 1992..Our results illustrate the range of protein interaction cloning for discovering proteins that bind to a given target polypeptide...
- ANALYSIS OF FUNCTIONAL ROLE OF TROPOMYOSIN IN HEARTMariappan Muthuchamy; Fiscal Year: 2002..Cardiovascular studies using transgenic mouse model will provide explicit information on the heart function during both normal and diseased states. ..
- Mechanobiology of CardiomyocytesMariappan Muthuchamy; Fiscal Year: 2006..This will provide novel insight into transduction mechanisms of myocytes. ..
- Molecular Mechanisms of Lymphatic Muscle ContractionMariappan Muthuchamy; Fiscal Year: 2009..The contractile mechanisms of lymphatics have not been known before and will significantly advance our understanding of the basis for the lymphatic vessel function. ..